V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

VENTX Gene

protein-coding GIFtS: 49

GC10P134941

VENT homeobox homolog (Xenopus laevis)
(Previous name: VENT-like homeobox 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VENTX2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HPX42B ^¹, ², ³
MGC119910 ^²
MGC119911 ^²
NA88A ^²
OTTHUMP00000020791 ^²
VENTX2 ^², ³

Descriptions
VENT homeobox ^²
VENT homeobox homolog ^³
VENT homeobox homolog (Xenopus laevis) ^²
VENT-like homeobox 2 ^¹, ²
VENT-like homeobox protein 2 ^³
hemopoietic progenitor homeobox protein VENTX2 ^²

External Ids
HGNC: 13639¹
Entrez Gene: 27287²
UniProtKB: O95231³
Ensembl: ENSG00000151650⁷

Search outside databases for aliases for VENTX gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VENTX:

This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may

function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic

stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located

on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq]

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231

Function: May be involved in ventralization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VENTX gene

Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3

VENTX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P134941: (about GC identifiers)

Start:	134,901,398 bp from pter
End:	134,905,423 bp from pter
Size:	4,026 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_017795.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231 (See protein sequence)

Recommended Name: Homeobox protein VENTX

Size: 258 amino acids; 27552 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q32MZ3

REFSEQ proteins: NP_055283.1

ENSEMBL proteins:

ENSP00000357556

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VENTX)
	Human Recombinant Proteins from Abnova (VENTX)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for VENTX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (VENTX), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VENTX)
	Novus Biologicals Antibodies for VENTX

Assays for VENTX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95231

ProtoNet protein and cluster: O95231

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231

Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VENTX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VENTX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014468

Applied Biosystems Silencer® siRNAs for VENTX

Sigma-Aldrich siRNA for VENTX

Sigma-Aldrich shRNA for VENTX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VENTX
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014468
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014468
untagged cDNA clone in CMV expression vector: NM_014468

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014468

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231

Function: May be involved in ventralization

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VENTX

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VENTX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VENTX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014468

Sigma-Aldrich siRNA for VENTX

Sigma-Aldrich shRNA for VENTX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014468

REFSEQ mRNAs for VENTX gene:

NM_014468.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014468

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014468
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014468
                                 untagged cDNA clone in CMV expression vector: NM_014468

Additional cDNA sequence:

AF068006.1 BC108915.1 BC108916.1

1 DOTS entry:

DT.95220313

9 AceView cDNA sequences:

CA390754 AA973729 NM_014468 BX089390 BM676533 AF068006 W37703 AA872096

W37326

highest scoring ESTs for VENTX:

AF068006 AA872096 AA973729 BM676533 BX089390 W37326 W37703 CA390754 CN305392 NM_014468

Unigene Cluster for VENTX:

VENT homeobox homolog (Xenopus laevis)

Hs.125231 [show with all ESTs]

Unigene Representative Sequence: AF068006

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000325980

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VENTX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VENTX

¹ / ² / ³

3 probe-sets matching VENTX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37790_at²^{, 3}	U95-A	2	1.00	0.88	1.00	1.00	AF068006	1.00	1.00	1.00	1
207376_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014468	0.60	1.00	0.82	1
207376_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.125231
Expression variation in blood from EXPOLDB for VENTX
UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231
Tissue specificity: Expressed in bone marrow of patients recovering from chemotherapy. Also
expressed in an erythroleukemia cell line

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VENTX gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VENTX¹	--	VENT homeobox homolog (Xenopus laevis)	69.84(n) 57.14(a)	491700 XM_548821.2 XP_548821.2
chimpanzee (Pan troglodytes)	VENTX¹	--	VENT homeobox homolog (Xenopus laevis)	98.06(n) 96.9(a)	466266 XM_521666.2 XP_521666.1
chicken (Gallus gallus)	VENTX¹	--	VENT homeobox homolog (Xenopus laevis)	54.4(n) 46.11(a)	430089 XM_427647.2 XP_427647.2
zebrafish (Danio rerio)	vox¹	--	ventral homeobox	57.78(n) 55(a)	64807 NM_131698.1 NP_571773.1
baker's yeast (Saccharomyces cerevisiae)	HMRA2(YCR096C)⁴	3(293535-293176)	Silenced copy of a2 at HMR; similarity to Alpha2p; more	--	850458 NP_010020.1

About this table Species with no ortholog for VENTX

ENSEMBL Gene Tree for VENTX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/81 NCBI SNPs in VENTX are shown (see all 81 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 84)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2240892^1,2	A,C,F,H	134901533(-)	`TCCCCA/GGGGAG`	1	L/P	mis¹ ese³		5	EA EU WA	1730
--	rs1054776^1,2	A,C,F,H	134905339(+)	`CAGGGA/GCTACT`	1	--	ut3¹ ese³		8	MN NA EU EA WA	736
--	rs2980729^1,2	A,C,F,H	134904894(+)	`CTTCTT/CGCAGA`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs3750849^1,2	A,C,F,H	134905241(-)	`CCTGAC/TGTTTA`	1	--	ut3¹ ese³		8	EA NA EU WA	2014
	rs2980717^1,2	F,H	134900468(+)	`GAGCAG/ACGGCC`	1	--	ng5¹		4	EU EA WA	408
	rs2240891^1,2	F,H	134901643(-)	`GGCCAT/CGGTCC`	1	V/M	mis¹ ese³		5	EA EU WA	1704
	rs3763770^1,2	F,H	134900103(-)	`AGCCTC/ACCGGG`	1	--	ng5¹		4	EU EA WA	420
--	rs9418952^1,2	F,H	134903594(+)	`TGTCCG/AGGCCC`	1	R/G	mis¹ ese³		4	EU EA WA	400
	rs2980716^1,2	H	134900051(+)	`GCTGAG/AGTCCC`	1	--	ng5¹		4	EU EA WA	418
	rs11101654^1,2	H	134901647(+)	`CATGGC/ACGGTA`	1	D/A	mis¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for VENTX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607158

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for VENTX gene:

A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. (PubMed id 10790436)^{1, 2, 3} Moreau-Aubry A.... Breathnach R. (2000)
Molecular cloning of a human Vent-like homeobox gene. (PubMed id 11549314)^{3, 4} Moretti P.A.B....D'Andrea R.J. (2001)
Classification and nomenclature of all human homeobox genes. (PubMed id 17963489)³ Holland P.W....Bruford E.A. (2007)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)⁴ Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 27287	HGNC: 13639	AceView: VENTX2	Ensembl:ENSG00000151650	euGenes: HUgn27287
ECgene: VENTX	H-InvDB: VENTX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for VENTX	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for VENTX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VENTX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VENTX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VENTX		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VENTX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VENTX)
	Antibodies (VENTX)
	Chimera RNAi (VENTX)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (VENTX)
	Antibodies (VENTX)

Search OriGene for VENTX

Search Tocris compounds for VENTX

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VENTX

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VENTX Gene at Home site.
Version 2.41.1
server5.xennexinc.com

VENTX Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for VENTX

Summaries
for VENTX

Genomic Location
for VENTX

Proteins
for VENTX

Protein Domains/
Families
for VENTX

Gene Function
for VENTX

Pathways & Interactions
for VENTX

Drugs & Compounds
for VENTX

Transcripts
for VENTX

Expression
for VENTX

Orthologs
for VENTX

Paralogs
for VENTX

SNPs/Variants
for VENTX

Disorders & Mutations
for VENTX

Medical News
for VENTX

Publications
for VENTX

Search for VENTX

Genome Databases showing VENTX

Other Databases showing VENTX

Specialized Databases showing VENTX

Licensable Technologies
for VENTX

Services
for VENTX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VENTX Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor VENTX

Summariesfor VENTX

Genomic Locationfor VENTX

Proteinsfor VENTX

Protein Domains/Familiesfor VENTX

Gene Functionfor VENTX

Pathways & Interactionsfor VENTX

Drugs & Compoundsfor VENTX

Transcriptsfor VENTX

Expression for VENTX

Orthologsfor VENTX

Paralogsfor VENTX

SNPs/Variantsfor VENTX

Disorders & Mutationsfor VENTX

Medical Newsfor VENTX

Publicationsfor VENTX

Search for VENTX

Genome Databases showing VENTX

Other Databases showing VENTX

Specialized Databases showing VENTX

Licensable Technologiesfor VENTX

Servicesfor VENTX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VENTX

Summaries
for VENTX

Genomic Location
for VENTX

Proteins
for VENTX

Protein Domains/
Families
for VENTX

Gene Function
for VENTX

Pathways & Interactions
for VENTX

Drugs & Compounds
for VENTX

Transcripts
for VENTX

Expression
for VENTX

Orthologs
for VENTX

Paralogs
for VENTX

SNPs/Variants
for VENTX

Disorders & Mutations
for VENTX

Medical News
for VENTX

Publications
for VENTX

Licensable Technologies
for VENTX

Services
for VENTX