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Aliases for VENTX Gene

Aliases for VENTX Gene

  • VENT Homeobox 2 3
  • VENTX2 3 4 6
  • HPX42B 3 4 6
  • VENT-Like Homeobox Protein 2 3 4
  • VENT Homeobox Homolog 3 4
  • VENT-Like Homeobox 2 2 3
  • Hemopoietic Progenitor Homeobox Protein VENTX2 3
  • VENT Homeobox Homolog (Xenopus Laevis) 2
  • Homeobox Protein VENTX 3
  • NA88A 3

External Ids for VENTX Gene

Previous HGNC Symbols for VENTX Gene

  • VENTX2

Previous GeneCards Identifiers for VENTX Gene

  • GC10P134941
  • GC10P135051
  • GC10P128597

Summaries for VENTX Gene

Entrez Gene Summary for VENTX Gene

  • This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for VENTX Gene

VENTX (VENT Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for VENTX Gene

  • May be involved in ventralization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VENTX Gene

Genomics for VENTX Gene

Regulatory Elements for VENTX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VENTX Gene

Start:
133,237,404 bp from pter
End:
133,241,930 bp from pter
Size:
4,527 bases
Orientation:
Plus strand

Genomic View for VENTX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VENTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VENTX Gene

Proteins for VENTX Gene

  • Protein details for VENTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95231-VENTX_HUMAN
    Recommended name:
    Homeobox protein VENTX
    Protein Accession:
    O95231
    Secondary Accessions:
    • Q32MZ3

    Protein attributes for VENTX Gene

    Size:
    258 amino acids
    Molecular mass:
    27552 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VENTX Gene

Proteomics data for VENTX Gene at MOPED

Post-translational modifications for VENTX Gene

No Post-translational modifications

Other Protein References for VENTX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VENTX Gene

Domains for VENTX Gene

Gene Families for VENTX Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for VENTX Gene

Suggested Antigen Peptide Sequences for VENTX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95231

UniProtKB/Swiss-Prot:

VENTX_HUMAN :
  • O95231
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with VENTX: view

Function for VENTX Gene

Molecular function for VENTX Gene

UniProtKB/Swiss-Prot Function: May be involved in ventralization

Gene Ontology (GO) - Molecular Function for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with VENTX: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VENTX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VENTX Gene

Localization for VENTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for VENTX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VENTX Gene COMPARTMENTS Subcellular localization image for VENTX gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with VENTX: view

Pathways for VENTX Gene

SuperPathways for VENTX Gene

No Data Available

Gene Ontology (GO) - Biological Process for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with VENTX: view

No data available for Pathways by source for VENTX Gene

Transcripts for VENTX Gene

mRNA/cDNA for VENTX Gene

(9) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VENTX Gene

VENT homeobox:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VENTX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VENTX
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VENTX Gene

No ASD Table

Relevant External Links for VENTX Gene

GeneLoc Exon Structure for
VENTX
ECgene alternative splicing isoforms for
VENTX

Expression for VENTX Gene

mRNA expression in normal human tissues for VENTX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VENTX Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VENTX Gene

SOURCE GeneReport for Unigene cluster for VENTX Gene Hs.125231

mRNA Expression by UniProt/SwissProt for VENTX Gene

O95231-VENTX_HUMAN
Tissue specificity: Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.
genes like me logo Genes that share expressions with VENTX: view

In Situ Assay Products

Orthologs for VENTX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VENTX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VENTX 35
  • 98.06 (n)
  • 96.9 (a)
VENTX 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VENTX 35
  • 70.24 (n)
  • 57.54 (a)
VENTX 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msx3 36
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VENTX 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii vent 36
  • 32 (a)
OneToMany
vox 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMRA2 38
Species with no ortholog for VENTX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VENTX Gene

ENSEMBL:
Gene Tree for VENTX (if available)
TreeFam:
Gene Tree for VENTX (if available)

Paralogs for VENTX Gene

Selected SIMAP similar genes for VENTX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VENTX: view

Variants for VENTX Gene

Sequence variations from dbSNP and Humsavar for VENTX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs880340 -- 133,239,619(-) GCTCG(C/T)GCCCA intron-variant
rs1054776 -- 133,241,845(+) CAGGG(A/G)CTACT utr-variant-3-prime
rs2240891 - 133,238,149(-) GGCCA(C/T)GGTCC reference, missense
rs2240892 - 133,238,039(-) TCCCC(A/C/G)GGGAG missense, reference
rs2270192 - 133,239,735(-) CTGCT(C/T)CATGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for VENTX Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv832038 CNV Gain+Loss 17160897
dgv878n71 CNV Loss 21882294
nsv896267 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
dgv881n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
nsv8750 CNV Gain+Loss 18304495
dgv883n71 CNV Loss 21882294
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294
nsv516968 CNV Loss 19592680
dgv886n71 CNV Gain 21882294

Relevant External Links for VENTX Gene

HapMap Linkage Disequilibrium report
VENTX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VENTX Gene

Disorders for VENTX Gene

No disorders were found for VENTX Gene.

No data available for UniProtKB/Swiss-Prot for VENTX Gene

Publications for VENTX Gene

  1. A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. (PMID: 10790436) Moreau-Aubry A. … Breathnach R. (J. Exp. Med. 2000) 2 3 23
  2. Molecular cloning of a human Vent-like homeobox gene. (PMID: 11549314) Moretti P.A.B. … D'Andrea R.J. (Genomics 2001) 3 4
  3. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for VENTX Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate VENTX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for VENTX
    • Block miRNA regulation of VENTX using miScript Target Protectors

    Sources for VENTX Gene

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