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Aliases for VENTX Gene

Aliases for VENTX Gene

  • VENT Homeobox 2 3 5
  • VENT-Like Homeobox Protein 2 3 4
  • VENT Homeobox Homolog 3 4
  • VENT-Like Homeobox 2 2 3
  • VENTX2 3 4
  • HPX42B 3 4
  • Hemopoietic Progenitor Homeobox Protein VENTX2 3
  • VENT Homeobox Homolog (Xenopus Laevis) 2
  • Homeobox Protein VENTX 3
  • NA88A 3

External Ids for VENTX Gene

Previous HGNC Symbols for VENTX Gene

  • VENTX2

Previous GeneCards Identifiers for VENTX Gene

  • GC10P134941
  • GC10P135051
  • GC10P128597

Summaries for VENTX Gene

Entrez Gene Summary for VENTX Gene

  • This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for VENTX Gene

VENTX (VENT Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is BARHL2.

UniProtKB/Swiss-Prot for VENTX Gene

  • May be involved in ventralization.

Additional gene information for VENTX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VENTX Gene

Genomics for VENTX Gene

Regulatory Elements for VENTX Gene

Enhancers for VENTX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H133257 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +23.0 23015 6 HDGF ATF1 SIN3A BRCA1 ZNF766 GLIS2 ELK1 ZNF143 FOS ATF7 TUBGCP2 VENTX ENSG00000235245 SCART1 ZNF511 ADAM8 ECHS1 ENSG00000273980
GH10H133273 1.8 FANTOM5 ENCODE dbSUPER 5.8 +39.8 39799 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB7B ZNF143 ZNF207 FOS JUNB ADAM8 TUBGCP2 ECHS1 VENTX ENSG00000235245 CFAP46 GC10P133285 PIR44208
GH10H133304 1.7 FANTOM5 ENCODE dbSUPER 5.6 +70.1 70081 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 TUBGCP2 ECHS1 VENTX ADAM8 ZNF511 GC10P133300
GH10H133334 1.2 Ensembl ENCODE 5.9 +98.4 98358 2 ATF1 ZNF473 ZSCAN4 KLF17 SIN3A GLI4 BMI1 ZNF23 GLIS2 EGR1 SCART1 ZNF511 PAOX ECHS1 TUBGCP2 VENTX MTG1 FUOM CALY GC10M133326
GH10H133247 1.1 ENCODE dbSUPER 6.3 +12.3 12282 5 HDGF ATF1 ARNT YBX1 NFXL1 ZNF48 RAD21 GLIS2 ZNF366 ATF7 TUBGCP2 SCART1 ENSG00000235245 ZNF511 VENTX PAOX ECHS1 MIR202HG ENSG00000273980
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VENTX on UCSC Golden Path with GeneCards custom track

Genomic Location for VENTX Gene

Chromosome:
10
Start:
133,237,404 bp from pter
End:
133,241,930 bp from pter
Size:
4,527 bases
Orientation:
Plus strand

Genomic View for VENTX Gene

Genes around VENTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VENTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VENTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VENTX Gene

Proteins for VENTX Gene

  • Protein details for VENTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95231-VENTX_HUMAN
    Recommended name:
    Homeobox protein VENTX
    Protein Accession:
    O95231
    Secondary Accessions:
    • Q32MZ3

    Protein attributes for VENTX Gene

    Size:
    258 amino acids
    Molecular mass:
    27552 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VENTX Gene

Post-translational modifications for VENTX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VENTX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for VENTX

No data available for DME Specific Peptides for VENTX Gene

Domains & Families for VENTX Gene

Gene Families for VENTX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for VENTX Gene

Suggested Antigen Peptide Sequences for VENTX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VENTX: view

No data available for UniProtKB/Swiss-Prot for VENTX Gene

Function for VENTX Gene

Molecular function for VENTX Gene

UniProtKB/Swiss-Prot Function:
May be involved in ventralization.

Gene Ontology (GO) - Molecular Function for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IMP 23332764
genes like me logo Genes that share ontologies with VENTX: view
genes like me logo Genes that share phenotypes with VENTX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VENTX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VENTX Gene

Localization for VENTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for VENTX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VENTX gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli fibrillar center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with VENTX: view

Pathways & Interactions for VENTX Gene

SuperPathways for VENTX Gene

No Data Available

Gene Ontology (GO) - Biological Process for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 21325273
genes like me logo Genes that share ontologies with VENTX: view

No data available for Pathways by source and SIGNOR curated interactions for VENTX Gene

Drugs & Compounds for VENTX Gene

No Compound Related Data Available

Transcripts for VENTX Gene

mRNA/cDNA for VENTX Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VENTX Gene

VENT homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VENTX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VENTX Gene

No ASD Table

Relevant External Links for VENTX Gene

GeneLoc Exon Structure for
VENTX
ECgene alternative splicing isoforms for
VENTX

Expression for VENTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VENTX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VENTX Gene

This gene is overexpressed in Whole Blood (x7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VENTX Gene



NURSA nuclear receptor signaling pathways regulating expression of VENTX Gene:

VENTX

SOURCE GeneReport for Unigene cluster for VENTX Gene:

Hs.125231

mRNA Expression by UniProt/SwissProt for VENTX Gene:

O95231-VENTX_HUMAN
Tissue specificity: Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.

Evidence on tissue expression from TISSUES for VENTX Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with VENTX: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VENTX Gene

Orthologs for VENTX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VENTX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VENTX 34 33
  • 98.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VENTX 34 33
  • 70.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Msx3 34
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VENTX 34
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii vent 34
  • 32 (a)
OneToMany
vox 34
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMRA2 36
Species where no ortholog for VENTX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VENTX Gene

ENSEMBL:
Gene Tree for VENTX (if available)
TreeFam:
Gene Tree for VENTX (if available)

Paralogs for VENTX Gene

Paralogs for VENTX Gene

(1) SIMAP similar genes for VENTX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VENTX: view

Variants for VENTX Gene

Sequence variations from dbSNP and Humsavar for VENTX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000354641 -- 133,241,669(+) GCTGC(A/G)TCCCC utr-variant-3-prime
rs1000678864 -- 133,238,560(+) AGCCG(C/G)TGCCT intron-variant
rs1001846022 -- 133,238,289(+) AGGGC(C/T)GGCGG intron-variant
rs1002891944 -- 133,239,143(+) GCCTT(C/T)CCTGG intron-variant
rs1003016440 -- 133,236,862(+) ACCCT(C/T)GGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VENTX Gene

Variant ID Type Subtype PubMed ID
dgv1474n54 CNV loss 21841781
dgv2e196 CNV duplication 17116639
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625030 CNV gain 21293372
esv3625035 CNV gain 21293372
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv470980 CNV loss 18288195
nsv516968 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952705 CNV deletion 24416366

Variation tolerance for VENTX Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VENTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VENTX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VENTX Gene

Disorders for VENTX Gene

Relevant External Links for VENTX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VENTX

No disorders were found for VENTX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VENTX Gene

Publications for VENTX Gene

  1. A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. (PMID: 10790436) Moreau-Aubry A … Breathnach R (The Journal of experimental medicine 2000) 2 3 22 60
  2. Molecular cloning of a human Vent-like homeobox gene. (PMID: 11549314) Moretti PA … D'Andrea RJ (Genomics 2001) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells. (PMID: 24706756) Wu X … Zhu Z (The Journal of biological chemistry 2014) 3 60

Products for VENTX Gene

Sources for VENTX Gene

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