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Aliases for VENTX Gene

Aliases for VENTX Gene

  • VENT Homeobox 2 3 5
  • VENT-Like Homeobox Protein 2 3 4
  • VENT Homeobox Homolog 3 4
  • VENT-Like Homeobox 2 2 3
  • VENTX2 3 4
  • HPX42B 3 4
  • Hemopoietic Progenitor Homeobox Protein VENTX2 3
  • VENT Homeobox Homolog (Xenopus Laevis) 2
  • NA88A 3

External Ids for VENTX Gene

Previous HGNC Symbols for VENTX Gene

  • VENTX2

Previous GeneCards Identifiers for VENTX Gene

  • GC10P134941
  • GC10P135051
  • GC10P128597

Summaries for VENTX Gene

Entrez Gene Summary for VENTX Gene

  • This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for VENTX Gene

VENTX (VENT Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for VENTX Gene

  • May be involved in ventralization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VENTX Gene

Genomics for VENTX Gene

Regulatory Elements for VENTX Gene

Enhancers for VENTX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VENTX on UCSC Golden Path with GeneCards custom track

Promoters for VENTX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VENTX on UCSC Golden Path with GeneCards custom track

Genomic Location for VENTX Gene

Chromosome:
10
Start:
133,237,404 bp from pter
End:
133,241,930 bp from pter
Size:
4,527 bases
Orientation:
Plus strand

Genomic View for VENTX Gene

Genes around VENTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VENTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VENTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VENTX Gene

Proteins for VENTX Gene

  • Protein details for VENTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95231-VENTX_HUMAN
    Recommended name:
    Homeobox protein VENTX
    Protein Accession:
    O95231
    Secondary Accessions:
    • Q32MZ3

    Protein attributes for VENTX Gene

    Size:
    258 amino acids
    Molecular mass:
    27552 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VENTX Gene

Proteomics data for VENTX Gene at MOPED

Post-translational modifications for VENTX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VENTX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for VENTX

No data available for DME Specific Peptides for VENTX Gene

Domains & Families for VENTX Gene

Gene Families for VENTX Gene

Protein Domains for VENTX Gene

Suggested Antigen Peptide Sequences for VENTX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95231

UniProtKB/Swiss-Prot:

VENTX_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with VENTX: view

Function for VENTX Gene

Molecular function for VENTX Gene

UniProtKB/Swiss-Prot Function:
May be involved in ventralization.

Gene Ontology (GO) - Molecular Function for VENTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with VENTX: view

Phenotypes for VENTX Gene

genes like me logo Genes that share phenotypes with VENTX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VENTX Gene

Localization for VENTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for VENTX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VENTX Gene COMPARTMENTS Subcellular localization image for VENTX gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for VENTX Gene

Pathways & Interactions for VENTX Gene

SuperPathways for VENTX Gene

No Data Available

Gene Ontology (GO) - Biological Process for VENTX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VENTX Gene

Drugs & Compounds for VENTX Gene

No Compound Related Data Available

Transcripts for VENTX Gene

mRNA/cDNA for VENTX Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VENTX Gene

VENT homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VENTX Gene

No ASD Table

Relevant External Links for VENTX Gene

GeneLoc Exon Structure for
VENTX
ECgene alternative splicing isoforms for
VENTX

Expression for VENTX Gene

mRNA expression in normal human tissues for VENTX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VENTX Gene

This gene is overexpressed in Whole Blood (x7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VENTX Gene



SOURCE GeneReport for Unigene cluster for VENTX Gene Hs.125231

mRNA Expression by UniProt/SwissProt for VENTX Gene

O95231-VENTX_HUMAN
Tissue specificity: Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.
genes like me logo Genes that share expression patterns with VENTX: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for VENTX Gene

Orthologs for VENTX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VENTX Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VENTX 35
  • 70.24 (n)
  • 57.54 (a)
VENTX 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VENTX 35
  • 98.06 (n)
  • 96.9 (a)
VENTX 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msx3 36
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VENTX 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii vent 36
  • 32 (a)
OneToMany
vox 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMRA2 38
Species with no ortholog for VENTX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VENTX Gene

ENSEMBL:
Gene Tree for VENTX (if available)
TreeFam:
Gene Tree for VENTX (if available)

Paralogs for VENTX Gene

(1) SIMAP similar genes for VENTX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VENTX: view

No data available for Paralogs for VENTX Gene

Variants for VENTX Gene

Sequence variations from dbSNP and Humsavar for VENTX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2240892 - 133,238,039(-) TCCCC(A/C/G)GGGAG reference, missense
rs2240891 - 133,238,149(-) GGCCA(C/T)GGTCC reference, missense
rs2270192 - 133,239,735(-) CTGCT(C/T)CATGG reference, missense
rs9418952 - 133,240,100(+) TGTCC(A/G)GGCCC reference, missense
rs9418953 - 133,240,269(+) CCGGG(A/G)CCTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for VENTX Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv832038 CNV Gain+Loss 17160897
dgv878n71 CNV Loss 21882294
nsv896267 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
dgv881n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
nsv8750 CNV Gain+Loss 18304495
dgv883n71 CNV Loss 21882294
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294
nsv516968 CNV Loss 19592680
dgv886n71 CNV Gain 21882294

Variation tolerance for VENTX Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VENTX Gene

Disorders for VENTX Gene

Relevant External Links for VENTX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VENTX

No disorders were found for VENTX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VENTX Gene

Publications for VENTX Gene

  1. A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. (PMID: 10790436) Moreau-Aubry A. … Breathnach R. (J. Exp. Med. 2000) 2 3 23 67
  2. Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells. (PMID: 24706756) Wu X. … Zhu Z. (J. Biol. Chem. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. (PMID: 22791709) Gao H. … Zhu Z. (J. Biol. Chem. 2012) 3
  5. VentX trans-activates p53 and p16ink4a to regulate cellular senescence. (PMID: 21325273) Wu X. … Zhu Z. (J. Biol. Chem. 2011) 3

Products for VENTX Gene

Sources for VENTX Gene

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