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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VENTX Gene

protein-coding   GIFtS: 48
GCID: GC10P135051

VENT Homeobox

(Previous names: VENT-like homeobox 2, VENT homeobox homolog (Xenopus laevis))
(Previous symbol: VENTX2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
VENT Homeobox1 2     VENT-Like Homeobox Protein 22 3
VENTX21 2 3 5     VENT Homeobox Homolog (Xenopus Laevis)1
HPX42B2 3 5     NA88A2
VENT-Like Homeobox 21 2     Hemopoietic Progenitor Homeobox Protein VENTX22
VENT Homeobox Homolog2 3     Homeobox Protein VENTX2

External Ids:    HGNC: 136391   Entrez Gene: 272872   Ensembl: ENSG000001516507   OMIM: 6071585   UniProtKB: O952313   

Export aliases for VENTX gene to outside databases

Previous GC identifers: GC10P134941 GC10P128597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VENTX Gene:
This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a
transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance.
Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen
production in certain melanomas. (provided by RefSeq, Jul 2008)

GeneCards Summary for VENTX Gene: 
VENTX (VENT homeobox) is a protein-coding gene. Diseases associated with VENTX include melanoma, and acute myeloid leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231
Function: May be involved in ventralization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VENTX gene promoter:
         AhR   Nkx3-1 v4   POU2F1   POU2F1a   HOXA5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVENTX promoter sequence
   Search SABiosciences Chromatin IP Primers for VENTX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VENTX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

VENTX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VENTX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135051:  view genomic region     (about GC identifiers)

Start:
135,050,908 bp from pter      End:
135,055,433 bp from pter
Size:
4,526 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231 (See protein sequence)
Recommended Name: Homeobox protein VENTX  
Size: 258 amino acids; 27552 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q32MZ3

Explore the universe of human proteins at neXtProt for VENTX: NX_O95231

Explore proteomics data for VENTX at MOPED 

VENTX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

VENTX Protein Expression

REFSEQ proteins: NP_055283.1  
ENSEMBL proteins: 
 ENSP00000357556  

Human Recombinant Protein Products for VENTX: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Purified Protein for VENTX
OriGene Protein Over-expression Lysate for VENTX
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Novus Biologicals VENTX Proteins
Novus Biologicals VENTX Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for VENTX 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

VENTX for ontologies           About GeneDecksing



VENTX Antibody Products: 
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Abcam antibodies for VENTX
Cloud-Clone Corp. Antibodies for VENTX 
ThermoFisher Antibodies for VENTX
LSBio Antibodies in human, mouse, rat for VENTX 

Assay Products for VENTX: 
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Cloud-Clone Corp. ELISAs for VENTX 
Cloud-Clone Corp. CLIAs for VENTX


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
NKL: Homeoboxes / ANTP class : NKL subclass

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O95231

ProtoNet protein and cluster: O95231

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231
Similarity: Contains 1 homeobox DNA-binding domain


VENTX for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: VENTX_HUMAN, O95231
Function: May be involved in ventralization

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
VENTX for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for VENTX 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VENTX

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VENTX 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VENTX 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VENTX
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VENTX
SwitchGear 3'UTR luciferase reporter plasmidVENTX 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for VENTX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VENTX

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for VENTX
Sirion Biotech Customized adenovirus for overexpression of VENTX

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for VENTX (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: VENTX (NM_014468)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for VENTX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VENTX
Sirion Biotech Customized lentivirus for stable overexpression of VENTX 
                     Customized lentivirus expression plasmids for stable overexpression of VENTX 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for VENTX
Search LifeMap BioReagents cell lines for VENTX
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VENTX


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VENTX

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for VENTX (O952313 ENSP000003575564) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
TLE1Q047243, ENSP000003656824I2D: score=1 STRING: ENSP00000365682
TLE2Q047253, ENSP000002629534I2D: score=1 STRING: ENSP00000262953
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-dependent ----
GO:0007275multicellular organismal development IEA--

VENTX for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VENTX

Search CenterWatch for drugs/clinical trials and news about VENTX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VENTX gene: 
NM_014468.3  

Unigene Cluster for VENTX:

VENT homeobox
Hs.125231  [show with all ESTs]
Unigene Representative Sequence: AF068006
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000325980(uc010quy.1)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VENTX
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VENTX
SwitchGear 3'UTR luciferase reporter plasmidVENTX 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for VENTX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VENTX
Clone
Products:
     
OriGene clones in human, mouse for VENTX (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: VENTX (NM_014468)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for VENTX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VENTX
Sirion Biotech Customized lentivirus for stable overexpression of VENTX 
                     Customized lentivirus expression plasmids for stable overexpression of VENTX 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for VENTX
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat VENTX
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VENTX
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VENTX

Additional mRNA sequence: 

AF068006.1 BC108915.1 BC108916.1 

1 DOTS entry:

DT.95220313 

9 AceView cDNA sequences:

AA973729 NM_014468 CA390754 BX089390 AF068006 BM676533 W37703 AA872096 
W37326 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VENTX expression in normal human tissues (normalized intensities)      VENTX embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
VENTX Expression
About this image


VENTX expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Inner Cell Mass (Early Embryonic Tissues)
         Line H9 (WA09)

See VENTX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VENTX

SOURCE GeneReport for Unigene cluster: Hs.125231

UniProtKB/Swiss-Prot: VENTX_HUMAN, O95231
Tissue specificity: Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an
erythroleukemia cell line

    SABiosciences Custom PCR Arrays for VENTX
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for VENTX
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat VENTX
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VENTX
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VENTX
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VENTX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for VENTX gene from 7/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia VENTX1 VENT homeobox 69.84(n)
57.14(a)
  100688982  XM_003433650.1  XP_003433698.1 
chicken
(Gallus gallus)
Aves VENTX6
VENT homeobox
17(a)
1 ↔ 1
6(21051932-21053666)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
51(a)
26(a)
many → 1
many → 1
GL343262.1(400035-402452)
GL343262.1(342148-346774)
African clawed frog
(Xenopus laevis)
Amphibia U43938.12   -- 73.74(n)    U43938.1 
zebrafish
(Danio rerio)
Actinopterygii vent6
vox6
(see all 3)
ventral homeobox
(see all 3)
26(a)
23(a)
(see all 3)
many → 1
many → 1
(see all 3)
13(54056772-54063429)
13(54046956-54049197)
fruit fly
(Drosophila melanogaster)
Insecta eve6
even skipped
11(a)
1 → many
2R(5866824-5868300)
worm
(Caenorhabditis elegans)
Secernentea vab-76
Homeobox protein vab-7
16(a)
1 → many
III(10920336-10926041)


ENSEMBL Gene Tree for VENTX (if available)
TreeFam Gene Tree for VENTX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for VENTX gene
DLX22  BARX12  NKX1-12  BARHL12  BARHL22  BARX22  DLX12  DLX32  
LBX22  NKX1-22  BSX2  DLX52  DLX62  DLX42  LBX12  MSX22  
MSX12  
1 SIMAP similar gene for VENTX using alignment to 1 protein entry:     VENTX_HUMAN:
VENTX1

VENTX for paralogs           About GeneDecksing


5/7 Pseudogenes.org Pseudogenes for VENTX (see all 7)
PGOHUM00000239855 PGOHUM00000248448 PGOHUM00000237560 PGOHUM00000237957 PGOHUM00000249291


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/216 SNPs in VENTX are shown (see all 216)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1817100721,2
--135049438(+) GTGGGA/GGTGCT 1 -- us2k10--------
rs1871300501,2
--135049486(+) TGGGCC/TCCGGA 1 -- us2k10--------
rs1918152661,2
--135049574(+) GGAAGC/TTTCTG 1 -- us2k10--------
rs1408757241,2
--135049589(+) TTTTCC/TCTGCC 1 -- us2k10--------
rs29807151,2
H--135049984(+) AACCAG/AGGTCA 1 -- us2k14Minor allele frequency- A:0.00NS EA 414
rs29807161,2
C,H--135050061(+) GCTGAG/AGTCCC 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
rs37637701,2
F,H--135050113(-) AGCCTC/ACCGGG 1 -- us2k14Minor allele frequency- A:0.01NS EA 420
rs1179902041,2
F--135050159(+) CCCGCC/TGGTCT 1 -- us2k11Minor allele frequency- T:0.01EA 120
rs357728101,2
F--135050287(-) GCGCAG/TGTCCG 1 -- us2k11Minor allele frequency- T:0.33NA 6
rs29807171,2
C,F,H--135050478(+) GAGCAG/ACGGCC 1 -- us2k16Minor allele frequency- A:0.01NS EA NA 414

HapMap Linkage Disequilibrium report for VENTX (135050908 - 135055433 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/24 variations for VENTX (see all 24):    About this table     
Variant IDTypeSubtypePubMed ID
dgv2e196CNV Duplication17116639
nsv832036CNV Loss17160897
nsv896267CNV Loss21882294
dgv879n71CNV Loss21882294
nsv832039CNV Loss17160897
dgv884n71CNV Loss21882294
nsv896258CNV Loss21882294
dgv882n71CNV Loss21882294
dgv880n71CNV Loss21882294
nsv896182CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing VENTX
DNA2.0 Custom Variant and Variant Library Synthesis for VENTX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607158    OMIM disorders: --

4 diseases for VENTX:    About MalaCards
melanoma    acute myeloid leukemia    myeloid leukemia    leukemia


VENTX for disorders           About GeneDecksing


Export disorders for VENTX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for VENTX gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with VENTX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. (PubMed id 10790436)1, 3, 9 Moreau-Aubry A.... Breathnach R. (2000)
  2. Molecular cloning of a human Vent-like homeobox gene. (PubMed id 11549314)1, 2 Moretti P.A.B....D'Andrea R.J. (2001)
  3. Suppression of homeobox transcription factor VentX pro motes expansion of human hematopoietic stem/multipotent progenitor cells. (PubMed id 22791709)1 Gao H....Zhu Z. (2012)
  4. VentX trans-activates p53 and p16ink4a to regulate ce llular senescence. (PubMed id 21325273)1 Wu X....Zhu Z. (2011)
  5. The homeobox transcription factor VentX controls huma n macrophage terminal differentiation and proinflammatory activation. (PubMed id 21670496)1 Wu X....Zhu Z. (2011)
  6. VentX, a novel lymphoid-enhancing factor/T-cell facto r-associated transcription repressor, is a putative tumor suppressor. (PubMed id 20028861)1 Gao H....Zhu Z. (2010)
  7. The vent-like homeobox gene VENTX promotes human myel oid differentiation and is highly expressed in acute myeloid leukemia. (PubMed id 20833819)1 Rawat V.P....Feuring-Buske M. (2010)
  8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
  9. Classification and nomenclature of all human homeobox genes. (PubMed id 17963489)1 Holland P.W.H.... Bruford E.A. (2007)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 27287 HGNC: 13639 AceView: VENTX2 Ensembl:ENSG00000151650 euGenes: HUgn27287
ECgene: VENTX H-InvDB: VENTX

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for VENTX Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for VENTX Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for VENTX gene:
Search GeneIP for patents involving VENTX

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VENTX  
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 OriGene Custom Antibody Services for VENTX   OriGene Custom Protein Services for VENTX  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VENTX
 QIAGEN SeqTarget long-range PCR primers for resequencing VENTX
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VENTX
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VENTX
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 GenScript Custom Purified and Recombinant Proteins Services for VENTX GenScript cDNA clones with any tag delivered in your preferred vector for VENTX
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 Regulatory tfbs in VENTX promoter
 Search Chromatin IP Primers for VENTX
 RT2 qPCR Primer Assay in human, mouse / rat VENTX
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 Browse Sino Biological Proteins and Antibodies
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for VENTX
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 Proteins for VENTX
 Antibodies for VENTX
 ELISAs for VENTX
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 Search LifeMap BioReagents cell lines for VENTX
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VENTX
 SwitchGear 3'UTR luciferase reporter plasmids for VENTX
 SwitchGear Promoter luciferase reporter plasmids for VENTX
 ThermoFisher Antibodies for VENTX
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VENTX
 inGenious Targeting Laboratory - Custom generated mouse model solutions for VENTX
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VENTX
Customized:
 lentivirus for stable overexpression of VENTX
 lentivirus expression plasmids for stable overexpression of VENTX
 adenovirus for overexpression of VENTX
 LSBio Antibodies in human, mouse, rat for VENTX
Customized transgenic rodents for:
 Humanization
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 Tissue-specific gene expresssion
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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