Aliases for VEGFD Gene
External Ids for VEGFD Gene
Previous HGNC Symbols for VEGFD Gene
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
GeneCards Summary for VEGFD Gene
VEGFD (Vascular Endothelial Growth Factor D) is a Protein Coding gene. Diseases associated with VEGFD include Breast Cancer and Anal Canal Squamous Cell Carcinoma. Among its related pathways are VEGF binds to VEGFR leading to receptor dimerization and p70S6K Signaling. An important paralog of this gene is VEGFC.
UniProtKB/Swiss-Prot for VEGFD Gene
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.