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Aliases for VEGFC Gene

Aliases for VEGFC Gene

  • Vascular Endothelial Growth Factor C 2 3
  • Vascular Endothelial Growth Factor-Related Protein 2 3 4
  • Flt4-L 3 4
  • VRP 3 4
  • FLT4 Ligand DHM 3
  • Flt4 Ligand 4
  • LMPH1D 3
  • VEGF-C 4

External Ids for VEGFC Gene

Previous GeneCards Identifiers for VEGFC Gene

  • GC04M178492
  • GC04M178154
  • GC04M178300
  • GC04M177979
  • GC04M177841
  • GC04M177604
  • GC04M173355

Summaries for VEGFC Gene

Entrez Gene Summary for VEGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

GeneCards Summary for VEGFC Gene

VEGFC (Vascular Endothelial Growth Factor C) is a Protein Coding gene. Diseases associated with VEGFC include lymphedema, hereditary, id and breast carcinoma in situ. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include growth factor activity and vascular endothelial growth factor receptor 3 binding. An important paralog of this gene is FIGF.

UniProtKB/Swiss-Prot for VEGFC Gene

  • Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Gene Wiki entry for VEGFC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFC Gene

Genomics for VEGFC Gene

Regulatory Elements for VEGFC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VEGFC Gene

Start:
176,683,538 bp from pter
End:
176,792,745 bp from pter
Size:
109,208 bases
Orientation:
Minus strand

Genomic View for VEGFC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VEGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFC Gene

Proteins for VEGFC Gene

  • Protein details for VEGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49767-VEGFC_HUMAN
    Recommended name:
    Vascular endothelial growth factor C
    Protein Accession:
    P49767
    Secondary Accessions:
    • B2R9Q8

    Protein attributes for VEGFC Gene

    Size:
    419 amino acids
    Molecular mass:
    46883 Da
    Quaternary structure:
    • Homodimer; non-covalent and antiparallel.

    Three dimensional structures from OCA and Proteopedia for VEGFC Gene

neXtProt entry for VEGFC Gene

Proteomics data for VEGFC Gene at MOPED

Post-translational modifications for VEGFC Gene

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions
  • Glycosylation at Asn175, Asn205, and Asn240
  • Modification sites at PhosphoSitePlus

Other Protein References for VEGFC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VEGFC (VEGFC)

Protein Products

No data available for DME Specific Peptides for VEGFC Gene

Domains for VEGFC Gene

Suggested Antigen Peptide Sequences for VEGFC Gene

Graphical View of Domain Structure for InterPro Entry

P49767

UniProtKB/Swiss-Prot:

VEGFC_HUMAN :
  • P49767
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFC: view

No data available for Gene Families for VEGFC Gene

Function for VEGFC Gene

Molecular function for VEGFC Gene

GENATLAS Biochemistry: vascular endothelial growth factor C,expressed in heart,placenta,ovary,small intestine,with two alternatively spliced forms,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL
UniProtKB/Swiss-Prot Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

LifeMap Function Summary for VEGFC Gene

During embryonic development, VEGFC as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21130043
GO:0008083 growth factor activity IEA --
GO:0042056 chemoattractant activity IDA 19275959
GO:0043185 vascular endothelial growth factor receptor 3 binding IEA --
genes like me logo Genes that share ontologies with VEGFC: view
genes like me logo Genes that share phenotypes with VEGFC: view

Animal Model Products

CRISPR Products

miRNA for VEGFC Gene

miRTarBase miRNAs that target VEGFC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VEGFC Gene

Localization for VEGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEGFC Gene COMPARTMENTS Subcellular localization image for VEGFC gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with VEGFC: view

Pathways for VEGFC Gene

genes like me logo Genes that share pathways with VEGFC: view

PCR Array Products

Interacting Proteins for VEGFC Gene

Selected Interacting proteins: P49767-VEGFC_HUMAN for VEGFC Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0002576 platelet degranulation TAS --
GO:0006929 substrate-dependent cell migration TAS 8617204
genes like me logo Genes that share ontologies with VEGFC: view

Compounds for VEGFC Gene

(27) Novoseek inferred chemical compound relationships for VEGFC Gene

Compound -log(P) Hits PubMed IDs
vegf 89.2 262
tyrosine 50.2 42
matrigel 46.4 3
paraffin 24.2 5
trastuzumab 12.3 5
genes like me logo Genes that share compounds with VEGFC: view

Transcripts for VEGFC Gene

mRNA/cDNA for VEGFC Gene

(82) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VEGFC Gene

Vascular endothelial growth factor C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEGFC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFC Gene

No ASD Table

Relevant External Links for VEGFC Gene

GeneLoc Exon Structure for
VEGFC
ECgene alternative splicing isoforms for
VEGFC

Expression for VEGFC Gene

mRNA expression in normal human tissues for VEGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VEGFC Gene

SOURCE GeneReport for Unigene cluster for VEGFC Gene Hs.435215

mRNA Expression by UniProt/SwissProt for VEGFC Gene

P49767-VEGFC_HUMAN
Tissue specificity: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte
genes like me logo Genes that share expressions with VEGFC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VEGFC Gene

Orthologs for VEGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VEGFC 35
  • 99.6 (n)
  • 99.52 (a)
VEGFC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VEGFC 35
  • 90.29 (n)
  • 88.31 (a)
VEGFC 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEGFC 35
  • 90.53 (n)
  • 89.98 (a)
VEGFC 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vegfc 35
  • 87.71 (n)
  • 86.27 (a)
Vegfc 16
Vegfc 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VEGFC 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vegfc 35
  • 87.55 (n)
  • 85.54 (a)
chicken
(Gallus gallus)
Aves VEGFC 35
  • 79.78 (n)
  • 76.02 (a)
VEGFC 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEGFC 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vegfc 35
  • 74.98 (n)
  • 74.28 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26450 35
vegfc 35
  • 63.94 (n)
  • 60.87 (a)
vegfc 36
  • 58 (a)
OneToOne
Species with no ortholog for VEGFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFC Gene

ENSEMBL:
Gene Tree for VEGFC (if available)
TreeFam:
Gene Tree for VEGFC (if available)

Paralogs for VEGFC Gene

Paralogs for VEGFC Gene

Selected SIMAP similar genes for VEGFC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VEGFC: view

Variants for VEGFC Gene

Sequence variations from dbSNP and Humsavar for VEGFC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs18131 -- 176,748,937(+) CATAT(A/G)GAATA intron-variant
rs472353 -- 176,716,489(-) AGAAA(C/T)TCTCC intron-variant
rs475106 -- 176,735,636(-) TGTGT(C/T)TCACA intron-variant
rs475920 -- 176,716,124(-) TAACA(A/C)AAATT intron-variant
rs485561 -- 176,750,378(+) ATTTG(C/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFC Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
nsv881066 CNV Loss 21882294
nsv4613 CNV Insertion 18451855
esv1655976 CNV Deletion 17803354
esv2728777 CNV Deletion 23290073
nsv289896 CNV Loss 16902084
esv2658768 CNV Deletion 23128226
esv2670195 CNV Deletion 23128226
nsv822850 CNV Gain 20364138

Relevant External Links for VEGFC Gene

HapMap Linkage Disequilibrium report
VEGFC
Human Gene Mutation Database (HGMD)
VEGFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFC Gene

Disorders for VEGFC Gene

UniProtKB/Swiss-Prot

VEGFC_HUMAN
  • Lymphedema, hereditary, 1D (LMPH1D) [MIM:615907]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:23410910, ECO:0000269 PubMed:24744435}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for VEGFC Gene

(95) Novoseek inferred disease relationships for VEGFC Gene

Disease -log(P) Hits PubMed IDs
lymphatic metastasis 92.8 95
metastasis 82.2 364
congenital lymphedema 72.8 5
lymphedema 72.7 19
lymphatic vessel tumors 70.6 3

Relevant External Links for VEGFC

Genetic Association Database (GAD)
VEGFC
Human Genome Epidemiology (HuGE) Navigator
VEGFC
genes like me logo Genes that share disorders with VEGFC: view

Publications for VEGFC Gene

  1. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PMID: 8617204) Joukov V. … Alitalo K. (EMBO J. 1996) 2 3 4 23
  2. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PMID: 8612600) Joukov V. … Alitalo K. (EMBO J. 1996) 3 4 23
  3. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. (PMID: 8700872) Lee J. … Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  4. Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. (PMID: 19002718) Connell F.C. … Jeffery S. (Hum. Genet. 2009) 3 23 48
  5. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PMID: 20145116) Leppanen V.M. … Alitalo K. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 23

Products for VEGFC Gene

Sources for VEGFC Gene

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