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VEGFC Gene

protein-coding   GIFtS: 69
GCID: GC04M177604

Vascular Endothelial Growth Factor C

  See VEGFC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vascular Endothelial Growth Factor C1 2     VRP2 3
Vascular Endothelial Growth Factor-Related Protein1 2 3     FLT4 Ligand DHM2
Flt4-L2 3     Flt4 Ligand3
VEGF-C2 3     

External Ids:    HGNC: 126821   Entrez Gene: 74242   Ensembl: ENSG000001506307   OMIM: 6015285   UniProtKB: P497673   

Export aliases for VEGFC gene to outside databases

Previous GC identifers: GC04M178492 GC04M178154 GC04M178300 GC04M177979 GC04M177841 GC04M173355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VEGFC Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth
factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the
permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating
multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and
activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth
factor D. (provided by RefSeq, Jul 2008)

GeneCards Summary for VEGFC Gene:
VEGFC (vascular endothelial growth factor C) is a protein-coding gene. Diseases associated with VEGFC include breast carcinoma in situ, and lymphangiomatosis. GO annotations related to this gene include growth factor activity and vascular endothelial growth factor receptor 3 binding. An important paralog of this gene is FIGF.

UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and
migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous
and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic
endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

Gene Wiki entry for VEGFC (Vascular endothelial growth factor C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the VEGFC gene promoter:
         NF-1   NF-1/L   HOXA3   p53   Nkx2-5   Tal-1beta   Cdc5   GATA-1   Evi-1   GATA-6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVEGFC promoter sequence
   Search Chromatin IP Primers for VEGFC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VEGFC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.3   Ensembl cytogenetic band:  4q34.3   HGNC cytogenetic band: 4q34.3

VEGFC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M177604:  view genomic region     (about GC identifiers)

Start:
177,604,689 bp from pter      End:
177,713,895 bp from pter
Size:
109,207 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767 (See protein sequence)
Recommended Name: Vascular endothelial growth factor C precursor  
Size: 419 amino acids; 46883 Da
Subunit: Homodimer; non-covalent and antiparallel
3 PDB 3D structures from and Proteopedia for VEGFC:
2X1W (3D)        2X1X (3D)        4BSK (3D)    
Secondary accessions: B2R9Q8

Explore the universe of human proteins at neXtProt for VEGFC: NX_P49767

Explore proteomics data for VEGFC at MOPED

Post-translational modifications: 

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased
    activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an
    antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228
    producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide.
    Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent
    interactions1
  • Glycosylation2 at Asn175, Asn205, Asn240
  • Modification sites at PhosphoSitePlus

  • See VEGFC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005420.1  
    ENSEMBL proteins: 
     ENSP00000280193  
    Reactome Protein details: P49767

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    Sino Biological Cell Lysate for VEGFC
    ProSpec Recombinant Protein for VEGFC
    Cloud-Clone Corp. Proteins for VEGFC

     
    Search eBioscience for Proteins for VEGFC 

     
    antibodies-online proteins for VEGFC (77 products) 

     
    antibodies-online peptides for VEGFC

    VEGFC Antibody Products:

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    antibodies-online antibodies for VEGFC (132 products) 

    VEGFC Assay Products:

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    Cloud-Clone Corp. CLIAs for VEGFC
    eBioscience ELISAs for VEGFC:  
                        Human VEGF-C Platinum ELISA 96 tests
    antibodies-online kits for VEGFC (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR004153 CXCXC_repeat
     IPR000072 PDGF/VEGF_dom

    Graphical View of Domain Structure for InterPro Entry P49767

    ProtoNet protein and cluster: P49767

    3 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB004153 CXCXC repeat


    UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Find genes that share domains with VEGFC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFC_HUMAN, P49767
    Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and
    migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous
    and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic
    endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

         Genatlas biochemistry entry for VEGFC:
    vascular endothelial growth factor C,expressed in heart,placenta,ovary,small intestine,with two alternatively
    spliced forms,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL

         Summary: 
    During embryonic development, VEGFC as signaling molecule is secreted from the following cells:
                
    Endothelium: Venous Endothelial Cells (Veins)

    It affects the following cells:
    Lymph: Lymphatic Endothelial Cells (Lymphatic Vessels)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008083growth factor activity IEA--
    GO:0042056chemoattractant activity IDA19275959
    GO:0043185vascular endothelial growth factor receptor 3 binding IEA--
         
    Find genes that share ontologies with VEGFC           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for VEGFC:
     Decreased focal adhesion (FA)   Stronger migration 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vegfc):
     cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with VEGFC           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VEGFC

    miRNA
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    miRTarBase miRNAs that target VEGFC:
    hsa-mir-1826 (MIRT006603), hsa-mir-128-3p (MIRT021989)

    Block miRNA regulation of human, mouse, rat VEGFC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VEGFC (see all 13):
    hsa-miR-3163 hsa-miR-16-2* hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374c hsa-miR-338-5p hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidVEGFC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VEGFC

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: VEGFC (NM_005429)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFC

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    eBioscience FlowRNA Probe Sets ( VA1-14030) for VEGFC 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VEGFC_HUMAN, P49767: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--

    Find genes that share ontologies with VEGFC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VEGFC About   (see all 33)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    VEGF Pathway0.66
    2Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38


    Find genes that share SuperPaths with VEGFC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VEGFC (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for VEGFC
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for VEGFC
        Development VEGF-family signaling

    4 BioSystems Pathways for VEGFC
        Focal Adhesion
    Heart Development
    Signaling events mediated by VEGFR1 and VEGFR2
    VEGFR3 signaling in lymphatic endothelium

    1 Sino Biological Pathway for VEGFC
        VEGF Signaling

    3 Reactome Pathways for VEGFC
        VEGF ligand-receptor interactions
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation

    1 PharmGKB Pathway for VEGFC
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for VEGFC) (see all 7):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFC (see all 6): 
              mTOR Signaling in human mouse rat
              Growth Factors in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VEGFC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VEGFC (P497671, 3 ENSP000002801934) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT4P359161, 3, ENSP000002619374EBI-3405539,EBI-1005467 I2D: score=3 STRING: ENSP00000261937
    KDRP359683, ENSP000002639234I2D: score=2 STRING: ENSP00000263923
    ALBENSP000002958974STRING: ENSP00000295897
    APPENSP000002849814STRING: ENSP00000284981
    CRKENSP000003005744STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006929substrate-dependent cell migration TAS8617204
    GO:0007165signal transduction TAS8617204

    Find genes that share ontologies with VEGFC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VEGFC

    Selected Novoseek inferred chemical compound relationships for VEGFC gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 89.2 484 15637689 (10), 11579392 (9), 17536453 (9), 16961284 (8) (see all 99)
    tyrosine 50.2 45 8700872 (2), 8617204 (2), 8612600 (1), 11106244 (1) (see all 40)
    matrigel 46.4 3 19825968 (1), 16687456 (1), 20080299 (1)
    paraffin 24.2 6 16299237 (1), 17970053 (1), 19280060 (1), 15816493 (1) (see all 5)
    trastuzumab 12.3 5 17425844 (2), 18509974 (2), 12471041 (1)
    estrogen 9.18 10 11948478 (4), 11106244 (1), 16080559 (1), 16418144 (1) (see all 5)
    oligonucleotide 8.35 11 12594815 (1), 17393109 (1), 12479067 (1), 20137690 (1)
    dexamethasone 5.28 6 17062674 (5), 9525952 (1)
    testosterone 4.89 16 16964283 (4), 15897888 (3)
    glyceraldehyde 3-phosphate 3.08 2 18945297 (1)



    Find genes that share compounds with VEGFC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VEGFC gene: 
    NM_005429.3  

    Unigene Cluster for VEGFC:

    Vascular endothelial growth factor C
    Hs.435215  [show with all ESTs]
    Unigene Representative Sequence: NM_005429
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280193(uc003ius.1) ENST00000507638
    miRNA
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    hsa-miR-3163 hsa-miR-16-2* hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374c hsa-miR-338-5p hsa-miR-369-3p
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    Primer
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    Additional mRNA sequence: 

    AK313879.1 BC035212.1 BC063685.1 CR541897.1 U43142.1 U58111.1 X94216.1 

    2 DOTS entries:

    DT.444976  DT.92421196 

    Selected AceView cDNA sequences (see all 82):

    AA425303 Z40230 CA488579 U43142 AA479987 NM_005429 BC063685 CK904861 
    BE041634 Z44272 AI753125 BM055226 AI168770 X94216 BM310845 BQ020806 
    AW341345 BM127468 BE218812 AW195617 AW294293 U58111 BU615444 CK904860 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VEGFC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAATATGT
    VEGFC Expression
    About this image


    VEGFC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Endothelium (Cardiovascular System)
             Lymphatic Endothelial Cells Lymphatic Vessels
     
     Lymph (Hematopoietic System)
             Lymphatic Endothelial Cells Lymphatic Vessels
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
    VEGFC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VEGFC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435215

    UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
    Tissue specificity: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle,
    prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood
    lymphocyte

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFC (see all 6): 
              mTOR Signaling in human mouse rat
              Growth Factors in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFC gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vegfc1 , 5 vascular endothelial growth factor C1, 5 87.71(n)1
    86.27(a)1
      8 (29.20 cM)5
    223411  NM_009506.21  NP_033532.11 
     540775325 
    chicken
    (Gallus gallus)
    Aves VEGFC1 vascular endothelial growth factor C 79.78(n)
    76.02(a)
      422573  XM_420532.4  XP_420532.2 
    lizard
    (Anolis carolinensis)
    Reptilia VEGFC6
    vascular endothelial growth factor C
    74(a)
    1 ↔ 1
    5(117244071-117296116)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vegfc1 vascular endothelial growth factor C 74.98(n)
    74.28(a)
      100487606  XM_002933317.2  XP_002933363.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.264502 Danio rerio vascular endothelial growth factor C mRNA, more 76.09(n)    AF466147.1 


    ENSEMBL Gene Tree for VEGFC (if available)
    TreeFam Gene Tree for VEGFC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VEGFC gene
    FIGF2  
    1 SIMAP similar gene for VEGFC using alignment to 2 protein entries:     VEGFC_HUMAN (see all proteins):
    FIGF

    Find genes that share paralogs with VEGFC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VEGFC (see all 2133)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013973921,2
    --177376600(+) TTTAG-/TTTTTT 1 -- ds50010--------
    rs749212711,2
    C--177376610(+) TTTTTA/TAAATG 1 -- ds50010--------
    rs778937771,2
    C,F--177376615(+) AAAATG/ATATTG 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs730075321,2
    C,F--177376683(+) TTGGAA/GAAGAT 1 -- ds50012Minor allele frequency- G:0.02WA 120
    rs176516451,2
    C,F,H--177377036(+) GTTTTC/TGTTCA 1 -- ds50018Minor allele frequency- T:0.01NA NS 866
    rs1820577761,2
    --177377057(+) TGATAA/CTGGAC 1 -- ds50010--------
    rs413677441,2
    C--177377418(-) AAACTG/ATGTTG 1 -- ut313Minor allele frequency- A:0.04NA CSA WA 168
    rs1853010821,2
    C--177377431(+) CATAAC/TAGAAA 1 -- ut310--------
    rs1908935471,2
    --177377436(+) TAGAAA/GATCGA 1 -- ut310--------
    rs2021231991,2
    C--177377448(+) GAACTG/AGAAAA 1 -- ut311Minor allele frequency- A:0.00EU 1321

    HapMap Linkage Disequilibrium report for VEGFC (177604689 - 177713895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for VEGFC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1655976CNV Deletion17803354
    esv2658768CNV Deletion23128226
    esv2728772CNV Deletion23290073
    esv2670195CNV Deletion23128226
    esv2728777CNV Deletion23290073
    nsv4613CNV Insertion18451855
    nsv881066CNV Loss21882294
    nsv289896CNV Loss16902084
    nsv822850CNV Gain20364138

    Human Gene Mutation Database (HGMD): VEGFC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VEGFC
    DNA2.0 Custom Variant and Variant Library Synthesis for VEGFC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601528    OMIM disorders: --

    14 diseases for VEGFC:    
    About MalaCards
    breast carcinoma in situ    lymphangiomatosis    hereditary lymphedema    twin-to-twin transfusion syndrome
    cervical cancer    angiosarcoma    lymphangioleiomyomatosis    lymphangioma
    lymphedema    cervical intraepithelial neoplasia    laryngeal carcinoma    cholangiocarcinoma
    papillary thyroid carcinoma    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for VEGFC:
    Lymphedema     Carcinoma     Lung cancer     Breast cancer

    Find genes that share disorders with VEGFC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VEGFC gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphatic metastasis 92.8 130 15025957 (5), 14724935 (4), 20137690 (4), 18353210 (3) (see all 69)
    metastasis 82.2 811 19080076 (7), 15040017 (7), 18295452 (7), 15302715 (7) (see all 99)
    congenital lymphedema 72.8 5 19002718 (2), 19093784 (1), 12162200 (1), 11175851 (1)
    lymphedema 72.7 29 19302023 (4), 18269031 (3), 17176124 (2), 12235206 (2) (see all 12)
    lymphatic vessel tumors 70.6 4 16562672 (2), 16540684 (1)
    tumors 70.2 641 19608016 (6), 9665470 (5), 12566318 (5), 11477575 (5) (see all 99)
    carcinoma squamous cell 61.7 102 14613645 (5), 15272284 (4), 15656516 (4), 17354029 (3) (see all 48)
    cancer 60.3 157 16482630 (5), 11291931 (4), 16755294 (3), 10430087 (3) (see all 94)
    nsclc 59.1 155 16755294 (7), 12875690 (7), 16159440 (5), 15173661 (5) (see all 31)
    primary tumor 58.1 59 20137690 (6), 16474989 (3), 16843872 (3), 12660643 (2) (see all 31)

    Genetic Association Database (GAD): VEGFC
    Human Genome Epidemiology (HuGE) Navigator: VEGFC (17 documents)

    Export disorders for VEGFC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VEGFC gene, integrated from 10 sources (see all 864):
    (articles sorted by number of sources associating them with VEGFC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PubMed id 8617204)1, 2, 3, 9 Joukov V.... Alitalo K. (EMBO J. 1996)
    2. Characterization of murine Flt4 ligand/VEGF-C. (PubMed id 9247316)1, 2, 9 Fitz L.J.... Wood C.R. (Oncogene 1997)
    3. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PubMed id 20145116)1, 2, 9 Leppanen V.M.... Alitalo K. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    4. Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. (PubMed id 19002718)1, 4, 9 Connell F.C....Jeffery S. (Hum. Genet. 2009)
    5. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. (PubMed id 8700872)1, 2, 9 Lee J.... Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    6. Allelic variations in angiogenic pathway genes are associated with preeclampsia. (PubMed id 20223440)1, 4, 9 Srinivas S.K....Elovitz M.A. (Am. J. Obstet. Gynecol. 2010)
    7. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PubMed id 8612600)1, 2, 9 Joukov V....Alitalo K. (EMBO J. 1996)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. (PubMed id 20215856)1, 4 Hong J.M....Kim S.Y. (amp 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7424 HGNC: 12682 AceView: VEGFC Ensembl:ENSG00000150630 euGenes: HUgn7424
    ECgene: VEGFC Kegg: 7424 H-InvDB: VEGFC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VEGFC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VEGFC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VEGFC gene:
    Search GeneIP for patents involving VEGFC

    Licensable Technologies for VEGFC gene:
    Weizmann Institute:A Novel target for regulating lymphangiogenesis and lymph-node metastasis    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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