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Aliases & Descriptions for VEGFB
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| VEGF-B 3 | | VEGFL 1, 2 | | VRF 2, 3, 5 |
| | | Descriptions |
|---|
| VEGF-related factor 3 | | vascular endothelial growth factor B 2 |
|
| | Search outside databases for aliases for VEGFB genePrevious GC identifers: GC11P066518 GC11P065683 GC11P064253 GC11P063777 |
Summaries for VEGFB(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysisGene Wiki entry for VEGFB (Vascular_endothelial_growth_factor_B) |
Genomic Location for VEGFB
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VEGFB gene 
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13VEGFB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063758:
(about GC identifiers)
Start:
|
63,758,842 bp from pter |
End:
|
63,762,835 bp from pter |
Size:
|
3,994 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for VEGFB
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765 (See
protein sequence)Recommended Name: Vascular endothelial growth factor B precursor Size: 207 amino acids; 21602 Da
Subunit: Homodimer; disulfide-linked. Can also form heterodimer with VEGF
Subcellular location: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin
PDB structure from and Proteopedia :2C7W (3D)
 2VWE (3D)
 
Secondary accessions: Q16528Alternative splicing: 2 isoforms: P49765-1 P49765-2 (Additional isoforms seem to exist)Post-translational modifications:
VEGF-B186 is O-glycosylated (By similarity)1
REFSEQ proteins: NP_003368.1
ENSEMBL proteins: ENSP00000311127
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VEGFB 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VEGFB: Assays for VEGFB: | Protein
Domains/ Families for VEGFB(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P49765
ProtoNet protein and cluster: P49765 2 Blocks protein families: IPB000072 Platelet-derived growth factor (PDGF) IPB002400 Growth factor cystine knot superfamily signature
UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765Similarity: Belongs to the PDGF/VEGF growth factor family | Gene Function for VEGFB
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (VEGFB) | |  | Millipore RNAi Products for the Analysis of VEGFB Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (VEGFB) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003377
Applied Biosystems Silencer® siRNAs for VEGFB
Sigma-Aldrich siRNA and siRNA Panels for VEGFB  Sigma-Aldrich shRNA Panels and shRNA for VEGFB  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003377                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003377                                  untagged cDNA clone in CMV expression vector: NM_003377 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003377
UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysisGenatlas biochemistry entry for VEGFB:vascular endothelial growth factor B,with two alternatively spliced forms differing at their C terminal,universally expressed,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Vegfb):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for VEGFB
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for VEGFB (Your Favorite Gene powered by Ingenuity) (see all 10
) 
Gene Network CentralTM Interacting Genes and Proteins Network for VEGFB 
5/22 Interacting proteins for VEGFB (ENSP000003111273) via UniProtKB, MINT, and/or STRING (see all 22
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VEGFB(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for VEGFB |
 | Sigma-Aldrich Small Molecules for VEGFB: Inhibitor |
Browse Tocris compounds for VEGFB 2 Novoseek chemical compound relationships for VEGFB gene
About this table
|
Transcripts for VEGFB(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (VEGFB) | |  | Millipore RNAi Products for the Analysis of VEGFB Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (VEGFB) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003377
Sigma-Aldrich siRNA and siRNA Panels for VEGFB  Sigma-Aldrich shRNA Panels and shRNA for VEGFB  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003377 REFSEQ mRNAs for VEGFB gene: NM_003377.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003377               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003377                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003377                                  untagged cDNA clone in CMV expression vector: NM_003377  Additional cDNA sequence: BC008818.2 CR602359.1 U43368.1 U43369.1 U48801.1 U52819.1 5 DOTS entries: DT.456113 DT.92325533 DT.97845793 DT.95139285 DT.91745181 24/174 AceView cDNA sequences (see all 174
):BM694361 AA742966 BI962562 BU736807 U43369 CB155272 BG031449 AA746258 U43368 BM701452 BC008818 BM704880 R29477 T08411 AA400486 NM_003377 CR602359 AI687256 BQ009854 BM705235 BQ011717 AA419103 AI300509 CD671140
highest scoring ESTs for VEGFB:U43368 U48801 AA040199 AA040843 AA082818 AA182397 AA304346 AA310070 AA352350 AA400486 Unigene Cluster for VEGFB: Vascular endothelial growth factor B Hs.78781 [show with all ESTs]Unigene Representative Sequence: BM546651
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFB
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VEGFB
1 Ensembl transcript including schematic representation: ENST00000309422
|
Expression for VEGFB
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VEGFB expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VEGFB
1 / 2 / 3 4 probe-sets matching VEGFB gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTTTTCAGA
SOURCE GeneReport for Unigene cluster: Hs.78781
Expression variation in blood from EXPOLDB for VEGFB UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765Tissue specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas |
Orthologs for VEGFB
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VEGFB gene from 1 species
About this table Species with no ortholog for VEGFB
ENSEMBL Gene Tree for VEGFB | Paralogs for VEGFB(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VEGFB gene
- VEGFC2 PGF2 FIGF2 VEGFA2
|
SNPs/Variants for VEGFB(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VEGFB (up to first 250kb)
|
Disorders & Mutations for VEGFB
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601398
10/28 Novoseek disease relationships for VEGFB gene (see all 28
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neovascularization |
62.42 |
8 |
15032727 (1), 18930733 (1), 19369214 (1), 16407796 (1) (see all 5) |
| metastasis |
39.54 |
15 |
12866573 (4), 10873096 (2), 11241411 (2), 11505400 (1) (see all 8) |
| tumors |
39.22 |
37 |
9665470 (4), 15107801 (3), 18537151 (2), 10815914 (2) (see all 17) |
| hnscc |
27.72 |
1 |
11505400 (1) |
| cancer |
25.58 |
1 |
15664381 (1) |
| adenocarcinoma lung |
20.34 |
1 |
10873096 (1) |
| glioblastoma |
19.25 |
2 |
12622137 (2) |
| primary tumor |
19.03 |
2 |
10815914 (1), 15107801 (1) |
| carcinoma papillary |
19.00 |
1 |
11306510 (1) |
| pancreatic carcinoma |
16.87 |
1 |
15952180 (1) |
About this table
Human Genome Epidemiology Navigator: VEGFB (1 document)
|
Medical News for VEGFB(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VEGFB (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/140 PubMed articles for VEGFB gene (see all 140
):- Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (PubMed id 8637916)1, 2, 3, 4 Olofsson B.... Eriksson U. (1996)
- Cloning and characterization of a novel human gene related to vascular endothelial growth factor. (PubMed id 8919691)1, 2, 3, 4 Grimmond S....Weber G. (1996)
- Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. (PubMed id 16616187)1, 3, 4 Iyer S....Ravi Acharya K. (2006)
- Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. (PubMed id 8702615)1, 3, 4 Olofsson B....Eriksson U. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment. (PubMed id 18930733)1, 3 Leonard P....Acharya K.R. (2008)
- Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. (PubMed id 9751730)1, 3 Olofsson B....Eriksson U. (1998)
- Correlations of the expression of vascular endothelial growth factor B and its isoforms in hepatocellular carcinoma with clinico-pathological parameters. (PubMed id 18537151)1, 3 Kanda M....Nakao A. (2008)
- Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. (PubMed id 10409677)1, 3 Makinen T....Alitalo K. (1999)
- Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts. (PubMed id 15009103)1, 3 Trompezinski S....Viac J. (2004)
|
Search for VEGFB
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VEGFB
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VEGFB
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VEGFB(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| Licensable Technologies for VEGFB gene:
| Services for VEGFB(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VEGFB:

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| Antibodies & Assays for VEGFB  (VEGF-B) |
| | | | Search Tocris compounds for VEGFB |
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