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VEGFB Gene

protein-coding   GIFtS: 62
GCID: GC11P064002

Vascular Endothelial Growth Factor B


(Previous symbol: VRF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vascular Endothelial Growth Factor B1 2
VRF1 2 3 5
VEGF-Related Factor2 3
VEGFL2
VEGF-B3

External Ids:    HGNC: 126811   Entrez Gene: 74232   Ensembl: ENSG000001735117   OMIM: 6013985   UniProtKB: P497653   
ORGUL members:         

Export aliases for VEGFB gene to outside databases

Previous GC identifers: GC11P066518 GC11P065683 GC11P064253 GC11P063777 GC11P063758 GC11P060330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VEGFB Gene:
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor)
family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell
physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1
(neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes
and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced
transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Sep 2011)

GeneCards Summary for VEGFB Gene:
VEGFB (vascular endothelial growth factor B) is a protein-coding gene. Diseases associated with VEGFB include intracranial arteriovenous malformation, and primary effusion lymphoma. GO annotations related to this gene include growth factor activity and protein homodimerization activity. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to
neuropilin-1 of VEGF-B186 is regulated by proteolysis

Gene Wiki entry for VEGFB (Vascular endothelial growth factor B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the VEGFB gene promoter:
         Max1   ER-alpha   RFX1   Pax-5   Pax-2   Pax-2a   CP2   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVEGFB promoter sequence
   Search Chromatin IP Primers for VEGFB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VEGFB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

VEGFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064002:  view genomic region     (about GC identifiers)

Start:
64,002,010 bp from pter      End:
64,006,259 bp from pter
Size:
4,250 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765 (See protein sequence)
Recommended Name: Vascular endothelial growth factor B precursor  
Size: 207 amino acids; 21602 Da
Subunit: Homodimer; disulfide-linked. Can also form heterodimer with VEGF
3 PDB 3D structures from and Proteopedia for VEGFB:
2C7W (3D)        2VWE (3D)        2XAC (3D)    
Secondary accessions: Q16528
Alternative splicing: 2 isoforms:  P49765-1   P49765-2   

Explore the universe of human proteins at neXtProt for VEGFB: NX_P49765

Explore proteomics data for VEGFB at MOPED

Post-translational modifications: 

  • VEGF-B186 is O-glycosylated (By similarity)1
  • Modification sites at neXtProt

  • See VEGFB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230662.1  NP_003368.1  

    ENSEMBL proteins: 
     ENSP00000311127   ENSP00000401550   ENSP00000442526  
    Reactome Protein details: P49765

    VEGFB Human Recombinant Protein Products:

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    Novus Biologicals VEGFB Proteins
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    Cloud-Clone Corp. Proteins for VEGFB

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    Cloud-Clone Corp. ELISAs for VEGFB
    Cloud-Clone Corp. CLIAs for VEGFB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PDGF/VEGF_dom

    Graphical View of Domain Structure for InterPro Entry P49765

    ProtoNet protein and cluster: P49765

    2 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
    Similarity: Belongs to the PDGF/VEGF growth factor family


    VEGFB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFB_HUMAN, P49765
    Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to
    neuropilin-1 of VEGF-B186 is regulated by proteolysis

         Genatlas biochemistry entry for VEGFB:
    vascular endothelial growth factor B,with two alternatively spliced forms differing at their C
    terminal,universally expressed,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11122379
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
    GO:0042056chemoattractant activity IDA19275959
    GO:0042803protein homodimerization activity IEA--
         
    VEGFB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for VEGFB:
     Altered focal adhesion (FA) or  Decreased G3BP1 protein expres  Weaker migration 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vegfb):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system  vision/eye 

    VEGFB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vegfbtm1Ueks for VEGFB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VEGFB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VEGFB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VEGFB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VEGFB

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VEGFB (see all 9):
    hsa-miR-3934 hsa-miR-1231 hsa-miR-657 hsa-miR-597 hsa-miR-1205 hsa-miR-646 hsa-miR-1180 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidVEGFB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VEGFB
    Predesigned siRNA for gene silencing in human, mouse, rat VEGFB

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for VEGFB
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    GenScript: all cDNA clones in your preferred vector: VEGFB (NM_003377)
    Sino Biological Human cDNA Clone for VEGFB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VEGFB_HUMAN, P49765: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix
    unless released by heparin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12881472
    GO:0005622intracellular ----
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--

    VEGFB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VEGFB About   (see all 29)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VEGFB (see all 60)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for VEGFB
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for VEGFB
        Development VEGF-family signaling

    4 BioSystems Pathways for VEGFB
        Focal Adhesion
    Heart Development
    VEGFR1 specific signals
    Signaling events mediated by VEGFR1 and VEGFR2

    1 Sino Biological Pathway for VEGFB
        VEGF Signaling

    3 Reactome Pathways for VEGFB
        VEGF ligand-receptor interactions
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation

    1 PharmGKB Pathway for VEGFB
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for VEGFB) (see all 6):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion


    VEGFB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFB (see all 6): 
              mTOR Signaling in human mouse rat
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VEGFB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for VEGFB (P497653 ENSP000003111274) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNXBP221053, ENSP000003643964I2D: score=1 STRING: ENSP00000364396
    ENSG00000229353P221053I2D: score=1 
    ENSG00000236236P221053I2D: score=1 
    FLT1P179483, ENSP000002823974I2D: score=3 STRING: ENSP00000282397
    NRP1O147863, ENSP000002653714I2D: score=2 STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation IDA11122379
    GO:0002576platelet degranulation TAS--
    GO:0006493protein O-linked glycosylation IEA--
    GO:0007507heart development ----

    VEGFB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VEGFB

    4 Novoseek inferred chemical compound relationships for VEGFB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 87.3 128 9348202 (6), 9426398 (5), 9751730 (5), 11241411 (4) (see all 64)
    tyrosine 49.7 9 15032727 (1), 11306510 (1), 12888864 (1), 18794121 (1) (see all 8)
    heparin 1.16 2 12613545 (1), 17979153 (1)
    oxygen 0 1 10575000 (1)



    VEGFB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VEGFB gene (2 alternative transcripts): 
    NM_001243733.1  NM_003377.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309422(uc001nyx.3 uc001nyw.3) ENST00000426086 ENST00000543462
    ENST00000541681
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VEGFB (see all 9):
    hsa-miR-3934 hsa-miR-1231 hsa-miR-657 hsa-miR-597 hsa-miR-1205 hsa-miR-646 hsa-miR-1180 hsa-miR-374a*
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      QuantiTect SYBR Green Assays in human, mouse, rat VEGFB
      QuantiFast Probe-based Assays in human, mouse, rat VEGFB

    Selected AceView cDNA sequences (see all 174):

    BM705235 AA400532 U43368 BQ009854 BM694361 BM704880 CB155272 AI300509 
    AA419103 T08411 BG031449 CD671140 U48801 U43369 BI962562 BC008818 
    AA400486 AA746258 R29477 AW952041 AA742966 NM_003377 BM701452 CR602359 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                      
    SP2:                                -                     


    ECgene alternative splicing isoforms for VEGFB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VEGFB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTTCAGA
    VEGFB Expression
    About this image

    VEGFB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VEGFB Protein Expression

    UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
    Tissue specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and
    pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFB (see all 6): 
              mTOR Signaling in human mouse rat
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VEGFB
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    QuantiFast Probe-based Assays in human, mouse, rat VEGFB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFB gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vegfb1 , 5 vascular endothelial growth factor B1, 5 89.96(n)1
    87.95(a)1
      19 (5.12 cM)5
    223401  NM_001185164.11  NP_001172093.11 
     69824735 
    zebrafish
    (Danio rerio)
    Actinopterygii vegfbb6
    BX511266.16
    Uncharacterized protein
    34(a)
    20(a)
    1 ↔ many
    1 ↔ many
    21(25926276-25929208) ENSDARG00000092480
    14(8475537-8537912) ENSDARG00000090997


    ENSEMBL Gene Tree for VEGFB (if available)
    TreeFam Gene Tree for VEGFB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for VEGFB gene
    PGF2  VEGFA2  
    2 SIMAP similar genes for VEGFB using alignment to 4 protein entries:     VEGFB_HUMAN (see all proteins):
    VEGFA    PGF

    VEGFB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for VEGFB    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680467491,2
    C,F--64004557(+) TCTCAG/AAGAGA 2 -- int13Minor allele frequency- A:0.33WA NA 6
    rs676698821,2
    C--64004558(+) CTCAA-/AGAGAGA
    GAGAGAGAG
    AGAGA
    2 -- int10--------
    rs671105591,2
    C--64004580(+) GAGAG-/AGAGAGA
    GAGAGAGAG
    TAGGA
    2 -- int11Minor allele frequency- AGAGAGAGAGAGAGAG:0.00NA 2
    rs105854321,2
    ----64004585(+) agaga-/GAgagag 2 -- int1 trp30--------
    rs590943041,2
    ----64004557(+) TCTCA-/AAGA  
      GAGAGA
    GAGAG
    2 -- int10--------
    rs105854311,2
    ----64004557(+) tctca-/AAGA  
            
    gagag
    2 -- int10--------
    rs785300881,2
    ----64004214(+) AAAAAG/AAAGAG 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1127153861,2
    ----64004558(+) CTCAAAGAGA   
       GAG
    /-
    AGAGA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs674659141,2
    ----64004586(+) GAGAG-/AGAG  
      AGAGAG
    TAGGA
    2 -- int10--------
    rs766846661,2
    ----64004199(+) AAAAAC/AAAAAA 2 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for VEGFB (64002010 - 64006259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VEGFB (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv992196CNV Deletion20482838
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    nsv897683CNV Loss21882294
    nsv897674CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1167n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601398    OMIM disorders: --

    Selected diseases for VEGFB (see all 50):    
    About MalaCards
    intracranial arteriovenous malformation    primary effusion lymphoma    cleidocranial dysplasia    brain cancer
    arteriovenous malformation    lymphedema    endotheliitis    angiosarcoma
    rabies    age related macular degeneration    vascular disease    lung adenocarcinoma
    oral squamous cell carcinoma    ependymoma    leiomyoma    atherosclerosis
    choroiditis    encephalomyelitis    colorectal cancer    medulloblastoma


    VEGFB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for VEGFB gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 63.4 9 15032727 (1), 18930733 (1), 19369214 (1), 19684473 (1) (see all 6)
    metastasis 41.8 15 12866573 (4), 10873096 (2), 11241411 (2), 11505400 (1) (see all 8)
    tumors 41.7 37 9665470 (4), 15107801 (3), 18537151 (2), 10815914 (2) (see all 17)
    cancer 29.8 1 15664381 (1)
    glioblastoma 25.4 2 12622137 (2)
    hnscc 24.8 1 11505400 (1)
    adenocarcinoma lung 17.6 1 10873096 (1)
    carcinoma papillary 17.2 1 11306510 (1)
    primary tumor 16.8 2 10815914 (1), 15107801 (1)
    pancreatic carcinoma 15 1 15952180 (1)

    Genetic Association Database (GAD): VEGFB
    Human Genome Epidemiology (HuGE) Navigator: VEGFB (9 documents)

    Export disorders for VEGFB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VEGFB gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with VEGFB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (PubMed id 8637916)1, 2, 3, 9 Olofsson B.... Eriksson U. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. (PubMed id 8919691)1, 2, 3, 9 Grimmond S.... Weber G. (Genome Res. 1996)
    3. Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. (PubMed id 16616187)1, 2, 9 Iyer S.... Ravi Acharya K. (J. Mol. Biol. 2006)
    4. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. (PubMed id 8702615)1, 2, 9 Olofsson B....Eriksson U. (J. Biol. Chem. 1996)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis. (PubMed id 20308035)1, 4 Van Hee V.C....Kaufman J.D. (Environ. Health Perspect. 2010)
    7. Allelic variations in angiogenic pathway genes are associated with preeclampsia. (PubMed id 20223440)1, 4 Srinivas S.K....Elovitz M.A. (Am. J. Obstet. Gynecol. 2010)
    8. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    9. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    10. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7423 HGNC: 12681 AceView: VEGFB Ensembl:ENSG00000173511 euGenes: HUgn7423
    ECgene: VEGFB Kegg: 7423 H-InvDB: VEGFB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VEGFB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VEGFB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VEGFB gene:
    Search GeneIP for patents involving VEGFB

    Licensable Technologies for VEGFB gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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