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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VEGFB Gene

protein-coding   GIFtS: 64
GCID: GC11P064002

vascular endothelial growth factor B


(Previous symbol: VRF)
 Explore 55 diseases affiliated with
VEGFB via our new
 Human Malady Compendium 
Biological research products
for VEGFB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Vascular Endothelial Growth Factor B1 2
VRF1 2 3 5
VEGFL1 2
VEGF-Related Factor2 3
VEGF-B3

External Ids:    HGNC: 126811   Entrez Gene: 74232   Ensembl: ENSG000001735117   OMIM: 6013985   UniProtKB: P497653   

Export aliases for VEGFB gene to outside databases

Previous GC identifers: GC11P066518 GC11P065683 GC11P064253 GC11P063777 GC11P063758 GC11P060330


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VEGFB:
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor)
family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell
physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1
(neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and
the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to
neuropilin-1 of VEGF-B186 is regulated by proteolysis

Gene Wiki entry for VEGFB (Vascular endothelial growth factor B)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VEGFB gene promoter:
         Max1   ER-alpha   RFX1   Pax-5   Pax-2   Pax-2a   CP2   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVEGFB promoter sequence
   Search SABiosciences Chromatin IP Primers for VEGFB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEGFB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

VEGFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064002:  view genomic region     (about GC identifiers)

Start:
64,002,010 bp from pter      End:
64,006,259 bp from pter
Size:
4,250 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765 (See protein sequence)
Recommended Name: Vascular endothelial growth factor B precursor  
Size: 207 amino acids; 21602 Da
Subunit: Homodimer; disulfide-linked. Can also form heterodimer with VEGF
Subcellular location: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless
released by heparin
3 PDB 3D structures from and Proteopedia for VEGFB:
2C7W (3D)        2VWE (3D)        2XAC (3D)    
Secondary accessions: Q16528
Alternative splicing: 2 isoforms:  P49765-1   P49765-2   

Explore the universe of human proteins at neXtProt for VEGFB: NX_P49765

Post-translational modifications:

  • VEGF-B186 is O-glycosylated (By similarity)1
  • View neXtProt modification sites for NX_P49765

  • VEGFB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230662.1  NP_003368.1  

    ENSEMBL proteins: 
     ENSP00000311127   ENSP00000401550   ENSP00000442526  
    Reactome Protein details: P49765
    Human Recombinant Protein Products: 
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    Uscn Proteins for VEGFB

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8637916
    GO:0005622intracellular ----
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--


    VEGFB for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VEGFB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000072 PD_growth_factor
     IPR023581 PD_growth_factor_CS

    Graphical View of Domain Structure for InterPro Entry P49765

    ProtoNet protein and cluster: P49765

    2 Blocks protein families:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
    Similarity: Belongs to the PDGF/VEGF growth factor family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
    Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to
    neuropilin-1 of VEGF-B186 is regulated by proteolysis

         Genatlas biochemistry entry for VEGFB:
    vascular endothelial growth factor B,with two alternatively spliced forms differing at their C terminal,universally
    expressed,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL

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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19483306
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
    GO:0042056chemoattractant activity IDA19275959
    GO:0042803protein homodimerization activity IEA--


    VEGFB for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for VEGFB:
     Altered focal adhesion (FA) or  Decreased G3BP1 protein expres  Weaker migration 

    Animal Models:
         Mouse knock-out Vegfbtm1Ueks for VEGFB
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vegfb):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system  vision/eye 

    VEGFB for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/32 super-pathways (see all 32About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    Apoptotic Pathways in Synovial Fibroblasts1.00
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    Mitochondrial Apoptosis0.73
    Rac1 Pathway0.58
    Telomerase Components in Cell Signaling0.72
    Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    GPCR Pathway1.00
    Estrogen Pathway0.55
    Ras Pathway0.62
    Pancreatic Adenocarcinoma0.55
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.53
    NFAT in Immune Response0.58
    P2Y Receptor Signaling0.38
    3TGF-Beta Pathway
    TGF-Beta Pathway1.00
    JNK Pathway0.50
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.29
    4Rho Family GTPases
    Rho Family GTPases1.00
    MAPK Signaling0.51
    ERK Signaling0.61
    ILK Signaling0.45
    Molecular Mechanisms of Cancer0.51
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency1.00
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for VEGFB
        Development VEGF-family signaling

    5/60 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VEGFB (see all 60)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for VEGFB
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for VEGFB
        Development VEGF-family signaling

    4 BioSystems Pathways for VEGFB 
        Focal Adhesion
    Heart Development
    VEGFR1 specific signals
    Signaling events mediated by VEGFR1 and VEGFR2

    5/8        Reactome Pathways for VEGFB (see all 8)
        VEGF ligand-receptor interactions
    Signaling by VEGF
    Hemostasis
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation

    1 PharmGKB Pathway for VEGFB
        VEGF Signaling Pathway

    5/8         Kegg Pathways  (Kegg details for VEGFB) (see all 8):
        Cytokine-cytokine receptor interaction
    mTOR signaling pathway
    Focal adhesion
    Pathways in cancer
    Renal cell carcinoma


    VEGFB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VEGFB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for VEGFB (P497653 ENSP000003111274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT1P179483, ENSP000002823974I2D: score=3 STRING: ENSP00000282397
    TNXBP221053, ENSP000003643964I2D: score=1 STRING: ENSP00000364396
    NRP1O147863, ENSP000002653714I2D: score=2 STRING: ENSP00000265371
    VEGFAP156923, ENSP000003611254I2D: score=2 STRING: ENSP00000361125
    ITGB1P055563I2D: score=1 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation IDA8637916
    GO:0002576platelet degranulation TAS--
    GO:0006493protein O-linked glycosylation IEA--
    GO:0007507heart development ----


    VEGFB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VEGFB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VEGFB
    4 Novoseek chemical compound relationships for VEGFB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 87.3 128 9348202 (6), 9426398 (5), 9751730 (5), 11241411 (4) (see all 64)
    tyrosine 49.7 9 15032727 (1), 11306510 (1), 12888864 (1), 18794121 (1) (see all 8)
    heparin 1.16 2 12613545 (1), 17979153 (1)
    oxygen 0 1 10575000 (1)

    Search CenterWatch for drugs/clinical trials and news about VEGFB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VEGFB gene (2 alternative transcripts): 
    NM_001243733.1  NM_003377.4  

    Unigene Cluster for VEGFB:

    Vascular endothelial growth factor B
    Hs.732095  [show with all ESTs]
    Unigene Representative Sequence: NM_003377
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309422(uc001nyx.3 uc001nyw.3) ENST00000426086 ENST00000543462
    ENST00000541681

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    Additional cDNA sequence: 

    BC008818.2 U43368.1 U43369.1 U48801.1 U52819.1 

    5 DOTS entries:

    DT.456113  DT.92325533  DT.97845793  DT.95139285  DT.91745181 

    24/174 AceView cDNA sequences (see all 174):

    CD671140 AW952041 BM694361 NM_003377 BQ009854 CB155272 AA400486 R29477 
    BC008818 T08411 AA419103 BG031449 AI687256 BM701452 BU736807 BQ011717 
    CR602359 BM704880 U43369 BI962562 BM705235 AA742966 U48801 AA400532 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                      
    SP2:                                -                     


    ECgene alternative splicing isoforms for VEGFB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VEGFB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTTTCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See VEGFB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VEGFB

    SOURCE GeneReport for Unigene cluster: Hs.732095

    UniProtKB/Swiss-Prot: VEGFB_HUMAN, P49765
    Tissue specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including VEGFB (see all 6): 
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              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat

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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for VEGFB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFB gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii BX511266.16
    --
    22(a)
    1 ↔ 1
    14(8475537-8537912)


    ENSEMBL Gene Tree for VEGFB (if available)
    TreeFam Gene Tree for VEGFB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VEGFB gene
    VEGFC2  PGF2  FIGF2  VEGFA2  
    2 SIMAP similar genes for VEGFB using alignment to 4 protein entries:     VEGFB_HUMAN (see all proteins):
    VEGFA    PGF

    VEGFB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 NCBI SNPs in VEGFB are shown (see all 110    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872436851,2
    --64002495(+) TCTCGG/TGGGCC 2 -- int10--------
    rs1481486881,2
    --64002520(+) CCTGGA/GAGGTG 2 -- int10--------
    rs1419405171,2
    --64002787(+) TAGAGC/TAGTGG 2 -- int10--------
    rs2005641261,2
    C--64002937(+) CCCTGT/CCTCCC 4 /A /V mis11Minor allele frequency- C:0.00EU 1317
    rs1816319151,2
    --64003176(+) AGAGTG/TGGGAG 2 -- int10--------
    rs1867116321,2
    C,--64003261(+) GGACTC/TAACCC 2 -- int10--------
    rs1507576141,2
    --64003314(+) CTCGCG/TCTACC 4 A S mis10--------
    rs617612661,2
    C,F,,--64003328(+) CAGCCC/TCGGGA 4 P syn14Minor allele frequency- T:0.00NS NA EU 5927
    rs2003610631,2
    --64003352(+) TTGACC/TGTGGA 4 T syn10--------
    rs1390942261,2
    C,--64003410(+) TGCAGC/TGCTGT 4 R C mis10--------

    HapMap Linkage Disequilibrium report for VEGFB (64002010 - 64006259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for VEGFB
         1 CNV: 71339

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VEGFB for disorders           About GeneDecksing

    OMIM gene information: 601398    OMIM disorders: --

    20/55 diseases for VEGFB (see all 55):    About MalaCards
    intracranial arteriovenous malformation    age related macular degeneration    arteriovenous malformation    focal cortical dysplasia
    cleidocranial dysplasia    macular degeneration    primary effusion lymphoma    oral squamous cell carcinoma
    squamous cell carcinoma    lymphedema    carcinoma    endometrial cancer
    renal cell carcinoma    angiosarcoma    pulmonary hypertension    rheumatoid arthritis
    pancreatic carcinoma    multiple sclerosis    breast carcinoma    colorectal cancer

    10/28 Novoseek disease relationships for VEGFB gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 63.4 9 15032727 (1), 18930733 (1), 19369214 (1), 19684473 (1) (see all 6)
    metastasis 41.8 15 12866573 (4), 10873096 (2), 11241411 (2), 11505400 (1) (see all 8)
    tumors 41.7 37 9665470 (4), 15107801 (3), 18537151 (2), 10815914 (2) (see all 17)
    cancer 29.8 1 15664381 (1)
    glioblastoma 25.4 2 12622137 (2)
    hnscc 24.8 1 11505400 (1)
    adenocarcinoma lung 17.6 1 10873096 (1)
    carcinoma papillary 17.2 1 11306510 (1)
    primary tumor 16.8 2 10815914 (1), 15107801 (1)
    pancreatic carcinoma 15 1 15952180 (1)

    Human Genome Epidemiology (HuGE) Navigator: VEGFB (9 documents)

    Export disorders for VEGFB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VEGFB gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with VEGFB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (PubMed id 8637916)1, 2, 3, 9 Olofsson B.... Eriksson U. (1996)
    2. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. (PubMed id 8919691)1, 2, 3, 9 Grimmond S.... Weber G. (1996)
    3. Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. (PubMed id 16616187)1, 2, 9 Iyer S.... Ravi Acharya K. (2006)
    4. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. (PubMed id 8702615)1, 2, 9 Olofsson B....Eriksson U. (1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment. (PubMed id 18930733)1, 9 Leonard P....Acharya K.R. (2008)
    7. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. (PubMed id 9751730)1, 9 Olofsson B....Eriksson U. (1998)
    8. Correlations of the expression of vascular endothelial growth factor B and its isoforms in hepatocellular carcinoma with clinico-pathological parameters. (PubMed id 18537151)1, 9 Kanda M....Nakao A. (2008)
    9. Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. (PubMed id 10409677)1, 9 Makinen T....Alitalo K. (1999)
    10. Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies. (PubMed id 12366396)1, 9 Scotney P.D....Nash A.D. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7423 HGNC: 12681 AceView: VEGFB Ensembl:ENSG00000173511 euGenes: HUgn7423
    ECgene: VEGFB Kegg: 7423 H-InvDB: VEGFB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VEGFB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VEGFB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VEGFB gene:
    Search GeneIP for patents involving VEGFB

    Licensable Technologies for VEGFB gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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