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Aliases for VEGFA Gene

Aliases for VEGFA Gene

  • Vascular Endothelial Growth Factor A 2 3
  • VEGF 3 4 6
  • Vascular Permeability Factor 3 4
  • MVCD1 3 6
  • VPF 3 4
  • Vascular Endothelial Growth Factor 2
  • VEGF-A 4

External Ids for VEGFA Gene

Previous HGNC Symbols for VEGFA Gene

  • VEGF

Previous GeneCards Identifiers for VEGFA Gene

  • GC06P043846
  • GC06P043458

Summaries for VEGFA Gene

Entrez Gene Summary for VEGFA Gene

  • This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for VEGFA Gene

VEGFA (Vascular Endothelial Growth Factor A) is a Protein Coding gene. Diseases associated with VEGFA include microvascular complications of diabetes 1 and poems syndrome. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot for VEGFA Gene

  • Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Gene Wiki entry for VEGFA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFA Gene

Genomics for VEGFA Gene

Regulatory Elements for VEGFA Gene

Genomic Location for VEGFA Gene

Start:
43,770,184 bp from pter
End:
43,786,487 bp from pter
Size:
16,304 bases
Orientation:
Plus strand

Genomic View for VEGFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VEGFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFA Gene

Proteins for VEGFA Gene

  • Protein details for VEGFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15692-VEGFA_HUMAN
    Recommended name:
    Vascular endothelial growth factor A
    Protein Accession:
    P15692
    Secondary Accessions:
    • B5BU86
    • H0Y2S8
    • H0Y407
    • H0Y414
    • H0Y462
    • H0Y8N2
    • H3BLW7
    • O60720
    • O75875
    • Q074Z4
    • Q16889
    • Q5UB46
    • Q6P0P5
    • Q96KJ0
    • Q96L82
    • Q96NW5
    • Q9H1W8
    • Q9H1W9
    • Q9UH58
    • Q9UL23

    Protein attributes for VEGFA Gene

    Size:
    232 amino acids
    Molecular mass:
    27042 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).
    SequenceCaution:
    • Sequence=AAC63102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC63143.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VEGFA Gene

neXtProt entry for VEGFA Gene

Proteomics data for VEGFA Gene at MOPED

Post-translational modifications for VEGFA Gene

  • Glycosylation at Asn101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VEGFA Gene

Domains for VEGFA Gene

Suggested Antigen Peptide Sequences for VEGFA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15692

UniProtKB/Swiss-Prot:

VEGFA_HUMAN :
  • P15692
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFA: view

No data available for Gene Families for VEGFA Gene

Function for VEGFA Gene

Molecular function for VEGFA Gene

UniProtKB/Swiss-Prot Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
UniProtKB/Swiss-Prot Induction: By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.

Gene Ontology (GO) - Molecular Function for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IDA 14570917
GO:0005102 receptor binding --
GO:0005125 cytokine activity ISS --
GO:0005161 platelet-derived growth factor receptor binding IPI 17470632
GO:0005172 vascular endothelial growth factor receptor binding IPI 10471394
genes like me logo Genes that share ontologies with VEGFA: view
genes like me logo Genes that share phenotypes with VEGFA: view

Animal Models for VEGFA Gene

MGI Knock Outs for VEGFA:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VEGFA Gene

Localization for VEGFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFA Gene

Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEGFA Gene COMPARTMENTS Subcellular localization image for VEGFA gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 14570917
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm IDA 17082651
GO:0009986 cell surface IDA 17470632
genes like me logo Genes that share ontologies with VEGFA: view

Pathways for VEGFA Gene

genes like me logo Genes that share pathways with VEGFA: view

Gene Ontology (GO) - Biological Process for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18093989
GO:0001525 angiogenesis IDA 11427521
GO:0001541 ovarian follicle development ISS --
GO:0001568 blood vessel development --
GO:0001569 patterning of blood vessels ISS --
genes like me logo Genes that share ontologies with VEGFA: view

Compounds for VEGFA Gene

(3) HMDB Compounds for VEGFA Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5
Heparin
  • Arteven
9005-49-6
Simvastatin
  • (+)-Simvastatin
79902-63-9

(10) Drugbank Compounds for VEGFA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aflibercept
  • AVE 0005
862111-32-8 target binder
Bevacizumab
  • antiVEGF
216974-75-3 target
Carvedilol
72956-09-3 target other
Dalteparin
  • Daltepariininatrium
9041-08-1 target inhibitor
Gliclazide
  • 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea
21187-98-4 target other/unknown

(106) Novoseek inferred chemical compound relationships for VEGFA Gene

Compound -log(P) Hits PubMed IDs
vegf 99.5 1247
su5416 84.2 67
pegaptanib 83.9 65
matrigel 83.7 108
ranibizumab 82.8 89

(9) PharmGKB related drug/compound annotations for VEGFA Gene

genes like me logo Genes that share compounds with VEGFA: view

Transcripts for VEGFA Gene

Unigene Clusters for VEGFA Gene

Vascular endothelial growth factor A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for VEGFA Gene

GeneLoc Exon Structure for
VEGFA
ECgene alternative splicing isoforms for
VEGFA

Expression for VEGFA Gene

mRNA expression in normal human tissues for VEGFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VEGFA Gene

This gene is overexpressed in Thyroid (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VEGFA Gene

SOURCE GeneReport for Unigene cluster for VEGFA Gene Hs.73793

mRNA Expression by UniProt/SwissProt for VEGFA Gene

P15692-VEGFA_HUMAN
Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
genes like me logo Genes that share expressions with VEGFA: view

Orthologs for VEGFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VEGFA 35
  • 95.26 (n)
  • 94.74 (a)
VEGFA 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEGFA 35
  • 94.39 (n)
  • 95.79 (a)
VEGFA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vegfa 35
  • 88.52 (n)
  • 83.93 (a)
Vegfa 16
Vegfa 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VEGFA 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VEGFA 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vegfa 35
  • 88.89 (n)
  • 84.22 (a)
chicken
(Gallus gallus)
Aves VEGFA 35
  • 78.29 (n)
  • 74.88 (a)
VEGFA 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEGFA 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vegf-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3662 35
zebrafish
(Danio rerio)
Actinopterygii vegf 35
vegfaa 36
  • 57 (a)
OneToMany
vegfab 35
  • 57.26 (n)
  • 50.99 (a)
vegfab 36
  • 44 (a)
OneToMany
Species with no ortholog for VEGFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFA Gene

ENSEMBL:
Gene Tree for VEGFA (if available)
TreeFam:
Gene Tree for VEGFA (if available)

Paralogs for VEGFA Gene

Paralogs for VEGFA Gene

genes like me logo Genes that share paralogs with VEGFA: view

Variants for VEGFA Gene

Sequence variations from dbSNP and Humsavar for VEGFA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10434 -- 43,785,475(+) AGGAG(A/G)CCACT utr-variant-3-prime
rs25648 -- 43,771,240(+) GCCTC(C/T)GAAAC reference, synonymous-codon, utr-variant-5-prime, upstream-variant-2KB
rs699947 other 43,768,652(+) TGGCA(A/C)GATCT upstream-variant-2KB
rs715843 -- 43,784,487(-) CCTGG(C/T)GATGA intron-variant
rs735286 -- 43,776,884(-) AGGAG(A/G)CTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFA Gene

Variant ID Type Subtype PubMed ID
nsv885848 CNV Loss 21882294
nsv823682 CNV Gain 20364138
nsv885849 CNV Gain 21882294
nsv885850 CNV Loss 21882294

Relevant External Links for VEGFA Gene

HapMap Linkage Disequilibrium report
VEGFA
Human Gene Mutation Database (HGMD)
VEGFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFA Gene

Disorders for VEGFA Gene

(1) OMIM Diseases for VEGFA Gene (192240)

UniProtKB/Swiss-Prot

VEGFA_HUMAN
  • Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for VEGFA Gene

Disease -log(P) Hits PubMed IDs
neovascularization 92.9 207
tumors 88.1 573
metastasis 83.9 368
cancer 80.7 322
proliferative diabetic retinopathy 80.2 133

Relevant External Links for VEGFA

Genetic Association Database (GAD)
VEGFA
Human Genome Epidemiology (HuGE) Navigator
VEGFA
genes like me logo Genes that share disorders with VEGFA: view

Publications for VEGFA Gene

  1. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. (PMID: 11978667) Awata T. … Katayama S. (Diabetes 2002) 3 4 23 48
  2. Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for prostate cancer. (PMID: 12893367) Lin C.C. … Chen W.C. (Urology 2003) 3 23 48
  3. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. (PMID: 14988276) Ray D. … Brenchley P. (Diabetes 2004) 3 23 48
  4. Vascular endothelial growth factor gene polymorphisms and pre-eclampsia. (PMID: 14997002) Papazoglou D. … Maltezos E. (Mol. Hum. Reprod. 2004) 3 23 48
  5. Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients. (PMID: 15086939) Szeto C.C. … Li P.K. (Kidney Int. 2004) 3 23 48

Products for VEGFA Gene

  • Addgene plasmids for VEGFA

Sources for VEGFA Gene

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