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VEGFA Gene

protein-coding   GIFtS: 70
GCID: GC06P043737

Vascular Endothelial Growth Factor A

(Previous name: vascular endothelial growth factor)
(Previous symbol: VEGF)
  See VEGFA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vascular Endothelial Growth Factor A1 2     MVCD12 5
VEGF1 2 3 5     Vascular Endothelial Growth Factor1
Vascular Permeability Factor2 3     VEGF-A3
VPF2 3     

External Ids:    HGNC: 126801   Entrez Gene: 74222   Ensembl: ENSG000001127157   OMIM: 1922405   UniProtKB: P156923   

Export aliases for VEGFA gene to outside databases

Previous GC identifers: GC06P043846 GC06P043458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VEGFA Gene:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a
disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells
and has various effects, including mediating increased vascular permeability, inducing angiogenesis,
vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels
of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been
associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript
variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also
evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG,
leading to additional isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for VEGFA Gene:
VEGFA (vascular endothelial growth factor A) is a protein-coding gene. Diseases associated with VEGFA include diabetic retinopathy, and poems syndrome. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial
cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms
VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does
not activate angiogenesis and inhibits tumor growth

Gene Wiki entry for VEGFA (Vascular endothelial growth factor A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VEGFA gene promoter:
         PPAR-alpha   PPAR-gamma1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): VEGFA promoter sequence
   Search Chromatin IP Primers for VEGFA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VEGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

VEGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043737:  view genomic region     (about GC identifiers)

Start:
43,737,921 bp from pter      End:
43,754,224 bp from pter
Size:
16,304 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692 (See protein sequence)
Recommended Name: Vascular endothelial growth factor A precursor  
Size: 232 amino acids; 27042 Da
Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity)
Sequence caution: Sequence=AAC63102.1; Type=Erroneous initiation; Sequence=AAC63143.1; Type=Miscellaneous
discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator.
The initiator methionine is coded by a non-canonical CTG leucine codon;
Selected PDB 3D structures from and Proteopedia for VEGFA (see all 28):
1BJ1 (3D)        1CZ8 (3D)        1FLT (3D)        1KAT (3D)        1KMX (3D)        1MJV (3D)    
Secondary accessions: B5BU86 O60720 O75875 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5
Q9H1W8 Q9H1W9 Q9UH58 Q9UL23
Alternative promoter usage, Alternative splicing, Alternative initiation: 13 isoforms:  P15692-1   P15692-2   P15692-3   P15692-4   P15692-5   P15692-6   P15692-8   P15692-9   
P15692-10   P15692-11   P15692-12   P15692-13   P15692-14   (Gene prediction based on EST data. Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon)

Explore the universe of human proteins at neXtProt for VEGFA: NX_P15692

Explore proteomics data for VEGFA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn101
  • Modification sites at PhosphoSitePlus

  • See VEGFA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (19 alternative transcripts): 
    NP_001020537.2  NP_001020538.2  NP_001020539.2  NP_001020540.2  NP_001020541.2  NP_001028928.1  NP_001165093.1  NP_001165094.1  
    NP_001165095.1  NP_001165096.1  NP_001165097.1  NP_001165098.1  NP_001165099.1  NP_001165100.1  NP_001165101.1  NP_001191313.1  
    NP_001191314.1  NP_001273973.1  NP_003367.4  

    ENSEMBL proteins: 
     ENSP00000361137   ENSP00000317598   ENSP00000388663   ENSP00000389864   ENSP00000361125  
     ENSP00000421561   ENSP00000388465   ENSP00000361134   ENSP00000361148   ENSP00000430594  
     ENSP00000428321   ENSP00000430479   ENSP00000429643   ENSP00000409911   ENSP00000430829  
     ENSP00000429008   ENSP00000430002   ENSP00000230480   ENSP00000429592  
    Reactome Protein details: P15692

    VEGFA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant VEGFA Protein
    R&D Systems Recombinant & Natural Proteins for VEGFA (VEGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VEGFA
    OriGene Protein Over-expression Lysate for VEGFA
    OriGene MassSpec for VEGFA
    OriGene Custom Protein Services for VEGFA
    GenScript Purified and Recombinant Proteins for VEGFA
    Novus Biologicals VEGFA Proteins
    Novus Biologicals VEGFA Lysates
    Sino Biological Recombinant Protein for VEGFA
    Sino Biological Cell Lysate for VEGFA
    ProSpec Recombinant Protein for VEGFA
    Cloud-Clone Corp. Proteins for VEGFA

     
    eBioscience Proteins for VEGFA: (see all 2
                        Human VEGF 121 Recombinant Protein 5 ug

    VEGFA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VEGFA
    R&D Systems Antibodies for VEGFA (VEGF)
    OriGene Antibodies for VEGFA
    OriGene Custom Antibody Services for VEGFA
    Novus Biologicals VEGFA Antibodies
    Abcam antibodies for VEGFA
    Cloud-Clone Corp. Antibodies for VEGFA
    ThermoFisher Antibody for VEGFA
    LSBio Antibodies in human, mouse, rat for VEGFA

    VEGFA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VEGFA
    R&D Systems Flow Cytometry Kits for VEGFA (VEGF)         (see all)
    GenScript Custom Assay Services for VEGFA
    Enzo Life Sciences assays for VEGFA
    Cloud-Clone Corp. ELISAs for VEGFA
    Cloud-Clone Corp. CLIAs for VEGFA
    eBioscience ELISAs for VEGFA: (see all 2
                        Human VEGF-A Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027928 VEGF_C
     IPR023581 PD_growth_factor_CS
     IPR000072 PDGF/VEGF_dom

    Graphical View of Domain Structure for InterPro Entry P15692

    ProtoNet protein and cluster: P15692

    1 Blocks protein domain: IPB000072 Platelet-derived growth factor (PDGF)

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Find genes that share domains with VEGFA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFA_HUMAN, P15692
    Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial
    cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
    Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms
    VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does
    not activate angiogenesis and inhibits tumor growth
    Induction: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and
    oncogenic mutations

         Summary: 

    During embryonic development, VEGFA as signaling molecule is secreted from the following cells:
          selected tissues (see all 3)      fully expand
    Bone: Terminal Chondrocytes (Vertebrae), Terminal Chondrocytes (Stylopod Growth Plate)      fully expand to see all 9 cells
    Neural Tube: Spinal Neural Tube Cells (Neural Tube)

    It affects the following cells:
          selected tissues (see all 5)      fully expand
    Bone: Terminal Chondrocytes (Stylopod Perichondrium), Endochondral Preosteoblasts (Autopod Perichondrium)      fully expand to see all 8 cells
    Neural Tube: Angioblasts (Perineural capillary Plexus)

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IDA14570917
    GO:0005125cytokine activity ISS--
    GO:0005161platelet-derived growth factor receptor binding IPI17470632
    GO:0005172vascular endothelial growth factor receptor binding IPI10471394
    GO:0005515protein binding IPI10543948
         
    Find genes that share ontologies with VEGFA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VEGFA:
     Decreased focal adhesion (FA)  

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Vegfa) (see all 25):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with VEGFA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VEGFA: Vegfatm1Gne Vegfatm1Dco Vegfatm2Pec Vegfatm1Pec

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VEGFA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VEGFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VEGFA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VEGFA

    miRNA
    Products:
        
    miRTarBase miRNAs that target VEGFA:
    hsa-mir-378a-3p (MIRT004277), hsa-mir-17-5p (MIRT004271), hsa-mir-21-5p (MIRT030717), hsa-mir-330-3p (MIRT004278), hsa-mir-101-3p (MIRT027248), hsa-mir-140-5p (MIRT003812), hsa-mir-29c-3p (MIRT020389), hsa-mir-20b-5p (MIRT004451), hsa-mir-20a-5p (MIRT004450), hsa-mir-372-3p (MIRT004461), hsa-mir-383-5p (MIRT004443), hsa-mir-200b-3p (MIRT006440), hsa-mir-302d-3p (MIRT000722), hsa-mir-16-5p (MIRT003890), hsa-mir-504-5p (MIRT004457), hsa-mir-361-5p (MIRT004447), hsa-mir-126-3p (MIRT003428), hsa-mir-93-5p (MIRT004055), hsa-mir-15a-5p (MIRT004275), hsa-mir-134-5p (MIRT003811), hsa-mir-106a-5p (MIRT004465), hsa-mir-373-3p (MIRT000721), hsa-mir-106b-5p (MIRT004466), hsa-mir-145-5p (MIRT006215), hsa-mir-195-5p (MIRT004273), hsa-mir-520g-3p (MIRT004276), hsa-mir-34a-5p (MIRT004513), hsa-mir-520h (MIRT004458), hsa-mir-335-5p (MIRT016911), hsa-mir-9-5p (MIRT021401), hsa-mir-107 (MIRT003814), hsa-mir-125a-5p (MIRT004445), hsa-mir-34b-3p (MIRT004519), hsa-mir-150-5p (MIRT004272), hsa-mir-29b-3p (MIRT003813), hsa-mir-503-5p (MIRT007224), hsa-mir-205-5p (MIRT004518), hsa-mir-15b-5p (MIRT004274), hsa-mir-200c-3p (MIRT006771), hsa-mir-133a-3p (MIRT021711), hsa-mir-147a (MIRT003810)

    Block miRNA regulation of human, mouse, rat VEGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VEGFA (see all 115):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-579 hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-520e hsa-miR-1321 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VEGFA
    Predesigned siRNA for gene silencing in human, mouse, rat VEGFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VEGFA

    Clone
    Products:
         
    OriGene clones in human, mouse for VEGFA (see all 80)
    OriGene ORF clones in mouse, rat for VEGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 18): VEGFA (NM_001204384)
    Sino Biological Human cDNA Clone for VEGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFA
    Addgene plasmids for VEGFA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VEGFA
    Browse ESI BIO Cell Lines and PureStem Progenitors for VEGFA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VEGFA_HUMAN, P15692: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has
    heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted.
    VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular
    matrix, although it may be released as a soluble form by heparin, heparinase or plasmin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    cytosol2
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    endosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS14570917
    GO:0005604basement membrane ----
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IDA17082651

    Find genes that share ontologies with VEGFA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VEGFA About   (see all 45)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    2Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    VEGF - VEGF R2 Signaling Pathways0.35
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    4Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Regulation of Gene Expression by Hypoxia-inducible Factor0.00
    Cellular response to hypoxia1.00
    5Signaling by VEGF
    Signaling by VEGF
    VEGF ligand-receptor interactions0.00
    VEGF binds to VEGFR leading to receptor dimerization0.00


    Find genes that share SuperPaths with VEGFA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for VEGFA
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VEGFA (see all 15)
        Relaxin Pathway
    VEGF Family Ligands and Receptor Interactions
    HIF1Alpha Pathway
    Colorectal Cancer Metastasis
    CRHR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for VEGFA (see all 10)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    Selected BioSystems Pathways for VEGFA (see all 17)
        Angiogenesis
    Heart Development
    SIDS Susceptibility Pathways
    Integrated Breast Cancer Pathway
    Endochondral Ossification

    1 Sino Biological Pathway for VEGFA
        VEGF Signaling

    4 Reactome Pathways for VEGFA
        VEGF ligand-receptor interactions
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation
    Regulation of gene expression by Hypoxia-inducible Factor

    2 PharmGKB Pathways for VEGFA
        Celecoxib Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for VEGFA) (see all 15):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    mTOR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFA (see all 42): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VEGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VEGFA (P156921, 2, 3 ENSP000003611254) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT1P179481, 3, ENSP000002823974EBI-1026643,EBI-1026718 I2D: score=5 STRING: ENSP00000282397
    NRP1O147861, 2, 3, ENSP000002653714EBI-1026643,EBI-1187100 MINT-2834244 MINT-2834194 MINT-2834269 I2D: score=4 STRING: ENSP00000265371
    TNXBP221053, ENSP000003643964I2D: score=1 STRING: ENSP00000364396
    KDRP359681, 2, 3, ENSP000002639234EBI-1026643,EBI-1005487 MINT-2834174 I2D: score=5 STRING: ENSP00000263923
    ENSG00000229353P221053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 118):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18093989
    GO:0001525angiogenesis IDA11427521
    GO:0001541ovarian follicle development ISS--
    GO:0001568blood vessel development ----
    GO:0001569patterning of blood vessels ISS--

    Find genes that share ontologies with VEGFA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VEGFA

    3 HMDB Compounds for VEGFA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    HeparinArteven (see all 17)9005-49-6--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10 DrugBank Compounds for VEGFA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ranibizumab-- 347396-82-1target--17049020 18054637 17046701 15671306 15973626 18035187 18046235 17031284 19668384 16935211
    Carvedilol-- 72956-09-3targetother15942707 11378004 15732037 15071347
    Gliclazide1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea (see all 5)21187-98-4targetother/unknown17602961 17046555 14746574 12126787
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor21091776 17692905 16041398
    Minocycline-- 10118-90-8targetinhibitor16224178 15256478 11875741
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423 10592235
    Tris(Hydroxymethyl)Aminomethane-- --target--17139284 17016423 10592235
    BevacizumabantiVEGF (see all 3)216974-75-3target--15705858 11752352
    AfliberceptAVE 0005 (see all 6)862111-32-8targetbinder22813448
    Vandetanib4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- (see all 4)443913-73-3targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for VEGFA gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 99.5 91016 9921991 (15), 10070308 (15), 15790460 (15), 15748443 (15) (see all 99)
    su5416 84.2 93 15474452 (5), 17169805 (4), 11156244 (3), 19420288 (3) (see all 51)
    pegaptanib 83.9 91 17509689 (3), 19668746 (3), 10548435 (2), 19734041 (2) (see all 54)
    matrigel 83.7 155 16447633 (2), 18080776 (2), 10634803 (2), 19616847 (2) (see all 99)
    ranibizumab 82.8 135 17714704 (5), 19643496 (4), 19674731 (3), 19553804 (3) (see all 66)
    sunitinib 82.2 97 17605814 (3), 19277038 (2), 17710208 (2), 18669461 (2) (see all 75)
    ptk787 80.7 50 10786682 (2), 19577260 (2), 15705616 (1), 15979888 (1) (see all 32)
    zd6474 80.1 52 19447868 (5), 19528456 (4), 12183421 (3), 19949019 (2) (see all 30)
    tyrosine 79.5 1237 19376222 (6), 9182576 (6), 10976958 (4), 9625748 (4) (see all 99)
    azd 2171 77.3 15 15899831 (1), 17592499 (1), 17906459 (1), 17634482 (1) (see all 12)

    9 PharmGKB related drug/compound annotations for VEGFA gene    About this table
    Drug/compound PharmGKB Annotation
    bevacizumabCA  
    cisplatinCA  
    cyclophosphamideCA  
    fluorouracilCA  
    oxaliplatinCA  
    ranibizumabCA  
    regorafenib
    sildenafilCA  
    sunitinibCA  



    Find genes that share compounds with VEGFA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for VEGFA gene (19 alternative transcripts): 
    NM_001025366.2  NM_001025367.2  NM_001025368.2  NM_001025369.2  NM_001025370.2  NM_001033756.2  NM_001171622.1  NM_001171623.1  
    NM_001171624.1  NM_001171625.1  NM_001171626.1  NM_001171627.1  NM_001171628.1  NM_001171629.1  NM_001171630.1  NM_001204384.1  
    NM_001204385.1  NM_001287044.1  NM_003376.5  

    Unigene Cluster for VEGFA:

    Vascular endothelial growth factor A
    Hs.73793  [show with all ESTs]
    Unigene Representative Sequence: NM_001025366
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000476772(uc003owb.3) ENST00000372067(uc003owd.3 uc010jyx.3 uc003owf.3 uc003owg.3 uc003owh.3 uc003owe.3 uc021yzu.1 uc003owj.3 uc003owi.3)
    ENST00000324450 ENST00000417285 ENST00000413642 ENST00000372055 ENST00000482630
    ENST00000425836 ENST00000372064 ENST00000372077 ENST00000519767 ENST00000520948
    ENST00000518538 ENST00000523873 ENST00000523950 ENST00000512683 ENST00000457104
    ENST00000518689
    miRNA
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    Block miRNA regulation of human, mouse, rat VEGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VEGFA (see all 115):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-579 hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-520e hsa-miR-1321 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene ORF clones in mouse, rat for VEGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 18): VEGFA (NM_001204384)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFA
    Addgene plasmids for VEGFA 
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      Search QuantiFast Probe-based Assays in human, mouse, rat VEGFA

    Additional mRNA sequence: 

    AB021221.1 AB451322.1 AB451451.1 AF022375.1 AF024710.1 AF062645.1 AF091352.1 AF214570.1 
    AF430806.1 AF486837.1 AJ010438.1 AK056914.1 AK125666.1 AY047581.1 AY263145.1 AY500353.1 
    AY766116.1 BC011177.1 BC019867.2 BC058855.1 BC065522.1 DQ229900.1 M27281.1 M32977.1 
    S85192.1 X62568.1 

    22 DOTS entries:

    DT.101962506  DT.100817302  DT.95350198  DT.95339476  DT.100743047  DT.453994  DT.101976085  DT.121334558 
    DT.92450656  DT.100817298  DT.100817299  DT.92450657  DT.100817293  DT.102828056  DT.121334539  DT.40235175 
    DT.92450653  DT.100817297  DT.92450650  DT.92450651  DT.95182536  DT.95262131 

    Selected AceView cDNA sequences (see all 416):

    CK904368 W96086 AI445310 AI350251 AA923135 AI648395 AA328734 BM053003 
    AA285020 BF340289 BM784157 AW954305 AF430806 CA423132 BF932984 AI085744 
    AI811828 AA992216 CR592173 AA947016 CA393932 CD617014 AB021221 BF513548 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                          -     -                                         -     -                                 
    SP2:                          -     -                                               -                                 
    SP3:                          -     -                             -     -     -     -                                 
    SP4:                          -     -                                   -     -     -                                 
    SP5:                          -     -                             -     -     -     -           -                     


    ECgene alternative splicing isoforms for VEGFA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    VEGFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCAATCT
    VEGFA Expression
    About this image


    VEGFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 43) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 27 entries
             Terminal Chondrocytes Endochondral Facial Bones
             Stylopod Long Bone
             Bone marrow-derived mesenchymal stem cells (HYNR-CS inj)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 13 entries
             Hypertrophic Chondrocytes Temporomandibular Joint
     
     Endothelium (Cardiovascular System)    fully expand to see all 6 entries
             Pericytes Microvessels
             Angiogenic cell precursor
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Hemangioblasts Posterior Primitive Streak
             Angiogenic cell precursor
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Pericytes Blood Brain Barrier
             Cerebellum
    VEGFA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VEGFA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73793

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and
    isoform VEGF145 are not widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFA (see all 42): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vegfa1 , 5 vascular endothelial growth factor A1, 5 88.52(n)1
    83.93(a)1
      17 (22.79 cM)5
    223391  NM_001025250.31  NP_001020421.21 
     460169935 
    chicken
    (Gallus gallus)
    Aves VEGFA1 vascular endothelial growth factor A 78.29(n)
    74.88(a)
      395909  NM_205042.2  NP_990373.1 
    lizard
    (Anolis carolinensis)
    Reptilia VEGFA6
    vascular endothelial growth factor A
    67(a)
    1 ↔ 1
    1(226686337-226708550)
    African clawed frog
    (Xenopus laevis)
    Amphibia vegf-A2 vascular endothelial growth factor 82.81(n)    AF008594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vegf2 vascular endothelial growth factor 75.7(n)   30682  AF016244.1 


    ENSEMBL Gene Tree for VEGFA (if available)
    TreeFam Gene Tree for VEGFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VEGFA gene
    PGF2  VEGFB2  
    4 SIMAP similar genes for VEGFA using alignment to 13 protein entries:     VEGFA_HUMAN (see all proteins):
    VEGF    VEGF41    PGF    VEGFB

    Find genes that share paralogs with VEGFA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VEGFA (see all 450)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122081521,2
    C,F--43456140(+) TATCCC/TGTTCA 18 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1481678191,2
    --43456189(+) TGGGAC/GGGGGC 18 -- us2k10--------
    rs1807507811,2
    --43456272(+) GTGGAC/GACAGG 18 -- us2k10--------
    rs770646981,2
    C--43456281(+) GGACTA/CGTGCA 18 -- us2k10--------
    rs1846110631,2
    C--43456287(+) GTGCAC/TGAATG 18 -- us2k10--------
    rs1461336971,2
    --43456356(+) GACACC/TATACC 18 -- us2k10--------
    rs343769961,2
    C,F--43456481(+) GGAAAT/CTGCTG 18 -- us2k16Minor allele frequency- C:0.02MN WA 522
    rs126641041,2
    H--43456534(+) CTGTAG/TGCCAG 18 -- us2k10--------
    rs6999471,2
    C,F,A,H--43456549(+) TGGCAC/AGATCT 18 -- us2k130Minor allele frequency- A:0.38EA MN NS NA WA CSA 3292
    rs2010743851,2
    C--43456578(+) ACTGGC/TCCCAC 18 -- us2k10--------

    HapMap Linkage Disequilibrium report for VEGFA (43737921 - 43754224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VEGFA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885848CNV Loss21882294
    nsv885850CNV Loss21882294
    nsv823682CNV Gain20364138
    nsv885849CNV Gain21882294

    Human Gene Mutation Database (HGMD): VEGFA
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing VEGFA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    SeqTarget long-range PCR primers for resequencing VEGFA
    DNA2.0 Custom Variant and Variant Library Synthesis for VEGFA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192240   
    OMIM disorders: 603933  
    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
  • Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in
    numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic
    nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major
    cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased
    tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • Selected diseases for VEGFA (see all 92):    
    About MalaCards
    diabetic retinopathy    poems syndrome    microvascular complications of diabetes 1    macular retinal edema
    mucinous adenocarcinoma of the appendix    glomeruloid hemangioma    diabetic macular edema    proliferative diabetic retinopathy
    progressive supranuclear palsy    angiolipoma    neovascular glaucoma    retinal vascular disease
    estrogen-receptor positive breast cancer    hemangioblastoma    adamantinous craniopharyngioma    pulmonary aspergilloma
    retinal ischemia    engraftment syndrome    retinal hemangioblastoma    kuhnt-junius degeneration

    Selected diseases from the University of Copenhagen DISEASES database for VEGFA (see all 30):
    Age related macular degeneration     Kuhnt-Junius degeneration     Diabetic retinopathy     Vascular disease
    Retinopathy of prematurity     Macular retinal edema     Colorectal cancer     Carcinoma
    Breast cancer     Malignant glioma     Lung cancer     Renal cell carcinoma
    Blindness     Neovascular glaucoma     Retinal vein occlusion     Keratitis
    Ovarian cancer     Heart disease     Melanoma     POEMS syndrome

    Find genes that share disorders with VEGFA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VEGFA gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 92.9 1184 10406801 (4), 16179869 (4), 19639355 (4), 9815760 (4) (see all 99)
    tumors 88.1 9908 16222693 (9), 11176129 (9), 1940805 (9), 15699727 (8) (see all 99)
    metastasis 83.9 1955 15473929 (8), 12926153 (6), 10070308 (6), 17283532 (6) (see all 99)
    cancer 80.7 1954 9933044 (8), 12726933 (6), 19633424 (6), 10853032 (6) (see all 99)
    proliferative diabetic retinopathy 80.2 196 7943121 (4), 11935151 (4), 15767056 (3), 18053608 (3) (see all 95)
    diabetic retinopathy 79.8 354 19216096 (5), 19646547 (4), 11440280 (4), 11642376 (4) (see all 99)
    solid tumor 79.7 294 11734110 (3), 10811135 (3), 11297245 (2), 11776866 (2) (see all 99)
    retinal neovascularization 78 88 16936124 (4), 7479819 (3), 16785756 (3), 11740151 (2) (see all 43)
    choroidal neovascularization 76.2 124 10410552 (3), 10484206 (2), 15389527 (2), 18728623 (2) (see all 74)
    retinopathy 73.9 314 11437859 (4), 18382886 (4), 20169883 (4), 9046048 (4) (see all 99)

    Genetic Association Database (GAD): VEGFA
    Human Genome Epidemiology (HuGE) Navigator: VEGFA (439 documents)

    Export disorders for VEGFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VEGFA gene, integrated from 10 sources (see all 9296):
    (articles sorted by number of sources associating them with VEGFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. (PubMed id 11978667)1, 2, 4, 9 Awata T.... Katayama S. (Diabetes 2002)
    2. Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients. (PubMed id 15086939)1, 4, 9 Szeto C.C....Li P.K. (Kidney Int. 2004)
    3. The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding. (PubMed id 9351807)1, 2, 9 Muller Y.A.... de Vos A.M. (Structure 1997)
    4. The clinical role of vascular endothelial growth factor (VEGF) system in the pathogenesis of retinopathy of prematurity. (PubMed id 18546007)1, 4, 9 Kwinta P....Pietrzyk J.J. (Graefes Arch. Clin. Exp. Ophthalmol. 2008)
    5. Influence of VEGF-A gene variation and protein levels in breast cancer susceptibility and severity. (PubMed id 17471570)1, 4, 9 Balasubramanian S.P....Reed M.W. (Int. J. Cancer 2007)
    6. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. (PubMed id 15541813)1, 4, 9 Koukourakis M.I....Siviridis E. (Lung Cancer 2004)
    7. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. (PubMed id 18223238)1, 4, 9 Zhai R....Christiani D.C. (Clin. Cancer Res. 2008)
    8. Vascular endothelial growth factor polymorphisms (-460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression. (PubMed id 18930211)1, 4, 9 CosA-n R....EstellAcs A. (Fertil. Steril. 2009)
    9. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. (PubMed id 20019880)1, 4, 9 Fang A.M....Brantley M.A. (Mol. Vis. 2009)
    10. Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. (PubMed id 15767331)1, 4, 9 Lee S.J....Park J.Y. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7422 HGNC: 12680 AceView: VEGF Ensembl:ENSG00000112715 euGenes: HUgn7422
    ECgene: VEGFA Kegg: 7422 H-InvDB: VEGFA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VEGFA Pharmacogenomics, SNPs, Pathways
    R&D Systems' cytokine mini-reviews: VEGFhttp://www.rndsystems.com/molecule_detail.aspx?m=2247
    Wikipedia http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
    SeattleSNPshttp://pga.gs.washington.edu/data/vegf/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VEGFA gene:
    Search GeneIP for patents involving VEGFA

    Licensable Technologies for VEGFA gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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