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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VEGFA Gene

protein-coding   GIFtS: 70
GCID: GC06P043737

Vascular Endothelial Growth Factor A

(Previous name: vascular endothelial growth factor)
(Previous symbol: VEGF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vascular Endothelial Growth Factor A1 2     MVCD12 5
VEGF1 2 3 5     Vascular Endothelial Growth Factor1
Vascular Permeability Factor2 3     VEGF-A3
VPF2 3     

External Ids:    HGNC: 126801   Entrez Gene: 74222   Ensembl: ENSG000001127157   OMIM: 1922405   UniProtKB: P156923   

Export aliases for VEGFA gene to outside databases

Previous GC identifers: GC06P043846 GC06P043458


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VEGFA Gene:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a
disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells
and has various effects, including mediating increased vascular permeability, inducing angiogenesis,
vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels
of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been
associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript
variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also
evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG,
leading to additional isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for VEGFA Gene: 
VEGFA (vascular endothelial growth factor A) is a protein-coding gene. Diseases associated with VEGFA include diabetic retinopathy, and poems syndrome, and among its related super-pathways are Development VEGF signaling via VEGFR2 - generic cascades and Translation Insulin regulation of translation. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial
cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms
VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does
not activate angiogenesis and inhibits tumor growth

Gene Wiki entry for VEGFA (Vascular endothelial growth factor A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VEGFA gene promoter:
         PPAR-alpha   PPAR-gamma1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): VEGFA promoter sequence
   Search SABiosciences Chromatin IP Primers for VEGFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

VEGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043737:  view genomic region     (about GC identifiers)

Start:
43,737,921 bp from pter      End:
43,754,224 bp from pter
Size:
16,304 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692 (See protein sequence)
Recommended Name: Vascular endothelial growth factor A precursor  
Size: 232 amino acids; 27042 Da
Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity)
Subcellular location: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has
heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted.
VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular
matrix, although it may be released as a soluble form by heparin, heparinase or plasmin
Sequence caution: Sequence=AAC63102.1; Type=Erroneous initiation; Sequence=AAC63143.1; Type=Miscellaneous
discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator.
The initiator methionine is coded by a non-canonical CTG leucine codon;
6/28 PDB 3D structures from and Proteopedia for VEGFA (see all 28):
1BJ1 (3D)        1CZ8 (3D)        1FLT (3D)        1KAT (3D)        1KMX (3D)        1MJV (3D)    
Secondary accessions: B5BU86 O60720 O75875 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5
Q9H1W8 Q9H1W9 Q9UH58 Q9UL23
Alternative promoter usage, Alternative splicing, Alternative initiation: 13 isoforms:  P15692-1   P15692-2   P15692-3   P15692-4   P15692-5   P15692-6   P15692-8   P15692-9   
P15692-10   P15692-11   P15692-12   P15692-13   P15692-14   (Gene prediction based on EST data. Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon)

Explore the universe of human proteins at neXtProt for VEGFA: NX_P15692

Explore proteomics data for VEGFA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15692

  • VEGFA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VEGFA Protein Expression
    REFSEQ proteins (18 alternative transcripts): 
    NP_001020537.2  NP_001020538.2  NP_001020539.2  NP_001020540.2  NP_001020541.2  NP_001028928.1  NP_001165093.1  NP_001165094.1  
    NP_001165095.1  NP_001165096.1  NP_001165097.1  NP_001165098.1  NP_001165099.1  NP_001165100.1  NP_001165101.1  NP_001191313.1  
    NP_001191314.1  NP_003367.4  

    ENSEMBL proteins: 
     ENSP00000361137   ENSP00000317598   ENSP00000388663   ENSP00000389864   ENSP00000361125  
     ENSP00000421561   ENSP00000388465   ENSP00000361134   ENSP00000361148   ENSP00000430594  
     ENSP00000428321   ENSP00000430479   ENSP00000429643   ENSP00000409911   ENSP00000430829  
     ENSP00000429008   ENSP00000430002   ENSP00000230480   ENSP00000429592  
    Reactome Protein details: P15692
    Human Recombinant Protein Products for VEGFA: 
    EMD Millipore Purified and/or Recombinant VEGFA Protein
    R&D Systems Recombinant & Natural Proteins for VEGFA (VEGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VEGFA
    OriGene Protein Over-expression Lysate for VEGFA
    OriGene MassSpec for VEGFA 
    OriGene Custom Protein Services for VEGFA
    GenScript Purified and Recombinant Proteins for VEGFA
    Novus Biologicals VEGFA Proteins
    Novus Biologicals VEGFA Lysates
    Sino Biological Recombinant Protein for VEGFA
    Sino Biological Cell Lysate for VEGFA 
    ProSpec Recombinant Protein for VEGFA
    Cloud-Clone Corp. Proteins for VEGFA 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS14570917
    GO:0005604basement membrane ----
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IDA17082651

    VEGFA for ontologies           About GeneDecksing



    VEGFA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of VEGFA
    R&D Systems Antibodies for VEGFA (VEGF)
    OriGene Antibodies for VEGFA
    OriGene Custom Antibody Services for VEGFA
    GenScript Custom Superior Antibodies Services for VEGFA
    Novus Biologicals VEGFA Antibodies
    Abcam antibodies for VEGFA
    Cloud-Clone Corp. Antibodies for VEGFA 
    ThermoFisher Antibody for VEGFA
    LSBio Antibodies in human, mouse, rat for VEGFA 

    Assay Products for VEGFA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VEGFA
    R&D Systems Flow Cytometry Kits for VEGFA (VEGF)         (see all)
    GenScript Custom Assay Services for VEGFA
    Enzo Life Sciences assays for VEGFA
    Cloud-Clone Corp. ELISAs for VEGFA 
    Cloud-Clone Corp. CLIAs for VEGFA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000072 PD_growth_factor
     IPR023581 PD_growth_factor_CS

    Graphical View of Domain Structure for InterPro Entry P15692

    ProtoNet protein and cluster: P15692

    1 Blocks protein domain: IPB000072 Platelet-derived growth factor (PDGF)

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Similarity: Belongs to the PDGF/VEGF growth factor family


    VEGFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFA_HUMAN, P15692
    Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial
    cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
    Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms
    VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does
    not activate angiogenesis and inhibits tumor growth
    Induction: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and
    oncogenic mutations

         Summary:

    During embryonic development, VEGFA as signaling molecule is secreted from the following cells: Ectoderm Cells in Branchial Arch 2, Hypertrophic Chondrocytes in Stylopod Growth Plate (see all 14).

    It affects the following cells: Angioblasts in Perineural capillary Plexus, Arterial Endothelial Cells in Paired Dorsal Aorta (see all 15).

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IDA14570917
    GO:0005125cytokine activity ISS--
    GO:0005161platelet-derived growth factor receptor binding IPI17470632
    GO:0005172vascular endothelial growth factor receptor binding IPI10471394
    GO:0005515protein binding IPI10543948
         
    VEGFA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VEGFA:
     Decreased focal adhesion (FA)  

         15/25 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Vegfa) (see all 25):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    VEGFA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for VEGFA: Vegfatm1Gne Vegfatm1Dco Vegfatm2Pec Vegfatm1Pec

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VEGFA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VEGFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VEGFA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VEGFA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target VEGFA:
    hsa-mir-34a (MIRT004513), hsa-mir-378 (MIRT004277), hsa-mir-17 (MIRT004271), hsa-mir-330-3p (MIRT004278), hsa-mir-140-5p (MIRT003812), hsa-mir-520h (MIRT004458), hsa-mir-20b (MIRT004451), hsa-mir-20a (MIRT004450), hsa-mir-125a-5p (MIRT004445), hsa-mir-107 (MIRT003814), hsa-mir-372 (MIRT004461), hsa-mir-383 (MIRT004443), hsa-mir-34b (MIRT004519), hsa-mir-302d (MIRT000722), hsa-mir-29b (MIRT003813), hsa-mir-150 (MIRT004272), hsa-mir-16 (MIRT003890), hsa-mir-504 (MIRT004457), hsa-mir-361-5p (MIRT004447), hsa-mir-126 (MIRT003428), hsa-mir-93 (MIRT004055), hsa-mir-205 (MIRT004518), hsa-mir-15a (MIRT004275), hsa-mir-134 (MIRT003811), hsa-mir-106a (MIRT004465), hsa-mir-373 (MIRT000721), hsa-mir-15b (MIRT004274), hsa-mir-106b (MIRT004466), hsa-mir-195 (MIRT004273), hsa-mir-147 (MIRT003810), hsa-mir-520g (MIRT004276)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEGFA
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate VEGFA (see all 115):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-579 hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-520e hsa-miR-1321 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VEGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEGFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VEGFA
    Sirion Biotech Customized adenovirus for overexpression of VEGFA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VEGFA (see all 71)
    OriGene ORF clones in mouse, rat for VEGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 18): VEGFA (NM_001204384)
    Sino Biological Human cDNA Clone for VEGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFA
    Sirion Biotech Customized lentivirus for stable overexpression of VEGFA 
                         Customized lentivirus expression plasmids for stable overexpression of VEGFA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VEGFA
    Search LifeMap BioReagents cell lines for VEGFA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VEGFA About   (see all 42)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.75
    VEGF - VEGF R2 Signaling Pathways 0.39
    Development VEGF signaling and activation0.75
    2Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    4Cellular response to hypoxia
    Cellular response to hypoxia0.72
    Cellular responses to stress0.72
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    Regulation of Gene Expression by Hypoxia-inducible Factor0.36
    5Signaling by VEGF
    Signaling by VEGF0.80
    VEGF binds to VEGFR leading to receptor dimerization0.80
    VEGF ligand-receptor interactions0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for VEGFA (see all 10)
        Development VEGF signaling and activation
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Cytoskeleton remodeling FAK signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    1 R&D Systems Pathway for VEGFA
        VEGF - VEGF R2 Signaling Pathways


    5/10 GeneGo (Thomson Reuters) Pathways for VEGFA (see all 10)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/16 BioSystems Pathways for VEGFA (see all 16)
        Angiogenesis
    Heart Development
    SIDS Susceptibility Pathways
    Integrated Breast Cancer Pathway
    Endochondral Ossification

    1 Sino Biological Pathway for VEGFA 
        VEGF Signaling

    5/12        Reactome Pathways for VEGFA (see all 12)
        Cellular response to hypoxia
    Hemostasis
    VEGF binds to VEGFR leading to receptor dimerization
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Response to elevated platelet cytosolic Ca2+

    2 PharmGKB Pathways for VEGFA
        Celecoxib Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/13         Kegg Pathways  (Kegg details for VEGFA) (see all 13):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    VEGF signaling pathway


    VEGFA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VEGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for VEGFA (P156921, 2, 3 ENSP000003611254) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT1P179481, 3, ENSP000002823974EBI-1026643,EBI-1026718 I2D: score=5 STRING: ENSP00000282397
    NRP1O147862, 3, ENSP000002653714MINT-2834244 MINT-2834194 MINT-2834269 I2D: score=4 STRING: ENSP00000265371
    TNXBP221053, ENSP000003643964I2D: score=1 STRING: ENSP00000364396
    KDRP359681, 2, 3, ENSP000002639234EBI-1026691,EBI-1005487 MINT-2834174 I2D: score=5 STRING: ENSP00000263923
    ENSG00000229353P221053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/108 biological process terms (GO ID links to tree view) (see all 108):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18093989
    GO:0001525angiogenesis IDA11427521
    GO:0001541ovarian follicle development ISS--
    GO:0001568blood vessel development ----
    GO:0001569patterning of blood vessels ISS--

    VEGFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VEGFA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VEGFA

    3 HMDB Compounds for VEGFA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    HeparinArteven (see all 17)9005-49-6--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10 DrugBank Compounds for VEGFA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ranibizumab-- 347396-82-1target--17049020 18054637 17046701 15671306 15973626 18035187 18046235 17031284 19668384 16935211
    Carvedilol-- 72956-09-3targetother15942707 11378004 15732037 15071347
    Gliclazide1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea (see all 5)21187-98-4targetother/unknown17602961 17046555 14746574 12126787
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor21091776 17692905 16041398
    Minocycline-- 10118-90-8targetinhibitor16224178 15256478 11875741
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423 10592235
    Tris(Hydroxymethyl)Aminomethane-- --target--17139284 17016423 10592235
    BevacizumabantiVEGF (see all 3)216974-75-3target--15705858 11752352
    AfliberceptAVE 0005 (see all 6)862111-32-8targetbinder22813448
    Vandetanib4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- (see all 4)443913-73-3targetinhibitor--

    10/106 Novoseek inferred chemical compound relationships for VEGFA gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 99.5 91016 9921991 (15), 10070308 (15), 15790460 (15), 15748443 (15) (see all 99)
    su5416 84.2 93 15474452 (5), 17169805 (4), 11156244 (3), 19420288 (3) (see all 51)
    pegaptanib 83.9 91 17509689 (3), 19668746 (3), 10548435 (2), 19734041 (2) (see all 54)
    matrigel 83.7 155 16447633 (2), 18080776 (2), 10634803 (2), 19616847 (2) (see all 99)
    ranibizumab 82.8 135 17714704 (5), 19643496 (4), 19674731 (3), 19553804 (3) (see all 66)
    sunitinib 82.2 97 17605814 (3), 19277038 (2), 17710208 (2), 18669461 (2) (see all 75)
    ptk787 80.7 50 10786682 (2), 19577260 (2), 15705616 (1), 15979888 (1) (see all 32)
    zd6474 80.1 52 19447868 (5), 19528456 (4), 12183421 (3), 19949019 (2) (see all 30)
    tyrosine 79.5 1237 19376222 (6), 9182576 (6), 10976958 (4), 9625748 (4) (see all 99)
    azd 2171 77.3 15 15899831 (1), 17592499 (1), 17906459 (1), 17634482 (1) (see all 12)

    2 PharmGKB related drug/compound annotations for VEGFA gene    About this table
    Drug/compound PharmGKB Annotation
    ranibizumabCA  
    sunitinibCA  

    Search CenterWatch for drugs/clinical trials and news about VEGFA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for VEGFA gene (18 alternative transcripts): 
    NM_001025366.2  NM_001025367.2  NM_001025368.2  NM_001025369.2  NM_001025370.2  NM_001033756.2  NM_001171622.1  NM_001171623.1  
    NM_001171624.1  NM_001171625.1  NM_001171626.1  NM_001171627.1  NM_001171628.1  NM_001171629.1  NM_001171630.1  NM_001204384.1  
    NM_001204385.1  NM_003376.5  

    Unigene Cluster for VEGFA:

    Vascular endothelial growth factor A
    Hs.73793  [show with all ESTs]
    Unigene Representative Sequence: NM_001025366
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000476772(uc003owb.3) ENST00000372067(uc003owd.3 uc010jyx.3 uc003owf.3 uc003owg.3 uc003owh.3 uc003owe.3 uc021yzu.1 uc003owj.3 uc003owi.3)
    ENST00000324450 ENST00000417285 ENST00000413642 ENST00000372055 ENST00000482630
    ENST00000425836 ENST00000372064 ENST00000372077 ENST00000519767 ENST00000520948
    ENST00000518538 ENST00000523873 ENST00000523950 ENST00000512683 ENST00000457104
    ENST00000518689
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB021221.1 AB451322.1 AB451451.1 AF022375.1 AF024710.1 AF062645.1 AF091352.1 AF214570.1 
    AF430806.1 AF486837.1 AJ010438.1 AK056914.1 AK125666.1 AY047581.1 AY263145.1 AY500353.1 
    AY766116.1 BC011177.1 BC019867.2 BC058855.1 BC065522.1 DQ229900.1 M27281.1 M32977.1 
    S85192.1 X62568.1 

    22 DOTS entries:

    DT.101962506  DT.100817302  DT.95350198  DT.95339476  DT.100743047  DT.453994  DT.100817298  DT.121334558 
    DT.100817299  DT.101976085  DT.92450656  DT.92450657  DT.100817293  DT.102828056  DT.121334539  DT.40235175 
    DT.92450653  DT.100817297  DT.92450650  DT.92450651  DT.95182536  DT.95262131 

    24/416 AceView cDNA sequences (see all 416):

    BG054972 BM053002 BU733597 BG055994 AB021221 BF513548 CA444112 BC065522 
    BQ051299 BQ006682 CD106271 BM970555 CR592173 BM689711 W96086 AI648395 
    NM_003376 AA878959 CA435189 BF338907 CA393932 AA328734 AI445310 AJ010438 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                          -     -                                         -     -                                 
    SP2:                          -     -                                               -                                 
    SP3:                          -     -                             -     -     -     -                                 
    SP4:                          -     -                                   -     -     -                                 
    SP5:                          -     -                             -     -     -     -           -                     


    ECgene alternative splicing isoforms for VEGFA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VEGFA expression in normal human tissues (normalized intensities)      VEGFA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCAATCT
    VEGFA Expression
    About this image


    VEGFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 48 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             Zeugopod Long Bone
             GLP-transfected mesenchymal stem cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 36 entries
             Terminal Chondrocytes Temporomandibular Joint
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Pericytes Blood Brain Barrier
             Amygdala
             Septum   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
             Human Mesenchymal Stem Cells (hMSC)   
     
     Somite (Muscoskeletal System)    fully expand to see all 5 entries
             Thoracic Somite Cells Thoracic Somites

    See VEGFA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VEGFA

    SOURCE GeneReport for Unigene cluster: Hs.73793

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and
    isoform VEGF145 are not widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including VEGFA (see all 42): 
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              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFA gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vegfa1 , 5 vascular endothelial growth factor A1, 5 89.03(n)1
    84.44(a)1
      17 (22.79 cM)5
    223391  NM_001025250.31  NP_001020421.21 
     460169935 
    chicken
    (Gallus gallus)
    Aves VEGFA1 vascular endothelial growth factor A 78.29(n)
    74.88(a)
      395909  NM_205042.2  NP_990373.1 
    lizard
    (Anolis carolinensis)
    Reptilia VEGFA6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    1(226686337-226708550)
    African clawed frog
    (Xenopus laevis)
    Amphibia vegf-A2 vascular endothelial growth factor 82.81(n)    AF008594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vegf2 vascular endothelial growth factor 75.7(n)   30682  AF016244.1 


    ENSEMBL Gene Tree for VEGFA (if available)
    TreeFam Gene Tree for VEGFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VEGFA gene
    PGF2  VEGFB2  
    4 SIMAP similar genes for VEGFA using alignment to 13 protein entries:     VEGFA_HUMAN (see all proteins):
    VEGF    VEGF41    PGF    VEGFB

    VEGFA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/450 SNPs in VEGFA are shown (see all 450)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122081521,2
    C,F--43456140(+) TATCCC/TGTTCA 18 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1481678191,2
    --43456189(+) TGGGAC/GGGGGC 18 -- us2k10--------
    rs1807507811,2
    --43456272(+) GTGGAC/GACAGG 18 -- us2k10--------
    rs770646981,2
    C--43456281(+) GGACTA/CGTGCA 18 -- us2k10--------
    rs1846110631,2
    C--43456287(+) GTGCAC/TGAATG 18 -- us2k10--------
    rs1461336971,2
    --43456356(+) GACACC/TATACC 18 -- us2k10--------
    rs343769961,2
    C,F--43456481(+) GGAAAT/CTGCTG 18 -- us2k16Minor allele frequency- C:0.02MN WA 522
    rs126641041,2
    H--43456534(+) CTGTAG/TGCCAG 18 -- us2k10--------
    rs6999471,2
    C,F,A,H--43456549(+) TGGCAC/AGATCT 18 -- us2k130Minor allele frequency- A:0.38EA MN NS NA WA CSA 3292
    rs2010743851,2
    C--43456578(+) ACTGGC/TCCCAC 18 -- us2k10--------

    HapMap Linkage Disequilibrium report for VEGFA (43737921 - 43754224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VEGFA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885848CNV Loss21882294
    nsv885850CNV Loss21882294
    nsv823682CNV Gain20364138
    nsv885849CNV Gain21882294


    Human Gene Mutation Database (HGMD): VEGFA
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    Lung Cancer
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    DNA2.0 Custom Variant and Variant Library Synthesis for VEGFA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192240   
    OMIM disorders: 603933  
    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
  • Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in
    numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic
    nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major
    cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased
    tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 20/489 diseases for VEGFA (see all 489):    About MalaCards
    diabetic retinopathy    poems syndrome    severe nonproliferative diabetic retinopathy    macular retinal edema
    microvascular complications of diabetes 1    rubeosis iridis    proliferative diabetic retinopathy    diabetic macular edema
    retinal vascular disease    hemangioma of liver    adamantinous craniopharyngioma    lung cancer, resistance to
    progressive supranuclear palsy - corticobasal syndrome    kaposi's sarcoma    hemangioblastoma    neovascular glaucoma
    meigs syndrome    retinal ischemia    angiolipoma    pulmonary aspergilloma

    20/30 diseases from the University of Copenhagen DISEASES database for VEGFA (see all 30):
    Age related macular degeneration     Kuhnt-Junius degeneration     Diabetic retinopathy     Vascular disease
    Retinopathy of prematurity     Macular retinal edema     Colorectal cancer     Carcinoma
    Breast cancer     Malignant glioma     Lung cancer     Renal cell carcinoma
    Blindness     Neovascular glaucoma     Retinal vein occlusion     Keratitis
    Ovarian cancer     Heart disease     Melanoma     POEMS syndrome

    VEGFA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for VEGFA gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 92.9 1184 10406801 (4), 16179869 (4), 19639355 (4), 9815760 (4) (see all 99)
    tumors 88.1 9908 16222693 (9), 11176129 (9), 1940805 (9), 15699727 (8) (see all 99)
    metastasis 83.9 1955 15473929 (8), 12926153 (6), 10070308 (6), 17283532 (6) (see all 99)
    cancer 80.7 1954 9933044 (8), 12726933 (6), 19633424 (6), 10853032 (6) (see all 99)
    proliferative diabetic retinopathy 80.2 196 7943121 (4), 11935151 (4), 15767056 (3), 18053608 (3) (see all 95)
    diabetic retinopathy 79.8 354 19216096 (5), 19646547 (4), 11440280 (4), 11642376 (4) (see all 99)
    solid tumor 79.7 294 11734110 (3), 10811135 (3), 11297245 (2), 11776866 (2) (see all 99)
    retinal neovascularization 78 88 16936124 (4), 7479819 (3), 16785756 (3), 11740151 (2) (see all 43)
    choroidal neovascularization 76.2 124 10410552 (3), 10484206 (2), 15389527 (2), 18728623 (2) (see all 74)
    retinopathy 73.9 314 11437859 (4), 18382886 (4), 20169883 (4), 9046048 (4) (see all 99)

    Genetic Association Database (GAD): VEGFA
    Human Genome Epidemiology (HuGE) Navigator: VEGFA (439 documents)

    Export disorders for VEGFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VEGFA gene, integrated from 9 sources (see all 9155):
    (articles sorted by number of sources associating them with VEGFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. (PubMed id 11978667)1, 2, 4, 9 Awata T....Katayama S. (2002)
    2. Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients. (PubMed id 15086939)1, 4, 9 Szeto C.C....Li P.K. (2004)
    3. The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding. (PubMed id 9351807)1, 2, 9 Muller Y.A.... de Vos A.M. (1997)
    4. The clinical role of vascular endothelial growth factor (VEGF) system in the pathogenesis of retinopathy of prematurity. (PubMed id 18546007)1, 4, 9 Kwinta P....Pietrzyk J.J. (2008)
    5. Influence of VEGF-A gene variation and protein levels in breast cancer susceptibility and severity. (PubMed id 17471570)1, 4, 9 Balasubramanian S.P....Reed M.W. (2007)
    6. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. (PubMed id 15541813)1, 4, 9 Koukourakis M.I....Siviridis E. (2004)
    7. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. (PubMed id 18223238)1, 4, 9 Zhai R....Christiani D.C. (2008)
    8. Polymorphisms in the VEGFA and VEGFR-2 genes and neov ascular age-related macular degeneration. (PubMed id 20019880)1, 4, 9 Fang A.M....Brantley M.A. (2009)
    9. Vascular endothelial growth factor polymorphisms (-460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression. (PubMed id 18930211)1, 4, 9 Cosin R....Estelles A. (2008)
    10. Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. (PubMed id 15767331)1, 4, 9 Lee S.J....Park J.Y. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7422 HGNC: 12680 AceView: VEGF Ensembl:ENSG00000112715 euGenes: HUgn7422
    ECgene: VEGFA Kegg: 7422 H-InvDB: VEGFA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VEGFA Pharmacogenomics, SNPs, Pathways
    R&D Systems' cytokine mini-reviews: VEGFhttp://www.rndsystems.com/molecule_detail.aspx?m=2247
    Wikipedia http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
    SeattleSNPshttp://pga.gs.washington.edu/data/vegf/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VEGFA gene:
    Search GeneIP for patents involving VEGFA

    Licensable Technologies for VEGFA gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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