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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VEGFA Gene

protein-coding   GIFtS: 71
GCID: GC06P043737

vascular endothelial growth factor A

(Previous name: vascular endothelial growth factor )
(Previous symbol: VEGF)
 Explore 524 diseases affiliated with
VEGFA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VEGFA    

Aliases
for VEGFA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vascular Endothelial Growth Factor A1 2     Vascular Permeability Factor2 3
VEGF1 2 3 5     MVCD12 5
VPF1 2 3     Vascular Endothelial Growth Factor1
VEGF-A1 3     

External Ids:    HGNC: 126801   Entrez Gene: 74222   Ensembl: ENSG000001127157   OMIM: 1922405   UniProtKB: P156923   

Export aliases for VEGFA gene to outside databases

Previous GC identifers: GC06P043846 GC06P043458


Summaries
for VEGFA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VEGFA:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide
linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various
effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial
cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS
syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and
nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or
cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation
initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell
proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the
FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and
VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate
angiogenesis and inhibits tumor growth

summary for VEGFA:
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and
vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have
been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the
majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a
dummy/decoy receptor to sequester VEGF away from VEGFR-2.

Gene Wiki entry for VEGFA (Vascular endothelial growth factor A)


Genomic Views
for VEGFA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VEGFA gene promoter:
         PPAR-alpha   PPAR-gamma1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): VEGFA promoter sequence
   Search SABiosciences Chromatin IP Primers for VEGFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

VEGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043737:  view genomic region     (about GC identifiers)

Start:
 43,737,921 bp from pter      End:
 43,754,224 bp from pter
Size:
 16,304 bases      Orientation:
 plus strand

Proteins
for VEGFA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692 (See protein sequence)
Recommended Name: Vascular endothelial growth factor A precursor  
Size: 232 amino acids; 27042 Da
Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity)
Subcellular location: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding
properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very
basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it
may be released as a soluble form by heparin, heparinase or plasmin
Sequence caution: Sequence=AAC63102.1; Type=Erroneous initiation; Sequence=AAC63143.1; Type=Miscellaneous discrepancy;
Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAC19512.2;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG
leucine codon; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine
is coded by a non-canonical CTG leucine codon;
6/28 PDB 3D structures from and Proteopedia for VEGFA (see all 28):
1BJ1 (3D)        1CZ8 (3D)        1FLT (3D)        1KAT (3D)        1KMX (3D)        1MJV (3D)    
Secondary accessions: B5BU86 O60720 O75875 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5 Q9H1W8
Q9H1W9 Q9UH58 Q9UL23
Alternative promoter usage, Alternative splicing, Alternative initiation: 13 isoforms:  P15692-1   P15692-2   P15692-3   P15692-4   P15692-5   P15692-6   P15692-8   P15692-9   
P15692-10   P15692-11   P15692-12   P15692-13   P15692-14   (Gene prediction based on EST data. Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon)

Explore the universe of human proteins at neXtProt for VEGFA: NX_P15692

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15692

    • VEGFA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (18 alternative transcripts): 
    NP_001020537.2  NP_001020538.2  NP_001020539.2  NP_001020540.2  NP_001020541.2  NP_001028928.1  NP_001165093.1  NP_001165094.1  
    NP_001165095.1  NP_001165096.1  NP_001165097.1  NP_001165098.1  NP_001165099.1  NP_001165100.1  NP_001165101.1  NP_001191313.1  
    NP_001191314.1  NP_003367.4  

    ENSEMBL proteins: 
     ENSP00000361137   ENSP00000317598   ENSP00000388663   ENSP00000389864   ENSP00000361125  
     ENSP00000421561   ENSP00000388465   ENSP00000361134   ENSP00000361148   ENSP00000430594  
     ENSP00000428321   ENSP00000430479   ENSP00000429643   ENSP00000409911   ENSP00000430829  
     ENSP00000429008   ENSP00000430002   ENSP00000230480   ENSP00000429592  
    Reactome Protein details: P15692
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant VEGFA Protein
    R&D Systems Recombinant & Natural Proteins for VEGFA (VEGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: VEGFA
    OriGene Protein Over-expression Lysate (see all 6): VEGFA
    OriGene Custom Protein Services for VEGFA 
    GenScript Purified and Recombinant Proteins for VEGFA
    Novus Biologicals VEGFA Proteins
    Novus Biologicals VEGFA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for VEGFA
    Uscn Proteins for VEGFA

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS14570917
    GO:0005604basement membrane ----
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IDA17082651


    VEGFA for ontologies           About GeneDecksing



    VEGFA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of VEGFA
    R&D Systems Antibodies for VEGFA (VEGF)
    OriGene Antibodies (see all 6): VEGFA
    OriGene Custom Antibody Services for VEGFA 
    GenScript Custom Superior Antibodies Services for VEGFA
    Novus Biologicals VEGFA Antibodies
    Abcam antibodies for VEGFA 
    Uscn Antibodies for VEGFA
    ThermoFisher Antibody for VEGFA

    Assay Products for VEGFA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for VEGFA (VEGF)         (see all)
    GenScript Custom Assay Services for VEGFA
    Enzo Life Sciences assays for VEGFA
    Uscn ELISAs and CLIAs for VEGFA

    Protein Domains /
    Families
    for VEGFA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VEGFA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000072 PD_growth_factor
     IPR023581 PD_growth_factor_CS

    Graphical View of Domain Structure for InterPro Entry P15692

    ProtoNet protein and cluster: P15692

    1 Blocks protein family: IPB000072 Platelet-derived growth factor (PDGF)

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Function
    for VEGFA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell
    proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the
    FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and
    VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate
    angiogenesis and inhibits tumor growth
    Induction: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic
    mutations

         Summary:  

    During embryonic development, VEGFA as signaling molecule is secreted from the following cells: Branchial Arch 2 Ectoderm Cells in Branchial Arch 2, Hypertrophic Chondrocytes in Cervical Vertebrae (see all 14).

    It affects the following cells: Angioblasts in Perineural capillary Plexus, Arterial endothelial cells in Paired Dorsal Aorta (see all 15).

    miRNA
    Products:            		miRTarBase miRNAs that target VEGFA:
    hsa-mir-34a (MIRT004513), hsa-mir-378 (MIRT004277), hsa-mir-17 (MIRT004271), hsa-mir-330-3p (MIRT004278), hsa-mir-140-5p (MIRT003812), hsa-mir-520h (MIRT004458), hsa-mir-20b (MIRT004451), hsa-mir-20a (MIRT004450), hsa-mir-125a-5p (MIRT004445), hsa-mir-107 (MIRT003814), hsa-mir-372 (MIRT004461), hsa-mir-383 (MIRT004443), hsa-mir-34b (MIRT004519), hsa-mir-302d (MIRT000722), hsa-mir-29b (MIRT003813), hsa-mir-150 (MIRT004272), hsa-mir-16 (MIRT003890), hsa-mir-504 (MIRT004457), hsa-mir-361-5p (MIRT004447), hsa-mir-126 (MIRT003428), hsa-mir-93 (MIRT004055), hsa-mir-205 (MIRT004518), hsa-mir-15a (MIRT004275), hsa-mir-134 (MIRT003811), hsa-mir-106a (MIRT004465), hsa-mir-373 (MIRT000721), hsa-mir-15b (MIRT004274), hsa-mir-106b (MIRT004466), hsa-mir-195 (MIRT004273), hsa-mir-147 (MIRT003810), hsa-mir-520g (MIRT004276)

    OriGene 3'-UTR Clone (see all 7): VEGFA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEGFA
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate VEGFA (see all 115):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-579 hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-520e hsa-miR-1321 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEGFA (see all 7)
    OriGene shRNA RFP: VEGFA
    OriGene siRNA: VEGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEGFA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VEGFA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFA (see all 27)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFA (see all 16)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 18): VEGFA (NM_001204384)
    Sino Biological Human cDNA Clone for VEGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for VEGFA
    Search LifeMap BioReagents cell lines for VEGFA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFA

    Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IDA14570917
    GO:0005125cytokine activity ISS--
    GO:0005161platelet-derived growth factor receptor binding IPI17470632
    GO:0005172vascular endothelial growth factor receptor binding IPI10471394
    GO:0005515protein binding IPI--


    VEGFA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VEGFA:
     Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-outs for VEGFA: Vegfatm1Gne Vegfatm1Dco Vegfatm2Pec Vegfatm1Pec
         15/25 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Vegfa) (see all 25):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    VEGFA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VEGFA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    		Transcription Receptor-mediated HIF regulation0.43
    		mTOR signaling pathway0.22
    		Transcription_Receptor-mediated HIF regulation0.43
    		Cell adhesion_Plasmin signaling0.07
    		Development_Leptin signaling via JAK/STAT and MAPK cascades0.25
    		Cell adhesion Plasmin signaling0.07
    		Development Leptin signaling via JAK/STAT and MAPK cascades0.25
    2Development VEGF signaling via VEGFR2 - generic cascades
    		Development VEGF signaling via VEGFR2 - generic cascades1.00
    		Development_VEGF signaling and activation0.75
    		Development VEGF signaling and activation0.75
    		Development_VEGF signaling via VEGFR2 - generic cascades0.51
    3Signaling by VEGF
    		Signaling by VEGF1.00
    		VEGF binds to VEGFR leading to receptor dimerization0.82
    		VEGF ligand-receptor interactions1.00
    4Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
    		Cellular responses to stress0.72
    		Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    		Cellular response to hypoxia0.72
    5Transcription_P53 signaling pathway
    		Transcription_P53 signaling pathway1.00
    		Transcription P53 signaling pathway0.98

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/10 EMD Millipore Pathways for VEGFA (see all 10)
        Development VEGF signaling and activation
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Cytoskeleton remodeling FAK signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Transcription Ligand-dependent activation of the ESR1/SP pathway


    5/10 GeneGo (Thomson Reuters) Pathways for VEGFA (see all 10)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/17 BioSystems Pathways for VEGFA (see all 17) 
        Angiogenesis
    Integrated Breast Cancer Pathway
    SIDS Susceptibility Pathways
    Heart Development
    Integrated Pancreatic Cancer Pathway

    5/13        Reactome Pathways for VEGFA (see all 13)
        Cellular response to hypoxia
    Hemostasis
    VEGF binds to VEGFR leading to receptor dimerization
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Response to elevated platelet cytosolic Ca2+

    2 PharmGKB Pathways for VEGFA
        Celecoxib Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/9         Kegg Pathways  (Kegg details for VEGFA) (see all 9):
        Cytokine-cytokine receptor interaction
    mTOR signaling pathway
    VEGF signaling pathway
    Focal adhesion
    Pathways in cancer


    VEGFA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VEGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for VEGFA (P156921, 2, 3 ENSP000003611254) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT1P179481, 3, ENSP000002823974EBI-1026643,EBI-1026718 I2D: score=5 STRING: ENSP00000282397
    NRP1O147862, 3, ENSP000002653714MINT-2834244 MINT-2834194 MINT-2834269 I2D: score=4 STRING: ENSP00000265371
    KDRP359681, 2, 3, ENSP000002639234EBI-1026691,EBI-1005487 MINT-2834174 I2D: score=5 STRING: ENSP00000263923
    SPARCP094863, ENSP000002310614I2D: score=4 STRING: ENSP00000231061
    GPC1P350523, ENSP000002640394I2D: score=3 STRING: ENSP00000264039
    About this table

    Gene Ontology (GO): 5/105 biological process terms (GO ID links to tree view) (see all 105):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18093989
    GO:0001525angiogenesis IDA11427521
    GO:0001541ovarian follicle development ISS--
    GO:0001568blood vessel development ----
    GO:0001569patterning of blood vessels ISS--


    VEGFA for ontologies           About GeneDecksing



    Drugs & Compounds
    for VEGFA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VEGFA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for VEGFA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 [204005-46-9]
    Ki 8751 Potent, selective VEGFR-2 inhibitor [228559-41-9]
    SU 4312Potent inhibitor of VEGFR tyrosine kinase[5812-07-7]
    ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2 [324077-30-7]
    ZM 306416 hydrochlorideInhibitor of VEGF receptor tyrosine kinase[690206-97-4]

    3 HMDB Compounds for VEGFA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    HeparinArteven (see all 17)9005-49-6--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    8 DrugBank Compounds for VEGFA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ranibizumab-- 347396-82-1target--17049020 18054637 17046701 15671306 15973626 18035187 18046235 17031284 19668384 16935211
    Carvedilol-- 72956-09-3targetother15942707 11378004 15732037 15071347
    Gliclazide1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea (see all 5)21187-98-4targetother/unknown17602961 17046555 14746574 12126787
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor21091776 17692905 16041398
    Minocycline-- 10118-90-8targetinhibitor16224178 15256478 11875741
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423 10592235
    Tris(Hydroxymethyl)Aminomethane-- --target--17139284 17016423 10592235
    BevacizumabantiVEGF (see all 3)216974-75-3target--15705858 11752352

    10/106 Novoseek chemical compound relationships for VEGFA gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 99.5 91016 9921991 (15), 10070308 (15), 15790460 (15), 15748443 (15) (see all 99)
    su5416 84.2 93 15474452 (5), 17169805 (4), 11156244 (3), 19420288 (3) (see all 51)
    pegaptanib 83.9 91 17509689 (3), 19668746 (3), 10548435 (2), 19734041 (2) (see all 54)
    matrigel 83.7 155 16447633 (2), 18080776 (2), 10634803 (2), 19616847 (2) (see all 99)
    ranibizumab 82.8 135 17714704 (5), 19643496 (4), 19674731 (3), 19553804 (3) (see all 66)
    sunitinib 82.2 97 17605814 (3), 19277038 (2), 17710208 (2), 18669461 (2) (see all 75)
    ptk787 80.7 50 10786682 (2), 19577260 (2), 15705616 (1), 15979888 (1) (see all 32)
    zd6474 80.1 52 19447868 (5), 19528456 (4), 12183421 (3), 19949019 (2) (see all 30)
    tyrosine 79.5 1237 19376222 (6), 9182576 (6), 10976958 (4), 9625748 (4) (see all 99)
    azd 2171 77.3 15 15899831 (1), 17592499 (1), 17906459 (1), 17634482 (1) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about VEGFA 

    Transcripts
    for VEGFA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VEGFA gene (18 alternative transcripts): 
    NM_001025366.2  NM_001025367.2  NM_001025368.2  NM_001025369.2  NM_001025370.2  NM_001033756.2  NM_001171622.1  NM_001171623.1  
    NM_001171624.1  NM_001171625.1  NM_001171626.1  NM_001171627.1  NM_001171628.1  NM_001171629.1  NM_001171630.1  NM_001204384.1  
    NM_001204385.1  NM_003376.5  

    Unigene Cluster for VEGFA:

    Vascular endothelial growth factor A
    Hs.73793  [show with all ESTs]
    Unigene Representative Sequence: NM_001025366
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000476772(uc003owb.3) ENST00000372067(uc003owd.3 uc010jyx.3 uc003owf.3 uc003owg.3 uc003owh.3 uc003owe.3 uc021yzu.1 uc003owj.3 uc003owi.3)
    ENST00000324450 ENST00000417285 ENST00000413642 ENST00000372055 ENST00000482630
    ENST00000425836 ENST00000372064 ENST00000372077 ENST00000519767 ENST00000520948
    ENST00000518538 ENST00000523873 ENST00000523950 ENST00000512683 ENST00000457104
    ENST00000518689

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 7): VEGFA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEGFA
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate VEGFA (see all 115):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-579 hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-520e hsa-miR-1321 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEGFA (see all 7)
    OriGene shRNA RFP: VEGFA
    OriGene siRNA: VEGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEGFA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFA (see all 27)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFA (see all 16)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 18): VEGFA (NM_001204384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFA 
    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEGFA

    Additional cDNA sequence: 

    AB021221.1 AB451322.1 AB451451.1 AF022375.1 AF024710.1 AF062645.1 AF091352.1 AF214570.1 
    AF430806.1 AF486837.1 AJ010438.1 AK056914.1 AK125666.1 AY047581.1 AY263145.1 AY500353.1 
    AY766116.1 BC011177.1 BC019867.2 BC058855.1 BC065522.1 DQ229900.1 M27281.1 M32977.1 
    S85192.1 X62568.1 

    22 DOTS entries:

    DT.101962506  DT.100817302  DT.95350198  DT.95339476  DT.100743047  DT.453994  DT.100817298  DT.121334558 
    DT.100817299  DT.101976085  DT.92450656  DT.92450657  DT.100817293  DT.102828056  DT.121334539  DT.40235175 
    DT.92450653  DT.100817297  DT.92450650  DT.92450651  DT.95182536  DT.95262131 

    24/416 AceView cDNA sequences (see all 416):

    CR592173 BQ880667 AY263145 AA923135 AA992216 CK299337 AW572374 CA866775 
    BM970555 BM053003 AI085744 CD617014 AA724008 CA307359 AF430806 BQ632326 
    BQ006682 AF062645 AW571763 AA358986 CA442374 BF343433 W52131 CK904368 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                          -     -                                         -     -                                 
    SP2:                          -     -                                               -                                 
    SP3:                          -     -                             -     -     -     -                                 
    SP4:                          -     -                                   -     -     -                                 
    SP5:                          -     -                             -     -     -     -           -                     


    ECgene alternative splicing isoforms for VEGFA

    Expression
    for VEGFA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VEGFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCAATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VEGFA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/69 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 69) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPericytesPericytes
    BoneAutopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    BoneAutopod Growth PlatePrehypertrophic ChondrocytesBone, Cartilage
    BoneAutopod Growth PlateTerminal ChondrocytesBone, Cartilage
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCaudal Endochondral BonesHypertrophic ChondrocytesBone, Cartilage
    BoneCaudal Endochondral BonesTerminal ChondrocytesBone, Cartilage
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneCervical VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneCervical VertebraePrehypertrophic ChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Mesenchymal Precursor Cells (STRO-3 selected) (Adult Stem / Progenitor Cell)Bone
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Mature follicles (In-vitro growth and ...)

    See VEGFA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VEGFA

    SOURCE GeneReport for Unigene cluster: Hs.73793

    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
    Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and
    isoform VEGF145 are not widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including VEGFA (see all 42): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFA

    Orthologs
    for VEGFA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFA gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves VEGFA1 vascular endothelial growth factor A 78.29(n)
    74.88(a)    		   395909  NM_205042.2  NP_990373.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VEGFA6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 1(226686337-226703857)
    African clawed frog
    (Xenopus laevis)    		 Amphibia vegf-A2 vascular endothelial growth factor 82.81(n)    AF008594.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii vegf2 vascular endothelial growth factor 75.7(n)   30682  AF016244.1 


    ENSEMBL Gene Tree for VEGFA (if available)
    TreeFam Gene Tree for VEGFA (if available) 

    Paralogs
    for VEGFA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VEGFA gene
    VEGFC2  PGF2  FIGF2  VEGFB2  
    4 SIMAP similar genes for VEGFA using alignment to 13 protein entries:     VEGFA_HUMAN (see all proteins):
    VEGF    VEGF41    PGF    VEGFB

    VEGFA for paralogs           About GeneDecksing



    Genomic Variants
    for VEGFA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 NCBI SNPs in VEGFA are shown (see all 346)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs122081521,2
    		--43456140(+) TATCCC/TGTTCA 18 -- us2k11Minor allele frequency- T:0.01NA 120
    rs770646981,2
    		--43456281(+) GGACTA/CGTGCA 18 -- us2k10--------
    rs343769961,2
    		C,F,--43456481(+) GGAAAT/CTGCTG 18 -- us2k16Minor allele frequency- C:0.02MN WA 522
    rs126641041,2
    		H--43456534(+) CTGTAG/TGCCAG 18 -- us2k10--------
    rs2010743851,2
    		C--43456578(+) ACTGGC/TCCCAC 18 -- us2k10--------
    rs351612941,2
    		F--43456625(+) TGGGGC/AAGCCT 18 -- us2k15Minor allele frequency- A:0.01MN 212
    rs362080491,2
    		C,F,--43456839(-) CTCAGC/ATCCCC 18 -- us2k11Minor allele frequency- A:0.11WA 118
    rs362080481,2
    		C,F,--43456989(-) GGCCTG/TCGTGA 18 -- us2k13Minor allele frequency- T:0.16WA 122
    rs362080471,2
    		C,--43457051(-) CCAACA/CCCAGA 18 -- us2k10--------
    rs362080501,2
    		C,--43457055(-) CCCCC-/CAACCC 18 -- us2k10--------

    HapMap Linkage Disequilibrium report for VEGFA (43737921 - 43754224 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VEGFA: --
    Human Gene Mutation Database (HGMD): VEGFA

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing VEGFA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEGFA
    DNA2.0 Custom Variant and Variant Library Synthesis for VEGFA

    Disorders / Diseases
    for VEGFA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VEGFA for disorders           About GeneDecksing

    OMIM gene information: 192240   
    OMIM disorders: 603933  
    UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
  • Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1)
    • [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of
    diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and
    diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is
    characterized by vascular permeability and increased tissue ischemia and angiogenesis

    20/524 diseases for VEGFA (see all 524):    About MalaCards
    diabetic retinopathy    poems syndrome    von hippel-lindau disease    crimean-congo hemorrhagic fever
    kuhnt-junius degeneration    twin-to-twin transfusion syndrome    retinal vein occlusion    central retinal vein occlusion
    progesterone-receptor positive breast cancer    rubeosis iridis    sturge-weber syndrome    growth hormone secreting pituitary adenoma
    twin twin transfusion syndrome    alpha 1-antitrypsin deficiency    estrogen-receptor negative breast cancer    estrogen-receptor positive breast cancer
    severe nonproliferative diabetic retinopathy    angioid streaks    shwachman-diamond syndrome    b-cell non-hodgkin lymphoma

    20/59 diseases from the University of Copenhagen DISEASES database for VEGFA (see all 59):
    Diabetic retinopathy     Age related macular degeneration     Kuhnt-Junius degeneration     Colorectal cancer
    Carcinoma     Retinopathy of prematurity     Lung cancer     Macular retinal edema
    Renal cell carcinoma     Malignant glioma     Breast cancer     Hypertension
    Blindness     Ovarian hyperstimulation syndrome     Heart disease     Retinal vein occlusion
    Keratitis     Ovarian cancer     Hepatocellular carcinoma     POEMS syndrome

    10/97 Novoseek disease relationships for VEGFA gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 92.9 1184 10406801 (4), 16179869 (4), 19639355 (4), 9815760 (4) (see all 99)
    tumors 88.1 9908 16222693 (9), 11176129 (9), 1940805 (9), 15699727 (8) (see all 99)
    metastasis 83.9 1955 15473929 (8), 12926153 (6), 10070308 (6), 17283532 (6) (see all 99)
    cancer 80.7 1954 9933044 (8), 12726933 (6), 19633424 (6), 10853032 (6) (see all 99)
    proliferative diabetic retinopathy 80.2 196 7943121 (4), 11935151 (4), 15767056 (3), 18053608 (3) (see all 95)
    diabetic retinopathy 79.8 354 19216096 (5), 19646547 (4), 11440280 (4), 11642376 (4) (see all 99)
    solid tumor 79.7 294 11734110 (3), 10811135 (3), 11297245 (2), 11776866 (2) (see all 99)
    retinal neovascularization 78 88 16936124 (4), 7479819 (3), 16785756 (3), 11740151 (2) (see all 43)
    choroidal neovascularization 76.2 124 10410552 (3), 10484206 (2), 15389527 (2), 18728623 (2) (see all 74)
    retinopathy 73.9 314 11437859 (4), 18382886 (4), 20169883 (4), 9046048 (4) (see all 99)

    Human Genome Epidemiology (HuGE) Navigator: VEGFA (439 documents)

    Export disorders for VEGFA gene to outside databases

    Publications
    for VEGFA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VEGFA gene, integrated from 9 sources (see all 8942):
    (articles sorted by number of sources associating them with VEGFA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding. (PubMed id 9351807)1, 2, 9 Muller Y.A.... de Vos A.M. (1997)
    2. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. (PubMed id 11978667)1, 2, 9 Awata T....Katayama S. (2002)
    3. Solution structure of the heparin-binding domain of vascular endothelial growth factor. (PubMed id 9634701)1, 2, 9 Fairbrother W.J....Starovasnik M.A. (1998)
    4. AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. (PubMed id 1567395)1, 2, 9 Weindel K.... Weich H.A. (1992)
    5. Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant. (PubMed id 10464055)1, 2, 9 Whittle C.J....Harper S.J. (1999)
    6. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. (PubMed id 9054410)1, 2, 9 Poltorak Z.... Neufeld G. (1997)
    7. Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. (PubMed id 16489009)1, 2 Dixelius J....Claesson-Welsh L. (2006)
    8. Nuclear localization of long-VEGF is associated with hypoxia and tumor angiogenesis. (PubMed id 15896327)1, 2 Rosenbaum-Dekel Y....Levi B.Z. (2005)
    9. Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences. (PubMed id 14764596)1, 2 Bornes S.... Touriol C. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for VEGFA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VEGFA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7422 HGNC: 12680 AceView: VEGF Ensembl:ENSG00000112715 euGenes: HUgn7422
    ECgene: VEGFA Kegg: 7422 H-InvDB: VEGFA

    Other Databases showing VEGFA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VEGFA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VEGFA Pharmacogenomics, SNPs, Pathways
    R&D Systems' cytokine mini-reviews: VEGFhttp://www.rndsystems.com/molecule_detail.aspx?m=2247
    Wikipedia http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
    SeattleSNPshttp://pga.gs.washington.edu/data/vegf/

    Intellectual Property
    for VEGFA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VEGFA gene:
    Search GeneIP for patents involving VEGFA

    Licensable Technologies for VEGFA gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for VEGFA gene

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    About This Section

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