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VEGFA Gene

protein-coding GIFtS: 63

GC06P043846

vascular endothelial growth factor A
(Previous name: vascular endothelial growth factor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VEGF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC70609 ^²
MVCD1 ^²
VEGF ^², ³
VEGF-A ^¹, ², ³
VPF ^¹, ², ³

Descriptions
Vascular permeability factor ^², ³
vascular endothelial growth factor ^¹
vascular endothelial growth factor A ^²
vascular endothelial growth factor isoform VEGF165 ^²

External Ids
HGNC: 12680¹
Entrez Gene: 7422²
UniProtKB: P15692³
Ensembl: ENSG00000112715⁷

Search outside databases for aliases for VEGFA gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VEGFA:

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often

found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically

acts on endothelial cells and has various effects, including mediating increased vascular

permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell

migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome,

also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative

and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding

either freely secreted or cell-associated isoforms, have been characterized. There is also

evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with

the first AUG, leading to additional isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692

Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces

endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces

permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan

sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to

VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and

inhibits tumor growth

Gene Wiki entry for VEGFA (Vascular_endothelial_growth_factor_A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12

VEGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P043846: (about GC identifiers)

Start:	43,845,926 bp from pter
End:	43,862,202 bp from pter
Size:	16,277 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692 (See protein sequence)

Recommended Name: Vascular endothelial growth factor A precursor

Size: 232 amino acids; 27042 Da

Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PlGF (By similarity)

Subcellular location: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic,

has heparin-binding properties and, although a signicant proportion remains cell-associated, most

is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound

avidly by heparin and the extracellular matrix, although it may be released as a soluble form by

heparin, heparinase or plasmin

PDB structures from and Proteopedia :

1BJ1 (3D)

1CZ8 (3D)

1FLT (3D)

1KAT (3D)

1KMX (3D)

1MJV (3D)

1MKG (3D)

1MKK (3D)

1QTY (3D)

1TZH (3D)

1TZI (3D)

1VGH (3D)

1VPF (3D)

1VPP (3D)

2FJG (3D)

2FJH (3D)

2QR0 (3D)

2VGH (3D)

2VPF (3D)

3BDY (3D)

Secondary accessions: O60720 O75875 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5 Q9H1W8 Q9H1W9

Q9UH58 Q9UL23

Alternative splicing: 10 isoforms: P15692-1 P15692-2 P15692-3 P15692-4 P15692-5 P15692-6 P15692-7 P15692-8

P15692-9 P15692-10

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (7 alternative transcripts):

NP_001020537.2 NP_001020538.2 NP_001020539.2 NP_001020540.2 NP_001020541.2 NP_001028928.1 NP_003367.4

ENSEMBL proteins:

ENSP00000361134 ENSP00000361137 ENSP00000361125 ENSP00000317598 ENSP00000361148 ENSP00000230480

Human Recombinant Proteins

	Invitrogen human recombinant proteins for VEGFA
	Millipore Purified and/or Recombinant VEGFA Protein
	Sigma-Aldrich Proteins for VEGFA
	R&D Systems Recombinant & Natural Proteins for VEGFA (VEGF)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VEGF, VEGF 165B, VEGF 164, VEGFA, VEGF 121, VEGF 165A)
	Human Recombinant Proteins from Abnova (VEGF)

OriGene Purified Recombinant Human Protein: VEGFA

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	NAS	14570917
GO:0005615	extracellular space	IDA	16490744
GO:0009986	cell surface	IDA	17470632
GO:0016020	membrane	IEA	--

About this table

Antibodies for VEGFA:

	Invitrogen Antibodies for VEGFA
	Millipore Mono- and Polyclonal Antibodies for the study of VEGFA
	Sigma-Aldrich Antibodies for VEGFA
	R&D Systems Antibodies for VEGFA (VEGF)
	Antibodies from Abcam (VEGF, VEGF 165B, VEGF 164, VEGFA, VEGF 121, VEGF 165A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VEGF)
	Novus Biologicals Antibodies for VEGFA

Assays for VEGFA:

	Invitrogen Assays for VEGFA
	Millipore Kits and Assays for the Analysis of VEGFA
	R&D Systems Flow Cytometry Kits for VEGFA (VEGF) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15692

ProtoNet protein and cluster: P15692

1 Blocks protein family: IPB000072 Platelet-derived growth factor (PDGF)

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VEGFA)
		Millipore RNAi Products for the Analysis of VEGFA Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001033756

Applied Biosystems Silencer® siRNAs for VEGFA

Sigma-Aldrich siRNA for VEGFA

Sigma-Aldrich shRNA Panels and shRNA for VEGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_001025366
Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_001025366
untagged cDNA clones in CMV expression vector (see all 8): AF022375

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001025366

UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692

Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces

endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces

permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan

sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to

VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and

inhibits tumor growth

Induction: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia,

hypoglycemia and oncogenic mutations

15/25 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Vegfa) (see all 25 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IDA	14570917
GO:0005125	cytokine activity	ISS	--
GO:0005161	platelet-derived growth factor receptor binding	IPI	17470632
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IDA	15001987

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for VEGFA (Your Favorite Gene powered by Ingenuity) (see all 15 )

Nitric Oxide Signaling in the Cardiovascular System
Relaxin Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
IL-8 Signaling
Hypoxia Signaling in the Cardiovascular System

GeneDecks VEGFA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for VEGFA

2 Interacting proteins for VEGFA (P15692^{1, 2}) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
NRP1 O14786¹^,² EBI-1026643, EBI-1187100 MINT-2834244 MINT-2834194 MINT-2834269 EBI-1026643, EBI-1187100 MINT-2834244 MINT-2834194 MINT-2834269
NRP1 O14786¹^,² EBI-1026643, EBI-1187100 MINT-2834244 MINT-2834194 MINT-2834269 EBI-1026643, EBI-1187100 MINT-2834244 MINT-2834194 MINT-2834269
KDR P35968² MINT-2834174
About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 11427521
GO:0001570 vasculogenesis TAS 15015550
GO:0001666 response to hypoxia IDA 16490744
GO:0001938 positive regulation of endothelial cell proliferation ISS --
GO:0002687 positive regulation of leukocyte migration TAS 1312256
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for VEGFA:

Inhibitor

Compounds for VEGFA available from Tocris Bioscience

Compound	Action	CAS number
SU 5416	VEGFR inhibitor. Also inhibits c-kit, Ret, MET and FLT3	[204005-46-9]
Ki 8751	Potent, selective VEGFR-2 inhibitor	[228559-41-9]
SU 4312	Potent inhibitor of VEGFR tyrosine kinase	[5812-07-7]
ZM 323881 hydrochloride	Potent, selective inhibitor of VEGFR-2	[324077-30-7]
ZM 306416 hydrochloride	Inhibitor of VEGF receptor tyrosine kinase	[690206-97-4]

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7 Novoseek chemical compound relationships for VEGFA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	83.05	132	16447633 (2), 18080776 (2), 10634803 (2), 11519827 (2) (see all 88)
zd6474	80.14	38	19447868 (5), 12183421 (3), 18379357 (1), 18694994 (1) (see all 23)
tyrosine	78.89	1108	19376222 (6), 9182576 (6), 10976958 (4), 9625748 (4) (see all 99)
azd 2171	77.74	14	15899831 (1), 17592499 (1), 17906459 (1), 17634482 (1) (see all 11)
su6668	72.15	16	11532618 (1), 11912143 (1), 14611919 (1), 15958585 (1) (see all 11)
axitinib	69.82	7	16860997 (1), 17657252 (1), 18516765 (1), 16425985 (1) (see all 7)
temsirolimus	61.54	4	16740688 (2), 17619763 (1), 18774471 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VEGFA)
		Millipore RNAi Products for the Analysis of VEGFA Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001033756

Sigma-Aldrich siRNA for VEGFA

Sigma-Aldrich shRNA Panels and shRNA for VEGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_003376

REFSEQ mRNAs for VEGFA gene (7 alternative transcripts):

NM_001025366.1 NM_001025367.1 NM_001025368.1 NM_001025369.1 NM_001025370.1 NM_001033756.1 NM_003376.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_003376

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_001025366
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_001025366
                                 untagged cDNA clones in CMV expression vector (see all 8): AF022375

Additional cDNA sequence:

AB021221.1 AB451322.1 AB451451.1 AF022375.1 AF024710.1 AF062645.1 AF091352.1 AF214570.1

AF430806.1 AF486837.1 AJ010438.1 AK056914.1 AK125666.1 AY047581.1 AY263145.1 AY500353.1

AY766116.1 BC011177.1 BC019867.2 BC058855.1 BC065522.1 CR592173.1 CR614384.1 DQ229900.1

M27281.1 M32977.1 S85192.1 X62568.1

22 DOTS entries:

DT.101962506 DT.100817302 DT.95350198 DT.100743047 DT.95339476 DT.453994 DT.92450656 DT.101976085

DT.121334558 DT.100817298 DT.100817299 DT.92450657 DT.100817293 DT.102828056 DT.121334539 DT.40235175

DT.92450653 DT.100817297 DT.92450651 DT.92450650 DT.95182536 DT.95262131

24/416 AceView cDNA sequences (see all 416 ):

CB132368 AA514977 AA923135 BF343433 AW168482 BG054972 BF340289 AI298922

BM689711 CA442374 AI683745 AA328734 CK904368 AW003436 BG055994 BM757090

CA423131 AA350839 BQ880667 W96086 CA435189 BE350528 AF486837 CA866775

highest scoring ESTs for VEGFA:

AF022375 AF024710 AA045836 AA045948 AA045970 AA047488 AA126903 AA128079 AA292211 AA297069

Unigene Cluster for VEGFA:

Vascular endothelial growth factor A

Hs.73793 [show with all ESTs]

Unigene Representative Sequence: NM_001025366

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	·	9d
SP1:									-		-														-		-
SP2:									-		-																-
SP3:									-		-										-		-		-		-
SP4:									-		-												-		-		-
SP5:									-		-										-		-		-		-				-

About this scheme

ECgene alternative splicing isoforms for VEGFA

6 Ensembl transcripts including schematic representations:

ENST00000372064 ENST00000372067 ENST00000372055 ENST00000324450 ENST00000372077 ENST00000230480

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VEGFA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VEGFA

¹ / ² / ³

12 probe-sets matching VEGFA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1953_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.06	AF024710	1.00	1.00	1.00	1
73146_at²^{, 3}	U95-E	1	1.00	1.00	0.98	1.27	AW024572	0.80	1.00	0.91	1
36100_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.01	AF022375	1.00	1.00	1.00	1
36101_s_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.67	M63978	0.20	1.00	0.72	1
212171_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	H95344	0.80	1.00	0.91	1
211527_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M27281	0.80	1.00	0.91	1
210512_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF022375	1.00	1.00	1.00	1
210513_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF091352	0.60	1.00	0.82	1
212171_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211527_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210512_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210513_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VEGFA for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTCCAATCT

SOURCE GeneReport for Unigene cluster: Hs.73793
UniProtKB/Swiss-Prot: VEGFA_HUMAN, P15692
Tissue specificity: The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the
VEGF206 and VEGF-145 are uncommon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VEGFA gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VEGFA¹	--	vascular endothelial growth factor A	95.02(n) 96.73(a)	403802 NM_001003175.1 NP_001003175.1
cow (Bos taurus)	VEGFA¹	--	vascular endothelial growth factor A	95.26(n) 94.74(a)	281572 NM_174216.1 NP_776641.1
rat (Rattus norvegicus)	Vegfa¹	--	vascular endothelial growth factor A	90.81(n) 90.65(a)	83785 NM_031836.1 NP_114024.1
mouse (Mus musculus)	Vegfa^{1, 5}	17 (24.20 cM)⁵	vascular endothelial growth factor A^{1, 5}	90.5(n)¹ 90.65(a)¹	22339¹ NM_001025250.2¹ NP_001020421.1¹ AA959550⁵ AB086118⁵ (see all 31)
chicken (Gallus gallus)	VEGFA¹	--	vascular endothelial growth factor A	78.29(n) 74.88(a)	395909 NM_205042.1 NP_990373.1

About this table Species with no ortholog for VEGFA

ENSEMBL Gene Tree for VEGFA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VEGFA gene

VEGFC² PGF² FIGF² VEGFB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/150 NCBI SNPs in VEGFA are shown (see all 150 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs833061^1,2	A,C,F,H	43845464(+)	`GAGGGT/CGTTGG`	7	--	ng5¹		7		MN EU EA WA	692
	rs3025040^1,2	A,C,F,H	43861029(+)	`GACACC/TGGCTC`	7	--	ut3¹ ese³		13		NS EU EA WA NA	1202
	rs699947^1,2	A,C,F,H	43844367(+)	`TGGCAC/AGATCT`	7	--	ng5¹		13		EA MN EU WA CSAM	1370
	rs10434^1,2	A,C,F,H	43861190(+)	`AGGAGG/ACCACT`	7	--	ut3¹ ese³		13		MN NS NA EA EU WA	1274
	rs3025039^1,2	A,C,F	43860514(+)	`CAGCAC/TGGTCC`	7	--	ut3¹ ese³		14		NS MN CSAM EA NA	1206
	rs2010963^1,2	A,C,F	43846328(+)	`GAAAGG/CGACAG`	7	--	ut5¹ ese³		13		MN NA EA CSAM	1124
	rs1005230^1,2	A,C,F	43844474(+)	`CCAGCC/TAGGAA`	7	--	ng5¹		6		MN CSAM EA	396
	rs3025053^1,2	C,F	43861303(+)	`CTGGGG/ATGCAG`	7	--	ut3¹		9		NS NA	792
	rs1570360^1,2	A,C	43845808(+)	`GTGGAA/GGGGCT`	7	--	ng5¹		0	--	--	--	--
--	rs13207351^1,2	A,C	43845772(+)	`CACTGG/AGCGTC`	7	--	ng5¹		1		MN	94

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HapMap Linkage Disequilibrium images for VEGFA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 192240

10/97 Novoseek disease relationships for VEGFA gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	92.81	1057	10406801 (4), 16179869 (4), 12452033 (4), 9815760 (4) (see all 99)
tumors	87.66	8944	16222693 (9), 11176129 (9), 1940805 (9), 15699727 (8) (see all 99)
metastasis	83.39	1795	15473929 (8), 12926153 (6), 10070308 (6), 17283532 (6) (see all 99)
proliferative diabetic retinopathy	79.61	171	7943121 (4), 11935151 (4), 15767056 (3), 18053608 (3) (see all 84)
solid tumor	79.41	277	11734110 (3), 10811135 (3), 11297245 (2), 11776866 (2) (see all 99)
cancer	79.35	1709	9933044 (8), 12726933 (6), 10100697 (6), 10853032 (6) (see all 99)
diabetic retinopathy	79.07	307	11440280 (4), 11642376 (4), 11978667 (4), 17725274 (3) (see all 99)
retinal neovascularization	77.80	82	16936124 (4), 7479819 (3), 16785756 (3), 11740151 (2) (see all 41)
choroidal neovascularization	73.77	108	10410552 (3), 10484206 (2), 15389527 (2), 10967078 (2) (see all 61)
poems syndrome	72.67	93	15609708 (4), 9430997 (4), 10377815 (3), 9771661 (3) (see all 50)

About this table

Human Gene Mutation Database: VEGFA
Human Genome Epidemiology Navigator: VEGFA (244 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/6379 PubMed articles for VEGFA gene (see all 6379 ):

The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding. (PubMed id 9351807)^{1, 3, 4} Muller Y.A.... de Vos A.M. (1997)
AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. (PubMed id 1567395)^{1, 3, 4} Weindel K.... Weich H.A. (1992)
Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant. (PubMed id 10464055)^{1, 3, 4} Whittle C.J....Harper S.J. (1999)
Solution structure of the heparin-binding domain of vascular endothelial growth factor. (PubMed id 9634701)^{1, 3, 4} Fairbrother W.J....Starovasnik M.A. (1998)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. (PubMed id 12124351)^{3, 4} Bates D.O.... Harper S.J. (2002)
Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor. (PubMed id 11427521)^{3, 4} Murphy J.F. and Fitzgerald D.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7422	HGNC: 12680	AceView: VEGF	Ensembl:ENSG00000112715	euGenes: HUgn7422
ECgene: VEGFA	H-InvDB: VEGFA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
R&D Systems' cytokine mini-reviews: VEGF	http://www.rndsystems.com/molecule_detail.aspx?m=2247
Wikipedia	http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
SeattleSNPs	http://pga.gs.washington.edu/data/vegf/

Licensable Technologies for VEGFA
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Licensable Technologies for VEGFA gene:

Weizmann Institute:

Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VEGFA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VEGFA-related products

	Millipore Custom Antibody & Bulk Services
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VEGFA Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VEGFA

Summaries
for VEGFA

Genomic Location
for VEGFA

Proteins
for VEGFA

Protein Domains/
Families
for VEGFA

Gene Function
for VEGFA

Pathways & Interactions
for VEGFA

Drugs & Compounds
for VEGFA

Transcripts
for VEGFA

Expression
for VEGFA

Orthologs
for VEGFA

Paralogs
for VEGFA

SNPs/Variants
for VEGFA

Disorders & Mutations
for VEGFA

Medical News
for VEGFA

Publications
for VEGFA

Search for VEGFA

Genome Databases showing VEGFA

Other Databases showing VEGFA

Specialized Databases showing VEGFA

Licensable Technologies
for VEGFA

Services
for VEGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VEGFA Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VEGFA

Summariesfor VEGFA

Genomic Locationfor VEGFA

Proteinsfor VEGFA

Protein Domains/Familiesfor VEGFA

Gene Functionfor VEGFA

Pathways & Interactionsfor VEGFA

Drugs & Compoundsfor VEGFA

Transcriptsfor VEGFA

Expression for VEGFA

Orthologsfor VEGFA

Paralogsfor VEGFA

SNPs/Variantsfor VEGFA

Disorders & Mutationsfor VEGFA

Medical Newsfor VEGFA

Publicationsfor VEGFA

Search for VEGFA

Genome Databases showing VEGFA

Other Databases showing VEGFA

Specialized Databases showing VEGFA

Licensable Technologiesfor VEGFA

Servicesfor VEGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VEGFA

Summaries
for VEGFA

Genomic Location
for VEGFA

Proteins
for VEGFA

Protein Domains/
Families
for VEGFA

Gene Function
for VEGFA

Pathways & Interactions
for VEGFA

Drugs & Compounds
for VEGFA

Transcripts
for VEGFA

Expression
for VEGFA

Orthologs
for VEGFA

Paralogs
for VEGFA

SNPs/Variants
for VEGFA

Disorders & Mutations
for VEGFA

Medical News
for VEGFA

Publications
for VEGFA

Licensable Technologies
for VEGFA

Services
for VEGFA