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Aliases for VDAC3 Gene

Aliases for VDAC3 Gene

  • Voltage-Dependent Anion Channel 3 2 3
  • Outer Mitochondrial Membrane Protein Porin 3 3 4
  • VDAC-3 3 4
  • Voltage-Dependent Anion-Selective Channel Protein 3 3
  • HD-VDAC3 3
  • HVDAC3 4

External Ids for VDAC3 Gene

Previous GeneCards Identifiers for VDAC3 Gene

  • GC08P041661
  • GC08P042274
  • GC08P041990
  • GC08P042266
  • GC08P040772
  • GC08P042249

Summaries for VDAC3 Gene

Entrez Gene Summary for VDAC3 Gene

  • This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VDAC3 Gene

VDAC3 (Voltage-Dependent Anion Channel 3) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC1.

UniProtKB/Swiss-Prot for VDAC3 Gene

  • Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene Wiki entry for VDAC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC3 Gene

Genomics for VDAC3 Gene

Regulatory Elements for VDAC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VDAC3 Gene

Start:
42,391,624 bp from pter
End:
42,405,937 bp from pter
Size:
14,314 bases
Orientation:
Plus strand

Genomic View for VDAC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VDAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC3 Gene

Proteins for VDAC3 Gene

  • Protein details for VDAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y277-VDAC3_HUMAN
    Recommended name:
    Voltage-dependent anion-selective channel protein 3
    Protein Accession:
    Q9Y277
    Secondary Accessions:
    • Q9UIS0

    Protein attributes for VDAC3 Gene

    Size:
    283 amino acids
    Molecular mass:
    30659 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VDAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VDAC3 Gene

Proteomics data for VDAC3 Gene at MOPED

Post-translational modifications for VDAC3 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys20 and Lys266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VDAC3 Gene

Domains for VDAC3 Gene

Gene Families for VDAC3 Gene

HGNC:
  • VDAC :Voltage-dependent anion channels

Protein Domains for VDAC3 Gene

Suggested Antigen Peptide Sequences for VDAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y277

UniProtKB/Swiss-Prot:

VDAC3_HUMAN :
  • Q9Y277
Domain:
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
Family:
  • Belongs to the eukaryotic mitochondrial porin family.
genes like me logo Genes that share domains with VDAC3: view

Function for VDAC3 Gene

Molecular function for VDAC3 Gene

GENATLAS Biochemistry: voltage-dependent anion channel 3,mitochondrial outer membrane,porin 3,allowing diffusion of small hydrophilic molecules,homolog to murine Vdac3,previously mapped to chromosome 12
UniProtKB/Swiss-Prot Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene Ontology (GO) - Molecular Function for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0008308 voltage-gated anion channel activity TAS 9781040
GO:0015288 porin activity IEA --
genes like me logo Genes that share ontologies with VDAC3: view
genes like me logo Genes that share phenotypes with VDAC3: view

Animal Models for VDAC3 Gene

MGI Knock Outs for VDAC3:

Animal Model Products

CRISPR Products

miRNA for VDAC3 Gene

miRTarBase miRNAs that target VDAC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VDAC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VDAC3 Gene

Localization for VDAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC3 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VDAC3 Gene COMPARTMENTS Subcellular localization image for VDAC3 gene
Compartment Confidence
mitochondrion 5
cytosol 3

Gene Ontology (GO) - Cellular Components for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0046930 pore complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VDAC3: view

Pathways for VDAC3 Gene

genes like me logo Genes that share pathways with VDAC3: view

Pathways by source for VDAC3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006820 anion transport IEA --
GO:0015853 adenine transport TAS 9781040
GO:0044070 regulation of anion transport --
GO:0055085 transmembrane transport IEA --
GO:1902017 regulation of cilium assembly IEA --
genes like me logo Genes that share ontologies with VDAC3: view

Compounds for VDAC3 Gene

(1) Drugbank Compounds for VDAC3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dihydroxyaluminium
13682-92-3 target inhibitor
genes like me logo Genes that share compounds with VDAC3: view

Transcripts for VDAC3 Gene

Unigene Clusters for VDAC3 Gene

Voltage-dependent anion channel 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VDAC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC3 Gene

No ASD Table

Relevant External Links for VDAC3 Gene

GeneLoc Exon Structure for
VDAC3
ECgene alternative splicing isoforms for
VDAC3

Expression for VDAC3 Gene

mRNA expression in normal human tissues for VDAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VDAC3 Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VDAC3 Gene

SOURCE GeneReport for Unigene cluster for VDAC3 Gene Hs.699301

mRNA Expression by UniProt/SwissProt for VDAC3 Gene

Q9Y277-VDAC3_HUMAN
Tissue specificity: Widely expressed. Highest in testis
genes like me logo Genes that share expressions with VDAC3: view

In Situ Assay Products

Orthologs for VDAC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VDAC3 35
  • 99.76 (n)
  • 100 (a)
VDAC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 76 (a)
OneToMany
VDAC3 35
  • 93.64 (n)
  • 98.23 (a)
VDAC5P 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia VDAC3 35
  • 94.58 (n)
  • 98.59 (a)
VDAC3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vdac3 35
  • 91.76 (n)
  • 98.23 (a)
Vdac3 16
Vdac3 36
  • 98 (a)
OneToMany
Vdac3-ps1 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia VDAC3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vdac3 35
  • 90.69 (n)
  • 95.76 (a)
chicken
(Gallus gallus)
Aves VDAC3 35
  • 77.27 (n)
  • 81.63 (a)
VDAC3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VDAC3 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2509 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5756 35
vdac3 35
  • 71.61 (n)
  • 78.09 (a)
zebrafish
(Danio rerio)
Actinopterygii vdac3 35
  • 69.27 (n)
  • 74.47 (a)
vdac3 36
  • 66 (a)
OneToMany
VDAC3 (2 of 3) 36
  • 72 (a)
OneToMany
VDAC3 (3 of 3) 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17139 36
  • 18 (a)
ManyToMany
CG17140 36
  • 17 (a)
ManyToMany
porin 36
  • 58 (a)
ManyToMany
Porin2 36
  • 35 (a)
ManyToMany
porin 37
  • 58 (a)
CG17137 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea vdac-1 36
  • 39 (a)
OneToMany
R05G6.7 37
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 36
  • 27 (a)
ManyToMany
POR1 38
POR2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 36
  • 54 (a)
OneToMany
Species with no ortholog for VDAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC3 Gene

ENSEMBL:
Gene Tree for VDAC3 (if available)
TreeFam:
Gene Tree for VDAC3 (if available)

Paralogs for VDAC3 Gene

Paralogs for VDAC3 Gene

Selected SIMAP similar genes for VDAC3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for VDAC3 Gene

genes like me logo Genes that share paralogs with VDAC3: view

Variants for VDAC3 Gene

Sequence variations from dbSNP and Humsavar for VDAC3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6773 -- 42,405,639(+) GGAGA(C/T)GCTTG utr-variant-3-prime
rs1015734 -- 42,396,588(+) TTCCA(A/G)AATTT intron-variant
rs1802170 -- 42,405,642(+) GATGC(A/T)TGAAG utr-variant-3-prime
rs2272616 -- 42,391,729(+) GGTGC(C/T)GGCTT upstream-variant-2KB, utr-variant-5-prime
rs2976241 -- 42,403,932(+) TTCTA(G/T)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC3 Gene

Variant ID Type Subtype PubMed ID
nsv831301 CNV Loss 17160897

Relevant External Links for VDAC3 Gene

HapMap Linkage Disequilibrium report
VDAC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VDAC3 Gene

Disorders for VDAC3 Gene

Relevant External Links for VDAC3

Genetic Association Database (GAD)
VDAC3
Human Genome Epidemiology (HuGE) Navigator
VDAC3
genes like me logo Genes that share disorders with VDAC3: view

No data available for UniProtKB/Swiss-Prot for VDAC3 Gene

Publications for VDAC3 Gene

  1. The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo. (PMID: 10833333) Decker W.K. … Craigen W.J. (Mol. Genet. Metab. 2000) 3 4 23
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  3. Isolation of a novel human voltage-dependent anion channel gene. (PMID: 9781040) Rahmani Z. … Siddiqui A. (Eur. J. Hum. Genet. 1998) 2 3 4
  4. Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis. (PMID: 10501981) Decker W.K. … Craigen W.J. (Mamm. Genome 1999) 3 4
  5. The murine voltage-dependent anion channel gene family. Conserved structure and function. (PMID: 9228078) Sampson M.J. … Craigen W.J. (J. Biol. Chem. 1997) 3 23

Products for VDAC3 Gene

Sources for VDAC3 Gene

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