Aliases for VDAC3 Gene
External Ids for VDAC3 Gene
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for VDAC3 Gene
VDAC3 (Voltage-Dependent Anion Channel 3) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC1.
UniProtKB/Swiss-Prot for VDAC3 Gene
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.