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Aliases for VDAC3 Gene

Aliases for VDAC3 Gene

  • Voltage Dependent Anion Channel 3 2 3
  • Outer Mitochondrial Membrane Protein Porin 3 3 4
  • Voltage-Dependent Anion Channel 3 3 5
  • VDAC-3 3 4
  • HD-VDAC3 3
  • HVDAC3 4

External Ids for VDAC3 Gene

Previous GeneCards Identifiers for VDAC3 Gene

  • GC08P041661
  • GC08P042274
  • GC08P041990
  • GC08P042266
  • GC08P040772
  • GC08P042249

Summaries for VDAC3 Gene

Entrez Gene Summary for VDAC3 Gene

  • This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VDAC3 Gene

VDAC3 (Voltage Dependent Anion Channel 3) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Calcium signaling pathway. GO annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC1.

UniProtKB/Swiss-Prot for VDAC3 Gene

  • Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene Wiki entry for VDAC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC3 Gene

Genomics for VDAC3 Gene

Regulatory Elements for VDAC3 Gene

Enhancers for VDAC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VDAC3 on UCSC Golden Path with GeneCards custom track

Promoters for VDAC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VDAC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VDAC3 Gene

42,391,624 bp from pter
42,405,937 bp from pter
14,314 bases
Plus strand

Genomic View for VDAC3 Gene

Genes around VDAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VDAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VDAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC3 Gene

Proteins for VDAC3 Gene

  • Protein details for VDAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Voltage-dependent anion-selective channel protein 3
    Protein Accession:
    Secondary Accessions:
    • Q9UIS0

    Protein attributes for VDAC3 Gene

    283 amino acids
    Molecular mass:
    30659 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VDAC3 Gene


neXtProt entry for VDAC3 Gene

Proteomics data for VDAC3 Gene at MOPED

Post-translational modifications for VDAC3 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 20, Lys 53, and Lys 110
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VDAC3 Gene

Domains & Families for VDAC3 Gene

Gene Families for VDAC3 Gene

Protein Domains for VDAC3 Gene

Suggested Antigen Peptide Sequences for VDAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Belongs to the eukaryotic mitochondrial porin family.
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Belongs to the eukaryotic mitochondrial porin family.
genes like me logo Genes that share domains with VDAC3: view

Function for VDAC3 Gene

Molecular function for VDAC3 Gene

GENATLAS Biochemistry:
voltage-dependent anion channel 3,mitochondrial outer membrane,porin 3,allowing diffusion of small hydrophilic molecules,homolog to murine Vdac3,previously mapped to chromosome 12
UniProtKB/Swiss-Prot Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
genes like me logo Genes that share phenotypes with VDAC3: view

Animal Models for VDAC3 Gene

MGI Knock Outs for VDAC3:

Animal Model Products

miRNA for VDAC3 Gene

miRTarBase miRNAs that target VDAC3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VDAC3 Gene

Localization for VDAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC3 Gene

Mitochondrion outer membrane.

Subcellular locations from

Jensen Localization Image for VDAC3 Gene COMPARTMENTS Subcellular localization image for VDAC3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for VDAC3 Gene

Pathways & Interactions for VDAC3 Gene

genes like me logo Genes that share pathways with VDAC3: view

Pathways by source for VDAC3 Gene

Gene Ontology (GO) - Biological Process for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with VDAC3: view

No data available for SIGNOR curated interactions for VDAC3 Gene

Drugs & Compounds for VDAC3 Gene

(4) Drugs for VDAC3 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroxyaluminium Approved Pharma Target, inhibitor 0
PRLX 93936 Investigational Pharma Target 0
Erastin Pharma 0

(1) ApexBio Compounds for VDAC3 Gene

Compound Action Cas Number
Erastin 571203-78-6
genes like me logo Genes that share compounds with VDAC3: view

Transcripts for VDAC3 Gene

Unigene Clusters for VDAC3 Gene

Voltage-dependent anion channel 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC3 Gene

No ASD Table

Relevant External Links for VDAC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VDAC3 Gene

mRNA expression in normal human tissues for VDAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VDAC3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for VDAC3 Gene

This gene is overexpressed in Nasal epithelium (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VDAC3 Gene

SOURCE GeneReport for Unigene cluster for VDAC3 Gene Hs.699301

mRNA Expression by UniProt/SwissProt for VDAC3 Gene

Tissue specificity: Widely expressed. Highest in testis.
genes like me logo Genes that share expression patterns with VDAC3: view

Protein tissue co-expression partners for VDAC3 Gene

- Elite partner

Primer Products

Orthologs for VDAC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VDAC3 35
  • 93.64 (n)
  • 98.23 (a)
-- 36
  • 76 (a)
  • 98 (a)
(Canis familiaris)
Mammalia VDAC3 35
  • 94.58 (n)
  • 98.59 (a)
VDAC3 36
  • 96 (a)
(Mus musculus)
Mammalia Vdac3 35
  • 91.76 (n)
  • 98.23 (a)
Vdac3 16
Vdac3 36
  • 98 (a)
Vdac3-ps1 36
  • 98 (a)
(Pan troglodytes)
Mammalia VDAC3 35
  • 99.76 (n)
  • 100 (a)
VDAC3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Vdac3 35
  • 90.69 (n)
  • 95.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
-- 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia VDAC3 36
  • 86 (a)
(Gallus gallus)
Aves VDAC3 35
  • 77.27 (n)
  • 81.63 (a)
VDAC3 36
  • 81 (a)
(Anolis carolinensis)
Reptilia VDAC3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5756 35
vdac3 35
  • 71.61 (n)
  • 78.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2509 35
(Danio rerio)
Actinopterygii vdac3 35
  • 69.27 (n)
  • 74.47 (a)
vdac3 36
  • 66 (a)
VDAC3 (2 of 3) 36
  • 72 (a)
VDAC3 (3 of 3) 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17137 37
  • 35 (a)
porin 37
  • 58 (a)
CG17139 36
  • 18 (a)
CG17140 36
  • 17 (a)
porin 36
  • 58 (a)
Porin2 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea R05G6.7 37
  • 39 (a)
vdac-1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 36
  • 27 (a)
POR2 36
  • 20 (a)
POR1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 36
  • 54 (a)
Species with no ortholog for VDAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC3 Gene

Gene Tree for VDAC3 (if available)
Gene Tree for VDAC3 (if available)

Paralogs for VDAC3 Gene

Paralogs for VDAC3 Gene

(2) SIMAP similar genes for VDAC3 Gene using alignment to 8 proteins: Pseudogenes for VDAC3 Gene

genes like me logo Genes that share paralogs with VDAC3: view

Variants for VDAC3 Gene

Sequence variations from dbSNP and Humsavar for VDAC3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7831370 -- 42,401,557(+) TATCA(C/T)TTGAA intron-variant
rs7841841 -- 42,396,862(+) TTTAA(C/T)GTAGA intron-variant
rs7842860 -- 42,401,229(+) gtctc(A/G)ctctg intron-variant
rs8180982 -- 42,400,400(+) AATTT(C/T)TTAAG intron-variant
rs10089139 -- 42,400,136(+) ATGGA(A/G)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC3 Gene

Variant ID Type Subtype PubMed ID
nsv831301 CNV Loss 17160897

Variation tolerance for VDAC3 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VDAC3 Gene

Disorders for VDAC3 Gene

Relevant External Links for VDAC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VDAC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VDAC3 Gene

Publications for VDAC3 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? (PMID: 17683036) LefiA"vre L. … Barratt C.L. (Proteomics 2007) 3 23
  3. The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo. (PMID: 10833333) Decker W.K. … Craigen W.J. (Mol. Genet. Metab. 2000) 3 23
  4. Isolation of a novel human voltage-dependent anion channel gene. (PMID: 9781040) Rahmani Z. … Siddiqui A. (Eur. J. Hum. Genet. 1998) 2 3
  5. The murine voltage-dependent anion channel gene family. Conserved structure and function. (PMID: 9228078) Sampson M.J. … Craigen W.J. (J. Biol. Chem. 1997) 3 23

Products for VDAC3 Gene

Sources for VDAC3 Gene