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Aliases & Descriptions for VDAC3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases HD-VDAC3 1 , 2 VDAC-3 3 hVDAC3 3
Descriptions Outer mitochondrial membrane protein porin 3 3 voltage-dependent anion channel 3 2
Search outside databases for aliases for VDAC3 genePrevious GC identifers: GC08P041661 GC08P042274 GC08P041990 GC08P042266
Summaries for VDAC3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for VDAC3 : VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adeninenucleotides through the outer membrane. These channels may also function as a mitochondrialbinding site for hexokinase (see HK1; MIM 142600) and glycerol kinase (GK; MIM 300474) (Rahmani etal., 1998).[supplied by OMIM] UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 Function : Forms a channel through the mitochondrial outer membrane that allows diffusion of smallhydrophilic molecules (By similarity)
Genomic Location for VDAC3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the VDAC3 gene Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.21 VDAC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P042368:
(about GC identifiers )
Start:
42,368,547 bp from pter
End:
42,382,572 bp from pter
Size:
14,026 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000008.9 NT_007995.14 Proteins for VDAC3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
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Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
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R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 (See
protein sequence )Recommended Name: Voltage-dependent anion-selective channel protein 3 Size : 283 amino acids; 30659 Da
Subcellular location : Mitochondrion outer membrane
Secondary accessions : Q9UIS0Alternative splicing : 2 isoforms : Q9Y277-1 Q9Y277-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001129166.1 NP_005653.3 ENSEMBL proteins: ENSP00000022615 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for VDAC3: Assays for VDAC3:
Protein
Domains/ Families for VDAC3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9Y277 ProtoNet protein and cluster: Q9Y277
1 Blocks protein family : IPB001925 Porin UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 Domain : Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (Bysimilarity) Similarity : Belongs to the eukaryotic mitochondrial porin family
Gene Function for VDAC3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001135694 Applied Biosystems Silencer ® siRNAs for VDAC3 Sigma-Aldrich siRNA and siRNA Panels for VDAC3 Sigma-Aldrich shRNA for VDAC3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001135694 UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 Function : Forms a channel through the mitochondrial outer membrane that allows diffusion of smallhydrophilic molecules (By similarity)
Genatlas biochemistry entry for VDAC3 :voltage-dependent anion channel 3,mitochondrial outer membrane,porin 3,allowing diffusion of smallhydrophilic molecules,homolog to murine Vdac3,previously mapped to chromosome 12
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vdac3) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for VDAC3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/11 Interacting proteins for VDAC3 (Q9Y277 1 , 2 ENSP00000022615 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for VDAC3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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PharmGKB )
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Browse Tocris compounds for VDAC3
Transcripts for VDAC3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001135694 Sigma-Aldrich siRNA and siRNA Panels for VDAC3 Sigma-Aldrich shRNA for VDAC3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001135694 NM_005662
REFSEQ mRNAs for VDAC3 gene (2 alternative transcripts): NM_001135694.1 NM_005662.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001135694 NM_005662
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001135694  
Additional cDNA sequence: AF038962.1 AK058201.1 AK095798.1 AK307224.1 AK308760.1 BC056870.1 CR594403.1 CR599765.1 CR608716.1 CR610937.1 CR612232.1 CR618206.1 CR619217.1 CR620684.1 CR620835.1 CR621209.1 CR621225.1 CR624748.1 U90943.1
22 DOTS entries : DT.100878393 DT.455558 DT.40107187 DT.95374075 DT.102830388 DT.101964106 DT.120636408 DT.95220728 DT.120774073 DT.120636402 DT.218840 DT.100878392 DT.100878395 DT.100878402 DT.100878405 DT.120774071 DT.40133665 DT.91794857 DT.95295202 DT.95361574 DT.99996649 DT.100878401
24/485 AceView cDNA sequences (see all 485
):CR608716 BE783137 CR621225 BF724245 AI783659 AI431809 CA411692 BX363660 AL138286 AI682806 CR599765 BX442574 BM013917 BU181724 BF432038 AA613074 BP338046 BQ901222 BM848648 N34378 BM802182 BU620882 AK058201 BM479948
highest scoring ESTs for VDAC3 :AA182849 AA622023 AA653331 H97389 T33622 AF038962 AI090699 AI700834 AI918220 AW190272
Unigene Cluster for VDAC3: Voltage-dependent anion channel 3 Hs.699301 [show with all ESTs ] Unigene Representative Sequence: AK095798 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000022615
Expression for VDAC3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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VDAC3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for VDAC3 1 / 2 / 3
7 probe-sets matching VDAC3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACCTTGTAATSOURCE GeneReport for Unigene cluster: Hs.699301 Expression variation in blood from EXPOLDB for VDAC3
UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 Tissue specificity : Widely expressed. Highest in testis
Orthologs for VDAC3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for VDAC3 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VDAC3 ENSEMBL Gene Tree for VDAC3 Paralogs for VDAC3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for VDAC3 gene VDAC2 2 ENSG00000172974 2 VDAC1 2 Pseudogenes 1 related pseudogene
SNPs/Variants for VDAC3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for VDAC3 (up to first 250kb)
Disorders & Mutations for VDAC3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610029
Medical News for VDAC3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for VDAC3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for VDAC3 gene (see all 22
): Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PubMed id 9653160) 2, 3, 4 Mao M....Chen Z. (1998) Isolation of a novel human voltage-dependent anion channel gene. (PubMed id 9781040) 2, 3, 4 Rahmani Z....Siddiqui A. (1998) The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo. (PubMed id 10833333) 1, 3, 4 Decker W.K. and Craigen W.J. (2000) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 3, 4 Rush J.... Comb M.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis. (PubMed id 10501981) 3, 4 Decker W.K.... Craigen W.J. (1999) The murine voltage-dependent anion channel gene family. Conserved structure and function. (PubMed id 9228078) 1, 3 Sampson M.J....Craigen W.J. (1997) Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? (PubMed id 17683036) 1, 3 Lefievre L....Barratt C.L. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 3 Ewing R.M....Figeys D. (2007) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006)
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Genome Databases showing VDAC3
(According to
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euGenes ,
Ensembl ,
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and/or
H-InvDB )
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Specialized Databases showing VDAC3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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