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VDAC3 Gene

protein-coding   GIFtS: 62

GC08P042368
voltage-dependent anion channel 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
HD-VDAC3 1, 2
VDAC-3 3
hVDAC3 3
Descriptions
Outer mitochondrial membrane protein porin 3 3
voltage-dependent anion channel 3 2
External Ids
HGNC: 126741
Entrez Gene: 74192
UniProtKB: Q9Y2773
Ensembl: ENSG000000786687
Search outside databases for aliases for VDAC3 gene

Previous GC identifers: GC08P041661 GC08P042274 GC08P041990 GC08P042266

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VDAC3:
VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine
nucleotides through the outer membrane. These channels may also function as a mitochondrial
binding site for hexokinase (see HK1; MIM 142600) and glycerol kinase (GK; MIM 300474) (Rahmani et
al., 1998).[supplied by OMIM]

UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small
hydrophilic molecules (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VDAC3 gene  

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

VDAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042368:     (about GC identifiers)

Start:
42,368,547 bp from pter
End:
42,382,572 bp from pter
Size:
14,026 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_007995.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277 (See protein sequence)
Recommended Name: Voltage-dependent anion-selective channel protein 3  
Size: 283 amino acids; 30659 Da
Subcellular location: Mitochondrion outer membrane
Secondary accessions: Q9UIS0
Alternative splicing: 2 isoforms:  Q9Y277-1   Q9Y277-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001129166.1  NP_005653.3  


    ENSEMBL proteins: 
    ENSP00000022615 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for VDAC3  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (VDAC3)
    Human Recombinant Proteins from Abnova (VDAC3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739 mitochondrion IEA--
    GO:0005741 mitochondrial outer membrane TAS9781040
    GO:0005743 mitochondrial inner membrane IEA--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for VDAC3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VDAC3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (VDAC3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (VDAC3)
    Novus Biologicals Antibody for VDAC3

    Assays for VDAC3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR001925 Porin_Euk


       GeneDecks  VDAC3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y277

    ProtoNet protein and cluster: Q9Y277

    1 Blocks protein family: IPB001925 Porin

    UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277
    Domain: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By
    similarity)
    Similarity: Belongs to the eukaryotic mitochondrial porin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VDAC3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (VDAC3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135694

                  Applied Biosystems Silencer® siRNAs for VDAC3

                  Sigma-Aldrich siRNA and siRNA Panels for VDAC3  
                         Sigma-Aldrich shRNA for VDAC3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for VDAC3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135694
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135694
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001135694 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001135694

    UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277
    Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small
    hydrophilic molecules (By similarity)

    Genatlas biochemistry entry for VDAC3:
    voltage-dependent anion channel 3,mitochondrial outer membrane,porin 3,allowing diffusion of small
    hydrophilic molecules,homolog to murine Vdac3,previously mapped to chromosome 12

    8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vdac3):

    behavior/neurologicalcellulargrowth/sizelethality-prenatal/perinatalmuscle
    nervous systemreproductive systemrespiratory system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005515 protein binding IPI17353931
    GO:0008308 voltage-gated anion channel activity TAS9781040
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    2 Invitrogen iPath™ Online BioAtlas - Pathways for VDAC3 (Maps provided by GeneGo):
     Putative erythropoietin signaling pathway (part 2)
     Regulation of apoptosis by mitochondrial proteins

       GeneDecks  VDAC3 for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for VDAC3):
     hsa04020 Calcium signaling pathway
     hsa05012 Parkinson's disease
     hsa05016 Huntington's disease

       GeneDecks  VDAC3 for the pathways selected above  
    About GeneDecksing

    5/11 Interacting proteins for VDAC3 (Q9Y2771, 2 ENSP000000226153) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP4P496621EBI-354196, EBI-1057327
    DDX24Q9GZR72MINT-65428
    HK1ENSP000003486973STRING (score=.909)
    GKENSP000003682263STRING (score=.878)
    SLC25A4ENSP000002814563STRING (score=.833)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662 behavioral fear response IEA--
    GO:0006820 anion transport IEA--
    GO:0007270 nerve-nerve synaptic transmission IEA--
    GO:0007612 learning IEA--
    GO:0015853 adenine transport TAS9781040
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VDAC3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VDAC3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (VDAC3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135694

                  Sigma-Aldrich siRNA and siRNA Panels for VDAC3  
                         Sigma-Aldrich shRNA for VDAC3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001135694  NM_005662  

    REFSEQ mRNAs for VDAC3 gene (2 alternative transcripts): 

    NM_001135694.1   NM_005662.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001135694  NM_005662  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135694
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135694
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001135694 

    Additional cDNA sequence: 

    AF038962.1 AK058201.1 AK095798.1 AK307224.1 AK308760.1 BC056870.1 CR594403.1 CR599765.1 
    CR608716.1 CR610937.1 CR612232.1 CR618206.1 CR619217.1 CR620684.1 CR620835.1 CR621209.1 
    CR621225.1 CR624748.1 U90943.1 

    22 DOTS entries:

    DT.100878393  DT.455558  DT.40107187  DT.95374075  DT.102830388  DT.101964106  DT.120636408  DT.95220728 
    DT.120774073  DT.120636402  DT.218840  DT.100878392  DT.100878395  DT.100878402  DT.100878405  DT.120774071 
    DT.40133665  DT.91794857  DT.95295202  DT.95361574  DT.99996649  DT.100878401 

    24/485 AceView cDNA sequences (see all 485 ):

    CR608716 BE783137 CR621225 BF724245 AI783659 AI431809 CA411692 BX363660 
    AL138286 AI682806 CR599765 BX442574 BM013917 BU181724 BF432038 AA613074 
    BP338046 BQ901222 BM848648 N34378 BM802182 BU620882 AK058201 BM479948 

    highest scoring ESTs for VDAC3:

    AA182849 AA622023 AA653331 H97389 T33622 AF038962 AI090699 AI700834 AI918220 AW190272 

    Unigene Cluster for VDAC3:

    Voltage-dependent anion channel 3
    Hs.699301  [show with all ESTs]
    Unigene Representative Sequence: AK095798


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000022615  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VDAC3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VDAC3

    1 / 2 / 3

    7 probe-sets matching VDAC3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36102_at2, 3 U95-A 2 1.00 0.84 1.00 1.00 AF038962 0.80 0.80 0.80 1

    208846_s_at2, 3 U133-A 2 1.00 0.73 -- -- U90943 0.60 0.75 0.68 1

    208845_at2, 3 U133-A 1 0.91 1.00 -- -- BC002456 0.40 1.00 0.76 1

    208844_at*2, 3 U133-A NULL 0.00 0.00 -- -- BC002456 0.40 1.00 0.76 1

    208846_s_at2 U133Plus2 2 1.00 0.73 -- -- -- -- -- -- --

    208845_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --

    208844_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCTTGTAAT

    SOURCE GeneReport for Unigene cluster: Hs.699301

    Expression variation in blood from EXPOLDB for VDAC3

    UniProtKB/Swiss-Prot: VDAC3_HUMAN, Q9Y277
    Tissue specificity: Widely expressed. Highest in testis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for VDAC3 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VDAC5P1   -- voltage-dependent anion channel 5, pseudogene 94.46(n)
    97.88(a)
    475462  XM_532686.2  XP_532686.2 
    chimpanzee
    (Pan troglodytes)
    VDAC5P1   -- voltage-dependent anion channel 5, pseudogene 99.76(n)
    100(a)
    737891  XM_001138480.1  XP_001138480.1 
    cow
    (Bos taurus)
    VDAC5P1   -- voltage-dependent anion channel 5, pseudogene 93.64(n)
    98.23(a)
    282716  NM_174729.2  NP_777154.1 
    rat
    (Rattus norvegicus)
    Vdac31   -- voltage-dependent anion channel 3 90.69(n)
    95.76(a)
    83532  NM_031355.1  NP_112645.1 
    mouse
    (Mus musculus)
    Vdac31, 5 8 (8.00 cM)5
    voltage-dependent anion channel 31, 5 91.76(n)1
    98.23(a)1
    223351  NM_011696.11  NP_035826.11 
     AK0022965  AK0837855  (see all 22)
    About this table        Species with no ortholog for VDAC3

    ENSEMBL Gene Tree for VDAC3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for VDAC3 gene
    VDAC22  ENSG000001729742  VDAC12  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/71 NCBI SNPs in VDAC3 are shown (see all 71 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs67731,2
    A,C,F,H42382314(+) GGAGAC/TGCTTG 2 -- ut3114Minor allele frequency- N:0.00NS MN EA NA EU WA 914
    rs42623141,2
    H42382941(+) CAATTC/TTGGGA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 416
    --
    rs115582281,2
    H42378581(+) TCGAAG/TGGTGG 2 G/W mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
    --
    rs44679241,2
    H42367957(+) GCACTT/CTGGTA 1 -- ng514Minor allele frequency- C:0.00EU EA WA 414
    rs42810991,2
    H42382968(+) GAAACA/GTGATT 1 -- ng314Minor allele frequency- G:0.00EU EA WA 420
    rs44710251,2
    H42382804(+) GGTTGC/ATTCAC 1 -- ng314Minor allele frequency- A:0.00EU EA WA 420
    rs37366491,2
    A,C,F,H42378456(+) TGTTTA/GTTGCA 1 -- int15Minor allele frequency- G:0.20EA EU WA 1884
    rs78418411,2
    A,C,F,H42373537(+) TTTAAT/CGTAGA 1 -- int18Minor allele frequency- C:0.11EU EA WA 836
    rs70046371,2
    A,C,F,H42369604(+) TAAAAA/GGCCTA 1 -- int14Minor allele frequency- G:0.21EU EA WA 418
    rs168912781,2
    C,F,H42378354(+) AAATAA/GTATTT 1 -- int17Minor allele frequency- G:0.05NA EU EA WA 560
    About this table

    HapMap Linkage Disequilibrium images for VDAC3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610029

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/22 PubMed articles for VDAC3 gene (see all 22 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7419 HGNC: 12674 AceView: VDAC3 Ensembl:ENSG00000078668 euGenes: HUgn7419
    ECgene: VDAC3 H-InvDB: VDAC3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VDAC3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for VDAC3 Antibodies for VDAC3
     Explore super-pooled esiRNAs Proteins for VDAC3
     Lentivirus-delivered shRNAs for VDAC3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for VDAC3

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