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Aliases for VDAC2 Gene

Aliases for VDAC2 Gene

  • Voltage-Dependent Anion Channel 2 2 3
  • Outer Mitochondrial Membrane Protein Porin 2 3 4
  • Voltage-Dependent Anion-Selective Channel Protein 2 3
  • VDAC-2 4
  • HVDAC2 4
  • POR 3

External Ids for VDAC2 Gene

Previous GeneCards Identifiers for VDAC2 Gene

  • GC10P075924
  • GC10P076073
  • GC10P076863
  • GC10P076315
  • GC10P076276
  • GC10P076640
  • GC10P076969
  • GC10P070968

Summaries for VDAC2 Gene

Entrez Gene Summary for VDAC2 Gene

  • This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for VDAC2 Gene

VDAC2 (Voltage-Dependent Anion Channel 2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC3.

UniProtKB/Swiss-Prot for VDAC2 Gene

  • Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective

Gene Wiki entry for VDAC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC2 Gene

Genomics for VDAC2 Gene

Regulatory Elements for VDAC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VDAC2 Gene

Start:
75,210,154 bp from pter
End:
75,231,448 bp from pter
Size:
21,295 bases
Orientation:
Plus strand

Genomic View for VDAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VDAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC2 Gene

Proteins for VDAC2 Gene

  • Protein details for VDAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45880-VDAC2_HUMAN
    Recommended name:
    Voltage-dependent anion-selective channel protein 2
    Protein Accession:
    P45880
    Secondary Accessions:
    • Q5VWK1
    • Q5VWK3
    • Q6IB40
    • Q7L3J5
    • Q9BWK8
    • Q9Y5I6

    Protein attributes for VDAC2 Gene

    Size:
    294 amino acids
    Molecular mass:
    31567 Da
    Quaternary structure:
    • Interacts with hexokinases.
    SequenceCaution:
    • Sequence=CAH73106.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for VDAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VDAC2 Gene

Proteomics data for VDAC2 Gene at MOPED

Post-translational modifications for VDAC2 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys46 and Lys135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VDAC2 (VDAC2)

No data available for DME Specific Peptides for VDAC2 Gene

Domains for VDAC2 Gene

Gene Families for VDAC2 Gene

HGNC:
  • VDAC :Voltage-dependent anion channels

Protein Domains for VDAC2 Gene

Graphical View of Domain Structure for InterPro Entry

P45880

UniProtKB/Swiss-Prot:

VDAC2_HUMAN :
  • P45880
Domain:
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
Family:
  • Belongs to the eukaryotic mitochondrial porin family.
genes like me logo Genes that share domains with VDAC2: view

Function for VDAC2 Gene

Molecular function for VDAC2 Gene

GENATLAS Biochemistry:
voltage-dependent anion channel 2,mitochondrial outer membrane,porin 2,allowing diffusion of small hydrophilic molecules
UniProtKB/Swiss-Prot Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective

Gene Ontology (GO) - Molecular Function for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 15082785
GO:0008308 voltage-gated anion channel activity TAS 8420959
GO:0015288 porin activity IEA --
genes like me logo Genes that share ontologies with VDAC2: view
genes like me logo Genes that share phenotypes with VDAC2: view

Animal Model Products

miRNA for VDAC2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VDAC2 Gene

Localization for VDAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC2 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VDAC2 Gene COMPARTMENTS Subcellular localization image for VDAC2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with VDAC2: view

Pathways for VDAC2 Gene

genes like me logo Genes that share pathways with VDAC2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006820 anion transport IEA --
GO:0032272 negative regulation of protein polymerization IEA --
GO:0044070 regulation of anion transport --
GO:0055085 transmembrane transport IEA --
GO:1903959 regulation of anion transmembrane transport TAS 8420959
genes like me logo Genes that share ontologies with VDAC2: view

Compounds for VDAC2 Gene

(1) ApexBio Compounds for VDAC2 Gene

Compound Action Cas Number
Erastin [571203-78-6]

(1) Drugbank Compounds for VDAC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dihydroxyaluminium
13682-92-3 target inhibitor

(1) Novoseek inferred chemical compound relationships for VDAC2 Gene

Compound -log(P) Hits PubMed IDs
atp 29.4 1
genes like me logo Genes that share compounds with VDAC2: view

Transcripts for VDAC2 Gene

Unigene Clusters for VDAC2 Gene

Voltage-dependent anion channel 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VDAC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11:

ExUns: 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for VDAC2 Gene

GeneLoc Exon Structure for
VDAC2
ECgene alternative splicing isoforms for
VDAC2

Expression for VDAC2 Gene

mRNA expression in normal human tissues for VDAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for VDAC2 Gene

This gene is overexpressed in Nasal epithelium (19.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VDAC2 Gene

SOURCE GeneReport for Unigene cluster for VDAC2 Gene Hs.355927

mRNA Expression by UniProt/SwissProt for VDAC2 Gene

P45880-VDAC2_HUMAN
Tissue specificity: Expressed in all tissues examined
genes like me logo Genes that share expressions with VDAC2: view

Expression partners for VDAC2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VDAC2 Gene

Orthologs for VDAC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VDAC2 35
  • 95.58 (n)
  • 98.98 (a)
VDAC2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VDAC2 35
  • 95.69 (n)
  • 98.64 (a)
VDAC2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vdac2 35
  • 92.33 (n)
  • 96.86 (a)
Vdac2 16
Vdac2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VDAC2 35
  • 99.89 (n)
  • 100 (a)
VDAC2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vdac2 35
  • 92.57 (n)
  • 96.52 (a)
oppossum
(Monodelphis domestica)
Mammalia VDAC2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VDAC2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves VDAC2 35
  • 84.69 (n)
  • 89.75 (a)
VDAC2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VDAC2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vdac2 35
  • 78.56 (n)
  • 86.93 (a)
zebrafish
(Danio rerio)
Actinopterygii vdac2 35
  • 75.74 (n)
  • 83.04 (a)
VDAC2 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17137 37
  • 33 (a)
porin 37
  • 62 (a)
porin 35
  • 60.24 (n)
  • 62.14 (a)
CG17139 36
  • 18 (a)
ManyToMany
CG17140 36
  • 17 (a)
ManyToMany
porin 36
  • 62 (a)
ManyToMany
Porin2 36
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009833 35
  • 60.12 (n)
  • 62.86 (a)
worm
(Caenorhabditis elegans)
Secernentea R05G6.7 37
  • 41 (a)
R05G6.7 35
  • 51.81 (n)
  • 42.03 (a)
vdac-1 36
  • 40 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL247C 35
  • 40.79 (n)
  • 30.32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03553g 35
  • 44.57 (n)
  • 30.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 35
  • 43.19 (n)
  • 25.18 (a)
POR1 36
  • 24 (a)
ManyToMany
POR2 36
  • 20 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04304 35
  • 44.48 (n)
  • 32.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1635.01 35
  • 44.32 (n)
  • 31.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 36
  • 59 (a)
OneToMany
Species with no ortholog for VDAC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC2 Gene

ENSEMBL:
Gene Tree for VDAC2 (if available)
TreeFam:
Gene Tree for VDAC2 (if available)

Paralogs for VDAC2 Gene

Paralogs for VDAC2 Gene

Selected SIMAP similar genes for VDAC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VDAC2: view

Variants for VDAC2 Gene

Sequence variations from dbSNP and Humsavar for VDAC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7304 -- 75,231,207(+) TATAC(A/G)TTATT utr-variant-3-prime, nc-transcript-variant
rs11543 -- 75,210,855(-) CAGCT(C/G)CAGCA utr-variant-5-prime, intron-variant, nc-transcript-variant
rs15249 -- 75,231,219(+) AAATG(C/T)ATTTA utr-variant-3-prime, nc-transcript-variant
rs1050386 -- 75,210,873(+) ACCGC(A/G)AGCGT utr-variant-5-prime, intron-variant, nc-transcript-variant
rs1259497 -- 75,223,105(+) CCTCC(C/T)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC2 Gene

Variant ID Type Subtype PubMed ID
nsv831913 CNV Loss 17160897

Relevant External Links for VDAC2 Gene

HapMap Linkage Disequilibrium report
VDAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VDAC2 Gene

Disorders for VDAC2 Gene

(1) Novoseek inferred disease relationships for VDAC2 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for VDAC2

Genetic Association Database (GAD)
VDAC2
Human Genome Epidemiology (HuGE) Navigator
VDAC2
genes like me logo Genes that share disorders with VDAC2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for VDAC2 Gene

Publications for VDAC2 Gene

  1. Subcellular localization of human voltage-dependent anion channel isoforms. (PMID: 7539795) Yu W.H. … Forte M.A. (J. Biol. Chem. 1995) 3 4 23
  2. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PMID: 8420959) Blachly-Dyson E. … Forte M.A. (J. Biol. Chem. 1993) 3 4 23
  3. Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome. (PMID: 11197169) Yoo B.C. … Lubec G. (Electrophoresis 2001) 3 23
  4. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. (PMID: 15757910) Chandra D. … Tang D.G. (J. Biol. Chem. 2005) 3 23
  5. Human neuronal cell protein responses to Nipah virus infection. (PMID: 17553172) Chang L.Y. … AbuBakar S. (Virol. J. 2007) 3 23

Products for VDAC2 Gene

Sources for VDAC2 Gene

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