Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VDAC2 Gene

Aliases for VDAC2 Gene

  • Voltage Dependent Anion Channel 2 2 3
  • Outer Mitochondrial Membrane Protein Porin 2 3 4
  • Voltage-Dependent Anion Channel 2 3 5
  • VDAC-2 4
  • HVDAC2 4
  • POR 3

External Ids for VDAC2 Gene

Previous GeneCards Identifiers for VDAC2 Gene

  • GC10P075924
  • GC10P076073
  • GC10P076863
  • GC10P076315
  • GC10P076276
  • GC10P076640
  • GC10P076969
  • GC10P070968

Summaries for VDAC2 Gene

Entrez Gene Summary for VDAC2 Gene

  • This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for VDAC2 Gene

VDAC2 (Voltage Dependent Anion Channel 2) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC3.

UniProtKB/Swiss-Prot for VDAC2 Gene

  • Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.

Gene Wiki entry for VDAC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC2 Gene

Genomics for VDAC2 Gene

Regulatory Elements for VDAC2 Gene

Promoters for VDAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VDAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VDAC2 Gene

Chromosome:
10
Start:
75,210,154 bp from pter
End:
75,231,448 bp from pter
Size:
21,295 bases
Orientation:
Plus strand

Genomic View for VDAC2 Gene

Genes around VDAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VDAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VDAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC2 Gene

Proteins for VDAC2 Gene

  • Protein details for VDAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45880-VDAC2_HUMAN
    Recommended name:
    Voltage-dependent anion-selective channel protein 2
    Protein Accession:
    P45880
    Secondary Accessions:
    • Q5VWK1
    • Q5VWK3
    • Q6IB40
    • Q7L3J5
    • Q9BWK8
    • Q9Y5I6

    Protein attributes for VDAC2 Gene

    Size:
    294 amino acids
    Molecular mass:
    31567 Da
    Quaternary structure:
    • Interacts with hexokinases.
    SequenceCaution:
    • Sequence=CAH73106.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for VDAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VDAC2 Gene

Proteomics data for VDAC2 Gene at MOPED

Post-translational modifications for VDAC2 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 79, Lys 136, and Lys 292
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VDAC2 (VDAC2)

No data available for DME Specific Peptides for VDAC2 Gene

Domains & Families for VDAC2 Gene

Gene Families for VDAC2 Gene

Protein Domains for VDAC2 Gene

Graphical View of Domain Structure for InterPro Entry

P45880

UniProtKB/Swiss-Prot:

VDAC2_HUMAN :
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Belongs to the eukaryotic mitochondrial porin family.
Domain:
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
Family:
  • Belongs to the eukaryotic mitochondrial porin family.
genes like me logo Genes that share domains with VDAC2: view

Function for VDAC2 Gene

Molecular function for VDAC2 Gene

GENATLAS Biochemistry:
voltage-dependent anion channel 2,mitochondrial outer membrane,porin 2,allowing diffusion of small hydrophilic molecules
UniProtKB/Swiss-Prot Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.

Gene Ontology (GO) - Molecular Function for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with VDAC2: view
genes like me logo Genes that share phenotypes with VDAC2: view

Animal Models for VDAC2 Gene

MGI Knock Outs for VDAC2:

Animal Model Products

miRNA for VDAC2 Gene

miRTarBase miRNAs that target VDAC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VDAC2 Gene

Localization for VDAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC2 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VDAC2 Gene COMPARTMENTS Subcellular localization image for VDAC2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0042645 mitochondrial nucleoid IDA 18063578
GO:0045121 membrane raft IDA 25204797
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with VDAC2: view

Pathways & Interactions for VDAC2 Gene

genes like me logo Genes that share pathways with VDAC2: view

Gene Ontology (GO) - Biological Process for VDAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044070 regulation of anion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with VDAC2: view

No data available for SIGNOR curated interactions for VDAC2 Gene

Drugs & Compounds for VDAC2 Gene

(5) Drugs for VDAC2 Gene - From: Novoseek, DGIdb, ApexBio, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroxyaluminium Approved Pharma Target, inhibitor 0
PRLX 93936 Investigational Pharma Target 0
Erastin Pharma 0
OLESOXIME Pharma 0
genes like me logo Genes that share compounds with VDAC2: view

Transcripts for VDAC2 Gene

Unigene Clusters for VDAC2 Gene

Voltage-dependent anion channel 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11:

ExUns: 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for VDAC2 Gene

GeneLoc Exon Structure for
VDAC2
ECgene alternative splicing isoforms for
VDAC2

Expression for VDAC2 Gene

mRNA expression in normal human tissues for VDAC2 Gene

Protein differential expression in normal tissues from HIPED for VDAC2 Gene

This gene is overexpressed in Nasal epithelium (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VDAC2 Gene



SOURCE GeneReport for Unigene cluster for VDAC2 Gene Hs.355927

mRNA Expression by UniProt/SwissProt for VDAC2 Gene

P45880-VDAC2_HUMAN
Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with VDAC2: view

Protein tissue co-expression partners for VDAC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VDAC2 Gene

Orthologs for VDAC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VDAC2 35
  • 99.89 (n)
  • 100 (a)
VDAC2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VDAC2 36
  • 97 (a)
OneToOne
VDAC2 35
  • 95.58 (n)
  • 98.98 (a)
dog
(Canis familiaris)
Mammalia VDAC2 35
  • 95.69 (n)
  • 98.64 (a)
VDAC2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vdac2 35
  • 92.33 (n)
  • 96.86 (a)
Vdac2 36
  • 94 (a)
OneToOne
Vdac2 16
oppossum
(Monodelphis domestica)
Mammalia VDAC2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VDAC2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vdac2 35
  • 92.57 (n)
  • 96.52 (a)
chicken
(Gallus gallus)
Aves VDAC2 36
  • 90 (a)
OneToOne
VDAC2 35
  • 84.69 (n)
  • 89.75 (a)
lizard
(Anolis carolinensis)
Reptilia VDAC2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vdac2 35
  • 78.56 (n)
  • 86.93 (a)
zebrafish
(Danio rerio)
Actinopterygii vdac2 35
  • 75.74 (n)
  • 83.04 (a)
VDAC2 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009833 35
  • 60.12 (n)
  • 62.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17137 37
  • 33 (a)
porin 37
  • 62 (a)
CG17139 36
  • 18 (a)
ManyToMany
CG17140 36
  • 17 (a)
ManyToMany
porin 36
  • 62 (a)
ManyToMany
Porin2 36
  • 33 (a)
ManyToMany
porin 35
  • 60.24 (n)
  • 62.14 (a)
worm
(Caenorhabditis elegans)
Secernentea vdac-1 36
  • 40 (a)
OneToMany
R05G6.7 37
  • 41 (a)
R05G6.7 35
  • 51.81 (n)
  • 42.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL247C 35
  • 40.79 (n)
  • 30.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 35
  • 43.19 (n)
  • 25.18 (a)
POR1 36
  • 24 (a)
ManyToMany
POR2 36
  • 20 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03553g 35
  • 44.57 (n)
  • 30.43 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04304 35
  • 44.48 (n)
  • 32.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1635.01 35
  • 44.32 (n)
  • 31.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 36
  • 59 (a)
OneToMany
Species with no ortholog for VDAC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC2 Gene

ENSEMBL:
Gene Tree for VDAC2 (if available)
TreeFam:
Gene Tree for VDAC2 (if available)

Paralogs for VDAC2 Gene

Paralogs for VDAC2 Gene

(2) SIMAP similar genes for VDAC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VDAC2: view

Variants for VDAC2 Gene

Sequence variations from dbSNP and Humsavar for VDAC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_006380 -
rs15249 -- 75,231,219(+) AAATG(C/T)ATTTA nc-transcript-variant, utr-variant-3-prime
rs1050386 -- 75,210,873(+) ACCGC(A/G)AGCGT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1259497 -- 75,223,105(+) CCTCC(C/G/T)GAGTA intron-variant
rs1259498 -- 75,226,983(+) gtctc(C/T)gtaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC2 Gene

Variant ID Type Subtype PubMed ID
nsv831913 CNV Loss 17160897

Variation tolerance for VDAC2 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VDAC2 Gene

HapMap Linkage Disequilibrium report
VDAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VDAC2 Gene

Disorders for VDAC2 Gene

Relevant External Links for VDAC2

Genetic Association Database (GAD)
VDAC2
Human Genome Epidemiology (HuGE) Navigator
VDAC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VDAC2

No disorders were found for VDAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VDAC2 Gene

Publications for VDAC2 Gene

  1. Subcellular localization of human voltage-dependent anion channel isoforms. (PMID: 7539795) Yu W.H. … Forte M.A. (J. Biol. Chem. 1995) 3 4 23 67
  2. VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation. (PMID: 18278581) Valis K. … Kovar J. (Mol. Cell. Biochem. 2008) 3 23
  3. Human neuronal cell protein responses to Nipah virus infection. (PMID: 17553172) Chang L.Y. … AbuBakar S. (Virol. J. 2007) 3 23
  4. High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II. (PMID: 17828567) Engelhardt H. … Zeth K. (J. Membr. Biol. 2007) 3 23
  5. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. (PMID: 15757910) Chandra D. … Tang D.G. (J. Biol. Chem. 2005) 3 23

Products for VDAC2 Gene

Sources for VDAC2 Gene

Back to Top

Content