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Aliases & Descriptions for VDAC2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ23841 2 | | OTTHUMP00000019876 2 | | VDAC-2 3 | | hVDAC2 3 |
| | | Descriptions |
|---|
| Outer mitochondrial membrane protein porin 2 3 | | voltage-dependent anion channel 2 2 |
|
| | Search outside databases for aliases for VDAC2 genePrevious GC identifers: GC10P075924 GC10P076073 GC10P076863 GC10P076315 GC10P076276 |
Summaries for VDAC2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VDAC2_HUMAN, P45880Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective |
Genomic Location for VDAC2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VDAC2 gene 
Entrez Gene cytogenetic band: 10q22 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22VDAC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P076640:
(about GC identifiers)
Start:
|
76,640,569 bp from pter |
End:
|
76,661,212 bp from pter |
Size:
|
20,644 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_008583.16
| Proteins for VDAC2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VDAC2_HUMAN, P45880 (See
protein sequence)Recommended Name: Voltage-dependent anion-selective channel protein 2 Size: 294 amino acids; 31567 Da
Subunit: Interacts with hexokinases (By similarity)
Subcellular location: Mitochondrion outer membrane
Sequence caution: Sequence=CAH73106.1; Type=Erroneous gene model prediction; Sequence=CAI40910.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VWK1 Q5VWK3 Q6IB40 Q7L3J5 Q9BWK8 Q9Y5I6Alternative splicing: 3 isoforms: P45880-3 P45880-1 P45880-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003366.2
ENSEMBL proteins: ENSP00000361686 ENSP00000361635 ENSP00000344876 ENSP00000298468
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VDAC2: Assays for VDAC2: | Protein
Domains/ Families for VDAC2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P45880
ProtoNet protein and cluster: P45880 1 Blocks protein family: IPB001925 Porin
UniProtKB/Swiss-Prot: VDAC2_HUMAN, P45880Domain: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity)Similarity: Belongs to the eukaryotic mitochondrial porin family | Gene Function for VDAC2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003375
Applied Biosystems Silencer® siRNAs for VDAC2
Sigma-Aldrich siRNA and siRNA Panels for VDAC2  Sigma-Aldrich shRNA for VDAC2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003375                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003375                                  untagged cDNA clone in CMV expression vector: NM_003375 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003375
UniProtKB/Swiss-Prot: VDAC2_HUMAN, P45880Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selectiveGenatlas biochemistry entry for VDAC2:voltage-dependent anion channel 2,mitochondrial outer membrane,porin 2,allowing diffusion of small hydrophilic molecules3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for VDAC2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VDAC2 
5/12 Interacting proteins for VDAC2 (P458801 ENSP000003448763) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for VDAC2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VDAC2 1 Novoseek chemical compound relationship for VDAC2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
33.03 |
1 |
17085086 (1) |
About this table
|
Transcripts for VDAC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003375
Sigma-Aldrich siRNA and siRNA Panels for VDAC2  Sigma-Aldrich shRNA for VDAC2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003375 REFSEQ mRNAs for VDAC2 gene: NM_003375.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003375               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003375                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003375                                  untagged cDNA clone in CMV expression vector: NM_003375  Additional cDNA sequence: AK296635.1 AK315919.1 BC000165.2 BC012883.1 BC072407.1 CR456964.1 CR599041.1 CR600576.1 CR600753.1 CR601332.1 CR602116.1 CR604235.1 CR608755.1 CR609406.1 CR611161.1 CR612173.1 CR613503.1 CR617245.1 CR617818.1 CR621927.1 CR626160.1 CR626355.1 CR626773.1 L06328.1 L08666.1 24/35 DOTS entries (see all 35
): DT.99984251 DT.449553 DT.100681911 DT.95082788 DT.100681925 DT.121011673 DT.100681923 DT.92046421 DT.86669435 DT.100681916 DT.91773517 DT.100681910 DT.100681914 DT.121254514 DT.91773516 DT.97785668 DT.97855717 DT.121011876 DT.121254484 DT.100681918 DT.121254530 DT.86840503 DT.100681905 DT.100858359 24/898 AceView cDNA sequences (see all 898
):BU075671 BM703833 N54576 BE766498 F29145 BQ009666 BQ057486 BU784485 BF437721 BM848958 BM272739 BM673615 AA187489 BU628847 CD108952 BG168773 BX398360 BE883074 CR600753 BM851292 BQ226034 BU164824 BM923976 BU684678
highest scoring ESTs for VDAC2:L06328 L08666 AA040931 AA088491 AA099723 AA135432 AA148163 AA177131 AA187489 AA227489 Unigene Cluster for VDAC2: Voltage-dependent anion channel 2 Hs.355927 [show with all ESTs]Unigene Representative Sequence: AK315919
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for VDAC2 (see all 11
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 14a | · | 14b | · | 14c | |
| SP1: | |   | |   | |   | |
| SP2: | |   | |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | |   | |   | |
| SP5: | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VDAC2
4 Ensembl transcripts including schematic representations: ENST00000332211
ENST00000313132
ENST00000344036
ENST00000298468
|
Expression for VDAC2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VDAC2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VDAC2
1 / 2 / 3 4 probe-sets matching VDAC2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACAAATTATG
SOURCE GeneReport for Unigene cluster: Hs.355927
Expression variation in blood from EXPOLDB for VDAC2 UniProtKB/Swiss-Prot: VDAC2_HUMAN, P45880Tissue specificity: Expressed in all tissues examined |
Orthologs for VDAC2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VDAC2 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for VDAC2
ENSEMBL Gene Tree for VDAC2 | Paralogs for VDAC2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VDAC2 gene
- ENSG000001729742 VDAC12 VDAC32
Pseudogenes
- 5 related pseudogenes
|
SNPs/Variants for VDAC2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VDAC2 (up to first 250kb)
|
Disorders & Mutations for VDAC2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 193245
1 Novoseek disease relationship for VDAC2 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0.00 |
1 |
10998068 (1) |
About this table
|
Medical News for VDAC2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VDAC2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/38 PubMed articles for VDAC2 gene (see all 38
):- Subcellular localization of human voltage-dependent anion channel isoforms. (PubMed id 7539795)1, 3, 4 Yu W.H.... Forte M.A. (1995)
- Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PubMed id 8420959)1, 3, 4 Blachly-Dyson E.... Forte M.A. (1993)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis. (PubMed id 10501981)3, 4 Decker W.K.... Craigen W.J. (1999)
- Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered. (PubMed id 10049775)2, 3 Messina A....De Pinto V. (1999)
- Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. (PubMed id 7517385)2, 3 Blachly-Dyson E.... Forte M. (1994)
- A mitochondrial porin cDNA predicts the existence of multiple human porins. (PubMed id 7685033)3, 4 Ha H.... Burrows P.D. (1993)
- VDAC2 inhibits BAK activation and mitochondrial apoptosis. (PubMed id 12881569)1, 3 Cheng E.H....Korsmeyer S.J. (2003)
|
Search for VDAC2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VDAC2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VDAC2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VDAC2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VDAC2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VDAC2:

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Incremental update: 13 Oct 2009
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