Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VDAC1 Gene

Aliases for VDAC1 Gene

  • Voltage-Dependent Anion Channel 1 2 3
  • Outer Mitochondrial Membrane Protein Porin 1 3 4
  • Plasmalemmal Porin 3 4
  • Porin 31HL 3 4
  • Porin 31HM 3 4
  • VDAC-1 3 4
  • Voltage-Dependent Anion-Selective Channel Protein 1 3
  • HVDAC1 4
  • PORIN 3
  • VDAC 4

External Ids for VDAC1 Gene

Summaries for VDAC1 Gene

Entrez Gene Summary for VDAC1 Gene

  • This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

GeneCards Summary for VDAC1 Gene

VDAC1 (Voltage-Dependent Anion Channel 1) is a Protein Coding gene. Diseases associated with VDAC1 include gonorrhea and cystic fibrosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include porin activity and voltage-gated anion channel activity. An important paralog of this gene is VDAC3.

UniProtKB/Swiss-Prot for VDAC1 Gene

  • Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Wiki entry for VDAC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC1 Gene

Genomics for VDAC1 Gene

Genomic Location for VDAC1 Gene

Start:
133,971,875 bp from pter
End:
134,005,389 bp from pter
Size:
33,515 bases
Orientation:
Minus strand

Genomic View for VDAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VDAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC1 Gene

Regulatory Elements for VDAC1 Gene

Proteins for VDAC1 Gene

  • Protein details for VDAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21796-VDAC1_HUMAN
    Recommended name:
    Voltage-dependent anion-selective channel protein 1
    Protein Accession:
    P21796
    Secondary Accessions:
    • B3KVK4
    • D3DQ93
    • Q5FVE7
    • Q9UIQ5
    • Q9UPL0

    Protein attributes for VDAC1 Gene

    Size:
    283 amino acids
    Molecular mass:
    30773 Da
    Quaternary structure:
    • Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with BOP/C22orf29 (via BH3 domain). Interacts with influenza A virus PB1-F2 protein. Interacts with HK1. The HK1-VDAC1 complex interacts with ATF2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for VDAC1 Gene

neXtProt entry for VDAC1 Gene

Proteomics data for VDAC1 Gene at MOPED

Post-translational modifications for VDAC1 Gene

  • Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury.
  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys109, Lys252, and Lys266

Other Protein References for VDAC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VDAC1 Gene

Domains for VDAC1 Gene

Gene Families for VDAC1 Gene

HGNC:
  • VDAC :Voltage-dependent anion channels

Protein Domains for VDAC1 Gene

UniProtKB/Swiss-Prot:

VDAC1_HUMAN
Domain:
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity:
    • P21796
Family:
  • Belongs to the eukaryotic mitochondrial porin family.:
    • P21796
genes like me logo Genes that share domains with VDAC1: view

Function for VDAC1 Gene

Molecular function for VDAC1 Gene

GENATLAS Biochemistry: voltage-dependent anion selective channel 1,mitochondrial outer membrane,tissue specific (skeletal muscle),allowing diffusion of small hydrophilic molecules
UniProtKB/Swiss-Prot Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Ontology (GO) - Molecular Function for VDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21370995
GO:0008308 voltage-gated anion channel activity TAS 8420959
GO:0015288 porin activity IEA --
GO:0019901 protein kinase binding IPI 21370995
genes like me logo Genes that share ontologies with VDAC1: view
genes like me logo Genes that share phenotypes with VDAC1: view

Animal Models for VDAC1 Gene

MGI Knock Outs for VDAC1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VDAC1 Gene

Localization for VDAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC1 Gene

Mitochondrion outer membrane. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VDAC1 Gene COMPARTMENTS Subcellular localization image for VDAC1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for VDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005741 mitochondrial outer membrane IDA 17008324
GO:0005743 mitochondrial inner membrane IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with VDAC1: view

Pathways for VDAC1 Gene

genes like me logo Genes that share pathways with VDAC1: view

Pathways by source for VDAC1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for VDAC1 Gene
2 Qiagen pathways for VDAC1 Gene
2 Cell Signaling Technology pathways for VDAC1 Gene

Gene Ontology (GO) - Biological Process for VDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0006820 anion transport IEA --
GO:0006915 apoptotic process TAS 10365962
GO:0007268 synaptic transmission --
GO:0007270 neuron-neuron synaptic transmission IEA --
genes like me logo Genes that share ontologies with VDAC1: view

Compounds for VDAC1 Gene

(1) Drugbank Compounds for VDAC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dihydroxyaluminium
13682-92-3 target inhibitor

(103) Novoseek inferred chemical compound relationships for VDAC1 Gene

Compound -log(P) Hits PubMed IDs
ptpc 74.2 5
imipenem 57.6 11
cefoxitin 53.7 6
lipid 52.4 58
cefepime 51.7 3
genes like me logo Genes that share compounds with VDAC1: view

Transcripts for VDAC1 Gene

Unigene Clusters for VDAC1 Gene

Voltage-dependent anion channel 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC1 Gene

No ASD Table

Relevant External Links for VDAC1 Gene

GeneLoc Exon Structure for
VDAC1
ECgene alternative splicing isoforms for
VDAC1

Expression for VDAC1 Gene

mRNA expression in normal human tissues for VDAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VDAC1 Gene

This gene is overexpressed in Muscle - Skeletal (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VDAC1 Gene

SOURCE GeneReport for Unigene cluster for VDAC1 Gene Hs.519320

mRNA Expression by UniProt/SwissProt for VDAC1 Gene

P21796-VDAC1_HUMAN
Tissue specificity: Heart, liver and skeletal muscle
genes like me logo Genes that share expressions with VDAC1: view

Orthologs for VDAC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VDAC1 36
  • 100 (n)
  • 100 (a)
VDAC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VDAC1 36
  • 92.93 (n)
  • 99.29 (a)
VDAC1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VDAC1 36
  • 92.34 (n)
  • 99.65 (a)
VDAC1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vdac1 36
  • 89.87 (n)
  • 98.59 (a)
Vdac1 16
Vdac1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VDAC1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VDAC1 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vdac1 36
  • 89.99 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves VDAC1 36
  • 84.69 (n)
  • 95.41 (a)
VDAC1 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VDAC1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vdac1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11004 36
vdac1 36
  • 78.09 (n)
  • 89.75 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28173 36
vdac1 36
  • 77.15 (n)
  • 85.51 (a)
vdac1 37
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17139 37
  • 19 (a)
ManyToMany
CG17140 37
  • 16 (a)
ManyToMany
porin 37
  • 58 (a)
ManyToMany
Porin2 37
  • 34 (a)
ManyToMany
porin 38
  • 58 (a)
CG17137 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea vdac-1 37
  • 40 (a)
OneToMany
R05G6.7 38
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 37
  • 24 (a)
ManyToMany
POR2 37
  • 21 (a)
ManyToMany
POR2 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5787 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 37
  • 56 (a)
OneToMany
Species with no ortholog for VDAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC1 Gene

ENSEMBL:
Gene Tree for VDAC1 (if available)
TreeFam:
Gene Tree for VDAC1 (if available)

Paralogs for VDAC1 Gene

Paralogs for VDAC1 Gene

Selected SIMAP similar genes for VDAC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VDAC1: view

Variants for VDAC1 Gene

Sequence variations from dbSNP and Humsavar for VDAC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7404 -- 133,972,170(-) TTTTT(G/T)GCCCT utr-variant-3-prime, nc-transcript-variant
rs452715 -- 133,977,275(+) CACCT(A/G)TGCAT intron-variant
rs1055473 -- 133,981,276(-) TTCTA(C/T)CTAAT intron-variant
rs1056722 -- 133,972,072(-) AGAAT(C/T)TAAAT utr-variant-3-prime, nc-transcript-variant
rs1644289 -- 133,979,723(+) aggcc(C/G)ggccA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC1 Gene

Variant ID Type Subtype PubMed ID
nsv5009 CNV Insertion 18451855

Relevant External Links for VDAC1 Gene

HapMap Linkage Disequilibrium report
VDAC1

Disorders for VDAC1 Gene

(2) MalaCards Diseases for VDAC1 Gene

Search for VDAC1 Gene in MalaCards »

(22) Novoseek inferred disease relationships for VDAC1 Gene

Disease -log(P) Hits PubMed IDs
gonorrhea 37 1
cystic fibrosis 33.9 11
shock endotoxic 20.7 2
mitochondrial diseases 10.8 1
typhoid fever 5.26 7

Relevant External Links for VDAC1

Genetic Association Database (GAD)
VDAC1
Human Genome Epidemiology (HuGE) Navigator
VDAC1
genes like me logo Genes that share disorders with VDAC1: view

No data available for UniProtKB/Swiss-Prot for VDAC1 Gene

Publications for VDAC1 Gene

  1. Subcellular localization of human voltage-dependent anion channel isoforms. (PMID: 7539795) Yu W.H. … Forte M.A. (J. Biol. Chem. 1995) 3 4 23
  2. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PMID: 8420959) Blachly-Dyson E. … Forte M.A. (J. Biol. Chem. 1993) 3 4 23
  3. Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical. (PMID: 1657034) Juergens L. … Hilschmann N. (Biol. Chem. Hoppe-Seyler 1991) 3 4 23
  4. Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. (PMID: 7517385) Blachly-Dyson E. … Forte M. (Genomics 1994) 2 3 23
  5. Study of PTPC composition during apoptosis for identification of viral protein target. (PMID: 15033708) Verrier F. … Brenner C. (Ann. N. Y. Acad. Sci. 2003) 3 4 23

Products for VDAC1 Gene

Sources for VDAC1 Gene

Back to Top

Content