Aliases for VDAC1 Gene
External Ids for VDAC1 Gene
Previous GeneCards Identifiers for VDAC1 Gene
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
GeneCards Summary for VDAC1 Gene
VDAC1 (Voltage Dependent Anion Channel 1) is a Protein Coding gene. Diseases associated with VDAC1 include Cystic Fibrosis and Gerstmann-Straussler Disease. Among its related pathways are Apoptosis and Autophagy and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein kinase binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC2.
UniProtKB/Swiss-Prot for VDAC1 Gene
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).