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Aliases & Descriptions for VDAC1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC111064 1, 2 | | OTTHUMP00000165946 2 | | OTTHUMP00000165947 2 | | PORIN 1, 2 | | PORIN-31-HL 2 | | VDAC 3 | | VDAC-1 3 | | hVDAC1 3 |
| | | Descriptions |
|---|
| Outer mitochondrial membrane protein porin 1 3 | | Plasmalemmal porin 3 | | Porin 31HL 3 | | Porin 31HM 3 | | voltage-dependent anion channel 1 2 |
|
| | Search outside databases for aliases for VDAC1 genePrevious GC identifers: GC05M132956 GC05M133821 GC05M133338 GC05M133383 |
Summaries for VDAC1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosisGene Wiki entry for VDAC1 |
Genomic Location for VDAC1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VDAC1 gene 
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31VDAC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M133336:
(about GC identifiers)
Start:
|
133,335,505 bp from pter |
End:
|
133,368,723 bp from pter |
Size:
|
33,219 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_034772.5
| Proteins for VDAC1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796 (See
protein sequence)Recommended Name: Voltage-dependent anion-selective channel protein 1 Size: 283 amino acids; 30773 Da
Subunit: Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein
Subcellular location: Mitochondrion outer membrane. Cell membrane
PDB structure from and Proteopedia :2JK4 (3D)
 2K4T (3D)
 
Secondary accessions: Q5FVE7 Q9UIQ5 Q9UPL0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003365.1
ENSEMBL proteins: ENSP00000265333 ENSP00000378484 ENSP00000378487
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for VDAC1: Assays for VDAC1: | Protein
Domains/ Families for VDAC1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P21796
ProtoNet protein and cluster: P21796 1 Blocks protein family: IPB001925 Porin
UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Domain: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activitySimilarity: Belongs to the eukaryotic mitochondrial porin family | Gene Function for VDAC1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003374
Applied Biosystems Silencer® siRNAs for VDAC1
Sigma-Aldrich siRNA and siRNA Panels for VDAC1  Sigma-Aldrich shRNA Panels and shRNA for VDAC1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003374                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003374                                  untagged cDNA clone in CMV expression vector: NM_003374 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003374
UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosisGenatlas biochemistry entry for VDAC1:voltage-dependent anion selective channel 1,mitochondrial outer membrane,tissue specific (skeletal muscle),allowing diffusion of small hydrophilic molecules4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vdac1):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for VDAC1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VDAC1 
5/77 Interacting proteins for VDAC1 (P217961, 2 ENSP000002653333) via UniProtKB, MINT, and/or STRING (see all 77
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VDAC1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VDAC1 10/57 Novoseek chemical compound relationships for VDAC1 gene (see all 57
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ptpc |
72.00 |
4 |
10620603 (1), 11175251 (1), 15377997 (1), 15033708 (1) |
| lipid |
52.78 |
63 |
17336328 (4), 7681063 (2), 8703976 (2), 10479618 (2) (see all 50) |
| atp |
51.90 |
43 |
7529026 (5), 16354668 (2), 9387093 (1), 17085086 (1) (see all 28) |
| adp |
45.21 |
14 |
1335019 (2), 9387093 (1), 16354668 (1), 18607100 (1) (see all 12) |
| beta-lactam |
43.73 |
6 |
11454211 (1), 8314292 (1), 15155215 (1), 15067581 (1) |
| nadh |
42.98 |
23 |
7507479 (3), 15752713 (3), 15630200 (3), 19159355 (2) (see all 13) |
| benzodiazepine |
41.86 |
10 |
1373732 (1), 9503034 (1), 16026165 (1), 7689983 (1) (see all 7) |
| phospholipid |
38.89 |
14 |
8798589 (2), 19033201 (1), 9178614 (1), 1335527 (1) (see all 13) |
| dccd |
36.81 |
4 |
9932652 (1), 9654059 (1), 8647283 (1) |
| bacteriorhodopsin |
36.18 |
3 |
7640299 (1), 1464373 (1), 7857960 (1) |
About this table
|
Transcripts for VDAC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003374
Sigma-Aldrich siRNA and siRNA Panels for VDAC1  Sigma-Aldrich shRNA Panels and shRNA for VDAC1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003374 REFSEQ mRNAs for VDAC1 gene: NM_003374.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003374               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003374                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003374                                  untagged cDNA clone in CMV expression vector: NM_003374  Additional cDNA sequence: AK095989.1 AK122953.1 AK293639.1 BC008482.1 BC071168.1 BC090042.1 CR595129.1 CR595756.1 CR596905.1 CR598077.1 CR603026.1 CR605140.1 CR606302.1 CR607580.1 CR607667.1 CR611832.1 CR612086.1 CR612480.1 CR612783.1 CR616336.1 CR617397.1 CR619959.1 CR621984.1 CR623138.1 CR624238.1 L06132.1 24/34 DOTS entries (see all 34
): DT.97861572 DT.95273539 DT.451941 DT.95273565 DT.120871794 DT.100880956 DT.100880950 DT.121297354 DT.95273540 DT.40129022 DT.120871767 DT.92460271 DT.100032191 DT.100829458 DT.121318065 DT.86841159 DT.120871692 DT.120871745 DT.100880947 DT.100880949 DT.100880957 DT.120871717 DT.120909548 DT.92416501 24/825 AceView cDNA sequences (see all 825
):AW238841 AU280187 AI684259 BI255508 BQ004673 AU104462 BG679865 BU163049 AA313735 AU118465 BG681532 CR623923 CR616336 BU173647 BU196916 AU143066 BQ950018 BE891133 BE877826 AA053367 BE272810 F30089 CA446102 BI335741
highest scoring ESTs for VDAC1:L06132 AK095989 AK122953 AL543727 AL548202 AL559756 AU099180 AU119918 AU128935 AU143407 Unigene Cluster for VDAC1: Voltage-dependent anion channel 1 Hs.519320 [show with all ESTs]Unigene Representative Sequence: AK122953
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000265333
ENST00000395044
ENST00000395047
|
Expression for VDAC1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VDAC1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VDAC1
1 / 2 / 3 6 probe-sets matching VDAC1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGACAACAC
SOURCE GeneReport for Unigene cluster: Hs.519320
Expression variation in blood from EXPOLDB for VDAC1 UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Tissue specificity: Heart, liver and skeletal muscle |
Orthologs for VDAC1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VDAC1 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for VDAC1
ENSEMBL Gene Tree for VDAC1 | Paralogs for VDAC1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VDAC1 gene
- VDAC22 ENSG000001729742 VDAC32
Pseudogenes
- 9 related pseudogenes
|
SNPs/Variants for VDAC1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VDAC1 (up to first 250kb)
|
Disorders & Mutations for VDAC1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604492
10/20 Novoseek disease relationships for VDAC1 gene (see all 20
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gonorrhea |
39.31 |
1 |
10438365 (1) |
| cystic fibrosis |
34.85 |
13 |
12235488 (2), 1707632 (2), 9433706 (1), 7993658 (1) (see all 9) |
| shock endotoxic |
22.71 |
2 |
1321849 (1), 1335527 (1) |
| typhoid fever |
8.08 |
9 |
8222322 (4), 8384733 (2), 8427032 (1) |
| salmonella infections |
6.40 |
1 |
8409588 (1) |
| sepsis |
3.83 |
1 |
16045546 (1) |
| carcinoma |
1.05 |
1 |
17017437 (1) |
| inflammation |
0.98 |
2 |
1321849 (1), 1335527 (1) |
| necrosis |
0.00 |
4 |
9125547 (2), 1335527 (1), 8132346 (1) |
| shock |
0.00 |
8 |
11583900 (1), 17085086 (1), 18004711 (1), 16094700 (1) (see all 5) |
About this table
|
Medical News for VDAC1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VDAC1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/355 PubMed articles for VDAC1 gene (see all 355
):- Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PubMed id 8420959)1, 3, 4 Blachly-Dyson E.... Forte M.A. (1993)
- Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical. (PubMed id 1657034)1, 3, 4 Juergens L.... Hilschmann N. (1991)
- Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. (PubMed id 7517385)1, 2, 3 Blachly-Dyson E.... Forte M. (1994)
- Subcellular localization of human voltage-dependent anion channel isoforms. (PubMed id 7539795)1, 3, 4 Yu W.H.... Forte M.A. (1995)
- Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. (PubMed id 18755977)1, 3, 4 Hiller S....Wagner G. (2008)
- Study of PTPC composition during apoptosis for identification of viral protein target. (PubMed id 15033708)1, 3, 4 Verrier F.... Brenner C. (2003)
- Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy? (PubMed id 11845315)1, 3, 4 Thinnes F.P.... Hilschmann N. (2001)
- Structure of the human voltage-dependent anion channel. (PubMed id 18832158)3, 4 Bayrhuber M.... Zeth K. (2008)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)3, 4 Nousiainen M.... Koerner R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
|
Search for VDAC1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VDAC1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VDAC1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VDAC1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VDAC1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for VDAC1:

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