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VDAC1 Gene

protein-coding GIFtS: 63

GC05M133336

voltage-dependent anion channel 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC111064 ^¹, ²
OTTHUMP00000165946 ^²
OTTHUMP00000165947 ^²
PORIN ^¹, ²
PORIN-31-HL ^²
VDAC ^³
VDAC-1 ^³
hVDAC1 ^³

Descriptions
Outer mitochondrial membrane protein porin 1 ^³
Plasmalemmal porin ^³
Porin 31HL ^³
Porin 31HM ^³
voltage-dependent anion channel 1 ^²

External Ids
HGNC: 12669¹
Entrez Gene: 7416²
UniProtKB: P21796³
Ensembl: ENSG00000213585⁷

Search outside databases for aliases for VDAC1 gene

Previous GC identifers: GC05M132956 GC05M133821 GC05M133338 GC05M133383

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796

Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane.

The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules;

in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open

conformation at low or zero membrane potential and a closed conformation at potentials above 30-40

mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May

participate in the formation of the permeability transition pore complex (PTPC) responsible for

the release of mitochondrial products that triggers apoptosis

Gene Wiki entry for VDAC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VDAC1 gene

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31

VDAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M133336: (about GC identifiers)

Start:	133,335,505 bp from pter
End:	133,368,723 bp from pter
Size:	33,219 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796 (See protein sequence)

Recommended Name: Voltage-dependent anion-selective channel protein 1

Size: 283 amino acids; 30773 Da

Subunit: Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with

influenza A virus PB1-F2 protein

Subcellular location: Mitochondrion outer membrane. Cell membrane

PDB structure from and Proteopedia :

2JK4 (3D)

2K4T (3D)

Secondary accessions: Q5FVE7 Q9UIQ5 Q9UPL0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003365.1

ENSEMBL proteins:

ENSP00000265333 ENSP00000378484 ENSP00000378487

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VDAC/Porin, VDAC1/Porin - HRP , VDAC1 / Porin)
	Human Recombinant Proteins from Abnova (VDAC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	8420959
GO:0005741	mitochondrial outer membrane	TAS	8420959
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0042645	mitochondrial nucleoid	IDA	18063578

About this table

Antibodies for VDAC1:

	Invitrogen Antibodies for VDAC1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for VDAC1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for VDAC1 (VDAC)
	Antibodies from Abcam (VDAC/Porin, VDAC1/Porin - HRP , VDAC1 / Porin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VDAC1)
	Novus Biologicals Antibodies for VDAC1

Assays for VDAC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21796

ProtoNet protein and cluster: P21796

1 Blocks protein family: IPB001925 Porin

UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796

Domain: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical

N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity

Similarity: Belongs to the eukaryotic mitochondrial porin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VDAC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VDAC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003374

Applied Biosystems Silencer® siRNAs for VDAC1

Sigma-Aldrich siRNA and siRNA Panels for VDAC1

Sigma-Aldrich shRNA Panels and shRNA for VDAC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VDAC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003374
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003374
untagged cDNA clone in CMV expression vector: NM_003374

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003374

UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796

Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane.

The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules;

in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open

conformation at low or zero membrane potential and a closed conformation at potentials above 30-40

mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May

participate in the formation of the permeability transition pore complex (PTPC) responsible for

the release of mitochondrial products that triggers apoptosis

Genatlas biochemistry entry for VDAC1:

voltage-dependent anion selective channel 1,mitochondrial outer membrane,tissue specific (skeletal

muscle),allowing diffusion of small hydrophilic molecules

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vdac1):

behavior/neurological

growth/size

lethality-prenatal/perinatal

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0008308	voltage-gated anion channel activity	TAS	8420959

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for VDAC1

5/77 Interacting proteins for VDAC1 (P21796^{1, 2} ENSP00000265333³) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC25A6	P12236², ENSP00000370808³	MINT-4054731 STRING (score=.901)
GSN	P06396², ENSP00000362924³	MINT-4792996 STRING (score=.884)
SLC25A5	P05141², ENSP00000360671³	MINT-4054731 STRING (score=.836)
DCD	P81605¹	EBI-354158, EBI-395625
GABARAPL2	P60520¹	EBI-354158, EBI-720116

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001662	behavioral fear response	IEA	--
GO:0006820	anion transport	TAS	8420959
GO:0007270	nerve-nerve synaptic transmission	IEA	--
GO:0007612	learning	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VDAC1
10/57 Novoseek chemical compound relationships for VDAC1 gene (see all 57 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ptpc	72.00	4	10620603 (1), 11175251 (1), 15377997 (1), 15033708 (1)
lipid	52.78	63	17336328 (4), 7681063 (2), 8703976 (2), 10479618 (2) (see all 50)
atp	51.90	43	7529026 (5), 16354668 (2), 9387093 (1), 17085086 (1) (see all 28)
adp	45.21	14	1335019 (2), 9387093 (1), 16354668 (1), 18607100 (1) (see all 12)
beta-lactam	43.73	6	11454211 (1), 8314292 (1), 15155215 (1), 15067581 (1)
nadh	42.98	23	7507479 (3), 15752713 (3), 15630200 (3), 19159355 (2) (see all 13)
benzodiazepine	41.86	10	1373732 (1), 9503034 (1), 16026165 (1), 7689983 (1) (see all 7)
phospholipid	38.89	14	8798589 (2), 19033201 (1), 9178614 (1), 1335527 (1) (see all 13)
dccd	36.81	4	9932652 (1), 9654059 (1), 8647283 (1)
bacteriorhodopsin	36.18	3	7640299 (1), 1464373 (1), 7857960 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VDAC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VDAC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003374

Sigma-Aldrich siRNA and siRNA Panels for VDAC1

Sigma-Aldrich shRNA Panels and shRNA for VDAC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003374

REFSEQ mRNAs for VDAC1 gene:

NM_003374.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003374

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003374
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003374
                                 untagged cDNA clone in CMV expression vector: NM_003374

Additional cDNA sequence:

AK095989.1 AK122953.1 AK293639.1 BC008482.1 BC071168.1 BC090042.1 CR595129.1 CR595756.1

CR596905.1 CR598077.1 CR603026.1 CR605140.1 CR606302.1 CR607580.1 CR607667.1 CR611832.1

CR612086.1 CR612480.1 CR612783.1 CR616336.1 CR617397.1 CR619959.1 CR621984.1 CR623138.1

CR624238.1 L06132.1

24/34 DOTS entries (see all 34 ):

DT.97861572 DT.95273539 DT.451941 DT.95273565 DT.120871794 DT.100880956 DT.100880950 DT.121297354

DT.95273540 DT.40129022 DT.120871767 DT.92460271 DT.100032191 DT.100829458 DT.121318065 DT.86841159

DT.120871692 DT.120871745 DT.100880947 DT.100880949 DT.100880957 DT.120871717 DT.120909548 DT.92416501

24/825 AceView cDNA sequences (see all 825 ):

AW238841 AU280187 AI684259 BI255508 BQ004673 AU104462 BG679865 BU163049

AA313735 AU118465 BG681532 CR623923 CR616336 BU173647 BU196916 AU143066

BQ950018 BE891133 BE877826 AA053367 BE272810 F30089 CA446102 BI335741

highest scoring ESTs for VDAC1:

L06132 AK095989 AK122953 AL543727 AL548202 AL559756 AU099180 AU119918 AU128935 AU143407

Unigene Cluster for VDAC1:

Voltage-dependent anion channel 1

Hs.519320 [show with all ESTs]

Unigene Representative Sequence: AK122953

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000265333 ENST00000395044 ENST00000395047

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VDAC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VDAC1

¹ / ² / ³

6 probe-sets matching VDAC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40198_at²^{, 3}	U95-A	2	1.00	0.97	0.99	1.03	L06132	1.00	1.00	1.00	1
31608_g_at²^{, 3}	U95-A	14	1.00	0.14	0.99	0.97	AJ002428	0.20	1.00	0.72	1
212038_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AL515918	0.60	0.75	0.68	1
217140_s_at²^{, 3}	U133-A	11	1.00	0.15	--	--	AJ002428	0.20	1.00	0.72	1
212038_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
217140_s_at²	U133Plus2	11	1.00	0.15	--	--	--	--	--	--	--

GeneDecks VDAC1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGACAACAC

SOURCE GeneReport for Unigene cluster: Hs.519320
Expression variation in blood from EXPOLDB for VDAC1
UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796
Tissue specificity: Heart, liver and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VDAC1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VDAC1¹	--	voltage-dependent anion channel 1	92.34(n) 99.65(a)	474681 XM_531907.2 XP_531907.1
chimpanzee (Pan troglodytes)	VDAC1¹	--	voltage-dependent anion channel 1	99.53(n) 98.94(a)	745717 XM_001151901.1 XP_001151901.1
cow (Bos taurus)	VDAC1¹	--	voltage-dependent anion channel 1	92.93(n) 99.29(a)	282119 NM_174485.3 NP_776910.2
rat (Rattus norvegicus)	Vdac1¹	--	voltage-dependent anion channel 1	89.99(n) 98.59(a)	83529 NM_031353.1 NP_112643.1
mouse (Mus musculus)	Vdac1^{1, 5}	11 (29.00 cM)⁵	voltage-dependent anion channel 1^{1, 5}	89.87(n)¹ 98.59(a)¹	22333¹ NM_011694.2¹ NP_035824.1¹ AK002740⁵ AK146239⁵ (see all 30)

About this table Species with no ortholog for VDAC1

ENSEMBL Gene Tree for VDAC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VDAC1 gene

VDAC2² ENSG00000172974² VDAC3²

Pseudogenes

9 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/172 NCBI SNPs in VDAC1 are shown (see all 172 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 48)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7404^1,2	A,C,F,H	133335760(-)	`TTTTTT/GGCCCT`	1	--	ut3¹		8	NA MN EU EA WA	740
	rs2288834^1,2	A,C,F,H	133369417(-)	`ATGTGC/TAGAAT`	1	--	ng3¹		9	EA EU WA	2336
	rs13354887^1,2	F,H	133335236(+)	`ccccaG/Aataaa`	1	--	ng5¹		4	EU EA WA	420
	rs2066944^1,2	A,C,F,H,O	133355058(+)	`GCTAAA/TGCTGA`	1	--	int¹		10	EA EU WA NA	2312
	rs11242200^1,2	A,C,F,H	133353680(+)	`AGGGAA/GTAATT`	1	--	int¹		7	EU EA WA NA	544
	rs6893145^1,2	A,C,F,H	133356724(+)	`AAGACT/CACCAG`	1	--	int¹		9	EU EA WA	1016
	rs4958205^1,2	A,C,F,H	133365510(+)	`AATGCG/ACCCAG`	1	--	int¹		9	EU EA WA	1012
	rs2291633^1,2	C,F,H,O	133337093(-)	`ACTTAT/CTTCTG`	1	--	int¹		13	NA EA EU WA	1218
	rs10078324^1,2	A,C,F,H	133357830(+)	`ACTCAC/TTGAGT`	1	--	int¹		9	EU EA WA	1018
--	rs6878988^1,2	A,C,F,H	133352757(+)	`GAACCC/ATGTGT`	1	--	int¹		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for VDAC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604492

10/20 Novoseek disease relationships for VDAC1 gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gonorrhea	39.31	1	10438365 (1)
cystic fibrosis	34.85	13	12235488 (2), 1707632 (2), 9433706 (1), 7993658 (1) (see all 9)
shock endotoxic	22.71	2	1321849 (1), 1335527 (1)
typhoid fever	8.08	9	8222322 (4), 8384733 (2), 8427032 (1)
salmonella infections	6.40	1	8409588 (1)
sepsis	3.83	1	16045546 (1)
carcinoma	1.05	1	17017437 (1)
inflammation	0.98	2	1321849 (1), 1335527 (1)
necrosis	0.00	4	9125547 (2), 1335527 (1), 8132346 (1)
shock	0.00	8	11583900 (1), 17085086 (1), 18004711 (1), 16094700 (1) (see all 5)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/355 PubMed articles for VDAC1 gene (see all 355 ):

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PubMed id 8420959)^{1, 3, 4} Blachly-Dyson E.... Forte M.A. (1993)
Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical. (PubMed id 1657034)^{1, 3, 4} Juergens L.... Hilschmann N. (1991)
Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. (PubMed id 7517385)^{1, 2, 3} Blachly-Dyson E.... Forte M. (1994)
Subcellular localization of human voltage-dependent anion channel isoforms. (PubMed id 7539795)^{1, 3, 4} Yu W.H.... Forte M.A. (1995)
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. (PubMed id 18755977)^{1, 3, 4} Hiller S....Wagner G. (2008)
Study of PTPC composition during apoptosis for identification of viral protein target. (PubMed id 15033708)^{1, 3, 4} Verrier F.... Brenner C. (2003)
Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy? (PubMed id 11845315)^{1, 3, 4} Thinnes F.P.... Hilschmann N. (2001)
Structure of the human voltage-dependent anion channel. (PubMed id 18832158)^{3, 4} Bayrhuber M.... Zeth K. (2008)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7416	HGNC: 12669	AceView: VDAC1	Ensembl:ENSG00000213585	euGenes: HUgn7416
ECgene: VDAC1	H-InvDB: VDAC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for VDAC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VDAC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VDAC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VDAC1		Antibodies for VDAC1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VDAC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VDAC1)
	Antibodies (VDAC1)
	Chimera RNAi (VDAC1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for VDAC1 (VDAC)

	Recombinant Proteins (VDAC/Porin, VDAC1/Porin - HRP , VDAC1 / Porin)
	Antibodies (VDAC/Porin, VDAC1/Porin - HRP , VDAC1 / Porin)

Search OriGene for VDAC1

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Antibodies for VDAC1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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VDAC1 Gene at Home site.
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VDAC1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VDAC1

Summaries
for VDAC1

Genomic Location
for VDAC1

Proteins
for VDAC1

Protein Domains/
Families
for VDAC1

Gene Function
for VDAC1

Pathways & Interactions
for VDAC1

Drugs & Compounds
for VDAC1

Transcripts
for VDAC1

Expression
for VDAC1

Orthologs
for VDAC1

Paralogs
for VDAC1

SNPs/Variants
for VDAC1

Disorders & Mutations
for VDAC1

Medical News
for VDAC1

Publications
for VDAC1

Search for VDAC1

Genome Databases showing VDAC1

Other Databases showing VDAC1

Specialized Databases showing VDAC1

Licensable Technologies
for VDAC1

Services
for VDAC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VDAC1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VDAC1

Summariesfor VDAC1

Genomic Locationfor VDAC1

Proteinsfor VDAC1

Protein Domains/Familiesfor VDAC1

Gene Functionfor VDAC1

Pathways & Interactionsfor VDAC1

Drugs & Compoundsfor VDAC1

Transcriptsfor VDAC1

Expression for VDAC1

Orthologsfor VDAC1

Paralogsfor VDAC1

SNPs/Variantsfor VDAC1

Disorders & Mutationsfor VDAC1

Medical Newsfor VDAC1

Publicationsfor VDAC1

Search for VDAC1

Genome Databases showing VDAC1

Other Databases showing VDAC1

Specialized Databases showing VDAC1

Licensable Technologiesfor VDAC1

Servicesfor VDAC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VDAC1

Summaries
for VDAC1

Genomic Location
for VDAC1

Proteins
for VDAC1

Protein Domains/
Families
for VDAC1

Gene Function
for VDAC1

Pathways & Interactions
for VDAC1

Drugs & Compounds
for VDAC1

Transcripts
for VDAC1

Expression
for VDAC1

Orthologs
for VDAC1

Paralogs
for VDAC1

SNPs/Variants
for VDAC1

Disorders & Mutations
for VDAC1

Medical News
for VDAC1

Publications
for VDAC1

Licensable Technologies
for VDAC1

Services
for VDAC1