VDAC1 Gene
protein-coding GIFtS: 61
GCID: GC05M133307
|
|
voltage-dependent anion channel 1
| |
Aliases for VDAC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Voltage-Dependent Anion Channel 11 2 | | VDAC-12 3 | | PORIN1 2 | | MGC1110641 | | Outer Mitochondrial Membrane Protein Porin 12 3 | | Voltage-Dependent Anion-Selective Channel Protein 12 | | Plasmalemmal Porin2 3 | | VDAC3 | | Porin 31HL2 3 | | HVDAC11 | | Porin 31HM2 3 | | |
Export aliases for VDAC1 gene to outside databasesPrevious GC identifers: GC05M132956 GC05M133821 GC05M133338 GC05M133383 GC05M133336 GC05M128492 |
Summaries for VDAC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for VDAC1: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrialmembrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membraneand may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involvedin transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenesof this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.(provided by RefSeq, Sep 2010) UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at theouter mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved incell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closedconformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state iscation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible forthe release of mitochondrial products that triggers apoptosis Gene Wiki entry for VDAC1
|
Genomic Views for VDAC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VDAC1 gene promoter: Bach1 SRY POU2F1 Pax-5 AP-1 POU2F1a ATF-2 MyoD c-Jun YY1 Other transcription factors
Search SABiosciences Chromatin IP Primers for VDAC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VDAC1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31VDAC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M133307: view genomic region
(about GC identifiers)
Start:
|
133,307,606 bp from pter |
End:
|
133,340,824 bp from pter |
Size:
|
33,219 bases |
Orientation:
|
minus strand |
|
Proteins for VDAC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796 (See
protein sequence)Recommended Name: Voltage-dependent anion-selective channel protein 1 Size: 283 amino acids; 30773 Da
Subunit: Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with BOP/C22orf29 (via BH3domain). Interacts with influenza A virus PB1-F2 protein
Subcellular location: Mitochondrion outer membrane. Cell membrane
2 PDB 3D structures from and Proteopedia for VDAC1:2JK4 (3D)
  2K4T (3D)
 
Secondary accessions: B3KVK4 D3DQ93 Q5FVE7 Q9UIQ5 Q9UPL0Explore the universe of human proteins at neXtProt for VDAC1: NX_P21796
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21796 VDAC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003365.1 ENSEMBL proteins: ENSP00000265333 ENSP00000378484 ENSP00000378487 ENSP00000390129 Reactome Protein details: P21796 Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
VDAC1 for ontologies About GeneDecksing
VDAC1 Antibody Products: Assay Products for VDAC1: |
Protein
Domains / Families for VDAC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VDAC1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21796ProtoNet protein and cluster: P21796 1 Blocks protein family: IPB001925 Porin
UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Domain: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds backinto the pore opening and plays a role in voltage-gated channel activitySimilarity: Belongs to the eukaryotic mitochondrial porin family |
Function for VDAC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at theouter mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved incell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closedconformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state iscation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible forthe release of mitochondrial products that triggers apoptosis Genatlas biochemistry entry for VDAC1:voltage-dependent anion selective channel 1,mitochondrial outer membrane,tissue specific (skeletal muscle),allowingdiffusion of small hydrophilic molecules
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VDAC1 (NM_003374) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VDAC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VDAC1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VDAC1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
VDAC1 for ontologies About GeneDecksing
Animal Models: Mouse knock-out Vdac1tm1Wjc for VDAC1 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vdac1):
VDAC1 for phenotypes About GeneDecksing
|
Pathways & Interactions for VDAC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts | | | 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 3 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | | | 4 | Cytoskeletal Signaling | | | 5 | Mitochondrial Protein Import | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for VDAC1 2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VDAC1 1
Cell Signaling Technology (CST) Pathway for VDAC1 1 GeneGo (Thomson Reuters) Pathway for VDAC1 2
Reactome Pathways for VDAC1 1 PharmGKB Pathway for VDAC1 4
Kegg Pathways (Kegg details for VDAC1):
VDAC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VDAC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/338 Interacting proteins for VDAC1 (P217961, 2, 3 ENSP000002653334) via UniProtKB, MINT, STRING, and/or I2D (see all 338)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HK1 | P193671, 2, 3 | EBI-354158,EBI-713162 MINT-8079030 I2D:
score=1 | | BAK1 | Q166112, 3, ENSP000003635914 | MINT-15123 MINT-15124 I2D:
score=4 STRING: ENSP00000363591 | | CKMT1B | P125322, 3, ENSP000003002834 | MINT-4054731 I2D:
score=2 STRING: ENSP00000300283 | | CKMT1A | P125322, 3 | MINT-4054731 I2D:
score=2 | | ACTB | P607092, 3, ENSP000003499604 | MINT-4054731 I2D:
score=1 STRING: ENSP00000349960 | About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
VDAC1 for ontologies About GeneDecksing
|
Drugs & Compounds for VDAC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
VDAC1 for compounds About GeneDecksing
Browse Tocris compounds for VDAC1
1 DrugBank Compound for VDAC1 About this table
10/103 Novoseek chemical compound relationships for VDAC1 gene (see all 103) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ptpc |
74.2 |
5 |
10620603 (1), 11175251 (1), 15377997 (1), 19693275 (1) (see all 5) |
| imipenem |
57.6 |
11 |
10698994 (2), 12604564 (2), 12589810 (1), 10952609 (1) (see all 9) |
| cefoxitin |
53.7 |
8 |
8834877 (2), 19686282 (1), 11034276 (1), 15668019 (1) (see all 5) |
| lipid |
52.4 |
65 |
17336328 (4), 7681063 (2), 8703976 (2), 10479618 (2) (see all 51) |
| cefepime |
51.7 |
3 |
10581197 (1), 9846735 (1), 15668019 (1) |
| atp |
51.5 |
47 |
7529026 (5), 16354668 (2), 20032281 (2), 20205711 (2) (see all 30) |
| ertapenem |
51.3 |
1 |
17576696 (1) |
| beta-lactam |
48.7 |
7 |
11454211 (1), 8314292 (1), 15155215 (1), 19434239 (1) (see all 5) |
| maltodextrin |
47.4 |
2 |
10074088 (1), 7925308 (1) |
| polymyxin b |
45.6 |
4 |
8567029 (1), 15155667 (1), 8380280 (1) |
Search CenterWatch for drugs/clinical trials and news about VDAC1 
|
Transcripts for VDAC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for VDAC1 gene: NM_003374.2 Unigene Cluster for VDAC1: Voltage-dependent anion channel 1 Hs.519320 [show with all ESTs]Unigene Representative Sequence: AK1229537 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265333(uc003kyr.2) ENST00000395044 ENST00000395047(uc003kyp.2 uc003kyq.2) ENST00000492324 ENST00000489906 ENST00000425992 ENST00000466080
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VDAC1 (NM_003374) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VDAC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VDAC1  |
Additional cDNA sequence: AK095989.1 AK122953.1 AK293639.1 BC008482.1 BC071168.1 BC090042.1 L06132.1 NR_036624.1 NR_036625.1 24/32 DOTS entries (see all 32): DT.97861572 DT.95273539 DT.451941 DT.95273565 DT.100880956 DT.120871794 DT.100880950 DT.121297354 DT.40129022 DT.95273540 DT.120871767 DT.92460271 DT.100032191 DT.100829458 DT.121318065 DT.120871745 DT.86841159 DT.100880947 DT.100880949 DT.100880957 DT.120871717 DT.92460223 DT.97798688 DT.97856586 24/825 AceView cDNA sequences (see all 825): BQ684780 CR623138 T08466 L06132 BE272810 CB135784 AA313735 CA414636 CR623923 BM844974 BE887494 AL548202 CB154545 AU104463 CR606302 BQ232172 CB149386 BM844046 BI253305 BE294537 BG251061 BM665270 BI335741 CB130056 GeneLoc Exon Structure
|
Expression for VDAC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VDAC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTGACAACAC
About this image See VDAC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VDAC1
SOURCE GeneReport for Unigene cluster: Hs.519320 UniProtKB/Swiss-Prot: VDAC1_HUMAN, P21796Tissue specificity: Heart, liver and skeletal muscle SABiosciences Expression via Pathway-Focused PCR Arrays including VDAC1:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VDAC1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VDAC1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VDAC1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VDAC1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VDAC1 |
Orthologs for VDAC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VDAC1 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Vdac11 , 5 |
voltage-dependent anion channel 11, 5 |
89.87(n)1 98.59(a)1 |
  |
11 (31.86 cM)5 223331 NM_011694.41 NP_035824.11 523608605 |
chicken (Gallus gallus) |
Aves |
VDAC11 |
voltage-dependent anion channel 1 |
84.69(n) 95.41(a) |
  |
416320 NM_001033869.1 NP_001029041.1 |
lizard (Anolis carolinensis) |
Reptilia |
VDAC16 |
-- |
90(a) |
1 ↔ 1 |
2(130560180-130577513) |
African clawed frog (Xenopus laevis) |
Amphibia |
vdac1-prov2 |
voltage-dependent anion channel 1 |
78.83(n) |
  |
BC046577.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.281732 |
Danio rerio clone RK078A3F07 voltage-dependent anion more |
79.47(n) |
  |
AY398429.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
porin3 |
mitochondrial transport voltage-dependent ion-selective more |
58(a) (best of 2) |
  |
32B1 -- |
worm (Caenorhabditis elegans) |
Secernentea |
R05G6.73 |
Channel Protein |
40(a) |
  |
IV(7506758-7507930) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
VDAC46VDAC16(see all 6) |
mitochondrial outer membrane protein porin 1(see all 6) |
23(a)22(a)(see all 6) |
many ↔ manymany ↔ many(see all 6) |
5(23283680-23285934) 3(85601-87858) |
rice (Oryza sativa) |
Liliopsida |
----(see all 5) |
outer mitochondrial membrane porin, putative, expr...outer mitochondrial membrane porin, putative, expr...(see all 5) |
24(a)24(a)(see all 5) |
many ↔ manymany ↔ many(see all 5) |
1(22907136-22909643) 5(26565524-26569025) |
ENSEMBL Gene Tree for VDAC1 (if available) TreeFam Gene Tree for VDAC1 (if available)  |
Paralogs for VDAC1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for VDAC1 gene
- VDAC22 VDAC32
2 SIMAP similar genes for VDAC1 using alignment to 3 protein entries: VDAC1_HUMAN (see all proteins):VDAC2 VDAC3
VDAC1 for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for VDAC1 (see all 11) PGOHUM00000242159 PGOHUM00000239465 PGOHUM00000248358 PGOHUM00000245106 PGOHUM00000245206
|
Genomic Variants for VDAC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for VDAC1 (133307606 - 133340824 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for VDAC1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VDAC1 |
|
Disorders
/ Diseases for VDAC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VDAC1 for disorders About GeneDecksing
OMIM gene information: 604492
OMIM disorders: --
20/57 diseases for VDAC1 (see all 57): About MalaCardsallan-herndon-dudley syndrome disseminated intravascular coagulation mixed connective tissue disease connective tissue disease typhoid fever gonorrhea klebsiella haemophilus influenzae cystic fibrosis male infertility gastroenteritis morbid obesity hypertrophic cardiomyopathy acute lymphoblastic leukemia chronic lymphocytic leukemia lymphoblastic leukemia lyme disease lymphocytic leukemia ulcerative colitis encephalomyopathy
10/22 Novoseek disease relationships for VDAC1 gene (see all 22) About this table
Human Genome Epidemiology (HuGE) Navigator: VDAC1 (3 documents) Export disorders for VDAC1 gene to outside databases
|
Publications for VDAC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VDAC1 gene, integrated from 9 sources (see all 475): (articles sorted by number of sources associating them with VDAC1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. (PubMed id 8420959)1, 2, 9 Blachly-Dyson E.... Forte M.A. (1993)
- Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical. (PubMed id 1657034)1, 2, 9 Juergens L.... Hilschmann N. (1991)
- Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. (PubMed id 7517385)1, 3, 9 Blachly-Dyson E.... Forte M. (1994)
- Subcellular localization of human voltage-dependent anion channel isoforms. (PubMed id 7539795)1, 2, 9 Yu W.H.... Forte M.A. (1995)
- Study of PTPC composition during apoptosis for identification of viral protein target. (PubMed id 15033708)1, 2, 9 Verrier F.... Brenner C. (2003)
- Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy? (PubMed id 11845315)1, 2, 9 Thinnes F.P.... Hilschmann N. (2001)
- Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. (PubMed id 18755977)1, 2 Hiller S....Wagner G. (2008)
- Structure of the human voltage-dependent anion channel. (PubMed id 18832158)1, 2 Bayrhuber M.... Zeth K. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PubMed id 16201016)1, 2 Zamarin D.... Palese P. (2005)
|
External Searches for VDAC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VDAC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VDAC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VDAC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Name | Description |
| PharmGKB entry for VDAC1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for VDAC1 gene: Search GeneIP for patents involving VDAC1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for VDAC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for VDAC1 | | OriGene shRNA RFP for VDAC1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VDAC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VDAC1 | | OriGene Protein Over-expression Lysate for VDAC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for VDAC1 | | OriGene 3'-UTR Clone for VDAC1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VDAC1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for VDAC1 | | OriGene Custom Protein Services for VDAC1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VDAC1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VDAC1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VDAC1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VDAC1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VDAC1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VDAC1 |
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| Antibodies & Assays for VDAC1  |
| | | Search Tocris compounds for VDAC1 |
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 | | VDAC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VDAC1 |
|  |  |  | | | ThermoFisher Antibody for VDAC1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VDAC1 |
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