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Aliases for VCY1B Gene

Aliases for VCY1B Gene

  • Variable Charge, Y-Linked 1B 2 3
  • Variably Charged Protein Y 3 4
  • Basic Charge, Y-Linked 1 3 4
  • BPY1B 3 4
  • Testis-Specific Basic Protein On Y, 1 3
  • Testis-Specific Basic Protein Y 1 3
  • Basic Protein On Y Chromosome, 1 3
  • VCY VCY1B 4
  • VCY1A 4
  • BPY1 4

External Ids for VCY1B Gene

Previous GeneCards Identifiers for VCY1B Gene

  • GC0YP014606
  • GC0YU900269
  • GC0YM014607
  • GC0YM016097
  • GC0YP016170

Summaries for VCY1B Gene

Entrez Gene Summary for VCY1B Gene

  • The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. [provided by RefSeq, Jul 2008]

GeneCards Summary for VCY1B Gene

VCY1B (Variable Charge, Y-Linked 1B) is a Protein Coding gene. An important paralog of this gene is VCY.

UniProtKB/Swiss-Prot for VCY1B Gene

  • May mediate a process in spermatogenesis or may play a role in sex ratio distortion

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCY1B Gene

Genomics for VCY1B Gene

Regulatory Elements for VCY1B Gene

Genomic Location for VCY1B Gene

14,056,217 bp from pter
14,056,958 bp from pter
742 bases
Plus strand

Genomic View for VCY1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCY1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCY1B Gene

Proteins for VCY1B Gene

  • Protein details for VCY1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific basic protein Y 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for VCY1B Gene

    125 amino acids
    Molecular mass:
    12917 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VCY1B Gene

Proteomics data for VCY1B Gene at MOPED

Post-translational modifications for VCY1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VCY1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCY1B Gene

Domains for VCY1B Gene

Protein Domains for VCY1B Gene


Suggested Antigen Peptide Sequences for VCY1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O14598
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with VCY1B: view

No data available for Gene Families for VCY1B Gene

Function for VCY1B Gene

Molecular function for VCY1B Gene

UniProtKB/Swiss-Prot Function:
May mediate a process in spermatogenesis or may play a role in sex ratio distortion

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCY1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VCY1B Gene

Localization for VCY1B Gene

Subcellular locations from

Jensen Localization Image for VCY1B Gene COMPARTMENTS Subcellular localization image for VCY1B gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VCY1B Gene

Pathways for VCY1B Gene

SuperPathways for VCY1B Gene

No Data Available

Interacting Proteins for VCY1B Gene

Gene Ontology (GO) - Biological Process for VCY1B Gene


No data available for Pathways by source for VCY1B Gene

Transcripts for VCY1B Gene

mRNA/cDNA for VCY1B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCY1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCY1B Gene

No ASD Table

Relevant External Links for VCY1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VCY1B Gene

mRNA expression in normal human tissues for VCY1B Gene

Protein differential expression in normal tissues for VCY1B Gene

This gene is overexpressed in Ovary (38.6) and Testis (30.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VCY1B Gene

mRNA Expression by UniProt/SwissProt for VCY1B Gene

Tissue specificity: Expressed exclusively in testis
genes like me logo Genes that share expressions with VCY1B: view

Expression partners for VCY1B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VCY1B Gene

Orthologs for VCY1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for VCY1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC742075 35
  • 95.69 (n)
  • 88.79 (a)
Species with no ortholog for VCY1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VCY1B Gene

Gene Tree for VCY1B (if available)
Gene Tree for VCY1B (if available)

Paralogs for VCY1B Gene

Paralogs for VCY1B Gene

Selected SIMAP similar genes for VCY1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VCY1B: view

Variants for VCY1B Gene

Sequence variations from dbSNP and Humsavar for VCY1B Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs13304926 -- 14,056,247(+) AGGCA(G/T)CCTGG utr-variant-5-prime
rs113280232 -- 14,056,919(+) TGCTT(C/G)CCATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VCY1B Gene

Variant ID Type Subtype PubMed ID
nsv469834 CNV Gain 16826518

Relevant External Links for VCY1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCY1B Gene

Disorders for VCY1B Gene

(1) University of Copenhagen DISEASES for VCY1B Gene

genes like me logo Genes that share disorders with VCY1B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for VCY1B Gene

Publications for VCY1B Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 3 4
  2. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for VCY1B Gene

Sources for VCY1B Gene

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