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VCY Gene

protein-coding   GIFtS: 37

GC0YP014607
variable charge, Y-linked
(Previous names: variable charge, Y chromosome )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BPY1 1, 2, 3, 5
BPY1B 3
MGC119817 2
VCY1 1, 2
VCY1A 1, 2, 3
Descriptions
Basic charge, Y-linked 1 3
Variably charged protein Y 3
basic protein on Y chromosome, 1 2
testis-specific basic protein on Y, 1 2
variable charge, Y chromosome 1, 2
variable charge, Y-linked 2
External Ids
HGNC: 126681
Entrez Gene: 90842
UniProtKB: O145983
Ensembl: ENSG000001298627
Search outside databases for aliases for VCY gene

Previous GC identifers: GC0YP015485 GC0YM015407 GC0YM015106

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VCY:
The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has
multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ
cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception
that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked
members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene
encodes a small, positively charged protein. The presence of a putative bipartite nuclear
localization signal suggests that this gene encodes a nuclear protein. The genome has two
identical copies of this gene within a palindromic region; this record represents the more
centromeric copy. [provided by RefSeq]

UniProtKB/Swiss-Prot: VCY1_HUMAN, O14598
Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VCY gene  

Entrez Gene cytogenetic band: Yq11.221   Ensembl cytogenetic band:  Yq11.221   HGNC cytogenetic band: Yq11.221

VCY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP014607:     (about GC identifiers)

Start:
14,677,492 bp from pter
End:
14,678,234 bp from pter
Size:
743 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000024.8  NT_011875.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VCY1_HUMAN, O14598 (See protein sequence)
Recommended Name: Testis-specific basic protein Y 1  
Size: 125 amino acids; 12917 Da

REFSEQ proteins: NP_004670.1  

ENSEMBL proteins: 
ENSP00000250823 


Human Recombinant Proteins 
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for VCY: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for VCY

Assays for VCY: 
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Browse Kits and Assays available from Millipore
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O14598

UniProtKB/Swiss-Prot: VCY1_HUMAN, O14598
Similarity: Belongs to the VCX/VCY family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VCY)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004679

              Applied Biosystems Silencer® siRNAs for VCY

              Sigma-Aldrich siRNA for VCY  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for VCY
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004679
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004679
                                 untagged cDNA clone in CMV expression vector: NM_004679 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004679

UniProtKB/Swiss-Prot: VCY1_HUMAN, O14598
Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion

Genatlas biochemistry entry for VCY:
variable charge X/Y,basic protein on chromosome Y,1,testis specific,in a AZF deleted region
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VCY

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VCY)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004679

              Sigma-Aldrich siRNA for VCY  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004679  

REFSEQ mRNAs for VCY gene: 

NM_004679.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004679  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004679
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004679
                                 untagged cDNA clone in CMV expression vector: NM_004679 

Additional cDNA sequence: 

AF000979.1 BC096729.1 

2 DOTS entries:

DT.120654203  DT.443460 

24/43 AceView cDNA sequences (see all 43 ):

BF508070 AF000979 AI650513 BF478074 AI917448 AW193704 NM_181880 BF059317 
AI672566 AI634041 AA759284 AI917301 BC056508 NM_004679 AA496066 AI809663 
AW196662 AI809702 AI621240 AA393129 AI611655 BX281130 AW303648 AI963982 

highest scoring ESTs for VCY:

AF000979 AA609921 AI149997 NM_004679 BC096729 AI633259 XM_379695 AA406064 AA621737 AA635143 

Unigene Cluster for VCY:

Variable charge, Y-linked
Hs.632284  [show with all ESTs]
Unigene Representative Sequence: AF000979


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000250823  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VCY expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for VCY

1 / 2 / 3

3 probe-sets matching VCY gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

32677_at2, 3 U95-A 8 1.00 0.29 1.00 1.00 AF000979 1.00 0.80 0.91 1

206922_at2, 3 U133-A 4 1.00 0.34 -- -- NM_004679 0.60 1.00 0.82 1

206922_at2 U133Plus2 4 1.00 0.34 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.632284

Expression variation in blood from EXPOLDB for VCY

UniProtKB/Swiss-Prot: VCY1_HUMAN, O14598
Tissue specificity: Expressed exclusively in testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for VCY
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for VCY gene
VCY1B1 2  VCX3B2  VCX2  VCX22  VCX3A2  ENSG000002149502  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 400012

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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6 PubMed articles for VCY gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9084 HGNC: 12668 AceView: VCY.1 Ensembl:ENSG00000129862 euGenes: HUgn9084
ECgene: VCY H-InvDB: VCY
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for VCY:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VCY-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for VCY Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Tocris compounds for VCY




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for VCY

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