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Aliases for VCX2 Gene

Aliases for VCX2 Gene

  • Variable Charge, X-Linked 2 2 3
  • VCX2R 3 4 6
  • VCXB 3 4 6
  • Variable Charge Protein On X With Two Repeats 3 4
  • Variably Charged Protein X-B 3 4
  • VCX-2r 3 4
  • Variably Charged, X Chromosome, With 2 Repeats 3
  • Variable Charge X-Linked Protein 2 3
  • Variably Charged, X Chromosome 2 3
  • Variably Charged, X Chromosome B 3
  • VCX-B 4

External Ids for VCX2 Gene

Previous GeneCards Identifiers for VCX2 Gene

  • GC0XM007550
  • GC0XM007947
  • GC0XM005966

Summaries for VCX2 Gene

Entrez Gene Summary for VCX2 Gene

  • This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes that are expressed exclusively in male germ cells. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This gene contains two copies of a 30 nt tandem repeat. Deletion of a nearby member of this family was implicated in mental retardation. [provided by RefSeq, Feb 2015]

GeneCards Summary for VCX2 Gene

VCX2 (Variable Charge, X-Linked 2) is a Protein Coding gene. An important paralog of this gene is VCY1B.

UniProtKB/Swiss-Prot for VCX2 Gene

  • May mediate a process in spermatogenesis or may play a role in sex ratio distortion

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCX2 Gene

Genomics for VCX2 Gene

Regulatory Elements for VCX2 Gene

Genomic Location for VCX2 Gene

8,169,944 bp from pter
8,171,267 bp from pter
1,324 bases
Minus strand

Genomic View for VCX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCX2 Gene

Proteins for VCX2 Gene

  • Protein details for VCX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Variable charge X-linked protein 2
    Protein Accession:
    Secondary Accessions:
    • A3KPB6
    • Q4V9T2
    • Q9P0H5

    Protein attributes for VCX2 Gene

    139 amino acids
    Molecular mass:
    14661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VCX2 Gene

Proteomics data for VCX2 Gene at MOPED

Post-translational modifications for VCX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VCX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCX2 Gene

Domains for VCX2 Gene

Protein Domains for VCX2 Gene


Suggested Antigen Peptide Sequences for VCX2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H322
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with VCX2: view

No data available for Gene Families for VCX2 Gene

Function for VCX2 Gene

Molecular function for VCX2 Gene

UniProtKB/Swiss-Prot Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion

Gene Ontology (GO) - Molecular Function for VCX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VCX2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VCX2 Gene

Localization for VCX2 Gene

Subcellular locations from

Jensen Localization Image for VCX2 Gene COMPARTMENTS Subcellular localization image for VCX2 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VCX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with VCX2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VCX2 Gene

Pathways for VCX2 Gene

SuperPathways for VCX2 Gene

No Data Available

Interacting Proteins for VCX2 Gene

Gene Ontology (GO) - Biological Process for VCX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with VCX2: view

No data available for Pathways by source for VCX2 Gene

Transcripts for VCX2 Gene

mRNA/cDNA for VCX2 Gene

(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VCX2 Gene

Variable charge, X-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VCX2 Gene

No ASD Table

Relevant External Links for VCX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VCX2 Gene

mRNA expression in normal human tissues for VCX2 Gene

mRNA differential expression in normal tissues according to GTEx for VCX2 Gene

This gene is overexpressed in Testis (52.7).

SOURCE GeneReport for Unigene cluster for VCX2 Gene Hs.279737

mRNA Expression by UniProt/SwissProt for VCX2 Gene

Tissue specificity: Expressed exclusively in testis
genes like me logo Genes that share expressions with VCX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for VCX2 Gene

Orthologs for VCX2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for VCX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC742075 35
  • 95.66 (n)
  • 91.87 (a)
VCX2 36
  • 87 (a)
Species with no ortholog for VCX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VCX2 Gene

Gene Tree for VCX2 (if available)
Gene Tree for VCX2 (if available)

Paralogs for VCX2 Gene

Paralogs for VCX2 Gene

Selected SIMAP similar genes for VCX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VCX2: view

Variants for VCX2 Gene

Sequence variations from dbSNP and Humsavar for VCX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1058237 - 8,170,124(-) GCGAG(C/G)TGGAA missense, reference
rs1058238 -- 8,170,119(-) GTGGA(A/G)GAACC reference, synonymous-codon
rs1058239 - 8,170,039(-) GAGCA(C/G)CGACT reference, missense
rs1622673 -- 8,170,786(+) ATGGT(A/C)GCCCT utr-variant-5-prime
rs1869586 -- 8,171,540(-) TGAGT(C/G)AATGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VCX2 Gene

Variant ID Type Subtype PubMed ID
dgv499n21 CNV Gain 19592680
nsv470340 CNV Gain 18288195
esv2752335 CNV Gain 17911159
nsv524164 CNV Gain 19592680
nsv528203 CNV Gain 19592680
nsv511081 CNV Complex 20534489
nsv6788 CNV Insertion 18451855
nsv508752 CNV Insertion 20534489

Relevant External Links for VCX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCX2 Gene

Disorders for VCX2 Gene

(2) University of Copenhagen DISEASES for VCX2 Gene

Relevant External Links for VCX2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with VCX2: view

No data available for UniProtKB/Swiss-Prot for VCX2 Gene

Publications for VCX2 Gene

  1. A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. (PMID: 10607842) Lahn B.T. … Page D.C. (Hum. Mol. Genet. 2000) 2 3 4
  2. A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. (PMID: 10903929) Fukami M. … Rappold G.A. (Am. J. Hum. Genet. 2000) 3 4
  3. Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis. (PMID: 18076704) Cuevas-Covarrubias S.A. … GonzA!lez-Huerta L.M. (Br. J. Dermatol. 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 48

Products for VCX2 Gene

Sources for VCX2 Gene

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