Aliases for VCX2 Gene
Aliases for VCX2 Gene
External Ids for VCX2 Gene
- HGNC: 18158
- Entrez Gene: 51480
- Ensembl: ENSG00000177504
- OMIM: 300532
- UniProtKB: Q9H322
Previous GeneCards Identifiers for VCX2 Gene
- GC0XM007550
- GC0XM007947
- GC0XM005966
Summaries for VCX2 Gene
-
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes that are expressed exclusively in male germ cells. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This gene contains two copies of a 30 nt tandem repeat. Deletion of a nearby member of this family was implicated in cognitive disability. [provided by RefSeq, Feb 2015]
GeneCards Summary for VCX2 Gene
VCX2 (Variable Charge, X-Linked 2) is a Protein Coding gene. Diseases associated with VCX2 include Ichthyosis, X-Linked. An important paralog of this gene is VCX.
UniProtKB/Swiss-Prot for VCX2 Gene
-
May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCX2 Gene
Genomics for VCX2 Gene
GeneHancer (GH) Regulatory Elements for VCX2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI008170 | Promoter | 0.5 | EPDnew | 550.8 | +0.6 | 571 | 0.1 | VCX2 GC0XP008127 | ||
GH0XI008191 | Enhancer | 0.6 | ENCODE | 0.4 | -19.9 | -19898 | 0.2 | SMARCE1 MAZ DPF2 MNT FOXA1 CTBP1 GATA3 JUND CREB1 FOS | MIR651 VCX2 PIR50074 | |
GH0XI008204 | Enhancer | 0.4 | ENCODE | 0.3 | -33.2 | -33168 | 0.2 | GATA3 TCF7L2 | VCX3B VCX2 PIR50074 | |
GH0XI008201 | Enhancer | 0.2 | ENCODE | 0.3 | -30.7 | -30724 | 1.4 | VCX2 PIR50074 | ||
GH0XI008273 | Enhancer | 0.6 | ENCODE | 0.1 | -102.4 | -102428 | 0.2 | JUN USF2 CEBPB EP300 RFX5 GATA3 JUND STAT3 RCOR1 FOS | VCX2 PIR50074 |
Regulatory Element Products
Genomic Locations for VCX2 Gene
- chrX:8,169,944-8,171,267
- (GRCh38/hg38)
- Size:
- 1,324 bases
- Orientation:
- Minus strand
- chrX:8,137,985-8,139,308
- (GRCh37/hg19)
Genomic View for VCX2 Gene
- Cytogenetic band:
-
- Xp22.31 by Ensembl
- Xp22.31 by Entrez Gene
- Xp22.31 by HGNC


RefSeq DNA sequence for VCX2 Gene
Proteins for VCX2 Gene
-
Protein details for VCX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H322-VCX2_HUMAN
- Recommended name:
- Variable charge X-linked protein 2
- Protein Accession:
- Q9H322
- A3KPB6
- Q4V9T2
- Q9P0H5
Protein attributes for VCX2 Gene
- Size:
- 139 amino acids
- Molecular mass:
- 14661 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for VCX2 Gene
Other Protein References for VCX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for VCX2
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- antibodies-online: Search results for available VCX2 related products ranked by validation data
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Protein Products
-
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- antibodies-online: Search results for 2 available VCX2 Proteins ranked by validation data
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-
Quality Products:
- Search GeneTex for Proteins for VCX2
Assay Products
- antibodies-online: Search results for available VCX2 related products ranked by validation data
No data available for DME Specific Peptides for VCX2 Gene
Domains & Families for VCX2 Gene
Gene Families for VCX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for VCX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H322- Family:
-
- Belongs to the VCX/VCY family.
Function for VCX2 Gene
Molecular function for VCX2 Gene
- UniProtKB/Swiss-Prot Function:
- May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
Phenotypes for VCX2 Gene
- GenomeRNAi human phenotypes for VCX2:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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- Overview of 45 available VCX2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCX2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VCX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VCX2
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VCX2 Gene
Localization for VCX2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VCX2 Gene
Pathways & Interactions for VCX2 Gene
Interacting Proteins for VCX2 Gene
Symbol | External ID(s) | Details |
---|---|---|
STS |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007420 | brain development | IBA | -- |
GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for VCX2 Gene
Transcripts for VCX2 Gene
mRNA/cDNA for VCX2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VCX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VCX2
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCX2
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miRNA Products
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Inhibitory RNA Products
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- Overview of 45 available VCX2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCX2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VCX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VCX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for VCX2 Gene
mRNA differential expression in normal tissues according to GTEx for VCX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of VCX2 Gene:
VCX2SOURCE GeneReport for Unigene cluster for VCX2 Gene:
Hs.279737mRNA Expression by UniProt/SwissProt for VCX2 Gene:
Q9H322-VCX2_HUMANPrimer Products
-
OriGene qPCR primer pairs for VCX2
- genomics-online: primer clones - Search results for 45 available VCX2 gene related products
- Overview of 45 available VCX2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCX2 Gene
Orthologs for VCX2 Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LOC742075 33 |
|
||
VCX2 34 |
|
OneToOne |
- Species where no ortholog for VCX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for VCX2 Gene
Variants for VCX2 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1008750347 | -- | 8,171,279(-) | A/G | upstream_transcript_variant | |
rs1008781271 | -- | 8,171,688(-) | G/A | upstream_transcript_variant | |
rs1013220331 | -- | 8,172,368(-) | T/C | upstream_transcript_variant | |
rs1013299039 | -- | 8,172,553(-) | A/G | upstream_transcript_variant | |
rs1013380752 | -- | 8,170,867(-) | /C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2214e212 | CNV | gain | 25503493 |
dgv4208n106 | CNV | deletion | 24896259 |
dgv499n21 | CNV | gain | 19592680 |
esv2752335 | CNV | gain | 17911159 |
esv3576759 | CNV | gain | 25503493 |
nsv470340 | CNV | gain | 18288195 |
nsv508752 | CNV | insertion | 20534489 |
nsv511081 | OTHER | complex | 20534489 |
nsv524164 | CNV | gain | 19592680 |
nsv528203 | CNV | gain | 19592680 |
nsv6788 | CNV | insertion | 18451855 |
Additional Variant Information for VCX2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCX2 Gene
Disorders for VCX2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
ichthyosis, x-linked |
|
|
Additional Disease Information for VCX2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for VCX2 Gene
Publications for VCX2 Gene
- A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. (PMID: 10607842) Lahn BT … Page DC (Human molecular genetics 2000) 2 3 4 58
- Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis. (PMID: 18076704) Cuevas-Covarrubias SA … González-Huerta LM (The British journal of dermatology 2008) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. (PMID: 10903929) Fukami M … Rappold GA (American journal of human genetics 2000) 3 4 58
- A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 44 58
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- Invitrogen Antibodies for VCX2
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available VCX2 related products ranked by validation data
- antibodies-online: Search results for available VCX2 related products ranked by validation data
- antibodies-online: Search results for 2 available VCX2 Proteins ranked by validation data
- Compare Top VCX2 Proteins
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Sources for VCX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew