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Aliases for VCX Gene

Aliases for VCX Gene

  • Variable Charge, X-Linked 2 3
  • VCX10R 3 4 6
  • VCXB1 3 4 6
  • Variable Charge Protein On X With Ten Repeats 3 4
  • Variable Charge, X Chromosome 2 3
  • Variably Charged Protein X-B1 3 4
  • VCX-10r 3 4
  • VCX-B1 3 4
  • VCX1 3 4
  • Variable Charge X-Linked Protein 1 3

External Ids for VCX Gene

Previous GeneCards Identifiers for VCX Gene

  • GC0XP006659
  • GC0XP007169
  • GC0XP007221
  • GC0XP007620
  • GC0XP007770
  • GC0XP005618

Summaries for VCX Gene

Entrez Gene Summary for VCX Gene

  • This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

GeneCards Summary for VCX Gene

VCX (Variable Charge, X-Linked) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is VCY1B.

UniProtKB/Swiss-Prot for VCX Gene

  • May mediate a process in spermatogenesis or may play a role in sex ratio distortion

Gene Wiki entry for VCX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCX Gene

Genomics for VCX Gene

Regulatory Elements for VCX Gene

Genomic Location for VCX Gene

Start:
7,842,262 bp from pter
End:
7,844,143 bp from pter
Size:
1,882 bases
Orientation:
Plus strand

Genomic View for VCX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCX Gene

Proteins for VCX Gene

  • Protein details for VCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H320-VCX1_HUMAN
    Recommended name:
    Variable charge X-linked protein 1
    Protein Accession:
    Q9H320
    Secondary Accessions:
    • A0JNS5
    • Q4V774
    • Q9P0H3

    Protein attributes for VCX Gene

    Size:
    206 amino acids
    Molecular mass:
    22289 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VCX Gene

Proteomics data for VCX Gene at MOPED

Post-translational modifications for VCX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCX Gene

Domains for VCX Gene

Protein Domains for VCX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VCX Gene

Graphical View of Domain Structure for InterPro Entry

Q9H320

UniProtKB/Swiss-Prot:

VCX1_HUMAN :
  • Q9H320
Family:
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with VCX: view

No data available for Gene Families for VCX Gene

Function for VCX Gene

Molecular function for VCX Gene

GENATLAS Biochemistry: basic protein variable charge X/Y on chromosome X,testis specific,most likely present in germ cells,included in the CRI-S232 sequence flanking the STS gene
UniProtKB/Swiss-Prot Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion

Gene Ontology (GO) - Molecular Function for VCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 12862317
genes like me logo Genes that share ontologies with VCX: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VCX Gene

Localization for VCX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VCX Gene COMPARTMENTS Subcellular localization image for VCX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for VCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12862317
GO:0005730 nucleolus IDA 12862317
genes like me logo Genes that share ontologies with VCX: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VCX Gene

Pathways for VCX Gene

SuperPathways for VCX Gene

No Data Available

Interacting Proteins for VCX Gene

Gene Ontology (GO) - Biological Process for VCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS 12862317
GO:0007283 spermatogenesis TAS 10607842
GO:0042255 ribosome assembly NAS 12862317
genes like me logo Genes that share ontologies with VCX: view

No data available for Pathways by source for VCX Gene

Transcripts for VCX Gene

mRNA/cDNA for VCX Gene

(11) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VCX Gene

Variable charge, X-linked:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VCX
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCX Gene

No ASD Table

Relevant External Links for VCX Gene

GeneLoc Exon Structure for
VCX
ECgene alternative splicing isoforms for
VCX

Expression for VCX Gene

mRNA expression in normal human tissues for VCX Gene

mRNA differential expression in normal tissues according to GTEx for VCX Gene

This gene is overexpressed in Testis (45.2).

SOURCE GeneReport for Unigene cluster for VCX Gene Hs.567503

mRNA Expression by UniProt/SwissProt for VCX Gene

Q9H320-VCX1_HUMAN
Tissue specificity: Expressed exclusively in testis
genes like me logo Genes that share expressions with VCX: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for VCX Gene

Orthologs for VCX Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for VCX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
Species with no ortholog for VCX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VCX Gene

ENSEMBL:
Gene Tree for VCX (if available)
TreeFam:
Gene Tree for VCX (if available)

Paralogs for VCX Gene

Paralogs for VCX Gene

Selected SIMAP similar genes for VCX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VCX: view

Variants for VCX Gene

Sequence variations from dbSNP and Humsavar for VCX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1637790 -- 7,844,627(-) GTCCC(C/T)GTGAC downstream-variant-500B
rs1637791 -- 7,844,626(-) TCCCT(C/G)TGACC downstream-variant-500B
rs1637792 -- 7,843,783(-) CTCCA(C/G)CTGGC missense, reference
rs2529875 -- 7,842,871(-) TCCCC(A/G)TGTTC intron-variant
rs2529876 -- 7,842,759(-) TACCC(A/G)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VCX Gene

Variant ID Type Subtype PubMed ID
esv2422194 CNV Duplication 17116639
dgv499n21 CNV Gain 19592680
dgv1n30 CNV Gain 18288195
esv33658 CNV Loss 17666407

Relevant External Links for VCX Gene

HapMap Linkage Disequilibrium report
VCX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCX Gene

Disorders for VCX Gene

(3) University of Copenhagen DISEASES for VCX Gene

Relevant External Links for VCX

Genetic Association Database (GAD)
VCX
genes like me logo Genes that share disorders with VCX: view

No data available for UniProtKB/Swiss-Prot for VCX Gene

Publications for VCX Gene

  1. A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. (PMID: 10607842) Lahn B.T. … Page D.C. (Hum. Mol. Genet. 2000) 2 3 4
  2. A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. (PMID: 10903929) Fukami M. … Rappold G.A. (Am. J. Hum. Genet. 2000) 2 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. (PMID: 12826317) Sy S.M. … Yim A.P. (Lung Cancer 2003) 3
  5. Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. (PMID: 12862317) Zou S.W. … Wang L.F. (Cell Res. 2003) 3

Products for VCX Gene

Sources for VCX Gene

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