VCX Gene
protein-coding GIFtS: 45
GCID: GC0XP007770
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variable charge, X-linked(Previous names: variable charge, X chromosome )
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Aliases
for VCX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Variable Charge, X-Linked1 2 | | VCXB12 3 5 | | VCX10R1 2 3 5 | | Variable Charge, X Chromosome1 2 | | VCX-10r1 2 3 | | Variable Charge Protein On X With Ten Repeats2 3 | | VCX-B11 2 3 | | Variably Charged Protein X-B12 3 | | VCX11 2 3 | | Variable Charge X-Linked Protein 12 |
| External Ids: | HGNC: 126671 | Entrez Gene: 266092 | Ensembl: ENSG000001825837 | OMIM: 3002295 | UniProtKB: Q9H3203 |
|---|
| | ORGUL members: | |
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| NONCODE:n337625 | |
Export aliases for VCX gene to outside databasesPrevious GC identifers: GC0XP006659 GC0XP007169 GC0XP007221 GC0XP007620 GC0XP005618
Summaries
for VCX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VCX:
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all areexpressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked membersare two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree ofsequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only oncein Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have adifferent number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presenceof a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This genecontains 10 repeats of the 30-bp unit. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VCX1_HUMAN, Q9H320Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion
Gene Wiki entry for VCX
|
Genomic Views
for VCX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018934.1 NC_000023.10 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VCX gene promoter:
POU2F2 (Oct-2.1) oct-B2 oct-B3 POU2F2 POU2F2C POU2F1 POU2F1a NF-Y POU2F2B CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for VCX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VCX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.31 HGNC cytogenetic band: Xp22.31VCX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP007770: view genomic region
(about GC identifiers)
Start:
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7,810,303 bp from pter |
End:
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7,812,184 bp from pter |
Size:
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1,882 bases |
Orientation:
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plus strand |
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Proteins
for VCX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VCX1_HUMAN, Q9H320 (See
protein sequence)Recommended Name: Variable charge X-linked protein 1 Size: 206 amino acids; 22289 Da
Secondary accessions: Q9P0H3Explore the universe of human proteins at neXtProt for VCX: NX_Q9H320
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H320
VCX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_038480.2
ENSEMBL proteins: ENSP00000370447 ENSP00000344144
Human Recombinant Protein Products for VCX:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
VCX for ontologies About GeneDecksing
VCX Antibody Products:
Assay Products for VCX: |
Protein
Domains /
Families
for VCX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VCX for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H320ProtoNet protein and cluster: Q9H320 UniProtKB/Swiss-Prot: VCX1_HUMAN, Q9H320Similarity: Belongs to the VCX/VCY family |
Function
for VCX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: VCX1_HUMAN, Q9H320Function: May mediate a process in spermatogenesis or may play a role in sex ratio distortion Genatlas biochemistry entry for VCX:basic protein variable charge X/Y on chromosome X,testis specific,most likely present in germ cells,included in theCRI-S232 sequence flanking the STS gene
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
VCX for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCX
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VCX (NM_013452) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VCX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCX |
|
Pathways & Interactions
for VCX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VCX
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
VCX for ontologies About GeneDecksing
|
Drugs & Compounds
for VCX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VCX
Search CenterWatch for drugs/clinical trials and news about VCX / VCX1
|
Transcripts
for VCX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VCX gene: NM_013452.2 Unigene Cluster for VCX: Variable charge, X-linked Hs.567503 [show with all ESTs]Unigene Representative Sequence: AF1670812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381059(uc004crz.3) ENST00000341408
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCX
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VCX (NM_013452) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VCX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCX |
Additional cDNA sequence: AF159129.1 AF167081.2 BC098123.1 BC126903.1 2 DOTS entries: DT.313846 DT.313845 11 AceView cDNA sequences: AF167081 AA565702 NM_013452 AF159129 BE504628 AA206042 BF885187 AU099954 BV184446 AI824821 AA897187
GeneLoc Exon Structure
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Expression
for VCX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VCX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See VCX Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.567503
UniProtKB/Swiss-Prot: VCX1_HUMAN, Q9H320Tissue specificity: Expressed exclusively in testis
SABiosciences Custom PCR Arrays for VCX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VCX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat VCX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VCX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VCX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCX |
Orthologs
for VCX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for VCX (if available)
TreeFam Gene Tree for VCX (if available) |
Paralogs
for VCX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VCX gene
- VCX3A1 2 VCX3B1 2 VCY2 VCX22 VCY1B2
5 SIMAP similar genes for VCX using alignment to 4 protein entries: VCX1_HUMAN (see all proteins):VCX3B VCX3A VCY VCY1B VCX2
VCX for paralogs About GeneDecksing
|
Genomic Variants
for VCX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VCX (7810303 - 7812184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for VCX
9 CNVs: 83317 7798 83316 96450 96447 5361 96449 83315 34488 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VCX |
|
Disorders
/ Diseases
for VCX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VCX for disorders About GeneDecksing
OMIM gene information: 300229
OMIM disorders: --
8  diseases for VCX: About MalaCardsx-linked ichthyosis ocular albinism intellectual disability ichthyosis
kallmann syndrome albinism lung adenocarcinoma adenocarcinoma
3 diseases from the University of Copenhagen DISEASES database for VCX:X-linked ichthyosis Kallmann syndrome Ocular albinism Export disorders for VCX gene to outside databases
|
Publications
for VCX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VCX gene integrated from 9 sources:
(articles sorted by number of sources associating them with VCX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. (PubMed id 10903929)1, 2, 3 Fukami M.... Rappold G.A. (2000)
- A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. (PubMed id 10607842)1, 2, 3 Lahn B.T. and Page D.C. (2000)
- A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PubMed id 17342728)1 Hansen M.A....Leffers H. (2008)
- Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. (PubMed id 12862317)1 Zou S.W....Wang L.F. (2003)
- Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. (PubMed id 12826317)1 Sy S.M....Yim A.P. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular cytogenetic analysis of a familial interstitial deletion Xp22.2-22.3 with a highly variable phenotype in female carriers. (PubMed id 16470742)9 Chocholska S....Kehrer-Sawatzki H. (2006)
- Deletion of VCX-A due to NAHR plays a major role in the occurrence of mental retardation in patients with X-linked ichthyosis. (PubMed id 15888481)9 Van Esch H....Froyen G. (2005)
|
External Searches for VCX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VCX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VCX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VCX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VCX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VCX gene:
Search GeneIP for patents involving VCX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VCX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VCX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VCX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VCX | | | OriGene Protein Over-expression Lysate for VCX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VCX | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VCX | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VCX | | OriGene Custom Protein Services for VCX | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VCX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VCX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VCX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VCX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VCX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VCX |
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 |  |  |  | |
| | | | Search Tocris compounds for VCX |
| |  |  |  |  | | | | |
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 | | | VCX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCX |
|  |  |  |  | | | | ThermoFisher Antibodies for VCX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCX |
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