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Aliases for VCPKMT Gene

Aliases for VCPKMT Gene

  • Valosin Containing Protein Lysine (K) Methyltransferase 2 3
  • C14orf138 3 4 6
  • METTL21D 3 4 6
  • Valosin-Containing Protein Lysine Methyltransferase 3 4
  • Methyltransferase-Like Protein 21D 3 4
  • VCP Lysine Methyltransferase 3 4
  • Methyltransferase Like 21D 2 3
  • VCP-KMT 3 4
  • Protein-Lysine Methyltransferase METTL21D 3
  • Chromosome 14 Open Reading Frame 138 2
  • EC 2.1.1.- 4

External Ids for VCPKMT Gene

Previous Symbols for VCPKMT Gene

  • C14orf138
  • METTL21D

Summaries for VCPKMT Gene

GeneCards Summary for VCPKMT Gene

VCPKMT (Valosin Containing Protein Lysine (K) Methyltransferase) is a Protein Coding gene. GO annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is METTL21C.

UniProtKB/Swiss-Prot for VCPKMT Gene

  • Protein-lysine N-methyltransferase that specifically trimethylates Lys-315 of VCP/p97; this modification may decrease VCP ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCPKMT Gene

Genomics for VCPKMT Gene

Genomic Location for VCPKMT Gene

Start:
50,106,211 bp from pter
End:
50,116,600 bp from pter
Size:
10,390 bases
Orientation:
Minus strand

Genomic View for VCPKMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCPKMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCPKMT Gene

No data available for Regulatory Elements for VCPKMT Gene

Proteins for VCPKMT Gene

  • Protein details for VCPKMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H867-MT21D_HUMAN
    Recommended name:
    Protein-lysine methyltransferase METTL21D
    Protein Accession:
    Q9H867
    Secondary Accessions:
    • B7ZLA3
    • B7ZLA4
    • Q2M2X3
    • Q86T12

    Protein attributes for VCPKMT Gene

    Size:
    229 amino acids
    Molecular mass:
    25807 Da
    Quaternary structure:
    • Interacts with ALKBH6. Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation.
    SequenceCaution:
    • Sequence=CAD62329.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VCPKMT Gene

    Alternative splice isoforms for VCPKMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VCPKMT Gene

Proteomics data for VCPKMT Gene at MOPED

Post-translational modifications for VCPKMT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys122

Other Protein References for VCPKMT Gene

No data available for DME Specific Peptides for VCPKMT Gene

Domains for VCPKMT Gene

Protein Domains for VCPKMT Gene

Graphical View of Domain Structure for InterPro Entry

Q9H867

UniProtKB/Swiss-Prot:

MT21D_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.:
    • Q9H867
genes like me logo Genes that share domains with VCPKMT: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for VCPKMT Gene

Function for VCPKMT Gene

Molecular function for VCPKMT Gene

UniProtKB/Swiss-Prot Function: Protein-lysine N-methyltransferase that specifically trimethylates Lys-315 of VCP/p97; this modification may decrease VCP ATPase activity.

Enzyme Numbers (IUBMB) for VCPKMT Gene

Gene Ontology (GO) - Molecular Function for VCPKMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22948820
GO:0016279 protein-lysine N-methyltransferase activity IDA 22948820
genes like me logo Genes that share ontologies with VCPKMT: view

miRNA for VCPKMT Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VCPKMT Gene

Localization for VCPKMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCPKMT Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for VCPKMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with VCPKMT: view

No data available for Subcellular locations from COMPARTMENTS for VCPKMT Gene

Pathways for VCPKMT Gene

SuperPathways for VCPKMT Gene

No Data Available

Interacting Proteins for VCPKMT Gene

Gene Ontology (GO) - Biological Process for VCPKMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018023 peptidyl-lysine trimethylation IDA 22948820
genes like me logo Genes that share ontologies with VCPKMT: view

No data available for Pathways by source for VCPKMT Gene

Transcripts for VCPKMT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for VCPKMT Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for VCPKMT Gene

GeneLoc Exon Structure for
VCPKMT
ECgene alternative splicing isoforms for
VCPKMT

Expression for VCPKMT Gene

mRNA expression in normal human tissues for VCPKMT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VCPKMT Gene

genes like me logo Genes that share expressions with VCPKMT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VCPKMT Gene

Orthologs for VCPKMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VCPKMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21D 35
  • 100 (n)
  • 100 (a)
VCPKMT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL21D 35
  • 91.8 (n)
  • 94.26 (a)
VCPKMT 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL21D 35
  • 91.85 (n)
  • 94.32 (a)
VCPKMT 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl21d 16
Mettl21d 36
  • 90 (a)
OneToOne
Vcpkmt 35
  • 87.43 (n)
  • 89.91 (a)
oppossum
(Monodelphis domestica)
Mammalia VCPKMT 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCPKMT 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548559 35
  • 86.55 (n)
  • 87.28 (a)
chicken
(Gallus gallus)
Aves METTL21D 35
  • 66.67 (n)
  • 67.44 (a)
VCPKMT 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCPKMT 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15857 35
vcpkmt 35
  • 66.98 (n)
  • 66.05 (a)
zebrafish
(Danio rerio)
Actinopterygii vcpkmt 35
  • 61.05 (n)
  • 61.8 (a)
vcpkmt 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 35
  • 47.37 (n)
  • 36.84 (a)
C42C1.13 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73320 35
  • 48.82 (n)
  • 38.8 (a)
rice
(Oryza sativa)
Liliopsida Os06g0101100 35
  • 47.62 (n)
  • 36.51 (a)
Species with no ortholog for VCPKMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VCPKMT Gene

ENSEMBL:
Gene Tree for VCPKMT (if available)
TreeFam:
Gene Tree for VCPKMT (if available)

Paralogs for VCPKMT Gene

Paralogs for VCPKMT Gene

Selected SIMAP similar genes for VCPKMT Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for VCPKMT Gene

genes like me logo Genes that share paralogs with VCPKMT: view

Variants for VCPKMT Gene

Sequence variations from dbSNP and Humsavar for VCPKMT Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10844 -- 50,109,090(-) TACAT(A/G)TCTAT utr-variant-3-prime, nc-transcript-variant, intron-variant
rs13950 -- 50,109,103(+) GTGGA(A/G)GAAAA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1044751 -- 50,108,703(-) GAATT(C/T)TGGTA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1044754 -- 50,108,693(-) ATTTA(C/T)AGGCA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1474884 -- 50,116,203(+) TGAGG(C/T)GTAGG intron-variant, nc-transcript-variant

Relevant External Links for VCPKMT Gene

HapMap Linkage Disequilibrium report
VCPKMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VCPKMT Gene

Disorders for VCPKMT Gene

No disorders were found for VCPKMT Gene.

No data available for UniProtKB/Swiss-Prot for VCPKMT Gene

Publications for VCPKMT Gene

  1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 2 3 4
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for VCPKMT Gene

Sources for VCPKMT Gene

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