VCPKMT Gene

Aliases
for VCPKMT gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for VCPKMT gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for VCPKMT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VCPKMT

VCPKMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050577:  view genomic region     (about GC identifiers)

Proteins
for VCPKMT gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for VCPKMT:

4LG1 (3D)    

Explore the universe of human proteins at neXtProt for VCPKMT: NX_Q9H867

Explore proteomics data for VCPKMT at MOPED

Post-translational modifications: 

VCPKMT Human Recombinant Protein Products:

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	antibodies-online proteins for VCPKMT
	antibodies-online peptides for VCPKMT

VCPKMT Antibody Products:

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VCPKMT Assay Products:

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	antibodies-online kits for VCPKMT (2 products)

Domains /
Families
for VCPKMT gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9H867

Find genes that share domains with VCPKMT           About GenesLikeMe

Function
for VCPKMT gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 2.1.1.-¹

     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for VCPKMT

miRNA Products:		miRTarBase miRNAs that target VCPKMT: hsa-mir-130b-3p (MIRT020242), hsa-mir-30b-5p (MIRT023432), hsa-mir-331-3p (MIRT019242), hsa-mir-32-5p (MIRT028304)
		Block miRNA regulation of human, mouse, rat VCPKMT using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate VCPKMT
		SwitchGear 3'UTR luciferase reporter plasmid: VCPKMT 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for VCPKMT
		Predesigned siRNA for gene silencing in human, mouse, rat VCPKMT

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for VCPKMT

Clone Products:		OriGene clones in human, mouse for VCPKMT (see all 13) OriGene ORF clones in mouse, rat for VCPKMT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VCPKMT
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCPKMT

Localization
for VCPKMT gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for VCPKMT gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for VCPKMT gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for VCPKMT gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for VCPKMT gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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VCPKMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for VCPKMT OriGene qSTAR qPCR primer pairs in human, mouse for VCPKMT
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		QuantiFast Probe-based Assays in human, mouse, rat VCPKMT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCPKMT

Orthologs
for VCPKMT gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for VCPKMT gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for VCPKMT gene

METTL21B²  METTL21C²  METTL21A²  

1 SIMAP similar gene for VCPKMT using alignment to 1 protein entry:     MT21D_HUMAN:

METTL21A

Find genes that share paralogs with VCPKMT           About GenesLikeMe


1 Pseudogenes.org Pseudogene for VCPKMT
PGOHUM00000243970

Genomic Variants
for VCPKMT gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for VCPKMT (see all 269)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs114556351,2	C	--	50574928(+)	AAAAA-/A/A       A/AAAGAGAA	6	--	ds5001 cds1		1		NA	2
rs1177925491,2	F	--	50574930(+)	AAAAGA/GGAAAG	4	--	ds5001		1		NA	120
rs766245081,2	C	--	50575083(+)	AACAGC/TTAGCA	4	--	ds5001		5		NA CSA WA EA	362
rs608424621,2	C,F	--	50575110(+)	AAGCAC/TCACAG	4	--	ds5001		2		WA	120
rs71568711,2	C,F,H	--	50575160(+)	CTAAGG/AACAGT	4	--	ds5001		10		NS EA NA WA	1200
rs1175574011,2	F	--	50575199(+)	ACCAGC/GAAAGG	4	--	ds5001		1		NA	120
rs561917461,2	C,F	--	50575253(+)	TCTTGA/GCTTGT	4	--	ds5001		2		WA	120
rs796929001,2	C,F	--	50575280(+)	AATAGG/CGCTGC	4	--	ds5001		1		WA	118
rs171221341,2	C,F,H	--	50575302(+)	TTAACT/GGTTTA	4	--	ds5001		8		NA NS EA	672
rs1883254931,2		--	50575392(+)	ATGTAC/GCATCT	4	--	ut31 nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for VCPKMT (50575350 - 50583318 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for VCPKMT: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing VCPKMT

DNA2.0 Custom Variant and Variant Library Synthesis for VCPKMT

Disorders / Diseases
for VCPKMT gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for VCPKMT gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)^{1, 2, 3} Kernstock S.... Falnes P.O. (Nat. Commun. 2012)
2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)^{1, 2} Cloutier P.... Coulombe B. (PLoS Genet. 2013)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (Nature 2003)
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for VCPKMT gene

Genome Databases showing VCPKMT gene

Other Databases showing VCPKMT gene

Specialized Databases showing VCPKMT gene

Products
for VCPKMT gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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