Aliases for VCPKMT Gene
Aliases for VCPKMT Gene
External Ids for VCPKMT Gene
- HGNC: 20352
- Entrez Gene: 79609
- Ensembl: ENSG00000100483
- OMIM: 615260
- UniProtKB: Q9H867
Previous HGNC Symbols for VCPKMT Gene
- C14orf138
- METTL21D
Previous GeneCards Identifiers for VCPKMT Gene
- GC14M050577
Summaries for VCPKMT Gene
GeneCards Summary for VCPKMT Gene
VCPKMT (Valosin Containing Protein Lysine Methyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. Gene Ontology (GO) annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is METTL21A.
UniProtKB/Swiss-Prot for VCPKMT Gene
-
Protein-lysine N-methyltransferase that specifically trimethylates Lys-315 of VCP/p97; this modification may decrease VCP ATPase activity.
Additional gene information for VCPKMT Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCPKMT Gene
Genomics for VCPKMT Gene
GeneHancer (GH) Regulatory Elements for VCPKMT Gene
Promoters and enhancers for VCPKMT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VCPKMT on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for VCPKMT Gene
Genomic Locations for VCPKMT Gene
- chr14:50,108,632-50,116,600
- (GRCh38/hg38)
- Size:
- 7,969 bases
- Orientation:
- Minus strand
- chr14:50,575,350-50,583,318
- (GRCh37/hg19)
Genomic View for VCPKMT Gene
Genes around VCPKMT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q21.3 by Ensembl
- 14q21.3 by Entrez Gene
- 14q21.3 by HGNC
VCPKMT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCPKMT Gene
Proteins for VCPKMT Gene
-
Protein details for VCPKMT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H867-MT21D_HUMAN
- Recommended name:
- Protein-lysine methyltransferase METTL21D
- Protein Accession:
- Q9H867
- B7ZLA3
- B7ZLA4
- Q2M2X3
- Q86T12
Protein attributes for VCPKMT Gene
- Size:
- 229 amino acids
- Molecular mass:
- 25807 Da
- Quaternary structure:
-
- Interacts with ALKBH6. Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation.
- SequenceCaution:
-
- Sequence=CAD62329.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for VCPKMT Gene
Post-translational modifications for VCPKMT Gene
- Ubiquitination at isoforms=122
Other Protein References for VCPKMT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for VCPKMT
- Invitrogen Antibodies for VCPKMT
- Search GeneTex for Antibodies for VCPKMT
Protein Products
-
OriGene Purified Proteins for VCPKMT
- Search Origene for MassSpec and Protein Over-expression Lysates for VCPKMT
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- ProSpec Recombinant Proteins for VCPKMT
- Search GeneTex for Proteins for VCPKMT
Assay Products
No data available for DME Specific Peptides for VCPKMT Gene
Domains & Families for VCPKMT Gene
Gene Families for VCPKMT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for VCPKMT Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for VCPKMT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H867- Family:
-
- Belongs to the methyltransferase superfamily. METTL21 family.
Function for VCPKMT Gene
Molecular function for VCPKMT Gene
- UniProtKB/Swiss-Prot Function:
- Protein-lysine N-methyltransferase that specifically trimethylates Lys-315 of VCP/p97; this modification may decrease VCP ATPase activity.
Enzyme Numbers (IUBMB) for VCPKMT Gene
Phenotypes From GWAS Catalog for VCPKMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 22948820 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016279 | protein-lysine N-methyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0051117 | ATPase binding | IPI | 23349634 |
Phenotypes for VCPKMT Gene
- MGI mutant phenotypes for VCPKMT:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for VCPKMT:
Animal Models for VCPKMT Gene
- MGI Knock Outs for VCPKMT:
-
- Vcpkmt tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for VCPKMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCPKMT gene
- Search ViGene Biosciences for VCPKMT
CRISPR Products
-
OriGene CRISPR knockouts for VCPKMT
- genomics-online: gRNA clones - Search results for available METTL21D gene related products
- Applied Biological Materials CRISPR for VCPKMT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCPKMT
miRNA for VCPKMT Gene
- miRTarBase miRNAs that target VCPKMT
miRNA Products
- Search ViGene Biosciences for VCPKMT
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCPKMT
- Browse OriGene Inhibitory RNA Products For VCPKMT
- genomics-online: shRNA clones - Search results for available METTL21D gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCPKMT gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available METTL21D gene related products
- orf clones - Search results for available METTL21D gene related products
- Applied Biological Materials Clones for VCPKMT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VCPKMT
-
ViGene Biosciences adenoviral particle packaged cDNA for VCPKMT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VCPKMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCPKMT gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VCPKMT Gene
Localization for VCPKMT Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCPKMT Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 23349634 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0043234 | protein complex | IDA | 23349634 |
Pathways & Interactions for VCPKMT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Protein methylation | ||
Pathways by source for VCPKMT Gene
3 Reactome pathways for VCPKMT Gene
Interacting Proteins for VCPKMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006479 | protein methylation | TAS | -- |
| GO:0018022 | peptidyl-lysine methylation | IMP | 23349634 |
| GO:0018023 | peptidyl-lysine trimethylation | IDA | 22948820 |
| GO:0032259 | methylation | IEA | -- |
| GO:0032780 | negative regulation of ATPase activity | IMP | 23349634 |
Transcripts for VCPKMT Gene
mRNA/cDNA for VCPKMT Gene
- (6) REFSEQ mRNAs :
- (289) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for VCPKMT
- genomics-online: gRNA clones - Search results for available METTL21D gene related products
- Applied Biological Materials CRISPR for VCPKMT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCPKMT
miRNA Products
- Search ViGene Biosciences for VCPKMT
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCPKMT
- Browse OriGene Inhibitory RNA Products For VCPKMT
- genomics-online: shRNA clones - Search results for available METTL21D gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCPKMT gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available METTL21D gene related products
- orf clones - Search results for available METTL21D gene related products
- Applied Biological Materials Clones for VCPKMT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: |
Expression for VCPKMT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
This gene is overexpressed in Oral epithelium (44.3), Lymph node (15.3), and Fetal ovary (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VCPKMT Gene
NURSA nuclear receptor signaling pathways regulating expression of VCPKMT Gene:
VCPKMTEvidence on tissue expression from TISSUES for VCPKMT Gene
- Nervous system(4.3)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for VCPKMT
-
OriGene qPCR primer pairs and template standards for VCPKMT
- genomics-online: primer clones - Search results for available METTL21D gene related products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCPKMT Gene
Orthologs for VCPKMT Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | METTL21D 33 |
|
||
| VCPKMT 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | VCPKMT 34 |
|
OneToOne | |
| METTL21D 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | VCPKMT 34 |
|
OneToOne | |
| METTL21D 33 |
|
||||
| mouse (Mus musculus) |
Mammalia | Mettl21d 34 |
|
OneToOne | |
| Vcpkmt 33 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | LOC102548559 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | VCPKMT 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | VCPKMT 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | METTL21D 33 |
|
||
| VCPKMT 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | VCPKMT 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vcpkmt 33 |
|
||
| Str.15857 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | vcpkmt 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C42C1.13 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G73320 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0101100 33 |
|
- Species where no ortholog for VCPKMT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VCPKMT Gene
(1) SIMAP similar genes for VCPKMT Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for VCPKMT Gene
Variants for VCPKMT Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10658395 | benign, Noonan syndrome 9 | 50,118,857(-) | AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA/AAAAAAAAAAAA/AAAAAAAAAAAAA | upstream_transcript_variant | |
| rs138133010 | likely-benign, Noonan syndrome 9 | 50,118,599(-) | C/A/T | upstream_transcript_variant | |
| rs140995728 | likely-benign, Noonan syndrome 9 | 50,118,391(-) | G/A/C | upstream_transcript_variant | |
| rs143166880 | uncertain-significance, Noonan syndrome 9 | 50,118,840(-) | G/T | upstream_transcript_variant | |
| rs146802994 | likely-benign, Noonan syndrome 9 | 50,118,513(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.13;
84.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VCPKMT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VCPKMT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCPKMT Gene
Disorders for VCPKMT Gene
Additional Disease Information for VCPKMT
No disorders were found for VCPKMT Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VCPKMT Gene
Publications for VCPKMT Gene
- Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 2 3 4 58
- A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for VCPKMT Gene
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- OriGene qPCR primer pairs and template standards for VCPKMT
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- Invitrogen Antibodies for VCPKMT
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- ViGene Biosciences adenoviral particle packaged cDNA for VCPKMT gene
- ViGene Biosciences lentiviral particle packaged cDNA for VCPKMT gene
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- Search ViGene Biosciences for VCPKMT
- Horizon Cell Lines for VCPKMT
- genomics-online: cdna clones - Search results for available METTL21D gene related products
- orf clones - Search results for available METTL21D gene related products
- genomics-online: gRNA clones - Search results for available METTL21D gene related products
- genomics-online: primer clones - Search results for available METTL21D gene related products
- genomics-online: shRNA clones - Search results for available METTL21D gene related products
Sources for VCPKMT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew