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Aliases for VCPIP1 Gene

Aliases for VCPIP1 Gene

  • Valosin Containing Protein Interacting Protein 1 2 3 5
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 3 4
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 3 4
  • VCP/P47 Complex-Interacting 135-KDa Protein 3 4
  • VCIP135 3 4
  • Valosin Containing Protein (P97)/P47 Complex Interacting Protein 1 2
  • Deubiquitinating Protein VCIP135 3
  • EC 3.4.19.12 4
  • KIAA1850 4
  • DUBA3 3

External Ids for VCPIP1 Gene

Previous GeneCards Identifiers for VCPIP1 Gene

  • GC08M067706
  • GC08M067540
  • GC08M063032

Summaries for VCPIP1 Gene

GeneCards Summary for VCPIP1 Gene

VCPIP1 (Valosin Containing Protein Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for VCPIP1 Gene

  • Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Gene Wiki entry for VCPIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCPIP1 Gene

Genomics for VCPIP1 Gene

Regulatory Elements for VCPIP1 Gene

Enhancers for VCPIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G066531 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +132.8 132803 6.1 PKNOX1 ATF1 SIN3A RAD21 RFX5 GATA2 SCRT2 FOS IKZF2 CBFB RNU6-1324P MYBL1 ADHFE1 VCPIP1 MCMDC2 GC08M066613
GH08G066605 1.7 FANTOM5 Ensembl ENCODE 2.9 +56.8 56841 8.9 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A YY1 SLC30A9 ZNF143 SP3 ADHFE1 RRS1-AS1 RRS1 MYBL1 C8orf44 C8orf46 VCPIP1 GC08M066613 RNU6-1324P
GH08G066922 1.1 ENCODE 4.3 -257.4 -257389 5.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ARFGEF1 C8orf44 TCF24 VCPIP1 SNORD87 GC08M066924 SNHG6
GH08G066711 1.6 FANTOM5 ENCODE dbSUPER 1.6 -45.9 -45872 3.0 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 FOS MXD4 SGK3 C8orf44 VCPIP1 PTTG3P
GH08G066781 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -114.5 -114486 1.4 FOSL2 IKZF2 SPI1 SGK3 C8orf44 VCPIP1 GC08M066750 PTTG3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VCPIP1 on UCSC Golden Path with GeneCards custom track

Promoters for VCPIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225431 -83 2201 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1

Genomic Location for VCPIP1 Gene

Chromosome:
8
Start:
66,628,487 bp from pter
End:
66,667,217 bp from pter
Size:
38,731 bases
Orientation:
Minus strand

Genomic View for VCPIP1 Gene

Genes around VCPIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VCPIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VCPIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCPIP1 Gene

Proteins for VCPIP1 Gene

  • Protein details for VCPIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JH7-VCIP1_HUMAN
    Recommended name:
    Deubiquitinating protein VCIP135
    Protein Accession:
    Q96JH7
    Secondary Accessions:
    • Q504T4
    • Q86T93
    • Q86W01
    • Q8N3A9
    • Q9H5R8

    Protein attributes for VCPIP1 Gene

    Size:
    1222 amino acids
    Molecular mass:
    134321 Da
    Quaternary structure:
    • Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP.
    SequenceCaution:
    • Sequence=BAB15552.1; Type=Frameshift; Positions=1065, 1110; Evidence={ECO:0000305}; Sequence=BAB47479.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for VCPIP1 Gene

Post-translational modifications for VCPIP1 Gene

  • Ubiquitination at posLast=182182, isoforms=199, posLast=362362, isoforms=376, isoforms=691, Lys729, Lys764, Lys870, Lys879, isoforms=1015, and posLast=10281028
  • Modification sites at PhosphoSitePlus

Other Protein References for VCPIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VCPIP1 (VCIP135)
  • Santa Cruz Biotechnology (SCBT) Antibodies for VCPIP1

No data available for DME Specific Peptides for VCPIP1 Gene

Domains & Families for VCPIP1 Gene

Gene Families for VCPIP1 Gene

Protein Domains for VCPIP1 Gene

Suggested Antigen Peptide Sequences for VCPIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VCPIP1: view

No data available for UniProtKB/Swiss-Prot for VCPIP1 Gene

Function for VCPIP1 Gene

Molecular function for VCPIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for VCPIP1 Gene

Gene Ontology (GO) - Molecular Function for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity ISS --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with VCPIP1: view
genes like me logo Genes that share phenotypes with VCPIP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VCPIP1 Gene

Localization for VCPIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCPIP1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VCPIP1 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 3
plasma membrane 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
genes like me logo Genes that share ontologies with VCPIP1: view

Pathways & Interactions for VCPIP1 Gene

SuperPathways for VCPIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006508 proteolysis IEA --
GO:0007030 Golgi organization IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016320 endoplasmic reticulum membrane fusion IEA --
genes like me logo Genes that share ontologies with VCPIP1: view

No data available for Pathways by source and SIGNOR curated interactions for VCPIP1 Gene

Drugs & Compounds for VCPIP1 Gene

(1) Drugs for VCPIP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NMS-873 Pharma VCP/p97 inhibitor,selective and allosteric 0

(1) ApexBio Compounds for VCPIP1 Gene

Compound Action Cas Number
NMS-873 VCP/p97 inhibitor,selective and allosteric 1418013-75-8
genes like me logo Genes that share compounds with VCPIP1: view

Transcripts for VCPIP1 Gene

mRNA/cDNA for VCPIP1 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VCPIP1 Gene

Valosin containing protein (p97)/p47 complex interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCPIP1 Gene

No ASD Table

Relevant External Links for VCPIP1 Gene

GeneLoc Exon Structure for
VCPIP1
ECgene alternative splicing isoforms for
VCPIP1

Expression for VCPIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VCPIP1 Gene

Protein differential expression in normal tissues from HIPED for VCPIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.3), Brain (10.1), CD8 Tcells (7.9), and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VCPIP1 Gene



Protein tissue co-expression partners for VCPIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VCPIP1 Gene:

VCPIP1

SOURCE GeneReport for Unigene cluster for VCPIP1 Gene:

Hs.632066

Evidence on tissue expression from TISSUES for VCPIP1 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with VCPIP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCPIP1 Gene

Orthologs for VCPIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VCPIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCPIP1 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia VCPIP1 34 35
  • 95.12 (n)
rat
(Rattus norvegicus)
Mammalia Vcpip1 34
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia VCPIP1 34 35
  • 92.05 (n)
mouse
(Mus musculus)
Mammalia Vcpip1 34 16 35
  • 91.74 (n)
oppossum
(Monodelphis domestica)
Mammalia VCPIP1 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCPIP1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves VCPIP1 34 35
  • 79.6 (n)
lizard
(Anolis carolinensis)
Reptilia VCPIP1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vcpip1 34
  • 73.15 (n)
zebrafish
(Danio rerio)
Actinopterygii vcpip1 34 35
  • 66.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
Species where no ortholog for VCPIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VCPIP1 Gene

ENSEMBL:
Gene Tree for VCPIP1 (if available)
TreeFam:
Gene Tree for VCPIP1 (if available)

Paralogs for VCPIP1 Gene

No data available for Paralogs for VCPIP1 Gene

Variants for VCPIP1 Gene

Sequence variations from dbSNP and Humsavar for VCPIP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000182571 -- 66,663,182(+) TACTA(C/T)GTCTG intron-variant
rs1000310387 -- 66,652,574(+) TGCCA(C/T)TGCAC intron-variant
rs1000344141 -- 66,658,514(+) AGACA(A/G)AGTCT intron-variant
rs1000357975 -- 66,637,843(+) GGCAG(G/T)CACCT intron-variant
rs1000371243 -- 66,653,303(+) ACCTC(A/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VCPIP1 Gene

Variant ID Type Subtype PubMed ID
esv997781 CNV deletion 20482838
nsv831346 CNV loss 17160897

Variation tolerance for VCPIP1 Gene

Residual Variation Intolerance Score: 2.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VCPIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VCPIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCPIP1 Gene

Disorders for VCPIP1 Gene

Relevant External Links for VCPIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VCPIP1

No disorders were found for VCPIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VCPIP1 Gene

Publications for VCPIP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen T.E. … Komander D. (Cell 2013) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PMID: 12509440) Ficarro S. … Visconti P.E. (J. Biol. Chem. 2003) 2 3 64

Products for VCPIP1 Gene

Sources for VCPIP1 Gene

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