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Aliases for VCPIP1 Gene

Aliases for VCPIP1 Gene

  • Valosin Containing Protein (P97)/P47 Complex Interacting Protein 1 2 3
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 3 4
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 3 4
  • VCP/P47 Complex-Interacting 135-KDa Protein 3 4
  • KIAA1850 4 6
  • VCIP135 3 4
  • Valosin-Containing Protein (P97)/P47 Complex-Interacting Protein P135 3
  • Deubiquitinating Protein VCIP135 3
  • VCPIP1 VCIP135 6
  • EC 3.4.19.12 4
  • DUBA3 3

External Ids for VCPIP1 Gene

Summaries for VCPIP1 Gene

GeneCards Summary for VCPIP1 Gene

VCPIP1 (Valosin Containing Protein (P97)/P47 Complex Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for VCPIP1 Gene

  • Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Gene Wiki entry for VCPIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCPIP1 Gene

Genomics for VCPIP1 Gene

Genomic Location for VCPIP1 Gene

Start:
66,628,487 bp from pter
End:
66,667,217 bp from pter
Size:
38,731 bases
Orientation:
Minus strand

Genomic View for VCPIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCPIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCPIP1 Gene

Regulatory Elements for VCPIP1 Gene

Proteins for VCPIP1 Gene

  • Protein details for VCPIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JH7-VCIP1_HUMAN
    Recommended name:
    Deubiquitinating protein VCIP135
    Protein Accession:
    Q96JH7
    Secondary Accessions:
    • Q504T4
    • Q86T93
    • Q86W01
    • Q8N3A9
    • Q9H5R8

    Protein attributes for VCPIP1 Gene

    Size:
    1222 amino acids
    Molecular mass:
    134321 Da
    Quaternary structure:
    • Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP.
    SequenceCaution:
    • Sequence=BAB15552.1; Type=Frameshift; Positions=1065, 1110; Evidence={ECO:0000305}; Sequence=BAB47479.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for VCPIP1 Gene

Proteomics data for VCPIP1 Gene at MOPED

Post-translational modifications for VCPIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys182, Lys199, Lys362, Lys376, Lys691, Lys729, Lys764, Lys870, Lys879, Lys1015, and Lys1028

Other Protein References for VCPIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCPIP1 Gene

Domains for VCPIP1 Gene

Gene Families for VCPIP1 Gene

HGNC:
  • OTUD :OTU domain containing

Protein Domains for VCPIP1 Gene

UniProtKB/Swiss-Prot:

VCIP1_HUMAN
Domain:
  • Contains 1 OTU domain.:
    • Q96JH7
genes like me logo Genes that share domains with VCPIP1: view

Function for VCPIP1 Gene

Molecular function for VCPIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for VCPIP1 Gene

Gene Ontology (GO) - Molecular Function for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity ISS --
genes like me logo Genes that share ontologies with VCPIP1: view

miRNA for VCPIP1 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VCPIP1 Gene

Localization for VCPIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCPIP1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VCPIP1 Gene COMPARTMENTS Subcellular localization image for VCPIP1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus --
GO:0005795 Golgi stack IEA --
genes like me logo Genes that share ontologies with VCPIP1: view

Pathways for VCPIP1 Gene

SuperPathways for VCPIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007030 Golgi organization --
GO:0007067 mitotic nuclear division IEA --
GO:0016320 endoplasmic reticulum membrane fusion IEA --
GO:0016567 protein ubiquitination ISS --
genes like me logo Genes that share ontologies with VCPIP1: view

No data available for Pathways by source for VCPIP1 Gene

Transcripts for VCPIP1 Gene

mRNA/cDNA for VCPIP1 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VCPIP1 Gene

Valosin containing protein (p97)/p47 complex interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VCPIP1 Gene

No ASD Table

Relevant External Links for VCPIP1 Gene

GeneLoc Exon Structure for
VCPIP1
ECgene alternative splicing isoforms for
VCPIP1

Expression for VCPIP1 Gene

mRNA expression in normal human tissues for VCPIP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VCPIP1 Gene

SOURCE GeneReport for Unigene cluster for VCPIP1 Gene Hs.632066

genes like me logo Genes that share expressions with VCPIP1: view

Orthologs for VCPIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VCPIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCPIP1 36
  • 99.56 (n)
  • 99.58 (a)
VCPIP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VCPIP1 36
  • 92.05 (n)
  • 94.52 (a)
VCPIP1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VCPIP1 36
  • 95.12 (n)
  • 97.47 (a)
VCPIP1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vcpip1 36
  • 91.74 (n)
  • 95.51 (a)
Vcpip1 16
Vcpip1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VCPIP1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCPIP1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vcpip1 36
  • 92.19 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves VCPIP1 36
  • 79.6 (n)
  • 85.38 (a)
VCPIP1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCPIP1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vcpip1 36
  • 73.15 (n)
  • 79.12 (a)
zebrafish
(Danio rerio)
Actinopterygii vcpip1 36
  • 66.01 (n)
  • 73.55 (a)
vcpip1 37
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for VCPIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VCPIP1 Gene

ENSEMBL:
Gene Tree for VCPIP1 (if available)
TreeFam:
Gene Tree for VCPIP1 (if available)

Paralogs for VCPIP1 Gene

No data available for Paralogs for VCPIP1 Gene

Variants for VCPIP1 Gene

Sequence variations from dbSNP and Humsavar for VCPIP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2454665 -- 66,639,399(-) ccagc(C/T)taggc intron-variant
rs2454666 -- 66,637,093(-) cctca(G/T)cctcc intron-variant
rs2454669 -- 66,655,054(-) GAATC(C/T)TAAAG intron-variant
rs2467749 -- 66,639,386(-) CAGAG(C/T)TGAGA intron-variant
rs2936697 -- 66,662,985(-) tggga(A/C)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VCPIP1 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv997781 CNV Deletion 20482838

Relevant External Links for VCPIP1 Gene

HapMap Linkage Disequilibrium report
VCPIP1

Disorders for VCPIP1 Gene

No disorders were found for VCPIP1 Gene.

No data available for UniProtKB/Swiss-Prot for VCPIP1 Gene

Publications for VCPIP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4
  4. VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. (PMID: 12473691) Uchiyama K. … Kondo H. (J. Cell Biol. 2002) 3 23
  5. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PMID: 12509440) Ficarro S. … Visconti P.E. (J. Biol. Chem. 2003) 2 3

Products for VCPIP1 Gene

  • antibodies-online proteins for VCPIP1
  • antibodies-online antibodies for VCPIP1
  • antibodies-online kits for VCPIP1

Sources for VCPIP1 Gene

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