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Aliases & Descriptions for VCPIP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686G038 2 | | DUBA3 1, 2 | | EC 3.4.22.- 3 | | FLJ23132 1, 2 | | FLJ60694 2 | | KIAA1850 1, 2, 3, 5 | | VCIP135 1, 2, 3 |
| | | Descriptions |
|---|
| VCPIP1 VCIP135 5 | Valosin-containing protein p97/p47 complex-interacting protein 1 3 | Valosin-containing protein p97/p47 complex-interacting protein p135 3 | valosin containing protein (p97)/p47 complex interacting protein 1 2 | valosin-containing protein (p97)/p47 complex-interacting protein p135 2 |
|
| | Search outside databases for aliases for VCPIP1 gene |
Summaries for VCPIP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VCIP1_HUMAN, Q96JH7Function: Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity)Gene Wiki entry for VCPIP1 |
Genomic Location for VCPIP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VCPIP1 gene 
Entrez Gene cytogenetic band: 8q13 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13VCPIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M067706:
(about GC identifiers)
Start:
|
67,703,300 bp from pter |
End:
|
67,742,036 bp from pter |
Size:
|
38,737 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008183.18
| Proteins for VCPIP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VCIP1_HUMAN, Q96JH7 (See
protein sequence)Recommended Name: Deubiquitinating protein VCIP135 Size: 1222 amino acids; 134321 Da
Subunit: Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP (By similarity)
Subcellular location: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity)
Sequence caution: Sequence=BAB15552.1; Type=Frameshift; Positions=1065, 1110;
Secondary accessions: Q504T4 Q86T93 Q86W01 Q8N3A9 Q9H5R8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_079330.2
ENSEMBL proteins: ENSP00000309031
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VCPIP1: Assays for VCPIP1: | Protein
Domains/ Families for VCPIP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96JH7
ProtoNet protein and cluster: Q96JH7 1 Blocks protein family: IPB003323 OTU-like cysteine protease
UniProtKB/Swiss-Prot: VCIP1_HUMAN, Q96JH7Similarity: Contains 1 OTU domain | Gene Function for VCPIP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025054
Applied Biosystems Silencer® siRNAs for VCPIP1
Sigma-Aldrich siRNA for VCPIP1  Sigma-Aldrich shRNA for VCPIP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025054                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025054                                  untagged cDNA clone in CMV expression vector: NM_025054 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025054
UniProtKB/Swiss-Prot: VCIP1_HUMAN, Q96JH7Function: Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity)Enzyme Number (IUBMB): EC 3.4.22.- 3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004843 | ubiquitin-specific protease activity |
ISS | -- | | GO:0008233 | peptidase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- | About this table | Pathways & Interactions for VCPIP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/8 Interacting proteins for VCPIP1 (ENSP000003090313 Q96JH72) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
ISS | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for VCPIP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VCPIP1
|
Transcripts for VCPIP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025054
Sigma-Aldrich siRNA for VCPIP1  Sigma-Aldrich shRNA for VCPIP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_025054 REFSEQ mRNAs for VCPIP1 gene: NM_025054.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_025054               OriGene GFP tagged cDNA clone in CMV expression vector: NM_025054                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025054                                  untagged cDNA clone in CMV expression vector: NM_025054  Additional cDNA sequence: AB058753.1 AF088033.1 AK026785.1 AK225580.1 AK297345.1 AL832606.2 AL834476.1 BC012498.1 BC049379.1 BC062426.1 BC094799.1 BC118917.1 CR593204.1 CR936659.1 4 DOTS entries: DT.40308443 DT.100793230 DT.428776 DT.92352710 2 AceView cDNA sequences:BF910941 BF377808
highest scoring ESTs for VCPIP1:AA405241 AB058753 AK026785 AL708282 AL712343 AL832606 AL834476 BC012498 BC049379 BC062426 Unigene Cluster for VCPIP1: Valosin containing protein (p97)/p47 complex interacting protein 1 Hs.632066 [show with all ESTs]Unigene Representative Sequence: CR936659
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000310421
|
Expression for VCPIP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VCPIP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VCPIP1
1 / 2 / 3 8 probe-sets matching VCPIP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTTTTGTAGT
SOURCE GeneReport for Unigene cluster: Hs.632066
|
Orthologs for VCPIP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VCPIP1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for VCPIP1
ENSEMBL Gene Tree for VCPIP1 | Paralogs for VCPIP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for VCPIP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VCPIP1 (up to first 250kb)
|
Disorders & Mutations for VCPIP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611745
|
Medical News for VCPIP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VCPIP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for VCPIP1 gene (see all 19
):- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)2, 3, 4 Nagase T....Ohara O. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. (PubMed id 12509440)2, 3 Ficarro S....Visconti P.E. (2003)
- VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. (PubMed id 12473691)1, 3 Uchiyama K....Kondo H. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)4 Denis N.J.... Figeys D. (2007)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
|
Search for VCPIP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VCPIP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VCPIP1
(According to HUGE)
About This Section
| |
Specialized Databases showing VCPIP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VCPIP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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Incremental update: 13 Oct 2009
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