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Aliases for VCPIP1 Gene

Aliases for VCPIP1 Gene

  • Valosin Containing Protein Interacting Protein 1 2 3 5
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 3 4
  • Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 3 4
  • VCP/P47 Complex-Interacting 135-KDa Protein 3 4
  • VCIP135 3 4
  • Valosin Containing Protein (P97)/P47 Complex Interacting Protein 1 2
  • Deubiquitinating Protein VCIP135 3
  • EC 3.4.19.12 4
  • KIAA1850 4
  • DUBA3 3

External Ids for VCPIP1 Gene

Previous GeneCards Identifiers for VCPIP1 Gene

  • GC08M067706
  • GC08M067540
  • GC08M063032

Summaries for VCPIP1 Gene

GeneCards Summary for VCPIP1 Gene

VCPIP1 (Valosin Containing Protein Interacting Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for VCPIP1 Gene

  • Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Gene Wiki entry for VCPIP1 Gene

Additional gene information for VCPIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCPIP1 Gene

Genomics for VCPIP1 Gene

GeneHancer (GH) Regulatory Elements for VCPIP1 Gene

Promoters and enhancers for VCPIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I066663 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 1019 6.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 C8orf44 C8orf44-SGK3 VCPIP1 ARFGEF1 MYBL1 C8orf46 ENSG00000201365
GH08I066605 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 2.9 +56.8 56840 8.8 PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF213 ZNF143 SP3 MYBL1 ARFGEF1 C8orf44 ADHFE1 RRS1 RRS1-AS1 C8orf46 VCPIP1 GC08M066612 GC08M066613
GH08I066922 Promoter/Enhancer 1.6 Ensembl ENCODE 4.3 -257.4 -257388 5.1 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 SNHG6 ARFGEF1 C8orf44 CSPP1 TCF24 VCPIP1 GC08M066923 GC08M066924 SNORD87 MCMDC2
GH08I066531 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +132.8 132803 6.1 PKNOX1 ATF1 FOXA2 SIN3A BATF RAD21 RFX5 ZNF335 SCRT2 FOS RNU6-1324P MYBL1 ADHFE1 VCPIP1 MCMDC2 GC08M066613
GH08I066711 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 -45.9 -45871 3 CLOCK ATF1 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 SGK3 C8orf44 VCPIP1 C8orf44-SGK3 PTTG3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VCPIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VCPIP1 gene promoter:

Genomic Locations for VCPIP1 Gene

Genomic Locations for VCPIP1 Gene
chr8:66,628,487-66,667,217
(GRCh38/hg38)
Size:
38,731 bases
Orientation:
Minus strand
chr8:67,540,722-67,579,452
(GRCh37/hg19)

Genomic View for VCPIP1 Gene

Genes around VCPIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VCPIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VCPIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCPIP1 Gene

Proteins for VCPIP1 Gene

  • Protein details for VCPIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JH7-VCIP1_HUMAN
    Recommended name:
    Deubiquitinating protein VCIP135
    Protein Accession:
    Q96JH7
    Secondary Accessions:
    • Q504T4
    • Q86T93
    • Q86W01
    • Q8N3A9
    • Q9H5R8

    Protein attributes for VCPIP1 Gene

    Size:
    1222 amino acids
    Molecular mass:
    134321 Da
    Quaternary structure:
    • Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP.
    SequenceCaution:
    • Sequence=BAB15552.1; Type=Frameshift; Positions=1065, 1110; Evidence={ECO:0000305}; Sequence=BAB47479.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for VCPIP1 Gene

Post-translational modifications for VCPIP1 Gene

  • Ubiquitination at posLast=182182, posLast=199199, posLast=362362, posLast=376376, posLast=691691, posLast=729729, isoforms=764, posLast=870870, posLast=879879, isoforms=1015, and isoforms=1028

Other Protein References for VCPIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCPIP1 Gene

Domains & Families for VCPIP1 Gene

Gene Families for VCPIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for VCPIP1 Gene

Suggested Antigen Peptide Sequences for VCPIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VCPIP1: view

No data available for UniProtKB/Swiss-Prot for VCPIP1 Gene

Function for VCPIP1 Gene

Molecular function for VCPIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes Lys-11- and Lys-48-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for VCPIP1 Gene

Gene Ontology (GO) - Molecular Function for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity ISS,IEA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with VCPIP1: view
genes like me logo Genes that share phenotypes with VCPIP1: view

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VCPIP1 Gene

Localization for VCPIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCPIP1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VCPIP1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
genes like me logo Genes that share ontologies with VCPIP1: view

Pathways & Interactions for VCPIP1 Gene

SuperPathways for VCPIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VCPIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006508 proteolysis IEA --
GO:0007030 Golgi organization IEA --
GO:0016320 endoplasmic reticulum membrane fusion IEA --
GO:0016567 protein ubiquitination IEA,ISS --
genes like me logo Genes that share ontologies with VCPIP1: view

No data available for Pathways by source and SIGNOR curated interactions for VCPIP1 Gene

Drugs & Compounds for VCPIP1 Gene

(1) Drugs for VCPIP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NMS-873 Pharma VCP/p97 inhibitor,selective and allosteric 0

(1) ApexBio Compounds for VCPIP1 Gene

Compound Action Cas Number
NMS-873 VCP/p97 inhibitor,selective and allosteric 1418013-75-8
genes like me logo Genes that share compounds with VCPIP1: view

Drug Products

Transcripts for VCPIP1 Gene

mRNA/cDNA for VCPIP1 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VCPIP1 Gene

Valosin containing protein (p97)/p47 complex interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VCPIP1 Gene

No ASD Table

Relevant External Links for VCPIP1 Gene

GeneLoc Exon Structure for
VCPIP1
ECgene alternative splicing isoforms for
VCPIP1

Expression for VCPIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VCPIP1 Gene

Protein differential expression in normal tissues from HIPED for VCPIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.3), Brain (10.1), CD8 Tcells (7.9), and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VCPIP1 Gene



Protein tissue co-expression partners for VCPIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VCPIP1 Gene:

VCPIP1

SOURCE GeneReport for Unigene cluster for VCPIP1 Gene:

Hs.632066

Evidence on tissue expression from TISSUES for VCPIP1 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with VCPIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCPIP1 Gene

Orthologs for VCPIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VCPIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCPIP1 34 33
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VCPIP1 34 33
  • 95.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vcpip1 33
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia VCPIP1 34 33
  • 92.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vcpip1 34 16 33
  • 91.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VCPIP1 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCPIP1 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves VCPIP1 34 33
  • 79.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCPIP1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vcpip1 33
  • 73.15 (n)
zebrafish
(Danio rerio)
Actinopterygii vcpip1 34 33
  • 66.01 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for VCPIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VCPIP1 Gene

ENSEMBL:
Gene Tree for VCPIP1 (if available)
TreeFam:
Gene Tree for VCPIP1 (if available)

Paralogs for VCPIP1 Gene

No data available for Paralogs for VCPIP1 Gene

Variants for VCPIP1 Gene

Sequence variations from dbSNP and Humsavar for VCPIP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000182571 -- 66,663,182(-) T/C intron_variant
rs1000310387 -- 66,652,574(-) T/C intron_variant
rs1000344141 -- 66,658,514(-) G/A intron_variant
rs1000357975 -- 66,637,843(-) G/T intron_variant
rs1000371243 -- 66,653,303(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VCPIP1 Gene

Variant ID Type Subtype PubMed ID
esv997781 CNV deletion 20482838
nsv831346 CNV loss 17160897

Variation tolerance for VCPIP1 Gene

Residual Variation Intolerance Score: 2.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VCPIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VCPIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCPIP1 Gene

Disorders for VCPIP1 Gene

Additional Disease Information for VCPIP1

No disorders were found for VCPIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VCPIP1 Gene

Publications for VCPIP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. (PMID: 12509440) Ficarro S … Visconti PE (The Journal of biological chemistry 2003) 2 3 58

Products for VCPIP1 Gene

Sources for VCPIP1 Gene

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