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Aliases for VCP Gene

Aliases for VCP Gene

  • Valosin Containing Protein 2 3
  • Valosin-Containing Protein 2 3 4
  • 15S Mg(2+)-ATPase P97 Subunit 3 4
  • TER ATPase 3 4
  • IBMPFD1 3 6
  • ALS14 3 6
  • Transitional Endoplasmic Reticulum ATPase 3
  • Epididymis Secretory Protein Li 70 3
  • Epididymis Luminal Protein 220 3
  • Yeast Cdc48p Homolog 3
  • EC 3.6.4.6 4
  • HEL-S-70 3
  • HEL-220 3
  • IBMPFD 3
  • TERA 3
  • P97 3

External Ids for VCP Gene

Previous GeneCards Identifiers for VCP Gene

  • GC09M035368
  • GC09M035225
  • GC09M035046
  • GC09M035011

Summaries for VCP Gene

Entrez Gene Summary for VCP Gene

  • The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for VCP Gene

VCP (Valosin Containing Protein) is a Protein Coding gene. Diseases associated with VCP include inclusion body myopathy with early-onset paget disease and frontotemporal dementia 1 and amyotrophic lateral sclerosis 14, with or without frontotemporal dementia. Among its related pathways are Cytoskeletal Signaling and Cell Cycle / Checkpoint Control. GO annotations related to this gene include protein domain specific binding and lipid binding.

UniProtKB/Swiss-Prot for VCP Gene

  • Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation.

Gene Wiki entry for VCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCP Gene

Genomics for VCP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VCP Gene

Start:
35,056,064 bp from pter
End:
35,073,249 bp from pter
Size:
17,186 bases
Orientation:
Minus strand

Genomic View for VCP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCP Gene

Proteins for VCP Gene

  • Protein details for VCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55072-TERA_HUMAN
    Recommended name:
    Transitional endoplasmic reticulum ATPase
    Protein Accession:
    P55072
    Secondary Accessions:
    • B2R5T8
    • Q0V924
    • Q2TAI5
    • Q969G7
    • Q9UCD5

    Protein attributes for VCP Gene

    Size:
    806 amino acids
    Molecular mass:
    89322 Da
    Quaternary structure:
    • Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1L, binding to this heterodimer inhibits Golgi-membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternary complex containing NPLOC4, UFD1L and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum biogenesis. Interacts with VIMP/SELS and SYVN1, as well as with DERL1, DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP. Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXD2 and RNF19A. Interacts with CASR. Interacts with UBXN6, UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 and TRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts with RHBDD1 (via C-terminal domain). Interacts with SPRTN; leading to recruitment to stalled replication forks. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP. Interacts with KIAA0196. Interacts with UBOX5. Interacts (via N-terminus) with UBXN7, UBXN8, and probably several other UBX domain-containing proteins (via UBX domains); the interactions are mutually exclusive with VIM-dependent interactions such as those with AMFR and VIMP.

    Three dimensional structures from OCA and Proteopedia for VCP Gene

neXtProt entry for VCP Gene

Proteomics data for VCP Gene at MOPED

Post-translational modifications for VCP Gene

  • ISGylated.
  • Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.
  • Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation.
  • Ubiquitination at Lys8, Lys18, Lys60, Lys81, Lys109, Lys148, Lys211, Lys217, Lys231, Lys251, Lys288, Lys295, Lys312, Lys336, Lys386, Lys486, Lys502, Lys505, Lys512, Lys524, Lys529, Lys584, Lys651, Lys658, Lys668, Lys696, and Lys754
  • Modification sites at PhosphoSitePlus

Other Protein References for VCP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VCP (VCP)

No data available for DME Specific Peptides for VCP Gene

Domains for VCP Gene

Gene Families for VCP Gene

HGNC:
  • AATP :ATPases / AAA-type

Graphical View of Domain Structure for InterPro Entry

P55072

UniProtKB/Swiss-Prot:

TERA_HUMAN :
  • P55072
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with VCP: view

Function for VCP Gene

Molecular function for VCP Gene

GENATLAS Biochemistry: valosin-containing protein,bound with high affinity to clathrin
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation.

Enzyme Numbers (IUBMB) for VCP Gene

Gene Ontology (GO) - Molecular Function for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 10364224
GO:0005524 ATP binding IEA --
GO:0008289 lipid binding IEA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with VCP: view
genes like me logo Genes that share phenotypes with VCP: view

Animal Models for VCP Gene

MGI Knock Outs for VCP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for VCP Gene

Localization for VCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCP Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VCP Gene COMPARTMENTS Subcellular localization image for VCP gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
cytoskeleton 2
vacuole 2
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 9452483
GO:0000836 Hrd1p ubiquitin ligase complex IDA 17872946
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with VCP: view

Pathways for VCP Gene

genes like me logo Genes that share pathways with VCP: view

Pathways by source for VCP Gene

4 Cell Signaling Technology pathways for VCP Gene
1 BioSystems pathway for VCP Gene
2 Reactome pathways for VCP Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair IDA 10855792
GO:0006310 DNA recombination --
GO:0006511 ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with VCP: view

Compounds for VCP Gene

(2) Drugbank Compounds for VCP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester
target

(14) Novoseek inferred chemical compound relationships for VCP Gene

Compound -log(P) Hits PubMed IDs
ptdins(3)p 45.2 1
atp 40.1 19
glutamine 38.3 9
n-ethylmaleimide 33.1 3
adp 32.4 5
genes like me logo Genes that share compounds with VCP: view

Transcripts for VCP Gene

Unigene Clusters for VCP Gene

Valosin containing protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5: - - - - -
SP6: - - -
SP7:

ExUns: 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for VCP Gene

GeneLoc Exon Structure for
VCP
ECgene alternative splicing isoforms for
VCP

Expression for VCP Gene

mRNA expression in normal human tissues for VCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VCP Gene

SOURCE GeneReport for Unigene cluster for VCP Gene Hs.529782

genes like me logo Genes that share expressions with VCP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VCP Gene

Orthologs for VCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCP 35
  • 99.34 (n)
  • 100 (a)
VCP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VCP 35
  • 92.89 (n)
  • 99.75 (a)
VCP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VCP 35
  • 93.59 (n)
  • 99.88 (a)
VCP 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vcp 35
  • 91.52 (n)
  • 100 (a)
Vcp 16
Vcp 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VCP 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCP 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vcp 35
  • 91.81 (n)
  • 99.88 (a)
chicken
(Gallus gallus)
Aves VCP 35
  • 83.91 (n)
  • 99.01 (a)
VCP 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCP 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vcp-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1287 35
vcp 35
  • 80.99 (n)
  • 97.64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9204 35
zebrafish
(Danio rerio)
Actinopterygii vcp 35
  • 80.81 (n)
  • 96.77 (a)
vcp 36
  • 97 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005630 35
  • 70.33 (n)
  • 84.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta TER94 35
  • 73.35 (n)
  • 85.38 (a)
TER94 36
  • 80 (a)
OneToOne
CG12010 37
  • 31 (a)
BG:DS06874.3 37
  • 33 (a)
TER94 37
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-48.1 36
  • 77 (a)
OneToMany
cdc-48.2 35
  • 68.31 (n)
  • 80.88 (a)
cdc-48.2 36
  • 78 (a)
OneToMany
C06A1.1 37
  • 75 (a)
prx-1 37
  • 29 (a)
K04D7.2b 37
  • 38 (a)
K04D7.2a 37
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR158W 35
  • 63.87 (n)
  • 72.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC48 35
  • 63.99 (n)
  • 71.63 (a)
CDC48 36
  • 67 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05676g 35
  • 62.69 (n)
  • 68.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7531 35
soybean
(Glycine max)
eudicotyledons Gma.4013 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03340 35
  • 69.96 (n)
  • 80.13 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.848 35
corn
(Zea mays)
Liliopsida Zm.1177 35
rice
(Oryza sativa)
Liliopsida Os.4689 35
Os03g0151800 35
  • 71.16 (n)
  • 80.42 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28850 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00018 35
  • 67.33 (n)
  • 73.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc48 35
  • 64.21 (n)
  • 71.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7152 36
  • 82 (a)
OneToOne
Species with no ortholog for VCP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VCP Gene

ENSEMBL:
Gene Tree for VCP (if available)
TreeFam:
Gene Tree for VCP (if available)

Paralogs for VCP Gene

genes like me logo Genes that share paralogs with VCP: view

No data available for Paralogs for VCP Gene

Variants for VCP Gene

Sequence variations from dbSNP and Humsavar for VCP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs489922 -- 35,069,611(+) CCACA(A/C)CTGGC intron-variant
rs495417 -- 35,070,207(+) TTCCA(A/C)AAGTC intron-variant
rs514492 -- 35,062,975(+) TATCT(C/T)ACCAT intron-variant
rs562381 -- 35,060,749(+) CCCAG(A/G)TCAAT intron-variant
rs595429 -- 35,055,672(+) tcgtg(C/T)agtgg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VCP Gene

Variant ID Type Subtype PubMed ID
nsv893043 CNV Gain 21882294

Relevant External Links for VCP Gene

HapMap Linkage Disequilibrium report
VCP
Human Gene Mutation Database (HGMD)
VCP
Locus Specific Mutation Databases (LSDB)
VCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCP Gene

Disorders for VCP Gene

(2) OMIM Diseases for VCP Gene (601023)

UniProtKB/Swiss-Prot

TERA_HUMAN
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:15034582, ECO:0000269 PubMed:15732117, ECO:0000269 PubMed:16247064}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia (ALS14) [MIM:613954]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS14 may develop frontotemporal dementia. {ECO:0000269 PubMed:21145000}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(30) Novoseek inferred disease relationships for VCP Gene

Disease -log(P) Hits PubMed IDs
inclusion body myopathy 95.9 38
frontotemporal dementia 89.3 49
myopathy 66.6 14
machado-joseph disease 65.4 2
limb girdle 59.9 1

Relevant External Links for VCP

GeneTests
VCP
GeneReviews
VCP
Genetic Association Database (GAD)
VCP
Human Genome Epidemiology (HuGE) Navigator
VCP
genes like me logo Genes that share disorders with VCP: view

Publications for VCP Gene

  1. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. (PMID: 7553851) Rabouille C. … Warren G. (Cell 1995) 2 3 23
  2. Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein. (PMID: 8413590) Pleasure I.T. … Keen J.H. (Nature 1993) 3 4 23
  3. Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PMID: 8595912) Druck T. … Keen J.H. (Genomics 1995) 2 3 23
  4. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. (PMID: 15034582) Watts G.D.J. … Kimonis V.E. (Nat. Genet. 2004) 3 4 23
  5. A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. (PMID: 15362974) McNeill H. … Cohen P. (Biochem. J. 2004) 3 4 23

Products for VCP Gene

  • Addgene plasmids for VCP

Sources for VCP Gene

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