VCP Gene
protein-coding GIFtS: 67
GCID: GC09M035056
|
|
valosin containing protein(Previous name: valosin-containing protein )
| |
Aliases
for VCP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Valosin Containing Protein1 2 | | ALS142 | | Valosin-Containing Protein1 2 3 | | TERA2 | | IBMPFD1 2 5 | | Transitional Endoplasmic Reticulum ATPase2 | | P971 | | Yeast Cdc48p Homolog2 | | 15S Mg(2+)-ATPase P97 Subunit2 3 | | EC 3.6.4.63 | | TER ATPase2 3 | | |
Export aliases for VCP gene to outside databasesPrevious GC identifers: GC09M035368 GC09M035225 GC09M035046 GC09M035011 |
Summaries
for VCP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VCP:
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved invesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structuralprotein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in anumber of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole bodyfunction, and ubiquitin-dependent protein degradation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from theendoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependentprocess. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for theexport of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. TheNPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of aclosed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of theVCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmicreticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strandbreaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damagesites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH)to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage
Gene Wiki entry for VCP (Valosin-containing protein)
|
Genomic Views
for VCP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VCP gene promoter:
GR Pax-5 RREB-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 CREB deltaCREB STAT3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VCP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VCP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13VCP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M035056: view genomic region
(about GC identifiers)
Start:
|
35,056,061 bp from pter |
End:
|
35,073,246 bp from pter |
Size:
|
17,186 bases |
Orientation:
|
minus strand |
|
Proteins
for VCP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072 (See
protein sequence)Recommended Name: Transitional endoplasmic reticulum ATPase Size: 806 amino acids; 89322 Da
Subunit: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of aternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCPhomohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgimembrane fusion. Binds to a heterodimer of NPLOC4 and UFD1L, binding to this heterodimer inhibits Golgi-membranefusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternarycomplex containing NPLOC4, UFD1L and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusionactivity and is required for Golgi and endoplasmic reticulum biogenesis (By similarity). Interacts with VIMP/SELS andSYVN1, as well as with DERL1, DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP.Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylationcomposed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXD2 and RNF19A. Interacts with CASR.Interacts with UBXN6, UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 andTRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmicreticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts withRHBDD1 (via C-terminus domain). Interacts with METTL21D. Interacts with SPRTN; leading to recruitment to stalledreplication forks
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyalineinclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewybodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of theendoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites ofdamage. Recruited to stalled replication forks via interaction with SPRTN
Caution: It is unclear how it participates to the recruitment of TP53BP1 at DNA damage sites. According to a firstreport, participates in the recruitment of TP53BP1 by promoting ubiquitination and removal of L3MBTL1 from DNA damagesites (PubMed:22120668). According to a second report, it acts by removing 'Lys-48'-linked ubiquitination from sitesof DNA damage (PubMed:22020440)
6/9 PDB 3D structures from  and Proteopedia  for VCP (see all 9):3EBB (3D)
3HU1 (3D)
3HU2 (3D)
3HU3 (3D)
3QC8 (3D)
3QQ7 (3D)
Secondary accessions: B2R5T8 Q0V924 Q2TAI5 Q969G7 Q9UCD5Explore the universe of human proteins at neXtProt for VCP: NX_P55072
Post-translational modifications:
Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation (By similarity)1
ISGylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55072
VCP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009057.1
ENSEMBL proteins: ENSP00000351777 ENSP00000392088 ENSP00000399456
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
VCP for ontologies About GeneDecksing
VCP Antibody Products:
Assay Products for VCP: |
Protein
Domains /
Families
for VCP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VCP for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P55072ProtoNet protein and cluster: P55072 2 Blocks protein families: IPB003338 AAA ATPase VAT IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Similarity: Belongs to the AAA ATPase family |
Function
for VCP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from theendoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependentprocess. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for theexport of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. TheNPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of aclosed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of theVCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmicreticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strandbreaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damagesites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH)to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damageCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for VCP:valosin-containing protein,bound with high affinity to clathrin
Enzyme Number (IUBMB): EC 3.6.4.61
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VCP (NM_007126) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VCP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCP |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
VCP for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for VCP:
Animal Models:
Mouse knock-out Vcptm1.1Dts for VCP
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Vcp):
VCP for phenotypes About GeneDecksing
|
Pathways & Interactions
for VCP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of degradation of wt-CFTR | | | 2 | Protein Stability | | | 3 | DNA Damage | | | 4 | Cytoskeletal Signaling | | | 5 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Cell Signaling Technology (CST) Pathways for VCP
2  GeneGo (Thomson Reuters) Pathways for VCP
1  BioSystems Pathway for VCP
1 
Kegg Pathway (Kegg details for VCP):
VCP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VCP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/291 Interacting proteins for VCP (P550721, 2, 3 ENSP000003517774) via UniProtKB, MINT, STRING, and/or I2D (see all 291)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
VCP for ontologies About GeneDecksing
|
Drugs & Compounds
for VCP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
VCP for compounds About GeneDecksing
 Browse Tocris compounds for VCP
2 DrugBank Compounds for VCP About this table
10/14 Novoseek chemical compound relationships for VCP gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ptdins(3)p |
45.2 |
1 |
12650639 (1) |
| atp |
40.1 |
29 |
12504076 (2), 12473691 (2), 12807884 (2), 12747802 (2) (see all 15) |
| glutamine |
38.3 |
10 |
18208395 (2), 17584300 (2), 11859409 (1), 17935506 (1) (see all 7) |
| n-ethylmaleimide |
33.1 |
7 |
7553850 (1), 10402460 (1), 14630332 (1) |
| adp |
32.4 |
6 |
12807884 (2), 12504076 (1), 10715114 (1), 18174159 (1) |
| bortezomib |
26.2 |
6 |
16966435 (4) |
| thapsigargin |
24.8 |
4 |
9405427 (1), 15306153 (1), 19302589 (1), 8672553 (1) |
| calcium |
8.85 |
8 |
9405427 (1), 8648106 (1), 15306153 (1), 8672553 (1) |
| tyrosine |
0.209 |
16 |
11087817 (4), 12509440 (2), 11086075 (1), 17166906 (1) (see all 7) |
| lipid |
0 |
1 |
10205162 (1) |
Search CenterWatch for drugs/clinical trials and news about VCP / TERA
|
Transcripts
for VCP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VCP gene: NM_007126.3 Unigene Cluster for VCP: Valosin containing protein Hs.529782 [show with all ESTs]Unigene Representative Sequence: BC0171717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358901(uc003zvy.2 uc010mkh.1) ENST00000493886(uc010mki.1)
ENST00000466100 ENST00000479300 ENST00000480327 ENST00000448530 ENST00000417448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VCP (NM_007126) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VCP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCP |
Additional cDNA sequence: AF100752.1 AF313486.1 AK307735.1 AK312310.1 AL137377.1 BC007562.1 BC012195.1 BC017171.1 BC096751.1 BC110913.1 BC121794.1 BC122550.1 Z70768.1 24/58 DOTS entries (see all 58): DT.92461598 DT.100878430 DT.100061017 DT.100878429 DT.121145904 DT.100878422 DT.92475957 DT.92017855 DT.91827473 DT.100878435 DT.100878436 DT.121146017 DT.100840391 DT.92461619 DT.100878441 DT.121145929 DT.121145989 DT.100716087 DT.99980507 DT.100039142 DT.121145950 DT.92461603 DT.121146013 DT.95186348 24/1276 AceView cDNA sequences (see all 1276): CK725077 AA552013 BQ224180 AL555738 BM551508 BE645970 BQ055785 BQ053517 CD358905 BQ215115 BC007562 BG820468 BQ961308 BE042757 AL552507 BG287026 BU740869 BQ063136 BQ883675 BM853854 BM905118 BM803789 BQ060980 AI888638
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VCP (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for VCP
|
Expression
for VCP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VCP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAAAAGG
About this image
See VCP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VCP
SOURCE GeneReport for Unigene cluster: Hs.529782
SABiosciences Expression via Pathway-Focused PCR Arrays including VCP:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VCP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VCP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VCP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VCP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCP |
Orthologs
for VCP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VCP gene from 9/43 species (see all 43) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VCP1 |
valosin containing protein |
83.91(n)
99.01(a) |
|
427410 NM_001044664.1 NP_001038129.1 |
lizard
(Anolis carolinensis) |
Reptilia |
VCP6 |
-- |
98(a) |
1 ↔ 1 |
GL343804.1(49927-72973) |
African clawed frog
(Xenopus laevis) |
Amphibia |
vcp-prov2 |
valosin containing protein |
77.91(n) |
|
X54240.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
vcp2 |
valosin containing protein |
77.45(n) |
|
327197 BC050488.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
TER941 , 3 |
ER fusion adenosinetriphosphatase3
CG2331-PA1 |
82(a)
(best of 3)3
72.29(n)1
83.63(a)1 |
|
46D13
360401 NM_001103779.11 NP_001097249.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
C06A1.13
cdc-48.21 |
transitional endoplasmic reticulum ATPase
homolog more3
Protein CDC-48.21 |
75(a)
(best of 4)3
67.93(n)1
80.08(a)1 |
|
II(10560241-10563298)3
1743091 NM_063304.41 NP_495705.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CDC481 |
Cdc48p |
63.42(n)
70.5(a) |
|
851431 NP_010157.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G033401 |
cell division control protein 48-e |
69.13(n)
78.32(a) |
|
831870 NM_120412.2 NP_568114.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.46892 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
76.3(n) |
|
AK098980.1 |
ENSEMBL Gene Tree for VCP (if available)
TreeFam Gene Tree for VCP (if available) |
Paralogs
for VCP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VCP gene
- SPATA5L12 SPATA52
18/20 SIMAP similar genes for VCP using alignment to 7 protein entries: TERA_HUMAN (see all proteins)
(see all similar genes):DKFZp434K0126 AFG3L2 SPATA5 DKFZp666D103 ATAD2B DKFZp434E0418
FTSH PSMC2 PSMC4 KATNAL2 PSMC1 PSMC6
PSMC5 NVL SPATA5L1 PEX1 PSMC3 DKFZp667C165
VCP for paralogs About GeneDecksing
|
Genomic Variants
for VCP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VCP (35056061 - 35073246 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VCP: --
Human Gene Mutation Database (HGMD): VCP
Locus Specific Mutation Databases (LSDB): VCP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VCP |
|
Disorders
/ Diseases
for VCP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VCP for disorders About GeneDecksing
OMIM gene information: 601023
OMIM disorders: 167320
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072
Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporaldementia (IBMPFD) [MIM:167320]; also known as muscular dystrophy, limb-girdle, with Paget disease of bone or pagetoidamyotrophic lateral sclerosis or pagetoid neuroskeletal syndrome or lower motor neuron degeneration with Paget-likebone disease. IBMPFD features adult-onset proximal and distal muscle weakness (clinically resembling limb girdlemuscular dystrophy), early-onset Paget disease of bone in most cases and premature frontotemporal dementia Defects in VCP are the cause of amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia(ALS14) [MIM:613954]. ALS14 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motorneurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Thepathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presenceof ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiologyof amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. Thedisease is inherited in 5-10% of the cases. Patients with ALS14 may develop frontotemporal dementia
20/68  diseases for VCP (see all 68): About MalaCardsinclusion body myopathy with early-onset paget disease and frontotemporal dementia inclusion body myopathy inclusion body myopathy with paget disease of bone and/or frontotemporal dementia machado-joseph disease
limb-girdle muscular dystrophy frontotemporal dementia inclusion body myositis non-small cell lung carcinoma
amyotrophic lateral sclerosis paget's disease of bone mammary paget's disease lateral sclerosis
motor neuron disease primary biliary cirrhosis muscular dystrophy werner syndrome
glucocorticoid resistance myopathy dementia monkeypox
7 diseases from the University of Copenhagen DISEASES database for VCP:Frontotemporal dementia Paget's disease of bone Mammary Paget's disease Myopathy
Amyotrophic lateral sclerosis Machado-Joseph disease Smallpox 10/30 Novoseek disease relationships for VCP gene (see all 30) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inclusion body myopathy |
95.9 |
56 |
17935506 (2), 19380227 (2), 17457594 (2), 17889967 (2) (see all 31) |
| frontotemporal dementia |
89.3 |
76 |
17279000 (3), 17457594 (3), 17618707 (3), 15732117 (3) (see all 34) |
| myopathy |
66.6 |
25 |
17763460 (3), 19208399 (2), 16822868 (1), 16199218 (1) (see all 11) |
| machado-joseph disease |
65.4 |
5 |
12351637 (1), 20414249 (1) |
| limb girdle |
59.9 |
1 |
20116073 (1) |
| neurodegenerative diseases |
55.2 |
7 |
18208395 (2), 12759168 (1), 16317258 (1), 18798739 (1) (see all 6) |
| motor neuron disease |
54.8 |
2 |
12759168 (1) |
| dementia |
51.1 |
20 |
19380227 (2), 12759168 (1), 16932700 (1), 16199218 (1) (see all 13) |
| neurodegeneration |
47.2 |
5 |
11859409 (3), 19237541 (1) |
| amyotrophic lateral sclerosis |
46.7 |
2 |
20496755 (1) |
GeneTests: VCP
Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia
Human Genome Epidemiology (HuGE) Navigator: VCP (6 documents)
Export disorders for VCP gene to outside databases
|
Publications
for VCP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VCP gene, integrated from 9 sources (see all 389):
(articles sorted by number of sources associating them with VCP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubxd1 is a novel co-factor of the human p97 ATPase. (PubMed id 18656546)1, 2, 9 Madsen L....Hartmann-Petersen R. (2008)
- Physical and functional interaction between dorfin and valosin- containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. (PubMed id 15456787)1, 2, 9 Ishigaki S.... Sobue G. (2004)
- A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. (PubMed id 15362974)1, 2, 9 McNeill H.... Cohen P. (2004)
- Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein. (PubMed id 8413590)1, 2, 9 Pleasure I.T.... Keen J.H. (1993)
- Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene. (PubMed id 16247064)1, 2, 9 Haubenberger D.... Zimprich A. (2005)
- Mutant valosin-containing protein causes a novel type of frontotemporal dementia. (PubMed id 15732117)1, 2, 9 Schroeder R.... Thal D.R. (2005)
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)1, 3, 9 Druck T....Keen J.H. (1995)
- Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. (PubMed id 15034582)1, 2, 9 Watts G.D.J.... Kimonis V.E. (2004)
- An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. (PubMed id 7553851)1, 3, 9 Rabouille C....Warren G. (1995)
- Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway. (PubMed id 18675248)1, 2, 9 Maruyama Y....Yamada M. (2008)
|
External Searches for VCP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VCP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VCP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VCP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VCP | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for VCP | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/VCP |
|
| | |
About This Section
| Patent Information for VCP gene:
Search GeneIP for patents involving VCP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VCP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for VCP | | OriGene shRNA RFP for VCP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VCP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VCP | | | OriGene Protein Over-expression Lysate for VCP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VCP | | OriGene 3'-UTR Clone for VCP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VCP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VCP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VCP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VCP | | OriGene Custom Protein Services for VCP | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VCP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VCP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VCP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VCP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VCP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VCP |
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