 |
 | Services
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Aliases &
Descriptions
for VCP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| IBMPFD 1, 2, 5 | | MGC131997 2 | | MGC148092 2 | | MGC8560 2 | | TERA 2 | | p97 1, 2 |
| | | Descriptions |
|---|
| 15S Mg(2+)-ATPase p97 subunit 3 | | TER ATPase 3 | | transitional endoplasmic reticulum ATPase 2 | | valosin-containing protein 2, 3 | | yeast Cdc48p homolog 2 |
|
| |
Search outside databases for aliases for VCP genePrevious GC identifers: GC09M035368 GC09M035225 |
Summaries
for VCP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VCP:
The protein encoded by this gene is a member of a family that includes putative ATP-binding
proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of
peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock
protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are
regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and
ubiquitin-dependent protein degradation. [provided by RefSeq]
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly
after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The
transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm
transition vesicles which derive from part-rough, part-smooth transitional elements of the
endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary
complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the
proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and
is necessary for the formation of a closed nuclear envelope (By similarity). Regulates E3
ubiquitin-protein ligase activity of RNF19AGene Wiki entry for VCP (Valosin-containing_protein) |
Genomic Location
for VCP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the VCP gene 
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13-p12VCP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M035046:
(about GC identifiers)
Start:
|
35,046,560 bp from pter |
End:
|
35,062,598 bp from pter |
Size:
|
16,039 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins
for VCP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TERA_HUMAN, P55072 (See
protein sequence)Recommended Name: Transitional endoplasmic reticulum ATPase Size: 806 amino acids; 89322 Da
Subunit: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial
symmetry. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer
that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in
phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a
heterodimer of NPLOC4 and UFD1L, binding to this heterodimer inhibits Golgi-membrane fusion.
Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a
ternary complex containing NPLOC4, UFD1L and VCP. Interacts with NSFL1C-like protein p37; the
complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum
biogenesis (By similarity). Interacts with SELS/VIMP and SYVN1, as well as with DERL1, DERL2 and
DERL3; which probably transfer misfolded proteins from the ER to VCP. Interacts with SVIP.
Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation
composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXD2 and RNF19A.
Interacts with CASR. Interacts with UBXN6 and UBE4B
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Present in the neuronal hyaline inclusion
bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in
the Lewy bodies specifically found in neurons from Parkinson disease patients
PDB structures from  and Proteopedia  :3EBB (3D)
Secondary accessions: Q969G7Post-translational modifications:
Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation (By
similarity). Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009057.1
ENSEMBL proteins: ENSP00000351777
Human Recombinant Proteins  OriGene Purified Recombinant Human Protein: VCP
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VCP:
Assays for VCP: | Protein
Domains/
Families
for VCP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P55072
ProtoNet protein and cluster: P55072 2 Blocks protein families: IPB003338 AAA ATPase VAT IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Similarity: Belongs to the AAA ATPase family | Gene Function
for VCP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007126
 Applied Biosystems Silencer® siRNAs for VCP
 Sigma-Aldrich siRNA and siRNA Panels for VCP
Sigma-Aldrich shRNA Panels and shRNA for VCP
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_007126
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007126
untagged cDNA clone in CMV expression vector: NM_007126
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_007126
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly
after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The
transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm
transition vesicles which derive from part-rough, part-smooth transitional elements of the
endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary
complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the
proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and
is necessary for the formation of a closed nuclear envelope (By similarity). Regulates E3
ubiquitin-protein ligase activity of RNF19AGenatlas biochemistry entry for VCP:valosin-containing protein,bound with high affinity to clathrin2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Vcp):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions
for VCP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for VCP (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for VCP
5/60 Interacting proteins for VCP (ENSP000003517773 P550721, 2) via UniProtKB, MINT, and/or STRING (see all 60
)About this table
5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
): About this table
|
Drugs & Compounds
for VCP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for VCP
8  Novoseek chemical compound relationships for VCP gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ptdins(3)p |
47.76 |
1 |
12650639 (1) |
| atp |
38.71 |
28 |
12504076 (2), 12473691 (2), 12807884 (2), 12747802 (2) (see all 14) |
| adp |
35.04 |
6 |
12807884 (2), 12504076 (1), 10715114 (1), 18174159 (1) |
| calcium |
9.77 |
8 |
9405427 (1), 8648106 (1), 15306153 (1), 8672553 (1) |
| tyrosine |
3.87 |
16 |
11087817 (4), 12509440 (2), 11086075 (1), 17166906 (1) (see all 7) |
| superoxide |
0.00 |
2 |
17360763 (1), 15456787 (1) |
| lipid |
0.00 |
1 |
10205162 (1) |
| threonine |
0.00 |
1 |
16551632 (1) |
About this table
|
Transcripts
for VCP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007126
Sigma-Aldrich siRNA and siRNA Panels for VCP
Sigma-Aldrich shRNA Panels and shRNA for VCP
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_007126 REFSEQ mRNAs for VCP gene: NM_007126.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007126
OriGene GFP tagged cDNA clone in CMV expression vector: NM_007126
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007126
untagged cDNA clone in CMV expression vector: NM_007126
Additional cDNA sequence: AF100752.1 AF313486.1 AK307735.1 AK312310.1 AL137377.1 BC007562.1 BC096751.1 BC110913.1 BC121794.1 BC122550.1 CR606334.1 Z70768.1 24/56 DOTS entries (see all 56
): DT.92461598 DT.100878430 DT.100061017 DT.100878429 DT.121145904 DT.100878422 DT.92475957 DT.92017855 DT.91827473 DT.100878435 DT.100878436 DT.121146017 DT.100840391 DT.100878441 DT.92461619 DT.121145929 DT.121145989 DT.100716087 DT.99980507 DT.121145950 DT.100039142 DT.95186348 DT.92461603 DT.100878427 24/1276 AceView cDNA sequences (see all 1276
):BQ887290 BE042757 BU931926 BM825673 AI367802 BQ772812 BU180377 BE731292 BE042688 BU626439 BM818313 BM819082 BM793936 CF125017 BM826861 CA390875 BM988820 BX439775 BQ006698 BU553357 BQ890558 BQ647224 CB132350 BG479863
 highest scoring ESTs for VCP:AA172312 AF100752 AI017298 AL045207 AL520921 AL540610 AL554534 AW732580 AW732949 BE241601 Unigene Cluster for VCP: Valosin-containing protein Hs.529782 [show with all ESTs]Unigene Representative Sequence: NM_007126
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VCP (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for VCP
1 Ensembl transcript including schematic representation: ENST00000358901
|
Expression
for VCP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VCP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VCP
1 / 2 / 3 7 probe-sets matching VCP gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTGTAAAAGG
SOURCE GeneReport for Unigene cluster: Hs.529782
Expression variation in blood from EXPOLDB for VCP |
Orthologs
for VCP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VCP gene from 5/27 species (see all 27
)
About this table Species with no ortholog for VCP
ENSEMBL Gene Tree for VCP | Paralogs
for VCP(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for VCP gene
- SPATA5L12 SPATA52
|
SNPs/Variants
for VCP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VCP (up to first 250kb)
|
Disorders & Mutations
for VCP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601023 disorders: 167320 UniProtKB/Swiss-Prot: TERA_HUMAN, P55072
Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and
frontotemporal dementia (IBMPFD) [MIM:167320]; also known as muscular dystrophy, limb-girdle, with
Paget disease of bone or pagetoid amyotrophic lateral sclerosis or pagetoid neuroskeletal syndrome
or lower motor neuron degeneration with Paget-like bone disease. IBMPFD features adult-onset
proximal and distal muscle weakness (clinically resembling limb girdle muscular dystrophy),
early-onset Paget disease of bone in most cases and premature frontotemporal dementia10/28 Novoseek disease relationships for VCP gene (see all 28
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inclusion body myopathy |
95.39 |
43 |
17935506 (2), 19380227 (2), 15732117 (2), 17457594 (2) (see all 24) |
| frontotemporal dementia |
88.61 |
63 |
17279000 (3), 17457594 (3), 15732117 (3), 17618707 (3) (see all 27) |
| myopathy |
64.58 |
24 |
17763460 (3), 19208399 (2), 16822868 (1), 16199218 (1) (see all 10) |
| machado-joseph disease |
58.43 |
4 |
12351637 (1) |
| neurodegenerative diseases |
57.29 |
7 |
18208395 (2), 12759168 (1), 16317258 (1), 18798739 (1) (see all 6) |
| motor neuron disease |
57.22 |
2 |
12759168 (1) |
| dementia |
50.73 |
16 |
19380227 (2), 12759168 (1), 16932700 (1), 16199218 (1) (see all 11) |
| neurodegeneration |
50.54 |
5 |
11859409 (3), 19237541 (1) |
| werner syndrome |
46.96 |
2 |
17626287 (1), 15037256 (1) |
| alzheimers disease |
35.58 |
4 |
12759168 (1) |
About this table
GeneTests: VCP
Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia
Human Gene Mutation Database: VCP
Human Genome Epidemiology Navigator: VCP (1 document)
|
Medical News
for VCP(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for VCP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/202 PubMed articles for VCP gene (see all 202
):- A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. (PubMed id 15362974)1, 3, 4 McNeill H.... Cohen P. (2004)
- Physical and functional interaction between dorfin and valosin- containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. (PubMed id 15456787)1, 3, 4 Ishigaki S.... Sobue G. (2004)
- Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene. (PubMed id 16247064)1, 3, 4 Haubenberger D.... Zimprich A. (2005)
- Mutant valosin-containing protein causes a novel type of frontotemporal dementia. (PubMed id 15732117)1, 3, 4 Schroeder R.... Thal D.R. (2005)
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)1, 2, 3 Druck T....Keen J.H. (1995)
- Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. (PubMed id 15034582)1, 3, 4 Watts G.D.J.... Kimonis V.E. (2004)
- An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. (PubMed id 7553851)1, 2, 3 Rabouille C....Warren G. (1995)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)3, 4 Matsuoka S.... Elledge S.J. (2007)
- Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PubMed id 16449189)3, 4 Oda Y.... Mori K. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
|
Search for VCP
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VCP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VCP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VCP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for VCP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for VCP:
 | |
 | | | | |
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 |  |  | |
 | Antibodies & Assays for VCP |
| | | Recombinant Proteins
(VCP) | | | Antibodies (VCP) |
| | | | Search Tocris compounds for VCP |
|
 |
 | | | | Antibodies for VCP |
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Incremental update: 13 Oct 2009
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