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Aliases for VCP Gene

Aliases for VCP Gene

  • Valosin Containing Protein 2 3 5
  • 15S Mg(2+)-ATPase P97 Subunit 3 4
  • Valosin-Containing Protein 2 4
  • TER ATPase 3 4
  • Transitional Endoplasmic Reticulum ATPase 3
  • EC 3.6.4.6 4
  • CDC48 3
  • TERA 3
  • P97 3

External Ids for VCP Gene

Previous GeneCards Identifiers for VCP Gene

  • GC09M035368
  • GC09M035225
  • GC09M035046
  • GC09M035011

Summaries for VCP Gene

Entrez Gene Summary for VCP Gene

  • This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

GeneCards Summary for VCP Gene

VCP (Valosin Containing Protein) is a Protein Coding gene. Diseases associated with VCP include Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 1 and Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia. Among its related pathways are DNA Damage and Ovarian tumor domain proteases. GO annotations related to this gene include poly(A) RNA binding and receptor binding.

UniProtKB/Swiss-Prot for VCP Gene

  • Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via Lys-63-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559).

Gene Wiki entry for VCP Gene

Additional gene information for VCP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCP Gene

Genomics for VCP Gene

Regulatory Elements for VCP Gene

Enhancers for VCP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H034987 1.6 FANTOM5 ENCODE dbSUPER 30.8 +80.0 79970 10 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS DEK SP3 VCP UBAP2 ARHGEF39 TPM2 FANCG CCDC107 TLN1 YBX1P10 PIGO FAM205A
GH09H035656 1.7 Ensembl ENCODE dbSUPER 21.1 -587.7 -587717 9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ARHGEF39 VCP RGP1 C9orf131 PIGO RN7SL22P NPR2 YBX1P10 RECK ENSG00000230074
GH09H035069 1.3 ENCODE dbSUPER 25.7 +1.4 1355 4 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS SP3 CEBPZ VCP FANCG TMEM8B FAM205A C9orf131 ENSG00000228352 ATP8B5P PIGO NPR2 RN7SL338P
GH09H034999 1.3 Ensembl ENCODE dbSUPER 20.7 +72.2 72221 3 PKNOX1 TAL1 ETV1 CEBPG BATF FOSL1 TCF12 CTBP1 GATA2 NCOR1 VCP FANCG C9orf131 PHF24 PIGO ENSG00000234181 STOML2 GC09P034997 ENSG00000279489
GH09H035078 1 ENCODE 21.3 -6.2 -6205 2 HDGF ATF1 ARID4B SIN3A DMAP1 YY1 ETS1 ZNF121 SLC30A9 GLIS2 VCP FANCG STOML2 FAM214B PIR34260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VCP on UCSC Golden Path with GeneCards custom track

Promoters for VCP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234593 1249 2001 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS SP3 CEBPZ

Genomic Location for VCP Gene

Chromosome:
9
Start:
35,056,064 bp from pter
End:
35,073,249 bp from pter
Size:
17,186 bases
Orientation:
Minus strand

Genomic View for VCP Gene

Genes around VCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCP Gene

Proteins for VCP Gene

  • Protein details for VCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55072-TERA_HUMAN
    Recommended name:
    Transitional endoplasmic reticulum ATPase
    Protein Accession:
    P55072
    Secondary Accessions:
    • B2R5T8
    • Q0V924
    • Q2TAI5
    • Q969G7
    • Q9UCD5

    Protein attributes for VCP Gene

    Size:
    806 amino acids
    Molecular mass:
    89322 Da
    Quaternary structure:
    • Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1, binding to this heterodimer inhibits Golgi-membrane fusion (PubMed:26471729). Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternary complex containing NPLOC4, UFD1 and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum biogenesis. Interacts with SELENOS and SYVN1, as well as with DERL1, DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP. Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXN4 and RNF19A. Interacts with CASR. Interacts with UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 and TRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts with RHBDD1 (via C-terminal domain). Interacts with SPRTN; leading to recruitment to stalled replication forks (PubMed:23042607, PubMed:23042605). Interacts with WASHC5. Interacts with UBOX5. Interacts (via N-terminus) with UBXN7, UBXN8, and probably several other UBX domain-containing proteins (via UBX domains); the interactions are mutually exclusive with VIM-dependent interactions such as those with AMFR and SELENOS. Forms a complex with UBQLN1 and UBXN4. Interacts (via the PIM motif) with RNF31 (via the PUB domain) (PubMed:24726327). Interacts with DDX58/RIG-I and RNF125; interaction takes place when DDX58/RIG-I is ubiquitinated via Lys-63-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). Interacts with BAG6 (PubMed:21636303). Interacts with UBXN10 (PubMed:26389662). Interacts with UBXN6; the interaction with UBXN6 is direct and competitive with UFD1 (PubMed:19174149, PubMed:19275885). Forms a ternary complex with CAV1 and UBXN6 (PubMed:21822278, PubMed:18656546, PubMed:19174149). Interacts with PLAA, UBXN6 and YOD1; may form a complex involved in macroautophagy (PubMed:27753622).

    Three dimensional structures from OCA and Proteopedia for VCP Gene

neXtProt entry for VCP Gene

Post-translational modifications for VCP Gene

  • ISGylated.
  • Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.
  • Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells.
  • Ubiquitination at posLast=6060, posLast=8181, posLast=109109, Lys148, Lys217, Lys231, posLast=251251, posLast=288288, posLast=295295, posLast=312312, posLast=336336, posLast=386386, posLast=486486, posLast=502502, posLast=505505, posLast=512512, posLast=524524, Lys529, Lys584, posLast=651651, Lys658, Lys668, Lys696, and Lys754
  • Modification sites at PhosphoSitePlus

Other Protein References for VCP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VCP (VCP)
  • Abcam antibodies for VCP

No data available for DME Specific Peptides for VCP Gene

Domains & Families for VCP Gene

Gene Families for VCP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

P55072

UniProtKB/Swiss-Prot:

TERA_HUMAN :
  • The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31.
  • Belongs to the AAA ATPase family.
Domain:
  • The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with VCP: view

Function for VCP Gene

Molecular function for VCP Gene

GENATLAS Biochemistry:
valosin-containing protein,bound with high affinity to clathrin
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via Lys-63-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559).

Enzyme Numbers (IUBMB) for VCP Gene

Phenotypes From GWAS Catalog for VCP Gene

Gene Ontology (GO) - Molecular Function for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 9452483
GO:0005524 ATP binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with VCP: view
genes like me logo Genes that share phenotypes with VCP: view

Human Phenotype Ontology for VCP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for VCP Gene

MGI Knock Outs for VCP:

Animal Model Products

  • Taconic Biosciences Mouse Models for VCP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VCP
  • Applied Biological Materials Clones for VCP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for VCP Gene

Localization for VCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCP Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with SPRTN (PubMed:23042605). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). {ECO:0000269 PubMed:15456787, ECO:0000269 PubMed:16168377, ECO:0000269 PubMed:22120668, ECO:0000269 PubMed:23042605, ECO:0000269 PubMed:27753622}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VCP gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
lysosome 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 9452483
GO:0005576 extracellular region TAS --
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA,IDA 27753622
genes like me logo Genes that share ontologies with VCP: view

Pathways & Interactions for VCP Gene

genes like me logo Genes that share pathways with VCP: view

Pathways by source for VCP Gene

SIGNOR curated interactions for VCP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair NAS 16140914
GO:0006302 double-strand break repair IDA 10855792
GO:0006457 protein folding TAS --
GO:0006479 protein methylation TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with VCP: view

Drugs & Compounds for VCP Gene

(16) Drugs for VCP Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
Phenethyl isothiocyanate Investigational Pharma Target 12
ATP Nutra Agonist 0

(5) Additional Compounds for VCP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) ApexBio Compounds for VCP Gene

Compound Action Cas Number
CB-5083 p97 inhibitor 1542705-92-9
DBeQ P97 ATPase inhibitor 177355-84-9
NMS-873 VCP/p97 inhibitor,selective and allosteric 1418013-75-8
genes like me logo Genes that share compounds with VCP: view

Drug Products

Transcripts for VCP Gene

Unigene Clusters for VCP Gene

Valosin containing protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VCP
  • Applied Biological Materials Clones for VCP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VCP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5: - - - - -
SP6: - - -
SP7:

ExUns: 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for VCP Gene

GeneLoc Exon Structure for
VCP
ECgene alternative splicing isoforms for
VCP

Expression for VCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VCP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VCP Gene



Protein tissue co-expression partners for VCP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VCP Gene:

VCP

SOURCE GeneReport for Unigene cluster for VCP Gene:

Hs.529782

Evidence on tissue expression from TISSUES for VCP Gene

  • Nervous system(5)
  • Lung(4.8)
  • Liver(4.7)
  • Blood(4.6)
  • Skin(4.4)
  • Intestine(4.2)
  • Kidney(4.2)
  • Heart(3.7)
  • Eye(3.5)
  • Muscle(3.3)
  • Pancreas(3.2)
  • Adrenal gland(2.9)
  • Spleen(2.8)
  • Gall bladder(2.7)
  • Stomach(2.7)
  • Bone(2.4)
  • Lymph node(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for VCP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • abdominal wall
  • biliary tract
  • kidney
  • liver
  • stomach
Pelvis:
  • pelvis
  • prostate
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with VCP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VCP Gene

Orthologs for VCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCP 33 34
  • 99.34 (n)
oppossum
(Monodelphis domestica)
Mammalia VCP 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCP 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VCP 33 34
  • 93.59 (n)
cow
(Bos Taurus)
Mammalia VCP 33 34
  • 92.89 (n)
rat
(Rattus norvegicus)
Mammalia Vcp 33
  • 91.81 (n)
mouse
(Mus musculus)
Mammalia Vcp 33 16 34
  • 91.52 (n)
chicken
(Gallus gallus)
Aves VCP 33 34
  • 83.91 (n)
lizard
(Anolis carolinensis)
Reptilia VCP 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vcp 33
  • 80.99 (n)
Str.1287 33
African clawed frog
(Xenopus laevis)
Amphibia vcp-prov 33
zebrafish
(Danio rerio)
Actinopterygii vcp 33 34
  • 80.81 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9204 33
fruit fly
(Drosophila melanogaster)
Insecta TER94 33 34 35
  • 73.35 (n)
BG:DS06874.3 35
  • 33 (a)
CG12010 35
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005630 33
  • 70.33 (n)
worm
(Caenorhabditis elegans)
Secernentea cdc-48.1 34
  • 77 (a)
OneToMany
C06A1.1 35
  • 75 (a)
cdc-48.2 33 34
  • 68.31 (n)
K04D7.2a 35
  • 38 (a)
K04D7.2b 35
  • 38 (a)
prx-1 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC48 33 34
  • 63.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR158W 33
  • 63.87 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05676g 33
  • 62.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03340 33
  • 69.96 (n)
soybean
(Glycine max)
eudicotyledons Gma.4013 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7531 33
rice
(Oryza sativa)
Liliopsida Os03g0151800 33
  • 71.16 (n)
Os.4689 33
barley
(Hordeum vulgare)
Liliopsida Hv.848 33
wheat
(Triticum aestivum)
Liliopsida Ta.28850 33
corn
(Zea mays)
Liliopsida Zm.1177 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7152 34
  • 82 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00018 33
  • 67.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc48 33
  • 64.21 (n)
Species where no ortholog for VCP was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VCP Gene

ENSEMBL:
Gene Tree for VCP (if available)
TreeFam:
Gene Tree for VCP (if available)

Paralogs for VCP Gene

No data available for Paralogs for VCP Gene

Variants for VCP Gene

Sequence variations from dbSNP and Humsavar for VCP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs121909329 Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320], Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia (ALS14) [MIM:613954], Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320] 35,065,363(-) TGTCC(A/C/G)TGGTG reference, missense
rs121909330 Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320] 35,065,364(-) TTGTC(C/G/T)GTGGT reference, missense
rs121909331 Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320] 35,064,167(-) TAAGG(A/C)AATTG reference, missense
rs121909332 Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320] 35,067,910(-) GTGTA(C/G/T)GCCTA reference, missense
rs121909334 Pathogenic, Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia (ALS14) [MIM:613954], Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320] 35,065,255(-) CAAAC(A/G)AGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for VCP Gene

Variant ID Type Subtype PubMed ID
esv3620367 CNV gain 21293372
nsv1115172 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259

Variation tolerance for VCP Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VCP Gene

Human Gene Mutation Database (HGMD)
VCP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCP Gene

Disorders for VCP Gene

MalaCards: The human disease database

(36) MalaCards diseases for VCP Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search VCP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TERA_HUMAN
  • Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia (ALS14) [MIM:613954]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS14 may develop frontotemporal dementia. {ECO:0000269 PubMed:21145000, ECO:0000269 PubMed:23349634}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Charcot-Marie-Tooth disease 2Y (CMT2Y) [MIM:616687]: An autosomal dominant, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269 PubMed:25125609, ECO:0000269 PubMed:25878907}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1) [MIM:167320]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:15034582, ECO:0000269 PubMed:15732117, ECO:0000269 PubMed:16247064, ECO:0000269 PubMed:16321991, ECO:0000269 PubMed:17935506, ECO:0000269 PubMed:20104022, ECO:0000269 PubMed:20335036, ECO:0000269 PubMed:20512113, ECO:0000269 PubMed:21822278, ECO:0000269 PubMed:23349634, ECO:0000269 PubMed:25125609, ECO:0000269 PubMed:25878907, ECO:0000269 PubMed:27209344, ECO:0000269 PubMed:27753622}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for VCP

Genetic Association Database (GAD)
VCP
Human Genome Epidemiology (HuGE) Navigator
VCP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VCP
genes like me logo Genes that share disorders with VCP: view

No data available for Genatlas for VCP Gene

Publications for VCP Gene

  1. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. (PMID: 20104022) Tresse E … Taylor JP (Autophagy 2010) 3 4 22 60
  2. Exome sequencing reveals VCP mutations as a cause of familial ALS. (PMID: 21145000) Johnson JO … Traynor BJ (Neuron 2010) 3 4 45 60
  3. No association of common VCP variants with sporadic frontotemporal dementia. (PMID: 17618707) Schumacher A … Riemenschneider M (Neurobiology of aging 2009) 3 22 45 60
  4. Ubxd1 is a novel co-factor of the human p97 ATPase. (PMID: 18656546) Madsen L … Hartmann-Petersen R (The international journal of biochemistry & cell biology 2008) 3 4 22 60
  5. Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. (PMID: 17935506) Watts GD … Kimonis VE (Clinical genetics 2007) 3 4 22 60

Products for VCP Gene

  • Addgene plasmids for VCP

Sources for VCP Gene

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