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VCL Gene

protein-coding GIFtS: 69

GC10P075427

vinculin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CMD1W ^², ⁵
MVCL ^²
Metavinculin ^³
OTTHUMP00000019861 ^²
OTTHUMP00000043885 ^²
metavinculin ^²
vinculin ^²

External Ids
HGNC: 12665¹
Entrez Gene: 7414²
UniProtKB: P18206³
Ensembl: ENSG00000035403⁷

Search outside databases for aliases for VCL gene

Previous GC identifers: GC10P074712 GC10P074861 GC10P075650 GC10P075102

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VCL:

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is

thought to function as one of several interacting proteins involved in anchoring F-actin to the

membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy

is a disorder characterized by ventricular dilation and impaired systolic function, resulting in

congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have

been found for this gene, but the biological validity of some variants has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: VINC_HUMAN, P18206

Function: Involved in cell adhesion. May be involved in the attachment of the actin-based

microfilaments to the plasma membrane. May also play important roles in cell morphology and

locomotion

Gene Wiki entry for VCL (Vinculin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VCL gene

Entrez Gene cytogenetic band: 10q22.2 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22.1-q23

VCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P075427: (about GC identifiers)

Start:	75,427,878 bp from pter
End:	75,549,924 bp from pter
Size:	122,047 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VINC_HUMAN, P18206 (See protein sequence)

Recommended Name: Vinculin

Size: 1134 amino acids; 123799 Da

Subunit: Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity).

Interacts with TLN1. Interacts with SYNM

Subcellular location: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane;

Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of adhesion plaques

PDB structures from and Proteopedia :

1RKC (3D)

1RKE (3D)

1SYQ (3D)

1TR2 (3D)

1YDI (3D)

2GWW (3D)

2HSQ (3D)

2IBF (3D)

Secondary accessions: Q16450 Q5SWX2 Q7Z3B8 Q8IXU7

Alternative splicing: 3 isoforms: P18206-1 P18206-2 P18206-3

Post-translational modifications:

Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated

platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor

on localization to focal adhesion plaques (By similarity)¹

Aceylated; mainly by myristic acid but also small amount of palmitic acid (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003364.1 NP_054706.1

ENSEMBL proteins:

ENSP00000211998 ENSP00000361841

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Vinculin)
	Human Recombinant Proteins from Abnova (VCL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005911	cell-cell junction	ISS	--
GO:0005912	adherens junction	ISS	--
GO:0005925	focal adhesion	ISS	--

About this table

Antibodies for VCL:

	Invitrogen Antibodies for VCL
	Millipore Mono- and Polyclonal Antibodies for the study of VCL
	Sigma-Aldrich Antibody Arrays and Antibodies for VCL
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Vinculin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VCL)
	Novus Biologicals Antibodies for VCL

Assays for VCL:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of VCL
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18206

ProtoNet protein and cluster: P18206

UniProtKB/Swiss-Prot: VINC_HUMAN, P18206

Similarity: Belongs to the vinculin/alpha-catenin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VCL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003373

Applied Biosystems Silencer® siRNAs for VCL

Sigma-Aldrich siRNA and siRNA Panels for VCL

Sigma-Aldrich shRNA Panels and shRNA for VCL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003373
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003373
untagged cDNA clones in CMV expression vector (see all 2): NM_003373

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014000

UniProtKB/Swiss-Prot: VINC_HUMAN, P18206

Function: Involved in cell adhesion. May be involved in the attachment of the actin-based

microfilaments to the plasma membrane. May also play important roles in cell morphology and

locomotion

Genatlas biochemistry entry for VCL:

vinculin,130kDa,component of adherens type of cell junction (catenin family)

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vcl):

	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle
nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	NOT actin binding	IDA	7816144
GO:0005198	structural molecule activity	IEA	--
GO:0016491	oxidoreductase activity	ISS	--
GO:0045294	alpha-catenin binding	IPI	9700171

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for VCL (Your Favorite Gene powered by Ingenuity) (see all 6 )

Leukocyte Extravasation Signaling
Inositol Metabolism
Tight Junction Signaling
VEGF Signaling
Actin Cytoskeleton Signaling

GeneDecks VCL for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VCL

5/87 Interacting proteins for VCL (ENSP00000211998³ P18206^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 87 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLN1 TLN1 (xeno)	P54939¹	EBI-716775, EBI-1035421
PRPF40A	O75400²	MINT-61876
TRIP6	Q15654²	MINT-68320
YWHAZ	P63104²	MINT-3318937
CDH1	ENSP00000268794³	STRING (score=.999)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	16130169
GO:0007155	cell adhesion	TAS	15501673
GO:0030032	lamellipodium assembly	ISS	--
GO:0030336	negative regulation of cell migration	TAS	15494027
GO:0043297	apical junction assembly	IMP	9700171

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VCL
10/40 Novoseek chemical compound relationships for VCL gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphotyrosine	71.14	28	10318759 (2), 12584242 (2), 7507854 (1), 7518470 (1) (see all 25)
phalloidin	62.07	5	11581207 (1), 9224767 (1), 10438068 (1), 8392930 (1) (see all 5)
tyrosine	61.35	62	15229287 (7), 7691054 (4), 8288618 (2), 9364324 (2) (see all 43)
swinholide a	56.62	2	9178097 (2)
cytochalasin	42.79	1	1629252 (1)
titanium	40.74	6	15472401 (2), 1722250 (1), 7512646 (1), 17628662 (1)
pip2	39.06	11	8288618 (4), 9560340 (3), 15037311 (1)
matrigel	35.05	1	8773143 (1)
cytochalasin b	35.00	2	8843917 (1), 2169493 (1)
sodium orthovanadate	29.46	1	11159014 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VCL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003373

Sigma-Aldrich siRNA and siRNA Panels for VCL

Sigma-Aldrich shRNA Panels and shRNA for VCL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003373 NM_014000

REFSEQ mRNAs for VCL gene (2 alternative transcripts):

NM_003373.3 NM_014000.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003373 NM_014000

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003373
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003373
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003373

Additional cDNA sequence:

AK055524.1 AK126978.1 AK296509.1 AK300280.1 AK304823.1 AL832130.1 BC013847.1 BC039174.1

CR612677.1 M33308.1

24/26 DOTS entries (see all 26 ):

DT.91768787 DT.100725860 DT.92411715 DT.91768786 DT.101959960 DT.87008295 DT.95095432 DT.95366359

DT.91825146 DT.95159491 DT.100030402 DT.121291153 DT.100030408 DT.100030403 DT.100827836 DT.100827838

DT.100827845 DT.121291034 DT.121291095 DT.40225418 DT.86846851 DT.91650533 DT.91812583 DT.95340721

24/504 AceView cDNA sequences (see all 504 ):

BU557072 BM787152 BC013847 AW589920 W76280 AU133247 BM738572 BC039174

AU133271 BQ898452 CN482073 CA393075 AL708715 AU131827 BU507716 BM737598

AU102359 CB267748 CA489202 BM791106 BF034214 CN483080 BF992633 BM819220

highest scoring ESTs for VCL:

M33308 AA031688 AA031689 AA036840 AA045285 AA046566 AA090531 AA099284 AA132058 AA132202

Unigene Cluster for VCL:

Vinculin

Hs.643896 [show with all ESTs]

Unigene Representative Sequence: NM_014000

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for VCL (see all 12 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·	17b	·
SP1:					-																																												-
SP2:																																																	-
SP3:																																																	-
SP4:
SP5:					-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-						-

ExUns:	17c	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	·	24c	·	24d
SP1:					-				-		-				-
SP2:					-				-		-				-
SP3:					-						-				-
SP4:									-		-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for VCL

2 Ensembl transcripts including schematic representations:

ENST00000211998 ENST00000372755

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VCL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VCL

¹ / ² / ³

5 probe-sets matching VCL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36601_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M33308	1.00	1.00	1.00	1
200930_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA156675	0.80	1.00	0.91	1
200931_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014000	0.60	1.00	0.82	1
200930_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200931_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTGCTCTCC

SOURCE GeneReport for Unigene cluster: Hs.643896
Expression variation in blood from EXPOLDB for VCL
UniProtKB/Swiss-Prot: VINC_HUMAN, P18206
Tissue specificity: Metavinculin is muscle-specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VCL gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	VCL¹	--	vinculin	99.88(n) 100(a)	450531 XM_507854.2 XP_507854.2
cow (Bos taurus)	VCL¹	--	vinculin	94.3(n) 99.12(a)	783645 XM_001252006.1 XP_001252007.1
rat (Rattus norvegicus)	Vcl¹	--	vinculin	91.03(n) 98.32(a)	305679 XM_223781.4 XP_223781.4
mouse (Mus musculus)	Vcl^{1, 5}	14 (2.50 cM)⁵	vinculin^{1, 5}	89.46(n)¹ 96.15(a)¹	22330¹ NM_009502.4¹ NP_033528.3¹ AA571387⁵ AB041262⁵ (see all 17)
chicken (Gallus gallus)	VCL¹	--	vinculin	79.96(n) 92.12(a)	396422 NM_205441.1 NP_990772.1

About this table Species with no ortholog for VCL

ENSEMBL Gene Tree for VCL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VCL gene

CTNNAL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/553 NCBI SNPs in VCL are shown (see all 553 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs703258^1,2	A,C,F,H,O	75549517(-)	`TCATTT/ATAAAG`	2	--	ut3¹		11		NA EA MN EU WA	996
--	rs7914216^1,2	A,C	75426186(+)	`caggcA/Gcctgc`	2	--	ng5¹		0	--	--	--	--
--	rs16931179^1,2	C,F	75541728(+)	`TGCGGC/TCGATG`	2	A/V	mis¹ int¹ ese³		7		NA EU EA WA	562
	rs3812625^1,2	A,C	75427708(+)	`CCCTTA/GGGAAT`	2	--	ng5¹		0	--	--	--	--
	rs4511236^1,2	H	75426510(+)	`CGAATT/CTGAAG`	2	--	ng5¹		4		EU EA WA	418
--	rs16408^1,2	F	75548921(+)	`TCTCC-/TATATCC`	2	--	ut3¹		4		EU NA EA	342
	rs3812624^1,2	C	75427586(+)	`GCGGGA/GCCAGC`	2	--	ng5¹		0	--	--	--	--
	rs2131956^1,2	A,C,F,H	75541741(-)	`GGGAAC/GCCAGC`	2	G/G	syn¹ int¹ ese³		7		NA EA EU	504
	rs767809^1,2	A,C,F,H	75535071(+)	`TCCCCG/AATGGT`	2	P/P	syn¹		10		MN EA NA EU WA	2248
	rs7904077^1,2	F,H	75524224(+)	`GGAGTC/TGGTAA`	2	V/V	syn¹		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for VCL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 193065 disorders: 611407

UniProtKB/Swiss-Prot: VINC_HUMAN, P18206

Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:611407].

Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic

function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature

death

10/41 Novoseek disease relationships for VCL gene (see all 41 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dilated cardiomyopathy	43.28	17	8712941 (3), 11815424 (2), 7774871 (1), 16236538 (1) (see all 11)
muscular dystrophy becker	40.05	1	9466596 (1)
shigellosis	25.27	2	10021367 (1), 9298981 (1)
darier disease	19.89	1	7537767 (1)
muscular dystrophy duchenne	14.56	1	1513465 (1)
hypertrophy	13.81	4	16949038 (1)
cardiomyopathy	13.04	2	16236538 (1), 16712796 (1)
pemphigus vulgaris	12.95	1	18327013 (1)
metastasis	7.14	4	9385927 (2), 16688788 (1), 8639463 (1)
pemphigoid bullous	6.14	1	18327013 (1)

About this table

1 PharmGKB disease relationship for VCL gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

GeneTests: VCL

Dilated Cardiomyopathy

Human Gene Mutation Database: VCL
Human Genome Epidemiology Navigator: VCL (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/552 PubMed articles for VCL gene (see all 552 ):

An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert. (PubMed id 1339348)^{2, 3, 4} Koteliansky V.E.... Small J.V. (1992)
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading. (PubMed id 15229287)^{1, 3, 4} Zhang Z....Haimovich B. (2004)
Human alpha-synemin interacts directly with vinculin and metavinculin. (PubMed id 18028034)^{1, 3, 4} Sun N....Robson R.M. (2008)
Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy. (PubMed id 16236538)^{1, 3, 4} Vasile V.C....Ackerman M.J. (2006)
A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy. (PubMed id 16712796)^{1, 3, 4} Vasile V.C.... Ackerman M.J. (2006)
Structural basis for amplifying vinculin activation by talin. (PubMed id 15070891)^{1, 3, 4} Izard T. and Vonrhein C. (2004)
Vinculin activation by talin through helical bundle conversion. (PubMed id 14702644)^{1, 3, 4} Izard T.... Bois P.R.J. (2004)
Complete sequence of human vinculin and assignment of the gene to chromosome 10. (PubMed id 2116004)^{1, 3, 4} Weller P.A.... Critchley D.R. (1990)
Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. (PubMed id 8440716)^{1, 3, 4} Moiseyeva E.P.... Critchley D.R. (1993)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7414	HGNC: 12665	AceView: VCL	Ensembl:ENSG00000035403	euGenes: HUgn7414
ECgene: VCL	H-InvDB: VCL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for VCL	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=VCL
Wikipedia	http://en.wikipedia.org/wiki/Vinculin

Licensable Technologies for VCL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VCL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VCL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VCL		Antibodies for VCL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VCL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VCL)
	Antibodies (VCL)
	Chimera RNAi (VCL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Vinculin)
	Antibodies (Vinculin)

Search OriGene for VCL

Search Tocris compounds for VCL

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VCL

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VCL Gene at Home site.
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VCL Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for VCL

Summaries
for VCL

Genomic Location
for VCL

Proteins
for VCL

Protein Domains/
Families
for VCL

Gene Function
for VCL

Pathways & Interactions
for VCL

Drugs & Compounds
for VCL

Transcripts
for VCL

Expression
for VCL

Orthologs
for VCL

Paralogs
for VCL

SNPs/Variants
for VCL

Disorders & Mutations
for VCL

Medical News
for VCL

Publications
for VCL

Search for VCL

Genome Databases showing VCL

Other Databases showing VCL

Specialized Databases showing VCL

Licensable Technologies
for VCL

Services
for VCL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VCL Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor VCL

Summariesfor VCL

Genomic Locationfor VCL

Proteinsfor VCL

Protein Domains/Familiesfor VCL

Gene Functionfor VCL

Pathways & Interactionsfor VCL

Drugs & Compoundsfor VCL

Transcriptsfor VCL

Expression for VCL

Orthologsfor VCL

Paralogsfor VCL

SNPs/Variantsfor VCL

Disorders & Mutationsfor VCL

Medical Newsfor VCL

Publicationsfor VCL

Search for VCL

Genome Databases showing VCL

Other Databases showing VCL

Specialized Databases showing VCL

Licensable Technologiesfor VCL

Servicesfor VCL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VCL

Summaries
for VCL

Genomic Location
for VCL

Proteins
for VCL

Protein Domains/
Families
for VCL

Gene Function
for VCL

Pathways & Interactions
for VCL

Drugs & Compounds
for VCL

Transcripts
for VCL

Expression
for VCL

Orthologs
for VCL

Paralogs
for VCL

SNPs/Variants
for VCL

Disorders & Mutations
for VCL

Medical News
for VCL

Publications
for VCL

Licensable Technologies
for VCL

Services
for VCL