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Aliases for VCAN Gene

Aliases for VCAN Gene

  • Versican 2 3
  • Chondroitin Sulfate Proteoglycan 2 2 3 4
  • CSPG2 3 4 6
  • Chondroitin Sulfate Proteoglycan Core Protein 2 3 4
  • Glial Hyaluronate-Binding Protein 3 4
  • Large Fibroblast Proteoglycan 3 4
  • Versican Proteoglycan 2 3
  • ERVR 3 6
  • WGN1 3 6
  • GHAP 3 4
  • PG-M 3 4
  • WGN 3 6
  • Versican Core Protein 3

External Ids for VCAN Gene

Previous HGNC Symbols for VCAN Gene

  • CSPG2

Previous GeneCards Identifiers for VCAN Gene

  • GC05P082804
  • GC05P077975

Summaries for VCAN Gene

Entrez Gene Summary for VCAN Gene

  • This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for VCAN Gene

VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include wagner syndrome 1 and vcan-related vitreoretinopathy. Among its related pathways are Disease and ERK Signaling. GO annotations related to this gene include calcium ion binding and hyaluronic acid binding. An important paralog of this gene is HAPLN1.

UniProtKB/Swiss-Prot for VCAN Gene

  • May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid

Gene Wiki entry for VCAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAN Gene

Genomics for VCAN Gene

Regulatory Elements for VCAN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VCAN Gene

83,471,465 bp from pter
83,582,303 bp from pter
110,839 bases
Plus strand

Genomic View for VCAN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCAN Gene

Proteins for VCAN Gene

  • Protein details for VCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Versican core protein
    Protein Accession:
    Secondary Accessions:
    • P20754
    • Q13010
    • Q13189
    • Q15123
    • Q9UCL9
    • Q9UNW5

    Protein attributes for VCAN Gene

    3396 amino acids
    Molecular mass:
    372820 Da
    Quaternary structure:
    • Interacts with FBLN1.

    Alternative splice isoforms for VCAN Gene


neXtProt entry for VCAN Gene

Proteomics data for VCAN Gene at MOPED

Post-translational modifications for VCAN Gene

  • Phosphorylation sites are present in the extracellular medium
  • Glycosylation at Asn57, Asn330, Ser510, Thr516, Thr518, Thr522, Asn615, Thr627, Thr632, Ser641, Thr642, Thr643, Thr687, Thr689, Thr716, Thr751, Thr754, Asn782, Thr792, Thr799, Ser801, Asn809, Thr869, Thr886, Thr887, Ser888, Thr889, Ser976, Thr981, Thr1092, Thr1093, Ser1101, Ser1103, Thr1110, Thr1116, Thr1121, Thr1123, Ser1131, Ser1133, Thr1191, Ser1212, Thr1219, Thr1220, Ser1221, Asn1332, Asn1398, Thr1418, Thr1419, Asn1442, Asn1468, Thr1566, Thr1569, Asn1663, Ser1716, Thr1719, Thr1731, Thr1734, Ser1742, Ser1743, Thr1744, Thr1763, Ser1765, Thr1769, Ser1772, Ser1775, Thr1777, Thr1778, Thr1780, Asn1898, Ser1909, Tyr1917, Ser1925, Thr1926, Ser1935, Ser1942, Thr1943, Ser1945, Thr2036, Ser2058, Thr2059, Thr2063, Thr2069, Thr2083, Ser2085, Thr2086, Thr2091, Thr2152, Thr2153, Thr2159, Thr2160, Asn2179, Thr2194, Thr2200, Ser2203, Asn2272, Asn2280, Asn2360, Asn2385, Asn2392, Thr2416, Ser2417, Ser2422, Thr2448, Ser2455, Ser2456, Thr2457, Thr2458, Ser2473, Asn2496, Thr2503, Thr2505, Thr2509, Ser2515, Thr2516, Ser2530, Thr2531, Thr2540, Asn2628, Thr2656, Ser2661, Ser2699, Thr2701, Ser2781, Thr2784, Thr2785, Asn2934, Thr2950, Ser3024, Thr3025, Ser3029, Asn3067, Asn3369, and Asn3379
  • Modification sites at PhosphoSitePlus

Other Protein References for VCAN Gene

Antibody Products

No data available for DME Specific Peptides for VCAN Gene

Domains for VCAN Gene

Gene Families for VCAN Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing
  • HYALECTAN :Proteoglycans / Extracellular Matrix : Hyalectans

Suggested Antigen Peptide Sequences for VCAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P13611
  • Contains 1 C-type lectin domain.
  • Contains 2 EGF-like domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Contains 1 Sushi (CCP/SCR) domain.
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with VCAN: view

Function for VCAN Gene

Molecular function for VCAN Gene

UniProtKB/Swiss-Prot Function:
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid

Gene Ontology (GO) - Molecular Function for VCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 23601700
GO:0005539 glycosaminoglycan binding TAS 7528742
GO:0005540 hyaluronic acid binding IEA --
genes like me logo Genes that share ontologies with VCAN: view
genes like me logo Genes that share phenotypes with VCAN: view

Animal Models for VCAN Gene

MGI Knock Outs for VCAN:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCAN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VCAN Gene

Localization for VCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCAN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for VCAN Gene COMPARTMENTS Subcellular localization image for VCAN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with VCAN: view

Pathways for VCAN Gene

genes like me logo Genes that share pathways with VCAN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organismal development TAS 2583089
genes like me logo Genes that share ontologies with VCAN: view

Compounds for VCAN Gene

(1) HMDB Compounds for VCAN Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronic acid
  • hyaluronic acid

(22) Novoseek inferred chemical compound relationships for VCAN Gene

Compound -log(P) Hits PubMed IDs
neurocan 80 10
dermatan sulfate 74.6 12
glycosaminoglycan 74.4 9
chondroitin sulfate 73.2 24
keratan sulfate 67 5
genes like me logo Genes that share compounds with VCAN: view

Transcripts for VCAN Gene

Unigene Clusters for VCAN Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCAN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCAN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - -
SP6: -

ExUns: 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: -
SP2: -
SP3: -

Relevant External Links for VCAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VCAN Gene

mRNA expression in normal human tissues for VCAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VCAN Gene

This gene is overexpressed in Artery - Aorta (8.3), Artery - Coronary (7.4), and Whole Blood (6.5).

Protein differential expression in normal tissues for VCAN Gene

This gene is overexpressed in Amniocyte (16.9), Spinal cord (10.1), Frontal cortex (8.4), and Brain (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VCAN Gene

SOURCE GeneReport for Unigene cluster for VCAN Gene Hs.643801

mRNA Expression by UniProt/SwissProt for VCAN Gene

Tissue specificity: Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas
genes like me logo Genes that share expressions with VCAN: view

In Situ Assay Products

No data available for Expression partners for VCAN Gene

Orthologs for VCAN Gene

This gene was present in the common ancestor of animals.

Orthologs for VCAN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VCAN 35
  • 83.26 (n)
  • 74.77 (a)
  • 74 (a)
(Canis familiaris)
Mammalia VCAN 35
  • 83.58 (n)
  • 76.26 (a)
  • 75 (a)
(Mus musculus)
Mammalia Vcan 35
  • 76.67 (n)
  • 64.38 (a)
Vcan 16
Vcan 36
  • 64 (a)
(Pan troglodytes)
Mammalia VCAN 35
  • 99.37 (n)
  • 98.94 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Vcan 35
  • 75.7 (n)
  • 62.99 (a)
(Monodelphis domestica)
Mammalia VCAN 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia VCAN 36
  • 46 (a)
(Gallus gallus)
Aves VCAN 36
  • 28 (a)
(Anolis carolinensis)
Reptilia VCAN 36
  • 33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24776 35
(Danio rerio)
Actinopterygii -- 35
vcanb 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea clec-149 36
  • 25 (a)
Species with no ortholog for VCAN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VCAN Gene

Gene Tree for VCAN (if available)
Gene Tree for VCAN (if available)

Paralogs for VCAN Gene

Paralogs for VCAN Gene

genes like me logo Genes that share paralogs with VCAN: view

Variants for VCAN Gene

Sequence variations from dbSNP and Humsavar for VCAN Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8061 -- 83,581,164(-) AAATG(C/T)TCCTG utr-variant-3-prime
rs10233 -- 83,582,037(-) TAAAC(A/G)TACTG utr-variant-3-prime
rs10411 -- 83,582,112(-) CAACA(A/C)AGTGT utr-variant-3-prime
rs11525 -- 83,581,318(-) TTTTT(G/T)GCATG utr-variant-3-prime
rs11726 -- 83,581,863(-) AGTCT(C/T)ACTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VCAN Gene

Variant ID Type Subtype PubMed ID
nsv830366 CNV Gain 17160897
nsv4903 CNV Insertion 18451855
esv7817 CNV Gain 19470904
nsv830367 CNV Gain+Loss 17160897
nsv462227 CNV Loss 19166990

Relevant External Links for VCAN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAN Gene

Disorders for VCAN Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for VCAN Gene in MalaCards »

(4) Diseases for VCAN Gene including...

(1) OMIM Diseases for VCAN Gene (118661)


  • Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. {ECO:0000269 PubMed:16043844, ECO:0000269 PubMed:22739342}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). {ECO:0000269 PubMed:22739342}.

(22) Novoseek inferred disease relationships for VCAN Gene

Disease -log(P) Hits PubMed IDs
solar elastosis 55.3 2
vascular stenosis 46.8 1
aggressiveness 24.5 4
atherosclerosis 19.5 3
tumors 17.2 27

Relevant External Links for VCAN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with VCAN: view

No data available for University of Copenhagen DISEASES and Genatlas for VCAN Gene

Publications for VCAN Gene

  1. Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). (PMID: 1478664) Iozzo R.V. … McPherson J.D. (Genomics 1992) 2 3 4 23
  2. Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. (PMID: 7528742) Naso M.F. … Iozzo R.V. (J. Biol. Chem. 1994) 3 4 23
  3. Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry. (PMID: 7921538) Yao L.Y. … Sandell L.J. (Matrix Biol. 1994) 3 4 23
  4. Differential expression of versican isoforms in brain tumors. (PMID: 8627343) Paulus W. … Zimmermann D.R. (J. Neuropathol. Exp. Neurol. 1996) 3 4 23
  5. Isolation of a large aggregating proteoglycan from human brain. (PMID: 1429726) Perides G. … Bignami A. (J. Biol. Chem. 1992) 3 4 23

Products for VCAN Gene

Sources for VCAN Gene

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