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VCAN Gene

protein-coding GIFtS: 60

GC05P082804

versican
(Previous name: chondroitin sulfate proteoglycan 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CSPG2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CSPG2 ^², ³
DKFZp686K06110 ^²
ERVR ^²
GHAP ^³
PG-M ^¹, ², ³
WGN ^²
WGN1 ^²
versican ^²

Descriptions
Chondroitin sulfate proteoglycan core protein 2 ^³
Glial hyaluronate-binding protein ^³
Large fibroblast proteoglycan ^³
Wagner syndrome (erosive vitreoretinopathy) ^²
chondroitin sulfate proteoglycan 2 ^¹
chondroitin sulfate proteoglycan 2 (versican) ^²
versican proteoglycan ^²

External Ids
HGNC: 2464¹
Entrez Gene: 1462²
UniProtKB: P13611³
Ensembl: ENSG00000038427⁷

Search outside databases for aliases for VCAN gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611

Function: May play a role in intercellular signaling and in connecting cells with the extracellular

matrix. May take part in the regulation of cell motility, growth and differentiation. Binds

hyaluronic acid

Gene Wiki entry for VCAN (Versican)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q12-q14

VCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P082804: (about GC identifiers)

Start:	82,803,339 bp from pter
End:	82,912,737 bp from pter
Size:	109,399 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611 (See protein sequence)

Recommended Name: Versican core protein precursor

Size: 3396 amino acids; 372820 Da

Subunit: Interacts with FBLN1 (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Disappears after the cartilage development

Secondary accessions: P20754 Q13010 Q13189 Q15123 Q9UCL9 Q9UNW5

Alternative splicing: 5 isoforms: P13611-1 P13611-2 P13611-3 P13611-4 P13611-5 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001119808.1 NP_004376.2

ENSEMBL proteins:

ENSP00000265077 ENSP00000340062 ENSP00000345946 ENSP00000342768

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Versican)
	Human Recombinant Proteins from Abnova (CSPG2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	TAS	2583089

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Antibodies for VCAN:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of VCAN
	Sigma-Aldrich Antibodies for VCAN
	R&D Systems Antibodies for VCAN (Versican)
	Antibodies from Abcam (Versican), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for VCAN

Assays for VCAN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13611

ProtoNet protein and cluster: P13611

5/8 Blocks protein families (see all 8 ):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000436 Sushi domain/SCR domain/CCP module

IPB000538 Link domain

IPB001438 Type II EGF-like signature

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611

Similarity: Belongs to the aggrecan/versican proteoglycan family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 2 Link domains

Similarity: Contains 1 Sushi (CCP/SCR) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCAN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CSPG2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001126336

Applied Biosystems Silencer® siRNAs for VCAN

Sigma-Aldrich siRNA for VCAN

Sigma-Aldrich shRNA Panels and shRNA for VCAN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VCAN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001126336
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001126336
untagged cDNA clones in CMV expression vector (see all 2): NM_001126336

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004385

UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611

Function: May play a role in intercellular signaling and in connecting cells with the extracellular

matrix. May take part in the regulation of cell motility, growth and differentiation. Binds

hyaluronic acid

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005529	sugar binding	IEA	--
GO:0005540	hyaluronic acid binding	TAS	2583089

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for VCAN

5/63 Interacting proteins for VCAN (ENSP00000265077³ P13611²) via UniProtKB, MINT, and/or STRING (see all 63 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNR	ENSP00000263525³	STRING (score=.981)
FN1	ENSP00000323534³	STRING (score=.957)
THBS1	ENSP00000260356³	STRING (score=.947)
TGFB2	ENSP00000355896³	STRING (score=.936)
CD44	ENSP00000278385³	STRING (score=.928)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2583089
GO:0007275	multicellular organismal development	TAS	2583089
GO:0008037	cell recognition	TAS	2583089

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VCAN
10/15 Novoseek chemical compound relationships for VCAN gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurocan	75.61	7	11038354 (2), 10400671 (2), 15590670 (1), 8907541 (1) (see all 5)
chondroitin sulfate	74.40	36	10950950 (5), 12530013 (2), 7822336 (2), 16730906 (2) (see all 15)
glycosaminoglycan	74.35	12	8970376 (1), 7921538 (1), 16636652 (1), 11918305 (1) (see all 8)
keratan sulfate	68.10	6	10399179 (2), 11918305 (1), 16151708 (1), 11980843 (1)
dermatan	65.22	1	11474365 (1)
chondroitin	64.05	5	10950950 (1), 9474087 (1), 11474365 (1), 16118286 (1) (see all 5)
iduronic acid	55.51	2	12530013 (1), 16118286 (1)
tgf beta1	38.36	6	15599946 (3), 15302416 (2), 15336555 (1)
heparan sulfate	30.57	5	10399179 (2), 10950950 (1)
methanol	5.04	1	11980843 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCAN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CSPG2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001126336

Sigma-Aldrich siRNA for VCAN

Sigma-Aldrich shRNA Panels and shRNA for VCAN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001126336 NM_004385

REFSEQ mRNAs for VCAN gene (2 alternative transcripts):

NM_001126336.1 NM_004385.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001126336 NM_004385

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001126336
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001126336
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001126336

Additional cDNA sequence:

AB209491.1 AF084545.1 AK296285.1 AK299770.1 AK307642.1 BC050524.1 BX641036.1 D32039.1

J02814.1 U16306.1 U26555.1 X15998.1

16 DOTS entries:

DT.92004195 DT.97816723 DT.102833978 DT.449140 DT.92450898 DT.97772672 DT.100827290 DT.100827289

DT.95080321 DT.100728649 DT.120890777 DT.95309059 DT.100827284 DT.100827292 DT.100827297 DT.120890748

24/485 AceView cDNA sequences (see all 485 ):

AI659750 BX470574 BI494397 AI193987 BQ014389 AI418379 AU119394 BG166613

AW612845 AU131617 AI920899 AI130987 AI584053 BX493025 W79765 AA975415

AI589357 AI358578 BP373665 BX478912 AI094425 AU117457 AI867287 AI264950

Unigene Cluster for VCAN:

Versican

Hs.643801 [show with all ESTs]

Unigene Representative Sequence: NM_004385

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VCAN (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17	^
SP1:																	-						-		-		-		-		-		-
SP2:																	-		-		-		-		-		-		-		-		-
SP3:																															-		-
SP4:																															-		-								-
SP5:

ExUns:	18a	·	18b	^	19a	·	19b	·	19c	·	19d
SP1:	-
SP2:	-
SP3:	-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for VCAN

4 Ensembl transcripts including schematic representations:

ENST00000265077 ENST00000343200 ENST00000348134 ENST00000342785

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VCAN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VCAN

¹ / ²

14 probe-sets matching VCAN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38111_at²	U95-A	1	1.00	1.00	0.96	1.10	--	--	--	--	--
38112_g_at²	U95-A	1	1.00	1.00	0.98	0.96	--	--	--	--	--
31682_s_at²	U95-A	2	1.00	0.81	0.97	0.79	--	--	--	--	--
45718_at²	U95-B	1	0.31	1.00	0.97	1.17	--	--	--	--	--
204620_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
221731_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
211571_s_at²	U133-A	2	1.00	0.86	--	--	--	--	--	--	--
215646_s_at²	U133-A	2	1.00	0.59	--	--	--	--	--	--	--
204619_s_at²	U133-A	1	0.36	1.00	--	--	--	--	--	--	--
204620_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221731_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211571_s_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
215646_s_at²	U133Plus2	2	1.00	0.59	--	--	--	--	--	--	--
204619_s_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

GeneDecks VCAN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.643801
UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611
Tissue specificity: Cerebral white matter. Isoform V0 and isoform V1 are expressed in normal brain,
gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas; isoform V2 is restricted
to normal brain and gliomas; isoform V3 is found in all these tissues except medulloblastomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VCAN gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VCAN¹	--	versican	83.61(n) 76.35(a)	488922 XM_546039.2 XP_546039.2
chimpanzee (Pan troglodytes)	VCAN¹	--	versican	99.37(n) 98.94(a)	461766 XM_517667.2 XP_517667.2
cow (Bos taurus)	VCAN¹	--	versican	83.28(n) 74.71(a)	282662 NM_181035.2 NP_851378.1
rat (Rattus norvegicus)	Vcan¹	--	versican	75.44(n) 62.24(a)	114122 XM_215451.4 XP_215451.4
mouse (Mus musculus)	Vcan^{1, 5}	13 (55.00 cM)⁵	versican^{1, 5}	76.73(n)¹ 64.44(a)¹	13003¹ NM_001081249.1¹ NP_001074718.1¹ AA386896⁵ AK014525⁵ (see all 31)

About this table Species with no ortholog for VCAN

ENSEMBL Gene Tree for VCAN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VCAN gene

BCAN² ACAN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/605 NCBI SNPs in VCAN are shown (see all 605 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 294)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs309559^1,2	A,C,F,H,O	82869125(-)	`CTTTTC/TTGGCT`	1	K/R	mis¹ ese³ trp³		28	EA NA MN EU WA	2956
	rs188703^1,2	A,C,F,H,O	82870055(-)	`GACTAC/TGTGGG`	1	R/H	mis¹ ese³		12	MN EU EA WA NA	1282
	rs11726^1,2	A,C,F,H,O	82913438(-)	`AGTCTC/TACTTT`	2	--	ut3¹		5	MN EU EA	630
	rs2652098^1,2	C,F,H,O	82843828(-)	`CATCCG/AACAGC`	2	L/S	mis¹ ese³		12	EU EA WA NA	2478
	rs160277^1,2	A,C,F,H	82873387(-)	`ACCATC/AGGTTT`	1	Y/D	mis¹		20	EA NA EU WA	2958
	rs160278^1,2	A,C,F,H	82871480(-)	`TGTTAA/TAGTCT`	1	F/Y	mis¹		18	EA NA MN EU WA	2832
	rs15071^1,2	A,C,F	82913445(+)	`GACTCC/TTTCCC`	2	--	ut3¹		1	MN	184
	rs16900532^1,2	C,F,H	82873611(+)	`ATAAAC/ACCTGA`	1	K/N	mis¹ ese³		15	NA EU EA WA	1400
	rs3734094^1,2	C,F,H	82871521(-)	`AGATAC/GGAGTG`	1	V/L	mis¹ ese³		13	EA EU WA	2732
	rs2287926^1,2	C,F,H	82851164(+)	`TACTGG/ACAGTA`	1	D/G	mis¹ ese³		13	EA EU WA	2704

About this table

HapMap Linkage Disequilibrium images for VCAN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118661

UniProtKB/Swiss-Prot: CSPG2_HUMAN, P13611

Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a

dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with

fibrillary condensations and a preretinal avascular membrane. Other optical features include

progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia.

Systemic manifestations are absent in WGN

10/22 Novoseek disease relationships for VCAN gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
solar elastosis	57.16	2	7783424 (1), 10504457 (1)
vascular stenosis	48.50	1	16493581 (1)
aggressiveness	27.25	4	18383852 (1), 12534600 (1), 19269971 (1), 16730906 (1)
atherosclerosis	22.21	3	16845893 (1), 10397680 (1), 15539621 (1)
medulloblastoma	14.60	1	8627343 (1)
melanoma	12.50	18	19269971 (6), 15645431 (3), 12972299 (2), 16847433 (2) (see all 6)
tumors	9.69	23	19160015 (3), 15073129 (2), 16847433 (2), 8627343 (2) (see all 16)
metastasis	8.92	14	17065588 (2), 17446061 (2), 17163843 (1), 19160015 (1) (see all 8)
cancer	6.39	19	19160015 (5), 16730906 (2), 12530013 (1), 18383852 (1) (see all 10)
restenosis	4.55	2	11561759 (1), 10397680 (1)

About this table

GeneTests: VCAN

VCAN-Related Retinopathy

Human Gene Mutation Database: VCAN
Human Genome Epidemiology Navigator: VCAN (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/207 PubMed articles for VCAN gene (see all 207 ):

Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). (PubMed id 1478664)^{1, 2, 3, 4} Iozzo R.V.... McPherson J.D. (1992)
Isolation of a large aggregating proteoglycan from human brain. (PubMed id 1429726)^{1, 3, 4} Perides G.... Bignami A. (1992)
Versican/PG-M isoforms in vascular smooth muscle cells. (PubMed id 10397680)^{1, 3, 4} Lemire J.M....Wight T.N. (1999)
Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry. (PubMed id 7921538)^{1, 3, 4} Yao L.Y.... Sandell L.J. (1994)
Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome. (PubMed id 16043844)^{1, 3, 4} Miyamoto T.... Itakura M. (2005)
Differential expression of versican isoforms in brain tumors. (PubMed id 8627343)^{1, 3, 4} Paulus W.... Zimmermann D.R. (1996)
Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. (PubMed id 7528742)^{1, 3, 4} Naso M.F.... Iozzo R.V. (1994)
Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues. (PubMed id 7876137)^{3, 4} Zako M.... Kimata K. (1995)
A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican. (PubMed id 7806529)^{3, 4} Dours-Zimmermann M.T. and Zimmermann D.R. (1994)
Isolation and partial characterization of a glial hyaluronate-binding protein. (PubMed id 2466833)^{3, 4} Perides G.... Bignami A. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1462	HGNC: 2464	AceView: CSPG2	Ensembl:ENSG00000038427	euGenes: HUgn1462
ECgene: VCAN	H-InvDB: VCAN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_214

Licensable Technologies for VCAN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VCAN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VCAN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VCAN		Antibodies for VCAN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VCAN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CSPG2)
	Search for Antibodies
	Chimera RNAi (CSPG2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Versican)
	Antibodies (Versican)

Search OriGene for VCAN

Search Tocris compounds for VCAN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VCAN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VCAN Gene at Home site.
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VCAN Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for VCAN

Summaries
for VCAN

Genomic Location
for VCAN

Proteins
for VCAN

Protein Domains/
Families
for VCAN

Gene Function
for VCAN

Pathways & Interactions
for VCAN

Drugs & Compounds
for VCAN

Transcripts
for VCAN

Expression
for VCAN

Orthologs
for VCAN

Paralogs
for VCAN

SNPs/Variants
for VCAN

Disorders & Mutations
for VCAN

Medical News
for VCAN

Publications
for VCAN

Search for VCAN

Genome Databases showing VCAN

Other Databases showing VCAN

Specialized Databases showing VCAN

Licensable Technologies
for VCAN

Services
for VCAN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VCAN Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor VCAN

Summariesfor VCAN

Genomic Locationfor VCAN

Proteinsfor VCAN

Protein Domains/Familiesfor VCAN

Gene Functionfor VCAN

Pathways & Interactionsfor VCAN

Drugs & Compoundsfor VCAN

Transcriptsfor VCAN

Expression for VCAN

Orthologsfor VCAN

Paralogsfor VCAN

SNPs/Variantsfor VCAN

Disorders & Mutationsfor VCAN

Medical Newsfor VCAN

Publicationsfor VCAN

Search for VCAN

Genome Databases showing VCAN

Other Databases showing VCAN

Specialized Databases showing VCAN

Licensable Technologiesfor VCAN

Servicesfor VCAN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VCAN

Summaries
for VCAN

Genomic Location
for VCAN

Proteins
for VCAN

Protein Domains/
Families
for VCAN

Gene Function
for VCAN

Pathways & Interactions
for VCAN

Drugs & Compounds
for VCAN

Transcripts
for VCAN

Expression
for VCAN

Orthologs
for VCAN

Paralogs
for VCAN

SNPs/Variants
for VCAN

Disorders & Mutations
for VCAN

Medical News
for VCAN

Publications
for VCAN

Licensable Technologies
for VCAN

Services
for VCAN