Aliases for VCAM1 Gene
Aliases for VCAM1 Gene
External Ids for VCAM1 Gene
- HGNC: 12663
- Entrez Gene: 7412
- Ensembl: ENSG00000162692
- OMIM: 192225
- UniProtKB: P19320
Previous GeneCards Identifiers for VCAM1 Gene
- GC01P101976
- GC01P100366
- GC01P100476
- GC01P100648
- GC01P100897
- GC01P101185
- GC01P099309
Summaries for VCAM1 Gene
-
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for VCAM1 Gene
VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include Viral Encephalitis and Mooren's Ulcer. Among its related pathways are RANK Signaling in Osteoclasts and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is CD22.
UniProtKB/Swiss-Prot for VCAM1 Gene
-
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Additional gene information for VCAM1 Gene
- Monarch Initiative
- Search for VCAM1 at DataMed
- Search for VCAM1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAM1 Gene
Genomics for VCAM1 Gene
GeneHancer (GH) Regulatory Elements for VCAM1 Gene
Promoters and enhancers for VCAM1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I100719 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE dbSUPER | 571.6 | +1.3 | 1274 | 3 | ZNF687 EBF1 CEBPG DPF2 RELA POLR2A CEBPA IKZF1 NBN FOXP2 | VCAM1 ENSG00000228086 GPR88 GC01P100735 GC01P100677 | |
| GH01I100621 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 29.4 | -96.1 | -96087 | 4.4 | JUN CEBPG FEZF1 ZIC2 ZFHX2 GLIS2 POLR2A PATZ1 PRDM10 ATF7 | VCAM1 GPR88 LINC01349 RTCA RPL7AP17 | |
| GH01I100712 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 21.2 | -6.3 | -6276 | 1.5 | SRF ZNF316 CREB1 ATF7 ATF2 | PIR61471 VCAM1 GC01P100677 | |
| GH01I100785 | Enhancer | 1.1 | Ensembl ENCODE | 10.5 | +66.2 | 66245 | 1.3 | HDAC1 ATF1 TAF9B NFRKB CHAMP1 TCF12 ZNF766 CBX5 GATA2 E2F8 | VCAM1 GPR88 SLC30A7 GC01M100814 GC01P100735 | |
| GH01I100626 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 11.1 | -90.5 | -90517 | 5.8 | HDAC1 JUNB CEBPG BATF ATF2 ZFHX2 JUND POLR2A IKZF1 FOS | VCAM1 LINC01349 RPL7AP17 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VCAM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the VCAM1 gene promoter:
Regulatory Element Products
Genomic Locations for VCAM1 Gene
Genomic Locations for VCAM1 Gene
- chr1:100,719,640-100,739,045
- (GRCh38/hg38)
- Size:
- 19,406 bases
- Orientation:
- Plus strand
- chr1:101,185,196-101,204,601
- (GRCh37/hg19)
Genomic View for VCAM1 Gene
Genes around VCAM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.2 by Ensembl
- 1p21.2 by Entrez Gene
- 1p21.2 by HGNC
VCAM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCAM1 Gene
Proteins for VCAM1 Gene
-
Protein details for VCAM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19320-VCAM1_HUMAN
- Recommended name:
- Vascular cell adhesion protein 1
- Protein Accession:
- P19320
- A8K6R7
- B4DKS4
- E9PDD1
- Q6NUP8
Protein attributes for VCAM1 Gene
- Size:
- 739 amino acids
- Molecular mass:
- 81276 Da
- Quaternary structure:
-
- Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
Protein Expression for VCAM1 Gene
Post-translational modifications for VCAM1 Gene
- Sialoglycoprotein.
- Glycosylation at isoforms=2, 3273, posLast=365365, posLast=417417, posLast=463463, posLast=531531, and isoforms=2, 3561
Other Protein References for VCAM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for VCAM1 (VCAM-1/CD106)
-
Custom Antibody ServicesOriGene Antibodies for VCAM1
- TA700239
- TA600240
- TA600239
- TA590416
- TA590414
- TA590413
- CF502426
- TA502426
- CF502411
- TA502411
- CF502392
- TA502392
- CF502391
- TA502391
- CF502390
- TA502390
- CF502361
- TA502361
- CF502360
- TA502360
- TA350599
- TA336775
- TA328469
- TA328468
- TA326818
- TA320511
- TA320510
- SM178PT
- SM1178P
- SM1178FT
- SM1178F
- SM1178
- AP50835PU-N
- AP32710PU-N
- AP22317PU-S
- AP22317PU-N
- AP22317BT-S
- AP22317BT-N
- AM33018PU-N
- AM31329BT-N
- AM31306AF-N
- AM31190PU-N
- AM31190AF-N
- AM26718PU-N
- AM26158PU-N
- AM26158BT-N
- AM06443SU-N
- AM05549RP-N
- AM05549PU-T
- AM05549PU-N
- Novus Biologicals Antibodies for VCAM1
-
Abcam antibodies for VCAM1
-
Cloud-Clone Corp. Antibodies for VCAM1
- Invitrogen Antibodies for VCAM1
- antibodies-online: Search results for 739 available VCAM1 Antibodies ranked by validation data
- Compare Top VCAM1 Antibodies
-
Recommended
- 193 WB Antibodies (anti-human)
- 78 FACS Antibodies (anti-human)
- 42 IHC (p) Antibodies (anti-human)
- 33 IP Antibodies (anti-human)
- 15 IHC (fro) Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 LMNX Antibody (anti-human)
- 1 Purif Antibody (anti-human)
- 61 FACS Antibodies (anti-mouse)
- 56 WB Antibodies (anti-mouse)
- 47 IHC Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 13 IP Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IP Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 5 IF Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 17 FACS Antibodies (anti-rat)
- 38 WB Antibodies (anti-rat)
- 1 Neut Antibody (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- GeneTex VCAM1 antibody for VCAM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for VCAM1
- Sino Biological Antibodies for VCAM1
Protein Products
- R&D Systems Proteins and Enzymes for VCAM1 (VCAM-1/CD106)
- Search Origene for MassSpec and Protein Over-expression Lysates for VCAM1
- Origene Custom Protein Services for VCAM1
- Sino Biological Recombinant Proteins for VCAM1
- Sino Biological Cell Lysates for VCAM1
- ProSpec Recombinant Proteins for VCAM1
-
Cloud-Clone Corp. Proteins for VCAM1
- GeneTex Proteins for VCAM1
-
Abcam proteins for VCAM1
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for VCAM1 (VCAM-1/CD106)
- antibodies-online: Search results for 119 available VCAM1 Elisa Kits ranked by validation data
- Compare Top VCAM1 Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 5 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Hamster ELISA Kit
- 41 Human ELISA Kits
- 3 Monkey ELISA Kits
- 26 Mouse (Murine) ELISA Kits
- 11 Pig (Porcine) ELISA Kits
- 9 Rabbit ELISA Kits
- 15 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
No data available for DME Specific Peptides for VCAM1 Gene
Domains & Families for VCAM1 Gene
Gene Families for VCAM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
Protein Domains for VCAM1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VCAM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P19320UniProtKB/Swiss-Prot:
VCAM1_HUMAN :- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
- Domain:
-
- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Function for VCAM1 Gene
Molecular function for VCAM1 Gene
- GENATLAS Biochemistry:
- cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial sialoglycoprotein
- UniProtKB/Swiss-Prot Function:
- Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
- UniProtKB/Swiss-Prot Induction:
- By cytokines (e.g. IL-1, TNF-alpha).
Phenotypes From GWAS Catalog for VCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005178 | integrin binding | IEA,IMP | 19738201 |
| GO:0008131 | primary amine oxidase activity | IDA | 23474851 |
| GO:0050839 | cell adhesion molecule binding | IPI | 12082081 |
Phenotypes for VCAM1 Gene
- MGI mutant phenotypes for VCAM1:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for VCAM1:
Animal Models for VCAM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
- Search ViGene Biosciences for VCAM1
CRISPR Products
-
OriGene CRISPR knockouts for VCAM1
- genomics-online: gRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- Applied Biological Materials CRISPR for VCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- GenScript: Design CRISPR guide RNA sequences for VCAM1
miRNA for VCAM1 Gene
- miRTarBase miRNAs that target VCAM1
-
- hsa-mir-200a-3p (MIRT004007)
- hsa-mir-126-3p (MIRT004081)
- hsa-mir-155-5p (MIRT020917)
- bta-mir-145 (MIRT053908)
- bta-mir-181a (MIRT053974)
- hsa-mir-23c (MIRT504350)
- hsa-mir-23b-3p (MIRT504351)
- hsa-mir-23a-3p (MIRT504352)
- hsa-mir-130a-5p (MIRT504353)
- hsa-mir-190a-3p (MIRT504354)
- hsa-mir-6074 (MIRT504355)
- hsa-mir-5011-5p (MIRT504356)
- hsa-mir-1277-5p (MIRT504357)
- hsa-mir-6516-5p (MIRT533248)
- hsa-mir-4677-5p (MIRT533249)
- hsa-mir-3678-3p (MIRT533250)
- hsa-mir-1273h-3p (MIRT533251)
- hsa-mir-6844 (MIRT533252)
- hsa-mir-22-5p (MIRT533253)
- hsa-mir-2116-5p (MIRT533254)
- hsa-mir-2467-3p (MIRT533255)
- hsa-mir-96-3p (MIRT533256)
- hsa-mir-5694 (MIRT533257)
- hsa-mir-6856-3p (MIRT533258)
- hsa-mir-186-5p (MIRT533259)
- hsa-mir-5092 (MIRT610905)
- hsa-mir-519d-5p (MIRT619598)
- hsa-mir-3145-5p (MIRT619599)
- hsa-mir-548x-3p (MIRT635473)
- hsa-mir-548j-3p (MIRT635474)
- hsa-mir-548aq-3p (MIRT635475)
- hsa-mir-548am-3p (MIRT635476)
- hsa-mir-548aj-3p (MIRT635477)
- hsa-mir-548ah-3p (MIRT635478)
- hsa-mir-548ae-3p (MIRT635479)
- hsa-mir-7110-3p (MIRT707380)
- hsa-mir-6845-3p (MIRT707381)
- hsa-mir-136-5p (MIRT707382)
- hsa-mir-6769b-3p (MIRT707383)
- hsa-mir-4723-3p (MIRT707384)
- hsa-mir-3183 (MIRT707385)
- hsa-mir-3127-5p (MIRT715352)
- hsa-mir-3691-3p (MIRT715353)
- hsa-mir-6754-5p (MIRT715354)
- hsa-mir-4441 (MIRT715355)
- hsa-mir-4270 (MIRT715356)
- hsa-mir-211-3p (MIRT715357)
- hsa-mir-506-5p (MIRT715358)
- hsa-mir-181b-5p (MIRT715359)
- hsa-mir-4262 (MIRT715360)
- hsa-mir-181d-5p (MIRT715361)
- hsa-mir-181c-5p (MIRT715362)
- hsa-mir-181a-5p (MIRT715363)
- hsa-mir-1247-3p (MIRT761590)
- hsa-mir-1273e (MIRT761880)
- hsa-mir-15a-3p (MIRT762922)
- hsa-mir-1827 (MIRT763148)
- hsa-mir-1910-3p (MIRT763364)
- hsa-mir-219b-3p (MIRT763927)
- hsa-mir-302f (MIRT764534)
- hsa-mir-3612 (MIRT765966)
- hsa-mir-377-5p (MIRT767499)
- hsa-mir-3929 (MIRT767821)
- hsa-mir-4252 (MIRT768066)
- hsa-mir-4257 (MIRT768187)
- hsa-mir-4419b (MIRT768817)
- hsa-mir-4433a-3p (MIRT769055)
- hsa-mir-4459 (MIRT769374)
- hsa-mir-4478 (MIRT769568)
- hsa-mir-4529-5p (MIRT770060)
- hsa-mir-455-3p (MIRT770463)
- hsa-mir-4649-3p (MIRT770691)
- hsa-mir-4683 (MIRT770963)
- hsa-mir-4722-5p (MIRT771604)
- hsa-mir-4768-3p (MIRT772159)
- hsa-mir-485-5p (MIRT772661)
- hsa-mir-6086 (MIRT775629)
- hsa-mir-6499-3p (MIRT776408)
- hsa-mir-650 (MIRT776724)
- hsa-mir-6511a-5p (MIRT776863)
- hsa-mir-665 (MIRT777643)
- hsa-mir-6807-5p (MIRT779629)
- hsa-mir-6808-5p (MIRT779734)
- hsa-mir-6884-5p (MIRT781049)
- hsa-mir-6888-5p (MIRT781114)
- hsa-mir-6893-5p (MIRT781266)
- hsa-mir-7160-5p (MIRT781654)
- hsa-mir-940 (MIRT782959)
miRNA Products
- Search ViGene Biosciences for VCAM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
- genomics-online: shRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
Clone Products
- Sino Biological Human cDNA Clone for VCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for VCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for VCAM1 (VCAM-1/CD106)
Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor and PureStem Z11, Meso Progenitor for VCAM1
-
Horizon Cell Lines for VCAM1
-
ViGene Biosciences adenoviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VCAM1 Gene
Localization for VCAM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCAM1 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002102 | podosome | IDA | 15220135 |
| GO:0005615 | extracellular space | IDA,IEA | 9290466 |
| GO:0005769 | early endosome | IDA | 23474851 |
| GO:0005783 | endoplasmic reticulum | IDA | 23474851 |
| GO:0005794 | Golgi apparatus | IDA | 23474851 |
Pathways & Interactions for VCAM1 Gene
Pathways by source for VCAM1 Gene
2 Cell Signaling Technology pathways for VCAM1 Gene
7 BioSystems pathways for VCAM1 Gene
10 Reactome pathways for VCAM1 Gene
4 GeneGo (Thomson Reuters) pathways for VCAM1 Gene
3 R&D Systems pathways for VCAM1 Gene
3 Qiagen pathways for VCAM1 Gene
Interacting Proteins for VCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0002526 | acute inflammatory response | IEA | -- |
| GO:0002544 | chronic inflammatory response | IEA | -- |
| GO:0007155 | cell adhesion | IDA,IEA | 16809613 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IDA | 1715889 |
No data available for SIGNOR curated interactions for VCAM1 Gene
Transcripts for VCAM1 Gene
mRNA/cDNA for VCAM1 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (152) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VCAM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VCAM1
- genomics-online: gRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- Applied Biological Materials CRISPR for VCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- GenScript: Design CRISPR guide RNA sequences for VCAM1
miRNA Products
- Search ViGene Biosciences for VCAM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
- genomics-online: shRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
Clone Products
- Sino Biological Human cDNA Clone for VCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for VCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for VCAM1 (VCAM-1/CD106)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: |
Expression for VCAM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Cardiomyocytes Myocardium
- Left Ventricle
-
Bone (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
- Bone marrow-derived mesenchymal stem cells (family)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Satellite Cells Sacral Muscle Satellite Pool
- Muscle Satellite Cells Thoracic Muscle Satellite Pool
- Muscle Satellite Cells Cervical Muscle Satellite Pool
- Muscle Satellite Cells Lumbar Muscle Satellite Pool
- Myoblasts Mandibular Arch Muscles
- Brain (Nervous System)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Vesicle
- Parietal epithelial cells (PEC)
- Epithelial Cells
- Placenta (Extraembryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Bone Marrow
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- White adipocyte-like cells(Ahfeldt T et. al. 2012)
-
Testis (Reproductive System)
- Perivascular Cells Testis Interstitium
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
- Pericytes Splanchnic Mesoderm
- Glial Cells
- Blood (Hematopoietic System)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Gonad
- Perivascular Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
- Hair
- Ovary (Reproductive System)
- NULL (Uncategorized)
- Spinal Cord (Nervous System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for VCAM1 Gene
This gene is overexpressed in Spleen (x15.9), Adrenal Gland (x4.2), and Kidney - Cortex (x4.0).
This gene is overexpressed in Serum (45.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VCAM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of VCAM1 Gene:
VCAM1SOURCE GeneReport for Unigene cluster for VCAM1 Gene:
Hs.109225mRNA Expression by UniProt/SwissProt for VCAM1 Gene:
P19320-VCAM1_HUMAN
Tissue specificity:
Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Evidence on tissue expression from TISSUES for VCAM1 Gene
- Heart(4.8)
- Bone marrow(4.6)
- Eye(4.4)
- Spleen(3.7)
- Blood(3.6)
- Kidney(3.4)
- Lung(3.2)
- Lymph node(3.1)
- Liver(3)
- Nervous system(3)
- Muscle(2.9)
- Intestine(2.7)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for VCAM1
-
OriGene qPCR primer pairs for VCAM1
- genomics-online: primer clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCAM1 Gene
Orthologs for VCAM1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VCAM1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | VCAM1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC534578 33 |
|
||
| VCAM1 34 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Vcam1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Vcam1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VCAM1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | VCAM1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VCAM1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VCAM1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | vcam1 33 34 |
|
- Species where no ortholog for VCAM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for VCAM1 Gene
(1) SIMAP similar genes for VCAM1 Gene using alignment to 7 proteins:
Variants for VCAM1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000371179 | -- | 100,724,810(+) | T/A/C | coding_sequence_variant, missense_variant | |
| rs1000903747 | -- | 100,730,707(+) | A/G | intron_variant | |
| rs1001093955 | -- | 100,739,000(+) | G/A | 3_prime_UTR_variant | |
| rs1001199909 | -- | 100,730,806(+) | T/G | intron_variant | |
| rs1001231059 | -- | 100,736,954(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VCAM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAM1 Gene
Disorders for VCAM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral encephalitis |
|
|
| mooren's ulcer |
|
|
| leukostasis |
|
|
| shwartzman phenomenon |
|
|
| arteriosclerosis obliterans |
|
Search VCAM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VCAM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for VCAM1 Gene
Publications for VCAM1 Gene
- Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams GT … Kutlar A (BMC medical genetics 2003) 3 22 44 58
- Alternative splicing of human VCAM-1 in activated vascular endothelium. (PMID: 1707234) Cybulsky MI … Collins T (The American journal of pathology 1991) 3 4 22 58
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
Products for VCAM1 Gene
- R&D Systems Antibodies for VCAM1 (VCAM-1/CD106)
- R&D Systems Proteins and Enzymes for VCAM1 (VCAM-1/CD106)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for VCAM1 (VCAM-1/CD106)
- R&D Systems cDNA Clones for VCAM1 (VCAM-1/CD106)
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for VCAM1
- AM05549PU-N
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- SM1178
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- TA600240
- TA700239
- Custom Assay ServicesOriGene ELISA Kits for VCAM1
- Search Origene for MassSpec and Protein Over-expression Lysates for VCAM1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
- OriGene qPCR primer pairs and template standards for VCAM1
- OriGene qPCR primer pairs for VCAM1
- OriGene CRISPR knockouts for VCAM1
- OriGene ORF clones in human for VCAM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for VCAM1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for VCAM1
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- GenScript: Design CRISPR guide RNA sequences for VCAM1
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for VCAM1
- Sino Biological Recombinant Proteins for VCAM1
- Sino Biological Cell Lysates for VCAM1
- Sino Biological Antibodies for VCAM1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for VCAM1
- Novus Biologicals lysates and proteins for VCAM1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for VCAM1
- Abcam proteins for VCAM1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- ProSpec Recombinant Proteins for VCAM1
- Cloud-Clone Corp. Antibodies for VCAM1
- Cloud-Clone Corp. Proteins for VCAM1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor and PureStem Z11, Meso Progenitor for VCAM1
- Invitrogen Antibodies for VCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 739 available VCAM1 Antibodies ranked by validation data
- Compare Top VCAM1 Antibodies
- Recommended
- 193 WB Antibodies (anti-human)
- 78 FACS Antibodies (anti-human)
- 42 IHC (p) Antibodies (anti-human)
- 33 IP Antibodies (anti-human)
- 15 IHC (fro) Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 LMNX Antibody (anti-human)
- 1 Purif Antibody (anti-human)
- 61 FACS Antibodies (anti-mouse)
- 56 WB Antibodies (anti-mouse)
- 47 IHC Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 13 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 38 WB Antibodies (anti-rat)
- 17 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IF Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Search results for 119 available VCAM1 Elisa Kits ranked by validation data
- Compare Top VCAM1 Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 5 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Hamster ELISA Kit
- 41 Human ELISA Kits
- 3 Monkey ELISA Kits
- 26 Mouse (Murine) ELISA Kits
- 11 Pig (Porcine) ELISA Kits
- 9 Rabbit ELISA Kits
- 15 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 66 available VCAM1 Proteins ranked by validation data
- Compare Top VCAM1 Proteins
- GeneTex VCAM1 antibody for VCAM1
- GeneTex Proteins for VCAM1
- ViGene Biosciences adenoviral particle packaged cDNA for VCAM1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VCAM1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
- Search ViGene Biosciences for VCAM1
- Santa Cruz Biotechnology (SCBT) Antibodies for VCAM1
- Search Santa Cruz Biotechnology (SCBT) for VCAM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- Horizon Cell Lines for VCAM1
- genomics-online: cdna clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- orf clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- genomics-online: gRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- genomics-online: primer clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
- genomics-online: shRNA clones - Search results for 157 available VCAM1 gene related products
- Overview of 157 available VCAM1 gene related products
Sources for VCAM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew