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VCAM1 Gene

protein-coding GIFtS: 69

GC01P100897

vascular cell adhesion molecule 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD106 ^¹, ²
DKFZp779G2333 ^²
INCAM-100 ^², ³
L1CAM ^³
MGC99561 ^²
OTTHUMP00000012650 ^²
OTTHUMP00000012651 ^²

Descriptions
CD106 antigen ^², ³
V-CAM 1 ^³
vascular cell adhesion molecule 1 ^²

External Ids
HGNC: 12663¹
Entrez Gene: 7412²
UniProtKB: P19320³
Ensembl: ENSG00000162692⁷

Search outside databases for aliases for VCAM1 gene

Previous GC identifers: GC01P101976 GC01P100366 GC01P100476 GC01P100648

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VCAM1:

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed

by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial

cell adhesion and signal transduction, and may play a role in the development of artherosclerosis

and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have

been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320

Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell

adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and

signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune

responses and in leukocyte emigration to sites of inflammation

Gene Wiki entry for VCAM1 (VCAM-1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VCAM1 gene

Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p32-p31

VCAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P100897: (about GC identifiers)

Start:	100,957,885 bp from pter
End:	100,977,189 bp from pter
Size:	19,305 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320 (See protein sequence)

Recommended Name: Vascular cell adhesion protein 1 precursor

Size: 739 amino acids; 81276 Da

Subunit: Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1IJ9 (3D)

1VCA (3D)

1VSC (3D)

Secondary accessions: Q6NUP8

Alternative splicing: 2 isoforms: P19320-1 P19320-2 (Additional isoforms seem to exist)

Post-translational modifications:

Sialoglycoprotein¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001069.1 NP_542413.1

ENSEMBL proteins:

ENSP00000294728 ENSP00000304611 ENSP00000359137 ENSP00000359133

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for VCAM1 (VCAM-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VCAM1)
	Human Recombinant Proteins from Abnova (VCAM1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	9290466
GO:0005902	microvillus	IDA	12082081
GO:0009897	external side of plasma membrane	IDA	1377228
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for VCAM1:

	Invitrogen Antibodies for VCAM1
	Millipore Mono- and Polyclonal Antibodies for the study of VCAM1
	Sigma-Aldrich Antibodies for VCAM1
	R&D Systems Antibodies for VCAM1 (VCAM-1)
	Antibodies from Abcam (VCAM1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VCAM1)
	Novus Biologicals Antibodies for VCAM1

Assays for VCAM1:

	Invitrogen Assays for VCAM1
	Millipore Kits and Assays for the Analysis of VCAM1
	R&D Systems ELISAs for VCAM1 (VCAM-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P19320

ProtoNet protein and cluster: P19320

5/6 Blocks protein families (see all 6 ):

IPB003598 Immunoglobulin C-2 type

IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature

IPB003989 Vascular cell adhesion molecule-1 (VCAM-1) signature

IPB008424 T-cell surface antigen CD2

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320

Domain: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell

adhesion

Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCAM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001078

Applied Biosystems Silencer® siRNAs for VCAM1

Sigma-Aldrich siRNA and siRNA Panels for VCAM1

Sigma-Aldrich shRNA Panels and shRNA for VCAM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VCAM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001078
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001078
untagged cDNA clones in CMV expression vector (see all 2): NM_001078

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001078

UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320

Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell

adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and

signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune

responses and in leukocyte emigration to sites of inflammation

Induction: By cytokines (e.g. IL-1, TNF-alpha)

Genatlas biochemistry entry for VCAM1:

cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4

(VLA4A),endothelial sialoglycoprotein

11 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Vcam1):

	embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	muscle	no phenotypic analysis
reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	IDA	1377228
GO:0050839	cell adhesion molecule binding	IPI	12082081

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for VCAM1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Leukocyte Extravasation Signaling
Glucocorticoid Receptor Signaling
HMGB1 Signaling
Lymphotoxin &beta
IL-8 Signaling

GeneDecks VCAM1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for VCAM1

5/135 Interacting proteins for VCAM1 (ENSP00000294728³) via UniProtKB, MINT, and/or STRING (see all 135 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB1	ENSP00000364094³	STRING (score=.999)
ITGA4	ENSP00000233573³	STRING (score=.998)
ITGB7	ENSP00000267082³	STRING (score=.992)
IFNG	ENSP00000229135³	STRING (score=.981)
IL10	ENSP00000356066³	STRING (score=.978)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007157	heterophilic cell adhesion	IDA	1715889
GO:0022614	membrane to membrane docking	IEP	12082081
GO:0030183	B cell differentiation	IC	1715889
GO:0042102	positive regulation of T cell proliferation	IDA	1381355
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VCAM1
10/54 Novoseek chemical compound relationships for VCAM1 gene (see all 54 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	59.73	44	17956026 (4), 12853519 (3), 8879177 (3), 8876553 (3) (see all 29)
gallin	55.24	1	12176755 (1)
slex	50.38	10	12580864 (1), 16689823 (1), 7541055 (1), 18334960 (1) (see all 10)
sele	48.91	5	17367508 (2), 15784173 (2), 18248671 (1)
hematein	47.77	7	11689202 (4), 11243852 (3)
2-hydroxy-4-trifluoromethylbenzoic acid	47.77	2	11159705 (1), 10217529 (1)
12-deoxyphorbol-13-phenylacetate-20-acetate	44.49	4	7686753 (3)
sp 600125	41.05	11	16288471 (3), 17669626 (2), 17303384 (2), 18084318 (1) (see all 7)
nitric oxide	38.06	109	10477680 (6), 9047077 (4), 19000993 (3), 11961404 (3) (see all 55)
pd 98,059	37.44	11	17982268 (1), 15339908 (1), 17241169 (1), 12193740 (1) (see all 10)

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1 PharmGKB drug compound relationship for VCAM1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	12729843

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VCAM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001078

Sigma-Aldrich siRNA and siRNA Panels for VCAM1

Sigma-Aldrich shRNA Panels and shRNA for VCAM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001078 NM_080682

REFSEQ mRNAs for VCAM1 gene (2 alternative transcripts):

NM_001078.2 NM_080682.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001078 NM_080682

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001078
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001078
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001078

Additional cDNA sequence:

AK223266.1 AK291732.1 AK296692.1 BC017276.2 BC068490.1 BC085003.1 CR603251.1 CR617596.1

CR749464.1 M30257.1 M60335.1 X53051.1

8 DOTS entries:

DT.99984904 DT.86847668 DT.95215698 DT.91713724 DT.101980019 DT.121406248 DT.100786305 DT.100786302

24/152 AceView cDNA sequences (see all 152 ):

CA435941 AI913391 BE349086 BP338426 AL553312 BQ707887 BC017276 BF968655

BF590035 AU100302 AU077322 AU108079 AL547454 CR603251 X53051 NM_080682

AI985330 BE326642 CA435946 AI243974 AU280567 M30257 M60335 BE326756

highest scoring ESTs for VCAM1:

M30257 AA033639 AA034346 AA225365 AA225417 AA523734 AA885912 AA969106 AI005203 AI033695

Unigene Cluster for VCAM1:

Vascular cell adhesion molecule 1

Hs.109225 [show with all ESTs]

Unigene Representative Sequence: CR749464

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VCAM1 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:							-
SP2:							-				-
SP3:							-																		-
SP4:							-														-
SP5:					-		-

About this scheme

ECgene alternative splicing isoforms for VCAM1

4 Ensembl transcripts including schematic representations:

ENST00000294728 ENST00000347652 ENST00000370119 ENST00000370115

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VCAM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VCAM1

¹ / ² / ³

4 probe-sets matching VCAM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41433_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.02	M73255	0.20	1.00	0.72	1
583_s_at²^{, 3}	U95-A	2	1.00	0.97	0.99	0.98	M30257	1.00	1.00	1.00	1
203868_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001078	0.60	1.00	0.82	1
203868_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VCAM1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTACGGAGAT

SOURCE GeneReport for Unigene cluster: Hs.109225
Expression variation in blood from EXPOLDB for VCAM1
UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320
Tissue specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and
dendritic cell types in both normal and inflamed tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VCAM1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VCAM1¹	--	vascular cell adhesion molecule 1	84.26(n) 81.06(a)	403982 NM_001003298.1 NP_001003298.1
cow (Bos taurus)	VCAM1¹	--	vascular cell adhesion molecule 1	83.45(n) 77.4(a)	534578 XM_614390.3 XP_614390.2
rat (Rattus norvegicus)	Vcam1¹	--	vascular cell adhesion molecule 1	80.83(n) 76.86(a)	25361 NM_012889.1 NP_037021.1
mouse (Mus musculus)	Vcam1^{1, 5}	3 (50.80 cM)⁵	vascular cell adhesion molecule 1^{1, 5}	80.33(n)¹ 75.78(a)¹	22329¹ NM_011693.2¹ NP_035823.2¹ AK016465⁵ AK078081⁵ (see all 41)
chicken (Gallus gallus)	VCAM1¹	--	vascular cell adhesion molecule 1	55.73(n) 44.53(a)	424467 XM_422310.2 XP_422310.1

About this table Species with no ortholog for VCAM1

ENSEMBL Gene Tree for VCAM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VCAM1 gene

HSPG2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/194 NCBI SNPs in VCAM1 are shown (see all 194 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 135)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1041163^1,2	A,C,F,H,O	100956413(+)	`AATTTT/CTCTGA`	2	--	ng5¹		26	EA NA NS EU WA MN CSAM	3250
	rs1409419^1,2	A,C,F,H	100955984(+)	`ATTAAC/TCAGTA`	2	--	ng5¹ tfbs³		25	EA NA NS EU WA	3134
	rs3783621^1,2	A,C,F,H	100977083(+)	`AGACTC/ACTGTG`	2	--	ut3¹ ese³		15	NA EA NS EU WA	1224
	rs3181093^1,2	A,C,F,H	100977316(+)	`accctC/Tagact`	2	--	ng3¹		13	NA NS EU EA WA	1092
	rs3181092^1,2	C,F,H,O	100977232(+)	`GTCACA/GTTGTA`	2	--	ng3¹		16	NA NS EU EA WA	1236
	rs3783618^1,2	C,F,H	100976714(+)	`CATAGC/AAAGAT`	2	--	ut3¹ ese³		16	NA NS MN CSAM EA EU WA	1190
	rs3783613^1,2	C,F,H	100969375(+)	`GAGTGG/CTGGCC`	2	A/G	mis¹ ese³		27	NA NS MN CSAM EA EU WA	2704
	rs3783612^1,2	C,F,H	100967472(+)	`TGTGCA/GCAGTG`	2	T/A	mis¹ int¹ ese³		13	NA NS MN CSAM EA EU WA	1682
	rs3170794^1,2	C,F,H	100957172(+)	`AAGTAC/TGCAAA`	2	--	ng5¹ tfbs³		16	NA EU EA WA NS	1790
	rs3181087^1,2	C,F,H	100956763(+)	`TTATTA/TTTGCA`	2	--	ng5¹ tfbs³		6	NA EU EA WA	864

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HapMap Linkage Disequilibrium images for VCAM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 192225

UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320

May play an important role in the genesis of atherosclerosis and rheumatoid arthritis

10/98 Novoseek disease relationships for VCAM1 gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	79.32	194	9316879 (2), 16327982 (2), 9627176 (2), 18225982 (2) (see all 99)
atherosclerosis	77.31	113	9102169 (4), 12601631 (3), 17000904 (2), 10715810 (2) (see all 87)
necrosis	77.21	307	12174154 (3), 9396925 (3), 12707049 (2), 7499419 (2) (see all 99)
tumors	59.98	417	12854131 (6), 17189405 (4), 18931829 (4), 18211818 (4) (see all 99)
atherosclerotic plaque	56.64	19	7541294 (2), 8640995 (2), 7551271 (1), 10341839 (1) (see all 17)
rheumatoid arthritis	47.72	21	7531793 (1), 9133922 (1), 10817566 (1), 15700117 (1) (see all 20)
vascular diseases	47.42	15	19252763 (3), 14506626 (1), 8616048 (1), 10735600 (1) (see all 11)
preeclampsia	45.23	66	9856316 (4), 10759271 (4), 17083832 (3), 16202929 (3) (see all 26)
cardiovascular diseases	44.03	16	11726042 (2), 17148932 (2), 18225982 (2), 18504269 (1) (see all 12)
renal vasculitis	42.17	6	8546138 (2), 9490207 (1), 9572400 (1), 9441008 (1)

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Human Gene Mutation Database: VCAM1
Genetic Association Database: VCAM1
Human Genome Epidemiology Navigator: VCAM1 (30 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1893 PubMed articles for VCAM1 gene (see all 1893 ):

Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)^{1, 3, 6} Adams G.T....Kutlar A. (2003)
Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. (PubMed id 12393616)^{1, 3, 6} Taylor J.G....Chanock S.J. (2002)
Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution. (PubMed id 7531291)^{1, 3, 4} Jones E.Y.... Stuart D.I. (1995)
Alternative splicing of human VCAM-1 in activated vascular endothelium. (PubMed id 1707234)^{1, 3, 4} Cybulsky M.I.... Collins T. (1991)
Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. (PubMed id 1715583)^{1, 3, 4} Cybulsky M.I.... Collins T. (1991)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. (PubMed id 16230423)^{3, 6} Lan Q....Rothman N. (2005)
Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician's Health Study. (PubMed id 16184405)^{3, 6} Rosner S.A....Cook N.R. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7412	HGNC: 12663	AceView: VCAM1	Ensembl:ENSG00000162692	euGenes: HUgn7412
ECgene: VCAM1	H-InvDB: VCAM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for VCAM1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/VCAM1
SeattleSNPs	http://pga.gs.washington.edu/data/vcam1/
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_266

Licensable Technologies for VCAM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VCAM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VCAM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VCAM1		Antibodies for VCAM1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VCAM1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VCAM1)
	Antibodies (VCAM1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (VCAM1)
	Antibodies (VCAM1)

Search OriGene for VCAM1

Search Tocris compounds for VCAM1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VCAM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VCAM1 Gene at Home site.
Version 2.41.1
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VCAM1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for VCAM1

Summaries
for VCAM1

Genomic Location
for VCAM1

Proteins
for VCAM1

Protein Domains/
Families
for VCAM1

Gene Function
for VCAM1

Pathways & Interactions
for VCAM1

Drugs & Compounds
for VCAM1

Transcripts
for VCAM1

Expression
for VCAM1

Orthologs
for VCAM1

Paralogs
for VCAM1

SNPs/Variants
for VCAM1

Disorders & Mutations
for VCAM1

Medical News
for VCAM1

Publications
for VCAM1

Search for VCAM1

Genome Databases showing VCAM1

Other Databases showing VCAM1

Specialized Databases showing VCAM1

Licensable Technologies
for VCAM1

Services
for VCAM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VCAM1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor VCAM1

Summariesfor VCAM1

Genomic Locationfor VCAM1

Proteinsfor VCAM1

Protein Domains/Familiesfor VCAM1

Gene Functionfor VCAM1

Pathways & Interactionsfor VCAM1

Drugs & Compoundsfor VCAM1

Transcriptsfor VCAM1

Expression for VCAM1

Orthologsfor VCAM1

Paralogsfor VCAM1

SNPs/Variantsfor VCAM1

Disorders & Mutationsfor VCAM1

Medical Newsfor VCAM1

Publicationsfor VCAM1

Search for VCAM1

Genome Databases showing VCAM1

Other Databases showing VCAM1

Specialized Databases showing VCAM1

Licensable Technologiesfor VCAM1

Servicesfor VCAM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VCAM1

Summaries
for VCAM1

Genomic Location
for VCAM1

Proteins
for VCAM1

Protein Domains/
Families
for VCAM1

Gene Function
for VCAM1

Pathways & Interactions
for VCAM1

Drugs & Compounds
for VCAM1

Transcripts
for VCAM1

Expression
for VCAM1

Orthologs
for VCAM1

Paralogs
for VCAM1

SNPs/Variants
for VCAM1

Disorders & Mutations
for VCAM1

Medical News
for VCAM1

Publications
for VCAM1

Licensable Technologies
for VCAM1

Services
for VCAM1