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VCAM1 Gene

protein-coding   GIFtS: 70
GCID: GC01P101185

Vascular Cell Adhesion Molecule 1

  See VCAM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vascular Cell Adhesion Molecule 11 2     Vascular Cell Adhesion Protein 12
INCAM-1002 3     L1CAM3
CD106 Antigen2 3     VCAM-13
CD1062     V-CAM 13

External Ids:    HGNC: 126631   Entrez Gene: 74122   Ensembl: ENSG000001626927   OMIM: 1922255   UniProtKB: P193203   

Export aliases for VCAM1 gene to outside databases

Previous GC identifers: GC01P101976 GC01P100366 GC01P100476 GC01P100648 GC01P100897 GC01P099309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VCAM1 Gene:
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by
cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and
signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three
alternatively spliced transcripts encoding different isoforms have been described for this gene. (provided by
RefSeq, Dec 2010)

GeneCards Summary for VCAM1 Gene:
VCAM1 (vascular cell adhesion molecule 1) is a protein-coding gene. Diseases associated with VCAM1 include mooren's ulcer, and vasculitis. GO annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is SIGLEC1.

UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion.
Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal
transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in
leukocyte emigration to sites of inflammation

Gene Wiki entry for VCAM1 (VCAM-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the VCAM1 gene promoter:
         CREB   STAT1   deltaCREB   PPAR-gamma2   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVCAM1 promoter sequence
   Search Chromatin IP Primers for VCAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VCAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p32-p31

VCAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VCAM1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P101185:  view genomic region     (about GC identifiers)

Start:
101,185,196 bp from pter      End:
101,204,601 bp from pter
Size:
19,406 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320 (See protein sequence)
Recommended Name: Vascular cell adhesion protein 1 precursor  
Size: 739 amino acids; 81276 Da
Subunit: Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity)
3 PDB 3D structures from and Proteopedia for VCAM1:
1IJ9 (3D)        1VCA (3D)        1VSC (3D)    
Secondary accessions: A8K6R7 B4DKS4 E9PDD1 Q6NUP8
Alternative splicing: 3 isoforms:  P19320-1   P19320-2   P19320-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VCAM1: NX_P19320

Explore proteomics data for VCAM1 at MOPED

Post-translational modifications: 

  • Sialoglycoprotein1
  • Glycosylation2 at Asn273, Asn365, Asn417, Asn463, Asn531, Asn561
  • Modification sites at PhosphoSitePlus

  • See VCAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001069.1  NP_001186763.1  NP_542413.1  

    ENSEMBL proteins: 
     ENSP00000359137   ENSP00000304611   ENSP00000294728   ENSP00000359133  
    Reactome Protein details: P19320

    VCAM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for VCAM1 (VCAM-1/CD106)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for VCAM1
    OriGene Protein Over-expression Lysate for VCAM1
    OriGene MassSpec for VCAM1
    OriGene Custom Protein Services for VCAM1
    GenScript Custom Purified and Recombinant Proteins Services for VCAM1
    Novus Biologicals VCAM1 Proteins
    Novus Biologicals VCAM1 Lysates
    Sino Biological Recombinant Protein for VCAM1
    Sino Biological Cell Lysate for VCAM1
    ProSpec Recombinant Protein for VCAM1
    Cloud-Clone Corp. Proteins for VCAM1

     
    Search eBioscience for Proteins for VCAM1 

     
    antibodies-online proteins for VCAM1 (54 products) 

     
    antibodies-online peptides for VCAM1

    VCAM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VCAM1
    R&D Systems Antibodies for VCAM1 (VCAM-1/CD106)
    Cell Signaling Technology (CST) Antibodies for VCAM1 
    OriGene Antibodies for VCAM1
    OriGene Custom Antibody Services for VCAM1
    Novus Biologicals VCAM1 Antibodies
    Abcam antibodies for VCAM1
    Cloud-Clone Corp. Antibodies for VCAM1
    ThermoFisher Antibody for VCAM1
    antibodies-online antibodies for VCAM1 (354 products) 

    VCAM1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of VCAM1
    OriGene Custom Assay Services for VCAM1
    R&D Systems ELISAs for VCAM1 (VCAM-1/CD106)         (see all)
    GenScript Custom Assay Services for VCAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VCAM1
    Cloud-Clone Corp. CLIAs for VCAM1
    eBioscience ELISAs for VCAM1: (see all 2
                        Human sVCAM-1 Platinum ELISA 96 tests
    antibodies-online kits for VCAM1 (76 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    ENDOLIG: Endogenous ligands
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR008424 Ig_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P19320

    ProtoNet protein and cluster: P19320

    Selected Blocks protein domains (see all 6):
    IPB003598 Immunoglobulin C-2 type
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003989 Vascular cell adhesion molecule-1 (VCAM-1) signature
    IPB008424 T-cell surface antigen CD2
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320
    Domain: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with VCAM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VCAM1_HUMAN, P19320
    Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion.
    Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal
    transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in
    leukocyte emigration to sites of inflammation
    Induction: By cytokines (e.g. IL-1, TNF-alpha)

         Genatlas biochemistry entry for VCAM1:
    cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial
    sialoglycoprotein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IMP19738201
    GO:0005515protein binding ----
    GO:0008131primary amine oxidase activity IDA--
    GO:0050839cell adhesion molecule binding IPI12082081
         
    Find genes that share ontologies with VCAM1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Vcam1):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with VCAM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VCAM1: Vcam1tm1Roml Vcam1tm3Flv Vcam1tm2Cyb Vcam1tm2.1Roml

       genOway: Develop your customized and physiologically relevant rodent model for VCAM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target VCAM1:
    hsa-mir-200a-3p (MIRT004007), hsa-mir-155-5p (MIRT020917), hsa-mir-126-3p (MIRT004081)

    Block miRNA regulation of human, mouse, rat VCAM1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate VCAM1:
    hsa-miR-1178 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidVCAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VCAM1
    Predesigned siRNA for gene silencing in human, mouse, rat VCAM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VCAM1

    Clone
    Products:
         
    OriGene clones in human, mouse for VCAM1 (see all 11)
    OriGene ORF clones in mouse, rat for VCAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): VCAM1 (NM_080682)
    Sino Biological Human cDNA Clone for VCAM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VCAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCAM1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VCAM1
    ESI BIO PureStem Progenitors for VCAM1: 
    PureStem ES-209, Meso-prx/latp Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VCAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VCAM1_HUMAN, P19320: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    extracellular4
    plasma membrane4
    nucleus3
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA15220135
    GO:0005615extracellular space IDA9290466
    GO:0005769early endosome IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with VCAM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VCAM1 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Paxillin-dependent events mediated by a4b1
    Paxillin-dependent events mediated by a4b10.58
    Paxillin-independent events mediated by a4b1 and a4b70.58
    3Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    4p70S6K Signaling
    Renin-Angiotensin Pathway0.60
    5LT-BetaR Pathway
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46


    Find genes that share SuperPaths with VCAM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for VCAM1
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VCAM1
        Renin-Angiotensin Pathway
    LDL Oxidation in Atherogenesis
    Transendothelial Migration of Leukocytes

    2 Cell Signaling Technology (CST) Pathways for VCAM1
        Lymphocyte Signaling
    Adhesion

    4 GeneGo (Thomson Reuters) Pathways for VCAM1
        Immune response MIF-mediated glucocorticoid regulation
    Development VEGF signaling and activation
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Immune response Role of integrins in NK cells cytotoxicity

    5 BioSystems Pathways for VCAM1
        RANKL/RANK Signaling Pathway
    Paxillin-independent events mediated by a4b1 and a4b7
    Paxillin-dependent events mediated by a4b1
    Cellular roles of Anthrax toxin
    Thromboxane A2 receptor signaling


    3 Reactome Pathways for VCAM1
        Integrin cell surface interactions
    Interferon gamma signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for VCAM1) (see all 7):
        NF-kappa B signaling pathway
    Cell adhesion molecules (CAMs)
    TNF signaling pathway
    Leukocyte transendothelial migration
    African trypanosomiasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VCAM1 (see all 11): 
              Osteogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VCAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VCAM1 (P193203 ENSP000002947284) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL17Q925833, ENSP000002192444I2D: score=4 STRING: ENSP00000219244
    ITGB7P260103, ENSP000002670824I2D: score=2 STRING: ENSP00000267082
    IL13P352253, ENSP000003049154I2D: score=1 STRING: ENSP00000304915
    ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
    MSNP260383, ENSP000003534084I2D: score=4 STRING: ENSP00000353408
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0002526acute inflammatory response IEA--
    GO:0002544chronic inflammatory response IEA--
    GO:0007155cell adhesion IDA16809613
    GO:0007157heterophilic cell-cell adhesion IDA1715889

    Find genes that share ontologies with VCAM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VCAM1

    1 DrugBank Compound for VCAM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carvedilol-- 72956-09-3targetinhibitor17139284 15374848 17016423

    Selected Novoseek inferred chemical compound relationships for VCAM1 gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 59.7 47 17956026 (4), 12853519 (3), 8879177 (3), 8876553 (3) (see all 32)
    sele 59.5 6 17367508 (2), 15784173 (2), 18248671 (1), 19521071 (1)
    gallin 53.3 1 12176755 (1)
    pdtc 52.3 24 7522548 (4), 10329958 (2), 10430178 (2), 15805138 (2) (see all 12)
    slex 51.1 17 12580864 (1), 16689823 (1), 7541055 (1), 18334960 (1) (see all 11)
    vegf 48.6 114 18554449 (7), 11192830 (6), 18834676 (6), 11108718 (4) (see all 58)
    helenalin 47.9 11 16288471 (3), 17669626 (2), 17303384 (2), 20039412 (2) (see all 5)
    fenofibrate 47.1 8 10377075 (2), 16115476 (1), 17483155 (1), 19531154 (1) (see all 5)
    ro 31-7549 47 1 7686753 (1)
    2-hydroxy-4-trifluoromethylbenzoic acid 45.6 2 11159705 (1), 10217529 (1)



    Find genes that share compounds with VCAM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VCAM1 gene (3 alternative transcripts): 
    NM_001078.3  NM_001199834.1  NM_080682.2  

    Unigene Cluster for VCAM1:

    Vascular cell adhesion molecule 1
    Hs.109225  [show with all ESTs]
    Unigene Representative Sequence: NM_001078
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370119 ENST00000347652(uc001dtj.3) ENST00000294728(uc010ouj.2 uc001dti.3)
    ENST00000370115 ENST00000603679
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate VCAM1:
    hsa-miR-1178 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidVCAM1 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): VCAM1 (NM_080682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VCAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VCAM1
    Primer
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    OriGene qPCR primer pairs and template standards for VCAM1
    OriGene qSTAR qPCR primer pairs in human, mouse for VCAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VCAM1
      QuantiTect SYBR Green Assays in human, mouse, rat VCAM1
      QuantiFast Probe-based Assays in human, mouse, rat VCAM1

    Additional mRNA sequence: 

    AK223266.1 AK291732.1 AK296692.1 BC017276.2 BC068490.1 BC085003.1 M30257.1 M60335.1 
    X53051.1 

    8 DOTS entries:

    DT.99984904  DT.86847668  DT.95215698  DT.101980019  DT.121406248  DT.100786305  DT.100786302  DT.91713724 

    Selected AceView cDNA sequences (see all 152):

    BE326642 AL553312 BU581406 AI985330 CA435946 AL547454 BE349086 AU280567 
    CA435941 BF590035 M60335 BQ707887 AU100302 BC017276 NM_001078 AU077322 
    BC068490 CR617596 AI913391 BE326756 CD251652 BP338426 CR603251 AU108079 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VCAM1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                    -                                                                           
    SP2:                    -           -                                                               
    SP3:                    -                                                     -                     
    SP4:                    -                                         -                                 
    SP5:              -     -                                                                           


    ECgene alternative splicing isoforms for VCAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VCAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACGGAGAT
    VCAM1 Expression
    About this image


    VCAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Placenta-derived mesenchymal stem cells
     
     Heart (Cardiovascular System)    fully expand to see all 11 entries
             Epicardial Progenitors Cells Epicardium
             Interventricular Septum
             Human cardiac stem cells
             Cardiomyocyte-like progenitor cells
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Bone Marrow Stromal Cells Bone Marrow
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             Muscle Satellite Cells Lumbar Muscle Satellite Pool
    VCAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VCAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109225

    UniProtKB/Swiss-Prot: VCAM1_HUMAN, P19320
    Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell
    types in both normal and inflammed tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VCAM1 (see all 11): 
              Osteogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VCAM1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vcam11 , 5 vascular cell adhesion molecule 11, 5 80.29(n)1
    75.78(a)1
      3 (50.17 cM)5
    223291  NM_011693.31  NP_035823.31 
     1161100205 
    chicken
    (Gallus gallus)
    Aves VCAM16
    vascular cell adhesion molecule 1
    35(a)
    1 ↔ 1
    8(10818883-10826594)
    lizard
    (Anolis carolinensis)
    Reptilia VCAM16
    vascular cell adhesion molecule 1
    39(a)
    1 ↔ 1
    4(87675652-87686406)
    zebrafish
    (Danio rerio)
    Actinopterygii vcam11 vascular cell adhesion molecule 1 44.53(n)
    27.83(a)
      561971  NM_001083835.1  NP_001077304.1 


    ENSEMBL Gene Tree for VCAM1 (if available)
    TreeFam Gene Tree for VCAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VCAM1 gene
    SIGLEC12  CD222  
    1 SIMAP similar gene for VCAM1 using alignment to 7 protein entries:     VCAM1_HUMAN (see all proteins):
    DKFZp779G2333

    Find genes that share paralogs with VCAM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VCAM1 (see all 503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39170251,2
    C,F--101183470(+) ATCCT-/CTCAACC 3 -- us2k1 tfbs37Minor allele frequency- CT:0.19NS MN 496
    rs681646841,2
    C--101194965(+) TTTTTT/-CAGTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs39170171,2
    C--101201841(+) CCCAAA/-CTGAA 3 -- int12Minor allele frequency- -:0.01NS 88
    rs113021301,2
    C--101205071(+) TTTTTT/-GAGAC 3 -- ds50011Minor allele frequency- -:0.50NA 2
    rs725508181,2
    C,F--101206744(+) TGATCA/TTTCAT 3 -- us2k15Minor allele frequency- T:0.01MN 396
    rs37835951,2
    C,F,H--101206810(+) AATGAA/CACCAT 3 -- us2k112Minor allele frequency- C:0.09NA NS MN EA 980
    rs14094191,2
    C,F,A,H--101206851(+) ATTAAC/TCAGTA 3 -- us2k1 tfbs348Minor allele frequency- A:0.01EA NA NS MN WA CSA 4728
    rs39170241,2
    C,F--101206909(+) GCCACC/TGAGGA 3 -- us2k111Minor allele frequency- T:0.03NS NA MN WA 734
    rs1485612981,2
    --101206910(+) CCACCA/GAGGAG 3 -- us2k10--------
    rs1429727361,2
    --101207000(+) CAAACA/GTTTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for VCAM1 (101185196 - 101204601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for VCAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871445CNV Loss21882294
    nsv522064CNV Gain19592680

    Human Gene Mutation Database (HGMD): VCAM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VCAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for VCAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192225    OMIM disorders: --

    Selected diseases for VCAM1 (see all 32):    
    About MalaCards
    mooren's ulcer    vasculitis    acute chest syndrome    arteriosclerosis obliterans
    rheumatoid vasculitis    chronic venous insufficiency    mild pre-eclampsia    venous insufficiency
    leukostasis    adult dermatomyositis    dengue disease    lymphocytic vasculitis
    arteriosclerosis    eclampsia    myositis    thromboangiitis obliterans
    severe pre-eclampsia    keshan disease    limbal stem cell deficiency    pre-eclampsia

    15 diseases from the University of Copenhagen DISEASES database for VCAM1:
    Atherosclerosis     Diabetes mellitus     Asthma     Heart disease
    Hypertension     Hypersensitivity reaction type II disease     Rheumatoid arthritis     Vasculitis
    Cancer     Kidney disease     Connective tissue disease     Multiple sclerosis
    Eosinophilia     Dermatitis     Cerebrovascular accident

    Find genes that share disorders with VCAM1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VCAM1 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 80 205 9316879 (2), 16327982 (2), 19771922 (2), 9627176 (2) (see all 99)
    atherosclerosis 78.6 120 9102169 (4), 12601631 (3), 17000904 (2), 10715810 (2) (see all 93)
    necrosis 77.2 317 12174154 (3), 9396925 (3), 12707049 (2), 7499419 (2) (see all 99)
    tumors 60.9 433 12854131 (6), 17189405 (4), 18931829 (4), 18211818 (4) (see all 99)
    atherosclerotic plaque 57.3 23 20075743 (2), 7541294 (2), 19833312 (2), 8640995 (2) (see all 19)
    rheumatoid arthritis 49.7 23 7531793 (1), 9133922 (1), 10817566 (1), 15700117 (1) (see all 22)
    vascular diseases 49.5 16 19252763 (3), 14506626 (1), 20129688 (1), 8616048 (1) (see all 12)
    cardiovascular diseases 46.6 19 11726042 (2), 17148932 (2), 18225982 (2), 18504269 (1) (see all 15)
    shwartzman reaction 46 1 12488365 (1)
    preeclampsia 44.9 66 9856316 (4), 10759271 (4), 17083832 (3), 16202929 (3) (see all 26)

    Genetic Association Database (GAD): VCAM1
    Human Genome Epidemiology (HuGE) Navigator: VCAM1 (65 documents)

    Export disorders for VCAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VCAM1 gene, integrated from 10 sources (see all 2252):
    (articles sorted by number of sources associating them with VCAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA). (PubMed id 18420209)1, 4, 9 Bielinski S.J....Arnett D. (Atherosclerosis 2008)
    2. Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity. Association with genetic polymorphisms. (PubMed id 19597294)1, 4, 9 Navarro-HernA!ndez R.E....MuA+oz-Valle J.F. (Dis. Markers 2009)
    3. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)1, 4, 9 Adams G.T....Kutlar A. (BMC Med. Genet. 2003)
    4. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. (PubMed id 12393616)1, 4, 9 Taylor J.G....Chanock S.J. (Blood 2002)
    5. Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution. (PubMed id 7531291)1, 2, 9 Jones E.Y.... Stuart D.I. (Nature 1995)
    6. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. (PubMed id 1715583)1, 2, 9 Cybulsky M.I.... Collins T. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Alternative splicing of human VCAM-1 in activated vascular endothelium. (PubMed id 1707234)1, 2, 9 Cybulsky M.I.... Collins T. (Am. J. Pathol. 1991)
    8. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    9. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (Diabet. Med. 2010)
    10. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7412 HGNC: 12663 AceView: VCAM1 Ensembl:ENSG00000162692 euGenes: HUgn7412
    ECgene: VCAM1 Kegg: 7412 H-InvDB: VCAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VCAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VCAM1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/VCAM1
    SeattleSNPshttp://pga.gs.washington.edu/data/vcam1/
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_266

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VCAM1 gene:
    Search GeneIP for patents involving VCAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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