Aliases for VCAM1 Gene
Aliases for VCAM1 Gene
External Ids for VCAM1 Gene
- HGNC: 12663
- Entrez Gene: 7412
- Ensembl: ENSG00000162692
- OMIM: 192225
- UniProtKB: P19320
Previous GeneCards Identifiers for VCAM1 Gene
- GC01P101976
- GC01P100366
- GC01P100476
- GC01P100648
- GC01P100897
- GC01P101185
- GC01P099309
Summaries for VCAM1 Gene
-
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for VCAM1 Gene
VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include Mooren's Ulcer and Viral Encephalitis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and LDL Oxidation in Atherogenesis. GO annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is SIGLEC1.
UniProtKB/Swiss-Prot for VCAM1 Gene
-
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAM1 Gene
Genomics for VCAM1 Gene
Regulatory Elements for VCAM1 Gene
Enhancers for VCAM1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G100621 | 1.3 | Ensembl ENCODE dbSUPER | 29.4 | -96.1 | -96087 | 4.4 | PKNOX1 JUN SIN3A FEZF1 CEBPG ZIC2 ZBTB40 FOSL1 ZFHX2 GLIS2 | VCAM1 GPR88 LINC01349 RTCA RPL7AP17 |
| GH01G100712 | 1.3 | Ensembl ENCODE dbSUPER | 21.2 | -6.3 | -6276 | 1.5 | HDGF PKNOX1 BMI1 CBX5 ETV6 RELB CREM IKZF2 CBFB JUNB | VCAM1 PIR61471 |
| GH01G100721 | 0.9 | ENCODE dbSUPER | 21.5 | +2.2 | 2193 | 1.2 | ZNF366 CEBPA ZNF512 CEBPB FOXP2 FOS CEBPG RAD21 | VCAM1 ENSG00000228086 GPR88 GC01P100735 |
| GH01G100626 | 1.2 | Ensembl ENCODE dbSUPER | 11.1 | -90.5 | -90518 | 5.8 | HDAC1 NR2F1 JUNB CEBPG ZFHX2 JUND GATA2 EED IKZF1 TCF7 | VCAM1 LINC01349 RPL7AP17 |
| GH01G100785 | 1.2 | Ensembl ENCODE | 10.5 | +66.2 | 66245 | 1.3 | ATF1 TCF12 ZNF766 CBX5 GATA2 CEBPZ NCOA1 ZNF592 MEF2D MBD2 | TRMT13 HNRNPA1P68 VCAM1 GPR88 BRI3P1 SASS6 SLC30A7 GC01M100814 GC01P100735 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around VCAM1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the VCAM1 gene promoter:
Regulatory Element Products
Genomic Location for VCAM1 Gene
- Chromosome:
- 1
- Start:
- 100,719,640 bp from pter
- End:
- 100,739,045 bp from pter
- Size:
- 19,406 bases
- Orientation:
- Plus strand
Genomic View for VCAM1 Gene
Genes around VCAM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.2 by Ensembl
- 1p21.2 by Entrez Gene
- 1p21.2 by HGNC
VCAM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCAM1 Gene
Proteins for VCAM1 Gene
-
Protein details for VCAM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19320-VCAM1_HUMAN
- Recommended name:
- Vascular cell adhesion protein 1
- Protein Accession:
- P19320
- A8K6R7
- B4DKS4
- E9PDD1
- Q6NUP8
Protein attributes for VCAM1 Gene
- Size:
- 739 amino acids
- Molecular mass:
- 81276 Da
- Quaternary structure:
-
- Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
Protein Expression for VCAM1 Gene
Post-translational modifications for VCAM1 Gene
- Sialoglycoprotein.
- Glycosylation at posLast=273273, posLast=365365, Asn417, isoforms=2, 3463, isoforms=2, 3531, and Asn561
- Modification sites at PhosphoSitePlus
Other Protein References for VCAM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for VCAM1
- R&D Systems Antibodies for VCAM1 (VCAM-1/CD106)
-
Custom Antibody ServicesOriGene Antibodies for VCAM1
- AM05549PU-N
- AM05549PU-T
- AM05549RP-N
- AM06443SU-N
- AM26158BT-N
- TA700239
- TA600240
- TA600239
- TA590416
- TA590415
- TA590414
- TA590413
- CF502426
- TA502426
- CF502411
- TA502411
- CF502392
- TA502392
- CF502391
- TA502391
- CF502390
- TA502390
- CF502361
- TA502361
- CF502360
- TA502360
- TA352567
- TA350599
- TA336775
- TA328469
- TA328468
- TA326818
- TA320511
- TA320510
- SM178PT
- SM1178P
- SM1178FT
- SM1178F
- SM1178
- BM2547
- AP50835PU-N
- AP32710PU-N
- AP22317PU-S
- AP22317PU-N
- AP22317BT-S
- AP22317BT-N
- AM33117PU-T
- AM33117PU-S
- AM33117PU-N
- AM33018PU-N
- AM31329BT-N
- AM31306AF-N
- AM31190PU-N
- AM31190AF-N
- AM26718PU-N
- AM26158PU-N
- Novus Biologicals Antibodies for VCAM1
-
Cloud-Clone Corp. Antibodies for VCAM1
- Invitrogen Antibodies for VCAM1
- antibodies-online Antibodies for VCAM1: See all 625
- GeneTex VCAM1 antibody for VCAM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for VCAM1
Protein Products
- R&D Systems Proteins and Enzymes for VCAM1 (VCAM-1/CD106)
- Search Origene for MassSpec and Protein Over-expression Lysates for VCAM1
- Origene Custom Protein Services for VCAM1
- Sino Biological Recombinant Proteins for VCAM1
- Sino Biological Cell Lysates for VCAM1
- ProSpec Recombinant Proteins for VCAM1
-
Cloud-Clone Corp. Proteins for VCAM1
- antibodies-online Proteins for VCAM1: See all 74
- Search antibodies-online for peptides
- GeneTex Proteins for VCAM1
Assay Products
- EMD Millipore Kits and Assays for VCAM1
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for VCAM1 (VCAM-1/CD106)
- eBioscience Human sVCAM-1 Platinum ELISA 96 tests and Human sVCAM-1 Platinum ELISA 96 tests for VCAM1
- antibodies-online Kits for VCAM1: See all 120
No data available for DME Specific Peptides for VCAM1 Gene
Domains & Families for VCAM1 Gene
Gene Families for VCAM1 Gene
Protein Domains for VCAM1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VCAM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P19320UniProtKB/Swiss-Prot:
VCAM1_HUMAN :- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
- Domain:
-
- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Function for VCAM1 Gene
Molecular function for VCAM1 Gene
- GENATLAS Biochemistry:
- cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial sialoglycoprotein
- UniProtKB/Swiss-Prot Function:
- Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
- UniProtKB/Swiss-Prot Induction:
- By cytokines (e.g. IL-1, TNF-alpha).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005178 | integrin binding | IMP | 19738201 |
| GO:0008131 | primary amine oxidase activity | IDA | 23474851 |
| GO:0050839 | cell adhesion molecule binding | IPI | 12082081 |
Phenotypes for VCAM1 Gene
- MGI mutant phenotypes for VCAM1:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for VCAM1:
Animal Models for VCAM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VCAM1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
- Search ViGene Biosciences for VCAM1
CRISPR Products
-
OriGene CRISPR knockouts for VCAM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- GenScript: Design CRISPR guide RNA sequences for VCAM1
miRNA for VCAM1 Gene
- miRTarBase miRNAs that target VCAM1
-
- hsa-mir-200a-3p (MIRT004007)
- hsa-mir-126-3p (MIRT004081)
- hsa-mir-155-5p (MIRT020917)
- bta-mir-145 (MIRT053908)
- bta-mir-181a (MIRT053974)
- hsa-mir-23c (MIRT504350)
- hsa-mir-23b-3p (MIRT504351)
- hsa-mir-23a-3p (MIRT504352)
- hsa-mir-130a-5p (MIRT504353)
- hsa-mir-190a-3p (MIRT504354)
- hsa-mir-6074 (MIRT504355)
- hsa-mir-5011-5p (MIRT504356)
- hsa-mir-1277-5p (MIRT504357)
- hsa-mir-6516-5p (MIRT533248)
- hsa-mir-4677-5p (MIRT533249)
- hsa-mir-3678-3p (MIRT533250)
- hsa-mir-1273h-3p (MIRT533251)
- hsa-mir-6844 (MIRT533252)
- hsa-mir-22-5p (MIRT533253)
- hsa-mir-2116-5p (MIRT533254)
- hsa-mir-2467-3p (MIRT533255)
- hsa-mir-96-3p (MIRT533256)
- hsa-mir-5694 (MIRT533257)
- hsa-mir-6856-3p (MIRT533258)
- hsa-mir-186-5p (MIRT533259)
- hsa-mir-5092 (MIRT610905)
- hsa-mir-519d-5p (MIRT619598)
- hsa-mir-3145-5p (MIRT619599)
- hsa-mir-548x-3p (MIRT635473)
- hsa-mir-548j-3p (MIRT635474)
- hsa-mir-548aq-3p (MIRT635475)
- hsa-mir-548am-3p (MIRT635476)
- hsa-mir-548aj-3p (MIRT635477)
- hsa-mir-548ah-3p (MIRT635478)
- hsa-mir-548ae-3p (MIRT635479)
- hsa-mir-7110-3p (MIRT707380)
- hsa-mir-6845-3p (MIRT707381)
- hsa-mir-136-5p (MIRT707382)
- hsa-mir-6769b-3p (MIRT707383)
- hsa-mir-4723-3p (MIRT707384)
- hsa-mir-3183 (MIRT707385)
- hsa-mir-3127-5p (MIRT715352)
- hsa-mir-3691-3p (MIRT715353)
- hsa-mir-6754-5p (MIRT715354)
- hsa-mir-4441 (MIRT715355)
- hsa-mir-4270 (MIRT715356)
- hsa-mir-211-3p (MIRT715357)
- hsa-mir-506-5p (MIRT715358)
- hsa-mir-181b-5p (MIRT715359)
- hsa-mir-4262 (MIRT715360)
- hsa-mir-181d-5p (MIRT715361)
- hsa-mir-181c-5p (MIRT715362)
- hsa-mir-181a-5p (MIRT715363)
miRNA Products
- Search ViGene Biosciences for VCAM1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
Clone Products
- Sino Biological Human cDNA Clone for VCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for VCAM1 (VCAM-1/CD106)
Cell Line Products
- ESI BIO PureStem Z11, Meso Progenitor and PureStem ES-209, Meso-prx/latp Progenitor for VCAM1
-
Horizon Cell Lines for VCAM1
-
ViGene Biosciences adenoviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VCAM1 Gene
Localization for VCAM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCAM1 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002102 | podosome | IDA | 15220135 |
| GO:0005615 | extracellular space | IDA | 9290466 |
| GO:0005769 | early endosome | IDA | 23474851 |
| GO:0005783 | endoplasmic reticulum | IDA | 23474851 |
| GO:0005794 | Golgi apparatus | IDA | 23474851 |
Pathways & Interactions for VCAM1 Gene
Pathways by source for VCAM1 Gene
2 Cell Signaling Technology pathways for VCAM1 Gene
7 BioSystems pathways for VCAM1 Gene
10 Reactome pathways for VCAM1 Gene
4 GeneGo (Thomson Reuters) pathways for VCAM1 Gene
6 R&D Systems pathways for VCAM1 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- IgA-Producing B Cells in the Intestine
- IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
3 Qiagen pathways for VCAM1 Gene
Interacting Proteins for VCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0002526 | acute inflammatory response | IEA | -- |
| GO:0002544 | chronic inflammatory response | IEA | -- |
| GO:0007155 | cell adhesion | IDA,IEA | 16809613 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IDA | 1715889 |
No data available for SIGNOR curated interactions for VCAM1 Gene
Transcripts for VCAM1 Gene
mRNA/cDNA for VCAM1 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (152) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VCAM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VCAM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- GenScript: Design CRISPR guide RNA sequences for VCAM1
miRNA Products
- Search ViGene Biosciences for VCAM1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAM1 gene
Clone Products
- Sino Biological Human cDNA Clone for VCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for VCAM1 (VCAM-1/CD106)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: |
Expression for VCAM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Cardiomyocytes Myocardium
- Left Ventricle
-
Bone (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
- Bone marrow-derived mesenchymal stem cells (family)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Satellite Cells Sacral Muscle Satellite Pool
- Muscle Satellite Cells Thoracic Muscle Satellite Pool
- Muscle Satellite Cells Cervical Muscle Satellite Pool
- Muscle Satellite Cells Lumbar Muscle Satellite Pool
- Myoblasts Mandibular Arch Muscles
- Brain (Nervous System)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Vesicle
- Parietal epithelial cells (PEC)
- Epithelial Cells
- Placenta (Extraembryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Bone Marrow
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- White adipocyte-like cells(Ahfeldt T et. al. 2012)
-
Testis (Reproductive System)
- Perivascular Cells Testis Interstitium
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
- Pericytes Splanchnic Mesoderm
- Glial Cells
- Blood (Hematopoietic System)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Gonad
- Perivascular Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
- Hair
- Ovary (Reproductive System)
- NULL (Uncategorized)
- Spinal Cord (Nervous System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for VCAM1 Gene
This gene is overexpressed in Spleen (x15.9), Adrenal Gland (x4.2), and Kidney - Cortex (x4.0).
This gene is overexpressed in Serum (45.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VCAM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of VCAM1 Gene:
VCAM1SOURCE GeneReport for Unigene cluster for VCAM1 Gene:
Hs.109225mRNA Expression by UniProt/SwissProt for VCAM1 Gene:
P19320-VCAM1_HUMAN
Tissue specificity:
Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Evidence on tissue expression from TISSUES for VCAM1 Gene
- Heart(4.8)
- Bone marrow(4.6)
- Eye(4.4)
- Spleen(3.7)
- Blood(3.6)
- Kidney(3.4)
- Lung(3.2)
- Lymph node(3.1)
- Liver(3)
- Nervous system(3)
- Muscle(2.9)
- Intestine(2.7)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for VCAM1
-
OriGene qPCR primer pairs and template standards for VCAM1
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCAM1 Gene
Orthologs for VCAM1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VCAM1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | VCAM1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC534578 34 |
|
||
| VCAM1 35 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Vcam1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vcam1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VCAM1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | VCAM1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VCAM1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VCAM1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | vcam1 34 35 |
|
- Species where no ortholog for VCAM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for VCAM1 Gene
(1) SIMAP similar genes for VCAM1 Gene using alignment to 7 proteins:
Variants for VCAM1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000371179 | -- | 100,724,810(+) | GAGGA(A/T)GGAAG | reference, missense | |
| rs1000903747 | -- | 100,730,707(+) | GTGTG(A/G)AGAAA | intron-variant | |
| rs1001093955 | -- | 100,739,000(+) | TAAAT(A/G)TTTAG | utr-variant-3-prime | |
| rs1001199909 | -- | 100,730,806(+) | AATAT(G/T)AGGGG | intron-variant | |
| rs1001231059 | -- | 100,736,954(+) | TTAAT(A/G)CTTGT | intron-variant |
Residual Variation Intolerance Score:
30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for VCAM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAM1 Gene
Disorders for VCAM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mooren's ulcer |
|
|
| viral encephalitis |
|
|
| chronic venous insufficiency |
|
|
| shwartzman phenomenon |
|
|
| coronary artery aneurysm |
|
|
Search VCAM1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for VCAM1
No data available for UniProtKB/Swiss-Prot and Genatlas for VCAM1 Gene
Publications for VCAM1 Gene
- Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams G.T. … Kutlar A. (BMC Med. Genet. 2003) 3 22 46 64
- Alternative splicing of human VCAM-1 in activated vascular endothelium. (PMID: 1707234) Cybulsky M.I. … Collins T. (Am. J. Pathol. 1991) 3 4 22 64
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
- Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
Products for VCAM1 Gene
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Sources for VCAM1 Gene
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