Aliases for VBP1 Gene
External Ids for VBP1 Gene
Previous GeneCards Identifiers for VBP1 Gene
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
GeneCards Summary for VBP1 Gene
VBP1 (VHL Binding Protein 1) is a Protein Coding gene. Diseases associated with VBP1 include Renal Cell Carcinoma. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. GO annotations related to this gene include unfolded protein binding.
UniProtKB/Swiss-Prot for VBP1 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.