Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VBP1 Gene

protein-coding   GIFtS: 60
GCID: GC0XP154444

Von Hippel-Lindau Binding Protein 1

  See VBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Von Hippel-Lindau Binding Protein 11 2     VBP-12 3
Prefoldin 31 2     VHL-Binding Protein 12 3
Von Hippel-Lindau-Binding Protein 12 3     PFD32
HIBBJ462 3     Prefoldin Subunit 32
PFDN32 3     VHL Binding Protein-12

External Ids:    HGNC: 126621   Entrez Gene: 74112   Ensembl: ENSG000001559597   OMIM: 3001335   UniProtKB: P617583   

Export aliases for VBP1 gene to outside databases

Previous GC identifers: GC0XM148650 GC0XM150967 GC0XP151961 GC0XP152866 GC0XP154008 GC0XP154097 GC0XP142988


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for VBP1 Gene:
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex.
Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von
Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. (provided by RefSeq, Jul 2008)

GeneCards Summary for VBP1 Gene:
VBP1 (von Hippel-Lindau binding protein 1) is a protein-coding gene. Diseases associated with VBP1 include neuroblastoma. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VBP1 gene promoter:
         HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVBP1 promoter sequence
   Search Chromatin IP Primers for VBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

VBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VBP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154444:  view genomic region     (about GC identifiers)

Start:
154,425,284 bp from pter      End:
154,468,098 bp from pter
Size:
42,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758 (See protein sequence)
Recommended Name: Prefoldin subunit 3  
Size: 197 amino acids; 22658 Da
Subunit: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL
Sequence caution: Sequence=AAC23907.1; Type=Erroneous initiation;
Secondary accessions: B2R8L5 O55228 Q15765 Q5JT81 Q86X96

Explore the universe of human proteins at neXtProt for VBP1: NX_P61758

Explore proteomics data for VBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys59, Lys61, Lys82, Lys89
  • Modification sites at PhosphoSitePlus

  • See VBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003363.1  
    ENSEMBL proteins: 
     ENSP00000286428   ENSP00000438694  
    Reactome Protein details: P61758

    VBP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VBP1
    OriGene Protein Over-expression Lysate for VBP1
    OriGene MassSpec for VBP1
    OriGene Custom Protein Services for VBP1
    GenScript Custom Purified and Recombinant Proteins Services for VBP1
    Novus Biologicals VBP1 Proteins
    Novus Biologicals VBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for VBP1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for VBP1 

     
    antibodies-online proteins for VBP1 (6 products) 

     
    antibodies-online peptides for VBP1

    VBP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for VBP1
    OriGene Custom Antibody Services for VBP1
    Novus Biologicals VBP1 Antibodies
    Abcam antibodies for VBP1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for VBP1
    antibodies-online antibodies for VBP1 (32 products) 

    VBP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VBP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for VBP1 
    antibodies-online kits for VBP1 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR004127 Prefoldin_subunit_alpha
     IPR016655 Prefoldin_su-3
     IPR009053 Prefoldin

    Graphical View of Domain Structure for InterPro Entry P61758

    ProtoNet protein and cluster: P61758

    UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758
    Similarity: Belongs to the prefoldin subunit alpha family


    Find genes that share domains with VBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PFD3_HUMAN, P61758
    Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
    polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
    proteins

         Genatlas biochemistry entry for VBP1:
    von Hippel-Lindau binding protein 1,unlikely to oinvolved in renal cell carcinoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with VBP1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Vbp1):
     normal 

    Find genes that share phenotypes with VBP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target VBP1:
    hsa-mir-155-5p (MIRT020511), hsa-mir-92a-3p (MIRT048922), hsa-mir-361-5p (MIRT044083)

    Block miRNA regulation of human, mouse, rat VBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VBP1 (see all 14):
    hsa-miR-3163 hsa-miR-300 hsa-miR-146a hsa-miR-27a hsa-miR-522 hsa-miR-381 hsa-miR-3692 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidVBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VBP1
    Predesigned siRNA for gene silencing in human, mouse, rat VBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for VBP1 (see all 6)
    OriGene ORF clones in mouse, rat for VBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VBP1 (NM_003372)
    Sino Biological Human cDNA Clone for VBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VBP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for VBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PFD3_HUMAN, P61758: Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0016272prefoldin complex IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with VBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for VBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Protein folding0.91
    Chaperonin-mediated protein folding0.91
    2Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with VBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for VBP1
        Prefoldin mediated transfer of substrate to CCT/TriC


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VBP1
    Interactions:

        GeneGlobe Interaction Network for VBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VBP1 (P617581, 2, 3 ENSP000002864284) via UniProtKB, MINT, STRING, and/or I2D (see all 367)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48489 I2D: score=2 
    PIK3R3Q925692, 3MINT-8266326 I2D: score=2 
    XRCC6P129562, 3MINT-8277210 I2D: score=2 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with VBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VBP1 (PFD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VBP1 gene: 
    NM_003372.5  

    Unigene Cluster for VBP1:

    Von Hippel-Lindau binding protein 1
    Hs.436803  [show with all ESTs]
    Unigene Representative Sequence: U96759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286428(uc004fnc.3 uc004fnd.3) ENST00000460509 ENST00000459836
    ENST00000535916
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VBP1 (see all 14):
    hsa-miR-3163 hsa-miR-300 hsa-miR-146a hsa-miR-27a hsa-miR-522 hsa-miR-381 hsa-miR-3692 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidVBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VBP1
    Predesigned siRNA for gene silencing in human, mouse, rat VBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for VBP1 (see all 6)
    OriGene ORF clones in mouse, rat for VBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VBP1 (NM_003372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VBP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for VBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VBP1
      QuantiTect SYBR Green Assays in human, mouse, rat VBP1
      QuantiFast Probe-based Assays in human, mouse, rat VBP1

    Additional mRNA sequence: 

    AK301646.1 AK313420.1 BC009570.1 BC040002.1 BC046094.1 BT019604.1 CR541932.1 U56833.1 
    U96759.1 Y17394.1 

    12 DOTS entries:

    DT.92343706  DT.447718  DT.121318678  DT.100822378  DT.100822382  DT.91814280  DT.91772134  DT.121318671 
    DT.91772137  DT.100822381  DT.121318676  DT.91801616 

    Selected AceView cDNA sequences (see all 478):

    CR611663 F26994 AA253223 AA876235 CR623613 AA994806 BM541357 CR616139 
    AI264645 AA602381 CB133827 AI206805 CR612569 AI991713 BX099806 AI301193 
    CR609299 AA468651 Z41504 AI129132 BF445589 F01347 AA807208 BG494243 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VBP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -           -                                       
    SP2:                    -           -                                       
    SP3:                                -                             -         
    SP4:                                                                        
    SP5:                                -                                       


    ECgene alternative splicing isoforms for VBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTAAAAC
    VBP1 Expression
    About this image


    VBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    VBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436803

    UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for VBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for VBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VBP1
    QuantiTect SYBR Green Assays in human, mouse, rat VBP1
    QuantiFast Probe-based Assays in human, mouse, rat VBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VBP1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vbp11 , 5 von Hippel-Lindau binding protein 11, 5 91.84(n)1
    97.45(a)1
      X (38.25 cM)5
    223271  NM_011692.21  NP_035822.21 
     755142995 
    chicken
    (Gallus gallus)
    Aves VBP11 von Hippel-Lindau binding protein 1 81.73(n)
    89.34(a)
      422355  XM_420327.4  XP_420327.1 
    lizard
    (Anolis carolinensis)
    Reptilia VBP16
    von Hippel-Lindau binding protein 1
    85(a)
    1 ↔ 1
    GL343202.1(3805078-3812768)
    African clawed frog
    (Xenopus laevis)
    Amphibia vbp1-prov2 von Hippel-Lindau binding protein 1 79.96(n)    BC054252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.291112 Transcribed sequence with moderate similarity to protein more 77.28(n)    CF996671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67193
    mgr1
    'de novo' protein folding co-chaperonin3
    merry-go-round1
    57(a)3
    55.86(n)1
    53.3(a)1
      86E73
    413651  NM_141810.41  NP_650067.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T06G6.93
    pfd-31
    Human VHL binding protein like3
    pfd-31
    40(a)3
    50.88(n)1
    41.52(a)1
      I(12736107-12737760)3
    1731411  NM_060827.61  NP_493228.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PAC10(YGR078C)4
    PAC101
    Part of the heteromeric co-chaperone GimC/prefoldin more4
    PAC101
    50.62(n)1
    45.68(a)1
      7(640371-639772)4
    8529691, 4  NP_011592.31  NP_011592.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PFD31 PFD3 51.36(n)
    43.6(a)
      835011  NM_001036968.2  NP_001032045.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05629001 Os12g0562900 50.17(n)
    44.27(a)
      4352529  NM_001073564.1  NP_001067032.1 


    ENSEMBL Gene Tree for VBP1 (if available)
    TreeFam Gene Tree for VBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VBP1 (see all 292)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861497751,2
    --154311426(+) TACACC/TTTTTA 1 -- us2k10--------
    rs2011608141,2
    --154311563(+) TTACA-/TTTT  
      GTTTTG
    TTTTG
    1 -- us2k10--------
    rs1906799801,2
    --154311629(+) TTTAAA/GAAATG 1 -- us2k10--------
    rs736411201,2
    C,F--154311698(+) TAAAGT/ACCAAT 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1117309401,2
    C--154311750(+) GGAAGG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1827562891,2
    --154311810(+) CTATAA/GAGTTG 1 -- us2k10--------
    rs1865000121,2
    --154311979(+) GCGATA/GAGCTG 1 -- us2k10--------
    rs1913922431,2
    --154312275(+) GTGAAG/TAATAG 1 -- us2k10--------
    rs1830413001,2
    --154312866(+) AGTTTC/TGGAAA 1 -- us2k10--------
    rs1872052341,2
    --154313212(+) GACCCC/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VBP1 (154425284 - 154468098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29972CNV Gain17803354
    esv29815CNV Gain19812545
    nsv528909CNV Gain19592680
    esv33784CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): VBP1

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing VBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for VBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300133    OMIM disorders: --

    1 disease for VBP1:    
    About MalaCards
    neuroblastoma


    Find genes that share disorders with VBP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for VBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 27.1 2 10441001 (1), 8674032 (1)


    Export disorders for VBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VBP1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with VBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel protein (VBP-1) binding to the von Hippel- Lindau (VHL) tumor suppressor gene product. (PubMed id 8674032)1, 2, 3, 9 Tsuchiya H.... Hino O. (Cancer Res. 1996)
    2. Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. (PubMed id 9339366)1, 2, 3 Brinke A.... Giannelli F. (Genomics 1997)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PubMed id 9630229)1, 2 Vainberg I.E.... Cowan N.J. (Cell 1998)
    6. Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues. (PubMed id 9931330)1, 9 Hemberger M....Fundele R. (Hum. Mol. Genet. 1999)
    7. Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. (PubMed id 10441001)1, 9 Clifford S.C....Maher E.R. (amp 1999)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7411 HGNC: 12662 AceView: VBP1 Ensembl:ENSG00000155959 euGenes: HUgn7411
    ECgene: VBP1 H-InvDB: VBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VBP1 gene:
    Search GeneIP for patents involving VBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VBP1   OriGene RNAi products in human, mouse, rat for VBP1  
     OriGene qPCR primer pairs and template standards for VBP1   OriGene Protein Over-expression Lysate for VBP1  
     OriGene MassSpec for VBP1   OriGene clones in human, mouse for VBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for VBP1   OriGene Purified Protein for VBP1  
     OriGene ORF clones in mouse, rat for VBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VBP1   OriGene Custom Protein Services for VBP1  

     
     
     Block miRNA regulation of human, mouse, rat VBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VBP1 Predesigned siRNA for gene silencing in human, mouse, rat VBP1
     QuantiFast Probe-based Assays in human, mouse, rat VBP1 QuantiTect SYBR Green Assays in human, mouse, rat VBP1
     Custom PCR Arrays for VBP1 Search Chromatin IP Primers for VBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VBP1  GeneGlobe Interaction Network for VBP1
     Regulatory tfbs in VBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for VBP1 GenScript cDNA clones with any tag delivered in your preferred vector for VBP1
     GenScript Custom Assay Services for VBP1 GenScript Custom overexpressing Cell Line Services for VBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for VBP1 (PFD3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for VBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VBP1 antibodies
     VBP1 proteins
     VBP1 lysates
     Antibodies for VBP1
     See all of Abcam's Antibodies, Kits and Proteins for VBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for VBP1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for VBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VBP1
     SwitchGear 3'UTR luciferase reporter plasmids for VBP1
     SwitchGear Promoter luciferase reporter plasmids for VBP1
     ThermoFisher Antibodies for VBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VBP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for VBP1
      Search eBioscience for proteins for VBP1
      Search eBioscience for elisas for VBP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for VBP1
     antibodies-online antibodies for VBP1 (32 products)
     antibodies-online kits for VBP1 (18 products)
     antibodies-online peptides for VBP1
     antibodies-online proteins for VBP1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VBP1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4