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Aliases & Descriptions for VBP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HIBBJ46 3 | | OTTHUMP00000024252 2 | | PFD3 1, 2 | | PFDN3 1, 2, 3 | | VBP-1 2, 3 |
| | | Descriptions |
|---|
| VHL binding protein-1 2 | | VHL-binding protein 1 3 | | Von Hippel-Lindau-binding protein 1 3 | | prefoldin 3 2 | | von Hippel-Lindau binding protein 1 2 |
|
| | Search outside databases for aliases for VBP1 genePrevious GC identifers: GC0XM148650 GC0XM150967 GC0XP151961 GC0XP152866 GC0XP154008 |
Summaries for VBP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VBP1: The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. [provided by RefSeq] UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins |
Genomic Location for VBP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VBP1 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28VBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP154097:
(about GC identifiers)
Start:
|
154,097,744 bp from pter |
End:
|
154,121,292 bp from pter |
Size:
|
23,549 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins for VBP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758 (See
protein sequence)Recommended Name: Prefoldin subunit 3 Size: 197 amino acids; 22658 Da
Subunit: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL
Subcellular location: Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus
Secondary accessions: B2R8L5 O55228 Q15765 Q5JT81 Q86X96REFSEQ proteins: NP_003363.1
ENSEMBL proteins: ENSP00000286428
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VBP1 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VBP1: Assays for VBP1: | Protein
Domains/ Families for VBP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61758
ProtoNet protein and cluster: P61758 UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758Similarity: Belongs to the prefoldin subunit alpha family | Gene Function for VBP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003372
Applied Biosystems Silencer® siRNAs for VBP1
Sigma-Aldrich siRNA for VBP1  Sigma-Aldrich shRNA for VBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003372                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003372                                  untagged cDNA clone in CMV expression vector: NM_003372 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003372
UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteinsGenatlas biochemistry entry for VBP1:von Hippel-Lindau binding protein 1,unlikely to oinvolved in renal cell carcinoma1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051082 | unfolded protein binding |
IEA | -- | About this table | Pathways & Interactions for VBP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VBP1 
5/31 Interacting proteins for VBP1 (P617582 ENSP000002864283) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | About this table
|
Drugs & Compounds for VBP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VBP1
|
Transcripts for VBP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003372
Sigma-Aldrich siRNA for VBP1  Sigma-Aldrich shRNA for VBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003372 REFSEQ mRNAs for VBP1 gene: NM_003372.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003372               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003372                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003372                                  untagged cDNA clone in CMV expression vector: NM_003372  Additional cDNA sequence: AK301646.1 AK313420.1 BC009570.1 BC040002.1 BC046094.1 BT019604.1 CR541932.1 CR595254.1 CR596441.1 CR600706.1 CR604493.1 CR608323.1 CR609299.1 CR611663.1 CR612569.1 CR616139.1 CR616685.1 CR618821.1 CR623613.1 CR624898.1 CR625553.1 U56833.1 U96759.1 Y17394.1 12 DOTS entries: DT.92343706 DT.447718 DT.121318678 DT.100822378 DT.100822382 DT.91814280 DT.91772134 DT.121318671 DT.91772137 DT.100822381 DT.121318676 DT.91801616 24/478 AceView cDNA sequences (see all 478
):AA373354 F37214 BU628276 CR608323 AI151351 AI015896 AA775189 BM970439 W38812 CA423632 Z41853 BM459952 AA253223 AI497998 BU077548 AA789143 BC046094 CR623613 AI301193 BF445589 CB242369 BF940000 F26994 AI753943
highest scoring ESTs for VBP1:U56833 AA024631 AA027014 AA039779 AA039780 AA176288 AA181112 AA252912 AA253223 AA373354 Unigene Cluster for VBP1: Von Hippel-Lindau binding protein 1 Hs.436803 [show with all ESTs]Unigene Representative Sequence: U96759
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for VBP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VBP1
1 Ensembl transcript including schematic representation: ENST00000286428
|
Expression for VBP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VBP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VBP1
1 / 2 / 3 3 probe-sets matching VBP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAATTAAAAC
SOURCE GeneReport for Unigene cluster: Hs.436803
Expression variation in blood from EXPOLDB for VBP1 UniProtKB/Swiss-Prot: PFD3_HUMAN, P61758Tissue specificity: Ubiquitous |
Orthologs for VBP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VBP1 gene from 5/21 species (see all 21
)
About this table Species with no ortholog for VBP1
ENSEMBL Gene Tree for VBP1 | Paralogs for VBP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for VBP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VBP1 (up to first 250kb)
|
Disorders & Mutations for VBP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300133
1 Novoseek disease relationship for VBP1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
28.17 |
2 |
10441001 (1), 8674032 (1) |
About this table
1 PharmGKB disease relationship for VBP1 geneAbout this table
|
Medical News for VBP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VBP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for VBP1 gene (see all 23
):- Identification of a novel protein (VBP-1) binding to the von Hippel- Lindau (VHL) tumor suppressor gene product. (PubMed id 8674032)1, 2, 3, 4 Tsuchiya H.... Hino O. (1996)
- Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. (PubMed id 9339366)2, 3, 4 Brinke A....Giannelli F. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PubMed id 9630229)3, 4 Vainberg I.E....Cowan N.J. (1998)
- Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues. (PubMed id 9931330)1, 3 Hemberger M....Fundele R. (1999)
- Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. (PubMed id 10441001)1, 3 Clifford S.C....Maher E.R. (1999)
- von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step. (PubMed id 17698809)3 Mousnier A....Dargemont C. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. (PubMed id 15572213)3 Kralovics R. and Skoda R.C. (2005)
|
Search for VBP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VBP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VBP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VBP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VBP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VBP1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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