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Aliases for VBP1 Gene

Aliases for VBP1 Gene

  • Von Hippel-Lindau Binding Protein 1 2 3
  • HIBBJ46 3 4
  • PFDN3 3 4
  • VBP-1 3 4
  • Von Hippel-Lindau-Binding Protein 1 4
  • VHL Binding Protein-1 3
  • VHL-Binding Protein 1 4
  • Prefoldin Subunit 3 3
  • Prefoldin 3 2
  • PFD3 3

External Ids for VBP1 Gene

Summaries for VBP1 Gene

Entrez Gene Summary for VBP1 Gene

  • The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for VBP1 Gene

VBP1 (Von Hippel-Lindau Binding Protein 1) is a Protein Coding gene. Diseases associated with VBP1 include neuroblastoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for VBP1 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VBP1 Gene

Genomics for VBP1 Gene

Genomic Location for VBP1 Gene

Start:
155,197,007 bp from pter
End:
155,239,817 bp from pter
Size:
42,811 bases
Orientation:
Plus strand

Genomic View for VBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VBP1 Gene

Regulatory Elements for VBP1 Gene

Transcription factor binding sites by QIAGEN in the VBP1 gene promoter:

Proteins for VBP1 Gene

  • Protein details for VBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61758-PFD3_HUMAN
    Recommended name:
    Prefoldin subunit 3
    Protein Accession:
    P61758
    Secondary Accessions:
    • B2R8L5
    • O55228
    • Q15765
    • Q5JT81
    • Q86X96

    Protein attributes for VBP1 Gene

    Size:
    197 amino acids
    Molecular mass:
    22658 Da
    Quaternary structure:
    • Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL
    SequenceCaution:
    • Sequence=AAC23907.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for VBP1 Gene

Proteomics data for VBP1 Gene at MOPED

Post-translational modifications for VBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys59, Lys61, Lys82, and Lys89

Other Protein References for VBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VBP1 Gene

Domains for VBP1 Gene

Protein Domains for VBP1 Gene

UniProtKB/Swiss-Prot:

PFD3_HUMAN
Family:
  • Belongs to the prefoldin subunit alpha family.:
    • P61758
genes like me logo Genes that share domains with VBP1: view

No data available for Gene Families for VBP1 Gene

Function for VBP1 Gene

Molecular function for VBP1 Gene

GENATLAS Biochemistry: von Hippel-Lindau binding protein 1,unlikely to oinvolved in renal cell carcinoma
UniProtKB/Swiss-Prot Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Ontology (GO) - Molecular Function for VBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0051082 unfolded protein binding --
genes like me logo Genes that share ontologies with VBP1: view

Phenotypes for VBP1 Gene

MGI mutant phenotypes for VBP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with VBP1: view

miRNA for VBP1 Gene

miRTarBase miRNAs that target VBP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VBP1 Gene

Localization for VBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VBP1 Gene

Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VBP1 Gene COMPARTMENTS Subcellular localization image for VBP1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for VBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0016272 prefoldin complex IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with VBP1: view

Pathways for VBP1 Gene

genes like me logo Genes that share pathways with VBP1: view

Gene Ontology (GO) - Biological Process for VBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with VBP1: view

Transcripts for VBP1 Gene

Unigene Clusters for VBP1 Gene

Von Hippel-Lindau binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VBP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: -

Relevant External Links for VBP1 Gene

GeneLoc Exon Structure for
VBP1
ECgene alternative splicing isoforms for
VBP1

Expression for VBP1 Gene

mRNA expression in normal human tissues for VBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VBP1 Gene

SOURCE GeneReport for Unigene cluster for VBP1 Gene Hs.436803

mRNA Expression by UniProt/SwissProt for VBP1 Gene

P61758-PFD3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with VBP1: view

Orthologs for VBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VBP1 36
  • 100 (n)
  • 100 (a)
VBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VBP1 36
  • 91.37 (n)
  • 94.92 (a)
VBP1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VBP1 36
  • 94.42 (n)
  • 96.45 (a)
VBP1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vbp1 36
  • 91.84 (n)
  • 97.45 (a)
Vbp1 16
Vbp1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VBP1 37
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves VBP1 36
  • 81.73 (n)
  • 89.34 (a)
VBP1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VBP1 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vbp1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6377 36
vbp1 36
  • 77.43 (n)
  • 85.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.29111 36
vbp1 36
  • 71.38 (n)
  • 80.98 (a)
vbp1 37
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011165 36
  • 56.85 (n)
  • 56.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15676 37
  • 24 (a)
OneToMany
mgr 36
  • 55.86 (n)
  • 53.3 (a)
mgr 37
  • 44 (a)
OneToMany
CG6719 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea pfd-3 36
  • 50.88 (n)
  • 41.52 (a)
pfd-3 37
  • 34 (a)
OneToOne
T06G6.9 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER210C 36
  • 52.26 (n)
  • 45.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAC10 36
  • 50.62 (n)
  • 45.68 (a)
PAC10 37
  • 33 (a)
OneToOne
PAC10 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04510g 36
  • 56.1 (n)
  • 46.95 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PFD3 36
  • 51.36 (n)
  • 43.6 (a)
rice
(Oryza sativa)
Liliopsida Os12g0562900 36
  • 50.17 (n)
  • 44.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02264 36
  • 53.88 (n)
  • 46.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pac10 36
  • 50.4 (n)
  • 45.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5790 36
Species with no ortholog for VBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VBP1 Gene

ENSEMBL:
Gene Tree for VBP1 (if available)
TreeFam:
Gene Tree for VBP1 (if available)

Paralogs for VBP1 Gene

No data available for Paralogs for VBP1 Gene

Variants for VBP1 Gene

Sequence variations from dbSNP and Humsavar for VBP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1313 -- 155,239,688(-) GCTGG(C/T)CAATG utr-variant-3-prime
rs3599 -- 155,239,456(-) TTGCA(A/G)AGACA utr-variant-3-prime
rs11501 -- 155,228,429(+) ATAAC(C/T)TGTAT reference, synonymous-codon
rs11887 -- 155,239,176(-) CAGCC(A/G)ATTAG utr-variant-3-prime
rs480210 -- 155,217,737(-) CTCGA(A/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VBP1 Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV Gain+Loss 17666407
esv29972 CNV Gain 17803354
esv29815 CNV Gain 19812545
nsv528909 CNV Gain 19592680

Relevant External Links for VBP1 Gene

HapMap Linkage Disequilibrium report
VBP1
Locus Specific Mutation Databases (LSDB)
VBP1

Disorders for VBP1 Gene

(1) MalaCards Diseases for VBP1 Gene

Search for VBP1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for VBP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 27.1 2
genes like me logo Genes that share disorders with VBP1: view

No data available for UniProtKB/Swiss-Prot for VBP1 Gene

Publications for VBP1 Gene

  1. Identification of a novel protein (VBP-1) binding to the von Hippel- Lindau (VHL) tumor suppressor gene product. (PMID: 8674032) Tsuchiya H. … Hino O. (Cancer Res. 1996) 2 3 4 23
  2. Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. (PMID: 9339366) Brinke A. … Giannelli F. (Genomics 1997) 2 3 4
  3. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PMID: 9630229) Vainberg I.E. … Cowan N.J. (Cell 1998) 3 4
  4. Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues. (PMID: 9931330) Hemberger M. … Fundele R. (Hum. Mol. Genet. 1999) 3 23
  5. Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. (PMID: 10441001) Clifford S.C. … Maher E.R. (Genes Chromosomes Cancer 1999) 3 23

Products for VBP1 Gene

Sources for VBP1 Gene

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