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VAX1 Gene

protein-coding   GIFtS: 50
GCID: GC10M118878

Ventral Anterior Homeobox 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ventral Anterior Homeobox 11 2
MCOPS112 5

External Ids:    HGNC: 126601   Entrez Gene: 110232   Ensembl: ENSG000001487047   OMIM: 6042945   UniProtKB: Q5SQQ93   

Export aliases for VAX1 gene to outside databases

Previous GC identifers: GC10M117812 GC10U900019 GC10M118552 GC10M112516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAX1 Gene:
This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are
conserved in vertebrates. Genes of this family are involved in the regulation of body development and
morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs
to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is
located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral
forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAX1 Gene:
VAX1 (ventral anterior homeobox 1) is a protein-coding gene. Diseases associated with VAX1 include microphthalmia, syndromic 11, and corpus callosum agenesis. GO annotations related to this gene include chromatin DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NOTO.

UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon
guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the
neuroretina, pigmented epithelium and optic stalk (By similarity)

Gene Wiki entry for VAX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAX1 gene promoter:
         Sox5   Pax-5   Olf-1   POU6F1 (c2)   AREB6   IRF-2   Nkx6-1   Ik-2   Cart-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAX1 promoter sequence
   Search Chromatin IP Primers for VAX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.1   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

VAX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M118878:  view genomic region     (about GC identifiers)

Start:
118,888,032 bp from pter      End:
118,897,812 bp from pter
Size:
9,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9 (See protein sequence)
Recommended Name: Ventral anterior homeobox 1  
Size: 334 amino acids; 34713 Da
Secondary accessions: B1AVW5 Q6ZSX0
Alternative splicing: 2 isoforms:  Q5SQQ9-1   Q5SQQ9-2   

Explore the universe of human proteins at neXtProt for VAX1: NX_Q5SQQ9

Explore proteomics data for VAX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VAX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001106175.1  NP_954582.1  

    ENSEMBL proteins: 
     ENSP00000277905   ENSP00000358207  

    VAX1 Human Recombinant Protein Products:

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    Novus Biologicals VAX1 Protein
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    Cloud-Clone Corp. CLIAs for VAX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q5SQQ9

    ProtoNet protein and cluster: Q5SQQ9

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
    Similarity: Belongs to the EMX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    VAX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAX1_HUMAN, Q5SQQ9
    Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon
    guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the
    neuroretina, pigmented epithelium and optic stalk (By similarity)

         Genatlas biochemistry entry for VAX1:
    ventral anterior homeobox 1,specifically expressed in the developing basal forebrain and optic nerve,tightly
    linked to EMX2 in mouse and human

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0031490chromatin DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
         
    VAX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAX1:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vax1):
     cellular  craniofacial  digestive/alimentary  mortality/aging  nervous system 
     vision/eye 

    VAX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vax1tm1Grl for VAX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAX1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAX1

    miRNA
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    Block miRNA regulation of human, mouse, rat VAX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAX1 (see all 47):
    hsa-miR-4307 hsa-miR-1321 hsa-miR-3653 hsa-miR-650 hsa-miR-29b-1* hsa-miR-9 hsa-miR-298 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVAX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VAX1
    Predesigned siRNA for gene silencing in human, mouse, rat VAX1

    Gene Editing
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    OriGene clones in human, mouse for VAX1 (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAX1 (NM_001112704)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAX1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for VAX1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VAX1_HUMAN, Q5SQQ9: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    VAX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including VAX1: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for VAX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for VAX1 (ENSP000003582074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX6ENSP000003684014STRING: ENSP00000368401
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007399nervous system development ----

    VAX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VAX1 gene (2 alternative transcripts): 
    NM_001112704.1  NM_199131.2  

    Unigene Cluster for VAX1:

    Ventral anterior homeobox 1
    Hs.441536  [show with all ESTs]
    Unigene Representative Sequence: NM_199131
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277905(uc001ldb.1) ENST00000369206(uc009xyx.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat VAX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAX1 (see all 47):
    hsa-miR-4307 hsa-miR-1321 hsa-miR-3653 hsa-miR-650 hsa-miR-29b-1* hsa-miR-9 hsa-miR-298 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVAX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VAX1
    Predesigned siRNA for gene silencing in human, mouse, rat VAX1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VAX1 (NM_001112704)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for VAX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAX1
      QuantiTect SYBR Green Assays in human, mouse, rat VAX1
      QuantiFast Probe-based Assays in human, mouse, rat VAX1

    Additional mRNA sequence: 

    AK127095.1 BC101694.1 BC101696.1 

    3 DOTS entries:

    DT.101977837  DT.97815810  DT.99978132 

    3 AceView cDNA sequences:

    BU740757 NM_199131 AK127095 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTGAAA
    VAX1 Expression
    About this image


    VAX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)
             Diencephalon
    VAX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.441536
        Pathway & Disease-focused RT2 Profiler PCR Array including VAX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VAX1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vax11 , 5 ventral anterior homeobox containing gene 15
    ventral anterior homeobox 11
    88.52(n)1
    94.01(a)1
      19 (54.61 cM)5
    223261  NM_009501.11  NP_033527.11 
     591661875 
    chicken
    (Gallus gallus)
    Aves VAX11 ventral anterior homeobox 1 82.16(n)
    89.73(a)
      395582  NM_204799.1  NP_990130.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    59(a)
    many ↔ many
    GL343206.1(1542686-1556634)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004869821 ventral anterior homeobox 1b-like 81.13(n)
    92.65(a)
      100486982  XM_002943996.2  XP_002944042.2 
    zebrafish
    (Danio rerio)
    Actinopterygii vax11 ventral anterior homeobox 1 66.88(n)
    70.98(a)
      373870  NM_194410.2  NP_919391.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG185996
    --
    13(a)
    1 → many
    3R(14093510-14096895)


    ENSEMBL Gene Tree for VAX1 (if available)
    TreeFam Gene Tree for VAX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAX1 gene
    NOTO2  EN12  EMX22  EMX12  VAX22  EN22  
    2 SIMAP similar genes for VAX1 using alignment to 1 protein entry:     VAX1_HUMAN:
    VAX2    POU6F1

    VAX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAX1 (see all 195)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0673074
    Microphthalmia, syndromic, 11 (MCOPS11)4--see VAR_0673072 R S mis40--------
    rs1817491481,2
    --118888464(+) GATCTC/GTCTTT 1 -- ut310--------
    rs1463845371,2
    --118888680(+) GGCTGA/CAGTGT 1 -- ut310--------
    rs125731791,2
    C,F,H--118888772(+) cgttcC/Gtaagc 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA NA 424
    rs1397721041,2
    --118888843(+) AGTCCC/GCAGAT 1 -- ut310--------
    rs1441919791,2
    --118888847(+) CCCAGA/GTGATT 1 -- ut310--------
    rs1395968481,2
    C--118889158(+) AAGGG-/GT/GT 
    GTGTGTGT
    GTGTG
    2 -- ut310--------
    rs606178951,2
    C--118889188(+) TGTGT-/GT/GTG/GTGT/GT
    GTGTGT
    /GTGTGTGTGT
    AAATC
    5 -- ut31 cds11NA 2
    rs796760831,2
    C,F--118889445(+) TAATAG/TATGGC 1 -- ut312Minor allele frequency- T:0.13CSA WA 120
    rs1850921081,2
    --118889590(+) GGGACA/GAAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VAX1 (118888032 - 118897812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for VAX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825577CNV Gain20364138
    nsv832002CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): VAX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAX1
    DNA2.0 Custom Variant and Variant Library Synthesis for VAX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604294   
    OMIM disorders: 614402  
    UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
  • Microphthalmia, syndromic, 11 (MCOPS11) [MIM:614402]: A rare clinical entity including as main
    characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum,
    hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder of eye formation,
    ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many
    cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 12 diseases for VAX1:    
    About MalaCards
    microphthalmia, syndromic 11    corpus callosum agenesis    anophthalmia/microphthalmia    orofacial cleft
    microphthalmia    coloboma    cleft lip    cleft palate
    multiple myeloma    myeloma    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for VAX1:
    Coloboma

    VAX1 for disorders           About GeneDecksing

    GeneTests: VAX1
    GeneReviews: VAX1
    Genetic Association Database (GAD): VAX1

    Export disorders for VAX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAX1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with VAX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: The first description of a VAX1 phenotype in humans. (PubMed id 22095910)1, 2 Slavotinek A.M.... Schorderet D.F. (Hum. Mutat. 2012)
    2. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1, 4 Mangold E....NAPthen M.M. (Nat. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis. (PubMed id 10485894)1, 3 Barbieri A.M.... Banfi S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    7. Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. (PubMed id 9636075)1, 3 Hallonet M....Gruss P. (Development 1998)
    8. Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). (PubMed id 23463464)1 Butali A....Murray J.C. (Am. J. Med. Genet. A 2013)
    9. Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate. (PubMed id 23679094)1 de Aquino S.N....Coletta R.D. (BMC Med. Genet. 2013)
    10. Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate. (PubMed id 23081944)1 Nasser E....Ludwig K.U. (Birth Defects Res. Part A Clin. Mol. Teratol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11023 HGNC: 12660 AceView: VAX1 Ensembl:ENSG00000148704 euGenes: HUgn11023
    ECgene: VAX1 H-InvDB: VAX1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VAX1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=VAX1[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for VAX1 gene:
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