Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAX1 Gene

protein-coding   GIFtS: 47
GCID: GC10M118878

ventral anterior homeobox 1

 Explore 9 diseases affiliated with
VAX1 via our new
 Human Malady Compendium 
Biological research products
for VAX1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ventral Anterior Homeobox 11 2
MCOPS112

External Ids:    HGNC: 126601   Entrez Gene: 110232   Ensembl: ENSG000001487047   OMIM: 6042945   UniProtKB: Q5SQQ93   

Export aliases for VAX1 gene to outside databases

Previous GC identifers: GC10M117812 GC10U900019 GC10M118552 GC10M112516


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAX1:
This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved
in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most
conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies
in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded
protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon
guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the
neuroretina, pigmented epithelium and optic stalk (By similarity)

Gene Wiki entry for VAX1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAX1 gene promoter:
         Sox5   Pax-5   Olf-1   POU6F1 (c2)   AREB6   IRF-2   Nkx6-1   Ik-2   Cart-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.1   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

VAX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M118878:  view genomic region     (about GC identifiers)

Start:
118,888,032 bp from pter      End:
118,897,812 bp from pter
Size:
9,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9 (See protein sequence)
Recommended Name: Ventral anterior homeobox 1  
Size: 334 amino acids; 34713 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B1AVW5 Q6ZSX0
Alternative splicing: 2 isoforms:  Q5SQQ9-1   Q5SQQ9-2   

Explore the universe of human proteins at neXtProt for VAX1: NX_Q5SQQ9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5SQQ9

  • VAX1 Protein expression data from MOPED and PaxDb:    About this image 
    VAX1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001106175.1  NP_954582.1  

    ENSEMBL proteins: 
     ENSP00000277905   ENSP00000358207  

    Human Recombinant Protein Products for VAX1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: VAX1
    OriGene Protein Over-expression Lysate (see all 2): VAX1
    OriGene Custom Protein Services for VAX1 
    GenScript Custom Purified and Recombinant Proteins Services for VAX1
    Novus Biologicals VAX1 Protein
    Novus Biologicals VAX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VAX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    VAX1 for ontologies           About GeneDecksing



    VAX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VAX1 
    GenScript Custom Superior Antibodies Services for VAX1
    Novus Biologicals VAX1 Antibodies
    Abcam antibodies for VAX1 
    Uscn Antibodies for VAX1
    Search ThermoFisher Antibodies for VAX1

    Assay Products for VAX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VAX1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VAX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q5SQQ9

    ProtoNet protein and cluster: Q5SQQ9

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
    Similarity: Belongs to the EMX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAX1_HUMAN, Q5SQQ9
    Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon
    guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the
    neuroretina, pigmented epithelium and optic stalk (By similarity)

         Genatlas biochemistry entry for VAX1:
    ventral anterior homeobox 1,specifically expressed in the developing basal forebrain and optic nerve,tightly linked to
    EMX2 in mouse and human

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0031490chromatin DNA binding IEA--
         
    VAX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAX1:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vax1):
     cellular  craniofacial  digestive/alimentary  mortality/aging  nervous system 
     vision/eye 

    VAX1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Vax1tm1Grl for VAX1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VAX1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: VAX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAX1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate VAX1 (see all 47):
    hsa-miR-4307 hsa-miR-1321 hsa-miR-3653 hsa-miR-650 hsa-miR-29b-1* hsa-miR-9 hsa-miR-298 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVAX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAX1 (see all 7)
    OriGene shRNA RFP: VAX1
    OriGene siRNA: VAX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAX1
    Sirion Biotech Custom design and validation of potent shRNA sequences against VAX1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VAX1
    Sirion Biotech Customized adenovirus for overexpression of VAX1 
    Sirion Biotech Customized adenovirus for potent knockdown of VAX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VAX1 (NM_001112704)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VAX1
    Search LifeMap BioReagents cell lines for VAX1
    Sirion Biotech Customized stable knockdown cell line services for VAX1 
    Sirion Biotech Customized inducible knockdown cell line services for VAX1
    Sirion Biotech Customized stable overexpressing cell line services for VAX1
    Sirion Biotech Customized inducible overexpressing cell line services for VAX1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VAX1

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development ----

    VAX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAX1
    Search CenterWatch for drugs/clinical trials and news about VAX1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAX1 gene (2 alternative transcripts): 
    NM_001112704.1  NM_199131.2  

    Unigene Cluster for VAX1:

    Ventral anterior homeobox 1
    Hs.441536  [show with all ESTs]
    Unigene Representative Sequence: NM_199131
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277905(uc001ldb.1) ENST00000369206(uc009xyx.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: VAX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAX1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate VAX1 (see all 47):
    hsa-miR-4307 hsa-miR-1321 hsa-miR-3653 hsa-miR-650 hsa-miR-29b-1* hsa-miR-9 hsa-miR-298 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVAX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAX1 (see all 7)
    OriGene shRNA RFP: VAX1
    OriGene siRNA: VAX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAX1
    Sirion Biotech Custom design and validation of potent shRNA sequences against VAX1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VAX1 (NM_001112704)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAX1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAX1

    Additional cDNA sequence: 

    AK127095.1 BC101694.1 BC101696.1 

    3 DOTS entries:

    DT.101977837  DT.97815810  DT.99978132 

    3 AceView cDNA sequences:

    BU740757 AK127095 NM_199131 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGCTGAAA
    VAX1 Expression
    About this image

    VAX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VAX1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.441536
        SABiosciences Expression via Pathway-Focused PCR Array including VAX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VAX1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves VAX11 ventral anterior homeobox 1 75.9(n)
    82.15(a)
      395582  NM_204799.1  NP_990130.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAX16
    --
    54(a)
    1 ↔ 1
    GL343206.1(1543137-1556634)
    zebrafish
    (Danio rerio)
    Actinopterygii vax11 ventral anterior homeobox 1 68.03(n)
    72.24(a)
      373870  NM_194410.2  NP_919391.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-56
    Homeobox protein ceh-5
    37(a)
    1 → many
    I(9727195-9728012)


    ENSEMBL Gene Tree for VAX1 (if available)
    TreeFam Gene Tree for VAX1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAX1 gene
    EN12  VAX22  EN22  
    2 SIMAP similar genes for VAX1 using alignment to 1 protein entry:     VAX1_HUMAN:
    VAX2    POU6F1

    VAX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 NCBI SNPs in VAX1 are shown (see all 142    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs664944461,2
    C--118887566(+) CTCTC-/AGAT  
            
    AGTCA
    2 -- ds5001 us2k10--------
    rs105706731,2
    C--118887568(+) CTCAG-/ATAG  
            
    TCAGC
    2 -- ds5001 us2k11Minor allele frequency- ATAG:0.00NA 2
    rs1816428931,2
    --118887758(+) GACTAA/GTTTGT 2 -- ds5001 us2k10--------
    rs1876631131,2
    --118887776(+) TACACA/GGCTAT 2 -- us2k1 ds50010--------
    rs1149942511,2
    C,F--118887897(+) ATTGTA/GTGATA 2 -- us2k1 ds50011Minor allele frequency- G:0.02WA 118
    rs1919348751,2
    --118887985(+) ACATAA/GCAGAC 2 -- us2k1 ds50010--------
    rs1817491481,2
    --118888464(+) GATCTC/GTCTTT 1 -- ut310--------
    rs1463845371,2
    --118888680(+) GGCTGA/CAGTGT 1 -- ut310--------
    rs125731791,2
    C,F,H--118888772(+) cgttcC/Gtaagc 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA NA 424
    rs1397721041,2
    --118888843(+) AGTCCC/GCAGAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VAX1 (118888032 - 118897812 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VAX1: --
    Human Gene Mutation Database (HGMD): VAX1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VAX1
    DNA2.0 Custom Variant and Variant Library Synthesis for VAX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VAX1 for disorders           About GeneDecksing

    OMIM gene information: 604294    OMIM disorders: --

    UniProtKB/Swiss-Prot: VAX1_HUMAN, Q5SQQ9
  • Defects in VAX1 are the cause of microphthalmia, syndromic, type 11 (MCOPS11) [MIM:614402]. A rare clinical
  • entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of
    corpus callosum, hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder of eye
    formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In
    many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities

    9 diseases for VAX1:    About MalaCards
    anophthalmia/microphthalmia    anophthalmia    microphthalmia    cleft lip
    cleft palate    coloboma    corpus callosum agenesis    corpus callosum
    orofacial cleft

    1 disease from the University of Copenhagen DISEASES database for VAX1:
    Coloboma
    GeneTests: VAX1
    Anophthalmia/Microphthalmia


    Export disorders for VAX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAX1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with VAX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: The first description of a VAX1 phenotype in humans. (PubMed id 22095910)1, 2 Slavotinek A.M.... Schorderet D.F. (2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis. (PubMed id 10485894)1, 3 Barbieri A.M.... Banfi S. (1999)
    6. Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. (PubMed id 9636075)1, 3 Hallonet M....Gruss P. (1998)
    7. Genome-wide association study identifies two suscepti bility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1 Mangold E....NAPthen M.M. (2010)
    8. Classification and nomenclature of all human homeobox genes. (PubMed id 17963489)1 Holland P.W.H.... Bruford E.A. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11023 HGNC: 12660 AceView: VAX1 Ensembl:ENSG00000148704 euGenes: HUgn11023
    ECgene: VAX1 H-InvDB: VAX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAX1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/VAX1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAX1 gene:
    Search GeneIP for patents involving VAX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for VAX1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAX1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAX1  
     OriGene Protein Over-expression Lysate for VAX1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for VAX1   OriGene 3'-UTR Clone for VAX1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAX1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for VAX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VAX1   OriGene Custom Protein Services for VAX1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VAX1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VAX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAX1
     GenScript Custom Purified and Recombinant Proteins Services for VAX1 GenScript cDNA clones with any tag delivered in your preferred vector for VAX1
     GenScript Custom Assay Services for VAX1 GenScript Custom Superior Antibodies Services for VAX1
     GenScript Custom overexpressing Cell Line Services for VAX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VAX1 promoter
     Search Chromatin IP Primers for VAX1
     RT2 qPCR Primer Assay in human, mouse, rat VAX1
     Search GNC Networks for VAX1
     SABiosciences PCR Arrays including human, mouse, rat VAX1
     Search Tocris compounds for VAX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VAX1 antibodies
     VAX1 proteins
     VAX1 lysates
     Antibodies for VAX1
     See all of Abcam's Antibodies, Kits and Proteins for VAX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     VAX1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for VAX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAX1
     SwitchGear 3'UTR luciferase reporter plasmids for VAX1
     SwitchGear Promoter luciferase reporter plasmids for VAX1
     Search ThermoFisher Antibodies for VAX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAX1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VAX1
    Sirion Biotech Customized:
     stable knockdown cell line services for VAX1
     inducible knockdown cell line services for VAX1
     design and validation of potent shRNA sequences against VAX1
     adenovirus for potent knockdown of VAX1
     adenovirus for overexpression of VAX1
     stable overexpressing cell line services for VAX1
     inducible overexpressing cell line services for VAX1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VAX1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4