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VAV3 Gene

protein-coding   GIFtS: 65
GCID: GC01M108113

Vav 3 Guanine Nucleotide Exchange Factor

(Previous name: vav 3 oncogene)
  See VAV3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vav 3 Guanine Nucleotide Exchange Factor1 2
Vav 3 Oncogene1 2
VAV-32 3
Guanine Nucleotide Exchange Factor VAV32

External Ids:    HGNC: 126591   Entrez Gene: 104512   Ensembl: ENSG000001342157   OMIM: 6055415   UniProtKB: Q9UKW43   

Export aliases for VAV3 gene to outside databases

Previous GC identifers: GC01M108614 GC01M107096 GC01M107270 GC01M107468 GC01M107825 GC01M107915 GC01M106059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAV3 Gene:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for
Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional
alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it
associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAV3 Gene:
VAV3 (vav 3 guanine nucleotide exchange factor) is a protein-coding gene. Diseases associated with VAV3 include primary angle-closure glaucoma. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV1.

UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to
the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by
phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration
and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In
osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1
(ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling
pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound
healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils.
Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to
beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity)

Gene Wiki entry for VAV3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAV3 gene promoter:
         NF-1   AML1a   STAT3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): VAV3 promoter sequence
   Search Chromatin IP Primers for VAV3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAV3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

VAV3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M108113:  view genomic region     (about GC identifiers)

Start:
108,113,782 bp from pter      End:
108,507,766 bp from pter
Size:
393,985 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4 (See protein sequence)
Recommended Name: Guanine nucleotide exchange factor VAV3  
Size: 847 amino acids; 97776 Da
Subunit: Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2.
Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation
Sequence caution: Sequence=AAD03799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for VAV3:
2D86 (3D)    
Secondary accessions: B1AMM0 B1APV5 B4E232 B7ZLR1 E9PQ97 O60498 O95230 Q9Y5X8
Alternative promoter usage, Alternative splicing: 4 isoforms:  Q9UKW4-1   Q9UKW4-2   Q9UKW4-3   Q9UKW4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VAV3: NX_Q9UKW4

Explore proteomics data for VAV3 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in
    response to CSF1 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VAV3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073343.1  NP_006104.4  

    ENSEMBL proteins: 
     ENSP00000359073   ENSP00000432540   ENSP00000432865   ENSP00000394897   ENSP00000434944  
     ENSP00000431544   ENSP00000433559   ENSP00000446404   ENSP00000360912  
    Reactome Protein details: Q9UKW4

    VAV3 Human Recombinant Protein Products:

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    OriGene Purified Proteins for VAV3
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    OriGene Custom Protein Services for VAV3
    GenScript Custom Purified and Recombinant Proteins Services for VAV3
    Novus Biologicals VAV3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VAV3

     
    Search eBioscience for Proteins for VAV3 

     
    antibodies-online proteins for VAV3 

     
    antibodies-online peptides for VAV3

    VAV3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VAV3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for VAV3 
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    Novus Biologicals VAV3 Antibodies
    Abcam antibodies for VAV3 (Q9UKW4, P15498)
    Cloud-Clone Corp. Antibodies for VAV3
    ThermoFisher Antibodies for VAV3
    LSBio Antibodies in human, mouse, rat for VAV3
    antibodies-online antibodies for VAV3 (72 products) 

    VAV3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAV3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VAV3
    Cloud-Clone Corp. CLIAs for VAV3
    Search eBioscience for ELISAs for VAV3 
    antibodies-online kits for VAV3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 11):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q9UKW4

    ProtoNet protein and cluster: Q9UKW4

    Selected Blocks protein domains (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Find genes that share domains with VAV3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAV3_HUMAN, Q9UKW4
    Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to
    the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by
    phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration
    and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In
    osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1
    (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling
    pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound
    healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils.
    Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to
    beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity)
    Induction: Down-regulated by EGF and TGF-beta

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS10523675
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity ----
    GO:0005096GTPase activator activity TAS10523675
    GO:0005154epidermal growth factor receptor binding IEA--
         
    Find genes that share ontologies with VAV3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VAV3:
     Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vav3):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  nervous system  normal  renal/urinary system 
     vision/eye 

    Find genes that share phenotypes with VAV3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VAV3: Vav3tm1Xrb Vav3tm1Swat

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAV3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VAV3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAV3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAV3

    miRNA
    Products:
        
    miRTarBase miRNAs that target VAV3:
    hsa-mir-193b-3p (MIRT016326), hsa-mir-149-5p (MIRT045501), hsa-mir-186-5p (MIRT021094), hsa-mir-98-5p (MIRT027493)

    Block miRNA regulation of human, mouse, rat VAV3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAV3 (see all 52):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-let-7g hsa-miR-223 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidVAV3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VAV3
    Predesigned siRNA for gene silencing in human, mouse, rat VAV3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VAV3

    Clone
    Products:
         
    OriGene clones in human, mouse for VAV3 (see all 13)
    OriGene ORF clones in mouse, rat for VAV3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VAV3 (NM_001079874)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for VAV3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with VAV3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAV3 About   (see all 40)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    TCR Signaling Pathway0.36
    T cell receptor signaling pathway0.38
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    3Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    4p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    5TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    ITK and TCR Signaling0.54
    TCR Signaling0.68
    Fc-EpsilonRI Pathway0.49


    Find genes that share SuperPaths with VAV3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VAV3 (see all 16)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PI3K Signaling in B-Lymphocyte
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for VAV3
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for VAV3
        Immune response Role of DAP12 receptors in NK cells

    Selected BioSystems Pathways for VAV3 (see all 12)
        Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    BDNF signaling pathway
    TCR Signaling Pathway
    EPHA2 forward signaling

    Selected Reactome Pathways for VAV3 (see all 8)
        FCERI mediated MAPK activation
    G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle
    GPVI-mediated activation cascade


    Selected Kegg Pathways  (Kegg details for VAV3) (see all 9):
        Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VAV3
    Interactions:

        GeneGlobe Interaction Network for VAV3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAV3 (Q9UKW41, 2, 3 ENSP000003590734) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-297568,EBI-79464 MINT-7103564 MINT-7103597 I2D: score=2 STRING: ENSP00000274335
    ERBB2P046262, 3, ENSP000002695714MINT-74804 I2D: score=2 STRING: ENSP00000269571
    GRB2P629931, 2, 3, ENSP000003390074EBI-297568,EBI-401755 MINT-61544 I2D: score=5 STRING: ENSP00000339007
    SH3BP2P783142, 3, ENSP000003486854MINT-7301329 I2D: score=2 STRING: ENSP00000348685
    ALKQ9UM732, 3, ENSP000003737004MINT-8030831 I2D: score=1 STRING: ENSP00000373700
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006906vesicle fusion IEA--
    GO:0006974cellular response to DNA damage stimulus IMP17875758
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with VAV3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAV3

    Selected HMDB Compounds for VAV3 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    3 Novoseek inferred chemical compound relationships for VAV3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 34.6 9 10523675 (2), 12400014 (2), 14757747 (1), 15708849 (1)
    testosterone 27.9 18 16384856 (5), 16762975 (3), 18079321 (2), 20126983 (2)
    phosphatidylinositol 21.6 2 11884391 (1), 16762975 (1)



    Find genes that share compounds with VAV3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VAV3 gene (2 alternative transcripts): 
    NM_001079874.1  NM_006113.4  

    Unigene Cluster for VAV3:

    Vav 3 guanine nucleotide exchange factor
    Hs.267659  [show with all ESTs]
    Unigene Representative Sequence: NM_006113
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370056(uc010ouu.1 uc001dvj.1 uc010ouv.1 uc001dvk.1 uc010ouw.1)
    ENST00000527011 ENST00000529413 ENST00000525460 ENST00000415432 ENST00000343258
    ENST00000529033 ENST00000525231 ENST00000479977 ENST00000533398 ENST00000529809
    ENST00000469325(uc001dvl.1) ENST00000490388 ENST00000524574 ENST00000530671
    ENST00000544443 ENST00000371846(uc010oux.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VAV3 (see all 52):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-let-7g hsa-miR-223 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidVAV3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAV3 (NM_001079874)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAV3
      QuantiTect SYBR Green Assays in human, mouse, rat VAV3
      QuantiFast Probe-based Assays in human, mouse, rat VAV3

    Additional mRNA sequence: 

    AF035442.1 AF067817.1 AF118886.1 AF118887.1 AK097750.1 AK295166.1 AK296537.1 AK300474.1 
    AK304088.1 AK316295.1 BC143969.1 

    7 DOTS entries:

    DT.86855598  DT.92425147  DT.100020626  DT.121425328  DT.91823929  DT.121425340  DT.95178726 

    6 AceView cDNA sequences:

    BP360870 BU175456 AL713081 BF509808 AW296135 AI672033 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VAV3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:        -                 -                                                                                                     -                           
    SP2:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for VAV3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAV3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTGGGGG
    VAV3 Expression
    About this image


    VAV3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Medulla Oblongata
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
    VAV3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAV3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.267659

    UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
    Tissue specificity: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in
    skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low
    levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1
    is readily detectable

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAV3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vav31 , 5 vav 3 oncogene1, 5 90.52(n)1
    95.4(a)1
      3 (48.13 cM)5
    572571  NM_020505.21  NP_065251.21 
     1093406535 
    chicken
    (Gallus gallus)
    Aves VAV31 vav 3 guanine nucleotide exchange factor 81.28(n)
    86.29(a)
      373939  NM_206863.2  NP_996745.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAV36
    vav 3 guanine nucleotide exchange factor
    83(a)
    1 ↔ 1
    4(83182069-83409908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vav31 vav 3 guanine nucleotide exchange factor 71.97(n)
    78.03(a)
      100493918  XM_002932179.2  XP_002932225.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk86g112 Transcribed sequence with weak similarity to protein more 74.47(n)    BQ479542.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vav3 Rho protein signal transduction
    guanyl-nucleotide more
    31(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea vav-11 vav-1 46.46(n)
    36.1(a)
      181153  NM_001047757.2  NP_001041222.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC246
    Guanine nucleotide exchange factor (GEF or GDP-rel...
    16(a)
    1 → many
    I(62840-65404) YAL041W


    ENSEMBL Gene Tree for VAV3 (if available)
    TreeFam Gene Tree for VAV3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAV3 gene
    VAV12  VAV22  
    9 SIMAP similar genes for VAV3 using alignment to 6 protein entries:     VAV3_HUMAN (see all proteins):
    VAV1    ARHGEF7    SORBS3    VAV2    ITSN1    SH3GL2
    PTPN11    CNN3    GRAP

    Find genes that share paralogs with VAV3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAV3 (see all 7746)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs608066161,2
    C--106100722(+) ATATA-/TAAATAA 2 -- int11Minor allele frequency- TA:0.00NA 2
    rs671529971,2
    C--106375348(-) GTAGA-/ACATTTG 1 -- int11Minor allele frequency- AC:0.00NA 2
    rs1380327041,2
    C--108113283(+) TCTCTA/GGGATC 2 -- ds50010--------
    rs790626301,2
    C--108113329(+) ATCTCC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1118636731,2
    C--108113343(+) GATTCG/-GGGAT 2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1458538231,2
    --108113355(+) TGAACC/TGGACT 2 -- ds50010--------
    rs772938371,2
    C--108113356(+) GAACCC/GGACTC 2 -- ds50010--------
    rs747737341,2
    C--108113371(+) TCGATC/TGGCTG 2 -- ds50010--------
    rs800892931,2
    C--108113375(+) TTGGCC/TGAGGG 2 -- ds50010--------
    rs771975381,2
    C--108113385(+) GCAACA/GGAGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for VAV3 (108113782 - 108363782 bp, first 250kb of VAV3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VAV3 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675258CNV Deletion23128226
    esv2715873CNV Deletion23290073
    esv2715862CNV Deletion23290073
    esv2657612CNV Deletion23128226
    esv2669654CNV Deletion23128226
    esv2667617CNV Deletion23128226
    esv2715884CNV Deletion23290073
    esv267626CNV Insertion20981092
    esv274367CNV Insertion20981092
    esv24324CNV Loss19812545

    Human Gene Mutation Database (HGMD): VAV3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAV3
    DNA2.0 Custom Variant and Variant Library Synthesis for VAV3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605541    OMIM disorders: --

    1 disease for VAV3:    
    About MalaCards
    primary angle-closure glaucoma


    Find genes that share disorders with VAV3           About GenesLikeMe

    1 Novoseek inferred disease relationship for VAV3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 37.4 22 18676865 (5), 16762975 (3), 18079321 (3), 16384856 (2) (see all 5)

    Genetic Association Database (GAD): VAV3
    Human Genome Epidemiology (HuGE) Navigator: VAV3 (8 documents)

    Export disorders for VAV3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAV3 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with VAV3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. (PubMed id 10523675)1, 2, 9 Movilla N. and Bustelo X.R. (Mol. Cell. Biol. 1999)
    2. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2, 9 Yabana N. and Shibuya M. (Oncogene 2002)
    3. Novel associations for hypothyroidism include known autoimmune risk loci. (PubMed id 22493691)1, 4 Eriksson N....Do C.B. (PLoS ONE 2012)
    4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population. (PubMed id 20463313)1, 4 Rao K.N....Chakrabarti S. (amp 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. (PubMed id 19429868)1, 4 Jones C.I....Ouwehand W.H. (Blood 2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. (PubMed id 11094073)1, 2 Zeng L.... Wang L.H. (Mol. Cell. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10451 HGNC: 12659 AceView: VAV3.1 Ensembl:ENSG00000134215 euGenes: HUgn10451
    ECgene: VAV3 Kegg: 10451 H-InvDB: VAV3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAV3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VAV3 gene:
    Search GeneIP for patents involving VAV3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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