Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAV3 Gene

protein-coding   GIFtS: 65
GCID: GC01M108113

vav 3 guanine nucleotide exchange factor

(Previous name: vav 3 oncogene )
 Explore 16 diseases affiliated with
VAV3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VAV3    

Aliases
for VAV3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vav 3 Guanine Nucleotide Exchange Factor1 2
Vav 3 Oncogene1 2
VAV-32 3
Guanine Nucleotide Exchange Factor VAV32

External Ids:    HGNC: 126591   Entrez Gene: 104512   Ensembl: ENSG000001342157   OMIM: 6055415   UniProtKB: Q9UKW43   

Export aliases for VAV3 gene to outside databases

Previous GC identifers: GC01M108614 GC01M107096 GC01M107270 GC01M107468 GC01M107825 GC01M107915 GC01M106059


Summaries
for VAV3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VAV3:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho
family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.
This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates
maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the
nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated
EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By
similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with
SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for
osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO,
activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup
formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated
macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin
beta-1 (ITGB1)-mediated adhesion (By similarity)

Gene Wiki entry for VAV3


Genomic Views
for VAV3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAV3 gene promoter:
         NF-1   AML1a   STAT3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): VAV3 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAV3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAV3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

VAV3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M108113:  view genomic region     (about GC identifiers)

Start:
 108,113,782 bp from pter      End:
 108,507,766 bp from pter
Size:
 393,985 bases      Orientation:
 minus strand

Proteins
for VAV3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4 (See protein sequence)
Recommended Name: Guanine nucleotide exchange factor VAV3  
Size: 847 amino acids; 97776 Da
Subunit: Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2.
Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation
Sequence caution: Sequence=AAD03799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for VAV3:
2D86 (3D)    
Secondary accessions: B1AMM0 B1APV5 B4E232 B7ZLR1 E9PQ97 O60498 O95230 Q9Y5X8
Alternative promoter usage, Alternative splicing: 4 isoforms:  Q9UKW4-1   Q9UKW4-2   Q9UKW4-3   Q9UKW4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VAV3: NX_Q9UKW4

Post-translational modifications:

  • Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response
    • to CSF1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKW4

    • VAV3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073343.1  NP_006104.4  

    ENSEMBL proteins: 
     ENSP00000359073   ENSP00000432540   ENSP00000432865   ENSP00000394897   ENSP00000434944  
     ENSP00000431544   ENSP00000433559   ENSP00000446404   ENSP00000360912  
    Reactome Protein details: Q9UKW4
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): VAV3
    OriGene Protein Over-expression Lysate (see all 2): VAV3
    OriGene Custom Protein Services for VAV3 
    GenScript Custom Purified and Recombinant Proteins Services for VAV3
    Novus Biologicals VAV3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VAV3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--


    VAV3 for ontologies           About GeneDecksing



    VAV3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of VAV3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for VAV3 
    OriGene Antibodies (see all 2): VAV3
    OriGene Custom Antibody Services for VAV3 
    GenScript Custom Superior Antibodies Services for VAV3
    Novus Biologicals VAV3 Antibodies
    Abcam antibodies for VAV3 
    Uscn Antibodies for VAV3
    ThermoFisher Antibodies for VAV3

    Assay Products for VAV3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAV3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VAV3

    Protein Domains /
    Families
    for VAV3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VAV3 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR011511 SH3_2
     IPR001331 GDS_CDC24_CS
     IPR001715 CH-domain
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9UKW4

    ProtoNet protein and cluster: Q9UKW4

    5/6 Blocks protein families (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Function
    for VAV3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
    Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the
    nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated
    EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By
    similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with
    SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for
    osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO,
    activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup
    formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated
    macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin
    beta-1 (ITGB1)-mediated adhesion (By similarity)
    Induction: Down-regulated by EGF and TGF-beta

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): VAV3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAV3
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate VAV3 (see all 52):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-let-7g hsa-miR-223 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: VAV3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAV3 (see all 4)
    OriGene shRNA RFP: VAV3
    OriGene siRNA: VAV3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAV3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VAV3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VAV3 (NM_001079874)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for VAV3
    Search LifeMap BioReagents cell lines for VAV3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV3

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS10523675
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity ----
    GO:0005096GTPase activator activity TAS10523675
    GO:0005154epidermal growth factor receptor binding IEA--


    VAV3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VAV3:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for VAV3: Vav3tm1Xrb Vav3tm1Swat
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vav3):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  nervous system  normal  renal/urinary system 
     vision/eye 

    VAV3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VAV3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Cell death signalling via NRAGE, NRIF and NADE1.00
    		G alpha (12/13) signalling events0.39
    		NRAGE signals death through JNK0.74
    		Rho GTPase cycle0.25
    		p75 NTR receptor-mediated signalling0.73
    		Signaling by Rho GTPases0.25
    2PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		ITK and TCR Signaling0.54
    		TCR Signaling0.68
    		Fc-EpsilonRI Pathway0.42
    3B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    		T cell receptor signaling pathway0.40
    		TCR Signaling Pathway0.19
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5Signaling by FGFR
    		DAP12 signaling0.83
    		Signalling by NGF0.52
    		DAP12 interactions0.76

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for VAV3
        Immune response Role of DAP12 receptors in NK cells

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VAV3 (see all 16)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PI3K Signaling in B-Lymphocyte
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for VAV3
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for VAV3
        Immune response Role of DAP12 receptors in NK cells

    5/11 BioSystems Pathways for VAV3 (see all 11) 
        EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    TCR Signaling Pathway
    Regulation of RAC1 activity
    EPHA forward signaling

    5/19        Reactome Pathways for VAV3 (see all 19)
        G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE
    p75 NTR receptor-mediated signalling
    DAP12 interactions
    DAP12 signaling


    5/9         Kegg Pathways  (Kegg details for VAV3) (see all 9):
        Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway


    VAV3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAV3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for VAV3 (Q9UKW41, 2, 3 ENSP000003590734) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-7103564 MINT-7103597 I2D: score=2 STRING: ENSP00000274335
    ERBB2P046262, 3, ENSP000002695714MINT-74804 I2D: score=2 STRING: ENSP00000269571
    GRB2P629931, 2, 3, ENSP000003390074EBI-297568,EBI-401755 MINT-61544 I2D: score=5 STRING: ENSP00000339007
    SH3BP2P783142, 3, ENSP000003486854MINT-7301329 I2D: score=2 STRING: ENSP00000348685
    ALKQ9UM732, 3, ENSP000003737004MINT-8030831 I2D: score=1 STRING: ENSP00000373700
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006906vesicle fusion IEA--
    GO:0006915apoptotic process TAS--
    GO:0006974response to DNA damage stimulus IMP17875758
    GO:0007229integrin-mediated signaling pathway IEA--


    VAV3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VAV3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAV3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAV3

    10/844 HMDB Compounds for VAV3 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----
    3 Novoseek chemical compound relationships for VAV3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 34.6 9 10523675 (2), 12400014 (2), 14757747 (1), 15708849 (1)
    testosterone 27.9 18 16384856 (5), 16762975 (3), 18079321 (2), 20126983 (2)
    phosphatidylinositol 21.6 2 11884391 (1), 16762975 (1)

    Search CenterWatch for drugs/clinical trials and news about VAV3 

    Transcripts
    for VAV3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VAV3 gene (2 alternative transcripts): 
    NM_001079874.1  NM_006113.4  

    Unigene Cluster for VAV3:

    Vav 3 guanine nucleotide exchange factor
    Hs.267659  [show with all ESTs]
    Unigene Representative Sequence: NM_006113
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370056(uc010ouu.1 uc001dvj.1 uc010ouv.1 uc001dvk.1 uc010ouw.1)
    ENST00000527011 ENST00000529413 ENST00000525460 ENST00000415432 ENST00000343258
    ENST00000529033 ENST00000525231 ENST00000479977 ENST00000533398 ENST00000529809
    ENST00000469325(uc001dvl.1) ENST00000490388 ENST00000524574 ENST00000530671
    ENST00000544443 ENST00000371846(uc010oux.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): VAV3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAV3
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate VAV3 (see all 52):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-let-7g hsa-miR-223 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: VAV3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAV3 (see all 4)
    OriGene shRNA RFP: VAV3
    OriGene siRNA: VAV3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAV3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VAV3 (NM_001079874)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAV3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAV3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAV3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAV3

    Additional cDNA sequence: 

    AF035442.1 AF067817.1 AF118886.1 AF118887.1 AK097750.1 AK295166.1 AK296537.1 AK300474.1 
    AK304088.1 AK316295.1 BC143969.1 

    7 DOTS entries:

    DT.86855598  DT.92425147  DT.100020626  DT.121425328  DT.91823929  DT.121425340  DT.95178726 

    6 AceView cDNA sequences:

    AL713081 BU175456 BP360870 BF509808 AW296135 AI672033 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VAV3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:        -                 -                                                                                                     -                           
    SP2:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for VAV3

    Expression
    for VAV3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAV3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCTGGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VAV3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    KidneyRenal Collecting Duct SystemKidney
    Lower Urinary TractUreterLower Urinary Tract
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    Definitive endoderm-like cells (A scalable, suspensi...)

    See VAV3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAV3

    SOURCE GeneReport for Unigene cluster: Hs.267659

    UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4
    Tissue specificity: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal
    muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any,
    in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable

        SABiosciences Custom PCR Arrays for VAV3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAV3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAV3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAV3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAV3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV3

    Orthologs
    for VAV3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for VAV3 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves VAV31 vav 3 guanine nucleotide exchange factor 81.28(n)
    86.29(a)    		   373939  NM_206863.2  NP_996745.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VAV36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 4(83245934-83407356)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk86g112 Transcribed sequence with weak similarity to protein more 74.47(n)    BQ479542.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta vav3 Rho protein signal transduction
    guanyl-nucleotide more    		 31(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea vav-11 Protein VAV-1 46.05(n)
    35.31(a)    		   181153  NM_001047758.1  NP_001041223.1 


    ENSEMBL Gene Tree for VAV3 (if available)
    TreeFam Gene Tree for VAV3 (if available) 

    Paralogs
    for VAV3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAV3 gene
    ARHGEF62  VAV12  PLEKHG22  PLEKHG32  PREX22  ARHGEF72  TIAM12  SPATA132  
    TIAM22  ARHGEF92  VAV22  ARHGEF42  PLEKHG12  PREX12  
    9 SIMAP similar genes for VAV3 using alignment to 6 protein entries:     VAV3_HUMAN (see all proteins):
    VAV1    ARHGEF7    SORBS3    VAV2    ITSN1    SH3GL2
    PTPN11    CNN3    GRAP

    VAV3 for paralogs           About GeneDecksing



    Genomic Variants
    for VAV3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6749 NCBI SNPs in VAV3 are shown (see all 6749)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs345015501,2
    		C--106259677(+) TTTTT-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs1380327041,2
    		--108113283(+) TCTCTA/GGGATC 2 -- ds50010--------
    rs790626301,2
    		C,--108113329(+) ATCTCC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1458538231,2
    		--108113355(+) TGAACC/TGGACT 2 -- ds50010--------
    rs772938371,2
    		C--108113356(+) GAACCC/GGACTC 2 -- ds50010--------
    rs747737341,2
    		C--108113371(+) TCGATC/TGGCTG 2 -- ds50010--------
    rs800892931,2
    		C--108113375(+) TTGGCC/TGAGGG 2 -- ds50010--------
    rs771975381,2
    		C--108113385(+) GCAACA/GGAGGC 2 -- ds50010--------
    rs778429651,2
    		C,--108113398(+) TCGCCC/TGTCCA 2 -- ds50010--------
    rs618014071,2
    		C--108113438(+) ACCGAA/CTGACC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for VAV3 (108113782 - 108363782 bp, first 250kb of VAV3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for VAV3
         4 CNVs: 84440 64495 64502 4240
         2 Indels: 69494 10993
    Human Gene Mutation Database (HGMD): VAV3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VAV3
    DNA2.0 Custom Variant and Variant Library Synthesis for VAV3

    Disorders / Diseases
    for VAV3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VAV3 for disorders           About GeneDecksing

    OMIM gene information: 605541    OMIM disorders: --

    16 diseases for VAV3:    About MalaCards
    angle-closure glaucoma    primary angle-closure glaucoma    anaplastic large cell lymphoma    glaucoma
    chronic lymphocytic leukemia    lymphocytic leukemia    osteopetrosis    prostate cancer
    spasticity    pharyngitis    pancreatic cancer    leukemia
    prostatitis    breast cancer    pancreatitis    glioblastoma

    1 Novoseek disease relationship for VAV3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 37.4 22 18676865 (5), 16762975 (3), 18079321 (3), 16384856 (2) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: VAV3 (8 documents)

    Export disorders for VAV3 gene to outside databases

    Publications
    for VAV3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAV3 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with VAV3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. (PubMed id 10523675)1, 2, 9 Movilla N. and Bustelo X.R. (1999)
    2. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2, 9 Yabana N. and Shibuya M. (2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. (PubMed id 11094073)1, 2 Zeng L....Wang L.H. (2000)
    5. Non-stoichiometric reduced complexity probes for cDNA arrays. (PubMed id 9705494)1, 2 Trenkle T.... McClelland M. (1998)
    6. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. (PubMed id 18518979)1, 9 Lee K....Lu S. (2008)
    7. Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. (PubMed id 16384856)1, 9 Lyons L.S. and Burnstein K.L. (2006)
    8. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. (PubMed id 15708849)1, 9 Charvet C....Altman A. (2005)
    9. The molecular mechanism of Vav3 oncogene on upregulat ion of androgen receptor activity in prostate cancer cells. (PubMed id 20126983)1, 9 Liu Y....Lu S. (2010)
    10. Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. (PubMed id 16762975)1, 9 Dong Z....Lu S. (2006)

    External Searches for VAV3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VAV3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10451 HGNC: 12659 AceView: VAV3.1 Ensembl:ENSG00000134215 euGenes: HUgn10451
    ECgene: VAV3 Kegg: 10451 H-InvDB: VAV3

    Other Databases showing VAV3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VAV3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAV3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for VAV3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VAV3 gene:
    Search GeneIP for patents involving VAV3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for VAV3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of VAV3
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for VAV3   OriGene shRNA RFP for VAV3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAV3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAV3  
     OriGene Protein Over-expression Lysate for VAV3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for VAV3   OriGene 3'-UTR Clone for VAV3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAV3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for VAV3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VAV3   OriGene Custom Protein Services for VAV3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VAV3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VAV3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAV3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAV3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAV3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAV3
     GenScript Custom Purified and Recombinant Proteins Services for VAV3 GenScript cDNA clones with any tag delivered in your preferred vector for VAV3
     GenScript Custom Assay Services for VAV3 GenScript Custom Superior Antibodies Services for VAV3
     GenScript Custom overexpressing Cell Line Services for VAV3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for VAV3 

     Regulatory tfbs in VAV3 promoter
     Search Chromatin IP Primers for VAV3
     RT2 qPCR Primer Assay in human, mouse, rat VAV3
     GNC Network for VAV3
     SABiosciences PCR Arrays including human, mouse, rat VAV3
     Search Tocris compounds for VAV3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VAV3 antibodies
     VAV3 lysates
     Antibodies for VAV3
     See all of Abcam's Antibodies, Kits and Proteins for VAV3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     VAV3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for VAV3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV3
     SwitchGear 3'UTR luciferase reporter plasmids for VAV3
     SwitchGear Promoter luciferase reporter plasmids for VAV3
     ThermoFisher Antibodies for VAV3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      VAV3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4