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Aliases for VAV3 Gene

Aliases for VAV3 Gene

  • Vav 3 Guanine Nucleotide Exchange Factor 2 3
  • Vav 3 Oncogene 2 3
  • VAV-3 3 4
  • Guanine Nucleotide Exchange Factor VAV3 3

External Ids for VAV3 Gene

Previous GeneCards Identifiers for VAV3 Gene

  • GC01M108614
  • GC01M107096
  • GC01M107270
  • GC01M107468
  • GC01M107825
  • GC01M107915
  • GC01M108113
  • GC01M106059

Summaries for VAV3 Gene

Entrez Gene Summary for VAV3 Gene

  • This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAV3 Gene

VAV3 (Vav 3 Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Diseases associated with VAV3 include glaucoma, normal tension and primary angle-closure glaucoma. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV2.

UniProtKB/Swiss-Prot for VAV3 Gene

  • Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Gene Wiki entry for VAV3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV3 Gene

Genomics for VAV3 Gene

Regulatory Elements for VAV3 Gene

Genomic Location for VAV3 Gene

Start:
107,571,160 bp from pter
End:
107,965,144 bp from pter
Size:
393,985 bases
Orientation:
Minus strand

Genomic View for VAV3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV3 Gene

Proteins for VAV3 Gene

  • Protein details for VAV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKW4-VAV3_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor VAV3
    Protein Accession:
    Q9UKW4
    Secondary Accessions:
    • B1AMM0
    • B1APV5
    • B4E232
    • B7ZLR1
    • E9PQ97
    • O60498
    • O95230
    • Q9Y5X8

    Protein attributes for VAV3 Gene

    Size:
    847 amino acids
    Molecular mass:
    97776 Da
    Quaternary structure:
    • Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.
    SequenceCaution:
    • Sequence=AAD03799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAV3 Gene

    Alternative splice isoforms for VAV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV3 Gene

Proteomics data for VAV3 Gene at MOPED

Post-translational modifications for VAV3 Gene

  • Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAV3 Gene

No data available for DME Specific Peptides for VAV3 Gene

Domains for VAV3 Gene

Gene Families for VAV3 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for VAV3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKW4

UniProtKB/Swiss-Prot:

VAV3_HUMAN :
  • Q9UKW4
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with VAV3: view

Function for VAV3 Gene

Molecular function for VAV3 Gene

UniProtKB/Swiss-Prot Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated by EGF and TGF-beta.

Gene Ontology (GO) - Molecular Function for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10523675
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity --
GO:0005096 GTPase activator activity TAS 10523675
GO:0005154 epidermal growth factor receptor binding IEA --
genes like me logo Genes that share ontologies with VAV3: view
genes like me logo Genes that share phenotypes with VAV3: view

Animal Models for VAV3 Gene

MGI Knock Outs for VAV3:

miRNA for VAV3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VAV3 Gene

Localization for VAV3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAV3 Gene COMPARTMENTS Subcellular localization image for VAV3 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with VAV3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV3 Gene

Pathways for VAV3 Gene

genes like me logo Genes that share pathways with VAV3: view

Gene Ontology (GO) - Biological Process for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006906 vesicle fusion IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 17875758
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with VAV3: view

Compounds for VAV3 Gene

(844) HMDB Compounds for VAV3 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available

(3) Novoseek inferred chemical compound relationships for VAV3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 34.6 6
testosterone 27.9 12
phosphatidylinositol 21.6 2
genes like me logo Genes that share compounds with VAV3: view

Transcripts for VAV3 Gene

mRNA/cDNA for VAV3 Gene

Unigene Clusters for VAV3 Gene

Vav 3 guanine nucleotide exchange factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAV3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: - - -
SP2:

ExUns: 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:

Relevant External Links for VAV3 Gene

GeneLoc Exon Structure for
VAV3
ECgene alternative splicing isoforms for
VAV3

Expression for VAV3 Gene

mRNA expression in normal human tissues for VAV3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (6.3), Esophagus - Mucosa (5.6), Skin - Sun Exposed (Lower leg) (5.5), and Kidney - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VAV3 Gene

SOURCE GeneReport for Unigene cluster for VAV3 Gene Hs.267659

mRNA Expression by UniProt/SwissProt for VAV3 Gene

Q9UKW4-VAV3_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
genes like me logo Genes that share expressions with VAV3: view

Orthologs for VAV3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAV3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAV3 35
  • 93.11 (n)
  • 96.1 (a)
VAV3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAV3 35
  • 91.7 (n)
  • 95.28 (a)
VAV3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vav3 35
  • 90.52 (n)
  • 95.4 (a)
Vav3 16
Vav3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAV3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vav3 35
  • 89.57 (n)
  • 94.81 (a)
chicken
(Gallus gallus)
Aves VAV3 35
  • 81.28 (n)
  • 86.29 (a)
VAV3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAV3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vav3 35
  • 71.97 (n)
  • 78.03 (a)
zebrafish
(Danio rerio)
Actinopterygii VAV3 (1 of 3) 36
  • 76 (a)
OneToMany
vav3a 36
  • 67 (a)
OneToMany
vav3b 35
  • 68.21 (n)
  • 70.85 (a)
vav3b 36
  • 70 (a)
OneToMany
wufk86g11 35
fruit fly
(Drosophila melanogaster)
Insecta vav 36
  • 27 (a)
OneToMany
vav 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea vav-1 35
  • 46.46 (n)
  • 36.1 (a)
vav-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 36
  • 35 (a)
OneToMany
Species with no ortholog for VAV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV3 Gene

ENSEMBL:
Gene Tree for VAV3 (if available)
TreeFam:
Gene Tree for VAV3 (if available)

Paralogs for VAV3 Gene

Paralogs for VAV3 Gene

Selected SIMAP similar genes for VAV3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with VAV3: view

Variants for VAV3 Gene

Sequence variations from dbSNP and Humsavar for VAV3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8458 -- 107,571,234(-) TAATA(C/T)GGTGA utr-variant-3-prime
rs8676 -- 107,571,243(-) GCCCT(C/T)GTGTA utr-variant-3-prime
rs76592 -- 107,939,571(-) ggatg(C/G)aaaac intron-variant
rs189375 -- 107,960,760(+) aaaca(G/T)tgaca intron-variant
rs191503 -- 107,866,823(-) ttttt(G/T)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAV3 Gene

Variant ID Type Subtype PubMed ID
nsv830993 CNV Gain 17160897
nsv872134 CNV Loss 21882294
esv2715862 CNV Deletion 23290073
esv274367 CNV Insertion 20981092
esv267626 CNV Insertion 20981092
nsv463073 CNV Loss 19166990
nsv872135 CNV Loss 21882294
nsv463084 CNV Loss 19166990
esv25310 CNV Gain 19812545
esv2715873 CNV Deletion 23290073
esv2667617 CNV Deletion 23128226
nsv831004 CNV Gain 17160897
esv2657612 CNV Deletion 23128226
nsv523448 CNV Loss 19592680
nsv831015 CNV Gain 17160897
esv24324 CNV Loss 19812545
nsv524680 CNV Gain 19592680
esv2669654 CNV Deletion 23128226
esv2715884 CNV Deletion 23290073
nsv823831 CNV Loss 20364138
esv2675258 CNV Deletion 23128226
esv24698 CNV Loss 19812545
esv33860 CNV Gain 17666407

Relevant External Links for VAV3 Gene

HapMap Linkage Disequilibrium report
VAV3
Human Gene Mutation Database (HGMD)
VAV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAV3 Gene

Disorders for VAV3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for VAV3 Gene including...

Search for VAV3 Gene in MalaCards »

(1) Novoseek inferred disease relationships for VAV3 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 37.4 14

Relevant External Links for VAV3

Genetic Association Database (GAD)
VAV3
Human Genome Epidemiology (HuGE) Navigator
VAV3
genes like me logo Genes that share disorders with VAV3: view

No data available for UniProtKB/Swiss-Prot for VAV3 Gene

Publications for VAV3 Gene

  1. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. (PMID: 10523675) Movilla N. … Bustelo X.R. (Mol. Cell. Biol. 1999) 3 4 23
  2. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PMID: 12400014) Yabana N. … Shibuya M. (Oncogene 2002) 3 4 23
  3. Differential regulation of TCR-mediated gene transcription by Vav family members. (PMID: 14757747) Zakaria S. … Billadeau D.D. (J. Exp. Med. 2004) 3 23
  4. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. (PMID: 15708849) Charvet C. … Altman A. (J. Biol. Chem. 2005) 3 23
  5. Vav family proteins couple to diverse cell surface receptors. (PMID: 10938113) Moores S.L. … Swat W. (Mol. Cell. Biol. 2000) 3 23

Products for VAV3 Gene

Sources for VAV3 Gene

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