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VAV3 Gene

protein-coding GIFtS: 62

GC01M107915

vav 3 guanine nucleotide exchange factor
(Previous name: vav 3 oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ40431 ^²
OTTHUMP00000012665 ^²
VAV-3 ^³

Descriptions
vav 3 guanine nucleotide exchange factor ^²
vav 3 oncogene ^¹, ²

External Ids
HGNC: 12659¹
Entrez Gene: 10451²
UniProtKB: Q9UKW4³
Ensembl: ENSG00000134215⁷

Search outside databases for aliases for VAV3 gene

Previous GC identifers: GC01M108614 GC01M107096 GC01M107270 GC01M107468 GC01M107825

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VAV3:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange

factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal

rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for

RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free

states of these GTPases. Alternatively spliced transcript variants encoding different isoforms

have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4

Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds

physically to the nucleotide-free states of those GTPases

Gene Wiki entry for VAV3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VAV3 gene

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3

VAV3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M107915: (about GC identifiers)

Start:	107,915,305 bp from pter
End:	108,309,068 bp from pter
Size:	393,764 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4 (See protein sequence)

Recommended Name: Guanine nucleotide exchange factor VAV3

Size: 847 amino acids; 97776 Da

Subunit: Interacts with the PH domain of APS

PDB structures from and Proteopedia :

2D86 (3D)

Secondary accessions: B1AMM0 O95230 Q9Y5X8

Alternative splicing: 2 isoforms: Q9UKW4-1 Q9UKW4-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001073343.1 NP_006104.4

ENSEMBL proteins:

ENSP00000359073 ENSP00000344267

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Vav proteins, VAV3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for VAV3:

	Invitrogen Antibodies for VAV3
	Millipore Mono- and Polyclonal Antibodies for the study of VAV3
	Sigma-Aldrich Antibodies for VAV3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for VAV3
	Antibodies from Abcam (Vav proteins, VAV3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VAV3)
	Novus Biologicals Antibodies for VAV3

Assays for VAV3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UKW4

ProtoNet protein and cluster: Q9UKW4

5/6 Blocks protein families (see all 6 ):

IPB000219 DH domain

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001715 Calponin-like actin-binding

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079874

Applied Biosystems Silencer® siRNAs for VAV3

Sigma-Aldrich siRNA and siRNA Panels for VAV3

Sigma-Aldrich shRNA for VAV3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079874
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079874
untagged cDNA clones in CMV expression vector (see all 2): NM_001079874

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006113

UniProtKB/Swiss-Prot: VAV3_HUMAN, Q9UKW4

Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds

physically to the nucleotide-free states of those GTPases

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vav3):

	cellular	hematopoietic system	homeostasis/metabolism	immune system
muscle	nervous system	renal/urinary system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	10523675
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005096	GTPase activator activity	TAS	10523675
GO:0005515	protein binding	IPI	18518979

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for VAV3 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Leukocyte Extravasation Signaling
T Cell Receptor Signaling
Actin Cytoskeleton Signaling
Natural Killer Cell Signaling
Fc Epsilon RI Signaling

GeneDecks VAV3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VAV3

5/103 Interacting proteins for VAV3 (ENSP00000359073³ Q9UKW4^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 103 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993²	STRING (score=.745) MINT-61544
ESR1	P03372¹	EBI-297568, EBI-78473
ERBB2	P04626²	MINT-74804
ERBB3	P21860²	MINT-74805
LCP2	ENSP00000046794³	STRING (score=.987)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	TAS	10523675
GO:0035023	regulation of Rho protein signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VAV3
2 Novoseek chemical compound relationships for VAV3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	37.99	9	10523675 (2), 12400014 (2), 14757747 (1), 15708849 (1)
phosphatidylinositol	25.08	2	11884391 (1), 16762975 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079874

Sigma-Aldrich siRNA and siRNA Panels for VAV3

Sigma-Aldrich shRNA for VAV3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079874 NM_006113

REFSEQ mRNAs for VAV3 gene (2 alternative transcripts):

NM_001079874.1 NM_006113.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079874 NM_006113

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079874
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079874
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001079874

Additional cDNA sequence:

AF035442.1 AF067817.1 AF118886.1 AF118887.1 AK097750.1 AK295166.1 AK296537.1 AK300474.1

AK304088.1 AK316295.1 BC143969.1 CR611410.1

7 DOTS entries:

DT.86855598 DT.92425147 DT.100020626 DT.91823929 DT.121425328 DT.121425340 DT.95178726

6 AceView cDNA sequences:

AL713081 BP360870 BU175456 BF509808 AW296135 AI672033

highest scoring ESTs for VAV3:

AF067817 AF118887 AW296135 BF509808 W91952 AA468526 AA488848 AA488919 AA514367 AA574117

Unigene Cluster for VAV3:

Vav 3 guanine nucleotide exchange factor

Hs.267659 [show with all ESTs]

Unigene Representative Sequence: NM_006113

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for VAV3

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:			-						-																																		-
SP2:

ExUns:	27	^	28	^	29	^	30
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for VAV3

2 Ensembl transcripts including schematic representations:

ENST00000370056 ENST00000343258

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VAV3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VAV3

¹ / ² / ³

8 probe-sets matching VAV3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51291_at²^{, 3}	U95-B	1	1.00	1.00	0.99	1.00	W91952	0.80	1.00	0.91	1
51289_at²^{, 3}	U95-B	1	0.62	1.00	0.97	1.01	C00414	0.60	1.00	0.82	1
218806_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF118887	0.80	1.00	0.91	1
224221_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF118886	0.60	1.00	0.82	1
218807_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006113	0.60	1.00	0.82	1
218806_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224221_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218807_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VAV3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCTGGGGG

SOURCE GeneReport for Unigene cluster: Hs.267659

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VAV3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAV3¹	--	vav 3 guanine nucleotide exchange factor	92.87(n) 97.06(a)	479921 XM_537047.2 XP_537047.2
cow (Bos taurus)	VAV3¹	--	vav 3 guanine nucleotide exchange factor	94.08(n) 97.46(a)	521961 XM_615898.3 XP_615898.3
rat (Rattus norvegicus)	Vav3¹	--	vav 3 guanine nucleotide exchange factor	89.57(n) 94.81(a)	295378 XM_227600.4 XP_227600.4
mouse (Mus musculus)	Vav3^{1, 5}	3⁵	vav 3 oncogene^{1, 5}	90.52(n)¹ 95.4(a)¹	57257¹ NM_020505.2¹ NP_065251.2¹ AA986410⁵ AF067816⁵ (see all 16)
chicken (Gallus gallus)	VAV3¹	--	vav 3 oncogene	81.28(n) 86.29(a)	373939 NM_206863.2 NP_996745.1

About this table Species with no ortholog for VAV3

ENSEMBL Gene Tree for VAV3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VAV3 gene

VAV1² TIAM2² VAV2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2216 NCBI SNPs in VAV3 are shown (see all 2216 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 777)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2769668^1,2	C,F,H,O	107916668(-)	`TATTAG/AGGGTA`	2	--	ut3¹		7	EU EA WA NA	556
	rs7528153^1,2	A,C,F,H	108109250(+)	`TTTTGA/TCTTAG`	1	T/S	mis¹ ese³		19	EA NA EU WA	1722
	rs8458^1,2	C,F,H,O	107915379(-)	`TAATAC/TGGTGA`	2	--	ut3¹		10	MN EU EA WA NA	998
	rs3761900^1,2	A,C,F,H	108310790(-)	`TCACTA/GTCCTG`	1	--	ng3¹		9	EA EU WA	1748
	rs12403266^1,2	A,C,F,H	107986824(+)	`TGGAGC/GTGTAA`	2	Q/H	mis¹ ese³		9	EU EA WA NA	908
	rs12410676^1,2	C,F,H	107986832(+)	`TAAAGG/AGGGTC`	2	S/P	mis¹ ese³		9	EU EA WA NA	916
	rs3761902^1,2	C,F,H	108309888(-)	`GGAAAT/CAGGCT`	1	--	ng3¹		5	EA EU WA	1880
	rs8676^1,2	C,F,H	107915388(-)	`GCCCTT/CGTGTA`	2	--	ut3¹ ese³		8	EU EA WA NA MN	730
	rs3790682^1,2	C,F,H	107915186(-)	`GTGAAC/GAGAAG`	2	--	ng5¹		7	NA EU EA WA	558
	rs7527291^1,2	C,F,H	108033913(+)	`AACACA/GTAACG`	2	--	int¹ ng3¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for VAV3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605541

1 Novoseek disease relationship for VAV3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	36.03	20	18676865 (5), 16762975 (3), 18079321 (3), 16384856 (2)

About this table

Human Genome Epidemiology Navigator: VAV3 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/33 PubMed articles for VAV3 gene (see all 33 ):

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. (PubMed id 10523675)^{1, 3, 4} Movilla N. and Bustelo X.R. (1999)
Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)^{1, 3, 4} Yabana N. and Shibuya M. (2002)
Non-stoichiometric reduced complexity probes for cDNA arrays. (PubMed id 9705494)^{3, 4} Trenkle T.... McClelland M. (1998)
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. (PubMed id 18518979)^{1, 3} Lee K....Lu S. (2008)
Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. (PubMed id 16384856)^{1, 3} Lyons L.S. and Burnstein K.L. (2006)
Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. (PubMed id 15708849)^{1, 3} Charvet C....Altman A. (2005)
Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. (PubMed id 16762975)^{1, 3} Dong Z....Lu S. (2006)
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer. (PubMed id 18079321)^{1, 3} Lyons L.S....Burnstein K.L. (2008)
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. (PubMed id 11805146)^{1, 3} Inabe K....Kurosaki T. (2002)
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. (PubMed id 19008376)^{1, 3} Salhia B....Rutka J.T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10451	HGNC: 12659	AceView: VAV3.1	Ensembl:ENSG00000134215	euGenes: HUgn10451
ECgene: VAV3	H-InvDB: VAV3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for VAV3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for VAV3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VAV3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VAV3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VAV3		Antibodies for VAV3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VAV3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (VAV3)
	Chimera RNAi (VAV3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for VAV3

	Recombinant Proteins (Vav proteins, VAV3)
	Antibodies (Vav proteins, VAV3)

Search OriGene for VAV3

Search Tocris compounds for VAV3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VAV3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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VAV3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for VAV3

Summaries
for VAV3

Genomic Location
for VAV3

Proteins
for VAV3

Protein Domains/
Families
for VAV3

Gene Function
for VAV3

Pathways & Interactions
for VAV3

Drugs & Compounds
for VAV3

Transcripts
for VAV3

Expression
for VAV3

Orthologs
for VAV3

Paralogs
for VAV3

SNPs/Variants
for VAV3

Disorders & Mutations
for VAV3

Medical News
for VAV3

Publications
for VAV3

Search for VAV3

Genome Databases showing VAV3

Other Databases showing VAV3

Specialized Databases showing VAV3

Licensable Technologies
for VAV3

Services
for VAV3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VAV3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor VAV3

Summariesfor VAV3

Genomic Locationfor VAV3

Proteinsfor VAV3

Protein Domains/Familiesfor VAV3

Gene Functionfor VAV3

Pathways & Interactionsfor VAV3

Drugs & Compoundsfor VAV3

Transcriptsfor VAV3

Expression for VAV3

Orthologsfor VAV3

Paralogsfor VAV3

SNPs/Variantsfor VAV3

Disorders & Mutationsfor VAV3

Medical Newsfor VAV3

Publicationsfor VAV3

Search for VAV3

Genome Databases showing VAV3

Other Databases showing VAV3

Specialized Databases showing VAV3

Licensable Technologiesfor VAV3

Servicesfor VAV3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VAV3

Summaries
for VAV3

Genomic Location
for VAV3

Proteins
for VAV3

Protein Domains/
Families
for VAV3

Gene Function
for VAV3

Pathways & Interactions
for VAV3

Drugs & Compounds
for VAV3

Transcripts
for VAV3

Expression
for VAV3

Orthologs
for VAV3

Paralogs
for VAV3

SNPs/Variants
for VAV3

Disorders & Mutations
for VAV3

Medical News
for VAV3

Publications
for VAV3

Licensable Technologies
for VAV3

Services
for VAV3