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Aliases for VAV3 Gene

Aliases for VAV3 Gene

  • Vav Guanine Nucleotide Exchange Factor 3 2 3 5
  • Vav 3 Guanine Nucleotide Exchange Factor 2 3
  • Vav 3 Oncogene 2 3
  • VAV-3 3 4
  • Guanine Nucleotide Exchange Factor VAV3 3

External Ids for VAV3 Gene

Previous GeneCards Identifiers for VAV3 Gene

  • GC01M108614
  • GC01M107096
  • GC01M107270
  • GC01M107468
  • GC01M107825
  • GC01M107915
  • GC01M108113
  • GC01M106059

Summaries for VAV3 Gene

Entrez Gene Summary for VAV3 Gene

  • This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAV3 Gene

VAV3 (Vav Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with VAV3 include Glaucoma, Normal Tension. Among its related pathways are p75 NTR receptor-mediated signalling and Mesodermal Commitment Pathway. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV1.

UniProtKB/Swiss-Prot for VAV3 Gene

  • Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Gene Wiki entry for VAV3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV3 Gene

Genomics for VAV3 Gene

Regulatory Elements for VAV3 Gene

Enhancers for VAV3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G107784 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.3 +178.8 178828 3.3 HDAC1 CTCF ETV1 CEBPG ZBTB40 RAD21 FOSL1 GATA3 GATA2 NCOR1 VAV3 VAV3-AS1 GC01P107703 MIR7852
GH01G107802 1.4 FANTOM5 Ensembl ENCODE dbSUPER 37.2 +160.6 160604 3.7 MNT RAD21 FOXA1 CTBP1 ZBTB33 ZNF24 ETV6 FOSL2 FOS VAV3 VAV3-AS1 MIR7852 GC01P107703
GH01G107824 1.1 Ensembl ENCODE dbSUPER 38.3 +137.2 137245 6.0 GATA3 MTA2 ETV6 TBX21 ZBTB40 ATF2 TCF7L2 FOXA1 VAV3 VAV3-AS1 MIR7852 GC01P107703
GH01G107934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21 +28.8 28788 4.1 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A FEZF1 CBX5 ZNF143 FOS JUNB PRPF38B VAV3 VAV3-AS1 MIR7852
GH01G107839 0.9 Ensembl ENCODE dbSUPER 36.9 +123.9 123873 3.8 TBX21 SPI1 VAV3 VAV3-AS1 MIR7852 GC01P107703
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAV3 on UCSC Golden Path with GeneCards custom track

Promoters for VAV3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010929 244 2600 TBL1XR1 SIN3A ZNF2 GLIS2 ETV6 IKZF2 JUNB ZEB2 GATAD2B ZNF579

Genomic Location for VAV3 Gene

Chromosome:
1
Start:
107,571,160 bp from pter
End:
107,965,144 bp from pter
Size:
393,985 bases
Orientation:
Minus strand

Genomic View for VAV3 Gene

Genes around VAV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV3 Gene

Proteins for VAV3 Gene

  • Protein details for VAV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKW4-VAV3_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor VAV3
    Protein Accession:
    Q9UKW4
    Secondary Accessions:
    • B1AMM0
    • B1APV5
    • B4E232
    • B7ZLR1
    • E9PQ97
    • O60498
    • O95230
    • Q9Y5X8

    Protein attributes for VAV3 Gene

    Size:
    847 amino acids
    Molecular mass:
    97776 Da
    Quaternary structure:
    • Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.
    SequenceCaution:
    • Sequence=AAD03799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAV3 Gene

    Alternative splice isoforms for VAV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV3 Gene

Post-translational modifications for VAV3 Gene

  • Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAV3 (VAV3)

No data available for DME Specific Peptides for VAV3 Gene

Domains & Families for VAV3 Gene

Suggested Antigen Peptide Sequences for VAV3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VAV3: view

No data available for UniProtKB/Swiss-Prot for VAV3 Gene

Function for VAV3 Gene

Molecular function for VAV3 Gene

UniProtKB/Swiss-Prot Function:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by EGF and TGF-beta.

Gene Ontology (GO) - Molecular Function for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10523675
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS,IEA --
GO:0005096 GTPase activator activity TAS 10523675
GO:0005154 epidermal growth factor receptor binding IEA --
genes like me logo Genes that share ontologies with VAV3: view
genes like me logo Genes that share phenotypes with VAV3: view

Animal Models for VAV3 Gene

MGI Knock Outs for VAV3:

Animal Model Products

CRISPR Products

miRNA for VAV3 Gene

miRTarBase miRNAs that target VAV3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV3 Gene

Localization for VAV3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAV3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with VAV3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV3 Gene

Pathways & Interactions for VAV3 Gene

genes like me logo Genes that share pathways with VAV3: view

SIGNOR curated interactions for VAV3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006906 vesicle fusion IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 17875758
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007264 small GTPase mediated signal transduction TAS,IEA --
genes like me logo Genes that share ontologies with VAV3: view

Drugs & Compounds for VAV3 Gene

(3) Drugs for VAV3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for VAV3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with VAV3: view

Transcripts for VAV3 Gene

mRNA/cDNA for VAV3 Gene

(8) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VAV3 Gene

Vav 3 guanine nucleotide exchange factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAV3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: - - -
SP2:

ExUns: 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:

Relevant External Links for VAV3 Gene

GeneLoc Exon Structure for
VAV3
ECgene alternative splicing isoforms for
VAV3

Expression for VAV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAV3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.3), Esophagus - Mucosa (x5.6), Skin - Sun Exposed (Lower leg) (x5.5), and Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for VAV3 Gene

This gene is overexpressed in Monocytes (15.4), Peripheral blood mononuclear cells (15.3), Plasma (14.8), and Lymph node (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VAV3 Gene



Protein tissue co-expression partners for VAV3 Gene

NURSA nuclear receptor signaling pathways regulating expression of VAV3 Gene:

VAV3

SOURCE GeneReport for Unigene cluster for VAV3 Gene:

Hs.267659

mRNA Expression by UniProt/SwissProt for VAV3 Gene:

Q9UKW4-VAV3_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.

Evidence on tissue expression from TISSUES for VAV3 Gene

  • Skin(4.3)
  • Nervous system(2.8)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with VAV3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VAV3 Gene

Orthologs for VAV3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAV3 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAV3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAV3 34 35
  • 93.11 (n)
dog
(Canis familiaris)
Mammalia VAV3 34 35
  • 91.7 (n)
mouse
(Mus musculus)
Mammalia Vav3 34 16 35
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia Vav3 34
  • 89.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves VAV3 34 35
  • 81.28 (n)
lizard
(Anolis carolinensis)
Reptilia VAV3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vav3 34
  • 71.97 (n)
zebrafish
(Danio rerio)
Actinopterygii VAV3 (1 of 3) 35
  • 76 (a)
OneToMany
vav3b 34 35
  • 68.21 (n)
vav3a 35
  • 67 (a)
OneToMany
wufk86g11 34
fruit fly
(Drosophila melanogaster)
Insecta vav 36 35
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea vav-1 34 35
  • 46.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 35
  • 35 (a)
OneToMany
Species where no ortholog for VAV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV3 Gene

ENSEMBL:
Gene Tree for VAV3 (if available)
TreeFam:
Gene Tree for VAV3 (if available)

Paralogs for VAV3 Gene

Paralogs for VAV3 Gene

(9) SIMAP similar genes for VAV3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with VAV3: view

Variants for VAV3 Gene

Sequence variations from dbSNP and Humsavar for VAV3 Gene