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VAV2 Gene

protein-coding GIFtS: 63

GC09M135616

vav 2 guanine nucleotide exchange factor
(Previous name: vav 2 oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
OTTHUMP00000022509 ^²
VAV-2 ^³

Descriptions
Protein vav-2 ^²
oncogene VAV2 ^²
vav 2 guanine nucleotide exchange factor ^²
vav 2 oncogene ^¹, ²

External Ids
HGNC: 12658¹
Entrez Gene: 7410²
UniProtKB: P52735³
Ensembl: ENSG00000160293⁷

Search outside databases for aliases for VAV2 gene

Previous GC identifers: GC09M127703 GC09M128297 GC09M130051 GC09M131970 GC09M131968 GC09M133657

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VAV2:

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike

VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most

tissues. Alternatively spliced transcript variants encoding different isoforms have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735

Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases

Gene Wiki entry for VAV2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VAV2 gene

Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34.1

VAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M135616: (about GC identifiers)

Start:	135,616,837 bp from pter
End:	135,847,547 bp from pter
Size:	230,711 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735 (See protein sequence)

Recommended Name: Guanine nucleotide exchange factor VAV2

Size: 878 amino acids; 101289 Da

PDB structure from and Proteopedia :

2DLZ (3D)

2DM1 (3D)

Secondary accessions: A2RUM4 A8MQ12 Q5SYV3 Q5SYV4 Q5SYV5 Q6N012 Q6PIJ9 Q6Q317

Alternative splicing: 3 isoforms: P52735-1 P52735-2 P52735-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001127870.1 NP_003362.2

ENSEMBL proteins:

ENSP00000360912 ENSP00000317258 ENSP00000385362 ENSP00000344167 ENSP00000360916 ENSP00000360917

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Vav proteins, VAV2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for VAV2:

	Invitrogen Antibodies for VAV2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for VAV2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for VAV2
	Antibodies from Abcam (Vav proteins, VAV2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VAV2)
	Novus Biologicals Antibodies for VAV2

Assays for VAV2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P52735

ProtoNet protein and cluster: P52735

5/6 Blocks protein families (see all 6 ):

IPB000219 DH domain

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001715 Calponin-like actin-binding

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001134398

Applied Biosystems Silencer® siRNAs for VAV2

Sigma-Aldrich siRNA for VAV2

Sigma-Aldrich shRNA Panels and shRNA for VAV2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134398
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134398
untagged cDNA clones in CMV expression vector (see all 3): NM_001134398

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001134398

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735

Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases

Genatlas biochemistry entry for VAV2:

VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same

region

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vav2):

	cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	muscle	nervous system	renal/urinary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	15618286
GO:0008270	zinc ion binding	IEA	--
GO:0019992	diacylglycerol binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for VAV2 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Leukocyte Extravasation Signaling
Natural Killer Cell Signaling
T Cell Receptor Signaling
B Cell Receptor Signaling
Fc&gamma

GeneDecks VAV2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for VAV2

5/138 Interacting proteins for VAV2 (ENSP00000317258³ P52735^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 138 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NEK3	P51956¹	STRING (score=.884) EBI-297549, EBI-476041
PRLR	P16471¹	STRING (score=.775) EBI-297549, EBI-476182
ERBB3	P21860²	STRING (score=.73) MINT-74803
ERBB2	P04626²	MINT-74801 MINT-74800 MINT-74802
CD19	ENSP00000313419³	STRING (score=.995)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007242	intracellular signaling cascade	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VAV2
4 Novoseek chemical compound relationships for VAV2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	62.88	38	11516622 (3), 10982832 (3), 15485841 (2), 16170364 (2) (see all 17)
gtp	55.62	5	15485841 (1), 16170364 (1), 17996485 (1), 12411320 (1)
phosphatidylinositol	33.22	6	12454019 (2), 16170364 (1), 12955089 (1), 18387945 (1)
calcium	0.00	5	11080163 (2)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001134398

Sigma-Aldrich siRNA for VAV2

Sigma-Aldrich shRNA Panels and shRNA for VAV2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001134398 NM_003371

REFSEQ mRNAs for VAV2 gene (2 alternative transcripts):

NM_001134398.1 NM_003371.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001134398 NM_003371

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134398
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134398
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001134398

Additional cDNA sequence: AK130575.1

11 DOTS entries:

DT.415120 DT.101968052 DT.100755376 DT.40296426 DT.95113897 DT.100728201 DT.121156304 DT.91663125

DT.91758100 DT.91758101 DT.95306291

1 AceView cDNA sequence:

AK130575

highest scoring ESTs for VAV2:

S76992 AI797809 AW296528 BF940723 BX640754 AA279260 AA279261 AA310654 AA412620 AA464959

Unigene Clusters for VAV2:

Vav 2 guanine nucleotide exchange factor

Hs.369921 [show with all ESTs], Hs.689325

Unigene Representative Sequences: NM_001134398, AK130575

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000371846 ENST00000325440 ENST00000406606 ENST00000343203 ENST00000371850 ENST00000371851

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VAV2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VAV2

¹ / ² / ³

9 probe-sets matching VAV2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52054_at²^{, 3}	U95-B	1	1.00	1.00	0.86	1.01	AI434780	0.40	1.00	0.76	1
1704_at²^{, 3}	U95-A	1	1.00	1.00	0.49	0.65	S76992	1.00	1.00	1.00	1
62761_i_at²^{, 3}	U95-C	15	0.31	0.07	-0.22	1.39	T74260	0.20	0.10	0.16	1
205537_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003371	0.60	1.00	0.82	1
226063_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA481141	0.60	1.00	0.82	1
205536_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_003371	0.60	1.00	0.82	1
205537_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226063_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205536_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks VAV2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCCTTTCCA

SOURCE GeneReport for Unigene clusters: Hs.369921 Hs.689325
Expression variation in blood from EXPOLDB for VAV2
UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VAV2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAV2¹	--	vav 2 guanine nucleotide exchange factor	89.84(n) 95.01(a)	608060 XM_844947.1 XP_850040.1
rat (Rattus norvegicus)	Vav2¹	--	vav 2 guanine nucleotide exchange factor	88.36(n) 95.11(a)	296603 XM_216030.4 XP_216030.4
mouse (Mus musculus)	Vav2^{1, 5}	2 (15.30 cM)⁵	vav 2 oncogene^{1, 5}	88.24(n)¹ 95.95(a)¹	22325¹ NM_009500.1¹ NP_033526.1¹ AI847175⁵ AK012893⁵ (see all 11)
chicken (Gallus gallus)	VAV2¹	--	vav 2 guanine nucleotide exchange factor	83.47(n) 91.78(a)	373938 NM_204142.1 NP_989473.1
fruit fly (Drosophila melanogaster)	vav³	18B6--7	Rho protein signal transduction guanyl-nucleotide more	28(a)	--

About this table Species with no ortholog for VAV2

ENSEMBL Gene Tree for VAV2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for VAV2 gene

VAV1² TIAM2² VAV3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/2062 NCBI SNPs in VAV2 are shown (see all 2062 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 722)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs642193^1,2	A,C,F,H	135616727(+)	`TGCTGA/CGGTTG`	1	--	ng5¹		9		EA EU WA NA	2260
	rs602990^1,2	A,C,F,H	135633815(+)	`CTGCAT/CGGCCA`	2	V/M	mis¹		11		MN EU EA WA NA	1206
	rs509590^1,2	A,C,F	135618591(-)	`CCCCCG/ACACCC`	2	--	ut3¹ ese³		1		MN	184
--	rs10993795^1,2	C,F,H	135618736(+)	`GCAGCG/ACTGTC`	2	--	ut3¹ ese³		4		EU EA WA	420
	rs13299267^1,2	A	135616931(+)	`TTCCCA/GCCAGC`	2	--	ut3¹		0	--	--	--	--
	rs1043077^1,2	F	135618042(-)	`TCCAGC/TCCCTG`	2	--	ut3¹		1		MN	184
	rs9722384^1,2	A,C,F,H	135623427(+)	`CCGCCG/AATGCG`	2	I/I	syn¹ ese³		4		EU EA WA	410
	rs7865299^1,2	C,F,H	135652749(+)	`ATCAGA/GAGCCT`	2	L/L	syn¹		8		EU EA WA	834
	rs2519109^1,2	A,C,F,H,O	135797591(+)	`TACACG/AGATCC`	1	--	int¹		21		NS EA EU WA NA	2962
	rs2486341^1,2	A,C,F,H,O	135680321(+)	`CCTTCA/CGACCA`	1	--	int¹		7		EU EA WA NA	556

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HapMap Linkage Disequilibrium images for VAV2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600428

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/67 PubMed articles for VAV2 gene (see all 67 ):

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. (PubMed id 7762982)^{2, 3, 4} Henske E.P.... Kwiatkowski D.J. (1995)
Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. (PubMed id 12454019)^{1, 3, 4} Tamas P.... Buday L. (2003)
Vav2 is required for cell spreading. (PubMed id 11448999)^{1, 3} Marignani P.A. and Carpenter C.L. (2001)
Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor. (PubMed id 11516622)^{1, 3} Tamas P....Buday L. (2001)
Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. (PubMed id 11262396)^{1, 3} Tartare-Deckert S....Deckert M. (2001)
Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. (PubMed id 11080163)^{1, 3} Doody G.M....Turner M. (2000)
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. (PubMed id 10982832)^{1, 3} Liu B.P. and Burridge K. (2000)
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)^{1, 3} Miller S.L....Clevenger C.V. (2005)
Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. (PubMed id 11909943)^{1, 3} Booden M.A....Der C.J. (2002)
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. (PubMed id 10618391)^{1, 3} Pandey A....Lodish H.F. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7410	HGNC: 12658	AceView: VAV2.1	Ensembl:ENSG00000160293	euGenes: HUgn7410
ECgene: VAV2	H-InvDB: VAV2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for VAV2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for VAV2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VAV2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VAV2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VAV2		Antibodies for VAV2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VAV2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Antibodies (Vav proteins, VAV2)

Search OriGene for VAV2

Search Tocris compounds for VAV2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VAV2

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VAV2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VAV2

Summaries
for VAV2

Genomic Location
for VAV2

Proteins
for VAV2

Protein Domains/
Families
for VAV2

Gene Function
for VAV2

Pathways & Interactions
for VAV2

Drugs & Compounds
for VAV2

Transcripts
for VAV2

Expression
for VAV2

Orthologs
for VAV2

Paralogs
for VAV2

SNPs/Variants
for VAV2

Disorders & Mutations
for VAV2

Medical News
for VAV2

Publications
for VAV2

Search for VAV2

Genome Databases showing VAV2

Other Databases showing VAV2

Specialized Databases showing VAV2

Licensable Technologies
for VAV2

Services
for VAV2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VAV2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VAV2

Summariesfor VAV2

Genomic Locationfor VAV2

Proteinsfor VAV2

Protein Domains/Familiesfor VAV2

Gene Functionfor VAV2

Pathways & Interactionsfor VAV2

Drugs & Compoundsfor VAV2

Transcriptsfor VAV2

Expression for VAV2

Orthologsfor VAV2

Paralogsfor VAV2

SNPs/Variantsfor VAV2

Disorders & Mutationsfor VAV2

Medical Newsfor VAV2

Publicationsfor VAV2

Search for VAV2

Genome Databases showing VAV2

Other Databases showing VAV2

Specialized Databases showing VAV2

Licensable Technologiesfor VAV2

Servicesfor VAV2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VAV2

Summaries
for VAV2

Genomic Location
for VAV2

Proteins
for VAV2

Protein Domains/
Families
for VAV2

Gene Function
for VAV2

Pathways & Interactions
for VAV2

Drugs & Compounds
for VAV2

Transcripts
for VAV2

Expression
for VAV2

Orthologs
for VAV2

Paralogs
for VAV2

SNPs/Variants
for VAV2

Disorders & Mutations
for VAV2

Medical News
for VAV2

Publications
for VAV2

Licensable Technologies
for VAV2

Services
for VAV2