Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VAV2 Gene

Aliases for VAV2 Gene

  • Vav Guanine Nucleotide Exchange Factor 2 2 3 5
  • Vav 2 Guanine Nucleotide Exchange Factor 2 3
  • Vav 2 Oncogene 2 3
  • VAV-2 3 4

External Ids for VAV2 Gene

Previous GeneCards Identifiers for VAV2 Gene

  • GC09M127703
  • GC09M128297
  • GC09M130051
  • GC09M131970
  • GC09M131968
  • GC09M133657
  • GC09M135616
  • GC09M136627
  • GC09M106127

Summaries for VAV2 Gene

Entrez Gene Summary for VAV2 Gene

  • VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for VAV2 Gene

VAV2 (Vav Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with VAV2 include Glaucoma, Normal Tension. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and EphB-EphrinB Signaling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and epidermal growth factor receptor binding. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot for VAV2 Gene

  • Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Gene Wiki entry for VAV2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV2 Gene

Genomics for VAV2 Gene

Regulatory Elements for VAV2 Gene

Enhancers for VAV2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VAV2 on UCSC Golden Path with GeneCards custom track

Promoters for VAV2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAV2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAV2 Gene

Chromosome:
9
Start:
133,761,894 bp from pter
End:
133,992,604 bp from pter
Size:
230,711 bases
Orientation:
Minus strand

Genomic View for VAV2 Gene

Genes around VAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV2 Gene

Proteins for VAV2 Gene

  • Protein details for VAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52735-VAV2_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor VAV2
    Protein Accession:
    P52735
    Secondary Accessions:
    • A2RUM4
    • A8MQ12
    • B6ZDF5
    • Q5SYV3
    • Q5SYV4
    • Q5SYV5
    • Q6N012
    • Q6PIJ9
    • Q6Q317

    Protein attributes for VAV2 Gene

    Size:
    878 amino acids
    Molecular mass:
    101289 Da
    Quaternary structure:
    • Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

    Three dimensional structures from OCA and Proteopedia for VAV2 Gene

    Alternative splice isoforms for VAV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV2 Gene

Proteomics data for VAV2 Gene at MOPED

Post-translational modifications for VAV2 Gene

  • Phosphorylated on tyrosine residues in response to FGR activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAV2 Gene

No data available for DME Specific Peptides for VAV2 Gene

Domains & Families for VAV2 Gene

Suggested Antigen Peptide Sequences for VAV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52735

UniProtKB/Swiss-Prot:

VAV2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with VAV2: view

Function for VAV2 Gene

Molecular function for VAV2 Gene

GENATLAS Biochemistry:
VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same region
UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
genes like me logo Genes that share phenotypes with VAV2: view

Animal Models for VAV2 Gene

MGI Knock Outs for VAV2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV2 Gene

Localization for VAV2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAV2 Gene COMPARTMENTS Subcellular localization image for VAV2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VAV2 Gene

Pathways & Interactions for VAV2 Gene

genes like me logo Genes that share pathways with VAV2: view

SIGNOR curated interactions for VAV2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 7762982
GO:0007411 axon guidance TAS --
GO:0008361 NOT regulation of cell size IGI 22467863
GO:0010468 regulation of gene expression IMP 21810271
genes like me logo Genes that share ontologies with VAV2: view

Drugs & Compounds for VAV2 Gene

(6) Drugs for VAV2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(7) Additional Compounds for VAV2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with VAV2: view

Transcripts for VAV2 Gene

mRNA/cDNA for VAV2 Gene

(6) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for VAV2 Gene

No ASD Table

Relevant External Links for VAV2 Gene

GeneLoc Exon Structure for
VAV2
ECgene alternative splicing isoforms for
VAV2

Expression for VAV2 Gene

mRNA expression in normal human tissues for VAV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV2 Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for VAV2 Gene

This gene is overexpressed in Lymph node (28.7) and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAV2 Gene



SOURCE GeneReport for Unigene cluster for VAV2 Gene Hs.369921

mRNA Expression by UniProt/SwissProt for VAV2 Gene

P52735-VAV2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with VAV2: view

Protein tissue co-expression partners for VAV2 Gene

Primer Products

Orthologs for VAV2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAV2 35
  • 90.31 (n)
  • 93.87 (a)
VAV2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAV2 35
  • 90.27 (n)
  • 95.87 (a)
VAV2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vav2 35
  • 88.4 (n)
  • 95.85 (a)
Vav2 16
Vav2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAV2 35
  • 99.08 (n)
  • 99.89 (a)
VAV2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vav2 35
  • 88.56 (n)
  • 95.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves VAV2 35
  • 83.23 (n)
  • 91.66 (a)
VAV2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAV2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC733982 35
  • 76.62 (n)
  • 83.33 (a)
Str.6889 35
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-116h7.3 35
  • 76.62 (n)
  • 81.78 (a)
VAV2 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vav 37
  • 28 (a)
vav 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vav-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 36
  • 37 (a)
OneToMany
Species with no ortholog for VAV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV2 Gene

ENSEMBL:
Gene Tree for VAV2 (if available)
TreeFam:
Gene Tree for VAV2 (if available)

Paralogs for VAV2 Gene

Paralogs for VAV2 Gene

(5) SIMAP similar genes for VAV2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VAV2: view

Variants for VAV2 Gene

Sequence variations from dbSNP and Humsavar for VAV2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs602990 - 133,778,872(+) CTGCA(C/T)GGCCA reference, missense
rs635277 -- 133,957,058(-) GCGTT(C/G)GAGAG intron-variant
rs635323 -- 133,957,088(-) ACAGA(A/G)TGAGG intron-variant
rs635739 -- 133,957,180(-) GGCCC(A/G)TAACT intron-variant
rs636541 -- 133,950,433(-) CTGAG(A/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAV2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894081 CNV Loss 21882294
nsv894086 CNV Gain 21882294
nsv894114 CNV Loss 21882294
nsv482984 CNV Gain 15286789
dgv95n68 CNV Loss 17160897
nsv894117 CNV Loss 21882294
nsv466622 CNV Gain 19166990
dgv8334n71 CNV Loss 21882294
dgv8335n71 CNV Loss 21882294
nsv894122 CNV Loss 21882294
esv2739180 CNV Deletion 23290073
esv2739181 CNV Deletion 23290073
esv1173174 CNV Insertion 17803354
esv23592 CNV Loss 19812545
nsv894123 CNV Loss 21882294
esv2558146 CNV Deletion 19546169
esv1008803 CNV Deletion 20482838
esv2089947 CNV Deletion 18987734
nsv512125 CNV Loss 21212237
esv2075786 CNV Deletion 18987734
esv2739182 CNV Deletion 23290073
esv29560 CNV Gain 19812545
dgv1327e201 CNV Deletion 23290073
dgv1328e201 CNV Deletion 23290073
esv1659384 CNV Deletion 17803354
esv1759403 CNV Deletion 17803354
esv9620 CNV Loss 19470904
nsv894124 CNV Gain 21882294
nsv894125 CNV Loss 21882294
nsv6750 CNV Insertion 18451855
dgv8336n71 CNV Loss 21882294
nsv894127 CNV Loss 21882294
dgv8337n71 CNV Loss 21882294
nsv466623 CNV Loss 19166990
esv21707 CNV Gain 19812545
nsv821593 CNV Deletion 20802225
nsv437652 CNV Loss 16327808
nsv466624 CNV Loss 19166990
esv2484363 CNV Deletion 19546169
nsv523970 CNV Loss 19592680
esv2142197 CNV Deletion 18987734
esv2739189 CNV Deletion 23290073
esv2666453 CNV Deletion 23128226
esv1105871 CNV Deletion 17803354
esv2673211 CNV Deletion 23128226
nsv521178 CNV Loss 19592680
nsv466625 CNV Loss 19166990
esv2739190 CNV Deletion 23290073
esv2739191 CNV Deletion 23290073
nsv831748 CNV Loss 17160897
esv2739192 CNV Deletion 23290073
nsv466626 CNV Loss 19166990
nsv831749 CNV Loss 17160897
nsv894132 CNV Loss 21882294
esv2739193 CNV Deletion 23290073
nsv428226 CNV Loss 18775914
dgv8338n71 CNV Loss 21882294
dgv8339n71 CNV Loss 21882294
esv2739194 CNV Deletion 23290073
esv2739196 CNV Deletion 23290073
nsv825148 CNV Gain 20364138
esv26262 CNV Loss 19812545

Variation tolerance for VAV2 Gene

Residual Variation Intolerance Score: 7.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VAV2 Gene

Disorders for VAV2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VAV2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
glaucoma, normal tension
  • low tension glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search VAV2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAV2

Genetic Association Database (GAD)
VAV2
Human Genome Epidemiology (HuGE) Navigator
VAV2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAV2
genes like me logo Genes that share disorders with VAV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAV2 Gene

Publications for VAV2 Gene

  1. Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. (PMID: 7762982) Henske E.P. … Kwiatkowski D.J. (Ann. Hum. Genet. 1995) 2 3 4 67
  2. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. (PMID: 19826000) Duan L. … Band H. (J. Biol. Chem. 2010) 3 23
  3. VAV2 regulates epidermal growth factor receptor endocytosis and degradation. (PMID: 20140013) Thalappilly S. … Dusetti N.J. (Oncogene 2010) 3 23
  4. VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans. (PMID: 20140222) Fujikawa K. … Swat W. (PLoS ONE 2010) 3 23
  5. Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease. (PMID: 19451809) Holthusen K. … Meneses P.I. (Am J Ther 2009) 3 23

Products for VAV2 Gene

Sources for VAV2 Gene

Content