Aliases for VAV2 Gene
External Ids for VAV2 Gene
Previous GeneCards Identifiers for VAV2 Gene
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for VAV2 Gene
VAV2 (Vav 2 Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Diseases associated with VAV2 include glaucoma, normal tension and primary angle-closure glaucoma. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV3.
UniProtKB/Swiss-Prot for VAV2 Gene
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).