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Aliases for VAV2 Gene

Aliases for VAV2 Gene

  • Vav Guanine Nucleotide Exchange Factor 2 2 3 5
  • Vav 2 Guanine Nucleotide Exchange Factor 2 3
  • Vav 2 Oncogene 2 3
  • VAV-2 3 4
  • Guanine Nucleotide Exchange Factor VAV2 3

External Ids for VAV2 Gene

Previous GeneCards Identifiers for VAV2 Gene

  • GC09M127703
  • GC09M128297
  • GC09M130051
  • GC09M131970
  • GC09M131968
  • GC09M133657
  • GC09M135616
  • GC09M136627
  • GC09M106127

Summaries for VAV2 Gene

Entrez Gene Summary for VAV2 Gene

  • VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for VAV2 Gene

VAV2 (Vav Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with VAV2 include Glaucoma, Normal Tension and Agenesis Of The Corpus Callosum With Peripheral Neuropathy. Among its related pathways are p75 NTR receptor-mediated signalling and Innate Immune System. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and epidermal growth factor receptor binding. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot for VAV2 Gene

  • Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Gene Wiki entry for VAV2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV2 Gene

Genomics for VAV2 Gene

Regulatory Elements for VAV2 Gene

Enhancers for VAV2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G133792 1.2 Ensembl ENCODE 26.9 +199.3 199321 1.0 HDGF CBX3 TBL1XR1 RB1 ARID4B SIN3A NFXL1 ZNF2 ZNF48 RAD21 VAV2 SARDH DBH GC09P133784 GC09M133930
GH09G133953 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +36.7 36703 4.1 HDGF TBP PKNOX1 ZFP64 NFXL1 GLIS2 EGR1 RELB IKZF2 CREM VAV2 BRD3 SARDH GC09P133952 GC09P133983
GH09G133785 1.1 Ensembl ENCODE 22.9 +204.3 204281 4.7 ARID4B YBX1 RAD21 EGR1 IKZF2 CREM EGR2 CBFB CEBPB GATAD2B VAV2 SARDH GC09P133784 GC09M133930
GH09G133825 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +166.4 166380 1.8 KLF1 SREBF2 SIN3A KLF17 MAX CEBPG RAD21 ZIC2 YY1 POLR2A SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
GH09G133821 1.7 FANTOM5 ENCODE dbSUPER 11.3 +169.6 169606 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 ZNF207 KLF13 ZNF263 LINC00094 SLC2A6 VAV2 WDR5 REXO4 DBH RPL7A GC09P133784 GC09M133930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAV2 on UCSC Golden Path with GeneCards custom track

Promoters for VAV2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242690 404 2801 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for VAV2 Gene

Chromosome:
9
Start:
133,761,894 bp from pter
End:
133,992,604 bp from pter
Size:
230,711 bases
Orientation:
Minus strand

Genomic View for VAV2 Gene

Genes around VAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV2 Gene

Proteins for VAV2 Gene

  • Protein details for VAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52735-VAV2_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor VAV2
    Protein Accession:
    P52735
    Secondary Accessions:
    • A2RUM4
    • A8MQ12
    • B6ZDF5
    • Q5SYV3
    • Q5SYV4
    • Q5SYV5
    • Q6N012
    • Q6PIJ9
    • Q6Q317

    Protein attributes for VAV2 Gene

    Size:
    878 amino acids
    Molecular mass:
    101289 Da
    Quaternary structure:
    • Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

    Three dimensional structures from OCA and Proteopedia for VAV2 Gene

    Alternative splice isoforms for VAV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV2 Gene

Post-translational modifications for VAV2 Gene

  • Phosphorylated on tyrosine residues in response to FGR activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VAV2 Gene

Domains & Families for VAV2 Gene

Suggested Antigen Peptide Sequences for VAV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VAV2: view

No data available for UniProtKB/Swiss-Prot for VAV2 Gene

Function for VAV2 Gene

Molecular function for VAV2 Gene

GENATLAS Biochemistry:
VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same region
UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Gene Ontology (GO) - Molecular Function for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 11390470
genes like me logo Genes that share ontologies with VAV2: view
genes like me logo Genes that share phenotypes with VAV2: view

Animal Models for VAV2 Gene

MGI Knock Outs for VAV2:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VAV2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV2 Gene

Localization for VAV2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAV2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with VAV2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV2 Gene

Pathways & Interactions for VAV2 Gene

genes like me logo Genes that share pathways with VAV2: view

SIGNOR curated interactions for VAV2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 7762982
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008361 NOT regulation of cell size IGI 22467863
GO:0010468 regulation of gene expression IMP 21810271
genes like me logo Genes that share ontologies with VAV2: view

Drugs & Compounds for VAV2 Gene

(6) Drugs for VAV2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(7) Additional Compounds for VAV2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with VAV2: view

Transcripts for VAV2 Gene

mRNA/cDNA for VAV2 Gene

(9) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VAV2

Alternative Splicing Database (ASD) splice patterns (SP) for VAV2 Gene

No ASD Table

Relevant External Links for VAV2 Gene

GeneLoc Exon Structure for
VAV2
ECgene alternative splicing isoforms for
VAV2

Expression for VAV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV2 Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for VAV2 Gene

This gene is overexpressed in Lymph node (28.7) and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAV2 Gene



Protein tissue co-expression partners for VAV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VAV2 Gene:

VAV2

SOURCE GeneReport for Unigene cluster for VAV2 Gene:

Hs.369921

mRNA Expression by UniProt/SwissProt for VAV2 Gene:

P52735-VAV2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for VAV2 Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with VAV2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VAV2 Gene

Orthologs for VAV2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAV2 34 35
  • 99.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia VAV2 34 35
  • 90.31 (n)
dog
(Canis familiaris)
Mammalia VAV2 34 35
  • 90.27 (n)
rat
(Rattus norvegicus)
Mammalia Vav2 34
  • 88.56 (n)
mouse
(Mus musculus)
Mammalia Vav2 34 16 35
  • 88.4 (n)
chicken
(Gallus gallus)
Aves VAV2 34 35
  • 83.23 (n)
lizard
(Anolis carolinensis)
Reptilia VAV2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC733982 34
  • 76.62 (n)
Str.6889 34
zebrafish
(Danio rerio)
Actinopterygii VAV2 35
  • 81 (a)
OneToOne
si:dkeyp-116h7.3 34
  • 76.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta vav 36 35
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea vav-1 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 35
  • 37 (a)
OneToMany
Species where no ortholog for VAV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV2 Gene

ENSEMBL:
Gene Tree for VAV2 (if available)
TreeFam:
Gene Tree for VAV2 (if available)

Paralogs for VAV2 Gene

Paralogs for VAV2 Gene

(5) SIMAP similar genes for VAV2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VAV2: view

Variants for VAV2 Gene

Sequence variations from dbSNP and Humsavar for VAV2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000007348 -- 133,864,950(+) GTCTT(C/T)AGGTT intron-variant
rs1000023000 -- 133,832,144(+) TCTGA(A/C)CCTCT intron-variant
rs1000029667 -- 133,783,705(+) TCCCA(A/G)CACAC intron-variant
rs1000038170 -- 133,928,330(+) GAGGA(A/C)ATGTT