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VAV2 Gene

protein-coding   GIFtS: 66
GCID: GC09M136627

Vav 2 Guanine Nucleotide Exchange Factor

(Previous name: vav 2 oncogene)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vav 2 Guanine Nucleotide Exchange Factor1 2
Vav 2 Oncogene1 2
VAV-22 3
Guanine Nucleotide Exchange Factor VAV22

External Ids:    HGNC: 126581   Entrez Gene: 74102   Ensembl: ENSG000001602937   OMIM: 6004285   UniProtKB: P527353   

Export aliases for VAV2 gene to outside databases

Previous GC identifers: GC09M127703 GC09M128297 GC09M130051 GC09M131970 GC09M131968 GC09M133657 GC09M135616 GC09M106127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAV2 Gene:
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is
expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for VAV2 Gene:
VAV2 (vav 2 guanine nucleotide exchange factor) is a protein-coding gene. Diseases associated with VAV2 include primary angle-closure glaucoma, and primary open angle glaucoma. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV1.

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in
angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and
vascular endothelial cell migration and assembly (By similarity)

Gene Wiki entry for VAV2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAV2 gene promoter:
         SRF   AP-1   SRF (504 AA)   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VAV2 promoter sequence
   Search Chromatin IP Primers for VAV2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.1

VAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136627:  view genomic region     (about GC identifiers)

Start:
136,627,016 bp from pter      End:
136,857,726 bp from pter
Size:
230,711 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735 (See protein sequence)
Recommended Name: Guanine nucleotide exchange factor VAV2  
Size: 878 amino acids; 101289 Da
Subunit: Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity).
Interacts with NEK3 and PRLR and this interaction is prolactin-dependent
4 PDB 3D structures from and Proteopedia for VAV2:
2DLZ (3D)        2DM1 (3D)        2LNW (3D)        2LNX (3D)    
Secondary accessions: A2RUM4 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q5SYV5 Q6N012 Q6PIJ9 Q6Q317
Alternative splicing: 3 isoforms:  P52735-1   P52735-2   P52735-3   (Contains a phosphoserine at position 769)

Explore the universe of human proteins at neXtProt for VAV2: NX_P52735

Explore proteomics data for VAV2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues in response to FGR activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VAV2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127870.1  NP_003362.2  

    ENSEMBL proteins: 
     ENSP00000385362   ENSP00000360916   ENSP00000360917  
    Reactome Protein details: P52735

    VAV2 Human Recombinant Protein Products:

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    Novus Biologicals VAV2 Lysate
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    Abcam antibodies for VAV2 (Q9UKW4, P52735, P15498)
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    LSBio Antibodies in human, mouse, rat for VAV2

    VAV2 Assay Products:

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    Cloud-Clone Corp. ELISAs for VAV2
    Cloud-Clone Corp. CLIAs for VAV2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 10):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry P52735

    ProtoNet protein and cluster: P52735

    Selected Blocks protein domains (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    VAV2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAV2_HUMAN, P52735
    Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in
    angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and
    vascular endothelial cell migration and assembly (By similarity)

         Genatlas biochemistry entry for VAV2:
    VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same region

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding IPI11390470
    GO:0046872metal ion binding IEA--
         
    VAV2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAV2:
     Decreased focal adhesion (FA)  

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vav2):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  muscle  nervous system  renal/urinary system 
     vision/eye 

    VAV2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vav2tm1Tnr for VAV2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAV2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VAV2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAV2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAV2

    miRNA
    Products:
        
    miRTarBase miRNAs that target VAV2:
    hsa-let-7a-5p (MIRT052458), hsa-mir-877-3p (MIRT036995), hsa-mir-193b-3p (MIRT041420), hsa-mir-320a (MIRT044622), hsa-mir-155-5p (MIRT020809)

    Block miRNA regulation of human, mouse, rat VAV2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAV2 (see all 55):
    hsa-miR-513a-5p hsa-miR-106a hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-3921 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAV2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VAV2
    Predesigned siRNA for gene silencing in human, mouse, rat VAV2

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for VAV2 (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAV2 (NM_003371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV2

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    VAV2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAV2 About   (see all 61)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    3Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    Fc epsilon RI signaling pathway0.41
    4Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin Signaling Pathway0.39
    5Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VAV2 (see all 19)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PDGF Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for VAV2
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for VAV2 (see all 14)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development EGFR signaling via small GTPases
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response BCR pathway

    Selected BioSystems Pathways for VAV2 (see all 18)
        Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    BDNF signaling pathway
    Kit Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway

    Selected Reactome Pathways for VAV2 (see all 9)
        FCERI mediated MAPK activation
    G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle
    GPVI-mediated activation cascade


    Selected Kegg Pathways  (Kegg details for VAV2) (see all 11):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway


    VAV2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including VAV2: 
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VAV2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAV2 (P527351, 2, 3 ENSP000003609164) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-297549,EBI-641062 MINT-74801 MINT-74800 MINT-74802 I2D: score=2 STRING: ENSP00000269571
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-297549,EBI-375446 MINT-7908043 MINT-7908394 I2D: score=1 STRING: ENSP00000365312
    NEK3P519561, 3, ENSP000003832104EBI-297549,EBI-476041 I2D: score=2 STRING: ENSP00000383210
    SYKP434052, 3, ENSP000003648984MINT-7301412 I2D: score=2 STRING: ENSP00000364898
    TOM1L1O756741, 3, ENSP000004089584EBI-297549,EBI-712991 I2D: score=1 STRING: ENSP00000408958
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction TAS7762982
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    VAV2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAV2

    Selected HMDB Compounds for VAV2 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    6 Novoseek inferred chemical compound relationships for VAV2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61.9 39 11516622 (3), 10982832 (3), 15485841 (2), 16170364 (2) (see all 18)
    gtp 54 5 15485841 (1), 16170364 (1), 17996485 (1), 12411320 (1)
    phosphatidylinositol 30.9 6 12454019 (2), 16170364 (1), 12955089 (1), 18387945 (1)
    vegf 14.8 3 17686471 (3)
    calcium 0 5 11080163 (2)
    serine 0 2 15618286 (1)



    VAV2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VAV2 gene (2 alternative transcripts): 
    NM_001134398.1  NM_003371.3  

    Unigene Cluster for VAV2:

    Vav 2 guanine nucleotide exchange factor
    Hs.369921  [show with all ESTs]
    Unigene Representative Sequence: NM_001134398
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406606(uc004cet.1) ENST00000371850(uc004ces.3) ENST00000371851(uc004cer.3)
    ENST00000486113 ENST00000472905
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VAV2 (see all 55):
    hsa-miR-513a-5p hsa-miR-106a hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-3921 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAV2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VAV2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAV2 (NM_003371)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for VAV2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAV2
      QuantiTect SYBR Green Assays in human, mouse, rat VAV2
      QuantiFast Probe-based Assays in human, mouse, rat VAV2

    Additional mRNA sequence: 

    AJ420448.1 AK091622.1 AY563001.1 BC033187.1 BC043615.1 BC128448.1 BC132965.1 BC132967.1 
    BX640754.1 S76992.1 

    11 DOTS entries:

    DT.415120  DT.101968052  DT.100755376  DT.40296426  DT.95113897  DT.121156304  DT.91663125  DT.91758100 
    DT.91758101  DT.95306291  DT.100728201 

    1 AceView cDNA sequence:

    AK130575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAV2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACGAAGG
    VAV2 Expression
    About this image


    VAV2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    VAV2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAV2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369921

    UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including VAV2: 
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for VAV2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAV2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAV2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vav21 , 5 vav 2 oncogene1, 5 88.4(n)1
    95.85(a)1
      2 (19.36 cM)5
    223251  NM_009500.11  NP_033526.11 
     272621045 
    chicken
    (Gallus gallus)
    Aves VAV21 vav 2 guanine nucleotide exchange factor 83.23(n)
    91.66(a)
      373938  NM_204142.1  NP_989473.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAV26
    vav 2 guanine nucleotide exchange factor
    68(a)
    1 ↔ 1
    GL343736.1(84021-211228)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057726.12   -- 78.35(n)    BC057726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-116h7.31 si:dkeyp-116h7.3 76.62(n)
    81.78(a)
      556413  XM_002665976.2  XP_002666022.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta vav3 Rho protein signal transduction
    guanyl-nucleotide more
    28(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea vav-16
    Protein VAV-1, isoform b (vav-1) mRNA, complete cd...
    26(a)
    1 → many
    X(9216876-9232075) WBGene00006887
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC246
    Guanine nucleotide exchange factor (GEF or GDP-rel...
    16(a)
    1 → many
    I(62840-65404) YAL041W


    ENSEMBL Gene Tree for VAV2 (if available)
    TreeFam Gene Tree for VAV2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAV2 gene
    VAV12  VAV32  
    5 SIMAP similar genes for VAV2 using alignment to 1 protein entry:     VAV2_HUMAN:
    VAV3    SH3GL2    VAV1    CNN3    ITSN1

    VAV2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAV2 (see all 6678)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342504841,2
    C,F--136626519(+) CTCCCG/AAGAAG 2 -- ds50015Minor allele frequency- A:0.08NA 128
    rs353029401,2
    C--136626563(+) CTATTA/-AAAAA 2 -- ds50012Minor allele frequency- -:0.25NA 4
    rs1441837241,2
    --136626608(+) CCCAGA/GCGGGT 2 -- ds50010--------
    rs1506464911,2
    --136626609(+) CCAGGA/CGGGTC 2 -- ds50010--------
    rs1149119341,2
    C,F--136626610(+) CAGGCG/AGGTCT 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1816677581,2
    C--136626624(+) CTTCCC/TGGGCT 2 -- ds50010--------
    rs795619611,2
    F--136626759(+) GGTACC/ACAAGT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs357848371,2
    C,F--136626767(+) AGTGAT/CGGGGC 2 -- ds50016Minor allele frequency- C:0.08NA CSA EA 248
    rs1398047191,2
    --136626799(+) ATGCCC/TGATGC 2 -- ds50010--------
    rs1171598441,2
    F--136626800(+) TGCCCG/AATGCC 2 -- ds50011Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for VAV2 (136627016 - 136857726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VAV2 (see all 63):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739190CNV Deletion23290073
    esv2739192CNV Deletion23290073
    esv2089947CNV Deletion18987734
    esv1105871CNV Deletion17803354
    esv2739189CNV Deletion23290073
    esv2739191CNV Deletion23290073
    esv2075786CNV Deletion18987734
    esv2142197CNV Deletion18987734
    esv2558146CNV Deletion19546169
    esv1008803CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAV2
    DNA2.0 Custom Variant and Variant Library Synthesis for VAV2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600428    OMIM disorders: --

    16 diseases for VAV2:    
    About MalaCards
    primary angle-closure glaucoma    primary open angle glaucoma    tuberous sclerosis    open-angle glaucoma
    glaucoma    spasticity    oral squamous cell carcinoma    multiple sclerosis
    squamous cell carcinoma    pancreatic cancer    pancreatitis    melanoma
    endotheliitis    hiv-1    breast cancer    neuronitis


    VAV2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for VAV2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 11606575 (1), 19435813 (1)

    Genetic Association Database (GAD): VAV2
    Human Genome Epidemiology (HuGE) Navigator: VAV2 (4 documents)

    Export disorders for VAV2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAV2 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with VAV2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. (PubMed id 7762982)1, 2, 3 Henske E.P.... Kwiatkowski D.J. (Ann. Hum. Genet. 1995)
    2. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. (PubMed id 12454019)1, 2, 9 Tamas P.... Buday L. (J. Biol. Chem. 2003)
    3. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)1, 2, 9 Miller S.L.... Clevenger C.V. (Mol. Endocrinol. 2005)
    4. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PubMed id 21810271)1, 4 Antoni G....Tregouet D.A. (BMC Med. Genet. 2011)
    5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    6. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (PubMed id 20598377)1, 4 Nischwitz S....Weber F. (J. Neuroimmunol. 2010)
    7. Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population. (PubMed id 20463313)1, 4 Rao K.N....Chakrabarti S. (amp 2010)
    8. Vav2 is required for cell spreading. (PubMed id 11448999)1, 9 Marignani P.A. and Carpenter C.L. (J. Cell Biol. 2001)
    9. Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor. (PubMed id 11516622)1, 9 TamA!s P....Buday L. (Cell. Signal. 2001)
    10. Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. (PubMed id 11262396)1, 9 Tartare-Deckert S....Deckert M. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7410 HGNC: 12658 AceView: VAV2.1 Ensembl:ENSG00000160293 euGenes: HUgn7410
    ECgene: VAV2 Kegg: 7410 H-InvDB: VAV2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAV2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VAV2 gene:
    Search GeneIP for patents involving VAV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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