Aliases for VAV2 Gene
External Ids for VAV2 Gene
Previous GeneCards Identifiers for VAV2 Gene
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for VAV2 Gene
VAV2 (Vav Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with VAV2 include Glaucoma, Normal Tension and Agenesis Of The Corpus Callosum With Peripheral Neuropathy. Among its related pathways are Development EGFR signaling via small GTPases and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and epidermal growth factor receptor binding. An important paralog of this gene is VAV3.
UniProtKB/Swiss-Prot for VAV2 Gene
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).