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Aliases for VAV2 Gene

Aliases for VAV2 Gene

  • Vav Guanine Nucleotide Exchange Factor 2 2 3 5
  • Vav 2 Guanine Nucleotide Exchange Factor 2 3
  • Vav 2 Oncogene 2 3
  • VAV-2 3 4
  • Guanine Nucleotide Exchange Factor VAV2 3

External Ids for VAV2 Gene

Previous GeneCards Identifiers for VAV2 Gene

  • GC09M127703
  • GC09M128297
  • GC09M130051
  • GC09M131970
  • GC09M131968
  • GC09M133657
  • GC09M135616
  • GC09M136627
  • GC09M106127

Summaries for VAV2 Gene

Entrez Gene Summary for VAV2 Gene

  • VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for VAV2 Gene

VAV2 (Vav Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with VAV2 include Glaucoma, Normal Tension and Agenesis Of The Corpus Callosum With Peripheral Neuropathy. Among its related pathways are p75 NTR receptor-mediated signalling and Focal Adhesion. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and epidermal growth factor receptor binding. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot for VAV2 Gene

  • Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Gene Wiki entry for VAV2 Gene

Additional gene information for VAV2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV2 Gene

Genomics for VAV2 Gene

Regulatory Elements for VAV2 Gene

Enhancers for VAV2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H133953 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +36.7 36703 4.1 HDGF PKNOX1 ZFP64 SIN3A BATF GLIS2 ATF7 RCOR1 RUNX3 CREM VAV2 BRD3 SARDH GC09P133952 GC09P133983
GH09H133792 1.1 Ensembl ENCODE 26.9 +199.3 199321 1 HDGF TBL1XR1 RB1 ARID4B SIN3A ZNF2 RAD21 GLIS2 EGR1 ZNF366 VAV2 SARDH DBH GC09P133784 GC09M133930
GH09H133785 1.1 Ensembl ENCODE 22.9 +204.3 204281 4.7 TFAP4 SAP130 MAX ARID4B YBX1 RAD21 ZKSCAN1 POLR2A FOXK2 EED VAV2 SARDH GC09P133784 GC09M133930
GH09H133943 1.4 Ensembl ENCODE dbSUPER 12.3 +47.2 47208 3.8 PKNOX1 TBL1XR1 BMI1 BATF SCRT2 ZNF143 RCOR1 RUNX3 IKZF2 CREM ENSG00000273249 VAV2 GTF3C5 BRD3 GC09M133930 GC09P133952
GH09H133821 1.5 FANTOM5 ENCODE dbSUPER 11.3 +169.6 169606 3.8 HDGF PKNOX1 PTBP1 TBL1XR1 ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAV2 on UCSC Golden Path with GeneCards custom track

Promoters for VAV2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242690 404 2801 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Locations for VAV2 Gene

Genomic Locations for VAV2 Gene
230,711 bases
Minus strand

Genomic View for VAV2 Gene

Genes around VAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV2 Gene

Proteins for VAV2 Gene

  • Protein details for VAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide exchange factor VAV2
    Protein Accession:
    Secondary Accessions:
    • A2RUM4
    • A8MQ12
    • B6ZDF5
    • Q5SYV3
    • Q5SYV4
    • Q5SYV5
    • Q6N012
    • Q6PIJ9
    • Q6Q317

    Protein attributes for VAV2 Gene

    878 amino acids
    Molecular mass:
    101289 Da
    Quaternary structure:
    • Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

    Three dimensional structures from OCA and Proteopedia for VAV2 Gene

    Alternative splice isoforms for VAV2 Gene


neXtProt entry for VAV2 Gene

Post-translational modifications for VAV2 Gene

  • Phosphorylated on tyrosine residues in response to FGR activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VAV2 Gene

Domains & Families for VAV2 Gene

Suggested Antigen Peptide Sequences for VAV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VAV2: view

No data available for UniProtKB/Swiss-Prot for VAV2 Gene

Function for VAV2 Gene

Molecular function for VAV2 Gene

GENATLAS Biochemistry:
VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same region
UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Phenotypes From GWAS Catalog for VAV2 Gene

Gene Ontology (GO) - Molecular Function for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 11390470
genes like me logo Genes that share ontologies with VAV2: view
genes like me logo Genes that share phenotypes with VAV2: view

Animal Models for VAV2 Gene

MGI Knock Outs for VAV2:

Clone Products

  • Addgene plasmids for VAV2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV2 Gene

Localization for VAV2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAV2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
cytoskeleton 2
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with VAV2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV2 Gene

Pathways & Interactions for VAV2 Gene

genes like me logo Genes that share pathways with VAV2: view

SIGNOR curated interactions for VAV2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 7762982
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008361 NOT regulation of cell size IGI 22467863
GO:0010468 regulation of gene expression IMP 21810271
genes like me logo Genes that share ontologies with VAV2: view

Drugs & Compounds for VAV2 Gene

(6) Drugs for VAV2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(7) Additional Compounds for VAV2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with VAV2: view

Transcripts for VAV2 Gene

Clone Products

  • Addgene plasmids for VAV2

Alternative Splicing Database (ASD) splice patterns (SP) for VAV2 Gene

No ASD Table

Relevant External Links for VAV2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VAV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV2 Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for VAV2 Gene

This gene is overexpressed in Lymph node (28.7) and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAV2 Gene

Protein tissue co-expression partners for VAV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VAV2 Gene:


SOURCE GeneReport for Unigene cluster for VAV2 Gene:


mRNA Expression by UniProt/SwissProt for VAV2 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for VAV2 Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with VAV2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VAV2 Gene

Orthologs for VAV2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VAV2 33 34
  • 99.08 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
-- 34
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
-- 34
  • 92 (a)
-- 34
  • 67 (a)
-- 34
  • 62 (a)
(Bos Taurus)
Mammalia VAV2 33 34
  • 90.31 (n)
(Canis familiaris)
Mammalia VAV2 33 34
  • 90.27 (n)
(Rattus norvegicus)
Mammalia Vav2 33
  • 88.56 (n)
(Mus musculus)
Mammalia Vav2 33 16 34
  • 88.4 (n)
(Gallus gallus)
Aves VAV2 33 34
  • 83.23 (n)
(Anolis carolinensis)
Reptilia VAV2 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC733982 33
  • 76.62 (n)
Str.6889 33
(Danio rerio)
Actinopterygii VAV2 34
  • 81 (a)
si:dkeyp-116h7.3 33
  • 76.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta vav 35 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea vav-1 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 34
  • 37 (a)
Species where no ortholog for VAV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV2 Gene

Gene Tree for VAV2 (if available)
Gene Tree for VAV2 (if available)

Paralogs for VAV2 Gene

(5) SIMAP similar genes for VAV2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VAV2: view

Variants for VAV2 Gene

Sequence variations from dbSNP and Humsavar for VAV2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000007348 -- 133,864,950(+) GTCTT(C/T)AGGTT intron-variant
rs1000023000 -- 133,832,144(+) TCTGA(A/C)CCTCT intron-variant
rs1000029667 -- 133,783,705(+) TCCCA(A/G)CACAC intron-variant
rs1000038170 -- 133,928,330(+) GAGGA(A/C)ATGTT intron-variant
rs1000040348 -- 133,944,084(+) GCTTC(A/G)CCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAV2 Gene

Variant ID Type Subtype PubMed ID
nsv615735 CNV loss 21841781
nsv615737 CNV loss 21841781
nsv615738 CNV loss 21841781
nsv615741 CNV loss 21841781
nsv615742 CNV loss 21841781
nsv615743 CNV loss 21841781
nsv615744 CNV loss 21841781
nsv615750 CNV gain 21841781
nsv6750 CNV insertion 18451855
nsv821593 CNV deletion 20802225
nsv825148 CNV gain 20364138
nsv831748 CNV loss 17160897
nsv831749 CNV loss 17160897
nsv951802 CNV deletion 24416366
nsv951803 CNV deletion 24416366
nsv951804 CNV deletion 24416366
nsv615717 CNV loss 21841781
nsv615711 CNV gain 21841781
nsv615710 CNV loss 21841781
nsv615707 CNV loss 21841781
nsv615706 CNV gain 21841781
nsv615705 CNV loss 21841781
nsv615691 CNV gain 21841781
nsv523970 CNV loss 19592680
nsv521178 CNV loss 19592680
nsv512125 CNV loss 21212237
nsv482984 CNV gain 15286789
nsv466626 CNV loss 19166990
nsv466625 CNV loss 19166990
nsv466624 CNV loss 19166990
nsv466623 CNV loss 19166990
nsv466622 CNV gain 19166990
nsv437652 CNV loss 16327808
nsv428226 CNV loss 18775914
nsv1153973 CNV deletion 26484159
nsv1150401 CNV deletion 26484159
nsv1148680 CNV deletion 26484159
nsv1147963 CNV deletion 26484159
nsv1137673 CNV deletion 24896259
nsv1133744 CNV deletion 24896259
nsv1126925 CNV deletion 24896259
nsv1125319 OTHER inversion 24896259
nsv1124488 CNV deletion 24896259
nsv1124487 CNV deletion 24896259
nsv1120578 CNV tandem duplication 24896259
nsv1118375 CNV deletion 24896259
nsv1115246 CNV deletion 24896259
nsv1077192 CNV deletion 25765185
nsv1077191 CNV deletion 25765185
nsv1077190 CNV deletion 25765185
nsv1077189 CNV deletion 25765185
nsv1035272 CNV gain 25217958
esv9620 CNV loss 19470904
esv3621947 CNV loss 21293372
esv3621945 CNV loss 21293372
esv3621944 CNV loss 21293372
esv3576711 CNV gain 25503493
esv3545588 CNV deletion 23714750
esv3545586 CNV deletion 23714750
esv3545584 CNV deletion 23714750
esv3545582 CNV deletion 23714750
esv29560 CNV gain 19812545
esv2761297 CNV loss 21179565
esv2739196 CNV deletion 23290073
esv2739194 CNV deletion 23290073
esv2739193 CNV deletion 23290073
esv2739192 CNV deletion 23290073
esv2739191 CNV deletion 23290073
esv2739190 CNV deletion 23290073
esv2739189 CNV deletion 23290073
esv2739182 CNV deletion 23290073
esv2739181 CNV deletion 23290073
esv2739180 CNV deletion 23290073
esv2739138 CNV deletion 23290073
esv2673211 CNV deletion 23128226
esv2666453 CNV deletion 23128226
esv26262 CNV loss 19812545
esv2558146 CNV deletion 19546169
esv2484363 CNV deletion 19546169
esv23592 CNV loss 19812545
esv21707 CNV gain 19812545
esv2142197 CNV deletion 18987734
esv2089947 CNV deletion 18987734
esv2075786 CNV deletion 18987734
esv1759403 CNV deletion 17803354
esv1659384 CNV deletion 17803354
esv1173174 CNV insertion 17803354
esv1105871 CNV deletion 17803354
esv1008803 CNV deletion 20482838
dgv95n68 CNV loss 17160897
dgv4159n106 CNV deletion 24896259
dgv2186e212 CNV loss 25503493
dgv12964n54 CNV loss 21841781
dgv12963n54 CNV gain 21841781
dgv12962n54 CNV gain 21841781
dgv12961n54 CNV gain 21841781
dgv12960n54 CNV loss 21841781
dgv12959n54 CNV gain+loss 21841781
dgv12958n54 CNV loss 21841781
dgv12957n54 CNV loss 21841781
dgv12956n54 CNV loss 21841781
dgv12955n54 CNV loss 21841781
dgv12954n54 CNV loss 21841781
dgv12953n54 CNV gain 21841781
dgv12952n54 CNV gain+loss 21841781
dgv12951n54 CNV gain 21841781
dgv12950n54 CNV gain+loss 21841781
dgv12949n54 CNV gain 21841781
dgv1270e201 CNV deletion 23290073
dgv1269e201 CNV deletion 23290073

Variation tolerance for VAV2 Gene

Residual Variation Intolerance Score: 7.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAV2 Gene

Disorders for VAV2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for VAV2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glaucoma, normal tension
  • low tension glaucoma
agenesis of the corpus callosum with peripheral neuropathy
  • hereditary motor and sensory neuropathy with agenesis of the corpus callosum
- elite association - COSMIC cancer census association via MalaCards
Search VAV2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAV2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VAV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAV2 Gene

Publications for VAV2 Gene

  1. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PMID: 15618286) Miller SL … Clevenger CV (Molecular endocrinology (Baltimore, Md.) 2005) 3 4 22 60
  2. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. (PMID: 12454019) Tamás P … Buday L (The Journal of biological chemistry 2003) 3 4 22 60
  3. Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. (PMID: 7762982) Henske EP … Kwiatkowski DJ (Annals of human genetics 1995) 2 3 4 60
  4. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G … Tregouet DA (BMC medical genetics 2011) 3 45 60
  5. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. (PMID: 19826000) Duan L … Band H (The Journal of biological chemistry 2010) 3 22 60

Products for VAV2 Gene

Sources for VAV2 Gene