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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAV2 Gene

protein-coding   GIFtS: 65
GCID: GC09M136627

Vav 2 Guanine Nucleotide Exchange Factor

(Previous name: vav 2 oncogene)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vav 2 Guanine Nucleotide Exchange Factor1 2
Vav 2 Oncogene1 2
VAV-22 3
Guanine Nucleotide Exchange Factor VAV22

External Ids:    HGNC: 126581   Entrez Gene: 74102   Ensembl: ENSG000001602937   OMIM: 6004285   UniProtKB: P527353   

Export aliases for VAV2 gene to outside databases

Previous GC identifers: GC09M127703 GC09M128297 GC09M130051 GC09M131970 GC09M131968 GC09M133657 GC09M135616 GC09M106127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAV2 Gene:
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is
expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for VAV2 Gene: 
VAV2 (vav 2 guanine nucleotide exchange factor) is a protein-coding gene. Diseases associated with VAV2 include primary angle-closure glaucoma, and glaucoma, and among its related super-pathways are Immune response Fc epsilon RI pathway and BCR signaling pathway. GO annotations related to this gene include epidermal growth factor receptor binding and phospholipid binding. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in
angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and
vascular endothelial cell migration and assembly (By similarity)

Gene Wiki entry for VAV2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAV2 gene promoter:
         SRF   AP-1   SRF (504 AA)   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VAV2 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAV2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.1

VAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136627:  view genomic region     (about GC identifiers)

Start:
136,627,016 bp from pter      End:
136,857,726 bp from pter
Size:
230,711 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735 (See protein sequence)
Recommended Name: Guanine nucleotide exchange factor VAV2  
Size: 878 amino acids; 101289 Da
Subunit: Interacts (via SH2 domains) with the phosphorylated form of EPHA2 (By similarity). Interacts with NEK3
and PRLR and this interaction is prolactin-dependent
4 PDB 3D structures from and Proteopedia for VAV2:
2DLZ (3D)        2DM1 (3D)        2LNW (3D)        2LNX (3D)    
Secondary accessions: A2RUM4 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q5SYV5 Q6N012 Q6PIJ9 Q6Q317
Alternative splicing: 3 isoforms:  P52735-1   P52735-2   P52735-3   (Contains a phosphoserine at position 769)

Explore the universe of human proteins at neXtProt for VAV2: NX_P52735

Explore proteomics data for VAV2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues in response to FGR activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52735

  • VAV2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VAV2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001127870.1  NP_003362.2  

    ENSEMBL proteins: 
     ENSP00000385362   ENSP00000360916   ENSP00000360917  
    Reactome Protein details: P52735
    Human Recombinant Protein Products for VAV2: 
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    Novus Biologicals VAV2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VAV2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    VAV2 for ontologies           About GeneDecksing



    VAV2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for VAV2 

    Assay Products for VAV2: 
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    Cloud-Clone Corp. ELISAs for VAV2 
    Cloud-Clone Corp. CLIAs for VAV2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    5/9 InterPro protein domains (see all 9):
     IPR011511 SH3_2
     IPR001331 GDS_CDC24_CS
     IPR001715 CH-domain
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P52735

    ProtoNet protein and cluster: P52735

    5/6 Blocks protein domains (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    VAV2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAV2_HUMAN, P52735
    Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in
    angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and
    vascular endothelial cell migration and assembly (By similarity)

         Genatlas biochemistry entry for VAV2:
    VAV proto-oncogene 2,homolog,widely expressed with duplicated exons or pseudogene(s),in the same region

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding IPI11390470
    GO:0005543phospholipid binding IEA--
         
    VAV2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAV2:
     Decreased focal adhesion (FA)  

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vav2):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  muscle  nervous system  renal/urinary system 
     vision/eye 

    VAV2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vav2tm1Tnr for VAV2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VAV2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VAV2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAV2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAV2 

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate VAV2 (see all 55):
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    SwitchGear 3'UTR luciferase reporter plasmidVAV2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAV2 (NM_003371)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAV2 About   (see all 59)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.45
    Immune response Role of DAP12 receptors in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    2B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    3Focal Adhesion
    Focal adhesion0.64
    Integrin-mediated cell adhesion0.38
    4Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Prolactin Signaling Pathway0.39
    5PKC-Theta Pathway
    TCR Signaling0.68
    Fc-EpsilonRI Pathway0.49
    PKC-Theta Pathway0.68
    PDGF Pathway0.39
    ITK and TCR Signaling0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/14 EMD Millipore Pathways for VAV2 (see all 14)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development PDGF signaling via MAPK cascades
    Immune response Role of DAP12 receptors in NK cells
    Cytoskeleton remodeling Role of PDGFs in cell migration

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VAV2 (see all 19)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PDGF Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for VAV2
        Cytoskeletal Signaling

    5/14 GeneGo (Thomson Reuters) Pathways for VAV2 (see all 14)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development EGFR signaling via small GTPases
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response BCR pathway

    5/18 BioSystems Pathways for VAV2 (see all 18)
        EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    BDNF signaling pathway
    Kit Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway

    5/26        Reactome Pathways for VAV2 (see all 26)
        L1CAM interactions
    Developmental Biology
    FCERI mediated MAPK activation
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE


    5/10         Kegg Pathways  (Kegg details for VAV2) (see all 10):
        Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway


    VAV2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAV2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/190 Interacting proteins for VAV2 (P527351, 2, 3 ENSP000003609164) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74801 MINT-74800 MINT-74802 I2D: score=2 STRING: ENSP00000269571
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908043 MINT-7908394 I2D: score=1 STRING: ENSP00000365312
    NEK3P519561, 3, ENSP000003832104EBI-297549,EBI-476041 I2D: score=2 STRING: ENSP00000383210
    SYKP434052, 3, ENSP000003648984MINT-7301412 I2D: score=2 STRING: ENSP00000364898
    TOM1L1O756741, 3, ENSP000004089584EBI-297549,EBI-712991 I2D: score=1 STRING: ENSP00000408958
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction TAS7762982
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    VAV2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAV2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAV2

    10/846 HMDB Compounds for VAV2 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    6 Novoseek inferred chemical compound relationships for VAV2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61.9 39 11516622 (3), 10982832 (3), 15485841 (2), 16170364 (2) (see all 18)
    gtp 54 5 15485841 (1), 16170364 (1), 17996485 (1), 12411320 (1)
    phosphatidylinositol 30.9 6 12454019 (2), 16170364 (1), 12955089 (1), 18387945 (1)
    vegf 14.8 3 17686471 (3)
    calcium 0 5 11080163 (2)
    serine 0 2 15618286 (1)

    Search CenterWatch for drugs/clinical trials and news about VAV2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAV2 gene (2 alternative transcripts): 
    NM_001134398.1  NM_003371.3  

    Unigene Clusters for VAV2:

    Vav 2 guanine nucleotide exchange factor
    Hs.369921  [show with all ESTs], Hs.689325
    Unigene Representative Sequences: NM_001134398, AK130575
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406606(uc004cet.1) ENST00000371850(uc004ces.3) ENST00000371851(uc004cer.3)
    ENST00000486113 ENST00000472905
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV2
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAV2

    Additional mRNA sequence: AK130575.1 

    11 DOTS entries:

    DT.415120  DT.101968052  DT.100755376  DT.40296426  DT.95113897  DT.121156304  DT.91663125  DT.91758100 
    DT.91758101  DT.95306291  DT.100728201 

    1 AceView cDNA sequence:

    AK130575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAV2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACGAAGG
    VAV2 Expression
    About this image


    See VAV2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAV2

    SOURCE GeneReport for Unigene clusters: Hs.369921 Hs.689325

    UniProtKB/Swiss-Prot: VAV2_HUMAN, P52735
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including VAV2: 
              Focal Adhesions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAV2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vav21 , 5 vav 2 oncogene1, 5 88.4(n)1
    95.85(a)1
      2 (19.36 cM)5
    223251  NM_009500.11  NP_033526.11 
     272621045 
    chicken
    (Gallus gallus)
    Aves VAV21 vav 2 guanine nucleotide exchange factor 83.51(n)
    91.78(a)
      373938  NM_204142.1  NP_989473.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAV26
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343736.1(84021-211228)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057726.12   -- 78.35(n)    BC057726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vav21 vav 2 guanine nucleotide exchange factor 77.05(n)
    82.29(a)
      556413  XM_002665976.1  XP_002666022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vav3 Rho protein signal transduction
    guanyl-nucleotide more
    28(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea vav-16
    cgef-26
    Protein CGEF-2
    26(a)
    11(a)
    1 ↔ many
    possible ortholog
    X(9216876-9232075)
    I(4409689-4426176)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC246
    Guanine nucleotide exchange factor (GEF or GDP-rel...
    12(a)
    1 → many
    I(62840-65404)


    ENSEMBL Gene Tree for VAV2 (if available)
    TreeFam Gene Tree for VAV2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAV2 gene
    ARHGEF62  VAV12  PLEKHG22  PLEKHG32  PREX22  ARHGEF72  TIAM12  SPATA132  
    TIAM22  ARHGEF92  VAV32  ARHGEF42  PREX12  PLEKHG12  
    5 SIMAP similar genes for VAV2 using alignment to 1 protein entry:     VAV2_HUMAN:
    VAV3    SH3GL2    VAV1    CNN3    ITSN1

    VAV2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6678 SNPs in VAV2 are shown (see all 6678)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342504841,2
    C,F--136626519(+) CTCCCG/AAGAAG 2 -- ds50015Minor allele frequency- A:0.08NA 128
    rs353029401,2
    C--136626563(+) CTATTA/-AAAAA 2 -- ds50012Minor allele frequency- -:0.25NA 4
    rs1441837241,2
    --136626608(+) CCCAGA/GCGGGT 2 -- ds50010--------
    rs1506464911,2
    --136626609(+) CCAGGA/CGGGTC 2 -- ds50010--------
    rs1149119341,2
    C,F--136626610(+) CAGGCG/AGGTCT 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1816677581,2
    C--136626624(+) CTTCCC/TGGGCT 2 -- ds50010--------
    rs795619611,2
    F--136626759(+) GGTACC/ACAAGT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs357848371,2
    C,F--136626767(+) AGTGAT/CGGGGC 2 -- ds50016Minor allele frequency- C:0.08NA CSA EA 248
    rs1398047191,2
    --136626799(+) ATGCCC/TGATGC 2 -- ds50010--------
    rs1171598441,2
    F--136626800(+) TGCCCG/AATGCC 2 -- ds50011Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for VAV2 (136627016 - 136857726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/63 variations for VAV2 (see all 63):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739190CNV Deletion23290073
    esv2739192CNV Deletion23290073
    esv2089947CNV Deletion18987734
    esv1105871CNV Deletion17803354
    esv2739189CNV Deletion23290073
    esv2739191CNV Deletion23290073
    esv2075786CNV Deletion18987734
    esv2142197CNV Deletion18987734
    esv2558146CNV Deletion19546169
    esv1008803CNV Deletion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600428    OMIM disorders: --

    13 diseases for VAV2:    About MalaCards
    primary angle-closure glaucoma    glaucoma    tuberous sclerosis    spasticity
    oral squamous cell carcinoma    multiple sclerosis    squamous cell carcinoma    pancreatic cancer
    pancreatitis    melanoma    endotheliitis    breast cancer
    neuronitis


    VAV2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for VAV2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 11606575 (1), 19435813 (1)

    Genetic Association Database (GAD): VAV2
    Human Genome Epidemiology (HuGE) Navigator: VAV2 (4 documents)

    Export disorders for VAV2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAV2 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with VAV2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. (PubMed id 7762982)1, 2, 3 Henske E.P.... Kwiatkowski D.J. (1995)
    2. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. (PubMed id 12454019)1, 2, 9 Tamas P.... Buday L. (2003)
    3. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)1, 2, 9 Miller S.L....Clevenger C.V. (2005)
    4. Combined analysis of three genome-wide association st udies on vWF and FVIII plasma levels. (PubMed id 21810271)1, 4 Antoni G....Tregouet D.A. (2011)
    5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    6. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (PubMed id 20598377)1, 4 Nischwitz S....Weber F. (2010)
    7. Variations in NTF4, VAV2, and VAV3 genes are not invo lved with primary open-angle and primary angle-closure glaucomas in an indian p opulation. (PubMed id 20463313)1, 4 Rao K.N....Chakrabarti S. (2010)
    8. Vav2 is required for cell spreading. (PubMed id 11448999)1, 9 Marignani P.A. and Carpenter C.L. (2001)
    9. Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor. (PubMed id 11516622)1, 9 Tamas P....Buday L. (2001)
    10. Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. (PubMed id 11262396)1, 9 Tartare-Deckert S....Deckert M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7410 HGNC: 12658 AceView: VAV2.1 Ensembl:ENSG00000160293 euGenes: HUgn7410
    ECgene: VAV2 Kegg: 7410 H-InvDB: VAV2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAV2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAV2 gene:
    Search GeneIP for patents involving VAV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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