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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAV1 Gene

protein-coding   GIFtS: 68
GCID: GC19P006772

vav 1 guanine nucleotide exchange factor

(Previous name: vav 1 oncogene )
(Previous symbol: VAV)
 Explore 29 diseases affiliated with
VAV1 via our new
 Human Malady Compendium 
Biological research products
for VAV1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Vav 1 Guanine Nucleotide Exchange Factor1 2
VAV1 2 3 5
Vav 1 Oncogene1 2
Proto-Oncogene Vav2

External Ids:    HGNC: 126571   Entrez Gene: 74092   Ensembl: ENSG000001419687   OMIM: 1648755   UniProtKB: P154983   

Export aliases for VAV1 gene to outside databases

Previous GC identifers: GC19P006867 GC19P006712 GC19P006723 GC19P006535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAV1:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho
family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.
The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The
encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and
binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK
signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
differentiation and/or proliferation

Gene Wiki entry for VAV1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAV1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VAV1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.2

VAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006772:  view genomic region     (about GC identifiers)

Start:
6,772,722 bp from pter      End:
6,857,371 bp from pter
Size:
84,650 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See protein sequence)
Recommended Name: Proto-oncogene vav  
Size: 845 amino acids; 98314 Da
Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and
ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a
B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and
down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2. Interacts with HCK (By
similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with
PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54 (By similarity)
Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet
Sequence caution: Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;
5 PDB 3D structures from and Proteopedia for VAV1:
2CRH (3D)        2LCT (3D)        2ROR (3D)        3BJI (3D)        3KY9 (3D)    
Secondary accessions: Q15860

Explore the universe of human proteins at neXtProt for VAV1: NX_P15498

Post-translational modifications:

  • Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).
  • Phosphorylated by FYN1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15498

  • VAV1 Protein expression data from MOPED and PaxDb:    About this image 
    VAV1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001245135.1  NP_001245136.1  NP_005419.2  

    ENSEMBL proteins: 
     ENSP00000302269   ENSP00000443242  
    Reactome Protein details: P15498
    Human Recombinant Protein Products for VAV1: 
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    Novus Biologicals VAV1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VAV1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    VAV1 for ontologies           About GeneDecksing



    VAV1 Antibody Products: 
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    Uscn ELISAs and CLIAs for VAV1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VAV1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001331 GDS_CDC24_CS
     IPR001715 CH-domain
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR003096 SM22_calponin

    Graphical View of Domain Structure for InterPro Entry P15498

    ProtoNet protein and cluster: P15498

    5/6 Blocks protein families (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Domain: The DH domain is involved in interaction with CCPG1 (By similarity)
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAV_HUMAN, P15498
    Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
    differentiation and/or proliferation

         Genatlas biochemistry entry for VAV1:
    VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the
    calcium,ERK and FNKB pathways

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2477241
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI18692475
    GO:0005543phospholipid binding IEA--
         
    VAV1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAV1:
     Increased S DNA content 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Vav1):
     cellular  digestive/alimentary  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  normal  reproductive system 

    VAV1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for VAV1: Vav1tm2Bbd Vav1tm1Tyb Vav1tm1Bbd
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VAV1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidVAV1 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/68 super-pathways (see all 68About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    PIP3 activates AKT signaling1.00
    PI3K/AKT activation0.97
    PI3K/AKT Signaling in Cancer1.00
    GAB1 signalosome0.96
    PI3K events in ERBB2 signaling1.00
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K events in ERBB4 signaling1.00
    Signaling by SCF-KIT0.72
    3Cell death signalling via NRAGE, NRIF and NADE
    Cell death signalling via NRAGE, NRIF and NADE1.00
    G alpha (12/13) signalling events0.39
    NRAGE signals death through JNK0.74
    Rho GTPase cycle0.25
    p75 NTR receptor-mediated signalling0.73
    Signaling by Rho GTPases0.25
    4PKC-Theta Pathway
    PKC-Theta Pathway1.00
    Fc-EpsilonRI Pathway0.42
    TCR Signaling0.68
    PDGF Pathway0.35
    ITK and TCR Signaling0.54
    5Development Angiotensin signaling via PYK2
    Development Angiotensin signaling via PYK21.00
    Development_EPO-induced MAPK pathway0.49
    Development_Angiotensin signaling via PYK20.98
    Development EPO-induced MAPK pathway0.49

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/20 EMD Millipore Pathways for VAV1 (see all 20)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Immune response Role of integrins in NK cells cytotoxicity
    Development Prolactin receptor signaling

    5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VAV1 (see all 20)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PDGF Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for VAV1
        Cytoskeletal Signaling

    5/20 GeneGo (Thomson Reuters) Pathways for VAV1 (see all 20)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    G-protein signaling Rac2 regulation pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD28 signaling

    5/20 BioSystems Pathways for VAV1 (see all 20
        Focal Adhesion
    EGFR1 Signaling Pathway
    IL-6 Signaling Pathway
    Kit Receptor Signaling Pathway
    IL-2 Signaling Pathway

    5/51        Reactome Pathways for VAV1 (see all 51)
        CD28 dependent Vav1 pathway
    Costimulation by the CD28 family
    G alpha (12/13) signalling events
    Signaling by EGFR in Cancer
    Downstream signal transduction


    5/9         Kegg Pathways  (Kegg details for VAV1) (see all 9):
        Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway


    VAV1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/192 Interacting proteins for VAV1 (P154981, 2, 3 ENSP000003022694) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8224277 MINT-8037411 MINT-8037350 MINT-8037380 MINT-8029621 I2D: score=7 STRING: ENSP00000046794
    SH3BP2P783142, 3, ENSP000003486854MINT-4563411 MINT-4549720 MINT-7301369 MINT-7301313 MINT-7301258 MINT-7301359 MINT-8026718 MINT-7301343 I2D: score=3 STRING: ENSP00000348685
    ZNF655Q8N7201, 2, 3, ENSP000003938764EBI-625518,EBI-741438 MINT-50591 MINT-50593 MINT-50590 I2D: score=3 STRING: ENSP00000393876
    ABL1P005192, 3, ENSP000003614234MINT-7226662 MINT-7226674 MINT-7226716 MINT-7226645 MINT-7226592 I2D: score=2 STRING: ENSP00000361423
    LCKP062392, 3, ENSP000003378254MINT-8028153 MINT-8224277 MINT-8025628 I2D: score=3 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS2477241
    GO:0006909phagocytosis ----
    GO:0006915apoptotic process TAS--
    GO:0006955immune response ----
    GO:0007229integrin-mediated signaling pathway ----

    VAV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAV1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for VAV1

    10/843 HMDB Compounds for VAV1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----
    10/37 Novoseek chemical compound relationships for VAV1 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.5 346 11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99)
    gdp 75.6 41 8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 26)
    gtp 65.5 39 8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26)
    phosphatidylinositol 61 22 9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16)
    phosphoinositide 53.6 20 11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12)
    guanine 50.8 12 12496381 (4), 20147552 (2), 19801678 (1), 9444953 (1) (see all 8)
    guanosine 49.6 5 9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1)
    piceatannol 39.1 1 11331248 (1)
    herbimycin a 36.4 5 8133029 (2), 8809042 (1)
    threonine 33.8 12 8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about VAV1 / VAV 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAV1 gene (3 alternative transcripts): 
    NM_001258206.1  NM_001258207.1  NM_005428.3  

    Unigene Cluster for VAV1:

    Vav 1 guanine nucleotide exchange factor
    Hs.116237  [show with all ESTs]
    Unigene Representative Sequence: NM_005428
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304076(uc002mfu.1 uc010xjh.1 uc010dva.1 uc002mfv.1)
    ENST00000539284

    miRNA
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    hsa-miR-24 hsa-miR-340
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1 

    8 DOTS entries:

    DT.121501823  DT.100021082  DT.200575  DT.97838137  DT.91692965  DT.121501814  DT.40221170  DT.40237954 

    24/56 AceView cDNA sequences (see all 56):

    BU196930 AW316763 BQ688696 BM916915 NM_005428 BC013361 BQ958817 BG284436 
    BM807186 BM829321 CB529026 BQ051816 BX374047 BX362424 X83931 CD742670 
    AI886795 AW402629 BM713574 BF032921 BQ685450 AL557286 CA425579 BQ928720 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                          -                                                                                 
    SP2:              -                                                                                                                                             
    SP3:              -                             -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for VAV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTAATTTAT
    VAV1 Expression
    About this image
    See VAV1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAV1

    SOURCE GeneReport for Unigene cluster: Hs.116237

    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types

        SABiosciences Expression via Pathway-Focused PCR Arrays including VAV1: 
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              T-cell & B-cell Activation in human mouse rat
              Hematopoiesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VAV1 gene from 3/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.172852 Transcribed sequence with weak similarity to protein more 74.2(n)    AL922920.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vav1 , 3 Rho protein signal transduction
    guanyl-nucleotide more3
    CG7893-PA1
    34(a)3
    50.38(n)1
    37.38(a)1
      329201  NM_133144.31  NP_573372.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C35B8.23 vav proto-oncogene 29(a)   X(9252696-9259556)   --


    ENSEMBL Gene Tree for VAV1 (if available)
    TreeFam Gene Tree for VAV1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAV1 gene
    ARHGEF62  PLEKHG22  PLEKHG32  PREX22  ARHGEF72  TIAM12  SPATA132  TIAM22  
    ARHGEF92  VAV32  VAV22  ARHGEF42  PLEKHG12  PREX12  
    14 SIMAP similar genes for VAV1 using alignment to 5 protein entries:     VAV_HUMAN (see all proteins):
    ARHGEF7    SH3RF3    VAV3    SH3GL2    GRAP2    SORBS3
    VAV2    ITSN1    PRKCH    GRB2    GRAP    PTPN11
    GRAPL    SH3GL1

    VAV1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2002 NCBI SNPs in VAV1 are shown (see all 2002    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420223131,2
    --6770833(+) GCAGTC/GAGCTA 3 -- us2k10--------
    rs1897322661,2
    --6770960(+) GAGTTC/TGAGAC 3 -- us2k10--------
    rs1812868511,2
    --6770966(+) GAGACC/GAGCCT 3 -- us2k10--------
    rs104087011,2
    C,F--6770980(+) caacaT/Agctga 3 -- us2k14Minor allele frequency- A:0.25NA WA CSA 8
    rs1379491461,2
    --6771249(+) CCTGAA/GGTCAG 3 -- us2k10--------
    rs42731521,2
    --6771365(+) gctgaA/C/Gacagg 3 -- us2k10--------
    rs1439532111,2
    --6771376(+) AGAATC/TGCTTG 3 -- us2k10--------
    rs621251281,2
    C--6771447(+) GAGAGC/TGAAAC 3 -- us2k10--------
    rs1861461601,2
    --6771456(+) ACTCCA/GTCTCA 3 -- us2k10--------
    rs2002978731,2
    --6771473(+) AAAAA-/AAGAAGAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for VAV1 (6772722 - 6857371 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for VAV1
         9 CNVs: 5341 78049 8862 67449 78048 5340 5077 5342 37710
         2 Indels: 78047 89046

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VAV1 for disorders           About GeneDecksing

    OMIM gene information: 164875    OMIM disorders: --

    20/29 diseases for VAV1 (see all 29):    About MalaCards
    wiskott-aldrich syndrome    diffuse large b-cell lymphoma    hematopoiesis    b-cell lymphomas
    common variable immunodeficiency    myeloproliferative disorder    systemic lupus erythematosus    acute promyelocytic leukemia
    lupus erythematosus    cherubism    burkitt's lymphoma    protein s deficiency
    leukemia    lymphoblastic leukemia    pancreatic cancer    myeloid leukemia
    hepatitis b    breast cancer    myeloma    t-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for VAV1:
    Cherubism

    10/15 Novoseek disease relationships for VAV1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 40 2 10706671 (1), 16493040 (1)
    leukemia t-cell 35.6 4 10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1)
    leukemia 25.6 7 2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6)
    hematopoietic malignancies 21.3 1 8608221 (1)
    myeloproliferative disorders 14.1 2 15878332 (1)
    leukaemia lymphocytic 12 3 16704440 (3)
    tumors 5.09 5 9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1)
    lymphoma 2.21 3 15964830 (1), 9178638 (1), 14586401 (1)
    dysplasia 0 2 8994827 (2)
    myeloma 0 3 9013873 (1), 10673353 (1)

    Human Genome Epidemiology (HuGE) Navigator: VAV1 (4 documents)
    Tumor Gene Database (TGDB): VAV1

    Export disorders for VAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAV1 gene, integrated from 9 sources (see all 470):
    (articles sorted by number of sources associating them with VAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)1, 2, 9 Denkinger D.J.... Kawahara R.S. (2000)
    2. Mechanism of activation of the vav protooncogene. (PubMed id 2069873)1, 2, 9 Coppola J.... Barbacid M. (1991)
    3. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)1, 2, 9 Adams J.M.... Harvey R. (1992)
    4. A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. (PubMed id 19207108)1, 2, 9 Gao C. and Blystone S.D. (2009)
    5. Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)1, 2, 9 Katzav S.... Pulido D. (1991)
    6. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)1, 2, 9 Houlard M....Varin-Blank N. (2005)
    7. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)1, 2, 9 Miller S.L....Clevenger C.V. (2005)
    8. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (2002)
    9. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2, 9 Yabana N. and Shibuya M. (2002)
    10. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)1, 2, 9 Germani A.... Varin-Blank N. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7409 HGNC: 12657 AceView: VAV1 Ensembl:ENSG00000141968 euGenes: HUgn7409
    ECgene: VAV1 Kegg: 7409 H-InvDB: VAV1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAV1 gene:
    Search GeneIP for patents involving VAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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