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Aliases for VAV1 Gene

Aliases for VAV1 Gene

  • Vav Guanine Nucleotide Exchange Factor 1 2 3 5
  • Vav 1 Guanine Nucleotide Exchange Factor 2 3
  • Vav 1 Oncogene 2 3
  • VAV 3 4
  • Proto-Oncogene Vav 3

External Ids for VAV1 Gene

Previous HGNC Symbols for VAV1 Gene

  • VAV

Previous GeneCards Identifiers for VAV1 Gene

  • GC19P006867
  • GC19P006712
  • GC19P006723
  • GC19P006535

Summaries for VAV1 Gene

Entrez Gene Summary for VAV1 Gene

  • This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for VAV1 Gene

VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with VAV1 include Common Variable Immunodeficiency. Among its related pathways are Signaling by GPCR and CXCR4-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot for VAV1 Gene

  • Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Gene Wiki entry for VAV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV1 Gene

Genomics for VAV1 Gene

Regulatory Elements for VAV1 Gene

Enhancers for VAV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F006270 1.5 FANTOM5 ENCODE 15.3 -497.3 -497316 10.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF557 SNRPEP4 SAFB ENSG00000267571 VMAC ACSBG2 LOC390877 MBD3L3 MBD3L5 FLJ25758
GH19F006055 1.8 FANTOM5 Ensembl ENCODE 10.4 -710.3 -710268 14.0 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF766 CBX5 ZNF548 FOS RFX2 ACSBG2 SAFB SAFB2 PRR22 GTF2F1 SNRPEP4 VAV1 SLC25A41 CATSPERD
GH19F006515 1.7 FANTOM5 Ensembl ENCODE 10.4 -254.9 -254864 4.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ENSG00000267571 ZNF557 SNRPEP4 VMAC LOC390877 FLJ25758 MBD3L3 MBD3L5 MIR6791 ACSBG2
GH19F006733 1.4 Ensembl ENCODE 10.6 -34.9 -34916 8.1 CREB3L1 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 GPR108 ENSG00000269680 FLJ25758 MBD3L5 MBD3L3 LOC390877 ACSBG2 ALKBH7 VAV1 VMAC
GH19F005798 1.3 Ensembl ENCODE 10.4 -973.3 -973263 0.9 HDGF ATF1 ARNT CREB3L1 ZNF766 CBX5 ELK1 GATA2 NCOA1 REST DUS3L CATSPERD LONP1 FUT6 FUT3 FUT5 NDUFA11 VMAC VAV1 NRTN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAV1 on UCSC Golden Path with GeneCards custom track

Promoters for VAV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001014785 632 1801 HDAC1 TBP ATF1 PKNOX1 ZBTB40 EGR1 ZNF143 ETV6 KDM4B CREM

Genomic Location for VAV1 Gene

Chromosome:
19
Start:
6,772,668 bp from pter
End:
6,857,366 bp from pter
Size:
84,699 bases
Orientation:
Plus strand

Genomic View for VAV1 Gene

Genes around VAV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV1 Gene

Proteins for VAV1 Gene

  • Protein details for VAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15498-VAV_HUMAN
    Recommended name:
    Proto-oncogene vav
    Protein Accession:
    P15498
    Secondary Accessions:
    • B4DVK9
    • M0QXX6
    • Q15860

    Protein attributes for VAV1 Gene

    Size:
    845 amino acids
    Molecular mass:
    98314 Da
    Quaternary structure:
    • Interacts with SHB (PubMed:12084069). Interacts with APS, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity).
    Miscellaneous:
    • Vav stands for the sixth letter of the Hebrew alphabet.
    SequenceCaution:
    • Sequence=BAG62721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAV1 Gene

    Alternative splice isoforms for VAV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV1 Gene

Post-translational modifications for VAV1 Gene

  • Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.
  • Ubiquitination at Lys 73, Lys 222, Lys 292, Lys 307, Lys 353, Lys 410, Lys 429, Lys 444, Lys 751, and Lys 782
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VAV1 Gene

Domains & Families for VAV1 Gene

Suggested Antigen Peptide Sequences for VAV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15498

UniProtKB/Swiss-Prot:

VAV_HUMAN :
  • The DH domain is involved in interaction with CCPG1.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The DH domain is involved in interaction with CCPG1.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with VAV1: view

Function for VAV1 Gene

Molecular function for VAV1 Gene

GENATLAS Biochemistry:
VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the calcium,ERK and FNKB pathways
UniProtKB/Swiss-Prot Function:
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Gene Ontology (GO) - Molecular Function for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 2477241
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005515 protein binding IPI 8673706
GO:0030676 Rac guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with VAV1: view
genes like me logo Genes that share phenotypes with VAV1: view

Animal Models for VAV1 Gene

MGI Knock Outs for VAV1:

Animal Model Products

miRNA for VAV1 Gene

miRTarBase miRNAs that target VAV1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV1 Gene

Localization for VAV1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAV1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with VAV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV1 Gene

Pathways & Interactions for VAV1 Gene

genes like me logo Genes that share pathways with VAV1: view

SIGNOR curated interactions for VAV1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006909 phagocytosis IEA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with VAV1: view

Drugs & Compounds for VAV1 Gene

(21) Drugs for VAV1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for VAV1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with VAV1: view

Transcripts for VAV1 Gene

Unigene Clusters for VAV1 Gene

Vav 1 guanine nucleotide exchange factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for VAV1 Gene

GeneLoc Exon Structure for
VAV1
ECgene alternative splicing isoforms for
VAV1

Expression for VAV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VAV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV1 Gene

This gene is overexpressed in Whole Blood (x27.7) and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for VAV1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (41.8), Lymph node (9.3), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAV1 Gene



Protein tissue co-expression partners for VAV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VAV1 Gene:

VAV1

SOURCE GeneReport for Unigene cluster for VAV1 Gene:

Hs.116237

mRNA Expression by UniProt/SwissProt for VAV1 Gene:

P15498-VAV_HUMAN
Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types.
genes like me logo Genes that share expression patterns with VAV1: view

Primer Products

Orthologs for VAV1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAV1 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia VAV1 34 35
  • 91.31 (n)
cow
(Bos Taurus)
Mammalia VAV1 34 35
  • 89.73 (n)
rat
(Rattus norvegicus)
Mammalia Vav1 34
  • 86.08 (n)
mouse
(Mus musculus)
Mammalia Vav1 34 16 35
  • 85.72 (n)
oppossum
(Monodelphis domestica)
Mammalia VAV1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAV1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAV1 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497964 34
  • 67.34 (n)
zebrafish
(Danio rerio)
Actinopterygii VAV1 (2 of 2) 35
  • 75 (a)
OneToMany
VAV1 (1 of 2) 35
  • 57 (a)
OneToMany