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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VAV1 Gene

protein-coding GIFtS: 68
GCID: GC19P006772

vav 1 guanine nucleotide exchange factor

(Previous name: vav 1 oncogene )
(Previous symbol: VAV)

Explore 29 diseases affiliated with
VAV1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vav 1 Guanine Nucleotide Exchange Factor¹ ²
VAV¹ ² ³ ⁵
Vav 1 Oncogene¹ ²
Proto-Oncogene Vav²

External Ids:	HGNC: 12657¹	Entrez Gene: 7409²	Ensembl: ENSG00000141968⁷	OMIM: 164875⁵	UniProtKB: P15498³

Export aliases for VAV1 gene to outside databases

Previous GC identifers: GC19P006867 GC19P006712 GC19P006723 GC19P006535

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAV1:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho

family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.

The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The

encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and

binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK

signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced

transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell

differentiation and/or proliferation

Gene Wiki entry for VAV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VAV1 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VAV1 promoter sequence

Search SABiosciences Chromatin IP Primers for VAV1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAV1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.2

VAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P006772: view genomic region (about GC identifiers)

Start:	6,772,722 bp from pter	End:	6,857,371 bp from pter
Size:	84,650 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See protein sequence)

Recommended Name: Proto-oncogene vav

Size: 845 amino acids; 98314 Da

Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and

ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a

B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and

down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2. Interacts with HCK (By

similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with

PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54 (By similarity)

Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet

Sequence caution: Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;

5 PDB 3D structures from and Proteopedia for VAV1:

2CRH (3D)

2LCT (3D)

2ROR (3D)

3BJI (3D)

3KY9 (3D)

Secondary accessions: Q15860

Explore the universe of human proteins at neXtProt for VAV1: NX_P15498

Post-translational modifications:

Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).

Phosphorylated by FYN¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15498

VAV1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001245135.1 NP_001245136.1 NP_005419.2

ENSEMBL proteins:

ENSP00000302269 ENSP00000443242

Reactome Protein details: P15498
Human Recombinant Protein Products for VAV1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: VAV1 OriGene Protein Over-expression Lysate: VAV1 OriGene Custom Protein Services for VAV1
	GenScript Custom Purified and Recombinant Proteins Services for VAV1
	Novus Biologicals VAV1 Protein Novus Biologicals VAV1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VAV1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--

VAV1 for ontologies About GeneDecksing

VAV1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of VAV1
	R&D Systems Antibodies for VAV1 (Vav-1)
	Cell Signaling Technology (CST) Antibodies for VAV1
	OriGene Antibodies (see all 3): VAV1 OriGene Custom Antibody Services for VAV1
	GenScript Custom Superior Antibodies Services for VAV1
	Novus Biologicals VAV1 Antibodies
	Abcam antibodies for VAV1
	Uscn Antibodies for VAV1
	ThermoFisher Antibodies for VAV1

Assay Products for VAV1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VAV1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VAV1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VAV1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR001331 GDS_CDC24_CS

IPR001715 CH-domain

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR003096 SM22_calponin

Graphical View of Domain Structure for InterPro Entry P15498

ProtoNet protein and cluster: P15498

5/6 Blocks protein families (see all 6):

IPB000219 DH domain

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001715 Calponin-like actin-binding

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Domain: The DH domain is involved in interaction with CCPG1 (By similarity)

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VAV_HUMAN, P15498

Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell

differentiation and/or proliferation

Genatlas biochemistry entry for VAV1:

VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the

calcium,ERK and FNKB pathways

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	2477241
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	18692475
GO:0005543	phospholipid binding	IEA	--

VAV1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for VAV1:

Increased S DNA content

9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Vav1):

cellular	digestive/alimentary	embryogenesis	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	normal	reproductive system

VAV1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for VAV1: Vav1^tm2Bbd Vav1^tm1Tyb Vav1^tm1Bbd

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VAV1

miRNA Products:		OriGene 3'-UTR Clone: VAV1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAV1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate VAV1:
		hsa-miR-24 hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: VAV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAV1 (see all 7) OriGene shRNA RFP: VAV1 OriGene siRNA: VAV1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against VAV1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for VAV1
			Sirion Biotech Customized adenovirus for overexpression of VAV1 Sirion Biotech Customized adenovirus for potent knockdown of VAV1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAV1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAV1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VAV1 (NM_005428)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VAV1
		Search LifeMap BioReagents cell lines for VAV1
		Sirion Biotech Customized stable knockdown cell line services for VAV1 Sirion Biotech Customized inducible knockdown cell line services for VAV1 Sirion Biotech Customized stable overexpressing cell line services for VAV1 Sirion Biotech Customized inducible overexpressing cell line services for VAV1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/68 super-pathways (see all 68) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB4 signaling	1.00	Signaling by SCF-KIT	0.72

Cell death signalling via NRAGE, NRIF and NADE

Cell death signalling via NRAGE, NRIF and NADE	1.00	G alpha (12/13) signalling events	0.39
NRAGE signals death through JNK	0.74	Rho GTPase cycle	0.25
p75 NTR receptor-mediated signalling	0.73	Signaling by Rho GTPases	0.25

PKC-Theta Pathway

PKC-Theta Pathway	1.00	Fc-EpsilonRI Pathway	0.42
TCR Signaling	0.68	PDGF Pathway	0.35
ITK and TCR Signaling	0.54

Development Angiotensin signaling via PYK2

	Development Angiotensin signaling via PYK2	1.00			Development_EPO-induced MAPK pathway	0.49
	Development_Angiotensin signaling via PYK2	0.98			Development EPO-induced MAPK pathway	0.49

Pathway sources
See GeneCards unified pathways
Show all pathways

5/20 EMD Millipore Pathways for VAV1 (see all 20)

	Chemotaxis CXCR4 signaling pathway
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling Role of PDGFs in cell migration
	Immune response Role of integrins in NK cells cytotoxicity
	Development Prolactin receptor signaling

5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VAV1 (see all 20)

	Fc-GammaR Pathway
	G12-G13 in Cellular Signaling
	Interferon Pathway
	PDGF Pathway
	PI3K Signaling in B-Lymphocyte

1 Cell Signaling Technology (CST) Pathway for VAV1

Cytoskeletal Signaling

5/20 GeneGo (Thomson Reuters) Pathways for VAV1 (see all 20)

	G-protein signaling Regulation of RAC1 activity
	Cytoskeleton remodeling Role of PDGFs in cell migration
	G-protein signaling Rac2 regulation pathway
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	Immune response CD28 signaling

5/20 BioSystems Pathways for VAV1 (see all 20)

	Focal Adhesion
	EGFR1 Signaling Pathway
	IL-6 Signaling Pathway
	Kit Receptor Signaling Pathway
	IL-2 Signaling Pathway

5/51 Reactome Pathways for VAV1 (see all 51)

	CD28 dependent Vav1 pathway
	Costimulation by the CD28 family
	G alpha (12/13) signalling events
	Signaling by EGFR in Cancer
	Downstream signal transduction

5/9 Kegg Pathways (Kegg details for VAV1) (see all 9):

	Chemokine signaling pathway
	Focal adhesion
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway

VAV1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VAV1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/192 Interacting proteins for VAV1 (P15498^{1, 2, 3} ENSP00000302269⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 192)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LCP2	Q13094²^,³, ENSP00000046794⁴	MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8224277 MINT-8037411 MINT-8037350 MINT-8037380 MINT-8029621 I2D: score=7 STRING: ENSP00000046794
SH3BP2	P78314²^,³, ENSP00000348685⁴	MINT-4563411 MINT-4549720 MINT-7301369 MINT-7301313 MINT-7301258 MINT-7301359 MINT-8026718 MINT-7301343 I2D: score=3 STRING: ENSP00000348685
ZNF655	Q8N720¹^,²^,³, ENSP00000393876⁴	EBI-625518,EBI-741438 MINT-50591 MINT-50593 MINT-50590 I2D: score=3 STRING: ENSP00000393876
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-7226662 MINT-7226674 MINT-7226716 MINT-7226645 MINT-7226592 I2D: score=2 STRING: ENSP00000361423
LCK	P06239²^,³, ENSP00000337825⁴	MINT-8028153 MINT-8224277 MINT-8025628 I2D: score=3 STRING: ENSP00000337825

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	TAS	2477241
GO:0006909	phagocytosis	--	--
GO:0006915	apoptotic process	TAS	--
GO:0006955	immune response	--	--
GO:0007229	integrin-mediated signaling pathway	--	--

VAV1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

VAV1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VAV1

10/843 HMDB Compounds for VAV1 (see all 843) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--
DG(14:0/18:3(6Z,9Z,12Z)/0:0)	Diacylglycerol(14:0/18:3n6) (see all 16)	--	--

10/37 Novoseek chemical compound relationships for VAV1 gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	80.5	346	11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99)
gdp	75.6	41	8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 26)
gtp	65.5	39	8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26)
phosphatidylinositol	61	22	9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16)
phosphoinositide	53.6	20	11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12)
guanine	50.8	12	12496381 (4), 20147552 (2), 19801678 (1), 9444953 (1) (see all 8)
guanosine	49.6	5	9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1)
piceatannol	39.1	1	11331248 (1)
herbimycin a	36.4	5	8133029 (2), 8809042 (1)
threonine	33.8	12	8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about VAV1 / VAV

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VAV1 gene (3 alternative transcripts):

NM_001258206.1 NM_001258207.1 NM_005428.3

Unigene Cluster for VAV1:

Vav 1 guanine nucleotide exchange factor

Hs.116237 [show with all ESTs]

Unigene Representative Sequence: NM_005428

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000304076(uc002mfu.1 uc010xjh.1 uc010dva.1 uc002mfv.1)

ENST00000539284

miRNA Products:		OriGene 3'-UTR Clone: VAV1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAV1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate VAV1:
		hsa-miR-24 hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: VAV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAV1 (see all 7) OriGene shRNA RFP: VAV1 OriGene siRNA: VAV1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against VAV1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VAV1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VAV1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VAV1 (NM_005428)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VAV1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VAV1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAV1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAV1

Additional cDNA sequence:

AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1

8 DOTS entries:

DT.121501823 DT.100021082 DT.200575 DT.97838137 DT.91692965 DT.121501814 DT.40221170 DT.40237954

24/56 AceView cDNA sequences (see all 56):

BU196930 AW316763 BQ688696 BM916915 NM_005428 BC013361 BQ958817 BG284436

BM807186 BM829321 CB529026 BQ051816 BX374047 BX362424 X83931 CD742670

AI886795 AW402629 BM713574 BF032921 BQ685450 AL557286 CA425579 BQ928720

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:																									-
SP2:					-
SP3:					-										-		-
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for VAV1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VAV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAATTTAT

About this image
See VAV1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VAV1

SOURCE GeneReport for Unigene cluster: Hs.116237

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types

SABiosciences Expression via Pathway-Focused PCR Arrays including VAV1:

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Hematopoiesis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for VAV1 gene from 3/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
zebrafish (Danio rerio)	Actinopterygii	Dr.17285²	Transcribed sequence with weak similarity to protein more	74.2(n)	AL922920.1
fruit fly (Drosophila melanogaster)	Insecta	vav^{1 , 3}	Rho protein signal transduction guanyl-nucleotide more³ CG7893-PA¹	34(a)³ 50.38(n)¹ 37.38(a)¹	32920¹ NM_133144.3¹ NP_573372.1¹
worm (Caenorhabditis elegans)	Secernentea	C35B8.2³	vav proto-oncogene	29(a)	X(9252696-9259556) --

ENSEMBL Gene Tree for VAV1 (if available)
TreeFam Gene Tree for VAV1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VAV1 gene

ARHGEF6² PLEKHG2² PLEKHG3² PREX2² ARHGEF7² TIAM1² SPATA13² TIAM2²

ARHGEF9² VAV3² VAV2² ARHGEF4² PLEKHG1² PREX1²

14 SIMAP similar genes for VAV1 using alignment to 5 protein entries: VAV_HUMAN (see all proteins):

ARHGEF7 SH3RF3 VAV3 SH3GL2 GRAP2 SORBS3

VAV2 ITSN1 PRKCH GRB2 GRAP PTPN11

GRAPL SH3GL1

VAV1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142022313^1,2		--	6770833(+)	`GCAGTC/GAGCTA`	3	--	us2k¹		0	--	--	--	--
rs189732266^1,2		--	6770960(+)	`GAGTTC/TGAGAC`	3	--	us2k¹		0	--	--	--	--
rs181286851^1,2		--	6770966(+)	`GAGACC/GAGCCT`	3	--	us2k¹		0	--	--	--	--
rs10408701^1,2	C,F	--	6770980(+)	`caacaT/Agctga`	3	--	us2k¹		4		NA WA CSA	8
rs137949146^1,2		--	6771249(+)	`CCTGAA/GGTCAG`	3	--	us2k¹		0	--	--	--	--
rs4273152^1,2		--	6771365(+)	`gctgaA/C/Gacagg`	3	--	us2k¹		0	--	--	--	--
rs143953211^1,2		--	6771376(+)	`AGAATC/TGCTTG`	3	--	us2k¹		0	--	--	--	--
rs62125128^1,2	C	--	6771447(+)	`GAGAGC/TGAAAC`	3	--	us2k¹		0	--	--	--	--
rs186146160^1,2		--	6771456(+)	`ACTCCA/GTCTCA`	3	--	us2k¹		0	--	--	--	--
rs200297873^1,2		--	6771473(+)	`AAAAA-/AAGAAGAA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VAV1 (6772722 - 6857371 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for VAV1
9 CNVs: 5341 78049 8862 67449 78048 5340 5077 5342 37710
2 Indels: 78047 89046

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VAV1 for disorders           About GeneDecksing

OMIM gene information: 164875    OMIM disorders: --

20/29 diseases for VAV1 (see all 29):    About MalaCards

wiskott-aldrich syndrome diffuse large b-cell lymphoma hematopoiesis b-cell lymphomas

common variable immunodeficiency myeloproliferative disorder systemic lupus erythematosus acute promyelocytic leukemia

lupus erythematosus cherubism burkitt's lymphoma protein s deficiency

leukemia lymphoblastic leukemia pancreatic cancer myeloid leukemia

hepatitis b breast cancer myeloma t-cell leukemia

1 disease from the University of Copenhagen DISEASES database for VAV1:

Cherubism

10/15 Novoseek disease relationships for VAV1 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	40	2	10706671 (1), 16493040 (1)
leukemia t-cell	35.6	4	10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1)
leukemia	25.6	7	2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6)
hematopoietic malignancies	21.3	1	8608221 (1)
myeloproliferative disorders	14.1	2	15878332 (1)
leukaemia lymphocytic	12	3	16704440 (3)
tumors	5.09	5	9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1)
lymphoma	2.21	3	15964830 (1), 9178638 (1), 14586401 (1)
dysplasia	0	2	8994827 (2)
myeloma	0	3	9013873 (1), 10673353 (1)

Human Genome Epidemiology (HuGE) Navigator: VAV1 (4 documents)
Tumor Gene Database (TGDB): VAV1

Export disorders for VAV1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VAV1 gene, integrated from 9 sources (see all 470):
(articles sorted by number of sources associating them with VAV1)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)^{1, 2, 9} Denkinger D.J.... Kawahara R.S. (2000)
Mechanism of activation of the vav protooncogene. (PubMed id 2069873)^{1, 2, 9} Coppola J.... Barbacid M. (1991)
The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)^{1, 2, 9} Adams J.M.... Harvey R. (1992)
A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. (PubMed id 19207108)^{1, 2, 9} Gao C. and Blystone S.D. (2009)
Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)^{1, 2, 9} Katzav S.... Pulido D. (1991)
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)^{1, 2, 9} Houlard M....Varin-Blank N. (2005)
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)^{1, 2, 9} Miller S.L....Clevenger C.V. (2005)
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)^{1, 2, 9} Nishihara H....Tanaka S. (2002)
Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)^{1, 2, 9} Yabana N. and Shibuya M. (2002)
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)^{1, 2, 9} Germani A.... Varin-Blank N. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7409	HGNC: 12657	AceView: VAV1	Ensembl:ENSG00000141968	euGenes: HUgn7409
ECgene: VAV1	Kegg: 7409	H-InvDB: VAV1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VAV1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for VAV1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for VAV1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VAV1 gene:
Search GeneIP for patents involving VAV1

GeneCards and IP:
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vav 1 guanine nucleotide exchange factor

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vav 1 guanine nucleotide exchange factor

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