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VAV1 Gene

protein-coding GIFtS: 69

GC19P006723

vav 1 guanine nucleotide exchange factor
(Previous name: vav 1 oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VAV)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
VAV ^², ³, ⁵

Descriptions
oncogene vav ^²
vav 1 guanine nucleotide exchange factor ^²
vav 1 oncogene ^¹, ²
vav proto-oncogene ^²

External Ids
HGNC: 12657¹
Entrez Gene: 7409²
UniProtKB: P15498³
Ensembl: ENSG00000141968⁷

Search outside databases for aliases for VAV1 gene

Previous GC identifers: GC19P006867 GC19P006712

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VAV1:

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide

exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in

hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF

has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and

binding of these partners initiates profound morphological changes, cytoskeletal rearrangements

and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and

replication. [provided by RefSeq]

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading

to cell differentiation and/or proliferation

Gene Wiki entry for VAV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VAV1 gene

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.2

VAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P006723: (about GC identifiers)

Start:	6,723,722 bp from pter
End:	6,808,371 bp from pter
Size:	84,650 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See protein sequence)

Recommended Name: Proto-oncogene vav

Size: 845 amino acids; 98314 Da

Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA

and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK,

PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which

inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK (By

similarity)

Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet

Sequence caution: Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;

PDB structures from and Proteopedia :

2CRH (3D)

2ROR (3D)

3BJI (3D)

Secondary accessions: Q15860

Post-translational modifications:

Phosphorylated on tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005419.2

ENSEMBL proteins:

ENSP00000302269

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for VAV1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VAV1, Vav proteins)
	Human Recombinant Proteins from Abnova (VAV1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0043231	intracellular membrane-bounded organelle	IDA	18029348

About this table

Antibodies for VAV1:

	Invitrogen Antibodies for VAV1
	Millipore Mono- and Polyclonal Antibodies for the study of VAV1
	Sigma-Aldrich Antibodies for VAV1
	R&D Systems Antibodies for VAV1 (Vav-1)
	Cell Signaling Technology (CST) Antibodies for VAV1
	Antibodies from Abcam (VAV1, Vav proteins), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VAV1)
	Novus Biologicals Antibodies for VAV1

Assays for VAV1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15498

ProtoNet protein and cluster: P15498

5/6 Blocks protein families (see all 6 ):

IPB000219 DH domain

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001715 Calponin-like actin-binding

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Domain: The DH domain is involved in interaction with CCPG1 (By similarity)

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005428

Applied Biosystems Silencer® siRNAs for VAV1

Sigma-Aldrich siRNA for VAV1

Sigma-Aldrich shRNA Panels and shRNA for VAV1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005428
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005428
untagged cDNA clone in CMV expression vector: NM_005428

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005428

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498

Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading

to cell differentiation and/or proliferation

Genatlas biochemistry entry for VAV1:

VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell

receptor signals to the calcium,ERK and FNKB pathways

6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Vav1):

embryogenesis	hematopoietic system	immune system	lethality-prenatal/perinatal	normal
reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	2477241
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	10394361
GO:0008270	zinc ion binding	IEA	--
GO:0019992	diacylglycerol binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for VAV1 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Leukocyte Extravasation Signaling
CD28 Signaling in T Helper Cells
iCOS-iCOSL Signaling in T Helper Cells
Natural Killer Cell Signaling
B Cell Receptor Signaling

GeneDecks VAV1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VAV1

5/227 Interacting proteins for VAV1 (ENSP00000302269³ P15498^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 227 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹	STRING (score=.999) EBI-625518, EBI-401755
RAC1	P63000²	STRING (score=.996) MINT-6743318 MINT-6743329
SH3BP2	P78314²	STRING (score=.992) MINT-4563411 MINT-4549720
CDC42P2	P60953²	STRING (score=.997) MINT-6743356
CRK	P46108²	STRING (score=.724) MINT-17467

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006909	phagocytosis	IEA	--
GO:0006955	immune response	IEA	--
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007242	intracellular signaling cascade	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VAV1
10/28 Novoseek chemical compound relationships for VAV1 gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	80.65	330	11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99)
gdp	76.34	40	8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 25)
gtp	66.70	39	8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26)
phosphatidylinositol	60.41	22	9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16)
phosphoinositide	55.40	20	11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12)
guanosine	51.31	5	9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1)
piceatannol	41.26	1	11331248 (1)
threonine	35.72	12	8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6)
wortmannin	30.45	1	9488489 (1)
phosphatidylinositol-3,4,5-trisphosphate	30.42	2	9438848 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAV1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VAV1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005428

Sigma-Aldrich siRNA for VAV1

Sigma-Aldrich shRNA Panels and shRNA for VAV1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005428

REFSEQ mRNAs for VAV1 gene:

NM_005428.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005428

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005428
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005428
                                 untagged cDNA clone in CMV expression vector: NM_005428

Additional cDNA sequence:

AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1

8 DOTS entries:

DT.121501823 DT.100021082 DT.200575 DT.97838137 DT.91692965 DT.121501814 DT.40221170 DT.40237954

24/56 AceView cDNA sequences (see all 56 ):

BU196930 BM916915 BQ958817 BG284436 NM_005428 BQ688696 BC013361 AW316763

BM807186 X16316 BM829321 CA425579 BF039002 BF032921 CB529026 CD742670

BM713574 BX101430 AW402629 BX362424 AL557286 BX369494 X83931 AI886795

highest scoring ESTs for VAV1:

X16316 AA628345 AI586976 AI886722 AI886795 AW105491 AW316763 AW575217 BC013361 BE049420

Unigene Cluster for VAV1:

Vav 1 guanine nucleotide exchange factor

Hs.116237 [show with all ESTs]

Unigene Representative Sequence: NM_005428

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:																									-
SP2:					-
SP3:					-										-		-
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for VAV1

1 Ensembl transcript including schematic representation:

ENST00000304076

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VAV1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VAV1

¹ / ² / ³

4 probe-sets matching VAV1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34481_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.16	AF030227	0.20	1.00	0.72	1
1919_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.85	X16316	1.00	1.00	1.00	1
206219_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005428	0.60	1.00	0.82	1
206219_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VAV1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTAATTTAT

SOURCE GeneReport for Unigene cluster: Hs.116237
Expression variation in blood from EXPOLDB for VAV1
UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VAV1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAV1¹	--	vav 1 guanine nucleotide exchange factor	91.24(n) 96.21(a)	485016 XM_542134.2 XP_542134.2
chimpanzee (Pan troglodytes)	VAV1¹	--	vav 1 guanine nucleotide exchange factor	99.53(n) 99.74(a)	455647 XM_512321.2 XP_512321.2
rat (Rattus norvegicus)	Vav1¹	--	vav 1 guanine nucleotide exchange factor	86.04(n) 93.12(a)	25156 NM_012759.1 NP_036891.1
mouse (Mus musculus)	Vav1^{1, 5}	17 (32.70 cM)⁵	vav 1 oncogene^{1, 5}	85.68(n)¹ 93.02(a)¹	22324¹ NM_011691.3¹ NP_035821.2¹ AK088586⁵ AK132886⁵ (see all 28)
zebrafish (Danio rerio)	Dr.17285²	--	Transcribed sequence with weak similarity to protein more	74.2(n)	AL922920.1

About this table Species with no ortholog for VAV1

ENSEMBL Gene Tree for VAV1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VAV1 gene

TIAM2² VAV3² VAV2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/706 NCBI SNPs in VAV1 are shown (see all 706 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 159)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs461970^1,2	C,F,H,O	6808640(+)	`GTCATT/CTATTA`	1	--	ng3¹		12		EU EA WA NA	1048
	rs36097961^1,2	C,F	6801767(-)	`TTACCG/ATAAGC`	1	M/T	mis¹		5		NA EU EA WA	498
--	rs10408701^1,2	C	6721980(+)	`caacaA/Tgctga`	1	--	ng5¹		0	--	--	--	--
--	rs2660476^1,2	C	6723198(+)	`cagggA/Ggggaa`	1	--	ng5¹ trp³		0	--	--	--	--
	rs2660485^1,2	A,C,F,H,O	6743286(+)	`GGAGTT/CGGGAG`	1	--	int¹		7		NA EU EA WA	556
	rs2617824^1,2	A,C,F,H,O	6753616(+)	`TCCCTT/CGAGCC`	1	--	int¹ trp³		11		EU EA WA NA	982
	rs164022^1,2	A,C,F,H,O	6779040(-)	`AGAAAC/GAGCCA`	1	--	int¹		17		EU EA WA NS NA	1086
	rs308195^1,2	A,C,F,H,O	6787760(-)	`TATTAA/GCTTCC`	1	--	int¹		7		NA EU EA WA	562
	rs2617822^1,2	A,C,F,H,O	6752481(+)	`CAGAAA/GGGTTT`	1	--	int¹		7		NA EU EA WA	558
	rs2660489^1,2	A,C,F,H,O	6747330(+)	`GGGACC/TCCGGG`	1	--	int¹		12		EA NA EU WA	1052

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HapMap Linkage Disequilibrium images for VAV1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164875

10/15 Novoseek disease relationships for VAV1 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	41.90	2	10706671 (1), 16493040 (1)
leukemia t-cell	37.25	4	10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1)
hematopoietic malignancies	23.69	1	8608221 (1)
leukemia	21.59	7	2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6)
myeloproliferative disorders	16.25	2	15878332 (1)
leukaemia lymphocytic	14.16	3	16704440 (3)
lymphoma	4.75	3	15964830 (1), 9178638 (1), 14586401 (1)
tumors	4.06	5	9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1)
cancer	2.54	5	19100858 (1), 17590270 (1), 15634759 (1)
dysplasia	0.00	2	8994827 (2)

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1 PharmGKB disease relationship for VAV1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Tumor Gene Database: VAV1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/399 PubMed articles for VAV1 gene (see all 399 ):

Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)^{1, 3, 4} Denkinger D.J....Kawahara R.S. (2000)
Mechanism of activation of the vav protooncogene. (PubMed id 2069873)^{1, 3, 4} Coppola J.... Barbacid M. (1991)
The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)^{1, 3, 4} Adams J.M.... Harvey R. (1992)
Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)^{1, 3, 4} Katzav S.... Pulido D. (1991)
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)^{1, 3, 4} Houlard M....Varin-Blank N. (2005)
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)^{1, 3, 4} Nishihara H....Tanaka S. (2002)
Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)^{1, 3, 4} Yabana N. and Shibuya M. (2002)
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)^{1, 3, 4} Germani A.... Varin-Blank N. (1999)
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. (PubMed id 9438848)^{1, 2, 3} Han J....Broek D. (1998)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7409	HGNC: 12657	AceView: VAV1	Ensembl:ENSG00000141968	euGenes: HUgn7409
ECgene: VAV1	H-InvDB: VAV1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for VAV1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for VAV1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VAV1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Antibodies & Assays for VAV1

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	Antibodies (VAV1, Vav proteins)

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Antibodies for VAV1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VAV1 Gene at Home site.
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VAV1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for VAV1

Summaries
for VAV1

Genomic Location
for VAV1

Proteins
for VAV1

Protein Domains/
Families
for VAV1

Gene Function
for VAV1

Pathways & Interactions
for VAV1

Drugs & Compounds
for VAV1

Transcripts
for VAV1

Expression
for VAV1

Orthologs
for VAV1

Paralogs
for VAV1

SNPs/Variants
for VAV1

Disorders & Mutations
for VAV1

Medical News
for VAV1

Publications
for VAV1

Search for VAV1

Genome Databases showing VAV1

Other Databases showing VAV1

Specialized Databases showing VAV1

Licensable Technologies
for VAV1

Services
for VAV1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VAV1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor VAV1

Summariesfor VAV1

Genomic Locationfor VAV1

Proteinsfor VAV1

Protein Domains/Familiesfor VAV1

Gene Functionfor VAV1

Pathways & Interactionsfor VAV1

Drugs & Compoundsfor VAV1

Transcriptsfor VAV1

Expression for VAV1

Orthologsfor VAV1

Paralogsfor VAV1

SNPs/Variantsfor VAV1

Disorders & Mutationsfor VAV1

Medical Newsfor VAV1

Publicationsfor VAV1

Search for VAV1

Genome Databases showing VAV1

Other Databases showing VAV1

Specialized Databases showing VAV1

Licensable Technologiesfor VAV1

Servicesfor VAV1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VAV1

Summaries
for VAV1

Genomic Location
for VAV1

Proteins
for VAV1

Protein Domains/
Families
for VAV1

Gene Function
for VAV1

Pathways & Interactions
for VAV1

Drugs & Compounds
for VAV1

Transcripts
for VAV1

Expression
for VAV1

Orthologs
for VAV1

Paralogs
for VAV1

SNPs/Variants
for VAV1

Disorders & Mutations
for VAV1

Medical News
for VAV1

Publications
for VAV1

Licensable Technologies
for VAV1

Services
for VAV1