Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VAV1 Gene

Aliases for VAV1 Gene

  • Vav 1 Guanine Nucleotide Exchange Factor 2 3
  • VAV 3 4 6
  • Vav 1 Oncogene 2 3
  • Proto-Oncogene Vav 3

External Ids for VAV1 Gene

Previous HGNC Symbols for VAV1 Gene

  • VAV

Previous GeneCards Identifiers for VAV1 Gene

  • GC19P006867
  • GC19P006712
  • GC19P006723
  • GC19P006535

Summaries for VAV1 Gene

Entrez Gene Summary for VAV1 Gene

  • This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for VAV1 Gene

VAV1 (Vav 1 Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Diseases associated with VAV1 include cherubism and hiv-1. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot for VAV1 Gene

  • Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation

Gene Wiki entry for VAV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAV1 Gene

Genomics for VAV1 Gene

Regulatory Elements for VAV1 Gene

Transcription factor binding sites by QIAGEN in the VAV1 gene promoter:

Genomic Location for VAV1 Gene

Start:
6,772,668 bp from pter
End:
6,857,366 bp from pter
Size:
84,699 bases
Orientation:
Plus strand

Genomic View for VAV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAV1 Gene

Proteins for VAV1 Gene

  • Protein details for VAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15498-VAV_HUMAN
    Recommended name:
    Proto-oncogene vav
    Protein Accession:
    P15498
    Secondary Accessions:
    • B4DVK9
    • M0QXX6
    • Q15860

    Protein attributes for VAV1 Gene

    Size:
    845 amino acids
    Molecular mass:
    98314 Da
    Quaternary structure:
    • May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2. Interacts with HCK (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54 (By similarity).
    Miscellaneous:
    • Vav stands for the sixth letter of the Hebrew alphabet
    SequenceCaution:
    • Sequence=BAG62721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAV1 Gene

    Alternative splice isoforms for VAV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAV1 Gene

Proteomics data for VAV1 Gene at MOPED

Post-translational modifications for VAV1 Gene

  • Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.
  • Ubiquitination at Lys73, Lys222, Lys292, Lys307, Lys353, Lys410, Lys429, Lys444, Lys751, and Lys782
  • Modification sites at PhosphoSitePlus

Other Protein References for VAV1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAV1 (VAV1)

No data available for DME Specific Peptides for VAV1 Gene

Domains for VAV1 Gene

Gene Families for VAV1 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for VAV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15498

UniProtKB/Swiss-Prot:

VAV_HUMAN :
  • P15498
Domain:
  • The DH domain is involved in interaction with CCPG1.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with VAV1: view

Function for VAV1 Gene

Molecular function for VAV1 Gene

GENATLAS Biochemistry: VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the calcium,ERK and FNKB pathways
UniProtKB/Swiss-Prot Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation

Gene Ontology (GO) - Molecular Function for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 2477241
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity --
GO:0005515 protein binding IPI 10347175
GO:0030676 Rac guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with VAV1: view
genes like me logo Genes that share phenotypes with VAV1: view

Animal Models for VAV1 Gene

MGI Knock Outs for VAV1:

Animal Model Products

CRISPR Products

miRNA for VAV1 Gene

miRTarBase miRNAs that target VAV1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAV1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VAV1 Gene

Localization for VAV1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAV1 Gene COMPARTMENTS Subcellular localization image for VAV1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 3
cytoskeleton 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with VAV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VAV1 Gene

Pathways for VAV1 Gene

genes like me logo Genes that share pathways with VAV1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for VAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 2477241
GO:0006909 phagocytosis --
GO:0006955 immune response --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with VAV1: view

Compounds for VAV1 Gene

(843) HMDB Compounds for VAV1 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available

(37) Novoseek inferred chemical compound relationships for VAV1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 80.5 201
gdp 75.6 33
gtp 65.5 34
phosphatidylinositol 61 22
phosphoinositide 53.6 18
genes like me logo Genes that share compounds with VAV1: view

Transcripts for VAV1 Gene

Unigene Clusters for VAV1 Gene

Vav 1 guanine nucleotide exchange factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAV1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VAV1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for VAV1 Gene

GeneLoc Exon Structure for
VAV1
ECgene alternative splicing isoforms for
VAV1

Expression for VAV1 Gene

mRNA expression in normal human tissues for VAV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VAV1 Gene

This gene is overexpressed in Whole Blood (27.7) and Spleen (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAV1 Gene

SOURCE GeneReport for Unigene cluster for VAV1 Gene Hs.116237

mRNA Expression by UniProt/SwissProt for VAV1 Gene

P15498-VAV_HUMAN
Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types
genes like me logo Genes that share expressions with VAV1: view

In Situ Assay Products

Orthologs for VAV1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAV1 35
  • 99.61 (n)
  • 99.87 (a)
VAV1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAV1 35
  • 89.73 (n)
  • 95.62 (a)
VAV1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAV1 35
  • 91.31 (n)
  • 96.33 (a)
VAV1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vav1 35
  • 85.72 (n)
  • 93.14 (a)
Vav1 16
Vav1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAV1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAV1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vav1 35
  • 86.08 (n)
  • 93.24 (a)
chicken
(Gallus gallus)
Aves VAV1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497964 35
  • 67.34 (n)
  • 73.01 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17285 35
VAV1 (1 of 2) 36
  • 57 (a)
OneToMany
VAV1 (2 of 2) 36
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010292 35
  • 43.42 (n)
  • 34.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta vav 35
  • 50.31 (n)
  • 37.57 (a)
vav 36
  • 27 (a)
OneToMany
vav 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea vav-1 36
  • 27 (a)
OneToMany
C35B8.2 37
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC24 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1542 36
  • 37 (a)
OneToMany
Species with no ortholog for VAV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAV1 Gene

ENSEMBL:
Gene Tree for VAV1 (if available)
TreeFam:
Gene Tree for VAV1 (if available)

Paralogs for VAV1 Gene

Paralogs for VAV1 Gene

Selected SIMAP similar genes for VAV1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VAV1: view

Variants for VAV1 Gene

Sequence variations from dbSNP and Humsavar for VAV1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs162725 -- 6,819,717(-) CCACA(A/G)CCCCC intron-variant
rs162726 -- 6,845,459(-) AATTA(A/C)AAGGT intron-variant
rs162727 -- 6,844,995(-) atcaa(A/C)atttt intron-variant
rs164014 -- 6,848,561(+) ccatg(A/C)ccagc intron-variant
rs164015 -- 6,821,177(+) TGGGC(A/G)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAV1 Gene

Variant ID Type Subtype PubMed ID
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv519561 CNV Loss 19592680
esv2718071 CNV Deletion 23290073
esv2659812 CNV Deletion 23128226
dgv617e199 CNV Deletion 23128226
dgv136e55 CNV Gain 17911159
nsv529046 CNV Loss 19592680
esv2718072 CNV Deletion 23290073
esv2718074 CNV Deletion 23290073
esv2718075 CNV Deletion 23290073
nsv833729 CNV Loss 17160897
esv2718076 CNV Deletion 23290073
nsv510752 CNV Loss 20534489
esv29628 CNV Gain 19812545
nsv442451 CNV CNV 18776908
esv2718077 CNV Deletion 23290073
esv2718078 CNV Deletion 23290073

Relevant External Links for VAV1 Gene

HapMap Linkage Disequilibrium report
VAV1
Human Gene Mutation Database (HGMD)
VAV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAV1 Gene

Disorders for VAV1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for VAV1 Gene including...

Search for VAV1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for VAV1 Gene

(15) Novoseek inferred disease relationships for VAV1 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 40 2
leukemia t-cell 35.6 4
leukemia 25.6 6
hematopoietic malignancies 21.3 1
myeloproliferative disorders 14.1 1

Relevant External Links for VAV1

Genetic Association Database (GAD)
VAV1
Human Genome Epidemiology (HuGE) Navigator
VAV1
Tumor Gene Database (TGDB):
VAV1
genes like me logo Genes that share disorders with VAV1: view

No data available for UniProtKB/Swiss-Prot for VAV1 Gene

Publications for VAV1 Gene

  1. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PMID: 1565462) Adams J.M. … Harvey R. (Oncogene 1992) 3 4 23
  2. Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PMID: 2005887) Katzav S. … Pulido D. (Mol. Cell. Biol. 1991) 3 4 23
  3. Mechanism of activation of the vav protooncogene. (PMID: 2069873) Coppola J. … Barbacid M. (Cell Growth Differ. 1991) 3 4 23
  4. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. (PMID: 9438848) Han J. … Broek D. (Science 1998) 2 3 23
  5. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PMID: 10207103) Germani A. … Varin-Blank N. (Mol. Cell. Biol. 1999) 3 4 23

Products for VAV1 Gene

  • Addgene plasmids for VAV1

Sources for VAV1 Gene

Back to Top

Content