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Aliases & Descriptions for VAV1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| oncogene vav 2 | | vav 1 guanine nucleotide exchange factor 2 | | vav 1 oncogene 1, 2 | | vav proto-oncogene 2 |
|
| | Search outside databases for aliases for VAV1 genePrevious GC identifers: GC19P006867 GC19P006712 |
Summaries for VAV1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAV1: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq] UniProtKB/Swiss-Prot: VAV_HUMAN, P15498Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferationGene Wiki entry for VAV1 |
Genomic Location for VAV1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAV1 gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.2VAV1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P006723:
(about GC identifiers)
Start:
|
6,723,722 bp from pter |
End:
|
6,808,371 bp from pter |
Size:
|
84,650 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for VAV1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See
protein sequence)Recommended Name: Proto-oncogene vav Size: 845 amino acids; 98314 Da
Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK (By similarity)
Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet
Sequence caution: Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;
PDB structures from and Proteopedia :2CRH (3D)
 2ROR (3D)
 3BJI (3D)
 
Secondary accessions: Q15860Post-translational modifications:
Phosphorylated on tyrosine residues1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005419.2
ENSEMBL proteins: ENSP00000302269
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VAV1:  | Invitrogen Antibodies for VAV1 |  | Millipore Mono- and Polyclonal Antibodies for the study of VAV1 |  | Sigma-Aldrich Antibodies for VAV1 |  | R&D Systems Antibodies for VAV1 (Vav-1) |  | Cell Signaling Technology (CST) Antibodies for VAV1  |  | Antibodies from Abcam (VAV1, Vav proteins), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (VAV1) |  | Novus Biologicals Antibodies for VAV1 |
Assays for VAV1: | Protein
Domains/ Families for VAV1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P15498
ProtoNet protein and cluster: P15498 5/6 Blocks protein families (see all 6
): IPB000219 DH domain IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB001715 Calponin-like actin-binding IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: VAV_HUMAN, P15498Domain: The DH domain is involved in interaction with CCPG1 (By similarity)Similarity: Contains 1 CH (calponin-homology) domainSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 SH2 domainSimilarity: Contains 2 SH3 domains | Gene Function for VAV1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005428
Applied Biosystems Silencer® siRNAs for VAV1
Sigma-Aldrich siRNA for VAV1  Sigma-Aldrich shRNA Panels and shRNA for VAV1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005428                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005428                                  untagged cDNA clone in CMV expression vector: NM_005428 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005428
UniProtKB/Swiss-Prot: VAV_HUMAN, P15498Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferationGenatlas biochemistry entry for VAV1:VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the calcium,ERK and FNKB pathways6 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Vav1):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for VAV1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for VAV1 (Your Favorite Gene powered by Ingenuity) (see all 9
) 
Gene Network CentralTM Interacting Genes and Proteins Network for VAV1 
5/227 Interacting proteins for VAV1 (ENSP000003022693 P154981, 2) via UniProtKB, MINT, and/or STRING (see all 227
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006909 | phagocytosis |
IEA | -- | | GO:0006955 | immune response |
IEA | -- | | GO:0007229 | integrin-mediated signaling pathway |
IEA | -- | | GO:0007242 | intracellular signaling cascade |
IEA | -- | | GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- | About this table
|
Drugs & Compounds for VAV1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAV1 10/28 Novoseek chemical compound relationships for VAV1 gene (see all 28
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
80.65 |
330 |
11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99) |
| gdp |
76.34 |
40 |
8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 25) |
| gtp |
66.70 |
39 |
8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26) |
| phosphatidylinositol |
60.41 |
22 |
9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16) |
| phosphoinositide |
55.40 |
20 |
11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12) |
| guanosine |
51.31 |
5 |
9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1) |
| piceatannol |
41.26 |
1 |
11331248 (1) |
| threonine |
35.72 |
12 |
8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6) |
| wortmannin |
30.45 |
1 |
9488489 (1) |
| phosphatidylinositol-3,4,5-trisphosphate |
30.42 |
2 |
9438848 (1) |
About this table
|
Transcripts for VAV1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005428
Sigma-Aldrich siRNA for VAV1  Sigma-Aldrich shRNA Panels and shRNA for VAV1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005428 REFSEQ mRNAs for VAV1 gene: NM_005428.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005428               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005428                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005428                                  untagged cDNA clone in CMV expression vector: NM_005428  Additional cDNA sequence: AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1 8 DOTS entries: DT.121501823 DT.100021082 DT.200575 DT.97838137 DT.91692965 DT.121501814 DT.40221170 DT.40237954 24/56 AceView cDNA sequences (see all 56
):BU196930 BM916915 BQ958817 BG284436 NM_005428 BQ688696 BC013361 AW316763 BM807186 X16316 BM829321 CA425579 BF039002 BF032921 CB529026 CD742670 BM713574 BX101430 AW402629 BX362424 AL557286 BX369494 X83931 AI886795
highest scoring ESTs for VAV1:X16316 AA628345 AI586976 AI886722 AI886795 AW105491 AW316763 AW575217 BC013361 BE049420 Unigene Cluster for VAV1: Vav 1 guanine nucleotide exchange factor Hs.116237 [show with all ESTs]Unigene Representative Sequence: NM_005428
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAV1
1 Ensembl transcript including schematic representation: ENST00000304076
|
Expression for VAV1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAV1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAV1
1 / 2 / 3 4 probe-sets matching VAV1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTAATTTAT
SOURCE GeneReport for Unigene cluster: Hs.116237
Expression variation in blood from EXPOLDB for VAV1 UniProtKB/Swiss-Prot: VAV_HUMAN, P15498Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types |
Orthologs for VAV1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAV1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for VAV1
ENSEMBL Gene Tree for VAV1 | Paralogs for VAV1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAV1 gene
- TIAM22 VAV32 VAV22
|
SNPs/Variants for VAV1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAV1 (up to first 250kb)
|
Disorders & Mutations for VAV1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 164875
10/15 Novoseek disease relationships for VAV1 gene (see all 15
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| wiskott-aldrich syndrome |
41.90 |
2 |
10706671 (1), 16493040 (1) |
| leukemia t-cell |
37.25 |
4 |
10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1) |
| hematopoietic malignancies |
23.69 |
1 |
8608221 (1) |
| leukemia |
21.59 |
7 |
2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6) |
| myeloproliferative disorders |
16.25 |
2 |
15878332 (1) |
| leukaemia lymphocytic |
14.16 |
3 |
16704440 (3) |
| lymphoma |
4.75 |
3 |
15964830 (1), 9178638 (1), 14586401 (1) |
| tumors |
4.06 |
5 |
9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1) |
| cancer |
2.54 |
5 |
19100858 (1), 17590270 (1), 15634759 (1) |
| dysplasia |
0.00 |
2 |
8994827 (2) |
About this table
1 PharmGKB disease relationship for VAV1 geneAbout this table
Tumor Gene Database: VAV1
|
Medical News for VAV1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAV1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/399 PubMed articles for VAV1 gene (see all 399
):- Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)1, 3, 4 Denkinger D.J....Kawahara R.S. (2000)
- Mechanism of activation of the vav protooncogene. (PubMed id 2069873)1, 3, 4 Coppola J.... Barbacid M. (1991)
- The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)1, 3, 4 Adams J.M.... Harvey R. (1992)
- Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)1, 3, 4 Katzav S.... Pulido D. (1991)
- Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)1, 3, 4 Houlard M....Varin-Blank N. (2005)
- DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 3, 4 Nishihara H....Tanaka S. (2002)
- Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 3, 4 Yabana N. and Shibuya M. (2002)
- hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)1, 3, 4 Germani A.... Varin-Blank N. (1999)
- Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. (PubMed id 9438848)1, 2, 3 Han J....Broek D. (1998)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
|
Search for VAV1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAV1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAV1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAV1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAV1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAV1:

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