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VAV1 Gene

protein-coding   GIFtS: 72
GCID: GC19P006772

Vav 1 Guanine Nucleotide Exchange Factor

(Previous name: vav 1 oncogene)
(Previous symbol: VAV)
  See VAV1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vav 1 Guanine Nucleotide Exchange Factor1 2
VAV1 2 3 5
Vav 1 Oncogene1 2
Proto-Oncogene Vav2

External Ids:    HGNC: 126571   Entrez Gene: 74092   Ensembl: ENSG000001419687   OMIM: 1648755   UniProtKB: P154983   

Export aliases for VAV1 gene to outside databases

Previous GC identifers: GC19P006867 GC19P006712 GC19P006723 GC19P006535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAV1 Gene:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for
Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional
alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development
and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from
HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal
rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and
replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for VAV1 Gene:
VAV1 (vav 1 guanine nucleotide exchange factor) is a protein-coding gene. Diseases associated with VAV1 include cherubism, and hiv-1. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV3.

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
differentiation and/or proliferation

Gene Wiki entry for VAV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAV1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VAV1 promoter sequence
   Search Chromatin IP Primers for VAV1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.2

VAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006772:  view genomic region     (about GC identifiers)

Start:
6,772,722 bp from pter      End:
6,857,377 bp from pter
Size:
84,656 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See protein sequence)
Recommended Name: Proto-oncogene vav  
Size: 845 amino acids; 98314 Da
Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and
ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1
in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and
down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2. Interacts with HCK
(By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts
with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54 (By similarity)
Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet
Sequence caution: Sequence=BAG62721.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;
6 PDB 3D structures from and Proteopedia for VAV1:
2CRH (3D)        2LCT (3D)        2MC1 (3D)        2ROR (3D)        3BJI (3D)        3KY9 (3D)    
Secondary accessions: B4DVK9 M0QXX6 Q15860
Alternative splicing: 2 isoforms:  P15498-1   P15498-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VAV1: NX_P15498

Explore proteomics data for VAV1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By
    similarity). Phosphorylated by FYN1
  • Ubiquitination2 at Lys73, Lys222, Lys292, Lys307, Lys353, Lys410, Lys429, Lys444, Lys751, Lys782
  • Modification sites at PhosphoSitePlus

  • See VAV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001245135.1  NP_001245136.1  NP_005419.2  

    ENSEMBL proteins: 
     ENSP00000302269   ENSP00000472929   ENSP00000469450   ENSP00000472803   ENSP00000443242  
    Reactome Protein details: P15498

    VAV1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for VAV1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 10):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR001331 GDS_CDC24_CS

    Graphical View of Domain Structure for InterPro Entry P15498

    ProtoNet protein and cluster: P15498

    Selected Blocks protein domains (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Domain: The DH domain is involved in interaction with CCPG1 (By similarity)
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Find genes that share domains with VAV1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAV_HUMAN, P15498
    Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
    differentiation and/or proliferation

         Genatlas biochemistry entry for VAV1:
    VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to
    the calcium,ERK and FNKB pathways

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2477241
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005089Rho guanyl-nucleotide exchange factor activity ----
    GO:0005515protein binding IPI10347175
    GO:0030676Rac guanyl-nucleotide exchange factor activity IEA--
         
    Find genes that share ontologies with VAV1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VAV1:
     Increased S DNA content 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Vav1):
     cellular  digestive/alimentary  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with VAV1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VAV1: Vav1tm2Bbd Vav1tm1Tyb Vav1tm1Bbd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAV1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAV1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAV1

    miRNA
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    miRTarBase miRNAs that target VAV1:
    hsa-mir-26b-5p (MIRT029179)

    Block miRNA regulation of human, mouse, rat VAV1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate VAV1:
    hsa-miR-24 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidVAV1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VAV1
    Predesigned siRNA for gene silencing in human, mouse, rat VAV1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for VAV1

    Clone
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    GenScript: all cDNA clones in your preferred vector: VAV1 (NM_005428)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV1
    Addgene plasmids for VAV1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAV1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    mitochondrion3
    cytoskeleton2
    extracellular2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with VAV1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAV1 About   (see all 63)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    TCR Signaling Pathway0.36
    T cell receptor signaling pathway0.38
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin Signaling Pathway0.39


    Find genes that share SuperPaths with VAV1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VAV1 (see all 20)
        Fc-GammaR Pathway
    G12-G13 in Cellular Signaling
    Interferon Pathway
    PDGF Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for VAV1
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for VAV1 (see all 20)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    G-protein signaling Rac2 regulation pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD28 signaling

    Selected BioSystems Pathways for VAV1 (see all 20)
        Focal Adhesion
    EGFR1 Signaling Pathway
    Interferon type I
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway

    Selected Reactome Pathways for VAV1 (see all 14)
        CD28 dependent Vav1 pathway
    FCERI mediated MAPK activation
    G alpha (12/13) signalling events
    Regulation of signaling by CBL
    NRAGE signals death through JNK


    Selected Kegg Pathways  (Kegg details for VAV1) (see all 9):
        Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    B cell receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VAV1: 
              Focal Adhesions in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAV1 (P154981, 2, 3 ENSP000003022694) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130941, 2, 3, ENSP000000467944EBI-625518,EBI-346946 MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8224277 MINT-8037411 MINT-8037350 MINT-8037380 MINT-8029621 I2D: score=7 STRING: ENSP00000046794
    SH3BP2P783141, 2, 3, ENSP000003486854EBI-625518,EBI-727062 MINT-4563411 MINT-4549720 MINT-7301369 MINT-7301313 MINT-7301258 MINT-7301359 MINT-8026718 MINT-7301343 I2D: score=3 STRING: ENSP00000348685
    ABL1P005191, 2, 3, ENSP000003614234EBI-625518,EBI-375543 MINT-7226662 MINT-7226674 MINT-7226716 MINT-7226645 MINT-7226592 I2D: score=2 STRING: ENSP00000361423
    ZNF655Q8N7201, 2, 3, ENSP000003938764EBI-625518,EBI-625509 MINT-50591 MINT-50593 MINT-50590 I2D: score=3 STRING: ENSP00000393876
    KHDRBS1Q076661, 2, 3, ENSP000003138294EBI-625518,EBI-1364 MINT-7300651 MINT-7300587 MINT-7300628 I2D: score=1 STRING: ENSP00000313829
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS2477241
    GO:0006909phagocytosis ----
    GO:0006955immune response ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007229integrin-mediated signaling pathway IEA--

    Find genes that share ontologies with VAV1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAV1 (VAV)

    Selected HMDB Compounds for VAV1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Selected Novoseek inferred chemical compound relationships for VAV1 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.5 346 11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99)
    gdp 75.6 41 8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 26)
    gtp 65.5 39 8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26)
    phosphatidylinositol 61 22 9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16)
    phosphoinositide 53.6 20 11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12)
    guanine 50.8 12 12496381 (4), 20147552 (2), 19801678 (1), 9444953 (1) (see all 8)
    guanosine 49.6 5 9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1)
    piceatannol 39.1 1 11331248 (1)
    herbimycin a 36.4 5 8133029 (2), 8809042 (1)
    threonine 33.8 12 8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6)



    Find genes that share compounds with VAV1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VAV1 gene (3 alternative transcripts): 
    NM_001258206.1  NM_001258207.1  NM_005428.3  

    Unigene Cluster for VAV1:

    Vav 1 guanine nucleotide exchange factor
    Hs.116237  [show with all ESTs]
    Unigene Representative Sequence: NM_005428
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304076(uc002mfu.1 uc010xjh.1 uc010dva.1 uc002mfv.1)
    ENST00000602142 ENST00000596764 ENST00000599806 ENST00000594082 ENST00000597967
    ENST00000601452 ENST00000600396 ENST00000598270 ENST00000539284
    miRNA
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    hsa-miR-24 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidVAV1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: VAV1 (NM_005428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAV1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAV1
    Addgene plasmids for VAV1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAV1
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      QuantiFast Probe-based Assays in human, mouse, rat VAV1

    Additional mRNA sequence: 

    AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1 

    8 DOTS entries:

    DT.121501823  DT.100021082  DT.200575  DT.97838137  DT.91692965  DT.121501814  DT.40221170  DT.40237954 

    Selected AceView cDNA sequences (see all 56):

    BM807186 BQ958817 BU196930 AW316763 BM916915 BG284436 BC013361 BQ688696 
    NM_005428 AW402629 BX374047 BX362424 X83931 BQ928720 BF032921 AL557286 
    BQ685450 BM829321 BX369494 X16316 AA484949 BX101430 BM713574 AI886795 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                          -                                                                                 
    SP2:              -                                                                                                                                             
    SP3:              -                             -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for VAV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    VAV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAATTTAT
    VAV1 Expression
    About this image


    VAV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
             Trophoblast
     
     Thymus (Hematopoietic System)
             Thymus
    VAV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAV1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116237

    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VAV1: 
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              Hematopoiesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAV1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vav11 , 5 vav 1 oncogene1, 5 85.72(n)1
    93.14(a)1
      17 (29.76 cM)5
    223241  NM_011691.41  NP_035821.31 
     572791005 
    chicken
    (Gallus gallus)
    Aves VAV16
    vav 1 guanine nucleotide exchange factor
    53(a)
    1 ↔ 1
    JH375454.1(13888-15359)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004979641 proto-oncogene vav-like 67.34(n)
    73.01(a)
      100497964  XM_002940016.2  XP_002940062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.172852 Transcribed sequence with weak similarity to protein more 74.2(n)    AL922920.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vav1 , 3 Rho protein signal transduction
    guanyl-nucleotide more3
    vav1
    34(a)3
    50.31(n)1
    37.57(a)1
      329201  NM_167642.31  NP_728235.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C35B8.23 vav proto-oncogene 29(a)   X(9252696-9259556)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC246
    Guanine nucleotide exchange factor (GEF or GDP-rel...
    14(a)
    1 → many
    I(62840-65404) YAL041W


    ENSEMBL Gene Tree for VAV1 (if available)
    TreeFam Gene Tree for VAV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAV1 gene
    VAV32  VAV22  
    14 SIMAP similar genes for VAV1 using alignment to 4 protein entries:     VAV_HUMAN (see all proteins):
    ARHGEF7    SH3RF3    VAV3    SH3GL2    GRAP2    SORBS3
    VAV2    ITSN1    PRKCH    GRB2    GRAP    PTPN11
    GRAPL    SH3GL1

    Find genes that share paralogs with VAV1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAV1 (see all 2414)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711771181,2
    C--6700874(+) TCCAC-/CCAT  
            
    CCATC
    3 -- int11Minor allele frequency- CCAT:0.00NA 2
    rs1420223131,2
    --6770833(+) GCAGTC/GAGCTA 3 -- us2k10--------
    rs1897322661,2
    --6770960(+) GAGTTC/TGAGAC 3 -- us2k10--------
    rs1812868511,2
    --6770966(+) GAGACC/GAGCCT 3 -- us2k10--------
    rs104087011,2
    C,F--6770980(+) caacaT/Agctga 3 -- us2k14Minor allele frequency- A:0.25NA WA CSA 8
    rs340178941,2
    C--6771176(+) AAAAA-/A/AAAAA
    A
    /AAAAAAA
    GCCGG
    3 -- us2k11NA 2
    rs1379491461,2
    --6771249(+) CCTGAA/GGTCAG 3 -- us2k10--------
    rs42731521,2
    F--6771365(+) gctgaA/C/Gacagg 3 -- us2k10--------
    rs1439532111,2
    --6771376(+) AGAATC/TGCTTG 3 -- us2k10--------
    rs621251281,2
    C--6771447(+) GAGAGC/TGAAAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for VAV1 (6772722 - 6857377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VAV1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718074CNV Deletion23290073
    esv2718072CNV Deletion23290073
    esv2659812CNV Deletion23128226
    esv2718077CNV Deletion23290073
    esv2718076CNV Deletion23290073
    esv2718075CNV Deletion23290073
    dgv617e199CNV Deletion23128226
    esv2718071CNV Deletion23290073
    esv2718078CNV Deletion23290073
    dgv14e196CNV Duplication17116639

    Human Gene Mutation Database (HGMD): VAV1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164875    OMIM disorders: --

    2 diseases for VAV1:    
    About MalaCards
    cherubism    hiv-1

    1 disease from the University of Copenhagen DISEASES database for VAV1:
    Cherubism

    Find genes that share disorders with VAV1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VAV1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 40 2 10706671 (1), 16493040 (1)
    leukemia t-cell 35.6 4 10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1)
    leukemia 25.6 7 2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6)
    hematopoietic malignancies 21.3 1 8608221 (1)
    myeloproliferative disorders 14.1 2 15878332 (1)
    leukaemia lymphocytic 12 3 16704440 (3)
    tumors 5.09 5 9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1)
    lymphoma 2.21 3 15964830 (1), 9178638 (1), 14586401 (1)
    dysplasia 0 2 8994827 (2)
    myeloma 0 3 9013873 (1), 10673353 (1)

    Genetic Association Database (GAD): VAV1
    Human Genome Epidemiology (HuGE) Navigator: VAV1 (4 documents)
    Tumor Gene Database (TGDB): VAV1

    Export disorders for VAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAV1 gene, integrated from 10 sources (see all 484):
    (articles sorted by number of sources associating them with VAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)1, 2, 9 Denkinger D.J.... Kawahara R.S. (Biochim. Biophys. Acta 2000)
    2. Mechanism of activation of the vav protooncogene. (PubMed id 2069873)1, 2, 9 Coppola J.... Barbacid M. (Cell Growth Differ. 1991)
    3. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)1, 2, 9 Adams J.M.... Harvey R. (Oncogene 1992)
    4. A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. (PubMed id 19207108)1, 2, 9 Gao C. and Blystone S.D. (Biochem. J. 2009)
    5. Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)1, 2, 9 Katzav S.... Pulido D. (Mol. Cell. Biol. 1991)
    6. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)1, 2, 9 Houlard M.... Varin-Blank N. (Oncogene 2005)
    7. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)1, 2, 9 Miller S.L.... Clevenger C.V. (Mol. Endocrinol. 2005)
    8. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (Blood 2002)
    9. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2, 9 Yabana N. and Shibuya M. (Oncogene 2002)
    10. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)1, 2, 9 Germani A.... Varin-Blank N. (Mol. Cell. Biol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7409 HGNC: 12657 AceView: VAV1 Ensembl:ENSG00000141968 euGenes: HUgn7409
    ECgene: VAV1 Kegg: 7409 H-InvDB: VAV1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VAV1 gene:
    Search GeneIP for patents involving VAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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