Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VAT1L Gene

Aliases for VAT1L Gene

  • Vesicle Amine Transport 1-Like 2 3 5
  • Vesicle Amine Transport Protein 1 Homolog (T. Californica)-Like 2
  • EC 1.-.-.- 4
  • KIAA1576 4

External Ids for VAT1L Gene

Previous GeneCards Identifiers for VAT1L Gene

  • GC16P076380
  • GC16P077822
  • GC16P063578

Summaries for VAT1L Gene

GeneCards Summary for VAT1L Gene

VAT1L (Vesicle Amine Transport 1-Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is CRYZ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAT1L Gene

Genomics for VAT1L Gene

Regulatory Elements for VAT1L Gene

Promoters for VAT1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAT1L on UCSC Golden Path with GeneCards custom track

Genomic Location for VAT1L Gene

77,788,530 bp from pter
77,980,107 bp from pter
191,578 bases
Plus strand

Genomic View for VAT1L Gene

Genes around VAT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAT1L Gene

Proteins for VAT1L Gene

  • Protein details for VAT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptic vesicle membrane protein VAT-1 homolog-like
    Protein Accession:
    Secondary Accessions:
    • Q8IYW8

    Protein attributes for VAT1L Gene

    419 amino acids
    Molecular mass:
    45899 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13402.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAT1L Gene

neXtProt entry for VAT1L Gene

Proteomics data for VAT1L Gene at MOPED

Post-translational modifications for VAT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAT1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAT1L Gene

Domains & Families for VAT1L Gene

Suggested Antigen Peptide Sequences for VAT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with VAT1L: view

No data available for Gene Families for VAT1L Gene

Function for VAT1L Gene

Enzyme Numbers (IUBMB) for VAT1L Gene

Gene Ontology (GO) - Molecular Function for VAT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with VAT1L: view
genes like me logo Genes that share phenotypes with VAT1L: view

Animal Models for VAT1L Gene

MGI Knock Outs for VAT1L:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAT1L Gene

Localization for VAT1L Gene

Subcellular locations from

Jensen Localization Image for VAT1L Gene COMPARTMENTS Subcellular localization image for VAT1L gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VAT1L Gene

Pathways & Interactions for VAT1L Gene

SuperPathways for VAT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for VAT1L Gene


No data available for Pathways by source and SIGNOR curated interactions for VAT1L Gene

Drugs & Compounds for VAT1L Gene

(2) Drugs for VAT1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(4) Additional Compounds for VAT1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
genes like me logo Genes that share compounds with VAT1L: view

Transcripts for VAT1L Gene

mRNA/cDNA for VAT1L Gene

Unigene Clusters for VAT1L Gene

Vesicle amine transport protein 1 homolog (T. californica)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAT1L Gene

No ASD Table

Relevant External Links for VAT1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VAT1L Gene

mRNA expression in normal human tissues for VAT1L Gene

mRNA differential expression in normal tissues according to GTEx for VAT1L Gene

This gene is overexpressed in Brain - Hypothalamus (x9.5), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Cerebellar Hemisphere (x4.8), Brain - Caudate (basal ganglia) (x4.8), Brain - Cerebellum (x4.7), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for VAT1L Gene

This gene is overexpressed in Retina (38.9) and Spinal cord (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAT1L Gene

SOURCE GeneReport for Unigene cluster for VAT1L Gene Hs.461405

mRNA Expression by UniProt/SwissProt for VAT1L Gene

Tissue specificity: Detected in skin fibroblasts.
genes like me logo Genes that share expression patterns with VAT1L: view

Protein tissue co-expression partners for VAT1L Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for VAT1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAT1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VAT1L 35
  • 91.49 (n)
  • 97.37 (a)
VAT1L 36
  • 97 (a)
(Canis familiaris)
Mammalia VAT1L 35
  • 93.94 (n)
  • 97.85 (a)
VAT1L 36
  • 98 (a)
(Mus musculus)
Mammalia Vat1l 35
  • 89.13 (n)
  • 98.56 (a)
Vat1l 16
Vat1l 36
  • 99 (a)
(Pan troglodytes)
Mammalia VAT1L 35
  • 99.28 (n)
  • 99.28 (a)
VAT1L 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vat1l 35
  • 90.17 (n)
  • 98.56 (a)
(Monodelphis domestica)
Mammalia VAT1L 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia VAT1L 36
  • 93 (a)
(Gallus gallus)
Aves VAT1L 35
  • 81.66 (n)
  • 91.39 (a)
VAT1L 36
  • 91 (a)
(Anolis carolinensis)
Reptilia VAT1L 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vat1l 35
  • 77.8 (n)
  • 88.86 (a)
(Danio rerio)
Actinopterygii vat1l 35
  • 73.33 (n)
  • 77.84 (a)
vat1l 36
  • 83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006478 35
  • 61.62 (n)
  • 58.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 36
  • 24 (a)
Species with no ortholog for VAT1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAT1L Gene

Gene Tree for VAT1L (if available)
Gene Tree for VAT1L (if available)

Paralogs for VAT1L Gene

Paralogs for VAT1L Gene

(4) SIMAP similar genes for VAT1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VAT1L: view

Variants for VAT1L Gene

Sequence variations from dbSNP and Humsavar for VAT1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9711 -- 77,979,985(-) ACTTC(A/T)ATCAA utr-variant-3-prime
rs374693 -- 77,931,606(+) CATAC(G/T)TTTTA intron-variant
rs374987 -- 77,967,481(-) CTCTT(G/T)GAGCC intron-variant
rs375457 -- 77,892,210(+) GATGA(A/C)TGAGG intron-variant
rs376490 -- 77,871,761(+) CGAAC(G/T)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAT1L Gene

Variant ID Type Subtype PubMed ID
nsv457543 CNV Gain 19166990
esv2714737 CNV Deletion 23290073
nsv906962 CNV Gain 21882294
esv2618540 CNV Insertion 19546169
esv1635984 CNV Insertion 17803354
nsv510422 CNV Loss 20534489
esv1937488 CNV Deletion 18987734
esv2618898 CNV Deletion 19546169
esv2671939 CNV Deletion 23128226
dgv2919n71 CNV Gain 21882294
esv6734 CNV Loss 19470904
esv2714738 CNV Deletion 23290073
esv2714739 CNV Deletion 23290073
nsv906964 CNV Gain 21882294
nsv833293 CNV Gain 17160897
nsv1887 CNV Insertion 18451855
nsv518329 CNV Loss 19592680
esv28896 CNV Loss 19812545
nsv528395 CNV Gain 19592680
nsv103488 CNV Loss 16902084
nsv103420 CNV Loss 16902084

Variation tolerance for VAT1L Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAT1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAT1L Gene

Disorders for VAT1L Gene

Relevant External Links for VAT1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VAT1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAT1L Gene

Publications for VAT1L Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 4 48 67
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for VAT1L Gene

Sources for VAT1L Gene

Back to Top