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Aliases for VAT1L Gene

Aliases for VAT1L Gene

  • Vesicle Amine Transport 1 Like 2 3 5
  • Vesicle Amine Transport Protein 1 Homolog (T. Californica)-Like 2
  • Vesicle Amine Transport 1-Like 2
  • EC 1.-.-.- 4
  • KIAA1576 4

External Ids for VAT1L Gene

Previous GeneCards Identifiers for VAT1L Gene

  • GC16P076380
  • GC16P077822
  • GC16P063578

Summaries for VAT1L Gene

GeneCards Summary for VAT1L Gene

VAT1L (Vesicle Amine Transport 1 Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is VAT1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAT1L Gene

Genomics for VAT1L Gene

Regulatory Elements for VAT1L Gene

Enhancers for VAT1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G077832 1.1 FANTOM5 Ensembl ENCODE 11.4 +45.7 45743 3.0 JUND GATA2 JUN FOS ZNF24 VAT1L CLEC3A ENSG00000278926 ENSG00000261330
GH16G077966 0.9 ENCODE 10.5 +178.9 178908 3.4 PKNOX1 NFIB GLI4 FEZF1 RAD21 YY1 HSF1 ZNF143 THAP11 MIXL1 CLEC3A WWOX NUDT7 VAT1L LOC105371351
GH16G077990 0.9 Ensembl ENCODE 10.3 +204.5 204523 4.6 ZNF133 MNT CHD7 JUND POLR2A ZNF239 POU5F1 FOS FOSL2 CLEC3A VAT1L WWOX LOC105371351
GH16G077961 0.9 ENCODE 10.2 +174.3 174294 3.6 PKNOX1 FOXA2 MLX WRNIP1 RARA CBX5 FOS ETV6 RCOR1 CREM CLEC3A NUDT7 VAT1L WWOX LOC105371351
GH16G077676 0.8 ENCODE 10.5 -112.6 -112602 0.2 CTCF ZNF792 RB1 WRNIP1 ZSCAN9 RAD21 ZSCAN5C ZNF143 SMC3 MIXL1 NUDT7 VAT1L CLEC3A WWOX ENSG00000278862
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAT1L on UCSC Golden Path with GeneCards custom track

Promoters for VAT1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088125 70 401 ARNT RAD21 ZBTB40 YY1 SCRT2 ZNF143 EGR2 ZEB2 ZNF579 NFIC

Genomic Location for VAT1L Gene

Chromosome:
16
Start:
77,788,530 bp from pter
End:
77,980,107 bp from pter
Size:
191,578 bases
Orientation:
Plus strand

Genomic View for VAT1L Gene

Genes around VAT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAT1L Gene

Proteins for VAT1L Gene

  • Protein details for VAT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCJ6-VAT1L_HUMAN
    Recommended name:
    Synaptic vesicle membrane protein VAT-1 homolog-like
    Protein Accession:
    Q9HCJ6
    Secondary Accessions:
    • Q8IYW8

    Protein attributes for VAT1L Gene

    Size:
    419 amino acids
    Molecular mass:
    45899 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13402.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAT1L Gene

neXtProt entry for VAT1L Gene

Post-translational modifications for VAT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAT1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAT1L Gene

Domains & Families for VAT1L Gene

Suggested Antigen Peptide Sequences for VAT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCJ6

UniProtKB/Swiss-Prot:

VAT1L_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with VAT1L: view

No data available for Gene Families for VAT1L Gene

Function for VAT1L Gene

Enzyme Numbers (IUBMB) for VAT1L Gene

Gene Ontology (GO) - Molecular Function for VAT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with VAT1L: view
genes like me logo Genes that share phenotypes with VAT1L: view

Animal Models for VAT1L Gene

MGI Knock Outs for VAT1L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAT1L Gene

Localization for VAT1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAT1L gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VAT1L Gene

Pathways & Interactions for VAT1L Gene

SuperPathways for VAT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for VAT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with VAT1L: view

No data available for Pathways by source and SIGNOR curated interactions for VAT1L Gene

Drugs & Compounds for VAT1L Gene

(1) Drugs for VAT1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma 0

(5) Additional Compounds for VAT1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Propyl alcohol
  • 1-Hydroxypropane
  • 1-Propanol
  • 1-Propyl alcohol
  • Ethylcarbinol
  • Hydroxypropane
71-23-8
genes like me logo Genes that share compounds with VAT1L: view

Transcripts for VAT1L Gene

mRNA/cDNA for VAT1L Gene

Unigene Clusters for VAT1L Gene

Vesicle amine transport protein 1 homolog (T. californica)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAT1L Gene

No ASD Table

Relevant External Links for VAT1L Gene

GeneLoc Exon Structure for
VAT1L
ECgene alternative splicing isoforms for
VAT1L

Expression for VAT1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAT1L Gene

mRNA differential expression in normal tissues according to GTEx for VAT1L Gene

This gene is overexpressed in Brain - Hypothalamus (x9.5), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Cerebellar Hemisphere (x4.8), Brain - Caudate (basal ganglia) (x4.8), Brain - Cerebellum (x4.7), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for VAT1L Gene

This gene is overexpressed in Retina (38.9) and Spinal cord (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAT1L Gene



Protein tissue co-expression partners for VAT1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VAT1L Gene:

VAT1L

SOURCE GeneReport for Unigene cluster for VAT1L Gene:

Hs.461405

mRNA Expression by UniProt/SwissProt for VAT1L Gene:

Q9HCJ6-VAT1L_HUMAN
Tissue specificity: Detected in skin fibroblasts.

Evidence on tissue expression from TISSUES for VAT1L Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with VAT1L: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VAT1L Gene

Orthologs for VAT1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAT1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAT1L 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia VAT1L 34 35
  • 93.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VAT1L 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAT1L 34 35
  • 91.49 (n)
rat
(Rattus norvegicus)
Mammalia Vat1l 34
  • 90.17 (n)
mouse
(Mus musculus)
Mammalia Vat1l 34 16 35
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia VAT1L 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAT1L 34 35
  • 81.66 (n)
lizard
(Anolis carolinensis)
Reptilia VAT1L 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vat1l 34
  • 77.8 (n)
zebrafish
(Danio rerio)
Actinopterygii vat1l 34 35
  • 73.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006478 34
  • 61.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 35
  • 24 (a)
OneToMany
Species where no ortholog for VAT1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAT1L Gene

ENSEMBL:
Gene Tree for VAT1L (if available)
TreeFam:
Gene Tree for VAT1L (if available)

Paralogs for VAT1L Gene

Paralogs for VAT1L Gene

(4) SIMAP similar genes for VAT1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VAT1L: view

Variants for VAT1L Gene

Sequence variations from dbSNP and Humsavar for VAT1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000007105 -- 77,799,328(+) CCCTT(C/T)TCTCC intron-variant
rs1000015984 -- 77,975,120(+) GTGTC(A/G/T)CTGTC intron-variant
rs1000037090 -- 77,863,871(+) AACCT(A/G)GGTGT intron-variant
rs1000056056 -- 77,925,558(+) TTCAG(C/G/T)TTTCC intron-variant
rs1000079881 -- 77,877,196(+) CATAG(G/T)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAT1L Gene

Variant ID Type Subtype PubMed ID
dgv3031n100 CNV gain 25217958
esv1635984 CNV insertion 17803354
esv1937488 CNV deletion 18987734
esv2618540 CNV insertion 19546169
esv2618898 CNV deletion 19546169
esv2671939 CNV deletion 23128226
esv2714737 CNV deletion 23290073
esv2714738 CNV deletion 23290073
esv2714739 CNV deletion 23290073
esv2760418 CNV gain+loss 21179565
esv2761917 CNV loss 21179565
esv28896 CNV loss 19812545
esv3375898 CNV insertion 20981092
esv3582334 CNV loss 25503493
esv3582335 CNV loss 25503493
esv3639176 CNV loss 21293372
esv3639177 CNV loss 21293372
esv3639178 CNV loss 21293372
esv3639179 CNV loss 21293372
esv3639180 CNV loss 21293372
esv3639181 CNV loss 21293372
esv3639182 CNV loss 21293372
esv3892898 CNV loss 25118596
esv6734 CNV loss 19470904
nsv103420 CNV deletion 16902084
nsv103488 CNV deletion 16902084
nsv1056676 CNV loss 25217958
nsv1057147 CNV gain 25217958
nsv1060655 CNV loss 25217958
nsv1066083 CNV gain 25217958
nsv1160438 CNV deletion 26073780
nsv1887 CNV insertion 18451855
nsv457543 CNV gain 19166990
nsv510422 OTHER sequence alteration 20534489
nsv518329 CNV loss 19592680
nsv528395 CNV gain 19592680
nsv573129 CNV gain 21841781
nsv573130 CNV loss 21841781
nsv833293 CNV gain 17160897
nsv974838 CNV duplication 23825009

Variation tolerance for VAT1L Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAT1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAT1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAT1L Gene

Disorders for VAT1L Gene

Relevant External Links for VAT1L

Genetic Association Database (GAD)
VAT1L
Human Genome Epidemiology (HuGE) Navigator
VAT1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAT1L

No disorders were found for VAT1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAT1L Gene

Publications for VAT1L Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 4 46 64
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for VAT1L Gene

Sources for VAT1L Gene

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