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Aliases & Descriptions for VAT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 1.-.-.- 3 | | FLJ20230 1, 2 | | VATI 1, 2 |
| | | Descriptions |
|---|
| membrane protein of cholinergic synaptic vesicles 2 | | synaptic vesicle membrane protein VAT-1 homolog 2 | | vesicle amine transport protein 1 2 | | vesicle amine transport protein 1 homolog (T. californica) 2 |
|
| | Search outside databases for aliases for VAT1 genePrevious GC identifers: GC17P062358 GC17M043328 GC17M041075 GC17M041539 |
Summaries for VAT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAT1: Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq] Gene Wiki entry for VAT1 |
Genomic Location for VAT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAT1 gene 
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21VAT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M038420:
(about GC identifiers)
Start:
|
38,420,148 bp from pter |
End:
|
38,427,985 bp from pter |
Size:
|
7,838 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010755.15
| Proteins for VAT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536 (See
protein sequence)Recommended Name: Synaptic vesicle membrane protein VAT-1 homolog Size: 393 amino acids; 41920 Da
Secondary accessions: Q13035 Q5BKZ7 Q96A39 Q9BUT8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006364.2
ENSEMBL proteins: ENSP00000326121 ENSP00000347872
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VAT1 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for VAT1: Assays for VAT1: | Protein
Domains/ Families for VAT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99536
ProtoNet protein and cluster: Q99536 2 Blocks protein families: IPB002364 Quinone oxidoreductase/zeta-crystallin IPB013154 Alcohol dehydrogenase GroES-like
UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | Gene Function for VAT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006373
Applied Biosystems Silencer® siRNAs for VAT1
Sigma-Aldrich siRNA and siRNA Panels for VAT1  Sigma-Aldrich shRNA for VAT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006373                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006373                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006373 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006373
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for VAT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055114 | oxidation reduction |
IEA | -- | About this table
|
Drugs & Compounds for VAT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAT1
|
Transcripts for VAT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006373
Sigma-Aldrich siRNA and siRNA Panels for VAT1  Sigma-Aldrich shRNA for VAT1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006373 REFSEQ mRNAs for VAT1 gene: NM_006373.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006373               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006373                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006373                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006373  Additional cDNA sequence: AK097072.1 AK290460.1 AK298536.1 AK315838.1 BC001913.1 BC008725.2 BC014279.2 BC015041.2 BC068489.1 BC090858.1 BT007369.1 CR594124.1 CR613076.1 CR618877.1 CR620205.1 CR622345.1 U18009.1 U25779.1 24/37 DOTS entries (see all 37
): DT.100848141 DT.453255 DT.100753643 DT.100848135 DT.100848117 DT.100848113 DT.100848128 DT.95122928 DT.120905195 DT.100848130 DT.120905128 DT.120905171 DT.100040859 DT.100045675 DT.100848139 DT.120905150 DT.100031858 DT.120905142 DT.120905240 DT.92461733 DT.95122766 DT.95122912 DT.95122921 DT.120905136 24/1090 AceView cDNA sequences (see all 1090
):AL134862 T35596 BU726332 BM993552 AL134977 AA074307 AU130073 BM708151 AU130572 BC008725 BP348955 AA156050 BQ679624 AU130376 BU630544 BQ678035 CA421720 BQ218769 BQ678292 CA393756 BQ446235 AI422343 CA406406 BU180924
highest scoring ESTs for VAT1:U18009 AA334145 AI815606 AL043651 AL516295 AL534921 AL550238 AL550984 AL555940 AL556303 Unigene Cluster for VAT1: Vesicle amine transport protein 1 homolog (T. californica) Hs.514199 [show with all ESTs]Unigene Representative Sequence: NM_006373
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VAT1 (see all 9
)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAT1
2 Ensembl transcripts including schematic representations: ENST00000315674
ENST00000355653
|
Expression for VAT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAT1
1 / 2 / 3 6 probe-sets matching VAT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGTGGGGAGA
SOURCE GeneReport for Unigene cluster: Hs.514199
Expression variation in blood from EXPOLDB for VAT1 |
Orthologs for VAT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAT1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VAT1
ENSEMBL Gene Tree for VAT1 | Paralogs for VAT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAT1 gene
- VAT1L2 TP53I32
|
SNPs/Variants for VAT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAT1 (up to first 250kb)
|
Disorders & Mutations for VAT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604631
|
Medical News for VAT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for VAT1 gene:- Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)2, 3, 4 Smith T.M....King M.C. (1996)
- 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PubMed id 7774926)2, 3, 4 Friedman L.S....King M.-C. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362)3 Harshman K.... Kamb A. (1995)
- A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)3 Miki Y.... Skolnick M.H. (1994)
- The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. (PubMed id 8076819)3 Matoba R....Matsubara K. (1994)
- The search for BRCA1. (PubMed id 7987831)3 Friedman L.S....King M.C. (1994)
|
Search for VAT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAT1:

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| | | | Search Tocris compounds for VAT1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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