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VAT1 Gene

protein-coding   GIFtS: 55
GCID: GC17M041166

Vesicle Amine Transport 1

(Previous name: vesicle amine transport protein 1 homolog (T. californica))
  Search for VAT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vesicle Amine Transport 11 2
Vesicle Amine Transport Protein 1 Homolog (T. Californica)1 2
VATI2
Membrane Protein Of Cholinergic Synaptic Vesicles2
Synaptic Vesicle Membrane Protein VAT-1 Homolog2
EC 1.-.-.-3

External Ids:    HGNC: 169191   Entrez Gene: 104932   Ensembl: ENSG000001088287   OMIM: 6046315   UniProtKB: Q995363   

Export aliases for VAT1 gene to outside databases

Previous GC identifers: GC17P062358 GC17M043328 GC17M041075 GC17M041539 GC17M038420 GC17M036932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAT1 Gene:
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve
terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic
vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily
of zinc-containing alcohol dehydrogenase proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAT1 Gene:
VAT1 (vesicle amine transport 1) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is ZADH2.

UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536
Function: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in
epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in
cooperation with mitofusin proteins (MFN1-2)

Gene Wiki entry for VAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAT1 gene promoter:
         SRF   RP58   AP-1   SRF (504 AA)   Lmo2   N-Myc   MZF-1   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAT1 promoter sequence
   Search Chromatin IP Primers for VAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

VAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041166:  view genomic region     (about GC identifiers)

Start:
41,166,622 bp from pter      End:
41,177,140 bp from pter
Size:
10,519 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536 (See protein sequence)
Recommended Name: Synaptic vesicle membrane protein VAT-1 homolog  
Size: 393 amino acids; 41920 Da
Sequence caution: Sequence=AAC37596.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K345 Q13035 Q5BKZ7 Q96A39 Q9BUT8

Explore the universe of human proteins at neXtProt for VAT1: NX_Q99536

Explore proteomics data for VAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys61, Lys255, Lys271, Lys295, Lys355, Lys372
  • Modification sites at PhosphoSitePlus

  • See VAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006364.2  
    ENSEMBL proteins: 
     ENSP00000347872   ENSP00000465239   ENSP00000465946   ENSP00000408553   ENSP00000468621  
     ENSP00000466322   ENSP00000467131   ENSP00000468146   ENSP00000468401  

    VAT1 Human Recombinant Protein Products:

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    OriGene Purified Protein for VAT1
    OriGene Protein Over-expression Lysate for VAT1
    OriGene MassSpec for VAT1
    OriGene Custom Protein Services for VAT1
    GenScript Custom Purified and Recombinant Proteins Services for VAT1
    Novus Biologicals VAT1 Proteins
    Novus Biologicals VAT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for VAT1
    Cloud-Clone Corp. Proteins for VAT1

     
    Search eBioscience for Proteins for VAT1 

    VAT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for VAT1
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    ThermoFisher Antibodies for VAT1
    LSBio Antibodies in human, mouse, rat for VAT1

    VAT1 Assay Products:

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    GenScript Custom Assay Services for VAT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VAT1
    Cloud-Clone Corp. CLIAs for VAT1
    Search eBioscience for ELISAs for VAT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS
     IPR002085 ADH_SF_Zn-type

    Graphical View of Domain Structure for InterPro Entry Q99536

    ProtoNet protein and cluster: Q99536

    2 Blocks protein domains:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Find genes that share domains with VAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAT1_HUMAN, Q99536
    Function: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in
    epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in
    cooperation with mitofusin proteins (MFN1-2)
    Induction: Increased expression in glioblastomas and on wounding, in basal keratinocytes. This expression is
    calcium ion-dependent

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with VAT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VAT1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAT1

    miRNA
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    miRTarBase miRNAs that target VAT1:
    hsa-mir-335-5p (MIRT016832), hsa-mir-93-5p (MIRT048825)

    Block miRNA regulation of human, mouse, rat VAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAT1 (see all 60):
    hsa-miR-146a hsa-miR-15a hsa-miR-30d hsa-miR-486-3p hsa-miR-449a hsa-miR-218 hsa-miR-4267 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VAT1
    Predesigned siRNA for gene silencing in human, mouse, rat VAT1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for VAT1

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    OriGene clones in human, mouse for VAT1 (see all 7)
    OriGene ORF clones in mouse, rat for VAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VAT1 (NM_006373)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAT1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for VAT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VAT1_HUMAN, Q99536: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is
    localized in the cytoplasm and a small amount is associated with mitochondria (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0016021integral component of membrane TAS8938427
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with VAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VAT1
    Interactions:

        Search GeneGlobe Interaction Network for VAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for VAT1 (Q995363 ENSP000003478724) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    PHLPP2Q6ZVD83, ENSP000003486114I2D: score=2 STRING: ENSP00000348611
    CLN3Q132863I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    TLN1Q9Y4903I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010637negative regulation of mitochondrial fusion IMP17105775
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with VAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAT1

    7 HMDB Compounds for VAT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VAT1 gene: 
    NM_006373.3  

    Unigene Cluster for VAT1:

    Vesicle amine transport protein 1 homolog (T. californica)
    Hs.514199  [show with all ESTs]
    Unigene Representative Sequence: NM_006373
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355653(uc010cyw.1 uc010whk.1 uc002icm.1) ENST00000592388
    ENST00000587173 ENST00000420567 ENST00000587147 ENST00000590924 ENST00000589709
    ENST00000589828 ENST00000587062
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VAT1 (see all 60):
    hsa-miR-146a hsa-miR-15a hsa-miR-30d hsa-miR-486-3p hsa-miR-449a hsa-miR-218 hsa-miR-4267 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VAT1
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    OriGene ORF clones in mouse, rat for VAT1
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    GenScript: all cDNA clones in your preferred vector: VAT1 (NM_006373)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAT1
    Primer
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    OriGene qPCR primer pairs and template standards for VAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for VAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAT1
      QuantiTect SYBR Green Assays in human, mouse, rat VAT1
      QuantiFast Probe-based Assays in human, mouse, rat VAT1

    Additional mRNA sequence: 

    AK097072.1 AK290460.1 AK298536.1 AK315838.1 BC001913.1 BC008725.2 BC014279.2 BC015041.2 
    BC068489.1 BC090858.1 BT007369.1 U18009.1 U25779.1 

    Selected DOTS entries (see all 35):

    DT.100848141  DT.453255  DT.100753643  DT.100848135  DT.100848117  DT.100848113  DT.100848128  DT.95122928 
    DT.120905171  DT.120905128  DT.100040859  DT.100045675  DT.100031858  DT.100848130  DT.100848139  DT.120905150 
    DT.120905195  DT.120905240  DT.92461733  DT.95122766  DT.95122912  DT.95122921  DT.120905136  DT.120905142 

    Selected AceView cDNA sequences (see all 1090):

    BQ679624 BM476188 BM564659 CB216439 AU128682 CR618877 BC001913 CA431463 
    BQ935992 AU130968 BM452933 AU130073 BQ021752 AI869099 BU163962 AA722337 
    T35596 BQ215929 CA421720 AU130376 AW005659 BQ225784 AI302802 CB241616 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                          -     -                                                                     
    SP2:                                -                                                                     
    SP3:        -     -     -     -     -                                                                     
    SP4:                                                                                                      
    SP5:                                                                                -     -               


    ECgene alternative splicing isoforms for VAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGGGAGA
    VAT1 Expression
    About this image


    VAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    VAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514199

    UniProtKB/Swiss-Prot: VAT1_HUMAN, Q99536
    Tissue specificity: Expressed in brain. Also expressed in glioblastoma cells

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    QuantiFast Probe-based Assays in human, mouse, rat VAT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAT1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vat11 , 5 vesicle amine transport protein 1 homolog (T californica)1, 5 86.53(n)1
    91.05(a)1
      11 (65.10 cM)5
    269491  NM_012037.21  NP_036167.11 
     1014587455 
    chicken
    (Gallus gallus)
    Aves VAT11 vesicle amine transport protein 1 homolog (T. californica) 69.27(n)
    68.55(a)
      420009  XM_418130.3  XP_418130.2 
    lizard
    (Anolis carolinensis)
    Reptilia VAT16
    vesicle amine transport 1
    63(a)
    1 ↔ 1
    6(62567645-62603013)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.303612 Xenopus laevis transcribed sequence with moderate similarity more 73.9(n)    48050295 
    zebrafish
    (Danio rerio)
    Actinopterygii vat11 vesicle amine transport protein 1 homolog (T californica) 67.44(n)
    66.76(a)
      368752  NM_001007051.3  NP_001007052.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZTA16
    NADPH-dependent quinone reductase, GFP-tagged prot...
    23(a)
    1 → many
    II(330507-331511) YBR046C


    ENSEMBL Gene Tree for VAT1 (if available)
    TreeFam Gene Tree for VAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAT1 gene
    ZADH22  VAT1L2  CRYZ2  TP53I32  
    4 SIMAP similar genes for VAT1 using alignment to 9 protein entries:     VAT1_HUMAN (see all proteins):
    DKFZp547P162    VAT1L    CRYZ    ZADH2

    Find genes that share paralogs with VAT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAT1 (see all 230)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421871561,2
    --41167026(+) GTCCCA/GGTACA 1 -- ut310--------
    rs1901489991,2
    --41167050(+) ACTGCC/TTTTCA 1 -- ut310--------
    rs10035851,2
    C,F,H--41167086(-) CTTGCA/GGATAT 1 -- ut31 ese37Minor allele frequency- G:0.02MN NS NA WA 810
    rs1511943101,2
    --41167151(+) ACAGAC/TCACGA 1 -- ut310--------
    rs1830809561,2
    --41167291(+) AAGGCA/CCTGGG 1 -- ut310--------
    rs115396321,2
    --41167374(-) AGCAAC/TGAAAA 1 -- ut310--------
    rs1452870481,2
    C--41167398(+) CAAATC/TCAGAG 1 -- ut310--------
    rs797072351,2
    F--41167453(+) ACCTAG/TGGGAG 1 -- ut311Minor allele frequency- T:0.50NA 4
    rs1475656831,2
    --41167595(+) GAGGCA/GGGCAC 1 -- ut310--------
    rs1134592111,2
    C--41167683(+) GCTGAC/TGTTTC 1 -- ut312Minor allele frequency- T:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for VAT1 (41166622 - 41177140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672913CNV Deletion23128226
    nsv457742CNV Loss19166990
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for VAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604631    OMIM disorders: --


    Find genes that share disorders with VAT1           About GenesLikeMe


    Export disorders for VAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAT1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with VAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2, 3 Smith T.M.... King M.-C. (Genome Res. 1996)
    2. 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PubMed id 7774926)1, 2, 3 Friedman L.S....King M.-C. (Genomics 1995)
    3. Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. (PubMed id 19508442)1, 2, 9 Mertsch S.... Senner V. (Neuropathol. Appl. Neurobiol. 2009)
    4. Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function. (PubMed id 17105775)1, 2 Eura Y.... Mihara K. (J. Cell Sci. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10493 HGNC: 16919 AceView: VAT1 Ensembl:ENSG00000108828 euGenes: HUgn10493
    ECgene: VAT1 H-InvDB: VAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VAT1 gene:
    Search GeneIP for patents involving VAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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