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Aliases for VAT1 Gene

Aliases for VAT1 Gene

  • Vesicle Amine Transport 1 2 3
  • Vesicle Amine Transport Protein 1 Homolog (T. Californica) 2 3
  • Membrane Protein Of Cholinergic Synaptic Vesicles 3
  • Synaptic Vesicle Membrane Protein VAT-1 Homolog 3
  • EC 1.-.-.- 4
  • VATI 3

External Ids for VAT1 Gene

Previous GeneCards Identifiers for VAT1 Gene

  • GC17P062358
  • GC17M043328
  • GC17M041075
  • GC17M041539
  • GC17M038420
  • GC17M041166
  • GC17M036932

Summaries for VAT1 Gene

Entrez Gene Summary for VAT1 Gene

  • Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAT1 Gene

VAT1 (Vesicle Amine Transport 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is CRYZ.

UniProtKB/Swiss-Prot for VAT1 Gene

  • Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).

Gene Wiki entry for VAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAT1 Gene

Genomics for VAT1 Gene

Regulatory Elements for VAT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VAT1 Gene

Start:
43,014,605 bp from pter
End:
43,025,123 bp from pter
Size:
10,519 bases
Orientation:
Minus strand

Genomic View for VAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAT1 Gene

Proteins for VAT1 Gene

  • Protein details for VAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99536-VAT1_HUMAN
    Recommended name:
    Synaptic vesicle membrane protein VAT-1 homolog
    Protein Accession:
    Q99536
    Secondary Accessions:
    • A8K345
    • B0AZP7
    • B4DPX4
    • Q13035
    • Q5BKZ7
    • Q96A39
    • Q9BUT8

    Protein attributes for VAT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    41920 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC37596.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for VAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAT1 Gene

Proteomics data for VAT1 Gene at MOPED

Post-translational modifications for VAT1 Gene

  • Ubiquitination at Lys61, Lys255, Lys271, Lys295, Lys355, and Lys372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VAT1 Gene

Domains for VAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99536

UniProtKB/Swiss-Prot:

VAT1_HUMAN :
  • Q99536
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with VAT1: view

No data available for Gene Families for VAT1 Gene

Function for VAT1 Gene

Molecular function for VAT1 Gene

UniProtKB/Swiss-Prot Function: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
UniProtKB/Swiss-Prot Induction: Increased expression in glioblastomas and on wounding, in basal keratinocytes. This expression is calcium ion-dependent.

Enzyme Numbers (IUBMB) for VAT1 Gene

Gene Ontology (GO) - Molecular Function for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with VAT1: view

Phenotypes for VAT1 Gene

GenomeRNAi human phenotypes for VAT1:
genes like me logo Genes that share phenotypes with VAT1: view

Animal Model Products

CRISPR Products

miRNA for VAT1 Gene

miRTarBase miRNAs that target VAT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for VAT1 Gene

Localization for VAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAT1 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAT1 Gene COMPARTMENTS Subcellular localization image for VAT1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane TAS 8938427
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VAT1: view

Pathways for VAT1 Gene

SuperPathways for VAT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010637 negative regulation of mitochondrial fusion IMP 17105775
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with VAT1: view

No data available for Pathways by source for VAT1 Gene

Compounds for VAT1 Gene

(7) HMDB Compounds for VAT1 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Ethanol
  • 1-Hydroxyethane
64-17-5
Isobutanol
  • 1-Hydroxymethylpropane
78-83-1
genes like me logo Genes that share compounds with VAT1: view

Transcripts for VAT1 Gene

Unigene Clusters for VAT1 Gene

Vesicle amine transport protein 1 homolog (T. californica):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -

Relevant External Links for VAT1 Gene

GeneLoc Exon Structure for
VAT1
ECgene alternative splicing isoforms for
VAT1

Expression for VAT1 Gene

mRNA expression in normal human tissues for VAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAT1 Gene

SOURCE GeneReport for Unigene cluster for VAT1 Gene Hs.514199

mRNA Expression by UniProt/SwissProt for VAT1 Gene

Q99536-VAT1_HUMAN
Tissue specificity: Expressed in brain. Also expressed in glioblastoma cells.
genes like me logo Genes that share expressions with VAT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VAT1 Gene

Orthologs for VAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAT1 35
  • 99.24 (n)
  • 98.47 (a)
VAT1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAT1 35
  • 89.21 (n)
  • 92.57 (a)
VAT1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAT1 35
  • 90.91 (n)
  • 94.12 (a)
VAT1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vat1 35
  • 86.53 (n)
  • 91.05 (a)
Vat1 16
Vat1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAT1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAT1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vat1 35
  • 86.62 (n)
  • 90.79 (a)
chicken
(Gallus gallus)
Aves VAT1 35
  • 69.27 (n)
  • 68.55 (a)
VAT1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAT1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30361 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7512 35
vat1 35
  • 67.83 (n)
  • 67.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10896 35
zebrafish
(Danio rerio)
Actinopterygii vat1 35
  • 67.44 (n)
  • 66.76 (a)
vat1 36
  • 51 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 36
  • 23 (a)
OneToMany
Species with no ortholog for VAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAT1 Gene

ENSEMBL:
Gene Tree for VAT1 (if available)
TreeFam:
Gene Tree for VAT1 (if available)

Paralogs for VAT1 Gene

Paralogs for VAT1 Gene

Selected SIMAP similar genes for VAT1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with VAT1: view

Variants for VAT1 Gene

Sequence variations from dbSNP and Humsavar for VAT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs382172 -- 43,016,200(-) CTGGC(C/T)CTTGT intron-variant
rs382173 -- 43,016,198(-) GGCTC(C/T)TGTTG intron-variant
rs382571 -- 43,019,464(+) TGCAG(A/G)CAAAG intron-variant
rs392363 -- 43,017,593(-) ttttt(G/T)gtttt intron-variant
rs406459 -- 43,016,069(-) AGAAG(C/G)AGAAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for VAT1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226

Relevant External Links for VAT1 Gene

HapMap Linkage Disequilibrium report
VAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAT1 Gene

Disorders for VAT1 Gene

No disorders were found for VAT1 Gene.

No data available for UniProtKB/Swiss-Prot for VAT1 Gene

Publications for VAT1 Gene

  1. Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. (PMID: 19508442) Mertsch S. … Senner V. (Neuropathol. Appl. Neurobiol. 2009) 3 4 23
  2. 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PMID: 7774926) Friedman L.S. … King M.-C. (Genomics 1995) 2 3 4
  3. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith T.M. … King M.-C. (Genome Res. 1996) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for VAT1 Gene

Sources for VAT1 Gene

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