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Aliases for VAT1 Gene

Aliases for VAT1 Gene

  • Vesicle Amine Transport 1 2 3 5
  • Vesicle Amine Transport Protein 1 Homolog (T. Californica) 2 3
  • Membrane Protein Of Cholinergic Synaptic Vesicles 3
  • Synaptic Vesicle Membrane Protein VAT-1 Homolog 3
  • EC 1.-.-.- 4
  • VATI 3

External Ids for VAT1 Gene

Previous GeneCards Identifiers for VAT1 Gene

  • GC17P062358
  • GC17M043328
  • GC17M041075
  • GC17M041539
  • GC17M038420
  • GC17M041166
  • GC17M036932

Summaries for VAT1 Gene

Entrez Gene Summary for VAT1 Gene

  • Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAT1 Gene

VAT1 (Vesicle Amine Transport 1) is a Protein Coding gene. Diseases associated with VAT1 include Immature Cataract. Among its related pathways are Immune System. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is VAT1L.

UniProtKB/Swiss-Prot for VAT1 Gene

  • Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).

Gene Wiki entry for VAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAT1 Gene

Genomics for VAT1 Gene

Regulatory Elements for VAT1 Gene

Enhancers for VAT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043124 0.2 ENCODE 12.1 -100.5 -100482 2.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NBR2 DHX8 LINC00910 HMGN1P29 ENSG00000267758 ENSG00000267002 HSD17B1 VAT1 RND2 ENSG00000267340
GH17F043079 1.2 FANTOM5 ENCODE 11.9 -55.4 -55386 2.7 SCRT1 HLF SCRT2 ZNF384 ZIC2 NBR2 RND2 VAT1 RPL27 PTGES3L-AARSD1 PSMC3IP BRCA1 GC17P043187 GC17P043307
GH17F043215 0.2 ENCODE 11.4 -192.3 -192310 3.9 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 PAF1 MXD4 MIER2 REST NBR2 RND2 VAT1 TMEM106A RNU2-1
GH17F043309 1.2 Ensembl ENCODE 11.2 -284.9 -284905 1.1 WRNIP1 ARID4B SIN3A ZNF121 ZNF143 DEK ZNF263 REST KAT8 SSRP1 NBR2 RND2 VAT1 LINC00854 GC17P043358
GH17F043314 1 Ensembl ENCODE 11.2 -291.0 -290978 3.0 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 ZNF207 NBR2 NBR1 LOC108783654 TUBG2 RND2 VAT1 ENSG00000260793 ENSG00000267002 ENSG00000267765 PTGES3L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VAT1 on UCSC Golden Path with GeneCards custom track

Promoters for VAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346753 123 1601 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for VAT1 Gene

Chromosome:
17
Start:
43,014,605 bp from pter
End:
43,025,123 bp from pter
Size:
10,519 bases
Orientation:
Minus strand

Genomic View for VAT1 Gene

Genes around VAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAT1 Gene

Proteins for VAT1 Gene

  • Protein details for VAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99536-VAT1_HUMAN
    Recommended name:
    Synaptic vesicle membrane protein VAT-1 homolog
    Protein Accession:
    Q99536
    Secondary Accessions:
    • A8K345
    • B0AZP7
    • B4DPX4
    • Q13035
    • Q5BKZ7
    • Q96A39
    • Q9BUT8

    Protein attributes for VAT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    41920 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC37596.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for VAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAT1 Gene

Post-translational modifications for VAT1 Gene

  • Ubiquitination at Lys 61, Lys 255, Lys 271, Lys 295, Lys 355, and Lys 372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VAT1 Gene

Domains & Families for VAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99536

UniProtKB/Swiss-Prot:

VAT1_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with VAT1: view

No data available for Gene Families for VAT1 Gene

Function for VAT1 Gene

Molecular function for VAT1 Gene

UniProtKB/Swiss-Prot Function:
Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
UniProtKB/Swiss-Prot Induction:
Increased expression in glioblastomas and on wounding, in basal keratinocytes. This expression is calcium ion-dependent.

Enzyme Numbers (IUBMB) for VAT1 Gene

Gene Ontology (GO) - Molecular Function for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with VAT1: view
genes like me logo Genes that share phenotypes with VAT1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAT1 Gene

Localization for VAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAT1 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAT1 Gene COMPARTMENTS Subcellular localization image for VAT1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 8938427
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VAT1: view

Pathways & Interactions for VAT1 Gene

SuperPathways for VAT1 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with VAT1: view

Pathways by source for VAT1 Gene

2 Reactome pathways for VAT1 Gene

Gene Ontology (GO) - Biological Process for VAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010637 negative regulation of mitochondrial fusion IMP 17105775
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with VAT1: view

No data available for SIGNOR curated interactions for VAT1 Gene

Drugs & Compounds for VAT1 Gene

(1) Drugs for VAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma 0

(5) Additional Compounds for VAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Propyl alcohol
  • 1-Hydroxypropane
  • 1-Propanol
  • 1-Propyl alcohol
  • Ethylcarbinol
  • Hydroxypropane
71-23-8
genes like me logo Genes that share compounds with VAT1: view

Transcripts for VAT1 Gene

Unigene Clusters for VAT1 Gene

Vesicle amine transport protein 1 homolog (T. californica):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -

Relevant External Links for VAT1 Gene

GeneLoc Exon Structure for
VAT1
ECgene alternative splicing isoforms for
VAT1

Expression for VAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAT1 Gene

This gene is overexpressed in Adrenal (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAT1 Gene



Protein tissue co-expression partners for VAT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VAT1 Gene:

VAT1

SOURCE GeneReport for Unigene cluster for VAT1 Gene:

Hs.514199

mRNA Expression by UniProt/SwissProt for VAT1 Gene:

Q99536-VAT1_HUMAN
Tissue specificity: Expressed in brain. Also expressed in glioblastoma cells.
genes like me logo Genes that share expression patterns with VAT1: view

Primer Products

No data available for mRNA differential expression in normal tissues for VAT1 Gene

Orthologs for VAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAT1 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia VAT1 34 35
  • 90.91 (n)
cow
(Bos Taurus)
Mammalia VAT1 34 35
  • 89.21 (n)
rat
(Rattus norvegicus)
Mammalia Vat1 34
  • 86.62 (n)
mouse
(Mus musculus)
Mammalia Vat1 34 16 35
  • 86.53 (n)
oppossum
(Monodelphis domestica)
Mammalia VAT1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAT1 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAT1 34 35
  • 69.27 (n)
lizard
(Anolis carolinensis)
Reptilia VAT1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vat1 34
  • 67.83 (n)
Str.7512 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30361 34
zebrafish
(Danio rerio)
Actinopterygii vat1 34 35
  • 67.44 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10896 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 35
  • 23 (a)
OneToMany
Species where no ortholog for VAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAT1 Gene

ENSEMBL:
Gene Tree for VAT1 (if available)
TreeFam:
Gene Tree for VAT1 (if available)

Paralogs for VAT1 Gene

Paralogs for VAT1 Gene

genes like me logo Genes that share paralogs with VAT1: view

Variants for VAT1 Gene

Sequence variations from dbSNP and Humsavar for VAT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1003585 -- 43,015,069(-) CTTGC(A/G)GATAT utr-variant-3-prime
rs1048299 -- 43,014,234(+) AGGTA(A/G)AGGCC downstream-variant-500B, reference, missense
rs1048323 -- 43,014,286(+) CACCT(C/T)TGAGT downstream-variant-500B, reference, missense
rs1057453 -- 43,014,714(-) ATTGT(C/T)TAAAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1057462 -- 43,014,681(-) GATTT(C/T)TGCTT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VAT1 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457742 CNV loss 19166990
nsv575052 CNV loss 21841781

Variation tolerance for VAT1 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAT1 Gene

Disorders for VAT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VAT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
immature cataract
  • incipient cataract
- elite association - COSMIC cancer census association via MalaCards
Search VAT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAT1
genes like me logo Genes that share disorders with VAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAT1 Gene

Publications for VAT1 Gene

  1. Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. (PMID: 19508442) Mertsch S. … Senner V. (Neuropathol. Appl. Neurobiol. 2009) 3 4 22 64
  2. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith T.M. … King M.-C. (Genome Res. 1996) 2 3 4 64
  3. 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PMID: 7774926) Friedman L.S. … King M.-C. (Genomics 1995) 2 3 4 64
  4. Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function. (PMID: 17105775) Eura Y. … Mihara K. (J. Cell Sci. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for VAT1 Gene

Sources for VAT1 Gene

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