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VASP Gene

protein-coding   GIFtS: 68
GCID: GC19P046010

Vasodilator-Stimulated Phosphoprotein

  See VASP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vasodilator-Stimulated Phosphoprotein1 2

External Ids:    HGNC: 126521   Entrez Gene: 74082   Ensembl: ENSG000001257537   OMIM: 6017035   UniProtKB: P505523   

Export aliases for VASP gene to outside databases

Previous GC identifers: GC19P046654 GC19P046401 GC19P050686 GC19P050702 GC19P042440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VASP Gene:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members
contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP
proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that
binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both
G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell
adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate
integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and
PKG. (provided by RefSeq, Jul 2008)

GeneCards Summary for VASP Gene:
VASP (vasodilator-stimulated phosphoprotein) is a protein-coding gene. Diseases associated with VASP include shigellosis. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is SPRED3.

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552
Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet
activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing
actin filaments against capping and increases the rate of actin polymerization in the presence of capping
protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers
onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in
host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation

Gene Wiki entry for VASP (Vasodilator-stimulated phosphoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VASP gene promoter:
         CREB   NRSF form 1   deltaCREB   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVASP promoter sequence
   Search Chromatin IP Primers for VASP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VASP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

VASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VASP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046010:  view genomic region     (about GC identifiers)

Start:
46,009,837 bp from pter      End:
46,030,241 bp from pter
Size:
20,405 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 (See protein sequence)
Recommended Name: Vasodilator-stimulated phosphoprotein  
Size: 380 amino acids; 39830 Da
Subunit: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the
Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of
actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of
Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3
domain of DNMBP (By similarity). Interacts weakly with MEFV
Miscellaneous: VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce
platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients at risk for
these problems
Selected PDB 3D structures from and Proteopedia for VASP (see all 7):
1EGX (3D)        1JNG (3D)        1USD (3D)        1USE (3D)        2PAV (3D)        2PBD (3D)    
Secondary accessions: B2RBT9 Q6PIZ1 Q93035

Explore the universe of human proteins at neXtProt for VASP: NX_P50552

Explore proteomics data for VASP at MOPED

Post-translational modifications: 

  • Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site
    for PKA is Ser-157, the preferred site for PKG/PRKG1, Ser-239. In ADP-activated platelets, phosphorylation by PKA
    or PKG on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior
    phosphorylation on Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by
    PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-278 by AMPK does
    not require prior phosphorylation at Ser-157 or Ser-239. Phosphorylation at Ser-157 by PKA is required for
    localization to the tight junctions in epithelial cells. Phosphorylation modulates F-actin binding, actin
    filament elongation and platelet activation. Phosphorylation at Ser-322 by AMPK also alters actin filament
    binding. Carbon monoxide (CO) promotes phosphorylation at Ser-157, while nitric oxide (NO) promotes
    phosphorylation at Ser-157, but also at Ser-239. Response to NO and CO is blunted in platelets from diabetic
    patients, and VASP is not phosphorylated efficiently at Ser-157 and Ser-2391
  • Ubiquitination2 at Lys71
  • Modification sites at PhosphoSitePlus

  • See VASP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003361.1  
    ENSEMBL proteins: 
     ENSP00000467061   ENSP00000245932   ENSP00000464742   ENSP00000467773   ENSP00000467005  
     ENSP00000466319  
    Reactome Protein details: P50552

    VASP Human Recombinant Protein Products:

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    VASP Assay Products:

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    Search eBioscience for ELISAs for VASP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017354 Vasodilator_phosphoprotein
     IPR011993 PH_like_dom
     IPR014885 VASP_tetra
     IPR000697 WH1/EVH1

    Graphical View of Domain Structure for InterPro Entry P50552

    ProtoNet protein and cluster: P50552

    UniProtKB/Swiss-Prot: VASP_HUMAN, P50552
    Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding.
    The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is
    required for F-actin binding and subcellular location, and Block C for tetramerization
    Domain: The WH1 domain mediates interaction with XIRP1
    Similarity: Belongs to the Ena/VASP family
    Similarity: Contains 1 WH1 domain


    Find genes that share domains with VASP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VASP_HUMAN, P50552
    Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
    cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet
    activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing
    actin filaments against capping and increases the rate of actin polymerization in the presence of capping
    protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers
    onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in
    host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation

         Genatlas biochemistry entry for VASP:
    vasodilator-stimulated phosphoprotein,expressed in platelets and a wide variety of other cells,associated with
    actin filaments and focal adhesions which form the interface between cytoskeleton and extracellular
    matrix,involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI16940418
    GO:0005522profilin binding IPI17914456
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with VASP           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vasp):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  mortality/aging 
     nervous system 

    Find genes that share phenotypes with VASP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VASP: Vasptm1Mzim Vasptm1Ref

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VASP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VASP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VASP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VASP

    miRNA
    Products:
        
    miRTarBase miRNAs that target VASP:
    hsa-mir-1 (MIRT023600), hsa-mir-610 (MIRT006292), hsa-mir-330-5p (MIRT038256), hsa-mir-3615 (MIRT052857), hsa-mir-193b-3p (MIRT016406)

    Block miRNA regulation of human, mouse, rat VASP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VASP (see all 26):
    hsa-miR-3910 hsa-miR-4291 hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-548a-3p hsa-miR-1323 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidVASP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VASP
    Predesigned siRNA for gene silencing in human, mouse, rat VASP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VASP

    Clone
    Products:
         
    OriGene clones in human, mouse for VASP (see all 7)
    OriGene ORF clones in mouse, rat for VASP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VASP (NM_003370)
    Sino Biological Human cDNA Clone for VASP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VASP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VASP

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VASP_HUMAN, P50552: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight
    junction (By similarity). Cell projection, lamellipodium membrane. Cell projection, filopodium membrane.
    Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL
    family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by
    thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments
    throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in
    large specks (pyroptosomes)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IDA--
    GO:0005923tight junction IEA--

    Find genes that share ontologies with VASP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VASP About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Cell junction organization
    Cell junction organization0.70
    Cell-extracellular matrix interactions0.00
    Cell-Cell communication0.64
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    Activation of PKA through GPCR0.71
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5TCR signaling (REACTOME)
    TCR signaling0.73


    Find genes that share SuperPaths with VASP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VASP
        Activation of PKA through GPCR
    PKA Signaling
    Epithelial Tight Junctions
    Activation of cAMP-Dependent PKA
    Actin Nucleation by ARP-WASP Complex

    1 Cell Signaling Technology (CST) Pathway for VASP
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for VASP
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

    4 BioSystems Pathways for VASP
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in keratinocytes
    Stabilization and expansion of the E-cadherin adherens junction


    3 Reactome Pathways for VASP
        Cell-extracellular matrix interactions
    Signaling by Robo receptor
    Generation of second messenger molecules


    4 Kegg Pathways  (Kegg details for VASP):
        Rap1 signaling pathway
    Focal adhesion
    Fc gamma R-mediated phagocytosis
    Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VASP: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VASP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VASP (P505521, 2, 3 ENSP000002459324) via UniProtKB, MINT, STRING, and/or I2D (see all 747)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSMAFQ926361, 2, 3, ENSP000004110124EBI-748201,EBI-2947053 MINT-5115772 MINT-5115793 I2D: score=1 STRING: ENSP00000411012
    TRIM9Q9C0262, 3, ENSP000002983554MINT-67679 I2D: score=4 STRING: ENSP00000298355
    ACTG1P632612, 3, ENSP000003315144MINT-7899812 I2D: score=2 STRING: ENSP00000331514
    APBB1IPQ7Z5R62, 3, ENSP000003654114MINT-7945693 I2D: score=2 STRING: ENSP00000365411
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0007411axon guidance TAS--
    GO:0008154actin polymerization or depolymerization IEA--
    GO:0030036actin cytoskeleton organization ----
    GO:0030838positive regulation of actin filament polymerization IDA--

    Find genes that share ontologies with VASP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VASP

    1 HMDB Compound for VASP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for VASP gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clopidogrel 82 56 18217157 (5), 15634270 (4), 18387444 (4), 15583724 (3) (see all 24)
    prasugrel 81.7 5 18217157 (3), 19025429 (1), 19435740 (1)
    cgmp 69.9 76 12576312 (6), 10710123 (4), 1315268 (3), 18079117 (3) (see all 26)
    pge1 56.1 23 18832777 (4), 1713458 (2), 2154470 (2), 1315268 (1) (see all 8)
    adp 55.8 29 18832777 (3), 18022387 (2), 17482663 (2), 10446085 (2) (see all 13)
    kt 5823 54 5 10922374 (3), 12576312 (1)
    sodium nitroprusside 46.5 14 2154470 (2), 1315268 (1), 7980622 (1), 16360131 (1) (see all 8)
    aspirin 46.2 5 19135705 (2), 17635731 (1), 19652892 (1)
    forskolin 42.9 5 15381390 (1), 14602552 (1), 16973907 (1), 7925440 (1) (see all 5)
    kt 5720 42 2 12576312 (1), 11313394 (1)



    Find genes that share compounds with VASP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VASP gene (2 alternative transcripts): 
    NM_003370.3  NM_001008736.1  

    Unigene Cluster for VASP:

    Vasodilator-stimulated phosphoprotein
    Hs.515469  [show with all ESTs]
    Unigene Representative Sequence: NM_003370
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589627 ENST00000245932(uc002pcg.3 uc002pci.3) ENST00000592139
    ENST00000590603 ENST00000586014 ENST00000586619 ENST00000588482 ENST00000590459
    ENST00000588463 ENST00000588273 ENST00000587444
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VASP (see all 26):
    hsa-miR-3910 hsa-miR-4291 hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-548a-3p hsa-miR-1323 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidVASP 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: VASP (NM_003370)
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      QuantiTect SYBR Green Assays in human, mouse, rat VASP
      QuantiFast Probe-based Assays in human, mouse, rat VASP

    Additional mRNA sequence: 

    AK314812.1 BC026019.1 BC038224.1 Z46389.1 

    18 DOTS entries:

    DT.99938233  DT.87017206  DT.100795570  DT.97859810  DT.95258746  DT.100038079  DT.121499781  DT.40305661 
    DT.75107009  DT.91758247  DT.100766382  DT.100795577  DT.40118443  DT.95148695  DT.97812970  DT.97859811 
    DT.91691180  DT.95258763 

    Selected AceView cDNA sequences (see all 341):

    BU160228 BM893785 BM795110 AU280375 CR615417 BM832076 AA748592 BG758775 
    BM893946 BI770480 BQ646752 BG745679 BF515553 AL041942 AW002482 AI694796 
    BM909517 BX344543 Z46389 BF062596 AI493947 AI540053 BQ889895 AL544323 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VASP (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                  -           -                     
    SP2:                                            -     -     -     -                                   -           -                     
    SP3:                                                                                                  -           -                     
    SP4:                                                                                                  -                                 
    SP5:        -     -                                                                                                                     


    ECgene alternative splicing isoforms for VASP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    VASP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCCGGA
    VASP Expression
    About this image


    VASP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; non-germinal center cells   
     
     Epithelial Cells (Uncategorized)
             tonsil ; squamous epithelial cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
    VASP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VASP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515469

    UniProtKB/Swiss-Prot: VASP_HUMAN, P50552
    Tissue specificity: Highly expressed in platelets

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VASP: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VASP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vasp1 , 5 vasodilator-stimulated phosphoprotein1, 5 86.39(n)1
    87.4(a)1
      7 (9.51 cM)5
    223231  NM_001282022.11  NP_001268951.11 
     192569295 
    lizard
    (Anolis carolinensis)
    Reptilia VASP6
    vasodilator-stimulated phosphoprotein
    79(a)
    1 ↔ 1
    AAWZ02038402(306-6820)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.234462 Xenopus laevis transcribed sequence with weak similarity more 75.35(n)    BU915668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vasp6
    VASP (2 of 2)6
    vasodilator-stimulated phosphoprotein
    53(a)
    46(a)
    many → 1
    many → 1
    18(39059004-39153445) ENSDARG00000017105
    10(1939-19705) ENSDARG00000059110
    fruit fly
    (Drosophila melanogaster)
    Insecta ena3 axon guidance actin binding 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-346
    Protein UNC-34, isoform a
    24(a)
    1 → many
    V(982534-995404) WBGene00006770
    barley
    (Hordeum vulgare)
    Liliopsida BF267187.22   -- 77.85(n)    BF267187.2 


    ENSEMBL Gene Tree for VASP (if available)
    TreeFam Gene Tree for VASP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VASP gene
    SPRED32  ENAH2  SPRED12  EVL2  SPRED22  
    1 SIMAP similar gene for VASP using alignment to 6 protein entries:     VASP_HUMAN (see all proteins):
    EVL

    Find genes that share paralogs with VASP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VASP (see all 515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826926641,2
    --46008777(+) AGGATA/CGAATG 1 -- us2k10--------
    rs762980621,2
    C,F--46008803(+) ACTGCG/ACTCCG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1882081831,2
    --46008907(+) CCACCC/TCTCCT 1 -- us2k10--------
    rs32163501,2
    C--46009239(+) GCTACT/-TTAGG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1406045231,2
    --46009330(+) GGTGAC/TAGCGA 1 -- us2k10--------
    rs607205341,2
    C--46009348(+) AAAAA-/AGAAAA 1 -- us2k10--------
    rs22386881,2
    C,F,H--46009520(+) AGGATG/CACGTG 1 -- us2k118Minor allele frequency- C:0.14EA NS NA CSA WA 2128
    rs284879501,2
    C,F,H--46009613(+) CTCACA/GTAGTC 1 -- us2k17Minor allele frequency- G:0.04NS NA 890
    rs1479333331,2
    C--46009634(+) GAGAA-/TTGTTGGT 1 -- us2k10--------
    rs1927914811,2
    --46009661(+) TTGGTA/GGCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VASP (46009837 - 46030241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VASP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912156CNV Loss21882294
    dgv3953n71CNV Loss21882294
    nsv833848CNV Loss17160897
    nsv912154CNV Loss21882294
    nsv912155CNV Loss21882294
    nsv523694CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VASP
    DNA2.0 Custom Variant and Variant Library Synthesis for VASP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601703    OMIM disorders: --

    1 disease for VASP:    
    About MalaCards
    shigellosis

    1 disease from the University of Copenhagen DISEASES database for VASP:
    Coronary heart disease

    Find genes that share disorders with VASP           About GenesLikeMe

    8 Novoseek inferred disease relationships for VASP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 53.5 1 12023040 (1)
    shigellosis 26.3 1 10021367 (1)
    tumors 3.47 1 20307526 (1)
    cardiovascular diseases 0 1 15634270 (1)
    inflammation 0 2 16480498 (2)
    breast cancer 0 2 18813837 (6), 19171136 (1)
    metastasis 0 1 18813837 (1)
    cancer 0 1 18357390 (1)


    Export disorders for VASP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VASP gene, integrated from 10 sources (see all 260):
    (articles sorted by number of sources associating them with VASP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. (PubMed id 8812448)1, 2, 3, 9 Zimmer M....Walter U. (Genomics 1996)
    2. Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. (PubMed id 7828592)1, 2, 9 Haffner C....Walter U. (EMBO J. 1995)
    3. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. (PubMed id 7737110)1, 2, 9 Reinhard M.... Walter U. (EMBO J. 1995)
    4. cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. (PubMed id 8182057)1, 2, 9 Butt E.... Walter U. (J. Biol. Chem. 1994)
    5. Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. (PubMed id 16197368)1, 2, 9 Wentworth J.K.... Poole A.W. (Biochem. J. 2006)
    6. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (PubMed id 15939738)1, 2, 9 Barzik M.... Schafer D.A. (J. Biol. Chem. 2005)
    7. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. (PubMed id 18559661)1, 2, 9 Li Calzi S.... Grant M.B. (Diabetes 2008)
    8. Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. (PubMed id 7925440)1, 2, 9 Horstrup K....Walter U. (Eur. J. Biochem. 1994)
    9. The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (PubMed id 15569942)1, 2, 9 Kuehnel K.... Strelkov S.V. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. (PubMed id 10438535)1, 2, 9 Bachmann C.... Reinhard M. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7408 HGNC: 12652 AceView: VASP Ensembl:ENSG00000125753 euGenes: HUgn7408
    ECgene: VASP Kegg: 7408 H-InvDB: VASP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VASP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VASP gene:
    Search GeneIP for patents involving VASP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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