VASP Gene
protein-coding GIFtS : 64
GCID: GC19 P046010
vasodilator-stimulated phosphoprotein
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor VASP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Vasodilator-Stimulated Phosphoprotein 1 2
Export aliases for VASP gene to outside databases Previous GC identifers: GC19P046654 GC19P046401 GC19P050686 GC19P050702 GC19P042440
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor VASP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for VASP : Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 Function : Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeletonremodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation Gene Wiki entry for VASP (Vasodilator-stimulated phosphoprotein)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor VASP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VASP gene promoter: CREB NRSF form 1 deltaCREB NF-kappaB NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for VASP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VASP
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32 VASP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P046010: view genomic region
(about GC identifiers )
Start:
46,009,837 bp from pter
End:
46,030,241 bp from pter
Size:
20,405 bases
Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor VASP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 (See
protein sequence )Recommended Name: Vasodilator-stimulated phosphoprotein Size : 380 amino acids; 39830 Da
Subunit : Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with thePro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP (By similarity)
Subcellular location : Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, lamellipodiummembrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions
Miscellaneous : VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce plateletreactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients at risk for these problems
6/7 PDB 3D structures from and Proteopedia for VASP (see all 7 ):1EGX (3D)
  1JNG (3D)
  1USD (3D)
  1USE (3D)
  2PAV (3D)
  2PBD (3D)
 
Secondary accessions : B2RBT9 Q6PIZ1 Q93035Explore the universe of human proteins at neXtProt for VASP: NX_P50552 Post-translational modifications:
Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-157, the preferred site for PKG/PRKG1, Ser-239. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior phosphorylation on Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-278 by AMPK does not require prior phosphorylation at Ser-157 or Ser-239. Phosphorylation modulates F-actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-322 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-157, while nitric oxide (NO) promotes phosphorylation at Ser-157, but also at Ser-239. Response to NO and CO is blunted in platelets from diabetic patients, and VASP is not phosphorylated efficiently at Ser-157 and Ser-2391
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P50552 VASP Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_003361.1 ENSEMBL proteins: ENSP00000467061 ENSP00000245932 ENSP00000464742 ENSP00000467773 ENSP00000467005 ENSP00000466319 Reactome Protein details: P50552 Human Recombinant Protein Products: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
VASP for ontologies About GeneDecksing VASP Antibody Products: Assay Products for VASP:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor VASP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
VASP for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P50552 ProtoNet protein and cluster: P50552
UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 Domain : The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. TheKLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization Domain : The WH1 domain mediates interaction with XIRP1Similarity : Belongs to the Ena/VASP familySimilarity : Contains 1 WH1 domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor VASP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 Function : Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeletonremodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation
Genatlas biochemistry entry for VASP : vasodilator-stimulated phosphoprotein,expressed in platelets and a wide variety of other cells,associated with actin filaments and focal adhesions which form the interface between cytoskeleton and extracellular matrix,involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASP (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASPOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VASP (NM_003370 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VASP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASP
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASP
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
VASP for ontologies About GeneDecksing Animal Models: Mouse knock-outs for VASP: Vasp tm1Mzim Vasp tm1Ref 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vasp) :
VASP for phenotypes About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor VASP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/17 super-pathways (see all 17 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Activation of cAMP-Dependent PKA 2 Focal Adhesion 3 Immune System 4 Axon guidance 5 Cell-cell junction organization
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for VASP 5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VASP 1
Cell Signaling Technology (CST) Pathway for VASP 1 GeneGo (Thomson Reuters) Pathway for VASP 4 BioSystems Pathways for VASP 5/10
Reactome Pathways for VASP (see all 10 )3
Kegg Pathways (Kegg details for VASP) :
VASP for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VASP STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/690 Interacting proteins for VASP (P50552 1 , 2 , 3 ENSP00000245932 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 690 )Interactant Interaction Details GeneCard External ID(s) NSMAF Q92636 2 , 3 , ENSP00000411012 4 MINT-5115772 MINT-5115793 I2D:
score=1 STRING: ENSP00000411012 NOL3 O60936 2 , 3 , ENSP00000268605 4 MINT-67223 I2D:
score=5 STRING: ENSP00000268605 TRIM9 Q9C026 2 , 3 , ENSP00000298355 4 MINT-67679 I2D:
score=4 STRING: ENSP00000298355 XPO6 Q96QU8 2 , 3 , ENSP00000302790 4 MINT-7945693 I2D:
score=3 STRING: ENSP00000302790 SPTA1 P02549 2 , 3 , ENSP00000357130 4 MINT-7211723 I2D:
score=2 STRING: ENSP00000357130
About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
VASP for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor VASP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
VASP for compounds About GeneDecksing Browse Tocris compounds for VASP 1 HMDB Compound for VASP About this table 10/25 Novoseek chemical compound relationships for VASP gene (see all 25 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
clopidogrel
82
56
18217157 (5), 15634270 (4), 18387444 (4), 15583724 (3) (see all 24 )
prasugrel
81.7
5
18217157 (3), 19025429 (1), 19435740 (1)
cgmp
69.9
76
12576312 (6), 10710123 (4), 1315268 (3), 18079117 (3) (see all 26 )
pge1
56.1
23
18832777 (4), 1713458 (2), 2154470 (2), 1315268 (1) (see all 8 )
adp
55.8
29
18832777 (3), 18022387 (2), 17482663 (2), 10446085 (2) (see all 13 )
kt 5823
54
5
10922374 (3), 12576312 (1)
sodium nitroprusside
46.5
14
2154470 (2), 1315268 (1), 7980622 (1), 16360131 (1) (see all 8 )
aspirin
46.2
5
19135705 (2), 17635731 (1), 19652892 (1)
forskolin
42.9
5
15381390 (1), 14602552 (1), 16973907 (1), 7925440 (1) (see all 5 )
kt 5720
42
2
12576312 (1), 11313394 (1)
Search CenterWatch for drugs/clinical trials and news about VASP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor VASP gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for VASP gene (2 alternative transcripts): NM_003370.3 NM_001008736.1 Unigene Cluster for VASP:
Vasodilator-stimulated phosphoprotein Hs.515469 [show with all ESTs ] Unigene Representative Sequence: NM_003370 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000589627 ENST00000245932 (uc002pcg.3 uc002pci.3 ) ENST00000592139 ENST00000590603 ENST00000586014 ENST00000586619 ENST00000588482 ENST00000590459 ENST00000588463 ENST00000588273 ENST00000587444 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASP (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASPOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VASP (NM_003370 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VASP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASP
Additional cDNA sequence: AK314812.1 BC026019.1 BC038224.1 Z46389.1
18 DOTS entries : DT.99938233 DT.87017206
DT.100795570 DT.97859810 DT.95258746 DT.100038079 DT.121499781 DT.40305661 DT.75107009 DT.91758247 DT.100766382 DT.100795577 DT.40118443 DT.95148695 DT.97812970 DT.97859811 DT.91691180 DT.95258763 24/341 AceView cDNA sequences (see all 341 ):
AL544323 AI690419 BQ709677 BF515553 AA865383 BI833611 AI493947 BM893946 AL550805 BQ057786 BI770480 BM909517 BM795110 Z46389 AL041942 BE276838 BQ710298 BF516111 AA514402 AA805727 AW002482 BQ889895 BM893785 NM_003370 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VASP (see all 9 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b SP1 :                                 -     -         SP2 :               -   -   -   -             -     -         SP3 :                                 -     -         SP4 :                                 -             SP5 :   -   -                                        
ECgene alternative splicing isoforms for VASP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for VASP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section VASP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGCCCGGA
About this image VASP expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Outflow Tract Heart Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See VASP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VASP SOURCE GeneReport for Unigene cluster: Hs.515469 UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 Tissue specificity : Highly expressed in platelets SABiosciences Expression via Pathway-Focused PCR Arrays including VASP : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VASPBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat VASP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VASP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VASP In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor VASP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for VASP gene from 6/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Vasp1 , 5
vasodilator-stimulated phosphoprotein1, 5
87.38(n) 1 88.8(a) 1
 
7 (9.51 cM) 5 22323 1 NM_009499.2 1 NP_033525.2 1 19256929 5
lizard (Anolis carolinensis)
Reptilia
VASP6
--
79(a)
1 ↔ 1
AAWZ02038402(2382-6769)
African clawed frog (Xenopus laevis)
Amphibia
Xl.234462
Xenopus laevis transcribed sequence with weak similarity more
75.35(n)
 
BU915668.1
zebrafish (Danio rerio)
Actinopterygii
vasp6 zgc:1623206
zgc:162320
52(a) 41(a)
many → 1many → 1
18(39059004-39153445) 10(1939-19705)
fruit fly (Drosophila melanogaster)
Insecta
ena3
axon guidance actin binding
43(a)
 
--
barley (Hordeum vulgare)
Liliopsida
BF267187.22
--
77.85(n)
 
BF267187.2
ENSEMBL Gene Tree for VASP (if available)TreeFam Gene Tree for VASP (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor VASP gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for VASP gene ENAH 2 EVL 2 1 SIMAP similar gene for VASP using alignment to 6 protein entries: VASP_HUMAN (see all proteins ):EVL
VASP for paralogs About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor VASP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for VASP (46009837 - 46030241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for VASP: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VASP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor VASP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
VASP for disorders About GeneDecksing
OMIM gene information: 601703
OMIM disorders : --20 diseases for VASP : About MalaCards wiskott-aldrich syndrome myocardial infarction acute myocardial infarction autoimmune myocarditis shigellosis myocarditis crohn's disease vaccinia breast cancer thrombosis gastric cancer blindness lung cancer prostate cancer sarcoma cerebritis cholesterol hypoxia prostatitis neuronitis 1 disease from the University of Copenhagen DISEASES database for VASP :Coronary heart disease 8 Novoseek disease relationships for VASP gene About this table
Export disorders for VASP gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor VASP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for VASP gene, integrated from 9 sources (see all 245 ): (articles sorted by number of sources associating them with VASP) Utopia : connect your pdf to the dynamic world of online information
Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. (PubMed id 8812448) 1 , 2 , 3, 9 Zimmer M....Walter U. (1996) Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. (PubMed id 7828592) 1 , 2 , 9 Haffner C....Walter U. (1995) The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. (PubMed id 7737110) 1 , 2 , 9 Reinhard M.... Walter U. (1995) cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. (PubMed id 8182057) 1 , 2 , 9 Butt E.... Walter U. (1994) Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. (PubMed id 16197368) 1 , 2 , 9 Wentworth J.K.... Poole A.W. (2006) Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (PubMed id 15939738) 1 , 2 , 9 Barzik M.... Schafer D.A. (2005) Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. (PubMed id 18559661) 1 , 2 , 9 Li Calzi S.... Grant M.B. (2008) Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. (PubMed id 7925440) 1 , 2 , 9 Horstrup K....Walter U. (1994) The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (PubMed id 15569942) 1 , 2 , 9 Kuehnel K.... Strelkov S.V. (2004) The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. (PubMed id 10438535) 1 , 2 , 9 Bachmann C.... Reinhard M. (1999)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for VASP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing VASP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing VASP gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing VASP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for VASP Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for VASP gene: Search GeneIP for patents involving VASP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor VASP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for VASP OriGene shRNA RFP for VASP OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for VASP OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VASP OriGene Protein Over-expression Lysate for VASP Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for VASP OriGene 3'-UTR Clone for VASP OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASP OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASP Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for VASP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for VASP OriGene Custom Protein Services for VASP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VASP QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VASP QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VASP QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat VASP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VASP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VASP
Antibodies & Assays for VASP  
Search Tocris compounds for VASP
Recombinant Protein for VASP
VASP Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASP
ThermoFisher Antibodies for VASP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASP
Jump to Section...
Aliases for VASP
Databases for VASP
Disorders / Diseases for VASP
Domains / Families for VASP
Drugs / Compounds for VASP
Expression for VASP
Function for VASP
Genomic Views for VASP
Intellectual Property for VASP
Orthologs for VASP
Paralogs for VASP
Pathways / Interactions for VASP
Products for VASP
Proteins for VASP
Publications for VASP
Search Box for VASP
Summaries for VASP
Transcripts for VASP
Variants for VASP
TOP
BOTTOM