Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VASP Gene

Aliases for VASP Gene

  • Vasodilator-Stimulated Phosphoprotein 2 3 5

External Ids for VASP Gene

Previous GeneCards Identifiers for VASP Gene

  • GC19P046654
  • GC19P046401
  • GC19P050686
  • GC19P050702
  • GC19P046010
  • GC19P042440

Summaries for VASP Gene

Entrez Gene Summary for VASP Gene

  • Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

GeneCards Summary for VASP Gene

VASP (Vasodilator-Stimulated Phosphoprotein) is a Protein Coding gene. Diseases associated with VASP include Vaccinia and Clopidogrel Resistance. Among its related pathways are Activation of cAMP-Dependent PKA and Immune System. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is ENAH.

UniProtKB/Swiss-Prot for VASP Gene

  • Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.

Gene Wiki entry for VASP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASP Gene

Genomics for VASP Gene

Regulatory Elements for VASP Gene

Enhancers for VASP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045505 1 FANTOM5 ENCODE 31.4 +1.3 1267 5.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 SLC30A9 VASP PPM1N IRF2BP1 ENSG00000268810 QPCTL LOC105372418 CLASRP BLOC1S3 FBXO46 ZNF296
GH19F045512 1.3 FANTOM5 ENCODE 21.4 +8.2 8217 3.9 HDGF MLX ARID4B DMAP1 ZNF48 ZNF121 ZNF143 KDM4B SP3 SP5 PPM1N VASP DMWD CLASRP MARK4 FOSB BLOC1S3 GIPR GC19P045560
GH19F045465 0.5 FANTOM5 14.3 -41.4 -41359 0.3 ZNF664 CTCF HDGF RAD21 ZBTB7A VASP PPM1N RTN2 RELB FOSB CLASRP GIPR MIR6088
GH19F045510 0.5 FANTOM5 12 +4.6 4590 0.4 BCOR SMARCA5 WRNIP1 CHD4 ZMYM3 TBX21 HDAC2 ZNF580 KDM1A VASP CLASRP FBXO46 ZNF296 GC19P045560
GH19F045567 1.1 Ensembl ENCODE 12 +62.6 62612 2.4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF48 ZBTB40 RAD21 ZEB1 ZNF121 OPA3 VASP RTN2 PPM1N EML2 MIR330 MIR642A ERCC1 CD3EAP PPP1R13L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VASP on UCSC Golden Path with GeneCards custom track

Promoters for VASP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347417 1621 4001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 SLC30A9

Genomic Location for VASP Gene

Chromosome:
19
Start:
45,506,579 bp from pter
End:
45,526,989 bp from pter
Size:
20,411 bases
Orientation:
Plus strand

Genomic View for VASP Gene

Genes around VASP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASP Gene

Proteins for VASP Gene

  • Protein details for VASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50552-VASP_HUMAN
    Recommended name:
    Vasodilator-stimulated phosphoprotein
    Protein Accession:
    P50552
    Secondary Accessions:
    • B2RBT9
    • Q6PIZ1
    • Q93035

    Protein attributes for VASP Gene

    Size:
    380 amino acids
    Molecular mass:
    39830 Da
    Quaternary structure:
    • Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP (By similarity). Interacts weakly with MEFV.
    Miscellaneous:
    • VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients at risk for these problems.

    Three dimensional structures from OCA and Proteopedia for VASP Gene

neXtProt entry for VASP Gene

Post-translational modifications for VASP Gene

  • Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-157, the preferred site for PKG/PRKG1, Ser-239. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior phosphorylation on Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-278 by AMPK does not require prior phosphorylation at Ser-157 or Ser-239. Phosphorylation at Ser-157 by PKA is required for localization to the tight junctions in epithelial cells. Phosphorylation modulates F-actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-322 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-157, while nitric oxide (NO) promotes phosphorylation at Ser-157, but also at Ser-239. Response to NO and CO is blunted in platelets from diabetic patients, and VASP is not phosphorylated efficiently at Ser-157 and Ser-239.
  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VASP Gene

Domains & Families for VASP Gene

Gene Families for VASP Gene

Protein Domains for VASP Gene

Suggested Antigen Peptide Sequences for VASP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50552

UniProtKB/Swiss-Prot:

VASP_HUMAN :
  • The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
  • Belongs to the Ena/VASP family.
Domain:
  • The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
  • The WH1 domain mediates interaction with XIRP1.
  • Contains 1 WH1 domain.
Family:
  • Belongs to the Ena/VASP family.
genes like me logo Genes that share domains with VASP: view

Function for VASP Gene

Molecular function for VASP Gene

GENATLAS Biochemistry:
vasodilator-stimulated phosphoprotein,expressed in platelets and a wide variety of other cells,associated with actin filaments and focal adhesions which form the interface between cytoskeleton and extracellular matrix,involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation
UniProtKB/Swiss-Prot Function:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.

Gene Ontology (GO) - Molecular Function for VASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 8836115
GO:0005522 profilin binding IPI 17914456
GO:0017124 SH3 domain binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with VASP: view
genes like me logo Genes that share phenotypes with VASP: view

Animal Models for VASP Gene

MGI Knock Outs for VASP:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASP Gene

Localization for VASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASP Gene COMPARTMENTS Subcellular localization image for VASP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with VASP: view

Pathways & Interactions for VASP Gene

genes like me logo Genes that share pathways with VASP: view

SIGNOR curated interactions for VASP Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for VASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0007411 axon guidance TAS --
GO:0008154 actin polymerization or depolymerization IEA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0030838 positive regulation of actin filament polymerization IDA 23153535
genes like me logo Genes that share ontologies with VASP: view

Drugs & Compounds for VASP Gene

(21) Drugs for VASP Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clopidogrel Approved Nutra P2Y12 receptor antagonist 756
cyclic amp Experimental Pharma 0
Neurotransmitter Agents Pharma 17734
Platelet Aggregation Inhibitors Pharma 2419
Purinergic P2 Receptor Antagonists Pharma 769

(8) Additional Compounds for VASP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VASP: view

Transcripts for VASP Gene

Unigene Clusters for VASP Gene

Vasodilator-stimulated phosphoprotein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - -

Relevant External Links for VASP Gene

GeneLoc Exon Structure for
VASP
ECgene alternative splicing isoforms for
VASP

Expression for VASP Gene

mRNA expression in normal human tissues for VASP Gene

mRNA differential expression in normal tissues according to GTEx for VASP Gene

This gene is overexpressed in Whole Blood (x16.1).

Protein differential expression in normal tissues from HIPED for VASP Gene

This gene is overexpressed in Platelet (14.2) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VASP Gene



Protein tissue co-expression partners for VASP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VASP Gene:

VASP

SOURCE GeneReport for Unigene cluster for VASP Gene:

Hs.515469

mRNA Expression by UniProt/SwissProt for VASP Gene:

P50552-VASP_HUMAN
Tissue specificity: Highly expressed in platelets.
genes like me logo Genes that share expression patterns with VASP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for VASP Gene

Orthologs for VASP Gene

This gene was present in the common ancestor of animals.

Orthologs for VASP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VASP 34 35
  • 88.04 (n)
cow
(Bos Taurus)
Mammalia VASP 34 35
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Vasp 34 16 35
  • 86.39 (n)
rat
(Rattus norvegicus)
Mammalia Vasp 34
  • 85.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia VASP 35
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23446 34
zebrafish
(Danio rerio)
Actinopterygii vasp 35
  • 53 (a)
OneToMany
VASP (2 of 2) 35
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ena 36 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-34 35
  • 24 (a)
OneToMany
Species where no ortholog for VASP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VASP Gene

ENSEMBL:
Gene Tree for VASP (if available)
TreeFam:
Gene Tree for VASP (if available)

Paralogs for VASP Gene

Paralogs for VASP Gene

(1) SIMAP similar genes for VASP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with VASP: view

Variants for VASP Gene

Sequence variations from dbSNP and Humsavar for VASP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10156 -- 45,526,723(+) TGAGA(C/T)ATCCC utr-variant-3-prime
rs10406351 -- 45,508,080(+) CGACT(C/T)CCCGC intron-variant, upstream-variant-2KB
rs10415373 -- 45,518,061(+) TTGCC(A/G)CCGGC reference, missense
rs10417066 -- 45,520,293(+) gactg(A/G)gactc intron-variant
rs10423254 -- 45,520,701(+) gctca(C/T)gcctg intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VASP Gene

Variant ID Type Subtype PubMed ID
nsv477107 CNV novel sequence insertion 20440878
nsv523694 CNV loss 19592680
nsv833848 CNV loss 17160897

Variation tolerance for VASP Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASP Gene

Disorders for VASP Gene

MalaCards: The human disease database

(2) MalaCards diseases for VASP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards
Search VASP in MalaCards View complete list of genes associated with diseases

Relevant External Links for VASP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASP
genes like me logo Genes that share disorders with VASP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VASP Gene

Publications for VASP Gene

  1. Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. (PMID: 8812448) Zimmer M. … Walter U. (Genomics 1996) 2 3 4 22 64
  2. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. (PMID: 18559661) Li Calzi S. … Grant M.B. (Diabetes 2008) 3 4 22 64
  3. Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. (PMID: 16197368) Wentworth J.K. … Poole A.W. (Biochem. J. 2006) 3 4 22 64
  4. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (PMID: 15939738) Barzik M. … Schafer D.A. (J. Biol. Chem. 2005) 3 4 22 64
  5. The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (PMID: 15569942) Kuehnel K. … Strelkov S.V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64

Products for VASP Gene

Sources for VASP Gene

Content
Loading form....