V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

VASP Gene

protein-coding GIFtS: 63

GC19P050702

vasodilator-stimulated phosphoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
vasodilator-stimulated phosphoprotein ^²

External Ids
HGNC: 12652¹
Entrez Gene: 7408²
UniProtKB: P50552³
Ensembl: ENSG00000125753⁷

Search outside databases for aliases for VASP gene

Previous GC identifers: GC19P046654 GC19P046401 GC19P050686

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VASP:

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP

family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E

motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family

members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their

C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated

with filamentous actin formation and likely plays a widespread role in cell adhesion and motility.

VASP may also be involved in the intracellular signaling pathways that regulate

integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent

kinases PKA and PKG. [provided by RefSeq]

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes

dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and

filopodial dynamics in migrating cells. VASP promotes actin nucleation and increases the rate of

actin polymerization in the presence of capping protein. Plays a role in actin-based activity of

Listeria monocytogenes in platelets (By similarity)

Gene Wiki entry for VASP (Vasodilator-stimulated_phosphoprotein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VASP gene

Entrez Gene cytogenetic band: 19q13.2-q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2-q13.3

VASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P050702: (about GC identifiers)

Start:	50,702,528 bp from pter
End:	50,722,081 bp from pter
Size:	19,554 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 (See protein sequence)

Recommended Name: Vasodilator-stimulated phosphoprotein

Size: 380 amino acids; 39830 Da

Subunit: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1,

with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions

and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1

domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP.

Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP (By similarity)

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell

projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress

fibers and focal adhesions through interaction with a number of proteins including MRL family

members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips.

Stimulation by thrombin or PMA, also translocates VASP to focal adhesions

PDB structures from and Proteopedia :

1EGX (3D)

1JNG (3D)

1USD (3D)

1USE (3D)

2PAV (3D)

2PBD (3D)

3CHW (3D)

Secondary accessions: Q6PIZ1 Q93035

Post-translational modifications:

Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The

preferred site for PKA is Ser-157, the preferred site for PKG, Ser-239. In ADP-activated

platelets, phosphorylation by PKA or PKG on Ser-157 leads to fibrinogen receptor inhibition.

Phosphorylation on Thr-278 requires prior phosphorylation on Ser-157 and Ser-239. In response to

phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin,

phosphorylated by both PKC and ROCK1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003361.1

ENSEMBL proteins:

ENSP00000245932 ENSP00000384386 ENSP00000367017

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VASP)
	Human Recombinant Proteins from Abnova (VASP)

OriGene Purified Recombinant Human Protein: VASP

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IDA	18029348
GO:0015629	actin cytoskeleton	TAS	7828592
GO:0030054	cell junction	IEA	--

About this table

Antibodies for VASP:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of VASP
	Sigma-Aldrich Antibodies for VASP
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for VASP
	Antibodies from Abcam (VASP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VASP)
	Novus Biologicals Antibodies for VASP

Assays for VASP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50552

ProtoNet protein and cluster: P50552

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for

G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for

actin polymerization. Block B is required for F-actin binding and subcellular location, and Block

C for tetramerization

Domain: The WH1 domain mediates interaction with XIRP1

Similarity: Belongs to the Ena/VASP family

Similarity: Contains 1 WH1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VASP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003370

Applied Biosystems Silencer® siRNAs for VASP

Sigma-Aldrich siRNA for VASP

Sigma-Aldrich shRNA Panels and shRNA for VASP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VASP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003370
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003370
untagged cDNA clones in CMV expression vector (see all 2): NM_001008736

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003370

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes

dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and

filopodial dynamics in migrating cells. VASP promotes actin nucleation and increases the rate of

actin polymerization in the presence of capping protein. Plays a role in actin-based activity of

Listeria monocytogenes in platelets (By similarity)

Genatlas biochemistry entry for VASP:

vasodilator-stimulated phosphoprotein,expressed in platelets and a wide variety of other

cells,associated with actin filaments and focal adhesions which form the interface between

cytoskeleton and extracellular matrix,involved in cGMP and cAMP mediated inhibition of

agonist-induced platelet aggregation

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vasp):

	hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
nervous system	other

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for VASP (Your Favorite Gene powered by Ingenuity)

Fc&gamma
Axonal Guidance Signaling
Tight Junction Signaling
Leukocyte Extravasation Signaling
Integrin Signaling

GeneDecks VASP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VASP

5/66 Interacting proteins for VASP (P50552² ENSP00000245932³) via UniProtKB, MINT, and/or STRING (see all 66 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709², ENSP00000349960³	MINT-5115772 STRING (score=.906)
NSMAF	Q92636²	MINT-5115772 MINT-5115793
DMRTB1	Q96MA1²	MINT-66826
NOL3	O60936²	MINT-67223
PLSCR1	O15162²	MINT-67637

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VASP
10/13 Novoseek chemical compound relationships for VASP gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prasugrel	78.51	4	18217157 (3), 19025429 (1)
cgmp	70.25	72	12576312 (6), 10710123 (4), 1315268 (3), 18079117 (3) (see all 25)
adp	54.17	23	18832777 (3), 18022387 (2), 10446085 (2), 17482663 (2) (see all 10)
guanylate	43.92	1	10710123 (1)
forskolin	42.23	4	15381390 (1), 14602552 (1), 16973907 (1), 7925440 (1)
nitric oxide	39.42	38	17049286 (4), 18559661 (4), 15670578 (3), 18445594 (2) (see all 16)
proline	21.96	4	12529859 (1), 7737110 (1), 14983521 (1)
tyrosine	13.58	6	9693373 (1), 18983522 (1), 12087107 (1), 16176981 (1) (see all 6)
cyclic amp	11.59	2	1659381 (1)
threonine	8.32	3	8182057 (2), 11919161 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VASP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003370

Sigma-Aldrich siRNA for VASP

Sigma-Aldrich shRNA Panels and shRNA for VASP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003370

REFSEQ mRNAs for VASP gene:

NM_003370.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003370

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003370
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003370
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001008736

Additional cDNA sequence:

AK314812.1 BC026019.1 BC038224.1 CR615417.1 Z46389.1

18 DOTS entries:

DT.99938233 DT.87017206 DT.100795570 DT.97859810 DT.95258746 DT.100038079 DT.121499781 DT.40305661

DT.75107009 DT.91758247 DT.97859811 DT.100766382 DT.100795577 DT.40118443 DT.95148695 DT.97812970

DT.91691180 DT.95258763

24/341 AceView cDNA sequences (see all 341 ):

AI540053 BM832076 BQ057786 BM795110 BQ963024 AA748592 AA805727 AL560214

BQ889895 AW002482 AL041942 AI690419 BQ709677 BC026019 AV652596 Z46389

BG745679 BF515553 BC038224 BQ061490 BM893785 BE276838 CR615417 BU855671

highest scoring ESTs for VASP:

Z46389 AA034948 AA053271 AA053652 AA128272 AA128569 AA215773 AA251483 AA305874 AA327351

Unigene Cluster for VASP:

Vasodilator-stimulated phosphoprotein

Hs.515469 [show with all ESTs]

Unigene Representative Sequence: NM_003370

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VASP (see all 9 )

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b
SP1:																																	-				-
SP2:															-		-		-		-												-				-
SP3:																																	-				-
SP4:																																	-
SP5:			-		-

About this scheme

ECgene alternative splicing isoforms for VASP

3 Ensembl transcripts including schematic representations:

ENST00000245932 ENST00000407001 ENST00000377786

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VASP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VASP

¹ / ² / ³

3 probe-sets matching VASP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39105_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Z46389	1.00	1.00	1.00	1
202205_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003370	0.60	1.00	0.82	1
202205_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VASP for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGCCCGGA

SOURCE GeneReport for Unigene cluster: Hs.515469
Expression variation in blood from EXPOLDB for VASP
UniProtKB/Swiss-Prot: VASP_HUMAN, P50552
Tissue specificity: Highly expressed in platelets

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VASP gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VASP¹	--	vasodilator-stimulated phosphoprotein	88.3(n) 90.5(a)	403936 NM_001003256.1 NP_001003256.1
chimpanzee (Pan troglodytes)	VASP¹	--	vasodilator-stimulated phosphoprotein	98.95(n) 98.68(a)	468919 XM_001165347.1 XP_001165347.1
cow (Bos taurus)	VASP¹	--	vasodilator-stimulated phosphoprotein	86.93(n) 87.63(a)	514902 NM_001038110.1 NP_001033199.1
rat (Rattus norvegicus)	Vasp¹	--	vasodilator-stimulated phosphoprotein	86.1(n) 87.97(a)	361517 XM_341799.3 XP_341800.2
mouse (Mus musculus)	Vasp^{1, 5}	7⁵	vasodilator-stimulated phosphoprotein^{1, 5}	87.32(n)¹ 88.56(a)¹	22323¹ NM_009499.1¹ NP_033525.1¹ AA107290⁵ AF084548⁵ (see all 18)

About this table Species with no ortholog for VASP

ENSEMBL Gene Tree for VASP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VASP gene

ENAH² EVL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/116 NCBI SNPs in VASP are shown (see all 116 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10995^1,2	A,C,F,H,O	50721994(+)	`AAGGAA/GAAGGG`	1	--	ut3¹ trp³		6	MN EU EA WA	790
	rs2238688^1,2	C,F,H	50701360(+)	`AGGATG/CACGTG`	1	--	ng5¹		11	EA EU WA NA	1762
	rs10415373^1,2	C,F,H	50713159(+)	`TTGCCG/ACCGGC`	1	T/A	mis¹ ese³		8	EU EA WA	838
	rs34345197^1,2	C,F	50716496(+)	`GAGCAG/TCAGAA`	1	Q/H	mis¹		5	NA EU EA WA	498
	rs1051898^1,2	A,H	50721705(+)	`TTTTTC/TTCTTT`	1	--	ut3¹ trp³		5	MN EU EA WA	602
--	rs17426324^1,2	F	50701821(+)	`CTGTCC/TTCCGC`	1	--	ng5¹		2	MN EA	376
--	rs2301283^1,2	C,F,H	50716424(+)	`GGAGGT/GGGGCC`	1	G/G	syn¹		4	EU EA WA	412
	rs8099878^1,2	A,C,F,H	50711441(+)	`GGCGAG/TGGGTG`	1	--	int¹		11	EU EA WA NA	982
	rs758761^1,2	A,C,F,H	50704855(+)	`GCCAGG/AATTCA`	1	--	int¹		9	MN EU EA WA	1006
--	rs2239378^1,2	A,C,F,H	50713354(+)	`GTGACC/TGTGTG`	1	--	int¹		4	EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for VASP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601703

7 Novoseek disease relationships for VASP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	55.66	1	12023040 (1)
shigellosis	28.62	1	10021367 (1)
inflammation	3.73	2	16480498 (2)
cancer	0.00	1	18357390 (1)
breast cancer	0.00	2	18813837 (6), 19171136 (1)
metastasis	0.00	1	18813837 (1)
cardiovascular diseases	0.00	1	15634270 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

Tailored Clopidogrel Treatment Reduces Risk of Stent Thrombosis: Presented at AHA

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/180 PubMed articles for VASP gene (see all 180 ):

Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. (PubMed id 8812448)^{1, 2, 3, 4} Zimmer M....Walter U. (1996)
Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. (PubMed id 7828592)^{1, 3, 4} Haffner C....Walter U. (1995)
The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. (PubMed id 7737110)^{1, 3, 4} Reinhard M.... Walter U. (1995)
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. (PubMed id 8182057)^{1, 3, 4} Butt E.... Walter U. (1994)
Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. (PubMed id 16197368)^{1, 3, 4} Wentworth J.K.... Poole A.W. (2006)
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (PubMed id 15939738)^{1, 3, 4} Barzik M.... Schafer D.A. (2005)
Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. (PubMed id 7925440)^{1, 3, 4} Horstrup K....Walter U. (1994)
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (PubMed id 15569942)^{1, 3, 4} Kuehnel K.... Strelkov S.V. (2004)
The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. (PubMed id 10438535)^{1, 3, 4} Bachmann C.... Reinhard M. (1999)
Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. (PubMed id 10990454)^{1, 3, 4} Ball L.J.... Jarchau T. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7408	HGNC: 12652	AceView: VASP	Ensembl:ENSG00000125753	euGenes: HUgn7408
ECgene: VASP	H-InvDB: VASP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for VASP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VASP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VASP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VASP		Antibodies for VASP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VASP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VASP)
	Antibodies (VASP)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for VASP

	Recombinant Proteins (VASP)
	Antibodies (VASP)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for VASP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VASP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VASP Gene at Home site.
Version 2.41.1
server4.xennexinc.com

VASP Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VASP

Summaries
for VASP

Genomic Location
for VASP

Proteins
for VASP

Protein Domains/
Families
for VASP

Gene Function
for VASP

Pathways & Interactions
for VASP

Drugs & Compounds
for VASP

Transcripts
for VASP

Expression
for VASP

Orthologs
for VASP

Paralogs
for VASP

SNPs/Variants
for VASP

Disorders & Mutations
for VASP

Medical News
for VASP

Publications
for VASP

Search for VASP

Genome Databases showing VASP

Other Databases showing VASP

Specialized Databases showing VASP

Licensable Technologies
for VASP

Services
for VASP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VASP Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VASP

Summariesfor VASP

Genomic Locationfor VASP

Proteinsfor VASP

Protein Domains/Familiesfor VASP

Gene Functionfor VASP

Pathways & Interactionsfor VASP

Drugs & Compoundsfor VASP

Transcriptsfor VASP

Expression for VASP

Orthologsfor VASP

Paralogsfor VASP

SNPs/Variantsfor VASP

Disorders & Mutationsfor VASP

Medical Newsfor VASP

Publicationsfor VASP

Search for VASP

Genome Databases showing VASP

Other Databases showing VASP

Specialized Databases showing VASP

Licensable Technologiesfor VASP

Servicesfor VASP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VASP

Summaries
for VASP

Genomic Location
for VASP

Proteins
for VASP

Protein Domains/
Families
for VASP

Gene Function
for VASP

Pathways & Interactions
for VASP

Drugs & Compounds
for VASP

Transcripts
for VASP

Expression
for VASP

Orthologs
for VASP

Paralogs
for VASP

SNPs/Variants
for VASP

Disorders & Mutations
for VASP

Medical News
for VASP

Publications
for VASP

Licensable Technologies
for VASP

Services
for VASP