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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VASP Gene

protein-coding GIFtS: 64
GCID: GC19P046010

vasodilator-stimulated phosphoprotein

Explore 20 diseases affiliated with
VASP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vasodilator-Stimulated Phosphoprotein¹ ²

External Ids:	HGNC: 12652¹	Entrez Gene: 7408²	Ensembl: ENSG00000125753⁷	OMIM: 601703⁵	UniProtKB: P50552³

Export aliases for VASP gene to outside databases

Previous GC identifers: GC19P046654 GC19P046401 GC19P050686 GC19P050702 GC19P042440

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VASP:

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members

contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to

focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW

domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP

is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP

may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions.

VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton

remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and

cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against

capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin

filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin

filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in

platelets and plays an important role in regulating platelet aggregation

Gene Wiki entry for VASP (Vasodilator-stimulated phosphoprotein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VASP gene promoter:
CREB NRSF form 1 deltaCREB NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VASP promoter sequence

Search SABiosciences Chromatin IP Primers for VASP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VASP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

VASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VASP gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046010: view genomic region (about GC identifiers)

Start:	46,009,837 bp from pter	End:	46,030,241 bp from pter
Size:	20,405 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552 (See protein sequence)

Recommended Name: Vasodilator-stimulated phosphoprotein

Size: 380 amino acids; 39830 Da

Subunit: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the

Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of

actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of

Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3

domain of DNMBP (By similarity)

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, lamellipodium

membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction

with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia

and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the

sides of actin filaments throughout the peripheral cytoplasm under basal conditions

Miscellaneous: VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet

reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients at risk for these problems

6/7 PDB 3D structures from and Proteopedia for VASP (see all 7):

1EGX (3D)

1JNG (3D)

1USD (3D)

1USE (3D)

2PAV (3D)

2PBD (3D)

Secondary accessions: B2RBT9 Q6PIZ1 Q93035

Explore the universe of human proteins at neXtProt for VASP: NX_P50552

Post-translational modifications:

Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for

PKA is Ser-157, the preferred site for PKG/PRKG1, Ser-239. In ADP-activated platelets, phosphorylation by PKA or PKG

on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior phosphorylation on

Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to

thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-278 by AMPK does not require prior

phosphorylation at Ser-157 or Ser-239. Phosphorylation modulates F-actin binding, actin filament elongation and

platelet activation. Phosphorylation at Ser-322 by AMPK also alters actin filament binding. Carbon monoxide (CO)

promotes phosphorylation at Ser-157, while nitric oxide (NO) promotes phosphorylation at Ser-157, but also at Ser-239.

Response to NO and CO is blunted in platelets from diabetic patients, and VASP is not phosphorylated efficiently at

Ser-157 and Ser-239¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50552

VASP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003361.1

ENSEMBL proteins:

ENSP00000467061 ENSP00000245932 ENSP00000464742 ENSP00000467773 ENSP00000467005

ENSP00000466319

Reactome Protein details: P50552
Human Recombinant Protein Products:

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	Uscn Proteins for VASP

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IDA	--
GO:0005925	focal adhesion	IDA	--
GO:0015629	actin cytoskeleton	TAS	7828592

VASP for ontologies About GeneDecksing

VASP Antibody Products:

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	ThermoFisher Antibodies for VASP

Assay Products for VASP:

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	GenScript Custom Assay Services for VASP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VASP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VASP for domains About GeneDecksing

4 InterPro domains/families:

IPR017354 Vasodilator_phosphoprotein

IPR014885 VASP_tetra

IPR011993 PH_like_dom

IPR000697 EVH1

Graphical View of Domain Structure for InterPro Entry P50552

ProtoNet protein and cluster: P50552

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The

KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required

for F-actin binding and subcellular location, and Block C for tetramerization

Domain: The WH1 domain mediates interaction with XIRP1

Similarity: Belongs to the Ena/VASP family

Similarity: Contains 1 WH1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton

remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and

cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against

capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin

filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin

filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in

platelets and plays an important role in regulating platelet aggregation

Genatlas biochemistry entry for VASP:

vasodilator-stimulated phosphoprotein,expressed in platelets and a wide variety of other cells,associated with actin

filaments and focal adhesions which form the interface between cytoskeleton and extracellular matrix,involved in cGMP

and cAMP mediated inhibition of agonist-induced platelet aggregation

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		hsa-miR-3910 hsa-miR-4291 hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-548a-3p hsa-miR-1323 hsa-miR-93

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASP

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005522	profilin binding	IPI	17914456
GO:0017124	SH3 domain binding	IEA	--

VASP for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for VASP: Vasp^tm1Mzim Vasp^tm1Ref
     6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vasp):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	mortality/aging
nervous system

VASP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	Activation of PKA through GPCR	0.71

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Cell-cell junction organization

Cell junction organization

0.69

Cell-Cell communication

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for VASP

Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VASP

	Activation of PKA through GPCR
	PKA Signaling
	Epithelial Tight Junctions
	Activation of cAMP-Dependent PKA
	Actin Nucleation by ARP-WASP Complex

1 Cell Signaling Technology (CST) Pathway for VASP

Cytoskeletal Signaling

1 GeneGo (Thomson Reuters) Pathway for VASP

Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

4 BioSystems Pathways for VASP

	Integrin-mediated cell adhesion
	Focal Adhesion
	E-cadherin signaling in keratinocytes
	Stabilization and expansion of the E-cadherin adherens junction

5/10 Reactome Pathways for VASP (see all 10)

	Cell-extracellular matrix interactions
	Developmental Biology
	Signaling by Robo receptor
	Adaptive Immune System
	Cell junction organization

3 Kegg Pathways (Kegg details for VASP):

	Focal adhesion
	Fc gamma R-mediated phagocytosis
	Leukocyte transendothelial migration

VASP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VASP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/690 Interacting proteins for VASP (P50552^{1, 2, 3} ENSP00000245932⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 690)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NSMAF	Q92636²^,³, ENSP00000411012⁴	MINT-5115772 MINT-5115793 I2D: score=1 STRING: ENSP00000411012
NOL3	O60936²^,³, ENSP00000268605⁴	MINT-67223 I2D: score=5 STRING: ENSP00000268605
TRIM9	Q9C026²^,³, ENSP00000298355⁴	MINT-67679 I2D: score=4 STRING: ENSP00000298355
XPO6	Q96QU8²^,³, ENSP00000302790⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000302790
SPTA1	P02549²^,³, ENSP00000357130⁴	MINT-7211723 I2D: score=2 STRING: ENSP00000357130

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0008154	actin polymerization or depolymerization	IEA	--
GO:0030036	actin cytoskeleton organization	--	--
GO:0034329	cell junction assembly	TAS	--

VASP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

VASP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VASP

1 HMDB Compound for VASP About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/25 Novoseek chemical compound relationships for VASP gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
clopidogrel	82	56	18217157 (5), 15634270 (4), 18387444 (4), 15583724 (3) (see all 24)
prasugrel	81.7	5	18217157 (3), 19025429 (1), 19435740 (1)
cgmp	69.9	76	12576312 (6), 10710123 (4), 1315268 (3), 18079117 (3) (see all 26)
pge1	56.1	23	18832777 (4), 1713458 (2), 2154470 (2), 1315268 (1) (see all 8)
adp	55.8	29	18832777 (3), 18022387 (2), 17482663 (2), 10446085 (2) (see all 13)
kt 5823	54	5	10922374 (3), 12576312 (1)
sodium nitroprusside	46.5	14	2154470 (2), 1315268 (1), 7980622 (1), 16360131 (1) (see all 8)
aspirin	46.2	5	19135705 (2), 17635731 (1), 19652892 (1)
forskolin	42.9	5	15381390 (1), 14602552 (1), 16973907 (1), 7925440 (1) (see all 5)
kt 5720	42	2	12576312 (1), 11313394 (1)

Search CenterWatch for drugs/clinical trials and news about VASP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VASP gene (2 alternative transcripts):

NM_003370.3 NM_001008736.1

Unigene Cluster for VASP:

Vasodilator-stimulated phosphoprotein

Hs.515469 [show with all ESTs]

Unigene Representative Sequence: NM_003370

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000589627 ENST00000245932(uc002pcg.3 uc002pci.3) ENST00000592139

ENST00000590603 ENST00000586014 ENST00000586619 ENST00000588482 ENST00000590459

ENST00000588463 ENST00000588273 ENST00000587444

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Additional cDNA sequence:

AK314812.1 BC026019.1 BC038224.1 Z46389.1

18 DOTS entries:

DT.99938233 DT.87017206 DT.100795570 DT.97859810 DT.95258746 DT.100038079 DT.121499781 DT.40305661

DT.75107009 DT.91758247 DT.100766382 DT.100795577 DT.40118443 DT.95148695 DT.97812970 DT.97859811

DT.91691180 DT.95258763

24/341 AceView cDNA sequences (see all 341):

AL544323 AI690419 BQ709677 BF515553 AA865383 BI833611 AI493947 BM893946

AL550805 BQ057786 BI770480 BM909517 BM795110 Z46389 AL041942 BE276838

BQ710298 BF516111 AA514402 AA805727 AW002482 BQ889895 BM893785 NM_003370

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VASP (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b
SP1:																																	-				-
SP2:															-		-		-		-												-				-
SP3:																																	-				-
SP4:																																	-
SP5:			-		-

ECgene alternative splicing isoforms for VASP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VASP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCCGGA

About this image

VASP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Outflow Tract

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VASP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VASP

SOURCE GeneReport for Unigene cluster: Hs.515469

UniProtKB/Swiss-Prot: VASP_HUMAN, P50552

Tissue specificity: Highly expressed in platelets

SABiosciences Expression via Pathway-Focused PCR Arrays including VASP:

Cytoskeleton Regulators in human mouse rat

Focal Adhesions in human mouse rat

Cell Motility in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for VASP gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vasp^{1 , 5}	vasodilator-stimulated phosphoprotein^{1, 5}	87.38(n)¹ 88.8(a)¹		7 (9.51 cM)⁵ 22323¹ NM_009499.2¹ NP_033525.2¹ 19256929⁵
lizard (Anolis carolinensis)	Reptilia	VASP⁶	--	79(a)	1 ↔ 1	AAWZ02038402(2382-6769)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23446²	Xenopus laevis transcribed sequence with weak similarity more	75.35(n)		BU915668.1
zebrafish (Danio rerio)	Actinopterygii	vasp⁶ zgc:162320⁶	zgc:162320	52(a) 41(a)	many → 1 many → 1	18(39059004-39153445) 10(1939-19705)
fruit fly (Drosophila melanogaster)	Insecta	ena³	axon guidance actin binding	43(a)		--
barley (Hordeum vulgare)	Liliopsida	BF267187.2²	--	77.85(n)		BF267187.2

ENSEMBL Gene Tree for VASP (if available)
TreeFam Gene Tree for VASP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for VASP gene

ENAH² EVL²

1 SIMAP similar gene for VASP using alignment to 6 protein entries: VASP_HUMAN (see all proteins):

EVL

VASP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182692664^1,2		--	46008777(+)	`AGGATA/CGAATG`	1	--	us2k¹		0	--	--	--	--
rs76298062^1,2	C,F,	--	46008803(+)	`ACTGCG/ACTCCG`	1	--	us2k¹		1		WA	118
rs188208183^1,2		--	46008907(+)	`CCACCC/TCTCCT`	1	--	us2k¹		0	--	--	--	--
rs3216350^1,2	C,	--	46009239(+)	`GCTACT/-TTAGG`	1	--	us2k¹		1		NA	2
rs140604523^1,2		--	46009330(+)	`GGTGAC/TAGCGA`	1	--	us2k¹		0	--	--	--	--
rs60720534^1,2	C	--	46009349(+)	`AAAAA-/AGAAAA`	1	--	us2k¹		0	--	--	--	--
rs2238688^1,2	C,F,H,	--	46009520(+)	`AGGATG/CACGTG`	1	--	us2k¹		18		EA NS NA CSA WA	2128
rs28487950^1,2	C,F,H,	--	46009613(+)	`CTCACA/GTAGTC`	1	--	us2k¹		7		NS NA	890
rs147933333^1,2	C,	--	46009634(+)	`GAGAA-/TTGTTGGT`	1	--	us2k¹		0	--	--	--	--
rs192791481^1,2		--	46009661(+)	`TTGGTA/GGCTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VASP (46009837 - 46030241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VASP: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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VASP for disorders           About GeneDecksing

OMIM gene information: 601703    OMIM disorders: --

20 diseases for VASP:    About MalaCards

wiskott-aldrich syndrome myocardial infarction acute myocardial infarction autoimmune myocarditis

shigellosis myocarditis crohn's disease vaccinia

breast cancer thrombosis gastric cancer blindness

lung cancer prostate cancer sarcoma cerebritis

cholesterol hypoxia prostatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for VASP:

Coronary heart disease

8 Novoseek disease relationships for VASP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	53.5	1	12023040 (1)
shigellosis	26.3	1	10021367 (1)
tumors	3.47	1	20307526 (1)
cardiovascular diseases	0	1	15634270 (1)
inflammation	0	2	16480498 (2)
breast cancer	0	2	18813837 (6), 19171136 (1)
metastasis	0	1	18813837 (1)
cancer	0	1	18357390 (1)

Export disorders for VASP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for VASP gene, integrated from 9 sources (see all 245):
(articles sorted by number of sources associating them with VASP)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. (PubMed id 8812448)^{1, 2, 3, 9} Zimmer M....Walter U. (1996)
Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. (PubMed id 7828592)^{1, 2, 9} Haffner C....Walter U. (1995)
The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. (PubMed id 7737110)^{1, 2, 9} Reinhard M.... Walter U. (1995)
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. (PubMed id 8182057)^{1, 2, 9} Butt E.... Walter U. (1994)
Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. (PubMed id 16197368)^{1, 2, 9} Wentworth J.K.... Poole A.W. (2006)
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (PubMed id 15939738)^{1, 2, 9} Barzik M.... Schafer D.A. (2005)
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. (PubMed id 18559661)^{1, 2, 9} Li Calzi S.... Grant M.B. (2008)
Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. (PubMed id 7925440)^{1, 2, 9} Horstrup K....Walter U. (1994)
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. (PubMed id 15569942)^{1, 2, 9} Kuehnel K.... Strelkov S.V. (2004)
The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. (PubMed id 10438535)^{1, 2, 9} Bachmann C.... Reinhard M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7408	HGNC: 12652	AceView: VASP	Ensembl:ENSG00000125753	euGenes: HUgn7408
ECgene: VASP	Kegg: 7408	H-InvDB: VASP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for VASP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VASP gene
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Patent Information for VASP gene:
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GeneCards and IP:
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vasodilator-stimulated phosphoprotein

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vasodilator-stimulated phosphoprotein

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