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Aliases for VASN Gene

Aliases for VASN Gene

  • Vasorin 2 3 5
  • Protein Slit-Like 2 3 4
  • SLITL2 3 4
  • Slit-Like 2 (Drosophila) 2
  • Slit-Like 2 3

External Ids for VASN Gene

Previous HGNC Symbols for VASN Gene

  • SLITL2

Previous GeneCards Identifiers for VASN Gene

  • GC16P004364

Summaries for VASN Gene

GeneCards Summary for VASN Gene

VASN (Vasorin) is a Protein Coding gene. GO annotations related to this gene include transforming growth factor beta binding.

UniProtKB/Swiss-Prot for VASN Gene

  • May act as an inhibitor of TGF-beta signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASN Gene

Genomics for VASN Gene

Regulatory Elements for VASN Gene

Enhancers for VASN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VASN on UCSC Golden Path with GeneCards custom track

Promoters for VASN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VASN on UCSC Golden Path with GeneCards custom track

Genomic Location for VASN Gene

Chromosome:
16
Start:
4,371,848 bp from pter
End:
4,383,528 bp from pter
Size:
11,681 bases
Orientation:
Plus strand

Genomic View for VASN Gene

Genes around VASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASN Gene

Proteins for VASN Gene

  • Protein details for VASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EMK4-VASN_HUMAN
    Recommended name:
    Vasorin
    Protein Accession:
    Q6EMK4
    Secondary Accessions:
    • Q6UXL4
    • Q6UXL5
    • Q96CX1

    Protein attributes for VASN Gene

    Size:
    673 amino acids
    Molecular mass:
    71713 Da
    Quaternary structure:
    • Interacts with TGFB1, TGFB2 and TGFB3.

neXtProt entry for VASN Gene

Proteomics data for VASN Gene at MOPED

Post-translational modifications for VASN Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn 101, Asn 117, Asn 273, Thr 319, Ser 487, Asn 500, Ser 516, Asn 528, and Thr 567
  • Modification sites at PhosphoSitePlus

Other Protein References for VASN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for VASN (Vasorin/SLIT-like 2)

No data available for DME Specific Peptides for VASN Gene

Domains & Families for VASN Gene

Suggested Antigen Peptide Sequences for VASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EMK4

UniProtKB/Swiss-Prot:

VASN_HUMAN :
  • Contains 1 EGF-like domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with VASN: view

No data available for Gene Families for VASN Gene

Function for VASN Gene

Molecular function for VASN Gene

UniProtKB/Swiss-Prot Function:
May act as an inhibitor of TGF-beta signaling.
genes like me logo Genes that share phenotypes with VASN: view

Animal Models for VASN Gene

MGI Knock Outs for VASN:

Animal Model Products

  • Taconic Biosciences Mouse Models for VASN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASN Gene

Localization for VASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASN Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASN Gene COMPARTMENTS Subcellular localization image for VASN gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 4
mitochondrion 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VASN: view

Pathways & Interactions for VASN Gene

SuperPathways for VASN Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VASN Gene

Drugs & Compounds for VASN Gene

No Compound Related Data Available

Transcripts for VASN Gene

mRNA/cDNA for VASN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VASN Gene

Vasorin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VASN Gene

No ASD Table

Relevant External Links for VASN Gene

GeneLoc Exon Structure for
VASN
ECgene alternative splicing isoforms for
VASN

Expression for VASN Gene

mRNA expression in normal human tissues for VASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASN Gene

This gene is overexpressed in Urine (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VASN Gene



SOURCE GeneReport for Unigene cluster for VASN Gene Hs.372579

mRNA Expression by UniProt/SwissProt for VASN Gene

Q6EMK4-VASN_HUMAN
Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.
genes like me logo Genes that share expression patterns with VASN: view

Protein tissue co-expression partners for VASN Gene

Primer Products

No data available for mRNA differential expression in normal tissues for VASN Gene

Orthologs for VASN Gene

This gene was present in the common ancestor of animals.

Orthologs for VASN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VASN 35
  • 86.21 (n)
  • 85.69 (a)
VASN 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VASN 35
  • 86.16 (n)
  • 87.05 (a)
VASN 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vasn 35
  • 80.62 (n)
  • 83.9 (a)
Vasn 16
Vasn 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VASN 35
  • 99.55 (n)
  • 99.55 (a)
VASN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vasn 35
  • 82.06 (n)
  • 84.2 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia VASN 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASN 35
  • 63.22 (n)
  • 56.81 (a)
VASN 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vasn 35
  • 53.77 (n)
  • 50.58 (a)
zebrafish
(Danio rerio)
Actinopterygii vasna 35
  • 50.99 (n)
  • 45.12 (a)
vasna 36
  • 39 (a)
OneToMany
vasnb 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-14 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for VASN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VASN Gene

ENSEMBL:
Gene Tree for VASN (if available)
TreeFam:
Gene Tree for VASN (if available)

Paralogs for VASN Gene

(1) SIMAP similar genes for VASN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VASN: view

No data available for Paralogs for VASN Gene

Variants for VASN Gene

Sequence variations from dbSNP and Humsavar for VASN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_025991 -

Structural Variations from Database of Genomic Variants (DGV) for VASN Gene

Variant ID Type Subtype PubMed ID
nsv527866 CNV Loss 19592680
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
dgv2585n71 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
nsv471075 CNV Loss 18288195
esv23732 CNV Gain 19812545
nsv905232 CNV Loss 21882294
nsv905233 CNV Loss 21882294
nsv520212 CNV Loss 19592680
nsv833132 CNV Loss 17160897

Variation tolerance for VASN Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VASN Gene

Disorders for VASN Gene

Relevant External Links for VASN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASN

No disorders were found for VASN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASN Gene

Publications for VASN Gene

  1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PMID: 15247411) Ikeda Y. … Kitamura T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for VASN Gene

Sources for VASN Gene

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