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Aliases for VASN Gene

Aliases for VASN Gene

  • Vasorin 2 3 3 5
  • Protein Slit-Like 2 3 4
  • SLITL2 3 4
  • Slit-Like 2 (Drosophila) 2
  • Slit-Like 2 3

External Ids for VASN Gene

Previous HGNC Symbols for VASN Gene

  • SLITL2

Previous GeneCards Identifiers for VASN Gene

  • GC16P004364

Summaries for VASN Gene

GeneCards Summary for VASN Gene

VASN (Vasorin) is a Protein Coding gene. GO annotations related to this gene include transforming growth factor beta binding.

UniProtKB/Swiss-Prot for VASN Gene

  • May act as an inhibitor of TGF-beta signaling.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASN Gene

Genomics for VASN Gene

Regulatory Elements for VASN Gene

Enhancers for VASN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G004297 1.5 Ensembl ENCODE dbSUPER 11.8 -72.9 -72894 3.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 FOS DEK ZHX2 CREBBP ZNF500 PAM16 VASN LINC01569 GC16P004295 GC16M004304
GH16G004458 1.5 Ensembl ENCODE dbSUPER 11.1 +87.5 87457 1.7 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF121 SP5 MIER2 NMRAL1 VASN PAM16 MGRN1 CORO7 GC16P004458 GC16M004469
GH16G004293 1.4 Ensembl ENCODE dbSUPER 11.8 -77.7 -77664 1.8 CREB3L1 AGO1 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF263 REST TSHZ1 PAM16 VASN LINC01569 GC16P004295 GC16P004288
GH16G004391 1.3 Ensembl ENCODE dbSUPER 11.9 +21.8 21796 4.2 KLF1 NFIB TEAD4 SIN3A RBBP5 ZIC2 RAD21 YY1 ETS1 ZFHX2 NMRAL1 HMOX2 VASN PAM16 MGRN1 CORO7-PAM16
GH16G004295 1 dbSUPER 11.8 -76.3 -76288 0.8 FOXA2 CREB3L1 MLX ARID4B DMAP1 ZNF48 ZNF2 YY1 SLC30A9 SP5 PAM16 VASN LINC01569 GC16P004295 GC16P004288
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VASN on UCSC Golden Path with GeneCards custom track

Promoters for VASN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082793 452 1001 AGO1 ARID4B SIN3A ZNF48 YY1 ZNF143 SP3 MXD4 NFYC GLIS1

Genomic Location for VASN Gene

Chromosome:
16
Start:
4,371,848 bp from pter
End:
4,383,528 bp from pter
Size:
11,681 bases
Orientation:
Plus strand

Genomic View for VASN Gene

Genes around VASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASN Gene

Proteins for VASN Gene

  • Protein details for VASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EMK4-VASN_HUMAN
    Recommended name:
    Vasorin
    Protein Accession:
    Q6EMK4
    Secondary Accessions:
    • Q6UXL4
    • Q6UXL5
    • Q96CX1

    Protein attributes for VASN Gene

    Size:
    673 amino acids
    Molecular mass:
    71713 Da
    Quaternary structure:
    • Interacts with TGFB1, TGFB2 and TGFB3.

neXtProt entry for VASN Gene

Post-translational modifications for VASN Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn101, Asn117, isoforms=273, Thr319, Ser487, Asn500, isoforms=516, isoforms=528, and Thr567
  • Modification sites at PhosphoSitePlus

Other Protein References for VASN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for VASN (Vasorin/SLIT-like 2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for VASN

No data available for DME Specific Peptides for VASN Gene

Domains & Families for VASN Gene

Suggested Antigen Peptide Sequences for VASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VASN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for VASN Gene

Function for VASN Gene

Molecular function for VASN Gene

UniProtKB/Swiss-Prot Function:
May act as an inhibitor of TGF-beta signaling.

Gene Ontology (GO) - Molecular Function for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding IDA 25468996
GO:0050431 transforming growth factor beta binding IPI 15247411
genes like me logo Genes that share ontologies with VASN: view
genes like me logo Genes that share phenotypes with VASN: view

Animal Models for VASN Gene

MGI Knock Outs for VASN:

Animal Model Products

  • Taconic Biosciences Mouse Models for VASN

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VASN
  • R&D Systems cDNA Clones for VASN (Vasorin/SLIT-like 2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASN Gene

Localization for VASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASN Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASN gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
mitochondrion 2
peroxisome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15247411
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IEA,IBA --
genes like me logo Genes that share ontologies with VASN: view

Pathways & Interactions for VASN Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 21170088
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 21170088
GO:0071456 cellular response to hypoxia IEA --
GO:0071461 cellular response to redox state IEA --
genes like me logo Genes that share ontologies with VASN: view

No data available for Pathways by source and SIGNOR curated interactions for VASN Gene

Drugs & Compounds for VASN Gene

No Compound Related Data Available

Transcripts for VASN Gene

mRNA/cDNA for VASN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VASN Gene

Vasorin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VASN
  • R&D Systems cDNA Clones for VASN (Vasorin/SLIT-like 2)

Alternative Splicing Database (ASD) splice patterns (SP) for VASN Gene

No ASD Table

Relevant External Links for VASN Gene

GeneLoc Exon Structure for
VASN
ECgene alternative splicing isoforms for
VASN

Expression for VASN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASN Gene

This gene is overexpressed in Urine (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VASN Gene



Protein tissue co-expression partners for VASN Gene

NURSA nuclear receptor signaling pathways regulating expression of VASN Gene:

VASN

SOURCE GeneReport for Unigene cluster for VASN Gene:

Hs.372579

mRNA Expression by UniProt/SwissProt for VASN Gene:

Q6EMK4-VASN_HUMAN
Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.

Evidence on tissue expression from TISSUES for VASN Gene

  • Liver(4.2)
  • Lung(4.2)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with VASN: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VASN Gene

Orthologs for VASN Gene

This gene was present in the common ancestor of animals.

Orthologs for VASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASN 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia VASN 34 35
  • 86.21 (n)
dog
(Canis familiaris)
Mammalia VASN 34 35
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Vasn 34
  • 82.06 (n)
mouse
(Mus musculus)
Mammalia Vasn 34 16 35
  • 80.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VASN 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASN 34 35
  • 63.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia vasn 34
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii vasna 34 35
  • 50.99 (n)
vasnb 35
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-14 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
Species where no ortholog for VASN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VASN Gene

ENSEMBL:
Gene Tree for VASN (if available)
TreeFam:
Gene Tree for VASN (if available)

Paralogs for VASN Gene

(1) SIMAP similar genes for VASN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VASN: view

No data available for Paralogs for VASN Gene

Variants for VASN Gene

Sequence variations from dbSNP and Humsavar for VASN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000120584 -- 4,380,768(+) GCATT(C/T)GGGGG intron-variant
rs1000293207 -- 4,383,129(+) ATGAG(G/T)ACAGT intron-variant, utr-variant-3-prime
rs1000535008 -- 4,372,891(+) CCAAG(C/G)ACAGG intron-variant
rs1000604888 -- 4,371,838(+) TGCCT(A/C)CAGCG intron-variant, upstream-variant-2KB
rs1000948203 -- 4,372,681(+) GCAGT(A/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VASN Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv3584924 CNV gain 24956385
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for VASN Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASN Gene

Disorders for VASN Gene

Relevant External Links for VASN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASN

No disorders were found for VASN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASN Gene

Publications for VASN Gene

  1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PMID: 15247411) Ikeda Y. … Kitamura T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 22 64
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells. (PMID: 26157350) Huang A. … Shao N. (Int. J. Biol. Sci. 2015) 3 64

Products for VASN Gene

Sources for VASN Gene

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