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Aliases &
Descriptions
for VASN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| OTTHUMP00000159843 2 | | SLITL2 2, 3 | | vasorin 2 |
| | | Descriptions |
|---|
| Protein slit-like 2 3 | | slit-like 2 2 | | slit-like 2 (Drosophila) 1 |
|
| |
Search outside databases for aliases for VASN gene |
Summaries
for VASN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4Function: May act as an inhibitor of TGF-beta signaling |
Genomic Location
for VASN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the VASN gene 
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3VASN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P004364:
(about GC identifiers)
Start:
|
4,361,850 bp from pter |
End:
|
4,373,530 bp from pter |
Size:
|
11,681 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_037887.4
| Proteins
for VASN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4 (See
protein sequence)Recommended Name: Vasorin precursor Size: 673 amino acids; 71713 Da
Subunit: Interacts with TGFB1, TGFB2 and TGFB3
Subcellular location: Membrane; Single-pass type I membrane protein (Probable). Secreted
Secondary accessions: Q6UXL4 Q6UXL5 Q96CX1Post-translational modifications:
N-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_612449.2
ENSEMBL proteins: ENSP00000306864
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VASN:
Assays for VASN: | Protein
Domains/
Families
for VASN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6EMK4
ProtoNet protein and cluster: Q6EMK4 4 Blocks protein families: IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature IPB006210 Type I EGF
UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4Similarity: Contains 1 EGF-like domainSimilarity: Contains 1 fibronectin type-III domainSimilarity: Contains 11 LRR (leucine-rich) repeats | Gene Function
for VASN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC013767
 Applied Biosystems Silencer® siRNAs for VASN
 Sigma-Aldrich siRNA and siRNA Panels for VASN
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_138440
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138440
untagged cDNA clones in CMV expression vector (see all 2): BC013767
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_138440
UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4Function: May act as an inhibitor of TGF-beta signaling1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- |
About this table | Pathways & Interactions
for VASN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for VASN (ENSP000003068643) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for VASN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for VASN
|
Transcripts
for VASN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC013767
Sigma-Aldrich siRNA and siRNA Panels for VASN
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_138440 REFSEQ mRNAs for VASN gene: NM_138440.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138440
OriGene GFP tagged cDNA clone in CMV expression vector: NM_138440
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138440
untagged cDNA clones in CMV expression vector (see all 2): BC013767
Additional cDNA sequence: AY166584.1 AY358298.1 AY358299.1 BC013767.1 BC068575.1 CR625381.1 7 DOTS entries: DT.101962694 DT.111971 DT.95086701 DT.97845089 DT.120686752 DT.100035553 DT.95086698 24/178 AceView cDNA sequences (see all 178
):BQ003821 BQ940782 CR625381 AI955870 AA902669 CD676790 BU527131 BM681638 BU623918 BE742185 AI561259 AW072844 AI825128 BM681227 BC068575 BM712754 AY358298 AW273147 AW337946 AW193322 AI818468 CA432277 BM676098 AI207341
 highest scoring ESTs for VASN:AI971709 AA250733 AA327876 AA385255 AA448630 AA448721 AA455784 AA456607 AA977038 AI052433 Unigene Cluster for VASN: Vasorin Hs.372579 [show with all ESTs]Unigene Representative Sequence: NM_138440
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000304735
|
Expression
for VASN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VASN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VASN
1 / 2 / 3 3 probe-sets matching VASN gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTTGCTTTT
SOURCE GeneReport for Unigene cluster: Hs.372579
UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and
placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta,
the strongest expression is found in the tunica media of the proximal ascending aorta, the
descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney,
expression is found in the interstitial cells |
Orthologs
for VASN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VASN gene from 5 species
About this table Species with no ortholog for VASN
ENSEMBL Gene Tree for VASN | Paralogs
for VASN(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for VASN gene
- FLRT12 FLRT22 FLRT32
|
SNPs/Variants
for VASN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for VASN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608843
|
Medical News
for VASN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for VASN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for VASN gene:- Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PubMed id 15247411)1, 2, 3, 4 Ikeda Y.... Kitamura T. (2004)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)4 Chen R.... Zou H. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Slit-like 2, a novel zebrafish slit homologue that might involve in zebrafish central neural and vascular morphogenesis. (PubMed id 16125671)1 Chen L....Xue J.L. (2005)
- Papaverine PVC membrane ion-selective electrodes based on its ion-exchangers with tetraphenylborate and tetrathiocyanate anions. (PubMed id 17899889)1 Abbas M.N. and Mostafa G.A. (2007)
|
Search for VASN
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VASN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VASN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VASN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for VASN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for VASN:
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