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Aliases for VASN Gene

Aliases for VASN Gene

  • Vasorin 2 3 3 5
  • Protein Slit-Like 2 3 4
  • SLITL2 3 4
  • Slit-Like 2 (Drosophila) 2
  • Slit-Like 2 3

External Ids for VASN Gene

Previous HGNC Symbols for VASN Gene

  • SLITL2

Previous GeneCards Identifiers for VASN Gene

  • GC16P004364

Summaries for VASN Gene

GeneCards Summary for VASN Gene

VASN (Vasorin) is a Protein Coding gene. GO annotations related to this gene include transforming growth factor beta binding.

UniProtKB/Swiss-Prot for VASN Gene

  • May act as an inhibitor of TGF-beta signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASN Gene

Genomics for VASN Gene

Regulatory Elements for VASN Gene

Enhancers for VASN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004460 0.9 ENCODE 24.3 +89.8 89802 1.5 MLX ARID4B ZNF2 ZNF48 SP5 REST KAT8 SREBF1 MBD2 SSRP1 VASN NMRAL1 PAM16 GC16P004458 GC16M004469
GH16F004368 1 FANTOM5 ENCODE 14 +2.5 2461 11.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF500 CREBBP NMRAL1 ZNF597 ENSG00000261789 LOC105371066 LOC105371067 VASN ENSG00000261442 ZNF174
GH16F004407 1 FANTOM5 Ensembl ENCODE 13.5 +40.7 40689 10.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 NMRAL1 VASN CORO7 HMOX2 MGRN1 NUDT16L1 CORO7-PAM16
GH16F004424 0.2 ENCODE 13.5 +54.2 54246 3.3 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ZNF500 NMRAL1 CREBBP ZNF597 ENSG00000261789 LOC105371067 LOC105371066 VASN CLUAP1 HMOX2
GH16F004270 1.1 FANTOM5 ENCODE 13.4 -99.1 -99134 4.5 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 CLUAP1 ENSG00000261789 LOC105371066 LOC105371067 VASN TIGD7 ENSG00000261442 LINC01569 MTCO1P28 CDIP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VASN on UCSC Golden Path with GeneCards custom track

Promoters for VASN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502917 1152 2801 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 FOS SP3 SP5 NFYC

Genomic Location for VASN Gene

Chromosome:
16
Start:
4,371,848 bp from pter
End:
4,383,528 bp from pter
Size:
11,681 bases
Orientation:
Plus strand

Genomic View for VASN Gene

Genes around VASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASN Gene

Proteins for VASN Gene

  • Protein details for VASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EMK4-VASN_HUMAN
    Recommended name:
    Vasorin
    Protein Accession:
    Q6EMK4
    Secondary Accessions:
    • Q6UXL4
    • Q6UXL5
    • Q96CX1

    Protein attributes for VASN Gene

    Size:
    673 amino acids
    Molecular mass:
    71713 Da
    Quaternary structure:
    • Interacts with TGFB1, TGFB2 and TGFB3.

neXtProt entry for VASN Gene

Post-translational modifications for VASN Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn 101, Asn 117, Asn 273, Thr 319, Ser 487, Asn 500, Ser 516, Asn 528, and Thr 567
  • Modification sites at PhosphoSitePlus

Other Protein References for VASN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for VASN (Vasorin/SLIT-like 2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for VASN

No data available for DME Specific Peptides for VASN Gene

Domains & Families for VASN Gene

Suggested Antigen Peptide Sequences for VASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EMK4

UniProtKB/Swiss-Prot:

VASN_HUMAN :
  • Contains 1 EGF-like domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with VASN: view

No data available for Gene Families for VASN Gene

Function for VASN Gene

Molecular function for VASN Gene

UniProtKB/Swiss-Prot Function:
May act as an inhibitor of TGF-beta signaling.

Gene Ontology (GO) - Molecular Function for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0050431 transforming growth factor beta binding IPI 15247411
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with VASN: view
genes like me logo Genes that share phenotypes with VASN: view

Animal Models for VASN Gene

MGI Knock Outs for VASN:

Animal Model Products

  • Taconic Biosciences Mouse Models for VASN

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASN Gene

Localization for VASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASN Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASN Gene COMPARTMENTS Subcellular localization image for VASN gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 4
mitochondrion 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15247411
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IEA,IBA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with VASN: view

Pathways & Interactions for VASN Gene

SuperPathways for VASN Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 21170088
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 21170088
GO:0071456 cellular response to hypoxia IEA --
GO:0071461 cellular response to redox state IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with VASN: view

No data available for Pathways by source and SIGNOR curated interactions for VASN Gene

Transcripts for VASN Gene

mRNA/cDNA for VASN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VASN Gene

Vasorin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASN Gene

No ASD Table

Relevant External Links for VASN Gene

GeneLoc Exon Structure for
VASN
ECgene alternative splicing isoforms for
VASN

Expression for VASN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASN Gene

This gene is overexpressed in Urine (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VASN Gene



Protein tissue co-expression partners for VASN Gene

NURSA nuclear receptor signaling pathways regulating expression of VASN Gene:

VASN

SOURCE GeneReport for Unigene cluster for VASN Gene:

Hs.372579

mRNA Expression by UniProt/SwissProt for VASN Gene:

Q6EMK4-VASN_HUMAN
Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.
genes like me logo Genes that share expression patterns with VASN: view

Primer Products

No data available for mRNA differential expression in normal tissues for VASN Gene

Orthologs for VASN Gene

This gene was present in the common ancestor of animals.

Orthologs for VASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASN 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia VASN 34 35
  • 86.21 (n)
dog
(Canis familiaris)
Mammalia VASN 34 35
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Vasn 34
  • 82.06 (n)
mouse
(Mus musculus)
Mammalia Vasn 34 16 35
  • 80.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VASN 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASN 34 35
  • 63.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia vasn 34
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii vasna 34 35
  • 50.99 (n)
vasnb 35
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-14 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
Species where no ortholog for VASN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VASN Gene

ENSEMBL:
Gene Tree for VASN (if available)
TreeFam:
Gene Tree for VASN (if available)

Paralogs for VASN Gene

(1) SIMAP similar genes for VASN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VASN: view

No data available for Paralogs for VASN Gene

Variants for VASN Gene

Sequence variations from dbSNP and Humsavar for VASN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10445037 -- 4,374,253(+) CCTTC(C/T)TTTTA intron-variant
rs11076826 -- 4,377,009(+) ACCAA(C/G)TCACC intron-variant
rs111548603 -- 4,382,341(+) AGCTC(C/T)GTGCA intron-variant, reference, synonymous-codon
rs111555804 -- 4,381,081(+) CTCGA(C/T)GCAGG intron-variant, reference, synonymous-codon
rs111618257 -- 4,383,626(+) CTGGG(C/T)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VASN Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv3584924 CNV gain 24956385
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for VASN Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASN Gene

Disorders for VASN Gene

Relevant External Links for VASN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASN

No disorders were found for VASN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASN Gene

Publications for VASN Gene

  1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PMID: 15247411) Ikeda Y. … Kitamura T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 22 64
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells. (PMID: 26157350) Huang A. … Shao N. (Int. J. Biol. Sci. 2015) 3 64

Products for VASN Gene

Sources for VASN Gene

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