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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VASN Gene

protein-coding   GIFtS: 48
GCID: GC16P004421

vasorin

(Previous name: slit-like 2 (Drosophila) )
(Previous symbol: SLITL2)
 Explore 2 diseases affiliated with
VASN via our new
 Human Malady Compendium 
Biological research products
for VASN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Vasorin1
SLITL21 2 3
Protein Slit-Like 22 3
Slit-Like 2 (Drosophila)1
Slit-Like 22

External Ids:    HGNC: 185171   Entrez Gene: 1149902   Ensembl: ENSG000001681407   OMIM: 6088435   UniProtKB: Q6EMK43   

Export aliases for VASN gene to outside databases

Previous GC identifer: GC16P004364


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
Function: May act as an inhibitor of TGF-beta signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VASN gene promoter:
         NF-1/L   NF-1   MIF-1   Tal-1beta   E47   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVASN promoter sequence
   Search SABiosciences Chromatin IP Primers for VASN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VASN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

VASN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VASN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004421:  view genomic region     (about GC identifiers)

Start:
4,421,849 bp from pter      End:
4,433,529 bp from pter
Size:
11,681 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4 (See protein sequence)
Recommended Name: Vasorin precursor  
Size: 673 amino acids; 71713 Da
Subunit: Interacts with TGFB1, TGFB2 and TGFB3
Subcellular location: Membrane; Single-pass type I membrane protein (Probable). Secreted
Secondary accessions: Q6UXL4 Q6UXL5 Q96CX1

Explore the universe of human proteins at neXtProt for VASN: NX_Q6EMK4

Post-translational modifications:

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor)
  • and dHex1Hex6HexNAc5 (minor)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6EMK4

  • VASN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612449.2  
    ENSEMBL proteins: 
     ENSP00000306864  

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    Uscn Proteins for VASN

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral to membrane IEA--


    VASN for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VASN for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR000742 EG-like_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q6EMK4

    ProtoNet protein and cluster: Q6EMK4

    4 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
    Function: May act as an inhibitor of TGF-beta signaling

    miRNA
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    hsa-miR-520d-5p hsa-miR-146a hsa-miR-3921 hsa-miR-550a* hsa-miR-3142 hsa-miR-4326 hsa-miR-761 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidVASN 3' UTR sequence
    Inhib. RNA
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    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vasn):
     cellular  homeostasis/metabolism  liver/biliary system  mortality/aging  no phenotypic analysis 
     reproductive system 

    VASN for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VASN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for VASN (Q6EMK43 ENSP000003068644) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1P011373, ENSP000002219304I2D: score=2 STRING: ENSP00000221930
    TGFB2P618123, ENSP000003558964I2D: score=2 STRING: ENSP00000355896
    TGFB3P106003, ENSP000002386824I2D: score=2 STRING: ENSP00000238682
    NCSTNENSP000002947854STRING: ENSP00000294785
    PSEN1ENSP000003263664STRING: ENSP00000326366
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VASN
    Search CenterWatch for drugs/clinical trials and news about VASN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VASN gene: 
    NM_138440.2  

    Unigene Cluster for VASN:

    Vasorin
    Hs.372579  [show with all ESTs]
    Unigene Representative Sequence: NM_138440
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304735(uc002cwj.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VASN
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VASN (see all 18):
    hsa-miR-520d-5p hsa-miR-146a hsa-miR-3921 hsa-miR-550a* hsa-miR-3142 hsa-miR-4326 hsa-miR-761 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidVASN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VASN (see all 7)
    OriGene shRNA RFP: VASN
    OriGene siRNA: VASN
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VASN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VASN

    Additional cDNA sequence: 

    AY166584.1 AY358298.1 AY358299.1 BC013767.1 BC068575.1 

    7 DOTS entries:

    DT.101962694  DT.111971  DT.95086701  DT.97845089  DT.100035553  DT.120686752  DT.95086698 

    24/178 AceView cDNA sequences (see all 178):

    BU527131 AI207341 AA902669 BM091378 BC013767 CO246839 BC068575 CF529597 
    AI952164 CA420527 CA432277 AW513859 BU625887 BG108940 CD676790 AW337946 
    CR625381 CO248921 AY166584 AW273147 AI825128 AI561259 AW072844 CA448218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VASN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGCTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    VASN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VASN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VASN

    SOURCE GeneReport for Unigene cluster: Hs.372579

    UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
    Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest
    levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the
    tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary
    arteries. Within the kidney, expression is found in the interstitial cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VASN gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves VASN6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    14(13401962-13403854)
    zebrafish
    (Danio rerio)
    Actinopterygii vasna1 vasorin a 50.34(n)
    44.48(a)
      553185  NM_001018131.1  NP_001018141.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta conv6
    chp6
    (see all 5)
    chaoptic
    (see all 5)
    6(a)
    5(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    2R(10158306-10162377)
    3R(27029902-27036452)


    ENSEMBL Gene Tree for VASN (if available)
    TreeFam Gene Tree for VASN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VASN gene
    GP52  FLRT12  CPN22  LRIG32  LRRTM42  CHAD2  FLRT32  LRRC152  
    LRIG22  LRRTM32  IGFALS2  CHADL2  LRIG12  LRRTM22  FLRT22  LRRTM12  
    1 SIMAP similar gene for VASN using alignment to 1 protein entry:     VASN_HUMAN:
    LRIG3

    VASN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for VASN
         1 CNV: 72438
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VASN
    DNA2.0 Custom Variant and Variant Library Synthesis for VASN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VASN for disorders           About GeneDecksing

    OMIM gene information: 608843    OMIM disorders: --

    2 diseases for VASN:    About MalaCards
    aspiration pneumonia    pneumonia


    Export disorders for VASN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VASN gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with VASN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PubMed id 15247411)1, 2, 3, 9 Ikeda Y.... Kitamura T. (2004)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114990 HGNC: 18517 AceView: LOC114990 Ensembl:ENSG00000168140 euGenes: HUgn114990
    ECgene: VASN H-InvDB: VASN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VASN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VASN gene:
    Search GeneIP for patents involving VASN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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