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Aliases for VASN Gene

Aliases for VASN Gene

  • Vasorin 2 3
  • Protein Slit-Like 2 3 4
  • SLITL2 3 4
  • Slit-Like 2 (Drosophila) 2
  • Slit-Like 2 3

External Ids for VASN Gene

Previous HGNC Symbols for VASN Gene

  • SLITL2

Previous GeneCards Identifiers for VASN Gene

  • GC16P004364

Summaries for VASN Gene

GeneCards Summary for VASN Gene

VASN (Vasorin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VASN Gene

  • May act as an inhibitor of TGF-beta signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASN Gene

Genomics for VASN Gene

Regulatory Elements for VASN Gene

Genomic Location for VASN Gene

Start:
4,371,848 bp from pter
End:
4,383,528 bp from pter
Size:
11,681 bases
Orientation:
Plus strand

Genomic View for VASN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASN Gene

Proteins for VASN Gene

  • Protein details for VASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EMK4-VASN_HUMAN
    Recommended name:
    Vasorin
    Protein Accession:
    Q6EMK4
    Secondary Accessions:
    • Q6UXL4
    • Q6UXL5
    • Q96CX1

    Protein attributes for VASN Gene

    Size:
    673 amino acids
    Molecular mass:
    71713 Da
    Quaternary structure:
    • Interacts with TGFB1, TGFB2 and TGFB3.

neXtProt entry for VASN Gene

Proteomics data for VASN Gene at MOPED

Post-translational modifications for VASN Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn101, Asn117, Asn273, Thr319, Ser487, Asn500, Ser516, Asn528, and Thr567
  • Modification sites at PhosphoSitePlus

Other Protein References for VASN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VASN Gene

Domains for VASN Gene

Suggested Antigen Peptide Sequences for VASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EMK4

UniProtKB/Swiss-Prot:

VASN_HUMAN :
  • Q6EMK4
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with VASN: view

No data available for Gene Families for VASN Gene

Function for VASN Gene

Molecular function for VASN Gene

UniProtKB/Swiss-Prot Function: May act as an inhibitor of TGF-beta signaling.

Gene Ontology (GO) - Molecular Function for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0050431 transforming growth factor beta binding IPI 15247411
genes like me logo Genes that share ontologies with VASN: view
genes like me logo Genes that share phenotypes with VASN: view

Animal Model Products

CRISPR Products

miRNA for VASN Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VASN Gene

Localization for VASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASN Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASN Gene COMPARTMENTS Subcellular localization image for VASN gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15247411
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 15247411
genes like me logo Genes that share ontologies with VASN: view

Pathways for VASN Gene

SuperPathways for VASN Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 21170088
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 21170088
GO:0071456 cellular response to hypoxia IEA --
GO:0071461 cellular response to redox state IEA --
genes like me logo Genes that share ontologies with VASN: view

No data available for Pathways by source for VASN Gene

Transcripts for VASN Gene

mRNA/cDNA for VASN Gene

(178) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VASN Gene

Vasorin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VASN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VASN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASN Gene

No ASD Table

Relevant External Links for VASN Gene

GeneLoc Exon Structure for
VASN
ECgene alternative splicing isoforms for
VASN

Expression for VASN Gene

mRNA expression in normal human tissues for VASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VASN Gene

SOURCE GeneReport for Unigene cluster for VASN Gene Hs.372579

mRNA Expression by UniProt/SwissProt for VASN Gene

Q6EMK4-VASN_HUMAN
Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.
genes like me logo Genes that share expressions with VASN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VASN Gene

Orthologs for VASN Gene

This gene was present in the common ancestor of animals.

Orthologs for VASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASN 35
  • 99.55 (n)
  • 99.55 (a)
VASN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VASN 35
  • 86.21 (n)
  • 85.69 (a)
VASN 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VASN 35
  • 86.16 (n)
  • 87.05 (a)
VASN 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vasn 35
  • 80.62 (n)
  • 83.9 (a)
Vasn 16
Vasn 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VASN 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vasn 35
  • 82.06 (n)
  • 84.2 (a)
chicken
(Gallus gallus)
Aves VASN 35
  • 63.22 (n)
  • 56.81 (a)
VASN 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vasn 35
  • 53.77 (n)
  • 50.58 (a)
zebrafish
(Danio rerio)
Actinopterygii vasna 35
  • 50.99 (n)
  • 45.12 (a)
vasna 36
  • 39 (a)
OneToMany
vasnb 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-14 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for VASN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VASN Gene

ENSEMBL:
Gene Tree for VASN (if available)
TreeFam:
Gene Tree for VASN (if available)

Paralogs for VASN Gene

Selected SIMAP similar genes for VASN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VASN: view

No data available for Paralogs for VASN Gene

Variants for VASN Gene

Sequence variations from dbSNP and Humsavar for VASN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_025991 -

Structural Variations from Database of Genomic Variants (DGV) for VASN Gene

Variant ID Type Subtype PubMed ID
nsv527866 CNV Loss 19592680
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
dgv2585n71 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
nsv471075 CNV Loss 18288195
esv23732 CNV Gain 19812545
nsv905232 CNV Loss 21882294
nsv905233 CNV Loss 21882294
nsv520212 CNV Loss 19592680
nsv833132 CNV Loss 17160897

Relevant External Links for VASN Gene

HapMap Linkage Disequilibrium report
VASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASN Gene

Disorders for VASN Gene

No disorders were found for VASN Gene.

No data available for UniProtKB/Swiss-Prot for VASN Gene

Publications for VASN Gene

  1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PMID: 15247411) Ikeda Y. … Kitamura T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3

Products for VASN Gene

Sources for VASN Gene

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