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VASN Gene

protein-coding   GIFtS: 50
GCID: GC16P004421

Vasorin

(Previous name: slit-like 2 (Drosophila))
(Previous symbol: SLITL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
vasorin1 2
SLITL21 2 3
Protein Slit-Like 22 3
Slit-Like 2 (Drosophila)1
Slit-Like 22

External Ids:    HGNC: 185171   Entrez Gene: 1149902   Ensembl: ENSG000001681407   OMIM: 6088435   UniProtKB: Q6EMK43   

Export aliases for VASN gene to outside databases

Previous GC identifer: GC16P004364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VASN Gene:
VASN (vasorin) is a protein-coding gene.

UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
Function: May act as an inhibitor of TGF-beta signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  NT_187608.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the VASN gene promoter:
         NF-1/L   NF-1   MIF-1   Tal-1beta   E47   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVASN promoter sequence
   Search Chromatin IP Primers for VASN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VASN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

VASN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VASN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004421:  view genomic region     (about GC identifiers)

Start:
4,421,849 bp from pter      End:
4,433,529 bp from pter
Size:
11,681 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4 (See protein sequence)
Recommended Name: Vasorin precursor  
Size: 673 amino acids; 71713 Da
Subunit: Interacts with TGFB1, TGFB2 and TGFB3
Secondary accessions: Q6UXL4 Q6UXL5 Q96CX1

Explore the universe of human proteins at neXtProt for VASN: NX_Q6EMK4

Explore proteomics data for VASN at MOPED

Post-translational modifications: 

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5
    (minor) and dHex1Hex6HexNAc5 (minor)1
  • Glycosylation2 at Asn101, Asn117, Asn273, Thr319, Ser487, Asn500, Ser516, Asn528, Thr567
  • Modification sites at PhosphoSitePlus

  • See VASN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612449.2  
    ENSEMBL proteins: 
     ENSP00000306864  

    VASN Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for VASN
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    antibodies-online proteins for VASN (8 products) 

     
    antibodies-online peptides for VASN

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    antibodies-online antibodies for VASN (19 products) 

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    Cloud-Clone Corp. ELISAs for VASN
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    antibodies-online kits for VASN (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000742 EG-like_dom
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6EMK4

    ProtoNet protein and cluster: Q6EMK4

    4 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with VASN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VASN_HUMAN, Q6EMK4
    Function: May act as an inhibitor of TGF-beta signaling

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with VASN           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vasn):
     cellular  homeostasis/metabolism  liver/biliary system  mortality/aging  no phenotypic analysis 
     reproductive system 

    Find genes that share phenotypes with VASN           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VASN

    miRNA
    Products:
        
    miRTarBase miRNAs that target VASN:
    hsa-mir-124-3p (MIRT022816), hsa-mir-335-5p (MIRT018355), hsa-mir-375 (MIRT019949), hsa-mir-16-5p (MIRT031814)

    Block miRNA regulation of human, mouse, rat VASN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VASN (see all 18):
    hsa-miR-520d-5p hsa-miR-146a hsa-miR-3921 hsa-miR-550a* hsa-miR-3142 hsa-miR-4326 hsa-miR-761 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidVASN 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for VASN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VASN

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VASN_HUMAN, Q6EMK4: Membrane; Single-pass type I membrane protein (Probable). Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005739mitochondrion IEA--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with VASN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VASN
    Interactions:

        Search GeneGlobe Interaction Network for VASN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for VASN (Q6EMK43 ENSP000003068644) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1P011373, ENSP000002219304I2D: score=2 STRING: ENSP00000221930
    TGFB2P618123, ENSP000003558964I2D: score=2 STRING: ENSP00000355896
    TGFB3P106003, ENSP000002386824I2D: score=2 STRING: ENSP00000238682
    NCSTNENSP000002947854STRING: ENSP00000294785
    PSEN1ENSP000003263664STRING: ENSP00000326366
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071456cellular response to hypoxia IEA--
    GO:0071461cellular response to redox state IEA--

    Find genes that share ontologies with VASN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VASN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VASN gene: 
    NM_138440.2  

    Unigene Cluster for VASN:

    Vasorin
    Hs.372579  [show with all ESTs]
    Unigene Representative Sequence: NM_138440
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304735(uc002cwj.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VASN (see all 18):
    hsa-miR-520d-5p hsa-miR-146a hsa-miR-3921 hsa-miR-550a* hsa-miR-3142 hsa-miR-4326 hsa-miR-761 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidVASN 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat VASN
      QuantiFast Probe-based Assays in human, mouse, rat VASN

    Additional mRNA sequence: 

    AY166584.1 AY358298.1 AY358299.1 BC013767.1 BC068575.1 

    7 DOTS entries:

    DT.101962694  DT.111971  DT.95086701  DT.97845089  DT.100035553  DT.120686752  DT.95086698 

    Selected AceView cDNA sequences (see all 178):

    AA448630 BQ013629 BQ448719 BQ003821 AI682120 AI983635 BU623918 AW273147 
    AI955870 CF529597 BM681227 BM676098 C02034 AI818468 CA391294 BM710746 
    AW193322 BM712754 CA396797 CA432038 BQ012798 CO246839 BC013767 BQ940782 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VASN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGCTTTT
    VASN Expression
    About this image


    VASN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    VASN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VASN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372579

    UniProtKB/Swiss-Prot: VASN_HUMAN, Q6EMK4
    Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at
    lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is
    found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and
    the coronary arteries. Within the kidney, expression is found in the interstitial cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VASN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vasn1 , 5 vasorin1, 5 80.62(n)1
    83.9(a)1
      16 (2.46 cM)5
    2461541  NM_139307.31  NP_647468.21 
     46399415 
    chicken
    (Gallus gallus)
    Aves VASN1 vasorin 63.22(n)
    56.81(a)
      101749629  XM_004945391.1  XP_004945448.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vasn1 vasorin 53.77(n)
    50.58(a)
      448556  NM_001005036.1  NP_001005036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vasna1 vasorin a 50.99(n)
    45.12(a)
      553185  NM_001018131.1  NP_001018141.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lron-146
    Protein LRON-14, isoform a (lron-14) mRNA, complet...
    15(a)
    1 ↔ 1
    IV(9560787-9566605) WBGene00011454


    ENSEMBL Gene Tree for VASN (if available)
    TreeFam Gene Tree for VASN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VASN gene
    1 SIMAP similar gene for VASN using alignment to 1 protein entry:     VASN_HUMAN:
    LRIG3

    Find genes that share paralogs with VASN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for VASN    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38108181,2,4
    ----see VAR_0259912 mis40--------

    HapMap Linkage Disequilibrium report for VASN (4421849 - 4433529 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VASN (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471075CNV Loss18288195
    nsv833132CNV Loss17160897
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905233CNV Loss21882294
    nsv905223CNV Loss21882294
    dgv2586n71CNV Loss21882294
    dgv2585n71CNV Loss21882294
    nsv905232CNV Loss21882294
    nsv520212CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VASN
    DNA2.0 Custom Variant and Variant Library Synthesis for VASN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608843    OMIM disorders: --


    Find genes that share disorders with VASN           About GenesLikeMe


    Export disorders for VASN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VASN gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with VASN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PubMed id 15247411)1, 2, 3, 9 Ikeda Y.... Kitamura T. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    7. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (Mol. Cell. Proteomics 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114990 HGNC: 18517 AceView: LOC114990 Ensembl:ENSG00000168140 euGenes: HUgn114990
    ECgene: VASN H-InvDB: VASN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VASN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VASN gene:
    Search GeneIP for patents involving VASN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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