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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VASH2 Gene

protein-coding   GIFtS: 43
GCID: GC01P213123

Vasohibin 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vasohibin 21 2
Vasohibin-Like Protein2 3
RP11-275G3.12
vasohibin-22
VASHL3

External Ids:    HGNC: 257231   Entrez Gene: 798052   Ensembl: ENSG000001434947   OMIM: 6104715   UniProtKB: Q86V253   

Export aliases for VASH2 gene to outside databases

Previous GC identifers: GC01P211190 GC01P183798


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VASH2 Gene: 
VASH2 (vasohibin 2) is a protein-coding gene. Diseases associated with VASH2 include endotheliitis. An important paralog of this gene is VASH1.

UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25
Function: Angiogenesis inhibitor. Inhibits network formation by endothelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VASH2 gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVASH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for VASH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VASH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q23

VASH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VASH2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P213123:  view genomic region     (about GC identifiers)

Start:
213,123,862 bp from pter      End:
213,165,379 bp from pter
Size:
41,518 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 (See protein sequence)
Recommended Name: Vasohibin-2  
Size: 355 amino acids; 40450 Da
Developmental stage: Expressed in various embryonic organs at 6 to 12 embryonic weeks. Detected in vessels from
20-week embryonic organs as well as in endothelial cells from large vessels in neonate
Sequence caution: Sequence=CAH71916.1; Type=Erroneous initiation; Sequence=CAH71918.1; Type=Erroneous initiation;
Secondary accessions: Q2VT46 Q5VTE7 Q5VTE9 Q7Z6E3 Q8IZ24 Q9H9W5
Alternative splicing: 5 isoforms:  Q86V25-1   Q86V25-2   Q86V25-3   Q86V25-4   Q86V25-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VASH2: NX_Q86V25

Explore proteomics data for VASH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86V25

  • VASH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VASH2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129946.1  NP_001129947.1  NP_079025.2  

    ENSEMBL proteins: 
     ENSP00000430319   ENSP00000355935   ENSP00000419918   ENSP00000355932   ENSP00000429040  
     ENSP00000428324   ENSP00000355931  

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    Cloud-Clone Corp. Proteins for VASH2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19204325

    VASH2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86V25

    UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25
    Similarity: Belongs to the vasohibin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VASH2_HUMAN, Q86V25
    Function: Angiogenesis inhibitor. Inhibits network formation by endothelial cells
    Induction: By VEGF

    Phenotypes:
         2 GenomeRNAi human phenotypes for VASH2:

     Decreased viability with pacli  Elongated cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Vash2):
     cardiovascular system 

    VASH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vash2tm1Ysat for VASH2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VASH2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VASH2

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    SwitchGear 3'UTR luciferase reporter plasmidVASH2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VASH2

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19204325
    GO:0045766positive regulation of angiogenesis IDA19204325

    VASH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VASH2

    Search CenterWatch for drugs/clinical trials and news about VASH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VASH2 gene (3 alternative transcripts): 
    NM_001136474.1  NM_001136475.1  NM_024749.3  

    Unigene Cluster for VASH2:

    Vasohibin 2
    Hs.96885  [show with all ESTs]
    Unigene Representative Sequence: NM_024749
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366966 ENST00000366968(uc001hjx.3 uc010ptn.2 uc001hjw.3 uc001hjy.3)
    ENST00000490792 ENST00000366965 ENST00000271776(uc001hjv.2) ENST00000366967
    ENST00000493155 ENST00000517399 ENST00000481097 ENST00000366969 ENST00000519906
    ENST00000366964(uc001hju.2)
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    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate VASH2 (see all 96):
    hsa-miR-3678-3p hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-200a hsa-miR-138-2* hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidVASH2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK022567.1 AK096605.1 AK290973.1 AK302675.1 AY834202.1 BC051856.1 

    8 DOTS entries:

    DT.100018664  DT.91661796  DT.121412716  DT.100710908  DT.100754549  DT.121412694  DT.95260350  DT.91657694 

    24/55 AceView cDNA sequences (see all 55):

    BE350485 BC051856 AI126990 AU124123 AA626409 BC028194 AW959420 AI198593 
    AK022567 AI291607 AU121363 NM_024749 AW169104 AI192696 BI825145 AK096605 
    AI285984 BF002094 AA301175 CF593746 BP368754 AA347615 AA424230 CB990557 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:        -           -     -     -           -           -                             -           -         
    SP2:        -     -     -     -     -     -     -                 -                                             
    SP3:                                            -           -                                                   
    SP4:                    -     -     -                                                                           
    SP5:        -                                                                                                   


    ECgene alternative splicing isoforms for VASH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VASH2 expression in normal human tissues (normalized intensities)      VASH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTTTAAT
    VASH2 Expression
    About this image


    VASH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 13 entries
             hIPS1
             ESI-049   
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Endothelium (Cardiovascular System)
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Blood (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See VASH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VASH2

    SOURCE GeneReport for Unigene cluster: Hs.96885
        SABiosciences Custom PCR Arrays for VASH2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VASH2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vash21 , 5 vasohibin 21, 5 90.14(n)1
    96.78(a)1
      1 (96.28 cM)5
    2268411  NM_144879.21  NP_659128.21 
     1909476485 
    chicken
    (Gallus gallus)
    Aves VASH21 vasohibin 2 72.6(n)
    77.33(a)
      421364  XM_419424.3  XP_419424.3 
    lizard
    (Anolis carolinensis)
    Reptilia VASH26
    Uncharacterized protein
    68(a)
    1 ↔ 1
    1(238762713-238807845)
    zebrafish
    (Danio rerio)
    Actinopterygii vash21 vasohibin 2 64.58(n)
    64.11(a)
      562668  NM_001025523.1  NP_001020694.1 


    ENSEMBL Gene Tree for VASH2 (if available)
    TreeFam Gene Tree for VASH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VASH2 gene
    VASH12  
    1 SIMAP similar gene for VASH2 using alignment to 3 protein entries:     VASH2_HUMAN (see all proteins):
    VASH1

    VASH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/896 SNPs in VASH2 are shown (see all 896)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558049891,2
    C--183833497(+) TTTTT-/TTTTTT
    /TTTTTTT
    GTAGA
    6 -- int1 cds11NA 2
    rs574789511,2
    C,F--213121929(+) TTCTCG/ACAAGA 3 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1815879801,2
    --213121978(+) CTGATA/GATTAG 3 -- us2k10--------
    rs1467060321,2
    --213121982(+) TAATTA/GGTGAT 3 -- us2k10--------
    rs1168278461,2
    F--213122121(+) TGGATA/GCTGGT 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1152088991,2
    C,F--213122138(+) TCAGAT/CGCACA 3 -- us2k12Minor allele frequency- C:0.02NA EA 240
    rs1873872621,2
    --213122189(+) ACTCCA/GCTGAT 3 -- us2k10--------
    rs1390021041,2
    --213122211(+) CTGTGA/CAGACC 3 -- us2k10--------
    rs1498845811,2
    --213122234(+) ATTAGG/TTCTCA 3 -- us2k10--------
    rs594544011,2
    F--213122373(+) TTAAGT/CCTTTG 3 -- us2k12Minor allele frequency- C:0.04CSA WA 119

    HapMap Linkage Disequilibrium report for VASH2 (213123862 - 213165379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for VASH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv271601CNV Insertion20981092
    esv29349CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610471    OMIM disorders: --

    2 diseases for VASH2:    About MalaCards
    endotheliitis    


    VASH2 for disorders           About GeneDecksing


    Export disorders for VASH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VASH2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with VASH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of vasohibin-2 as a homologue of VEGF- inducible endothelium-derived angiogenesis inhibitor vasohibin. (PubMed id 16528006)1, 2, 3 Shibuya T....Sato Y. (2006)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genome-wide association studies identify several new l oci associated with pigmentation traits and skin cancer risk in European America ns. (PubMed id 23548203)1 Zhang M....Han J. (2013)
    6. Vasohibin 2 is transcriptionally activated and promote s angiogenesis in hepatocellular carcinoma. (PubMed id 22614011)1 Xue X....Kondo Y. (2013)
    7. The vasohibin family: a novel family for angiogenesis regulation. (PubMed id 23100270)1 Sato Y. (2013)
    8. Vasohibin-1 and vasohibin-2 expression in gastric canc er cells and TAMs. (PubMed id 22438034)1 Shen Z....Puolakkainen P. (2012)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79805 HGNC: 25723 AceView: FLJ12505 Ensembl:ENSG00000143494 euGenes: HUgn79805
    ECgene: VASH2 H-InvDB: VASH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VASH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VASH2 gene:
    Search GeneIP for patents involving VASH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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