VASH2 Gene
protein-coding GIFtS : 43
GCID: GC01 P213123
vasohibin 2
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Aliasesfor VASH2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Vasohibin 2 1 2 Vasohibin-Like Protein2 3 FLJ125051 RP11-275G3.12 Vasohibin-21 VASHL3
Export aliases for VASH2 gene to outside databases Previous GC identifers: GC01P211190 GC01P183798
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Summariesfor VASH2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 Function : Angiogenesis inhibitor. Inhibits network formation by endothelial cells
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Genomic Viewsfor VASH2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167186.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VASH2 gene promoter: AREB6 Other transcription factors Search SABiosciences Chromatin IP Primers for VASH2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VASH2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q23 VASH2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P213123: view genomic region
(about GC identifiers )
Start:
213,123,862 bp from pter
End:
213,165,379 bp from pter
Size:
41,518 bases
Orientation:
plus strand
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Proteinsfor VASH2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 (See
protein sequence )Recommended Name: Vasohibin-2 Size : 355 amino acids; 40450 Da
Developmental stage : Expressed in various embryonic organs at 6 to 12 embryonic weeks. Detected in vessels from 20-weekembryonic organs as well as in endothelial cells from large vessels in neonate
Sequence caution : Sequence=CAH71916.1; Type=Erroneous initiation; Sequence=CAH71918.1; Type=Erroneous initiation;
Secondary accessions : Q2VT46 Q5VTE7 Q5VTE9 Q7Z6E3 Q8IZ24 Q9H9W5Alternative splicing : 5 isoforms : Q86V25-1 Q86V25-2 Q86V25-3 Q86V25-4 Q86V25-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VASH2: NX_Q86V25 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86V25 VASH2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001129946.1 NP_001129947.1 NP_079025.2 ENSEMBL proteins: ENSP00000430319 ENSP00000355935 ENSP00000419918 ENSP00000355932 ENSP00000429040 ENSP00000428324 ENSP00000355931 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
VASH2 for ontologies About GeneDecksing VASH2 Antibody Products: Assay Products for VASH2:
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Protein
Domains / Familiesfor VASH2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q86V25
UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 Similarity : Belongs to the vasohibin family
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Functionfor VASH2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 Function : Angiogenesis inhibitor. Inhibits network formation by endothelial cellsInduction : By VEGF
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): VASH2 (NM_001136475 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VASH2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASH2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASH2
2 GenomeRNAi human phenotypes for VASH2 :Animal Models: Mouse knock-out Vash2 tm1Ysat for VASH2 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Vash2) :
VASH2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor VASH2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VASH2 Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
VASH2 for ontologies About GeneDecksing
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Drugs & Compoundsfor VASH2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for VASH2 Search CenterWatch for drugs/clinical trials and news about VASH2
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Transcriptsfor VASH2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for VASH2 gene (3 alternative transcripts): NM_001136474.1 NM_001136475.1 NM_024749.3 Unigene Cluster for VASH2:
Vasohibin 2 Hs.96885 [show with all ESTs ] Unigene Representative Sequence: NM_024749 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000366966 ENST00000366968 (uc001hjx.3 uc010ptn.2 uc001hjw.3 uc001hjy.3 )ENST00000490792 ENST00000366965 ENST00000271776 (uc001hjv.2 ) ENST00000366967 ENST00000493155 ENST00000517399 ENST00000481097 ENST00000366969 ENST00000519906 ENST00000366964 (uc001hju.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): VASH2 (NM_001136475 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VASH2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASH2
Additional cDNA sequence: AK022567.1 AK096605.1 AK290973.1 AK302675.1 AY834202.1 BC051856.1
8 DOTS entries : DT.100018664 DT.91661796
DT.121412716 DT.100710908 DT.100754549 DT.121412694 DT.95260350 DT.91657694 24/55 AceView cDNA sequences (see all 55 ):
AI126990 BE350485 AW959420 AU121363 AA626409 BC028194 AI198593 NM_024749 AK022567 AU124123 BC051856 AI291607 AI961235 AK096605 BX098851 BP368754 AA885478 BQ223577 CB990557 AI192696 AI400615 AA025824 AW169104 BC053836 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 SP1 :   -     -   -   -     -     -           -     -     SP2 :   -   -   -   -   -   -   -       -                 SP3 :               -     -                   SP4 :       -   -   -                           SP5 :   -                                  
ECgene alternative splicing isoforms for VASH2
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Expression for VASH2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section VASH2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGACTTTAAT
About this image VASH2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 3 LifeMap Cells Name Category PureStem™ progenitor EN7 (Embryonic Progenitor Cell)Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Matrigel embedded cells (Derivation of cardio... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See VASH2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VASH2 SOURCE GeneReport for Unigene cluster: Hs.96885 SABiosciences Custom PCR Arrays for VASH2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VASH2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat VASH2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VASH2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VASH2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASH2
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Orthologsfor VASH2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for VASH2 gene from 3/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for VASH2 (if available)TreeFam Gene Tree for VASH2 (if available)
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Paralogsfor VASH2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for VASH2 gene VASH1 2 1 SIMAP similar gene for VASH2 using alignment to 3 protein entries: VASH2_HUMAN (see all proteins ):VASH1
VASH2 for paralogs About GeneDecksing
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Genomic Variantsfor VASH2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for VASH2 (213123862 - 213165379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for VASH2 1 CNV : 71207
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VASH2
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Disorders
/ Diseasesfor VASH2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
VASH2 for disorders About MalaCards
VASH2 for disorders About GeneDecksing
OMIM gene information: 610471
OMIM disorders : --Export disorders for VASH2 gene to outside databases
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Publicationsfor VASH2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for VASH2 gene integrated from 9 sources : (articles sorted by number of sources associating them with VASH2) Utopia : connect your pdf to the dynamic world of online information
Isolation and characterization of vasohibin-2 as a homologue of VEGF- inducible endothelium-derived angiogenesis inhibitor vasohibin. (PubMed id 16528006) 1 , 2 , 3 Shibuya T....Sato Y. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Distinctive localization and opposed roles of vasohib in-1 and vasohibin-2 in the regulation of angiogenesis. (PubMed id 19204325) 1 Kimura H....Sato Y. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for VASH2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing VASH2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing VASH2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing VASH2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for VASH2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for VASH2 gene: Search GeneIP for patents involving VASH2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor VASH2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for VASH2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for VASH2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VASH2 OriGene Protein Over-expression Lysate for VASH2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for VASH2 OriGene 3'-UTR Clone for VASH2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VASH2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for VASH2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for VASH2 OriGene Custom Protein Services for VASH2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VASH2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VASH2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VASH2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat VASH2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VASH2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VASH2
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VASH2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VASH2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VASH2
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Aliases for VASH2
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Disorders / Diseases for VASH2
Domains / Families for VASH2
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Expression for VASH2
Function for VASH2
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Pathways / Interactions for VASH2
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Transcripts for VASH2
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