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Aliases for VASH2 Gene

Aliases for VASH2 Gene

  • Vasohibin 2 2 3 5
  • Vasohibin-Like Protein 3 4
  • Testicular Tissue Protein Li 222 3
  • Vasohibin-2 3
  • VASHL 4

External Ids for VASH2 Gene

Previous GeneCards Identifiers for VASH2 Gene

  • GC01P211190
  • GC01P213123
  • GC01P183798

Summaries for VASH2 Gene

GeneCards Summary for VASH2 Gene

VASH2 (Vasohibin 2) is a Protein Coding gene. An important paralog of this gene is VASH1.

UniProtKB/Swiss-Prot for VASH2 Gene

  • Angiogenesis inhibitor. Inhibits network formation by endothelial cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASH2 Gene

Genomics for VASH2 Gene

Regulatory Elements for VASH2 Gene

Enhancers for VASH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F212977 1.4 FANTOM5 Ensembl ENCODE 13.4 +44.6 44606 5.6 TBP CBX3 TBL1XR1 WRNIP1 BMI1 EGR1 ETV6 CREM EGR2 SMAD5 RPS6KC1 VASH2 BATF3 ANGEL2 TATDN3
GH01F212476 1.5 FANTOM5 Ensembl ENCODE 9.7 -457.8 -457771 1.7 PKNOX1 ATF1 WRNIP1 BRCA1 YY1 ELK1 GATA2 ZNF143 KLF13 ZNF263 LOC105372907 ATF3 NENF FLVCR1 ENSG00000235862 FAM71A BATF3 TMEM206 NEK2 ENSG00000212187
GH01F212789 1.2 ENCODE 11.2 -143.9 -143947 4.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 FLVCR1 FLVCR1-AS1 TATDN3 RPL21P28 LOC105372907 ENSG00000225233 LOC105372912 ANGEL2 RPS28P2 ENSG00000235182
GH01F212819 1.1 FANTOM5 Ensembl ENCODE 10.9 -115.8 -115843 1.4 PKNOX1 TBL1XR1 MTA2 IKZF1 TCF7 CREM RELA FLVCR1-AS1 ENSG00000235182 FLVCR1 RPS28P2 TATDN3 VASH2 BATF3 RPS5P4
GH01F212469 1.2 FANTOM5 Ensembl ENCODE 9.7 -465.3 -465263 1.3 ZNF687 JUND RAD51 RNF2 BHLHE40 FOXP2 FOS NENF ENSG00000235862 FAM71A ATF3 TMEM206 BATF3 LOC105372907 ENSG00000212187 VASH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VASH2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the VASH2 gene promoter:

Genomic Location for VASH2 Gene

Chromosome:
1
Start:
212,935,543 bp from pter
End:
212,992,037 bp from pter
Size:
56,495 bases
Orientation:
Plus strand

Genomic View for VASH2 Gene

Genes around VASH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH2 Gene

Proteins for VASH2 Gene

  • Protein details for VASH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V25-VASH2_HUMAN
    Recommended name:
    Vasohibin-2
    Protein Accession:
    Q86V25
    Secondary Accessions:
    • B4DYZ5
    • Q2VT46
    • Q5VTE7
    • Q5VTE9
    • Q7Z6E3
    • Q8IZ24
    • Q9H9W5

    Protein attributes for VASH2 Gene

    Size:
    355 amino acids
    Molecular mass:
    40450 Da
    Quaternary structure:
    • Interacts with SVBP; the interaction enhances VASH2 secretion.
    SequenceCaution:
    • Sequence=CAH71916.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71918.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VASH2 Gene

neXtProt entry for VASH2 Gene

Post-translational modifications for VASH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VASH2 Gene

Domains & Families for VASH2 Gene

Protein Domains for VASH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VASH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V25

UniProtKB/Swiss-Prot:

VASH2_HUMAN :
  • Belongs to the vasohibin family.
Family:
  • Belongs to the vasohibin family.
genes like me logo Genes that share domains with VASH2: view

No data available for Gene Families for VASH2 Gene

Function for VASH2 Gene

Molecular function for VASH2 Gene

UniProtKB/Swiss-Prot Function:
Angiogenesis inhibitor. Inhibits network formation by endothelial cells.
UniProtKB/Swiss-Prot Induction:
By VEGF.
genes like me logo Genes that share phenotypes with VASH2: view

Animal Models for VASH2 Gene

MGI Knock Outs for VASH2:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASH2 Gene

Localization for VASH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASH2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

Pathways & Interactions for VASH2 Gene

SuperPathways for VASH2 Gene

No Data Available

Interacting Proteins for VASH2 Gene

Selected Interacting proteins: Q86V25-VASH2_HUMAN for VASH2 Gene via IID

Symbol External ID(s) Details
APP
LRRK2

Gene Ontology (GO) - Biological Process for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000768 syncytium formation by plasma membrane fusion IEA --
GO:0001938 positive regulation of endothelial cell proliferation IDA 19204325
GO:0045026 plasma membrane fusion IMP 25184477
GO:0045765 regulation of angiogenesis IEA --
GO:0045766 positive regulation of angiogenesis IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

No data available for Pathways by source and SIGNOR curated interactions for VASH2 Gene

Transcripts for VASH2 Gene

Unigene Clusters for VASH2 Gene

Vasohibin 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for VASH2 Gene

GeneLoc Exon Structure for
VASH2
ECgene alternative splicing isoforms for
VASH2

Expression for VASH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VASH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VASH2 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for VASH2 Gene

This gene is overexpressed in Heart (55.9) and Adipocyte (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VASH2 Gene



Protein tissue co-expression partners for VASH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VASH2 Gene:

VASH2

SOURCE GeneReport for Unigene cluster for VASH2 Gene:

Hs.96885
genes like me logo Genes that share expression patterns with VASH2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for VASH2 Gene

Orthologs for VASH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASH2 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia VASH2 34 35
  • 93.68 (n)
mouse
(Mus musculus)
Mammalia Vash2 34 16 35
  • 90.14 (n)
rat
(Rattus norvegicus)
Mammalia Vash2 34
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia VASH2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VASH2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VASH2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASH2 34 35
  • 77.67 (n)
lizard
(Anolis carolinensis)
Reptilia VASH2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vash2 34
  • 71.2 (n)
zebrafish
(Danio rerio)
Actinopterygii vash2 34 35
  • 65.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for VASH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VASH2 Gene

ENSEMBL:
Gene Tree for VASH2 (if available)
TreeFam:
Gene Tree for VASH2 (if available)

Paralogs for VASH2 Gene

Paralogs for VASH2 Gene

(1) SIMAP similar genes for VASH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VASH2: view

Variants for VASH2 Gene

Sequence variations from dbSNP and Humsavar for VASH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10127459 -- 212,943,587(+) taatc(C/T)ccaat intron-variant
rs10399608 -- 212,956,095(+) CCTGG(A/G)GTTCT intron-variant
rs10494956 -- 212,977,450(+) AATGA(A/G)TGTTC intron-variant, nc-transcript-variant
rs10601750 -- 212,987,032(+) ATTTC(-/AGAG)AGAGA intron-variant
rs10701449 -- 212,976,580(+) AAAAA(-/A/AA/AAG/AT)TGGTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VASH2 Gene

Variant ID Type Subtype PubMed ID
esv3307325 CNV mobile element insertion 20981092
esv29349 CNV gain 19812545

Variation tolerance for VASH2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASH2 Gene

Disorders for VASH2 Gene

Relevant External Links for VASH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASH2

No disorders were found for VASH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASH2 Gene

Publications for VASH2 Gene

  1. Isolation and characterization of vasohibin-2 as a homologue of VEGF- inducible endothelium-derived angiogenesis inhibitor vasohibin. (PMID: 16528006) Shibuya T. … Sato Y. (Arterioscler. Thromb. Vasc. Biol. 2006) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Expression of vasohibin-2 in pancreatic ductal adenocarcinoma promotes tumor progression and is associated with a poor clinical outcome. (PMID: 25916042) Kim J.C. … Kim H.S. (Hepatogastroenterology 2015) 3 64

Products for VASH2 Gene

Sources for VASH2 Gene

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