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Aliases for VASH2 Gene

Aliases for VASH2 Gene

  • Vasohibin 2 2 3
  • Vasohibin-Like Protein 4
  • VASHL 4

External Ids for VASH2 Gene

Previous GeneCards Identifiers for VASH2 Gene

  • GC01P211190
  • GC01P213123
  • GC01P183798

Summaries for VASH2 Gene

GeneCards Summary for VASH2 Gene

VASH2 (Vasohibin 2) is a Protein Coding gene. An important paralog of this gene is VASH1.

UniProtKB/Swiss-Prot for VASH2 Gene

  • Angiogenesis inhibitor. Inhibits network formation by endothelial cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASH2 Gene

Genomics for VASH2 Gene

Regulatory Elements for VASH2 Gene

Transcription factor binding sites by QIAGEN in the VASH2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VASH2 Gene

Chromosome:
1
Start:
212,935,543 bp from pter
End:
212,992,037 bp from pter
Size:
56,495 bases
Orientation:
Plus strand

Genomic View for VASH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VASH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH2 Gene

Proteins for VASH2 Gene

  • Protein details for VASH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V25-VASH2_HUMAN
    Recommended name:
    Vasohibin-2
    Protein Accession:
    Q86V25
    Secondary Accessions:
    • B4DYZ5
    • Q2VT46
    • Q5VTE7
    • Q5VTE9
    • Q7Z6E3
    • Q8IZ24
    • Q9H9W5

    Protein attributes for VASH2 Gene

    Size:
    355 amino acids
    Molecular mass:
    40450 Da
    Quaternary structure:
    • Interacts with SVBP; the interaction enhances VASH2 secretion.
    SequenceCaution:
    • Sequence=CAH71916.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71918.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VASH2 Gene

neXtProt entry for VASH2 Gene

Proteomics data for VASH2 Gene at MOPED

Post-translational modifications for VASH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for VASH2 Gene

Domains & Families for VASH2 Gene

Protein Domains for VASH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VASH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V25

UniProtKB/Swiss-Prot:

VASH2_HUMAN :
  • Belongs to the vasohibin family.
Family:
  • Belongs to the vasohibin family.
genes like me logo Genes that share domains with VASH2: view

No data available for Gene Families for VASH2 Gene

Function for VASH2 Gene

Molecular function for VASH2 Gene

UniProtKB/Swiss-Prot Function:
Angiogenesis inhibitor. Inhibits network formation by endothelial cells.
UniProtKB/Swiss-Prot Induction:
By VEGF.

Phenotypes for VASH2 Gene

genes like me logo Genes that share phenotypes with VASH2: view

Animal Models for VASH2 Gene

MGI Knock Outs for VASH2:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VASH2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for VASH2 Gene

Localization for VASH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASH2 Gene COMPARTMENTS Subcellular localization image for VASH2 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

Pathways & Interactions for VASH2 Gene

SuperPathways for VASH2 Gene

No Data Available

Interacting Proteins for VASH2 Gene

Gene Ontology (GO) - Biological Process for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19204325
GO:0045765 regulation of angiogenesis --
GO:0045766 positive regulation of angiogenesis IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

No data available for Pathways by source and SIGNOR curated interactions for VASH2 Gene

Drugs & Compounds for VASH2 Gene

No Compound Related Data Available

Transcripts for VASH2 Gene

Unigene Clusters for VASH2 Gene

Vasohibin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VASH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for VASH2 Gene

GeneLoc Exon Structure for
VASH2
ECgene alternative splicing isoforms for
VASH2

Expression for VASH2 Gene

mRNA expression in normal human tissues for VASH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VASH2 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for VASH2 Gene

This gene is overexpressed in Heart (55.9) and Adipocyte (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VASH2 Gene



SOURCE GeneReport for Unigene cluster for VASH2 Gene Hs.96885

genes like me logo Genes that share expression patterns with VASH2: view

Protein tissue co-expression partners for VASH2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for VASH2 Gene

Orthologs for VASH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VASH2 35
  • 93.68 (n)
  • 98.39 (a)
VASH2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vash2 35
  • 90.14 (n)
  • 96.78 (a)
Vash2 16
Vash2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VASH2 35
  • 99.36 (n)
  • 100 (a)
VASH2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vash2 35
  • 88.13 (n)
  • 90.91 (a)
cow
(Bos Taurus)
Mammalia VASH2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VASH2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VASH2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASH2 35
  • 77.67 (n)
  • 85.44 (a)
VASH2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VASH2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vash2 35
  • 71.2 (n)
  • 72.47 (a)
zebrafish
(Danio rerio)
Actinopterygii vash2 35
  • 65.53 (n)
  • 67.17 (a)
vash2 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for VASH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VASH2 Gene

ENSEMBL:
Gene Tree for VASH2 (if available)
TreeFam:
Gene Tree for VASH2 (if available)

Paralogs for VASH2 Gene

Paralogs for VASH2 Gene

(1) SIMAP similar genes for VASH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VASH2: view

Variants for VASH2 Gene

Sequence variations from dbSNP and Humsavar for VASH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs903802 -- 212,942,179(+) AGAAG(C/G)CTACG intron-variant
rs903803 -- 212,958,659(+) CCCAC(A/G)CTTAC intron-variant
rs949932 -- 212,937,893(-) TGGGA(C/T)AGGGA intron-variant
rs975558 -- 212,982,790(+) TTCTC(C/T)TGGGT intron-variant
rs2101877 -- 212,935,628(+) gattc(A/G)ttctt utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for VASH2 Gene

Variant ID Type Subtype PubMed ID
esv29349 CNV Gain 19812545
esv271601 CNV Insertion 20981092

Variation tolerance for VASH2 Gene

Residual Variation Intolerance Score: 40.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASH2 Gene

HapMap Linkage Disequilibrium report
VASH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASH2 Gene

Disorders for VASH2 Gene

Relevant External Links for VASH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASH2
genes like me logo Genes that share disorders with VASH2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASH2 Gene

Publications for VASH2 Gene

  1. Isolation and characterization of vasohibin-2 as a homologue of VEGF- inducible endothelium-derived angiogenesis inhibitor vasohibin. (PMID: 16528006) Shibuya T. … Sato Y. (Arterioscler. Thromb. Vasc. Biol. 2006) 2 67
  2. Expression of vasohibin-2 in pancreatic ductal adenocarcinoma promotes tumor progression and is associated with a poor clinical outcome. (PMID: 25916042) Kim J.C. … Kim H.S. (Hepatogastroenterology 2015) 67
  3. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. (PMID: 25184477) Suenaga K. … Sato Y. (PLoS ONE 2014) 67
  4. Vasohibin 2 decreases the cisplatin sensitivity of hepatocarcinoma cell line by downregulating p53. (PMID: 24595063) Li Z. … Gao W. (PLoS ONE 2014) 67
  5. Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. (PMID: 23548203) Zhang M. … Han J. (Hum. Mol. Genet. 2013) 67

Products for VASH2 Gene

Sources for VASH2 Gene

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