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VASH2 Gene

protein-coding GIFtS: 38

GC01P211190

vasohibin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ12505 ^¹, ²
RP11-275G3.1 ^²
VASHL ^³

Descriptions
Vasohibin-like protein ^³
vasohibin 2 ^²

External Ids
HGNC: 25723¹
Entrez Gene: 79805²
UniProtKB: Q86V25³
Ensembl: ENSG00000143494⁷

Search outside databases for aliases for VASH2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25

Function: Angiogenesis inhibitor. Inhibits network formation by endothelial cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VASH2 gene

Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q23

VASH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P211190: (about GC identifiers)

Start:	211,190,477 bp from pter
End:	211,231,550 bp from pter
Size:	41,074 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25 (See protein sequence)

Recommended Name: Vasohibin-2

Size: 355 amino acids; 40450 Da

Developmental stage: Expressed in various embryonic organs at 6 to 12 embryonic weeks. Detected in

vessels from 20-week embryonic organs as well as in endothelial cells from large vessels in

neonate

Secondary accessions: Q2VT46 Q5VTE7 Q5VTE9 Q7Z6E3 Q8IZ24 Q9H9W5

Alternative splicing: 5 isoforms: Q86V25-1 Q86V25-2 Q86V25-3 Q86V25-4 Q86V25-5

REFSEQ proteins (3 alternative transcripts):

NP_001129946.1 NP_001129947.1 NP_079025.2

ENSEMBL proteins:

ENSP00000271776 ENSP00000344587 ENSP00000355935 ENSP00000355936 ENSP00000355934 ENSP00000355932

ENSP00000355933 ENSP00000355931

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: VASH2

Antibodies for VASH2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VASH2

Assays for VASH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q86V25

UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25

Similarity: Belongs to the vasohibin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VASH2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_024749

Applied Biosystems Silencer® siRNAs for VASH2

Sigma-Aldrich siRNA for VASH2

Sigma-Aldrich shRNA for VASH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VASH2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136474
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136474
untagged cDNA clones in CMV expression vector (see all 5): BC028194

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024749

UniProtKB/Swiss-Prot: VASH2_HUMAN, Q86V25

Function: Angiogenesis inhibitor. Inhibits network formation by endothelial cells

Induction: By VEGF

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Vash2):

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VASH2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VASH2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_024749

Sigma-Aldrich siRNA for VASH2

Sigma-Aldrich shRNA for VASH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136474 NM_001136475 NM_024749

REFSEQ mRNAs for VASH2 gene (3 alternative transcripts):

NM_001136474.1 NM_001136475.1 NM_024749.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136474 NM_001136475 NM_024749

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136474
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136474
                                 untagged cDNA clones in CMV expression vector (see all 5): BC028194

Additional cDNA sequence:

AK022567.1 AK096605.1 AK290973.1 AK302675.1 AY834202.1 BC051856.1

8 DOTS entries:

DT.100018664 DT.91661796 DT.121412716 DT.100710908 DT.100754549 DT.121412694 DT.91657694 DT.95260350

24/55 AceView cDNA sequences (see all 55 ):

AW959420 AI291607 BE350485 AU124123 AA626409 BC028194 AI126990 AI198593

AU121363 AK022567 BC051856 NM_024749 AI192696 AA301175 BC053836 AI400615

BP368754 CB990557 BQ223577 AW169104 AA025824 CF593746 BM471150 AI961235

highest scoring ESTs for VASH2:

AA885478 AA025824 AA081791 AA301175 AA347615 AA424230 AA626409 AI126990 AI198593 AI285984

Unigene Cluster for VASH2:

Vasohibin 2

Hs.96885 [show with all ESTs]

Unigene Representative Sequence: NM_024749

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 (see all 6 )

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11
SP1:			-				-		-		-				-				-										-				-
SP2:			-		-		-		-		-		-		-						-
SP3:															-				-
SP4:							-		-		-
SP5:			-

About this scheme

ECgene alternative splicing isoforms for VASH2

8 Ensembl transcripts including schematic representations:

ENST00000271776 ENST00000343712 ENST00000366968 ENST00000366969 ENST00000366967 ENST00000366965

ENST00000366966 ENST00000366964

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VASH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VASH2

¹ / ² / ³

7 probe-sets matching VASH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76403_at²^{, 3}	U95-E	1	1.00	1.00	0.66	1.12	AA885478	1.00	1.00	1.00	1
52859_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.00	AI961235	0.60	1.00	0.82	1
235343_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI961235	0.60	1.00	0.82	1
219740_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024749	0.60	1.00	0.82	1
235343_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555092_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219740_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VASH2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGACTTTAAT

SOURCE GeneReport for Unigene cluster: Hs.96885

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VASH2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VASH2¹	--	vasohibin 2	93.78(n) 98.39(a)	608015 XM_844064.1 XP_849157.1
chimpanzee (Pan troglodytes)	VASH2¹	--	vasohibin 2	99.14(n) 99.68(a)	469677 XM_001170898.1 XP_001170898.1
cow (Bos taurus)	VASH2¹	--	vasohibin 2	93.98(n) 98.26(a)	539085 XM_001250747.1 XP_001250748.1
rat (Rattus norvegicus)	Vash2¹	--	vasohibin 2	89.42(n) 96.3(a)	498309 XM_573538.2 XP_573538.2
mouse (Mus musculus)	Vash2^{1, 5}	1⁵	vasohibin 2^{1, 5}	89.16(n)¹ 96.75(a)¹	226841¹ NM_144879.1¹ NP_659128.1¹ AI451539⁵ AK045261⁵ (see all 12)

About this table Species with no ortholog for VASH2

ENSEMBL Gene Tree for VASH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VASH2 gene

VASH1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/243 NCBI SNPs in VASH2 are shown (see all 243 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10864033^1,2	A,C,F,H	211230706(+)	`CCTTGA/GTTTTT`	3	--	ut3¹		12		EU EA WA	1256
	rs3010779^1,2	A,C,F,H	211228769(+)	`GGTTGG/AACTAT`	3	--	ut3¹ ese³		4		EU EA WA	412
	rs3010780^1,2	C,F	211231541(+)	`ATCCTG/AGAAAC`	3	--	ut3¹		4		NA EA	362
--	rs3123305^1,2	A	211191494(+)	`TCCCCA/GCCCAG`	1	--	ut5¹ ese³		0	--	--	--	--
	rs11120072^1,2	H	211228804(+)	`TAACCG/ATAACT`	3	--	ut3¹		4		EU EA WA	414
	rs10746440^1,2	A,C,F,H	211211987(+)	`TCCCAG/CGCTTG`	1	--	int¹		3		EA WA	298
	rs2935216^1,2	A,C,F,H	211209079(+)	`GGTGGA/GGAGCT`	1	--	int¹		8		EU EA WA NA	774
	rs10735511^1,2	A,C,F,H	211212145(+)	`ATACCT/AAAGCT`	1	--	int¹		4		EU EA WA	416
	rs3104213^1,2	A,C,F,H	211202771(+)	`GTCTGG/CTGTTT`	1	--	int¹		8		EU EA WA	802
	rs11120070^1,2	A,C,F,H	211222189(+)	`CAGGTG/TAGGCT`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for VASH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610471

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for VASH2 gene:

Isolation and characterization of vasohibin-2 as a homologue of VEGF- inducible endothelium-derived angiogenesis inhibitor vasohibin. (PubMed id 16528006)^{2, 3, 4} Shibuya T....Sato Y. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79805	HGNC: 25723	AceView: FLJ12505	Ensembl:ENSG00000143494	euGenes: HUgn79805
ECgene: VASH2	H-InvDB: VASH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for VASH2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VASH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VASH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VASH2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VASH2		Browse small molecules at Sigma-Aldrich
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VASH2 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for VASH2

Summaries
for VASH2

Genomic Location
for VASH2

Proteins
for VASH2

Protein Domains/
Families
for VASH2

Gene Function
for VASH2

Pathways & Interactions
for VASH2

Drugs & Compounds
for VASH2

Transcripts
for VASH2

Expression
for VASH2

Orthologs
for VASH2

Paralogs
for VASH2

SNPs/Variants
for VASH2

Disorders & Mutations
for VASH2

Medical News
for VASH2

Publications
for VASH2

Search for VASH2

Genome Databases showing VASH2

Other Databases showing VASH2

Specialized Databases showing VASH2

Licensable Technologies
for VASH2

Services
for VASH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VASH2 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor VASH2

Summariesfor VASH2

Genomic Locationfor VASH2

Proteinsfor VASH2

Protein Domains/Familiesfor VASH2

Gene Functionfor VASH2

Pathways & Interactionsfor VASH2

Drugs & Compoundsfor VASH2

Transcriptsfor VASH2

Expression for VASH2

Orthologsfor VASH2

Paralogsfor VASH2

SNPs/Variantsfor VASH2

Disorders & Mutationsfor VASH2

Medical Newsfor VASH2

Publicationsfor VASH2

Search for VASH2

Genome Databases showing VASH2

Other Databases showing VASH2

Specialized Databases showing VASH2

Licensable Technologiesfor VASH2

Servicesfor VASH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VASH2

Summaries
for VASH2

Genomic Location
for VASH2

Proteins
for VASH2

Protein Domains/
Families
for VASH2

Gene Function
for VASH2

Pathways & Interactions
for VASH2

Drugs & Compounds
for VASH2

Transcripts
for VASH2

Expression
for VASH2

Orthologs
for VASH2

Paralogs
for VASH2

SNPs/Variants
for VASH2

Disorders & Mutations
for VASH2

Medical News
for VASH2

Publications
for VASH2

Licensable Technologies
for VASH2

Services
for VASH2