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Aliases for VASH2 Gene

Aliases for VASH2 Gene

  • Vasohibin 2 2 3 5
  • Vasohibin-Like Protein 3 4
  • Testicular Tissue Protein Li 222 3
  • Vasohibin-2 3
  • VASHL 4

External Ids for VASH2 Gene

Previous GeneCards Identifiers for VASH2 Gene

  • GC01P211190
  • GC01P213123
  • GC01P183798

Summaries for VASH2 Gene

GeneCards Summary for VASH2 Gene

VASH2 (Vasohibin 2) is a Protein Coding gene. An important paralog of this gene is VASH1.

UniProtKB/Swiss-Prot for VASH2 Gene

  • Angiogenesis inhibitor. Inhibits network formation by endothelial cells.

Additional gene information for VASH2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASH2 Gene

Genomics for VASH2 Gene

Regulatory Elements for VASH2 Gene

Enhancers for VASH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H212977 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +44.6 44606 5.6 HDAC1 FOXA2 TBL1XR1 RB1 BMI1 BATF ZNF207 ATF7 ETV6 RUNX3 RPS6KC1 VASH2 BATF3 ANGEL2 TATDN3
GH01H212476 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -457.8 -457771 1.7 PKNOX1 ATF1 BRCA1 ZNF766 GATA2 ELK1 ZNF143 ATF7 RUNX3 CAVIN1 LOC105372907 ATF3 NENF ENSG00000235862 FAM71A BATF3 TMEM206 RPL21P28 ENSG00000212187 VASH2
GH01H212469 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -465.3 -465263 1.3 ZNF687 L3MBTL2 NRF1 USF2 DPF2 RAD21 FOSL1 JUND FOXP2 FOS NENF FAM71A ENSG00000235862 ATF3 TMEM206 BATF3 LOC105372907 ENSG00000212187 VASH2
GH01H212789 1.2 ENCODE 11.2 -143.9 -143947 4.4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A ZFP41 FLVCR1 FLVCR1-AS1 ANGEL2 TATDN3 LOC105372907 ENSG00000225233 LOC105372912 RPS28P2 ENSG00000235182 RPL21P28
GH01H212819 1.2 FANTOM5 Ensembl ENCODE 10.9 -115.8 -115778 1.1 ZNF217 PKNOX1 TBL1XR1 NR2F1 IKZF1 BATF CREM IKZF2 RELA FLVCR1-AS1 ENSG00000235182 FLVCR1 RPS28P2 TATDN3 VASH2 BATF3 RPS5P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VASH2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the VASH2 gene promoter:

Genomic Locations for VASH2 Gene

Genomic Locations for VASH2 Gene
56,495 bases
Plus strand

Genomic View for VASH2 Gene

Genes around VASH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH2 Gene

Proteins for VASH2 Gene

  • Protein details for VASH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DYZ5
    • Q2VT46
    • Q5VTE7
    • Q5VTE9
    • Q7Z6E3
    • Q8IZ24
    • Q9H9W5

    Protein attributes for VASH2 Gene

    355 amino acids
    Molecular mass:
    40450 Da
    Quaternary structure:
    • Interacts with SVBP; the interaction enhances VASH2 secretion.
    • Sequence=CAH71916.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71918.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VASH2 Gene

neXtProt entry for VASH2 Gene

Post-translational modifications for VASH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VASH2 Gene

Domains & Families for VASH2 Gene

Gene Families for VASH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VASH2 Gene


Suggested Antigen Peptide Sequences for VASH2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vasohibin family.
  • Belongs to the vasohibin family.
genes like me logo Genes that share domains with VASH2: view

Function for VASH2 Gene

Molecular function for VASH2 Gene

UniProtKB/Swiss-Prot Function:
Angiogenesis inhibitor. Inhibits network formation by endothelial cells.
UniProtKB/Swiss-Prot Induction:

Phenotypes From GWAS Catalog for VASH2 Gene

genes like me logo Genes that share phenotypes with VASH2: view

Animal Models for VASH2 Gene

MGI Knock Outs for VASH2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASH2 Gene

Localization for VASH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASH2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

Pathways & Interactions for VASH2 Gene

SuperPathways for VASH2 Gene

No Data Available

Interacting Proteins for VASH2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86V25-VASH2_HUMAN ENSP00000355932 for VASH2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000768 syncytium formation by plasma membrane fusion IEA --
GO:0001938 positive regulation of endothelial cell proliferation IDA 19204325
GO:0045026 plasma membrane fusion IMP 25184477
GO:0045765 regulation of angiogenesis IEA --
GO:0045766 positive regulation of angiogenesis IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

No data available for Pathways by source and SIGNOR curated interactions for VASH2 Gene

Drugs & Compounds for VASH2 Gene

No Compound Related Data Available

Transcripts for VASH2 Gene

Unigene Clusters for VASH2 Gene

Vasohibin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for VASH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VASH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VASH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VASH2 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for VASH2 Gene

This gene is overexpressed in Heart (55.9) and Adipocyte (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VASH2 Gene

Protein tissue co-expression partners for VASH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VASH2 Gene:


SOURCE GeneReport for Unigene cluster for VASH2 Gene:


Evidence on tissue expression from TISSUES for VASH2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with VASH2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VASH2 Gene

Orthologs for VASH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VASH2 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia VASH2 33 34
  • 93.68 (n)
(Mus musculus)
Mammalia Vash2 16 34 33
  • 90.14 (n)
(Rattus norvegicus)
Mammalia Vash2 33
  • 88.13 (n)
(Bos Taurus)
Mammalia VASH2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia VASH2 34
  • 76 (a)
(Monodelphis domestica)
Mammalia VASH2 34
  • 70 (a)
(Gallus gallus)
Aves VASH2 34 33
  • 77.67 (n)
(Anolis carolinensis)
Reptilia VASH2 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vash2 33
  • 71.2 (n)
(Danio rerio)
Actinopterygii vash2 33 34
  • 65.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for VASH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VASH2 Gene

Gene Tree for VASH2 (if available)
Gene Tree for VASH2 (if available)

Paralogs for VASH2 Gene

Paralogs for VASH2 Gene

(1) SIMAP similar genes for VASH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VASH2: view

Variants for VASH2 Gene

Sequence variations from dbSNP and Humsavar for VASH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000016203 -- 212,949,214(+) TAATT(C/T)CTGGC intron-variant, upstream-variant-2KB
rs1000021234 -- 212,934,766(+) AGAAG(A/G)CTTGA upstream-variant-2KB
rs1000025293 -- 212,975,179(+) CTGAT(C/T)CTGGG intron-variant, utr-variant-3-prime
rs1000033660 -- 212,961,639(+) GCTTT(G/T)TCACC intron-variant
rs1000065266 -- 212,960,447(+) GGGGG(G/T)GGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VASH2 Gene

Variant ID Type Subtype PubMed ID
esv3307325 CNV mobile element insertion 20981092
esv29349 CNV gain 19812545

Variation tolerance for VASH2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASH2 Gene

Disorders for VASH2 Gene

Relevant External Links for VASH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VASH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASH2 Gene

Publications for VASH2 Gene

  1. Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. (PMID: 16528006) Shibuya T … Sato Y (Arteriosclerosis, thrombosis, and vascular biology 2006) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for VASH2 Gene

Sources for VASH2 Gene

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