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Aliases for VASH1 Gene

Aliases for VASH1 Gene

  • Vasohibin 1 2 3 5
  • KIAA1036 2 3 4
  • Vasohibin-1 3
  • VASH 4

External Ids for VASH1 Gene

Previous HGNC Symbols for VASH1 Gene

  • KIAA1036

Previous GeneCards Identifiers for VASH1 Gene

  • GC14P076299
  • GC14P077228
  • GC14P057396

Summaries for VASH1 Gene

GeneCards Summary for VASH1 Gene

VASH1 (Vasohibin 1) is a Protein Coding gene. An important paralog of this gene is VASH2.

UniProtKB/Swiss-Prot for VASH1 Gene

  • Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.

Gene Wiki entry for VASH1 Gene

Additional gene information for VASH1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASH1 Gene

Genomics for VASH1 Gene

Regulatory Elements for VASH1 Gene

Enhancers for VASH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H076715 1.3 FANTOM5 Ensembl ENCODE 74.6 -46.0 -45989 1.8 MTA2 TAL1 FOSL1 TCF12 POLR2A NCOR1 EGR1 KLF16 SMARCA4 ZNF584 VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC100130048
GH14H076719 1.1 Ensembl ENCODE 76.4 -41.6 -41569 2 NFIB BATF THRB RARA ETV6 RUNX3 IKZF2 JUNB NR2F2 NFIC VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC100130048
GH14H076949 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +194.7 194660 13.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC GLIS1 LINC01629 IRF2BPL VASH1 ENSG00000243225 ENSG00000259081 ANGEL1 LRRC74A ENSG00000259058
GH14H076771 1.3 Ensembl ENCODE dbSUPER 13.9 +11.6 11581 3.3 PKNOX1 NFRKB BMI1 ELK1 EGR1 FOS EGR2 NR2F2 RFX3 ZNF341 VASH1 ENSG00000259081 VASH1-AS1 ENSG00000258610
GH14H076767 1.4 Ensembl ENCODE dbSUPER 11.5 +6.6 6594 2.2 PKNOX1 ZFP64 BATF TCF12 RUNX3 CREM IKZF2 ZC3H11A REST ELF1 VIPAS39 SNW1 ZMYND19P1 ALKBH1 IRF2BPL GPATCH2L RPL22P2 POMT2 ENSG00000259081 VASH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VASH1 on UCSC Golden Path with GeneCards custom track

Promoters for VASH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071050 108 1601 LEF1 MXI1 BACH1 SIN3A ZIC2 E2F1 ZFHX2 GLIS2 POLR2A EED

Genomic Locations for VASH1 Gene

Genomic Locations for VASH1 Gene
chr14:76,761,892-76,783,022
(GRCh38/hg38)
Size:
21,131 bases
Orientation:
Plus strand
chr14:77,228,235-77,249,363
(GRCh37/hg19)

Genomic View for VASH1 Gene

Genes around VASH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH1 Gene

Proteins for VASH1 Gene

  • Protein details for VASH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8A9-VASH1_HUMAN
    Recommended name:
    Vasohibin-1
    Protein Accession:
    Q7L8A9
    Secondary Accessions:
    • Q96H02
    • Q9UBF4
    • Q9Y629

    Protein attributes for VASH1 Gene

    Size:
    365 amino acids
    Molecular mass:
    40957 Da
    Quaternary structure:
    • Interacts with SVBP; the interaction enhances VASH1 solubility and secretion and prevents its ubiquitination.
    SequenceCaution:
    • Sequence=AAD44361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA82988.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VASH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VASH1 Gene

Post-translational modifications for VASH1 Gene

  • 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.
  • Ubiquitinated in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VASH1 Gene

Antibody Products

  • Abcam antibodies for VASH1

No data available for DME Specific Peptides for VASH1 Gene

Domains & Families for VASH1 Gene

Gene Families for VASH1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VASH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VASH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L8A9

UniProtKB/Swiss-Prot:

VASH1_HUMAN :
  • Belongs to the vasohibin family.
Family:
  • Belongs to the vasohibin family.
genes like me logo Genes that share domains with VASH1: view

Function for VASH1 Gene

Molecular function for VASH1 Gene

UniProtKB/Swiss-Prot Function:
Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.
UniProtKB/Swiss-Prot Induction:
By VEGF.

Phenotypes From GWAS Catalog for VASH1 Gene

Gene Ontology (GO) - Molecular Function for VASH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with VASH1: view

Phenotypes for VASH1 Gene

MGI mutant phenotypes for VASH1:
inferred from 1 alleles
GenomeRNAi human phenotypes for VASH1:
genes like me logo Genes that share phenotypes with VASH1: view

Animal Models for VASH1 Gene

MGI Knock Outs for VASH1:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASH1 Gene

Localization for VASH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASH1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for VASH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15467828
GO:0005737 cytoplasm IDA 15467828
GO:0005783 endoplasmic reticulum IDA 15467828
GO:0045177 apical part of cell IDA 20736312
genes like me logo Genes that share ontologies with VASH1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VASH1 Gene

Pathways & Interactions for VASH1 Gene

SuperPathways for VASH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 15467828
GO:0001937 negative regulation of endothelial cell proliferation IDA,IEA 15467828
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0009611 response to wounding IDA 23056314
genes like me logo Genes that share ontologies with VASH1: view

No data available for Pathways by source and SIGNOR curated interactions for VASH1 Gene

Drugs & Compounds for VASH1 Gene

(1) Additional Compounds for VASH1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VASH1: view

Transcripts for VASH1 Gene

Unigene Clusters for VASH1 Gene

Vasohibin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASH1 Gene

No ASD Table

Relevant External Links for VASH1 Gene

GeneLoc Exon Structure for
VASH1
ECgene alternative splicing isoforms for
VASH1

Expression for VASH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VASH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASH1 Gene

This gene is overexpressed in Fetal Brain (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VASH1 Gene



Protein tissue co-expression partners for VASH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VASH1 Gene:

VASH1

SOURCE GeneReport for Unigene cluster for VASH1 Gene:

Hs.525479

mRNA Expression by UniProt/SwissProt for VASH1 Gene:

Q7L8A9-VASH1_HUMAN
Tissue specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.

Evidence on tissue expression from TISSUES for VASH1 Gene

  • Nervous system(4.5)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with VASH1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VASH1 Gene

Orthologs for VASH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASH1 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia VASH1 33 34
  • 94.67 (n)
cow
(Bos Taurus)
Mammalia VASH1 33 34
  • 93.02 (n)
oppossum
(Monodelphis domestica)
Mammalia VASH1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vash1 33 16 34
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Vash1 33
  • 88.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VASH1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASH1 33 34
  • 83.1 (n)
lizard
(Anolis carolinensis)
Reptilia VASH1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vash1 33
  • 66.99 (n)
zebrafish
(Danio rerio)
Actinopterygii VASH1 34
  • 73 (a)
OneToOne
LOC100001748 33
  • 72.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5764 33
Species where no ortholog for VASH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VASH1 Gene

ENSEMBL:
Gene Tree for VASH1 (if available)
TreeFam:
Gene Tree for VASH1 (if available)

Paralogs for VASH1 Gene

Paralogs for VASH1 Gene

(1) SIMAP similar genes for VASH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VASH1: view

Variants for VASH1 Gene

Sequence variations from dbSNP and Humsavar for VASH1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000052445 -- 76,776,526(+) GAATC(A/G)CGGCC intron-variant
rs1000104062 -- 76,767,263(+) ATAAA(G/T)AAATA intron-variant
rs1000214828 -- 76,781,825(+) TCTGG(A/G)GGCTG nc-transcript-variant, utr-variant-3-prime
rs1000489191 -- 76,776,282(+) TGCCC(A/G)CCTTC intron-variant
rs1000575931 -- 76,777,495(+) AAGCT(C/G)ACGGT intron-variant

Variation tolerance for VASH1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VASH1 Gene

Disorders for VASH1 Gene

Relevant External Links for VASH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASH1

No disorders were found for VASH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASH1 Gene

Publications for VASH1 Gene

  1. Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin. (PMID: 16488400) Sonoda H … Sato Y (Biochemical and biophysical research communications 2006) 3 4 22 60
  2. Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. (PMID: 16707096) Yamashita H … Sato Y (Biochemical and biophysical research communications 2006) 3 4 22 60
  3. Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells. (PMID: 15649403) Shimizu K … Sato Y (Biochemical and biophysical research communications 2005) 3 4 22 60
  4. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. (PMID: 15467828) Watanabe K … Sato Y (The Journal of clinical investigation 2004) 3 4 22 60
  5. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. (PMID: 20736312) Suzuki Y … Sato Y (Journal of cell science 2010) 3 4 60

Products for VASH1 Gene

Sources for VASH1 Gene

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