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Aliases for VASH1 Gene

Aliases for VASH1 Gene

  • Vasohibin 1 2 3 5
  • KIAA1036 2 3 4
  • VASH 4

External Ids for VASH1 Gene

Previous HGNC Symbols for VASH1 Gene

  • KIAA1036

Previous GeneCards Identifiers for VASH1 Gene

  • GC14P076299
  • GC14P077228
  • GC14P057396

Summaries for VASH1 Gene

GeneCards Summary for VASH1 Gene

VASH1 (Vasohibin 1) is a Protein Coding gene. An important paralog of this gene is VASH2.

UniProtKB/Swiss-Prot for VASH1 Gene

  • Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.

Gene Wiki entry for VASH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VASH1 Gene

Genomics for VASH1 Gene

Regulatory Elements for VASH1 Gene

Promoters for VASH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VASH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VASH1 Gene

Chromosome:
14
Start:
76,761,892 bp from pter
End:
76,783,022 bp from pter
Size:
21,131 bases
Orientation:
Plus strand

Genomic View for VASH1 Gene

Genes around VASH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH1 Gene

Proteins for VASH1 Gene

  • Protein details for VASH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8A9-VASH1_HUMAN
    Recommended name:
    Vasohibin-1
    Protein Accession:
    Q7L8A9
    Secondary Accessions:
    • Q96H02
    • Q9UBF4
    • Q9Y629

    Protein attributes for VASH1 Gene

    Size:
    365 amino acids
    Molecular mass:
    40957 Da
    Quaternary structure:
    • Interacts with SVBP; the interaction enhances VASH1 solubility and secretion and prevents its ubiquitination.
    SequenceCaution:
    • Sequence=AAD44361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA82988.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VASH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VASH1 Gene

Proteomics data for VASH1 Gene at MOPED

Post-translational modifications for VASH1 Gene

  • 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.
  • Ubiquitinated in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VASH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VASH1 Gene

Domains & Families for VASH1 Gene

Protein Domains for VASH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VASH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L8A9

UniProtKB/Swiss-Prot:

VASH1_HUMAN :
  • Belongs to the vasohibin family.
Family:
  • Belongs to the vasohibin family.
genes like me logo Genes that share domains with VASH1: view

No data available for Gene Families for VASH1 Gene

Function for VASH1 Gene

Molecular function for VASH1 Gene

UniProtKB/Swiss-Prot Function:
Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.
UniProtKB/Swiss-Prot Induction:
By VEGF.

Phenotypes for VASH1 Gene

MGI mutant phenotypes for VASH1:
inferred from 1 alleles
GenomeRNAi human phenotypes for VASH1:
genes like me logo Genes that share phenotypes with VASH1: view

Animal Models for VASH1 Gene

MGI Knock Outs for VASH1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASH1 Gene

Localization for VASH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VASH1 Gene COMPARTMENTS Subcellular localization image for VASH1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VASH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15467828
genes like me logo Genes that share ontologies with VASH1: view

Pathways & Interactions for VASH1 Gene

SuperPathways for VASH1 Gene

No Data Available

Interacting Proteins for VASH1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000167106%0d%0a9606.ENSP00000361599%0d%0a9606.ENSP00000210060%0d%0a
Selected Interacting proteins: ENSP00000167106 Q7L8A9-VASH1_HUMAN for VASH1 Gene via STRING I2D UniProtKB

Gene Ontology (GO) - Biological Process for VASH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 15467828
GO:0001937 negative regulation of endothelial cell proliferation IDA 15467828
GO:0007050 cell cycle arrest IEA --
GO:0009611 response to wounding IDA 23056314
GO:0010596 negative regulation of endothelial cell migration IGI 20736312
genes like me logo Genes that share ontologies with VASH1: view

No data available for Pathways by source and SIGNOR curated interactions for VASH1 Gene

Drugs & Compounds for VASH1 Gene

(1) Additional Compounds for VASH1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VASH1: view

Transcripts for VASH1 Gene

Unigene Clusters for VASH1 Gene

Vasohibin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VASH1 Gene

No ASD Table

Relevant External Links for VASH1 Gene

GeneLoc Exon Structure for
VASH1
ECgene alternative splicing isoforms for
VASH1

Expression for VASH1 Gene

mRNA expression in normal human tissues for VASH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASH1 Gene

This gene is overexpressed in Fetal Brain (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VASH1 Gene



SOURCE GeneReport for Unigene cluster for VASH1 Gene Hs.525479

mRNA Expression by UniProt/SwissProt for VASH1 Gene

Q7L8A9-VASH1_HUMAN
Tissue specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.
genes like me logo Genes that share expression patterns with VASH1: view

Protein tissue co-expression partners for VASH1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VASH1 Gene

Orthologs for VASH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VASH1 35
  • 93.02 (n)
  • 95.59 (a)
VASH1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VASH1 35
  • 94.67 (n)
  • 96.75 (a)
VASH1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vash1 35
  • 88.68 (n)
  • 92.88 (a)
Vash1 16
Vash1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VASH1 35
  • 99.27 (n)
  • 99.18 (a)
VASH1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vash1 35
  • 88.4 (n)
  • 92.6 (a)
oppossum
(Monodelphis domestica)
Mammalia VASH1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VASH1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASH1 35
  • 83.1 (n)
  • 86.62 (a)
VASH1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VASH1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vash1 35
  • 66.99 (n)
  • 72.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100001748 35
  • 72.95 (n)
  • 72.2 (a)
VASH1 36
  • 73 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5764 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for VASH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VASH1 Gene

ENSEMBL:
Gene Tree for VASH1 (if available)
TreeFam:
Gene Tree for VASH1 (if available)

Paralogs for VASH1 Gene

Paralogs for VASH1 Gene

(1) SIMAP similar genes for VASH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VASH1: view

Variants for VASH1 Gene

Sequence variations from dbSNP and Humsavar for VASH1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs973227 -- 76,760,791(+) CCAGC(C/G)GACCC upstream-variant-2KB
rs730548 -- 76,760,378(+) GCTAC(C/G)GGAGC upstream-variant-2KB
rs1861426 -- 76,765,425(+) GTCTG(C/T)ATGAG intron-variant, upstream-variant-2KB
rs1882837 -- 76,775,301(+) TGAGA(A/G)ACTCA intron-variant
rs1882838 -- 76,775,539(+) GGAGG(A/G)CGAGG intron-variant

Variation tolerance for VASH1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VASH1 Gene

HapMap Linkage Disequilibrium report
VASH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VASH1 Gene

Disorders for VASH1 Gene

Relevant External Links for VASH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VASH1

No disorders were found for VASH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASH1 Gene

Publications for VASH1 Gene

  1. Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. (PMID: 16707096) Yamashita H. … Sato Y. (Biochem. Biophys. Res. Commun. 2006) 3 4 23 67
  2. Vasohibin-1 in human breast carcinoma: a potential negative feedback regulator of angiogenesis. (PMID: 19037993) Tamaki K. … Sasano H. (Cancer Sci. 2009) 3 23
  3. Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. (PMID: 19057892) Sato H. … Nishida K. (Diabetologia 2009) 3 23
  4. Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population. (PMID: 19179360) Naito H. … Takakura N. (J. Biochem. 2009) 3 23
  5. Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis. (PMID: 19498005) Hosaka T. … Sato Y. (Am. J. Pathol. 2009) 3 23

Products for VASH1 Gene

Sources for VASH1 Gene

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