 |
 | Services
| |
 |
Aliases & Descriptions for VASH1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA1036 1, 2, 3 | | VASH 3 |
| | | Descriptions |
|---|
| vasohibin 1 2 |
|
| | Search outside databases for aliases for VASH1 gene |
Summaries for VASH1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VASH1_HUMAN, Q7L8A9Function: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activityGene Wiki entry for VASH1 |
Genomic Location for VASH1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VASH1 gene 
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3VASH1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P076299:
(about GC identifiers)
Start:
|
76,298,285 bp from pter |
End:
|
76,319,111 bp from pter |
Size:
|
20,827 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000014.7 NT_026437.11
| Proteins for VASH1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VASH1_HUMAN, Q7L8A9 (See
protein sequence)Recommended Name: Vasohibin-1 Size: 365 amino acids; 40957 Da
Subcellular location: Secreted
Caution: Although probably secreted, it lacks a canonical signal sequence
Sequence caution: Sequence=AAD44361.1; Type=Erroneous gene model prediction;
Secondary accessions: Q96H02 Q9UBF4 Q9Y629Alternative splicing: 2 isoforms: Q7L8A9-1 Q7L8A9-2 Post-translational modifications:
2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form1
REFSEQ proteins: NP_055724.1
ENSEMBL proteins: ENSP00000167106
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VASH1 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VASH1: Assays for VASH1: | Protein
Domains/ Families for VASH1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q7L8A9 UniProtKB/Swiss-Prot: VASH1_HUMAN, Q7L8A9Similarity: Belongs to the vasohibin family | Gene Function for VASH1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014909
Applied Biosystems Silencer® siRNAs for VASH1
Sigma-Aldrich siRNA for VASH1  Sigma-Aldrich shRNA for VASH1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014909                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014909                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014909 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014909
UniProtKB/Swiss-Prot: VASH1_HUMAN, Q7L8A9Function: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activityInduction: By VEGF1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Vash1):
| Pathways & Interactions for VASH1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VASH1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VASH1
|
Transcripts for VASH1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014909
Sigma-Aldrich siRNA for VASH1  Sigma-Aldrich shRNA for VASH1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014909 REFSEQ mRNAs for VASH1 gene: NM_014909.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014909               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014909                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014909                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014909  Additional cDNA sequence: AB028959.1 AF055021.1 AK094330.1 AK291377.1 AL832588.2 BC009031.1 BC051896.1 9 DOTS entries: DT.453848 DT.311953 DT.70100318 DT.108020 DT.65284442 DT.100654054 DT.95241664 DT.100781249 DT.95375355 24/166 AceView cDNA sequences (see all 166
):AI338488 AI990120 BE349025 AF055021 AI694412 BE222175 BU782643 BE674799 BU621127 AA115240 BM675057 BQ233634 AI801580 CA308259 AI873697 BE220471 AW236989 CA448293 BM713191 AK094330 CD626309 BM708077 AW206719 BC051896
highest scoring ESTs for VASH1:AB028959 AA043953 AA043965 AA142893 AA622153 AA704552 AA808078 AA813421 AA887003 AI360738 Unigene Cluster for VASH1: Vasohibin 1 Hs.525479 [show with all ESTs]Unigene Representative Sequence: NM_014909
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000167106
|
Expression for VASH1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VASH1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VASH1
1 / 2 / 3 10 probe-sets matching VASH1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGTGTGCTTG
SOURCE GeneReport for Unigene cluster: Hs.525479
Expression variation in blood from EXPOLDB for VASH1 UniProtKB/Swiss-Prot: VASH1_HUMAN, Q7L8A9Tissue specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions |
Orthologs for VASH1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VASH1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for VASH1
ENSEMBL Gene Tree for VASH1 | Paralogs for VASH1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VASH1 gene
- VASH22
|
SNPs/Variants for VASH1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VASH1 (up to first 250kb)
|
Disorders & Mutations for VASH1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609011
1 Novoseek disease relationship for VASH1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
2 |
15467828 (1) |
About this table
|
Medical News for VASH1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VASH1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for VASH1 gene (see all 24
):- Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. (PubMed id 16707096)1, 3, 4 Yamashita H.... Sato Y. (2006)
- Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells. (PubMed id 15649403)1, 3, 4 Shimizu K.... Sato Y. (2005)
- Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. (PubMed id 15467828)1, 3, 4 Watanabe K.... Sato Y. (2004)
- Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin. (PubMed id 16488400)1, 3, 4 Sonoda H.... Sato Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)3, 4 Heilig R.... Weissenbach J. (2003)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)3, 4 Kikuno R....Ohara O. (1999)
- Vasohibin-1 in human breast carcinoma: a potential negative feedback regulator of angiogenesis. (PubMed id 19037993)1, 3 Tamaki K....Sasano H. (2009)
- Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer. (PubMed id 18325046)1, 3 Yoshinaga K....Sato Y. (2008)
- Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. (PubMed id 19057892)1, 3 Sato H....Nishida K. (2009)
|
Search for VASH1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VASH1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VASH1
(According to HUGE)
About This Section
| |
Specialized Databases showing VASH1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VASH1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VASH1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for VASH1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|