VARS2 Gene
protein-coding GIFtS: 49
GC06P030992
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valyl-tRNA synthetase 2, mitochondrial (putative) (Previous names: valyl-tRNA synthetase 2-like, valyl-tRNA synthetase like ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: VARS2L, VARSL)
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Aliases & Descriptions for VARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| DKFZP434L1435 1 | | EC 6.1.1.9 3 | | Em:AB023048.4 1 | | G7A 5 | | KIAA1885 1, 3 | | MGC138259 2 | | MGC142165 2 | | OTTHUMP00000062434 2 | | VARS 5 | | VARS1 5 | | VARS2L 2, 3 | | VARSL 2, 3 | | ValRS 3 |
| | | Descriptions |
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| Valine--tRNA ligase 3 | | Valyl-tRNA synthetase-like 3 | | valine tRNA ligase 2, mitochondrial (putative) 2 | | valyl-tRNA synthetase 2, mitochondrial 2 | | valyl-tRNA synthetase 2, mitochondrial (putative) 2 | | valyl-tRNA synthetase 2-like 1, 2 | | valyl-tRNA synthetase like 1, 2 |
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| | Search outside databases for aliases for VARS2 genePrevious GC identifers: GC06M031816 GC06M031516 GC06M031851 GC06M031852 GC06M031853 GC06Pc31014 |
Summaries for VARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Location for VARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33VARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P030992:
(about GC identifiers)
Start:
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30,989,961 bp from pter |
End:
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31,002,212 bp from pter |
Size:
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12,252 bases |
Orientation:
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plus strand |
2 alternative locations:
| Chr6+,c6_COX 31,019,107-31,031,210 | Chr6+,c6_QBL 31,014,423-31,026,685 |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113893.1
| Proteins for VARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYVM_HUMAN, Q5ST30 (See
protein sequence)Recommended Name: Valyl-tRNA synthetase, mitochondrial precursor Size: 1063 amino acids; 118462 Da
Subcellular location: Mitochondrion (Potential)
Sequence caution: Sequence=BAD92716.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA; Sequence=CAM24842.1; Type=Erroneous gene model prediction; Sequence=CAM25404.1; Type=Erroneous gene model prediction; Sequence=CAQ06763.1; Type=Erroneous gene model prediction; Sequence=CAQ09774.1; Type=Erroneous gene model prediction; Sequence=CAQ10925.1; Type=Erroneous gene model prediction;
Secondary accessions: A2ABL7 Q2M2A0 Q59FI1 Q5SQ96 Q5SS98 Q6DKJ5 Q6ZV24 Q96GN2 Q96H77 Q96Q02 Q9H6R2 Q9UFH7Alternative splicing: 2 isoforms: Q5ST30-1 Q5ST30-2 REFSEQ proteins: NP_065175.3
ENSEMBL proteins: ENSP00000316092 ENSP00000365483
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VARS2: Assays for VARS2: | Protein
Domains/ Families for VARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5ST30
ProtoNet protein and cluster: Q5ST30 3 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002303 Valyl-tRNA synthetase signature IPB013155 tRNA synthetase
UniProtKB/Swiss-Prot: SYVM_HUMAN, Q5ST30Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for VARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020442
Applied Biosystems Silencer® siRNAs for VARS2
Sigma-Aldrich siRNA for VARS2  Sigma-Aldrich shRNA for VARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020442                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020442                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020442 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020442
UniProtKB/Swiss-Prot: SYVM_HUMAN, Q5ST30Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)Enzyme Number (IUBMB): EC 6.1.1.9 Genatlas biochemistry entry for VARS2:valyl-tRNA synthetase 2,same as G7a,see HTFAG@4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for VARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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3 Interacting proteins for VARS2 (ENSP000003160923) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006438 | valyl-tRNA aminoacylation |
IEA | -- | About this table
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Drugs & Compounds for VARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for VARS2
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Transcripts for VARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020442
Sigma-Aldrich siRNA for VARS2  Sigma-Aldrich shRNA for VARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020442 REFSEQ mRNAs for VARS2 gene: NM_020442.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020442               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020442                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020442                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020442  Additional cDNA sequence: AB067472.1 AK000511.1 AK025618.1 AK026063.1 AK094483.1 AK125069.1 AK293780.1 AK294451.1 AK303415.1 AK304807.1 AK315733.1 AL122037.1 BC008844.2 BC009355.2 BC063427.1 BC073838.1 BC112054.1 BC113605.1 BC143534.1 BC143535.1 BC143536.1 10 DOTS entries: DT.414330 DT.99956622 DT.97848345 DT.101967025 DT.100783857 DT.100783864 DT.100783861 DT.121348680 DT.100783856 DT.95370180 24/149 AceView cDNA sequences (see all 149
):BQ065288 BQ642051 BQ065988 BM827439 BQ057625 BQ059035 BQ063810 BQ641944 BQ065373 BQ063639 Z38986 BQ061568 BQ061525 AA496582 BQ061610 BQ056176 BQ062109 BQ064294 BQ054908 BG910473 BQ055455 AI708217 BX095238 M78120 Unigene Cluster for VARS2: Valyl-tRNA synthetase 2, mitochondrial (putative) Hs.597526 [show with all ESTs]Unigene Representative Sequence: AB067472
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for VARS2 (see all 10
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | |
| SP1: | |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 14b | · | 14c | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VARS2
2 Ensembl transcripts including schematic representations: ENST00000321897
ENST00000376306
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Expression for VARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VARS2
1 / 2 6 probe-sets matching VARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGCTGCAGG
SOURCE GeneReport for Unigene cluster: Hs.597526
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Orthologs for VARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for VARS2 gene from 5/7 species (see all 7
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About this table Species with no ortholog for VARS2
ENSEMBL Gene Tree for VARS2 | Paralogs for VARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VARS2 gene
- VARS2 IARS2 IARS22
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SNPs/Variants for VARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for VARS2 (up to first 250kb)
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Disorders & Mutations for VARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 192150
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Medical News for VARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for VARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for VARS2 gene: |
Search for VARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing VARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
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| Other Databases showing VARS2
(According to HUGE)
About This Section
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Specialized Databases showing VARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Services for VARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for VARS2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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