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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VARS Gene

protein-coding   GIFtS: 63
GCID: GC06M031745

Valyl-TRNA Synthetase

(Previous name: valyl-tRNA synthetase 2)
(Previous symbol: VARS2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Valyl-TRNA Synthetase1 2 3     cytoplasmic1
VARS21 2 3 5     Valine TRNA Ligase 11
G7A2 3 5     valRS2
Valyl-TRNA Synthetase 21 2     Valine TRNA Ligase 1, Cytoplasmic2
Protein G7a2 3     Valine--TRNA Ligase2
EC 6.1.1.93 8     ValRS3
VARS12 5     EC 6.1.18

External Ids:    HGNC: 126511   Entrez Gene: 74072   Ensembl: ENSG000002043947   OMIM: 1921505   UniProtKB: P266403   

Export aliases for VARS gene to outside databases

Previous GC identifers: GC06M031855 GC06M031531


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to
class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility
complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for VARS Gene: 
VARS (valyl-tRNA synthetase) is a protein-coding gene. Diseases associated with VARS include diabetic cataract, and scotoma, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include valine-tRNA ligase activity and aminoacyl-tRNA editing activity. An important paralog of this gene is VARS2.

Gene Wiki entry for VARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167247.1  NC_018917.2  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VARS gene promoter:
         Max1   MyoD   MZF-1   CP2   POU2F1   POU2F1a   STAT3   Zic3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVARS promoter sequence
   Search SABiosciences Chromatin IP Primers for VARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

VARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VARS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031745:  view genomic region     (about GC identifiers)

Start:
31,745,295 bp from pter      End:
31,763,730 bp from pter
Size:
18,436 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 3,030,877-3,049,294      Chr6-,NT_167248 3,053,032-3,057,358      Chr6-,NT_167249 3,076,107-3,093,568     
Chr6-,NT_167247 3,124,992-3,143,409      Chr6-,NT_113891.2 3,254,866-3,273,281      Chr6-,NT_167244 3,060,045-3,078,462     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640 (See protein sequence)
Recommended Name: Valine--tRNA ligase  
Size: 1264 amino acids; 140476 Da
Subunit: Forms high-molecular-mass aggregates with elongation factor 1
Sequence caution: Sequence=CAA41990.1; Type=Frameshift; Positions=620, 640;
Secondary accessions: B0V1N1 Q5JQ90 Q96E77 Q9UQM2

Explore the universe of human proteins at neXtProt for VARS: NX_P26640

Explore proteomics data for VARS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26640

  • 4/28 DME Specific Peptides for VARS (P26640) (see all 28)
     KITPAHD  PPPNVTG  GEKKDVS  WWGHRIP 

    VARS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VARS Protein Expression
    REFSEQ proteins: NP_006286.1  
    ENSEMBL proteins: 
     ENSP00000364815   ENSP00000415679   ENSP00000413925   ENSP00000398317  
    Reactome Protein details: P26640
    Human Recombinant Protein Products for VARS: 
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    Novus Biologicals VARS Proteins
    Novus Biologicals VARS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VARS 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    VARS for ontologies           About GeneDecksing



    VARS Antibody Products: 
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    ThermoFisher Antibody for VARS
    LSBio Antibodies in human, mouse, rat for VARS 

    Assay Products for VARS: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for VARS 
    Cloud-Clone Corp. CLIAs for VARS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5/11 InterPro protein domains (see all 11):
     IPR001412 aa-tRNA-synth_I_CS
     IPR002303 Valyl-tRNA_ligase
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry P26640

    ProtoNet protein and cluster: P26640

    4 Blocks protein domains:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002303 Valyl-tRNA synthetase signature
    IPB004045 Glutathione S-transferase
    IPB013155 tRNA synthetase


    UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 GST C-terminal domain


    VARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYVC_HUMAN, P26640
    Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
    Enzyme regulation: Can be regulated by protein kinase C-dependent phosphorylation

         Enzyme Numbers (IUBMB): EC 6.1.1.91 2 EC 6.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0002161aminoacyl-tRNA editing activity IEA--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004832valine-tRNA ligase activity IDA8428657
    GO:0005515protein binding ----
         
    VARS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VARS:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VARS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VARS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VARS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VARS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VARS:
    hsa-miR-137
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of VARS

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of VARS 

    Cell Line
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    Search LifeMap BioReagents cell lines for VARS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VARS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.54
    Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for VARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for VARS):
        Aminoacyl-tRNA biosynthesis


    VARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VARS

    5/87 Interacting proteins for VARS (P266401, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304801, 3EBI-355765,EBI-1054175 I2D: score=1 I2D: score=1 
    EEF1A2Q056391, 3EBI-355765,EBI-354943 I2D: score=2 
    EEF1DP296922, 3MINT-6699624 I2D: score=2 
    EPB41P111711, 3EBI-355765,EBI-1050906 I2D: score=2 
    IKBKGQ9Y6K92, 3MINT-48127 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation NAS--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006438valyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    VARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VARS (SYVC)

    5 HMDB Compounds for VARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Valine(2S)-2-Amino-3-methylbutanoate (see all 27)72-18-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for VARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Valine(2S)-2-Amino-3-methylbutanoic acid (see all 10)72-18-4target--15710393 17095543
    enzymesubstrate15710393 17095543 15710393 17095543

    9 Novoseek inferred chemical compound relationships for VARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 83.8 1 16843487 (1)
    trna 66 20 9988688 (7), 8611551 (2), 18755686 (1), 10792042 (1) (see all 6)
    valine 55.3 2 8611551 (1), 10995737 (1)
    threonine 43.5 5 19398261 (1), 8611551 (1), 10995737 (1), 10792042 (1)
    isoleucine 38.1 1 10995737 (1)
    gdp 35.6 2 9552369 (1), 9988688 (1)
    gtp 33.9 5 9988688 (4), 9552369 (1)
    cysteine 4.32 1 10792042 (1)
    serine 0.406 1 10995737 (1)

    Search CenterWatch for drugs/clinical trials and news about VARS / SYVC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VARS gene: 
    NM_006295.2  

    Unigene Cluster for VARS:

    Valyl-tRNA synthetase
    Hs.520026  [show with all ESTs]
    Unigene Representative Sequence: NM_006295
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470953 ENST00000375663(uc021yuy.1 uc003nxe.3 uc011doi.1)
    ENST00000463184 ENST00000428445 ENST00000482996 ENST00000479051 ENST00000459667
    ENST00000461874 ENST00000474643 ENST00000483275 ENST00000461328 ENST00000495010
    ENST00000489979 ENST00000440048 ENST00000444930
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VARS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VARS:
    hsa-miR-137
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VARS

    Additional mRNA sequence: 

    AK300033.1 AK302762.1 BC012808.2 M98326.1 X59303.1 

    22 DOTS entries:

    DT.449684  DT.100823403  DT.95374587  DT.92455549  DT.92455552  DT.102841790  DT.121376447  DT.40119869 
    DT.102841785  DT.95374585  DT.95374590  DT.121376451  DT.85104293  DT.92056916  DT.95374580  DT.100031397 
    DT.100765773  DT.100835569  DT.92455556  DT.95374581  DT.95374582  DT.95374588 

    24/428 AceView cDNA sequences (see all 428):

    BQ052263 AI066531 AI143739 N58231 BQ070191 BQ684457 BM682072 BQ019799 
    AI202024 CA424415 CA423494 BM727305 BM791869 BE671946 BM799190 BQ053676 
    BU629728 AW243030 BQ064853 BU845603 BM832363 AI498133 AL047167 BM713306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VARS expression in normal human tissues (normalized intensities)      VARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATGGCAG
    VARS Expression
    About this image


    VARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See VARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VARS

    SOURCE GeneReport for Unigene cluster: Hs.520026
        SABiosciences Custom PCR Arrays for VARS
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VARS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VARS gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vars1 , 5 valyl-tRNA synthetase1, 5 87.78(n)1
    93.51(a)1
      17 (18.54 cM)5
    223211  NM_011690.31  NP_035820.31 
     350009875 
    lizard
    (Anolis carolinensis)
    Reptilia --
    VARS6
    Uncharacterized protein
    70(a)
    62(a)
    many → 1
    many → 1
    GL343570.1(61361-95700)
    AAWZ02036383(4725-11732)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985866.12   -- 74.04(n)    CA985866.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vars22 valyl-tRNA synthetase 2 76.36(n)   114427  AF506220.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-val1 Valyl-tRNA synthetase 61.44(n)
    61.05(a)
      45783  NM_165970.1  NP_725259.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vars-21 Protein VARS-2 55.51(n)
    54.44(a)
      173224  NM_060976.3  NP_493377.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VAS11 Vas1p 52.68(n)
    50.49(a)
      852986   NP_011608.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TWN21 Valyl-tRNA synthetase 53.58(n)
    49.35(a)
      838023  NM_101328.3  NP_172913.1 
    rice
    (Oryza sativa)
    Liliopsida AK121157.12   -- 71.53(n)    AK121157.1 


    ENSEMBL Gene Tree for VARS (if available)
    TreeFam Gene Tree for VARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VARS gene
    VARS22  
    2 SIMAP similar genes for VARS using alignment to 7 protein entries:     SYVC_HUMAN (see all proteins):
    VARS2    EEF1G

    VARS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/488 SNPs in VARS are shown (see all 488)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407568431,2
    --31531200(+) CACGCC/TCCCCT 1 -- int10--------
    rs344426391,2
    C--31661859(+) CTCCT-/GGGCAG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1497684631,2
    C--31661877(+) CCGGGC/TTTGAC 1 -- int10--------
    rs1130408351,2
    --31662028(+) CAGGGC/AGGGCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs94617251,2
    C,F,H--31662041(+) CCTTGG/CCTGCA 1 -- int15Minor allele frequency- C:0.00NS EA NA 418
    rs1485374781,2
    C--31662132(+) CCAGAA/TAGACG 1 -- int10--------
    rs1428488631,2
    --31662137(+) TAGACA/GCACCC 1 -- int10--------
    rs1884901541,2
    --31662138(+) AGACGC/TACCCC 1 -- int10--------
    rs27364261,2
    C,F,A,H--31662239(-) TTGTCA/GTCTGT 1 -- int129Minor allele frequency- G:0.35NS EA NA WA CSA 3055
    rs2004180271,2
    --31662368(+) ACCTTC/TCTGAG 2 R syn10--------

    HapMap Linkage Disequilibrium report for VARS (31745295 - 31763730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for VARS (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6583n71CNV Loss21882294
    nsv884434CNV Loss21882294
    dgv6587n71CNV Loss21882294
    nsv884442CNV Loss21882294
    dgv6585n71CNV Loss21882294
    dgv6582n71CNV Loss21882294
    nsv884438CNV Loss21882294
    dgv6586n71CNV Loss21882294
    nsv884441CNV Loss21882294
    dgv6584n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192150    OMIM disorders: --

    11 diseases for VARS:    About MalaCards
    diabetic cataract    scotoma    cataract    cleft palate
    macular degeneration    pneumonia    systemic lupus erythematosus    ataxia
    lupus erythematosus    obesity    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for VARS:
    Scotoma

    VARS for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for VARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cleft palate 36.9 1 7993390 (1)
    shock 9.56 2 9461376 (1)

    Genetic Association Database (GAD): VARS
    Human Genome Epidemiology (HuGE) Navigator: VARS (5 documents)

    Export disorders for VARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VARS gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with VARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase. (PubMed id 1898367)1, 2, 9 Hsieh H.-L. and Campbell R.D. (1991)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 3 Bonnefond L....Sissler M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase. (PubMed id 8428657)1, 2 Vilalta A.... Yang D.C.H. (1993)
    9. Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. (PubMed id 8294461)1, 9 Bec G....Waller J.P. (1994)
    10. Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences. (PubMed id 8666263)1, 9 Motorin Y. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7407 HGNC: 12651 AceView: VARS2 Ensembl:ENSG00000204394 euGenes: HUgn7407
    ECgene: VARS Kegg: 7407 H-InvDB: VARS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VARS gene:
    Search GeneIP for patents involving VARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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