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Aliases & Descriptions for VARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.9 3 | | G7A 2, 3, 5 | | VARS1 2, 5 | | VARS2 2, 3, 5 | | ValRS 3 |
| | | Descriptions |
|---|
| Protein G7a 3 | | Valine--tRNA ligase 3 | | valine tRNA ligase 1, cytoplasmic 2 | | valyl-tRNA synthetase 2 | | valyl-tRNA synthetase 2 1, 2 |
|
| | Search outside databases for aliases for VARS gene |
Summaries for VARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq] Gene Wiki entry for VARS |
Genomic Location for VARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VARS gene 
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3VARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031855:
(about GC identifiers)
Start:
|
31,853,274 bp from pter |
End:
|
31,871,691 bp from pter |
Size:
|
18,418 bases |
Orientation:
|
minus strand |
2 alternative locations:
| Chr6-,c6_QBL 31,892,485-31,896,832 | Chr6-,c6_COX 31,879,916-31,898,349 |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113895.1
| Proteins for VARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640 (See
protein sequence)Recommended Name: Valyl-tRNA synthetase Size: 1264 amino acids; 140476 Da
Subunit: Forms high-molecular-mass aggregates with elongation factor 1
Sequence caution: Sequence=CAA41990.1; Type=Frameshift; Positions=620, 640;
Secondary accessions: Q5JQ90 Q96E77 Q9UQM2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006286.1
ENSEMBL proteins: ENSP00000364815
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VARS: Assays for VARS: | Protein
Domains/ Families for VARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P26640
ProtoNet protein and cluster: P26640 4 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002303 Valyl-tRNA synthetase signature IPB004045 Glutathione S-transferase IPB013155 tRNA synthetase
UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640Similarity: Belongs to the class-I aminoacyl-tRNA synthetase familySimilarity: Contains 1 GST C-terminal domain | Gene Function for VARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006295
Applied Biosystems Silencer® siRNAs for VARS
Sigma-Aldrich siRNA for VARS  Sigma-Aldrich shRNA for VARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006295                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006295                                  untagged cDNA clone in CMV expression vector: NM_006295 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006295
UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)Enzyme regulation: Can be regulated by protein kinase C-dependent phosphorylationEnzyme Number (IUBMB): EC 6.1.1.9 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for VARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for VARS (Your Favorite Gene powered by Ingenuity) 
5/21 Interacting proteins for VARS (P266401, 2 ENSP000003648153) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VARS 6 Novoseek chemical compound relationships for VARS gene
About this table
|
Transcripts for VARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006295
Sigma-Aldrich siRNA for VARS  Sigma-Aldrich shRNA for VARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006295 REFSEQ mRNAs for VARS gene: NM_006295.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006295               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006295                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006295                                  untagged cDNA clone in CMV expression vector: NM_006295  Additional cDNA sequence: AK300033.1 AK302762.1 BC012808.2 CR612648.1 CR615665.1 CR622653.1 M98326.1 X59303.1 22 DOTS entries: DT.449684 DT.100823403 DT.95374587 DT.92455549 DT.92455552 DT.102841790 DT.121376447 DT.40119869 DT.102841785 DT.95374585 DT.95374590 DT.121376451 DT.85104293 DT.92056916 DT.95374580 DT.100031397 DT.100835569 DT.92455556 DT.95374581 DT.95374582 DT.95374588 DT.100765773 24/428 AceView cDNA sequences (see all 428
):AI066531 BE296688 BQ056524 BQ064853 BQ931831 AW137556 BM831842 BU845226 CF126441 BQ220899 BU857198 CR615665 CA424415 BQ068225 AI361346 BU155906 CF131664 BQ218577 BM550938 BE396932 AI498133 BQ061845 BM729145 BM831206
highest scoring ESTs for VARS:X59303 AL514402 BE242709 BE242737 BG037211 BM473655 BM560598 BM908229 BQ423267 BU154624 Unigene Cluster for VARS: Valyl-tRNA synthetase Hs.520026 [show with all ESTs]Unigene Representative Sequence: NM_006295
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000375663
|
Expression for VARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VARS
1 / 2 / 3 5 probe-sets matching VARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGATGGCAG
SOURCE GeneReport for Unigene cluster: Hs.520026
Expression variation in blood from EXPOLDB for VARS |
Orthologs for VARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VARS gene from 5/23 species (see all 23
)
About this table Species with no ortholog for VARS
ENSEMBL Gene Tree for VARS | Paralogs for VARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VARS gene
- IARS2 IARS22 VARS22
|
SNPs/Variants for VARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VARS (up to first 250kb)
|
Disorders & Mutations for VARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 192150
2 Novoseek disease relationships for VARS gene
About this table
|
Medical News for VARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/44 PubMed articles for VARS gene (see all 44
):- Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase. (PubMed id 1898367)1, 3, 4 Hsieh H.-L. and Campbell R.D. (1991)
- Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)2, 3 Bonnefond L....Sissler M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)3, 4 Xie T.... Hood L. (2003)
- Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase. (PubMed id 8428657)3, 4 Vilalta A.... Yang D.C.H. (1993)
- Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. (PubMed id 8294461)1, 3 Bec G....Waller J.P. (1994)
- Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences. (PubMed id 8666263)1, 3 Motorin Y. (1996)
- Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit. (PubMed id 16229838)1, 3 Jiang S....Norcum M.T. (2005)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
|
Search for VARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VARS:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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