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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VARS Gene

protein-coding   GIFtS: 61
GCID: GC06M031745

valyl-tRNA synthetase

(Previous name: valyl-tRNA synthetase 2 )
(Previous symbol: VARS2)
 Explore 12 diseases affiliated with
VARS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VARS    

Aliases
for VARS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Valyl-TRNA Synthetase1 2 3     VARS12 5
VARS21 2 3 5     ValRS3
G7A2 3 5     Valine TRNA Ligase 1, Cytoplasmic2
Valyl-TRNA Synthetase 21 2     Valine--TRNA Ligase2
Protein G7a2 3     ValRS3
EC 6.1.1.93 8     EC 6.1.18

External Ids:    HGNC: 126511   Entrez Gene: 74072   Ensembl: ENSG000002043947   OMIM: 1921505   UniProtKB: P266403   

Export aliases for VARS gene to outside databases

Previous GC identifers: GC06M031855 GC06M031531


Summaries
for VARS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VARS:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central
role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be
among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I
aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.
(provided by RefSeq, Jul 2008)

Gene Wiki entry for VARS


Genomic Views
for VARS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VARS gene promoter:
         Max1   MyoD   MZF-1   CP2   POU2F1   POU2F1a   STAT3   Zic3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VARS promoter sequence
   Search SABiosciences Chromatin IP Primers for VARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

VARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VARS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031745:  view genomic region     (about GC identifiers)

Start:
 31,745,295 bp from pter      End:
 31,763,730 bp from pter
Size:
 18,436 bases      Orientation:
 minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_5 31,736,415-31,754,832      Chr6-,ALT_REF_LOCI_6 31,749,636-31,789,542      Chr6-,ALT_REF_LOCI_3 31,727,480-31,756,935     
Chr6-,ALT_REF_LOCI_2 31,732,662-31,790,265      Chr6-,ALT_REF_LOCI_1 31,756,648-31,783,365      Chr6-,ALT_REF_LOCI_7 31,665,572-31,683,033     

Proteins
for VARS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640 (See protein sequence)
Recommended Name: Valine--tRNA ligase  
Size: 1264 amino acids; 140476 Da
Subunit: Forms high-molecular-mass aggregates with elongation factor 1
Sequence caution: Sequence=CAA41990.1; Type=Frameshift; Positions=620, 640;
Secondary accessions: B0V1N1 Q5JQ90 Q96E77 Q9UQM2

Explore the universe of human proteins at neXtProt for VARS: NX_P26640

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26640

    • 4/28 DME Specific Peptides for VARS (P26640) (see all 28)
     KITPAHD  PPPNVTG  GEKKDVS  WWGHRIP 

    VARS Protein expression data from MOPED and PaxDb:    About this image 
    VARS Protein Expression
    REFSEQ proteins: NP_006286.1  
    ENSEMBL proteins: 
     ENSP00000364815   ENSP00000415679   ENSP00000413925   ENSP00000398317  
    Reactome Protein details: P26640
    Human Recombinant Protein Products for VARS: 
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    Novus Biologicals VARS Proteins
    Novus Biologicals VARS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VARS

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    VARS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for VARS

    Protein Domains /
    Families
    for VARS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VARS for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR001412 aa-tRNA-synth_I_CS
     IPR002303 Valyl-tRNA_ligase
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry P26640

    ProtoNet protein and cluster: P26640

    4 Blocks protein families:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002303 Valyl-tRNA synthetase signature
    IPB004045 Glutathione S-transferase
    IPB013155 tRNA synthetase


    UniProtKB/Swiss-Prot: SYVC_HUMAN, P26640
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 GST C-terminal domain


    Function
    for VARS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYVC_HUMAN, P26640
    Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
    Enzyme regulation: Can be regulated by protein kinase C-dependent phosphorylation

         Enzyme Numbers (IUBMB): EC 6.1.1.91 2 EC 6.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002161aminoacyl-tRNA editing activity IEA--
    GO:0004832valine-tRNA ligase activity IDA8428657
    GO:0005524ATP binding IEA--
         
    VARS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VARS:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VARS 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: VARS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VARS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VARS:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VARS (see all 7)
    OriGene shRNA RFP: VARS
    OriGene siRNA: VARS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VARS
    Sirion Biotech Custom design and validation of potent shRNA sequences against VARS 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VARS
    Sirion Biotech Customized adenovirus for overexpression of VARS 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VARS


    Pathways & Interactions
    for VARS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Aminoacyl-tRNA biosynthesis0.54
    		Cytosolic tRNA aminoacylation0.57
    2Valine, leucine and isoleucine biosynthesis
    		Valine, leucine and isoleucine biosynthesis1.00
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for VARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    2         Kegg Pathways  (Kegg details for VARS):
        Valine, leucine and isoleucine biosynthesis
    Aminoacyl-tRNA biosynthesis


    VARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VARS

    5/87 Interacting proteins for VARS (P266401, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304801, 3EBI-355765,EBI-1054175 I2D: score=1 I2D: score=1 
    EEF1A2Q056391, 3EBI-355765,EBI-354943 I2D: score=2 
    EEF1DP296922, 3MINT-6699624 I2D: score=2 
    EPB41P111711, 3EBI-355765,EBI-1050906 I2D: score=2 
    IKBKGQ9Y6K92, 3MINT-48127 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation NAS--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006438valyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    VARS for ontologies           About GeneDecksing



    Drugs & Compounds
    for VARS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VARS

    5 HMDB Compounds for VARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Valine(2S)-2-Amino-3-methylbutanoate (see all 27)72-18-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for VARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Valine(2S)-2-Amino-3-methylbutanoic acid (see all 10)72-18-4target--15710393 17095543
    enzymesubstrate15710393 17095543 15710393 17095543

    9 Novoseek chemical compound relationships for VARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 83.8 1 16843487 (1)
    trna 66 20 9988688 (7), 8611551 (2), 18755686 (1), 10792042 (1) (see all 6)
    valine 55.3 2 8611551 (1), 10995737 (1)
    threonine 43.5 5 19398261 (1), 8611551 (1), 10995737 (1), 10792042 (1)
    isoleucine 38.1 1 10995737 (1)
    gdp 35.6 2 9552369 (1), 9988688 (1)
    gtp 33.9 5 9988688 (4), 9552369 (1)
    cysteine 4.32 1 10792042 (1)
    serine 0.406 1 10995737 (1)

    Search CenterWatch for drugs/clinical trials and news about VARS / SYVC 

    Transcripts
    for VARS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VARS gene: 
    NM_006295.2  

    Unigene Cluster for VARS:

    Valyl-tRNA synthetase
    Hs.520026  [show with all ESTs]
    Unigene Representative Sequence: NM_006295
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470953 ENST00000375663(uc021yuy.1 uc003nxe.3 uc011doi.1)
    ENST00000463184 ENST00000428445 ENST00000482996 ENST00000479051 ENST00000459667
    ENST00000461874 ENST00000474643 ENST00000483275 ENST00000461328 ENST00000495010
    ENST00000489979 ENST00000440048 ENST00000444930

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VARS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VARS:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VARS (see all 7)
    OriGene shRNA RFP: VARS
    OriGene siRNA: VARS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VARS
    Sirion Biotech Custom design and validation of potent shRNA sequences against VARS 
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK300033.1 AK302762.1 BC012808.2 M98326.1 X59303.1 

    22 DOTS entries:

    DT.449684  DT.100823403  DT.95374587  DT.92455549  DT.92455552  DT.102841790  DT.121376447  DT.40119869 
    DT.102841785  DT.95374585  DT.95374590  DT.121376451  DT.85104293  DT.92056916  DT.95374580  DT.100031397 
    DT.100765773  DT.100835569  DT.92455556  DT.95374581  DT.95374582  DT.95374588 

    24/428 AceView cDNA sequences (see all 428):

    BM729145 AI741496 BM713306 CB125660 BQ068470 AI066531 BQ056454 AI632783 
    BU191327 AI674795 BU849178 BM800696 AW205398 BQ073191 BQ641950 BQ958912 
    CR622653 BQ218577 BM681683 BE791212 BQ684457 BU857198 BQ019799 BQ688775 

    GeneLoc Exon Structure


    Expression
    for VARS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGATGGCAG
    VARS Expression
    About this image

    VARS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VARS

    SOURCE GeneReport for Unigene cluster: Hs.520026
        SABiosciences Custom PCR Arrays for VARS
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VARS

    Orthologs
    for VARS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for VARS gene from 8/40 species (see all 40)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA985866.12   -- 74.04(n)    CA985866.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii vars22 valyl-tRNA synthetase 2 76.36(n)   114427  AF506220.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aats-val1 Valyl-tRNA synthetase 61.44(n)
    61.05(a)    		   45783  NM_165970.1  NP_725259.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea vars-21 Protein VARS-2 55.51(n)
    54.44(a)    		   173224  NM_060976.3  NP_493377.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes VAS11 Vas1p 52.68(n)
    50.49(a)    		   852986   NP_011608.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TWN21 Valyl-tRNA synthetase 53.58(n)
    49.35(a)    		   838023  NM_101328.3  NP_172913.1 
    rice
    (Oryza sativa)    		 Liliopsida AK121157.12   -- 71.53(n)    AK121157.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria valS6
    		 valyl-tRNA synthetase
    		 39(a)
    		 possible ortholog
    		 Chromosome(4479005-4481860)


    ENSEMBL Gene Tree for VARS (if available)
    TreeFam Gene Tree for VARS (if available) 

    Paralogs
    for VARS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VARS gene
    VARS22  
    2 SIMAP similar genes for VARS using alignment to 10 protein entries:     SYVC_HUMAN (see all proteins):
    VARS2    EEF1G

    VARS for paralogs           About GeneDecksing



    Genomic Variants
    for VARS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/356 NCBI SNPs in VARS are shown (see all 356)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1130408351,2
    		--31531478(+) CAGGGC/AGGGCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs94617251,2
    		C,F,H--31531491(+) CCTTGG/CCTGCA 1 -- int15Minor allele frequency- C:0.00NS EA NA 418
    rs31304911,2
    		C,F--31531869(+) TGGGTG/AAGGAC 1 -- int12Minor allele frequency- A:0.09NA EU 433
    rs734002681,2
    		C--31532053(+) CCACCG/AAGTGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs345857961,2
    		C--31532247(+) TCTAGC/TTCTTG 1 -- int13Minor allele frequency- T:0.03NA EA 124
    rs1116829771,2
    		C--31533148(+) ACACAG/CCTTGG 1 -- spd11Minor allele frequency- C:0.00CSA 1
    rs341201001,2
    		C,F,H--31533292(+) GTCCAC/TCAGCC 2 M V mis13Minor allele frequency- T:0.01NA NS 422
    rs115406371,2
    		C--31533639(-) GCGGGC/TCGACT 2 A V mis11Minor allele frequency- T:0.00NA 2
    rs50307981,2
    		C,F--31533915(-) TGGACG/ATTGGC 2 /I /V mis12Minor allele frequency- A:0.00NA EU 5631
    rs9417151,2
    		C--31534135(+) TGCTGC/GCCACC 1 -- int11Minor allele frequency- G:0.00MN 184

    HapMap Linkage Disequilibrium report for VARS (31745295 - 31763730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VARS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VARS
    DNA2.0 Custom Variant and Variant Library Synthesis for VARS

    Disorders / Diseases
    for VARS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VARS for disorders           About GeneDecksing

    OMIM gene information: 192150    OMIM disorders: --

    12 diseases for VARS:    About MalaCards
    scotoma    systemic lupus erythematosus    lupus erythematosus    macular degeneration
    diabetic cataract    cataract    ataxia    obesity
    pneumonia    tuberculosis    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for VARS:
    Scotoma

    2 Novoseek disease relationships for VARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cleft palate 36.9 1 7993390 (1)
    shock 9.56 2 9461376 (1)

    Human Genome Epidemiology (HuGE) Navigator: VARS (5 documents)

    Export disorders for VARS gene to outside databases

    Publications
    for VARS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VARS gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with VARS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase. (PubMed id 1898367)1, 2, 9 Hsieh H.-L. and Campbell R.D. (1991)
    2. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 3 Bonnefond L....Sissler M. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase. (PubMed id 8428657)1, 2 Vilalta A.... Yang D.C.H. (1993)
    7. Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. (PubMed id 8294461)1, 9 Bec G....Waller J.P. (1994)
    8. Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences. (PubMed id 8666263)1, 9 Motorin Y. (1996)
    9. Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit. (PubMed id 16229838)1, 9 Jiang S....Norcum M.T. (2005)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for VARS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VARS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7407 HGNC: 12651 AceView: VARS2 Ensembl:ENSG00000204394 euGenes: HUgn7407
    ECgene: VARS Kegg: 7407 H-InvDB: VARS

    Other Databases showing VARS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VARS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VARS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VARS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VARS gene:
    Search GeneIP for patents involving VARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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