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VAPB Gene

protein-coding GIFtS: 65

GC20P056397

VAMP (vesicle-associated membrane protein)-associated protein B and C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALS8 ^¹, ², ⁵
OTTHUMP00000031393 ^²
VAMP-B ^²
VAMP-B/VAMP-C ^³
VAMP-C ^²
VAP-B ^¹, ²
VAP-B/VAP-C ^³
VAP-C ^¹, ²
VAPC ^⁵

Descriptions
VAMP (vesicle-associated membrane protein)-associated protein B and C ^²
VAMP-associated 33 kDa protein ^²
VAMP-associated protein B ^²
VAMP-associated protein B/C ^², ³
VAMP-associated protein C ^²

External Ids
HGNC: 12649¹
Entrez Gene: 9217²
UniProtKB: O95292³
Ensembl: ENSG00000124164⁷

Search outside databases for aliases for VAPB gene

Previous GC identifers: GC20P056692 GC20P057602 GC20P057649

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VAPB:

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular

vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA.

This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

[provided by RefSeq]

UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292

Function: May play a role in vesicle trafficking

Gene Wiki entry for VAPB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VAPB gene

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13

VAPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P056397: (about GC identifiers)

Start:	56,397,651 bp from pter
End:	56,455,369 bp from pter
Size:	57,719 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292 (See protein sequence)

Recommended Name: Vesicle-associated membrane protein-associated protein B/C

Size: 243 amino acids; 27228 Da

Subunit: Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts with HCV

NS5A and NS5B

Subcellular location: Cell membrane; Single-pass type IV membrane protein (By similarity).

Endomembrane system; Single-pass type IV membrane protein (By similarity). Note=Present in the

plasma membrane and in intracellular vesicles (By similarity)

Secondary accessions: A2A2F2 O95293 Q9P0H0

Alternative splicing: 2 isoforms: O95292-1 O95292-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004729.1

ENSEMBL proteins:

ENSP00000265619 ENSP00000342443 ENSP00000379147

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VAPB)
	Human Recombinant Proteins from Abnova (VAPB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	15372378 16891305
GO:0005789	endoplasmic reticulum membrane	IDA	16227268
GO:0005794	Golgi apparatus	IDA	16227268
GO:0005886	plasma membrane	IEA	--
GO:0012505	endomembrane system	IEA	--

About this table

Antibodies for VAPB:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of VAPB
	Sigma-Aldrich Antibodies for VAPB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (VAPB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VAPB)
	Novus Biologicals Antibodies for VAPB

Assays for VAPB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95292

ProtoNet protein and cluster: O95292

1 Blocks protein family: IPB000535 Major sperm protein (MSP) domain

UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292

Similarity: Contains 1 MSP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAPB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004738

Applied Biosystems Silencer® siRNAs for VAPB

Sigma-Aldrich siRNA and siRNA Panels for VAPB

Sigma-Aldrich shRNA for VAPB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VAPB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004738
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004738
untagged cDNA clone in CMV expression vector: NM_004738

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004738

UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292

Function: May play a role in vesicle trafficking

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0019899	enzyme binding	IPI	17540579
GO:0042803	protein homodimerization activity	IPI	9920726 16227268 17540579
GO:0046982	protein heterodimerization activity	IPI	9920726 16227268
GO:0048487	beta-tubulin binding	IDA	17540579

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for VAPB

5/13 Interacting proteins for VAPB (O95292¹ ENSP00000265619³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
Epha4 Epha4 (xeno)	Q03137¹	EBI-1188298, EBI-1539152
LEPREL2	ENSP00000290510³	STRING (score=.881)
SOD1	ENSP00000270142³	STRING (score=.818)
SETX	ENSP00000224140³	STRING (score=.795)
VAMP1	ENSP00000355122³	STRING (score=.773)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019048	virus-host interaction	IDA	16227268
GO:0030968	endoplasmic reticulum unfolded protein response	IMP	16891305
GO:0044419	interspecies interaction between organisms	IEA	--
GO:0045070	positive regulation of viral genome replication	IMP	16227268

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VAPB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAPB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004738

Sigma-Aldrich siRNA and siRNA Panels for VAPB

Sigma-Aldrich shRNA for VAPB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004738

REFSEQ mRNAs for VAPB gene:

NM_004738.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004738

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004738
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004738
                                 untagged cDNA clone in CMV expression vector: NM_004738

Additional cDNA sequence:

AB209665.1 AF086628.1 AF086629.1 AF160212.1 AK023241.1 AK024771.1 AK025720.1 AK123538.1

AK127252.1 AK298036.1 AL833440.1 AY358464.1 BC001712.1 BT009811.1

15 DOTS entries:

DT.415728 DT.95114920 DT.101983849 DT.117764 DT.100822371 DT.40310052 DT.95233172 DT.100037682

DT.120810001 DT.91747064 DT.120810003 DT.40316511 DT.95233145 DT.99949548 DT.120810019

24/332 AceView cDNA sequences (see all 332 ):

BQ920266 NM_004738 BQ670067 CD679272 BU543256 AI627354 CF139811 AL120403

BU857571 BE313812 BU177162 AI457553 AI004933 BM741387 BQ071170 BM773403

AK127252 BM770462 AU131215 CA393713 CF129155 BU152663 BQ960966 BQ879996

highest scoring ESTs for VAPB:

AI627354 AA031968 AA032059 AA088270 AA088378 AA148401 AA148402 AA188609 AA188694 AA223608

Unigene Cluster for VAPB:

VAMP (vesicle-associated membrane protein)-associated protein B and C

Hs.182625 [show with all ESTs]

Unigene Representative Sequence: NM_004738

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAPB (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9
SP1:									-				-		-
SP2:													-		-		-
SP3:
SP4:									-				-		-		-
SP5:									-				-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for VAPB

3 Ensembl transcripts including schematic representations:

ENST00000265619 ENST00000341195 ENST00000395802

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VAPB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VAPB

¹ / ² / ³

6 probe-sets matching VAPB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41757_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	W25933	0.60	1.00	0.82	1
40940_at²^{, 3}	U95-A	2	1.00	0.97	0.41	0.20	AI627354	1.00	1.00	1.00	1
202550_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004738	0.60	1.00	0.82	1
202549_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK025720	0.80	1.00	0.91	1
202550_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202549_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VAPB for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGGGAGTG

SOURCE GeneReport for Unigene cluster: Hs.182625
Expression variation in blood from EXPOLDB for VAPB
UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292
Tissue specificity: Ubiquitous. Isoform 1 predominates

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VAPB gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAPB¹	--	VAMP (vesicle-associated membrane protein)-associated more	92.59(n) 96.3(a)	477274 XM_534466.2 XP_534466.2
chimpanzee (Pan troglodytes)	VAPB¹	--	VAMP (vesicle-associated membrane protein)-associated more	99.86(n) 100(a)	469984 XM_001135464.1 XP_001135464.1
cow (Bos taurus)	VAPB¹	--	VAMP (vesicle-associated membrane protein)-associated more	91.5(n) 95.88(a)	326580 XM_581024.3 XP_581024.3
rat (Rattus norvegicus)	Vapb¹	--	VAMP (vesicle-associated membrane protein)-associated more	85.46(n) 88.48(a)	60431 NM_021847.2 NP_068619.1
mouse (Mus musculus)	Vapb^{1, 5}	2 (103.00 cM)⁵	vesicle-associated membrane protein, associated protein more^{1, 5}	87.52(n)¹ 90.12(a)¹	56491¹ NM_019806.5¹ NP_062780.2¹ AA000870⁵ AF115504⁵ (see all 34)

About this table Species with no ortholog for VAPB

ENSEMBL Gene Tree for VAPB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VAPB gene

VAPA²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/399 NCBI SNPs in VAPB are shown (see all 399 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11907021^1,2	A,C,F,H	56396107(+)	`AGGATT/CTGCAC`	1	--	ng5¹		8		EU EA WA	834
	rs6100045^1,2	A,C,F,H	56396151(+)	`TTTACC/TTCAGG`	1	--	ng5¹ tfbs³		12		EU EA WA	1256
	rs6100044^1,2	A,C,F,H	56396117(+)	`CCAACG/AAAGCT`	1	--	ng5¹		4		EU EA WA	418
	rs1059794^1,2	C,F,H,O	56453634(+)	`ATAGGG/CAGGGA`	1	--	ut3¹ ese³ trp³		11		MN NA EU EA WA	1012
	rs7400^1,2	C,F,H	56453962(-)	`ATAGTC/GAAACA`	1	--	ut3¹		13		NS EU EA WA	946
	rs1802459^1,2	C,F,H	56453979(+)	`TCTTGA/GAAAGA`	1	--	ut3¹ ese³ trp³		8		EU EA WA	836
	rs6070466^1,2	F,H	56453450(+)	`TGTCAC/GAAGAG`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs4811990^1,2	A,C	56395921(+)	`tacacC/Gggagt`	1	--	ng5¹		0	--	--	--	--
	rs7344209^1,2	H	56396881(+)	`TTAAAC/GGGTAA`	1	--	ng5¹		3		EU EA	298
	rs3746398^1,2	F	56453581(-)	`GCTCTT/CCTCCA`	1	--	ut3¹ ese³		1		EA	1492

About this table

HapMap Linkage Disequilibrium images for VAPB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605704 disorders: 608627 182980

UniProtKB/Swiss-Prot: VAPB_HUMAN, O95292

Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8) [MIM:608627].

ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting

upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent.

Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely

to be multifactorial, involving both genetic and environmental factors. The disease is inherited

in 5-10% of cases leading to familial forms

Defects in VAPB are a cause of spinal muscular atrophy autosomal dominant Finkel type

(SMAF) [MIM:182980]; also called late-onset spinal muscular atrophy Finkel type or spinal muscular

atrophy proximal adult autosomal dominant. Spinal muscular atrophy refers to a group of

neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal

cord, leading to symmetrical muscle weakness and atrophy. SMAF is characterized by proximal muscle

weakness that begins in the lower limbs and then progresses to upper limbs, onset in late

adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to

40 years after clinical onset

1 Novoseek disease relationship for VAPB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amyotrophic lateral sclerosis	76.72	4	18555774 (2), 17947296 (1), 16729899 (1)

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GeneTests: VAPB

Amyotrophic Lateral Sclerosis

Human Gene Mutation Database: VAPB
Human Genome Epidemiology Navigator: VAPB (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/36 PubMed articles for VAPB gene (see all 36 ):

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. (PubMed id 9920726)^{2, 3, 4} Nishimura Y.... Tanaka T. (1999)
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. (PubMed id 15372378)^{1, 3, 4} Nishimura A.L.... Zatz M. (2004)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. (PubMed id 16227268)^{3, 4} Hamamoto I....Matsuura Y. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{3, 4} Hu R.-M.... Chen J.-L. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9217	HGNC: 12649	AceView: VAPB	Ensembl:ENSG00000124164	euGenes: HUgn9217
ECgene: VAPB	H-InvDB: VAPB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Alsod	http://alsod.iop.kcl.ac.uk/Als/
GeneReviews	http://www.genetests.org/query?gene=VAPB

Licensable Technologies for VAPB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VAPB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VAPB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VAPB		Antibodies for VAPB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VAPB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VAPB)
	Antibodies (VAPB)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (VAPB)
	Antibodies (VAPB)

Search OriGene for VAPB

Search Tocris compounds for VAPB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VAPB

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VAPB Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for VAPB

Summaries
for VAPB

Genomic Location
for VAPB

Proteins
for VAPB

Protein Domains/
Families
for VAPB

Gene Function
for VAPB

Pathways & Interactions
for VAPB

Drugs & Compounds
for VAPB

Transcripts
for VAPB

Expression
for VAPB

Orthologs
for VAPB

Paralogs
for VAPB

SNPs/Variants
for VAPB

Disorders & Mutations
for VAPB

Medical News
for VAPB

Publications
for VAPB

Search for VAPB

Genome Databases showing VAPB

Other Databases showing VAPB

Specialized Databases showing VAPB

Licensable Technologies
for VAPB

Services
for VAPB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VAPB Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor VAPB

Summariesfor VAPB

Genomic Locationfor VAPB

Proteinsfor VAPB

Protein Domains/Familiesfor VAPB

Gene Functionfor VAPB

Pathways & Interactionsfor VAPB

Drugs & Compoundsfor VAPB

Transcriptsfor VAPB

Expression for VAPB

Orthologsfor VAPB

Paralogsfor VAPB

SNPs/Variantsfor VAPB

Disorders & Mutationsfor VAPB

Medical Newsfor VAPB

Publicationsfor VAPB

Search for VAPB

Genome Databases showing VAPB

Other Databases showing VAPB

Specialized Databases showing VAPB

Licensable Technologiesfor VAPB

Servicesfor VAPB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VAPB

Summaries
for VAPB

Genomic Location
for VAPB

Proteins
for VAPB

Protein Domains/
Families
for VAPB

Gene Function
for VAPB

Pathways & Interactions
for VAPB

Drugs & Compounds
for VAPB

Transcripts
for VAPB

Expression
for VAPB

Orthologs
for VAPB

Paralogs
for VAPB

SNPs/Variants
for VAPB

Disorders & Mutations
for VAPB

Medical News
for VAPB

Publications
for VAPB

Licensable Technologies
for VAPB

Services
for VAPB