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VAPA Gene

protein-coding GIFtS: 63

GC18P009904

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
(Previous name: VAMP (vesicle-associated membrane protein)-associated protein A (33kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC3745 ^²
VAMP-A ^³
VAP-33 ^², ³
VAP-A ^¹, ², ³
VAP33 ^², ³, ⁵
hVAP-33 ^¹, ²

Descriptions
33 kDa Vamp-associated protein ^³
VAMP (vesicle-associated membrane protein)-associated protein A (33kD) ^¹, ²
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa ^²
VAMP-associated protein A ^³
vesicle-associated membrane protein-associated protein A ^²

External Ids
HGNC: 12648¹
Entrez Gene: 9218²
UniProtKB: Q9P0L0³
Ensembl: ENSG00000101558⁷

Search outside databases for aliases for VAPA gene

Previous GC identifers: GC18P010047 GC18P009903

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VAPA:

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma

membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein

may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility.

Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms

have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Function: May play a role in vesicle trafficking

Gene Wiki entry for VAPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VAPA gene

Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.2

VAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P009904: (about GC identifiers)

Start:	9,903,955 bp from pter
End:	9,950,018 bp from pter
Size:	46,064 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0 (See protein sequence)

Recommended Name: Vesicle-associated membrane protein-associated protein A

Size: 249 amino acids; 27893 Da

Subunit: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and

with the C-terminal domain of OCLN. Interacts with OSBPL1A

Subcellular location: Cell membrane; Single-pass type IV membrane protein. Endomembrane system;

Single-pass type IV membrane protein. Note=Present in the plasma membrane and in intracellular

vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with

OCLN at the tight junction in polarized epithelial cells

Secondary accessions: O75453 Q5U0E7 Q9UBZ2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003565.4 NP_919415.2

ENSEMBL proteins:

ENSP00000382879 ENSP00000217602 ENSP00000345656 ENSP00000382880

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VAPA)
	Human Recombinant Proteins from Abnova (VAPA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005874	microtubule	IEA	--
GO:0005886	plasma membrane	IDA	10523508
GO:0005923	colocalizes with tight junction	IDA	10523508

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Antibodies for VAPA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of VAPA
	Sigma-Aldrich Antibodies for VAPA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (VAPA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VAPA)
	Novus Biologicals Antibodies for VAPA

Assays for VAPA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9P0L0

ProtoNet protein and cluster: Q9P0L0

1 Blocks protein family: IPB000535 Major sperm protein (MSP) domain

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Similarity: Contains 1 MSP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAPA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_194434

Applied Biosystems Silencer® siRNAs for VAPA

Sigma-Aldrich siRNA and siRNA Panels for VAPA

Sigma-Aldrich shRNA for VAPA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003574
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003574
untagged cDNA clones in CMV expression vector (see all 5): NM_003574

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003574

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Function: May play a role in vesicle trafficking

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IMP	12761501
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	16895911
GO:0046982	protein heterodimerization activity	IPI	9920726 16227268

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for VAPA (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling

GeneDecks VAPA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for VAPA

5/7 Interacting proteins for VAPA (ENSP00000345656³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OSBP	ENSP00000263847³	STRING (score=.889)
ENSG00000220205	ENSP00000314214³	STRING (score=.86)
VAMP1	ENSP00000355122³	STRING (score=.825)
SNAP23	ENSP00000249647³	STRING (score=.798)
VAMP8	ENSP00000263864³	STRING (score=.798)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006944	membrane fusion	TAS	9657962
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP	12761501

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VAPA
2 Novoseek chemical compound relationships for VAPA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	8.98	2	16691359 (1), 15212954 (1)
cholesterol	0.00	1	16173481 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VAPA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_194434

Sigma-Aldrich siRNA and siRNA Panels for VAPA

Sigma-Aldrich shRNA for VAPA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003574 NM_194434

REFSEQ mRNAs for VAPA gene (2 alternative transcripts):

NM_003574.5 NM_194434.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003574 NM_194434

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003574
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003574
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_003574

Additional cDNA sequence:

AF044670.1 AF057358.1 AF086627.1 AF154847.1 AK024299.1 AK096868.1 AK292948.1 AK315577.1

BC002992.1 BC033947.2 BC042860.1 BT019618.1 CR592788.1 CR595148.1 CR607357.1 CR610939.1

CR615746.1 CR616989.1 CR624715.1 CR626025.1 CR626388.1

24 DOTS entries:

DT.442809 DT.439881 DT.95168871 DT.91964878 DT.95168881 DT.40316651 DT.418692 DT.441566

DT.100881374 DT.91665525 DT.100682134 DT.100741929 DT.121089512 DT.91765601 DT.95168872 DT.111436

DT.121089546 DT.121089547 DT.121089558 DT.75154841 DT.85105060 DT.100881377 DT.121089561 DT.95168883

24/598 AceView cDNA sequences (see all 598 ):

AI276053 AA910010 BM975121 CA776260 BU631761 CR607357 AL546692 BM847175

CR595148 BM667470 CR615746 BM713168 BQ685461 AA429360 AA287077 CR626025

BC033947 AW275936 AL534828 BG944670 T16753 F12325 AF086627 AA385910

highest scoring ESTs for VAPA:

AI742846 W95894 AA033624 AA127848 AA136130 AA166921 AA169201 AA169658 AA287076 AA287077

Unigene Cluster for VAPA:

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Hs.699980 [show with all ESTs]

Unigene Representative Sequence: NM_003574

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for VAPA (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d
SP1:									-		-		-				-						-				-
SP2:									-		-		-				-						-
SP3:											-		-				-						-				-
SP4:																	-						-				-
SP5:									-				-				-

About this scheme

ECgene alternative splicing isoforms for VAPA

4 Ensembl transcripts including schematic representations:

ENST00000399999 ENST00000349843 ENST00000340541 ENST00000400000

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VAPA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VAPA

¹ / ² / ³

17 probe-sets matching VAPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89329_at²^{, 3}	U95-E	1	1.00	1.00	0.83	1.38	AI985653	0.80	1.00	0.91	1
46029_r_at²^{, 3}	U95-B	1	1.00	1.00	0.50	0.39	AI671488	0.80	1.00	0.91	1
38801_at²^{, 3}	U95-A	1	1.00	1.00	0.49	1.51	AI742846	1.00	1.00	1.00	1
63624_at²^{, 3}	U95-C	1	1.00	1.00	0.77	0.91	AI253177	0.80	1.00	0.91	1
54663_at²^{, 3}	U95-B	1	1.00	1.00	0.73	1.32	H17359	0.80	1.00	0.91	1
88498_at²^{, 3}	U95-E	1	1.00	1.00	0.84	0.72	W95894	1.00	1.00	1.00	1
80694_at²^{, 3}	U95-D	1	0.94	1.00	0.47	0.89	AI332536	0.60	1.00	0.82	1
239750_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI671488	0.80	1.00	0.91	1
228480_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW296039	0.60	1.00	0.82	1
225198_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL571942	0.60	1.00	0.82	1
208780_x_at²^{, 3}	U133-A	2	1.00	0.86	--	--	AF154847	0.80	0.88	0.84	1
242780_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI332536	0.60	1.00	0.82	1
239750_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228480_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225198_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208780_x_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
242780_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks VAPA for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GTATTTAACA

SOURCE GeneReport for Unigene cluster: Hs.699980
Expression variation in blood from EXPOLDB for VAPA
UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VAPA gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	93.88(n) 95.58(a)	480208 XM_537332.2 XP_537332.1
chimpanzee (Pan troglodytes)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	99.77(n) 100(a)	455288 XM_512022.2 XP_512022.2
cow (Bos taurus)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	88.49(n) 95.18(a)	516024 NM_001075733.1 NP_001069201.1
rat (Rattus norvegicus)	Vapa¹	--	VAMP (vesicle-associated membrane protein)-associated more	91.74(n) 96.69(a)	58857 NM_031631.2 NP_113819.2
mouse (Mus musculus)	Vapa^{1, 5}	17⁵	vesicle-associated membrane protein, associated protein more^{1, 5}	93.71(n)¹ 97.19(a)¹	30960¹ NM_013933.2¹ NP_038961.2¹ AA608327⁵ AF115503⁵ (see all 13)

About this table Species with no ortholog for VAPA

ENSEMBL Gene Tree for VAPA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for VAPA gene

VAPB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/409 NCBI SNPs in VAPA are shown (see all 409 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 297)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs29067^1,2	A,C,F,H,O	9947918(-)	`CGAAGA/CAGCGT`	2	--	ut3¹ ese³		14	EU EA WA NA	2648
	rs29069^1,2	A,C,F,H,O	9945960(-)	`CTGCAC/TTTATG`	2	--	ut3¹		12	EA NA EU WA	1034
	rs28212^1,2	A,C,F,H	9949882(-)	`TTTTGA/GATTAA`	2	--	ut3¹		16	NA MN EU EA WA	1405
	rs29066^1,2	A,C,F,H	9949635(+)	`TGTTAT/CGTACT`	2	--	ut3¹		7	NA EA MN EU WA	582
	rs11081513^1,2	A,C,F,H	9903345(+)	`GAGGAC/TTGGAT`	2	--	ng5¹		14	MN EA EU WA	2510
	rs3070^1,2	A,C,F,H	9948522(-)	`caattA/Ttcttt`	2	--	ut3¹		5	MN EU EA WA	600
	rs3069^1,2	A,C,F,H	9949493(+)	`AACCTA/GCAAGA`	2	--	ut3¹ ese³		16	NA EA MN EU WA	1476
	rs29068^1,2	A,C,F,H	9947573(-)	`CCCTCT/GAATAA`	2	--	ut3¹ ese³		13	EA NA MN EU WA	946
	rs9807392^1,2	C,F,H	9949118(+)	`AGTCTA/GCACAG`	2	--	ut3¹ ese³		11	NA EU EA WA	982
	rs29102^1,2	C,F,H	9945849(-)	`AAAGCA/GTGCAG`	2	--	ut3¹ ese³		9	MN EU EA WA	992

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HapMap Linkage Disequilibrium images for VAPA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605703

2 Novoseek disease relationships for VAPA gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pneumonia	30.19	1	16173481 (1)
aids	0.00	1	9041424 (1)

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Human Genome Epidemiology Navigator: VAPA (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/34 PubMed articles for VAPA gene (see all 34 ):

Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. (PubMed id 9657962)^{1, 2, 3, 4} Weir M.L....Trimble W.S. (1998)
Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. (PubMed id 9920726)^{1, 2, 3, 4} Nishimura Y.... Tanaka T. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
VAP-A binds promiscuously to both v- and tSNAREs. (PubMed id 11511104)^{3, 4} Weir M.L.... Trimble W.S. (2001)
VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. (PubMed id 10523508)^{3, 4} Lapierre L.A.... Anderson J.M. (1999)
Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder. (PubMed id 18665321)^{1, 3} Lohoff F.W....Berrettini W.H. (2008)
Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. (PubMed id 10544080)^{1, 3} Tu H....Lai M.M. (1999)
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. (PubMed id 15016871)^{1, 3} Gao L....Lai M.M. (2004)
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. (PubMed id 16895911)^{1, 3} Kawano M.... Hanada K. (2006)
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication. (PubMed id 15326295)^{1, 3} Evans M.J....Goff S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9218	HGNC: 12648	AceView: VAPA	Ensembl:ENSG00000101558	euGenes: HUgn9218
ECgene: VAPA	H-InvDB: VAPA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for VAPA
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VAPA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VAPA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VAPA		Antibodies for VAPA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VAPA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (VAPA)
	Antibodies (VAPA)
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	Recombinant Proteins (VAPA)
	Antibodies (VAPA)

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Antibodies for VAPA

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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VAPA Gene at Home site.
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VAPA Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VAPA

Summaries
for VAPA

Genomic Location
for VAPA

Proteins
for VAPA

Protein Domains/
Families
for VAPA

Gene Function
for VAPA

Pathways & Interactions
for VAPA

Drugs & Compounds
for VAPA

Transcripts
for VAPA

Expression
for VAPA

Orthologs
for VAPA

Paralogs
for VAPA

SNPs/Variants
for VAPA

Disorders & Mutations
for VAPA

Medical News
for VAPA

Publications
for VAPA

Search for VAPA

Genome Databases showing VAPA

Other Databases showing VAPA

Specialized Databases showing VAPA

Licensable Technologies
for VAPA

Services
for VAPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VAPA Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VAPA

Summariesfor VAPA

Genomic Locationfor VAPA

Proteinsfor VAPA

Protein Domains/Familiesfor VAPA

Gene Functionfor VAPA

Pathways & Interactionsfor VAPA

Drugs & Compoundsfor VAPA

Transcriptsfor VAPA

Expression for VAPA

Orthologsfor VAPA

Paralogsfor VAPA

SNPs/Variantsfor VAPA

Disorders & Mutationsfor VAPA

Medical Newsfor VAPA

Publicationsfor VAPA

Search for VAPA

Genome Databases showing VAPA

Other Databases showing VAPA

Specialized Databases showing VAPA

Licensable Technologiesfor VAPA

Servicesfor VAPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VAPA

Summaries
for VAPA

Genomic Location
for VAPA

Proteins
for VAPA

Protein Domains/
Families
for VAPA

Gene Function
for VAPA

Pathways & Interactions
for VAPA

Drugs & Compounds
for VAPA

Transcripts
for VAPA

Expression
for VAPA

Orthologs
for VAPA

Paralogs
for VAPA

SNPs/Variants
for VAPA

Disorders & Mutations
for VAPA

Medical News
for VAPA

Publications
for VAPA

Licensable Technologies
for VAPA

Services
for VAPA