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VAPA Gene

protein-coding   GIFtS: 66
GCID: GC18P009904

VAMP (Vesicle-Associated Membrane Protein)-Associated Protein...

(Previous name: VAMP (vesicle-associated membrane protein)-associated protein...)
  See VAPA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A,
33kDa1 2
     VAP-A2 3
VAP332 3 5     VAMP-Associated Protein A2 3
33 KDa VAMP-Associated Protein2 3     VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A (33kD)1
VAMP-A2 3     hVAP-332
VAP-332 3     Vesicle-Associated Membrane Protein-Associated Protein A2

External Ids:    HGNC: 126481   Entrez Gene: 92182   Ensembl: ENSG000001015587   OMIM: 6057035   UniProtKB: Q9P0L03   

Export aliases for VAPA gene to outside databases

Previous GC identifers: GC18P010047 GC18P009903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAPA Gene:
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and
intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle
trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this
locus and two transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAPA Gene:
VAPA (VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa) is a protein-coding gene. Diseases associated with VAPA include edwards syndrome, and botulism. GO annotations related to this gene include structural molecule activity and protein heterodimerization activity. An important paralog of this gene is VAPB.

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0
Function: May play a role in vesicle trafficking

Gene Wiki entry for VAPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAPA gene promoter:
         Max1   GATA-3   Sp1   p53   p300   NF-E2 p45   AREB6   CREB   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAPA promoter sequence
   Search Chromatin IP Primers for VAPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.2

VAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAPA gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009904:  view genomic region     (about GC identifiers)

Start:
9,913,955 bp from pter      End:
9,960,018 bp from pter
Size:
46,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein-associated protein A  
Size: 249 amino acids; 27893 Da
Subunit: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the
C-terminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in
the endoplasmic reticulum and regulate its function in cell projections formation. Interacts with OSBP. Interacts
(via C-terminus) with RSAD2/viperin (via C-terminus). Interacts with HCV protein NS5A and NS5B. Interacts with
IFITM3
Sequence caution: Sequence=AAD09742.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF72105.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BG488667;
Type=Frameshift; Positions=72, 207, 241;
1 PDB 3D structure from and Proteopedia for VAPA:
2RR3 (3D)    
Secondary accessions: A6NDZ0 D3DUI3 O75453 Q5U0E7 Q9UBZ2
Alternative splicing: 2 isoforms:  Q9P0L0-1   Q9P0L0-2   

Explore the universe of human proteins at neXtProt for VAPA: NX_Q9P0L0

Explore proteomics data for VAPA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys146, Lys154
  • Modification sites at PhosphoSitePlus

  • See VAPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003565.4  NP_919415.2  

    ENSEMBL proteins: 
     ENSP00000382880   ENSP00000345656   ENSP00000463155  
    Reactome Protein details: Q9P0L0

    VAPA Human Recombinant Protein Products:

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    Novus Biologicals VAPA Proteins
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    Cloud-Clone Corp. Proteins for VAPA

     
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    VAPA Antibody Products:

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    Cloud-Clone Corp. ELISAs for VAPA
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    Search eBioscience for ELISAs for VAPA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008962 PapD-like
     IPR000535 MSP_dom
     IPR016763 Vesicle-associated_membrane

    Graphical View of Domain Structure for InterPro Entry Q9P0L0

    ProtoNet protein and cluster: Q9P0L0

    1 Blocks protein domain: IPB000535 Major sperm protein (MSP) domain

    UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0
    Similarity: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family
    Similarity: Contains 1 MSP domain


    Find genes that share domains with VAPA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAPA_HUMAN, Q9P0L0
    Function: May play a role in vesicle trafficking

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI10544080
    GO:0046982protein heterodimerization activity IPI16227268
         
    Find genes that share ontologies with VAPA           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAPA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAPA

    miRNA
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    miRTarBase miRNAs that target VAPA:
    hsa-mir-421 (MIRT016124), hsa-mir-101-3p (MIRT027325)

    Block miRNA regulation of human, mouse, rat VAPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAPA (see all 165):
    hsa-miR-631 hsa-miR-106a hsa-miR-1245 hsa-miR-519a hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAPA (NM_003574)
    Sino Biological Human cDNA Clone for VAPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAPA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VAPA_HUMAN, Q9P0L0: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Present in the
    plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the
    cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol3
    cytoskeleton2
    endosome1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane IDA10523508
    GO:0005923colocalizes with tight junction IDA10523508

    Find genes that share ontologies with VAPA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAPA About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    4Tight junction
    Tight junction
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with VAPA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for VAPA
        Epithelial Tight Junctions

    1 BioSystems Pathway for VAPA
        Diurnally regulated genes with circadian orthologs


    1 Reactome Pathway for VAPA
        Sphingolipid de novo biosynthesis


    1 Kegg Pathway  (Kegg details for VAPA):
        Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VAPA: 
              Tight Junctions in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VAPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAPA (Q9P0L01, 2, 3 ENSP000003456564) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RMDN3Q96TC72, 3, ENSP000002603854MINT-8276938 I2D: score=2 STRING: ENSP00000260385
    EGFRP005331, 3, ENSP000002754934EBI-1059156,EBI-297353 I2D: score=2 STRING: ENSP00000275493
    OSBPP220593, ENSP000002638474I2D: score=3 STRING: ENSP00000263847
    USP20Q9Y2K63, ENSP000003138114I2D: score=3 STRING: ENSP00000313811
    VAMP2P630273, ENSP000003142144I2D: score=3 STRING: ENSP00000314214
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0007165signal transduction IMP12761501
    GO:0008219cell death IMP19289470
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0031175neuron projection development IMP19289470

    Find genes that share ontologies with VAPA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAPA

    2 Novoseek inferred chemical compound relationships for VAPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 12.5 3 16691359 (1), 19515777 (1), 15212954 (1)
    cholesterol 2.65 3 16173481 (1), 20178991 (1)



    Find genes that share compounds with VAPA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VAPA gene (2 alternative transcripts): 
    NM_003574.5  NM_194434.2  

    Unigene Cluster for VAPA:

    VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
    Hs.165195  [show with all ESTs]
    Unigene Representative Sequence: NM_003574
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400000(uc002koj.3 uc002kok.3) ENST00000577901 ENST00000340541
    ENST00000585042 ENST00000578314 ENST00000584796 ENST00000583879 ENST00000583475
    ENST00000577539
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VAPA (see all 165):
    hsa-miR-631 hsa-miR-106a hsa-miR-1245 hsa-miR-519a hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-130a*
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAPA (NM_003574)
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      QuantiTect SYBR Green Assays in human, mouse, rat VAPA
      QuantiFast Probe-based Assays in human, mouse, rat VAPA

    Additional mRNA sequence: 

    AF044670.1 AF057358.1 AF086627.1 AF154847.1 AK024299.1 AK096868.1 AK292948.1 AK315577.1 
    BC002992.1 BC033947.2 BC042860.1 BT019618.1 

    24 DOTS entries:

    DT.442809  DT.439881  DT.95168871  DT.91964878  DT.95168881  DT.418692  DT.441566  DT.91665525 
    DT.100881374  DT.95168872  DT.100682134  DT.100741929  DT.111436  DT.121089512  DT.121089558  DT.91765601 
    DT.100881377  DT.121089546  DT.121089547  DT.121089561  DT.40316651  DT.75154841  DT.85105060  DT.95168883 

    Selected AceView cDNA sequences (see all 598):

    CD108072 AI242421 AK096868 BM675036 AA858024 BG211423 AA583976 AI363029 
    AA737505 AW591169 AF154847 AA808249 BM559801 BM984860 AA744761 AI186804 
    AW517714 AI752956 AI095475 BM727312 AA773516 BQ928459 AI160120 AI471813 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAPA (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                          -     -     -           -                 -           -                                 
    SP2:                          -     -     -           -                 -                                             
    SP3:                                -     -           -                 -           -                                 
    SP4:                                                  -                 -           -                                 
    SP5:                          -           -           -                                                               


    ECgene alternative splicing isoforms for VAPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTAACA
    VAPA Expression
    About this image


    VAPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    VAPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165195

    UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VAPA: 
              Tight Junctions in human mouse rat
              Diabetes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat VAPA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAPA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vapa1 , 5 vesicle-associated membrane protein, associated protein more1, 5 93.71(n)1
    97.19(a)1
      17 (34.90 cM)5
    309601  NM_013933.31  NP_038961.21 
     655800565 
    chicken
    (Gallus gallus)
    Aves VAPA1 VAMP (vesicle-associated membrane protein)-associated more 87.59(n)
    94.89(a)
      768928  NM_001080869.1  NP_001074338.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAPA6
    VAMP (vesicle-associated membrane protein)-associa...
    80(a)
    1 ↔ 1
    GL343319.1(779898-797029)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.61112 Transcribed sequence with weak similarity to protein more 79.22(n)    141998201 
    zebrafish
    (Danio rerio)
    Actinopterygii vapal1 VAMP (vesicle-associated membrane protein)-associated more 65.29(n)
    73.55(a)
      436819  NM_001002546.1  NP_001002546.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vap-33-13 neuromuscular junction development 53(a)   3F9   --
    worm
    (Caenorhabditis elegans)
    Secernentea vpr-16
    Protein VPR-1 (vpr-1) mRNA, complete cds
    32(a)
    1 → many
    I(5868263-5870114) WBGene00018008
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCS226
    SCS26
    Protein involved in regulation of phospholipid met...
    Integral ER membrane protein that regulates phosph...
    26(a)
    24(a)
    many ↔ many
    many ↔ many
    II(46565-47180) YBL091C-A
    V(401135-401869) YER120W


    ENSEMBL Gene Tree for VAPA (if available)
    TreeFam Gene Tree for VAPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAPA gene
    VAPB2  
    1 SIMAP similar gene for VAPA using alignment to 2 protein entries:     VAPA_HUMAN (see all proteins):
    VAPB

    Find genes that share paralogs with VAPA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VAPA
    PGOHUM00000241893


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for VAPA (see all 1229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467416531,2
    --9911962(+) TCCCAA/GCACTT 2 -- us2k10--------
    rs1394065101,2
    --9912010(+) GTAATC/GCCAGC 2 -- us2k10--------
    rs1931153871,2
    --9912033(+) CAAGGC/TGGGTG 2 -- us2k10--------
    rs99492621,2
    C--9912091(+) CCCCAA/CCTCTA 2 -- us2k10--------
    rs99486191,2
    C--9912170(+) aggcaG/Tgagaa 2 -- us2k10--------
    rs1855274361,2
    --9912442(+) CTGCCC/TATGCC 2 -- us2k10--------
    rs1490932801,2
    --9912492(+) TTTTAC/GAAACC 2 -- us2k10--------
    rs1900009621,2
    --9912632(+) AAGTCC/TCCACC 2 -- us2k10--------
    rs761294741,2
    C--9912783(+) TGGATC/TGCACA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1818808181,2
    C--9912834(+) CGTCTC/TGTTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for VAPA (9913955 - 9960018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VAPA (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1026283CNV Deletion17803354
    esv1000474CNV Deletion20482838
    esv2716779CNV Deletion23290073
    esv5283CNV Deletion18987735
    esv2012315CNV Deletion18987734
    nsv131733CNV Loss16902084
    esv24761CNV Loss19812545
    nsv131589CNV Loss16902084
    nsv526637CNV Loss19592680
    nsv833586CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAPA
    DNA2.0 Custom Variant and Variant Library Synthesis for VAPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605703    OMIM disorders: --

    2 diseases for VAPA:    
    About MalaCards
    edwards syndrome    botulism

    3 diseases from the University of Copenhagen DISEASES database for VAPA:
    Tetanus     Botulism     Myeloma

    Find genes that share disorders with VAPA           About GenesLikeMe

    3 Novoseek inferred disease relationships for VAPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 40.8 1 19515777 (1)
    pneumonia 26.6 1 16173481 (1)
    aids 15.9 1 9041424 (1)

    Genetic Association Database (GAD): VAPA
    Human Genome Epidemiology (HuGE) Navigator: VAPA (2 documents)

    Export disorders for VAPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for VAPA gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with VAPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. (PubMed id 9657962)1, 2, 3, 9 Weir M.L.... Trimble W.S. (Biochem. J. 1998)
    2. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. (PubMed id 9920726)1, 2, 3, 9 Nishimura Y.... Tanaka T. (Biochem. Biophys. Res. Commun. 1999)
    3. Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder. (PubMed id 18665321)1, 4, 9 Lohoff F.W....Berrettini W.H. (J Neural Transm 2008)
    4. Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. (PubMed id 19289470)1, 2, 9 Saita S.... Nakayama K.I. (J. Biol. Chem. 2009)
    5. Electrostatic interaction between oxysterol-binding protein and VAMP- associated protein A revealed by NMR and mutagenesis studies. (PubMed id 20178991)1, 2, 9 Furuita K.... Kojima C. (J. Biol. Chem. 2010)
    6. Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. (PubMed id 21957124)1, 2 Wang S.... Yuan Z. (J. Gen. Virol. 2012)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. VAP-A binds promiscuously to both v- and tSNAREs. (PubMed id 11511104)1, 2 Weir M.L.... Trimble W.S. (Biochem. Biophys. Res. Commun. 2001)
    9. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. (PubMed id 10523508)1, 2 Lapierre L.A.... Anderson J.M. (J. Cell Sci. 1999)
    10. Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. (PubMed id 10544080)1, 9 Tu H....Lai M.M. (Virology 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9218 HGNC: 12648 AceView: VAPA Ensembl:ENSG00000101558 euGenes: HUgn9218
    ECgene: VAPA Kegg: 9218 H-InvDB: VAPA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VAPA gene:
    Search GeneIP for patents involving VAPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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