Aliases for VANGL2 Gene
External Ids for VANGL2 Gene
Previous GeneCards Identifiers for VANGL2 Gene
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
GeneCards Summary for VANGL2 Gene
VANGL2 (VANGL Planar Cell Polarity Protein 2) is a Protein Coding gene. Diseases associated with VANGL2 include Neural Tube Defects and Vangl2-Related Neural Tube Defect. Among its related pathways are Wnt Signaling Pathway and Pluripotency and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is VANGL1.
UniProtKB/Swiss-Prot for VANGL2 Gene
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).