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Aliases & Descriptions for VANGL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA1215 1, 2, 3 | | LPP1 1, 2 | | LTAP 1, 2, 5 | | MGC119403 1, 2 | | MGC119404 1, 2 | | OTTHUMP00000031861 2 | | STB1 1, 2, 3 | | STBM 1, 2 | | STBM1 1, 2 | | strabismus 2 |
| | | Descriptions |
|---|
| Loop-tail protein 1 homolog 3 | | Strabismus 1 3 | | Van Gogh-like protein 2 3 | | loop-tail-associated protein 2 | vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila) 1 | | vang, van gogh-like 2 2 | | vang-like 2 2 | | vang-like 2 (van gogh, Drosophila) 2 |
|
| | Search outside databases for aliases for VANGL2 genePrevious GC identifers: GC01P158177 GC01P156117 GC01P157163 GC01P157585 GC01P157587 GC01P157183 |
Summaries for VANGL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VANGL2: The VANGL2 gene encodes a homolog of Drosophila 'strabismus/Van Gogh' (Stbm/Vang), a component of the frizzled-dishevelled tissue polarity pathway (Kibar et al., 2001 [PubMed 11431695]).[supplied by OMIM] UniProtKB/Swiss-Prot: VANG2_HUMAN, Q9ULK5Function: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity) |
Genomic Location for VANGL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VANGL2 gene 
Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q22-q23VANGL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P158636:
(about GC identifiers)
Start:
|
158,636,988 bp from pter |
End:
|
158,665,088 bp from pter |
Size:
|
28,101 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for VANGL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VANG2_HUMAN, Q9ULK5 (See
protein sequence)Recommended Name: Vang-like protein 2 Size: 521 amino acids; 59714 Da
Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5T212REFSEQ proteins: NP_065068.1
ENSEMBL proteins: ENSP00000357040
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
ISS | -- | About this table
Antibodies for VANGL2: Assays for VANGL2: | Protein
Domains/ Families for VANGL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9ULK5
ProtoNet protein and cluster: Q9ULK5 1 Blocks protein family: IPB009539 Strabismus
UniProtKB/Swiss-Prot: VANG2_HUMAN, Q9ULK5Similarity: Belongs to the Vang family | Gene Function for VANGL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020335
Applied Biosystems Silencer® siRNAs for VANGL2
Sigma-Aldrich siRNA and siRNA Panels for VANGL2  Sigma-Aldrich shRNA for VANGL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020335                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020335                                  untagged cDNA clone in CMV expression vector: NM_020335 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020335
UniProtKB/Swiss-Prot: VANG2_HUMAN, Q9ULK5Function: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity)13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vangl2):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
ISS | -- | About this table | Pathways & Interactions for VANGL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VANGL2 
5/26 Interacting proteins for VANGL2 (ENSP000003570403) via UniProtKB, MINT, and/or STRING (see all 26
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for VANGL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VANGL2
|
Transcripts for VANGL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020335
Sigma-Aldrich siRNA and siRNA Panels for VANGL2  Sigma-Aldrich shRNA for VANGL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020335 REFSEQ mRNAs for VANGL2 gene: NM_020335.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020335               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020335                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020335                                  untagged cDNA clone in CMV expression vector: NM_020335  Additional cDNA sequence: AB033041.1 AK290981.1 AL137558.1 BC103919.2 BC103920.2 4 DOTS entries: DT.436217 DT.40289365 DT.97839802 DT.92413549 24/86 AceView cDNA sequences (see all 86
):BE674679 AI401401 BX505270 CA503116 BM722069 AW662267 BM717001 AB033041 AA298737 AA235772 AI697392 BM678651 CB243283 BX284039 BU162175 T31186 AI906686 AA922668 BX337586 AU253548 AI146407 CA440197 AI934671 T07701
highest scoring ESTs for VANGL2:AI937112 AA235772 AA235773 AA298737 AA302981 AA350988 AA378260 AA379851 AA379863 AA454663 Unigene Cluster for VANGL2: Vang-like 2 (van gogh, Drosophila) Hs.99477 [show with all ESTs]Unigene Representative Sequence: NM_020335
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000368061
|
Expression for VANGL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VANGL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VANGL2
1 / 2 / 3 3 probe-sets matching VANGL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAGAAAATTG
SOURCE GeneReport for Unigene cluster: Hs.99477
|
Orthologs for VANGL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VANGL2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VANGL2
ENSEMBL Gene Tree for VANGL2 | Paralogs for VANGL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VANGL2 gene
- VANGL12
|
SNPs/Variants for VANGL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VANGL2 (up to first 250kb)
|
Disorders & Mutations for VANGL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600533
3 Novoseek disease relationships for VANGL2 gene
About this table
|
Medical News for VANGL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VANGL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for VANGL2 gene (see all 13
):- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. (PubMed id 11431695)2, 3 Kibar Z....Gros P. (2001)
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)3, 4 Nagase T....Ohara O. (1999)
- Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot. (PubMed id 18034999)1, 3 Erdal E....Acikel U. (2007)
- MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. (PubMed id 15195140)3 Yao R....Noda T. (2004)
- Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. (PubMed id 12490194)3 Wharton K.A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. (PubMed id 16687519)1 Montcouquiol M....Kelley M.W. (2006)
- Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. (PubMed id 11709546)1 Murdoch J.N....Stanier P. (2001)
|
Search for VANGL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VANGL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VANGL2
(According to HUGE)
About This Section
| |
Specialized Databases showing VANGL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VANGL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VANGL2:

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Incremental update: 13 Oct 2009
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