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Aliases & Descriptions for VANGL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LPP2 2, 3 | | MGC5338 2 | | OTTHUMP00000013751 2 | | OTTHUMP00000013752 2 | | STB2 1, 2, 3 | | STBM2 2, 5 |
| | | Descriptions |
|---|
| Loop-tail protein 2 homolog 3 | | Strabismus 2 3 | | Van Gogh-like protein 1 3 | | loop-tail protein 2 2 | | van gogh-like 1 2 | | vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 2 | vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila) 1 | | vang-like 1 2 | | vang-like 1 (van gogh, Drosophila) 2 |
|
| | Search outside databases for aliases for VANGL1 genePrevious GC identifers: GC01P116607 GC01P115067 GC01P115332 GC01P115531 GC01P115896 |
Summaries for VANGL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for VANGL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VANGL1 gene 
Entrez Gene cytogenetic band: 1p11-p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13.1VANGL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P115986:
(about GC identifiers)
Start:
|
115,986,097 bp from pter |
End:
|
116,042,368 bp from pter |
Size:
|
56,272 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_019273.18
| Proteins for VANGL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9 (See
protein sequence)Recommended Name: Vang-like protein 1 Size: 524 amino acids; 59975 Da
Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q86WG8 Q8N559Alternative splicing: 2 isoforms: Q8TAA9-1 Q8TAA9-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_620409.1
ENSEMBL proteins: ENSP00000347672 ENSP00000358523 ENSP00000310800 ENSP00000358522
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for VANGL1: Assays for VANGL1: | Protein
Domains/ Families for VANGL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TAA9
ProtoNet protein and cluster: Q8TAA9 1 Blocks protein family: IPB009539 Strabismus
UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9Similarity: Belongs to the Vang family | Gene Function for VANGL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138959
Applied Biosystems Silencer® siRNAs for VANGL1
Sigma-Aldrich siRNA and siRNA Panels for VANGL1  Sigma-Aldrich shRNA for VANGL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138959                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138959                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138959 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_138959
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vangl1):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for VANGL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VANGL1 
5/45 Interacting proteins for VANGL1 (Q8TAA91 ENSP000003585223) via UniProtKB, MINT, and/or STRING (see all 45
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | About this table
|
Drugs & Compounds for VANGL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VANGL1
|
Transcripts for VANGL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138959
Sigma-Aldrich siRNA and siRNA Panels for VANGL1  Sigma-Aldrich shRNA for VANGL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_138959 REFSEQ mRNAs for VANGL1 gene: NM_138959.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138959               OriGene GFP tagged cDNA clone in CMV expression vector: NM_138959                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138959                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138959  Additional cDNA sequence: AB057596.1 AB075805.1 AF481859.1 AK312087.1 BC000907.2 BC032773.1 BC065272.1 BC082967.1 CR609810.1 7 DOTS entries: DT.97839634 DT.100022452 DT.91816078 DT.86846279 DT.121455401 DT.410385 DT.109448 24/140 AceView cDNA sequences (see all 140
):AW294459 BQ687241 BE670545 AA463627 NM_138959 AF481859 AB075805 AI026622 BF968983 AI805666 AI468303 AW675002 AA911207 BU161285 BF726413 CA419348 BC065272 AW452302 CR609810 AA989033 AW469963 BQ576155 AW674666 AA470465
highest scoring ESTs for VANGL1:AA311661 AA603110 H27345 AA311917 AA336623 AA336635 AA336636 AA347877 AA463627 AA789332 Unigene Cluster for VANGL1: Vang-like 1 (van gogh, Drosophila) Hs.515130 [show with all ESTs]Unigene Representative Sequence: NM_138959
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for VANGL1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VANGL1
4 Ensembl transcripts including schematic representations: ENST00000355485
ENST00000369510
ENST00000310260
ENST00000369509
|
Expression for VANGL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VANGL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VANGL1
1 / 2 / 3 14 probe-sets matching VANGL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCCCCAAGG
SOURCE GeneReport for Unigene cluster: Hs.515130 UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9Tissue specificity: Ubiquitous (PubMed:11956595). Expressed specifically in testis and ovary (PubMed:12011995) |
Orthologs for VANGL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VANGL1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VANGL1
ENSEMBL Gene Tree for VANGL1 | Paralogs for VANGL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VANGL1 gene
- VANGL22
|
SNPs/Variants for VANGL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VANGL1 (up to first 250kb)
|
Disorders & Mutations for VANGL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610132 disorders: 600145 182940 UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9
Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis) Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominantHuman Gene Mutation Database: VANGL1 Human Genome Epidemiology Navigator: VANGL1 (1 document)
|
Medical News for VANGL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VANGL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for VANGL1 gene (see all 15
):- Molecular cloning and characterization of Strabismus 2 (STB2). (PubMed id 11956595)1, 2, 3, 4 Katoh M. (2002)
- Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. (PubMed id 12011995)2, 3, 4 Yagyu R....Nakamura Y. (2002)
- Mutations in VANGL1 associated with neural-tube defects. (PubMed id 17409324)3, 4 Kibar Z.... Gros P. (2007)
- Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients. (PubMed id 15952208)3, 4 Doudney K.... Stanier P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Novel Mutations in VANGL1 in Neural Tube Defects. (PubMed id 19319979)3 Kibar Z....Gros P. (2009)
- KITENIN increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. (PubMed id 19166844)3 Lee J.K....Kim K.K. (2009)
- Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. (PubMed id 19249679)3 Wang L....Simeone D.M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. (PubMed id 16410243)3 Kalabis J....Podolsky D.K. (2006)
|
Search for VANGL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VANGL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VANGL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VANGL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VANGL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VANGL1:

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Incremental update: 13 Oct 2009
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