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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VANGL1 Gene

protein-coding   GIFtS: 59
GCID: GC01P116184

vang-like 1 (van gogh, Drosophila)

(Previous names: vang (van gogh, Drosophila)-like 1, vang, van gogh-like...)
 Explore 17 diseases affiliated with
VANGL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VANGL1    

Aliases
for VANGL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vang-Like 1 (Van Gogh, Drosophila)1 2     STBM22 5
STB21 2 3     Vang (Van Gogh, Drosophila)-Like 1, Vang, Van Gogh-Like 1 (Drosophila)1
Loop-Tail Protein 2 Homolog2 3     KITENIN2
Strabismus 22 3     KAI1 C-Terminal Interacting Tetraspanin2
Van Gogh-Like Protein 12 3     Vang-Like Protein 12
LPP22 3     

External Ids:    HGNC: 155121   Entrez Gene: 818392   Ensembl: ENSG000001732187   OMIM: 6101325   UniProtKB: Q8TAA93   

Export aliases for VANGL1 gene to outside databases

Previous GC identifers: GC01P116607 GC01P115067 GC01P115332 GC01P115531 GC01P115896 GC01P115986 GC01P114043


Summaries
for VANGL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VANGL1:
This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal
trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube
defects. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Feb 2010)




Genomic Views
for VANGL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VANGL1 gene promoter:
         c-Fos   AP-1   Pax-5   JunB   Fra-1   FosB   POU3F2   E4BP4   Cdc5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VANGL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VANGL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VANGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

VANGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VANGL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P116184:  view genomic region     (about GC identifiers)

Start:
 116,184,574 bp from pter      End:
 116,240,845 bp from pter
Size:
 56,272 bases      Orientation:
 plus strand

Proteins
for VANGL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9 (See protein sequence)
Recommended Name: Vang-like protein 1  
Size: 524 amino acids; 59975 Da
Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of
DVL1, DVL2 and DVL3 is required for the interaction (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH32773.1; Type=Erroneous initiation;
Secondary accessions: Q5T1D3 Q5T1D4 Q86WG8 Q8N559
Alternative splicing: 2 isoforms:  Q8TAA9-1   Q8TAA9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VANGL1: NX_Q8TAA9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAA9

    • VANGL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001165882.1  NP_001165883.1  NP_620409.1  

    ENSEMBL proteins: 
     ENSP00000358523   ENSP00000310800   ENSP00000358522   ENSP00000347672  

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    Novus Biologicals VANGL1 Proteins
    Novus Biologicals VANGL1 Lysates
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    Uscn Proteins for VANGL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    VANGL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for VANGL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VANGL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009539 Strabismus

    Graphical View of Domain Structure for InterPro Entry Q8TAA9

    ProtoNet protein and cluster: Q8TAA9

    1 Blocks protein family: IPB009539 Strabismus

    UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9
    Similarity: Belongs to the Vang family


    Function
    for VANGL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VANGL1
    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate VANGL1 (see all 129):
    hsa-miR-124* hsa-miR-199a-3p hsa-miR-106a hsa-miR-1245 hsa-miR-1260b hsa-miR-128 hsa-miR-3921 hsa-miR-519a
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    Inhib. RNA
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    OriGene shRNA RFP: VANGL1
    OriGene siRNA: VANGL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VANGL1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for VANGL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VANGL1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15205336


    VANGL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for VANGL1:
     Increased HPV18 LCR reporter a  Synthetic lethal with c-Myc af 

    Animal Models:
         10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vangl1):
     cardiovascular system  embryogenesis  growth/size  hearing/vestibular/ear  limbs/digits/tail 
     mortality/aging  nervous system  normal  reproductive system  respiratory system 

    VANGL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VANGL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for VANGL1):
        Wnt signaling pathway


    VANGL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VANGL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/24 Interacting proteins for VANGL1 (Q8TAA91, 3 ENSP000003108004) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD82P277011, 3, ENSP000002271554EBI-682393,EBI-682379 I2D: score=2 STRING: ENSP00000227155
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=2 STRING: ENSP00000368797
    DVL3Q929973, ENSP000003160544I2D: score=3 STRING: ENSP00000316054
    DVL2O146413, ENSP000000053404I2D: score=4 STRING: ENSP00000005340
    DVL1O146403, ENSP000003681694I2D: score=2 STRING: ENSP00000368169
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--


    VANGL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VANGL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VANGL1
    Search CenterWatch for drugs/clinical trials and news about VANGL1 / VANG1 

    Transcripts
    for VANGL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VANGL1 gene (3 alternative transcripts): 
    NM_001172411.1  NM_001172412.1  NM_138959.2  

    Unigene Cluster for VANGL1:

    Vang-like 1 (van gogh, Drosophila)
    Hs.515130  [show with all ESTs]
    Unigene Representative Sequence: NM_138959
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369510 ENST00000310260 ENST00000369509 ENST00000478369 ENST00000474344
    ENST00000355485(uc009wgy.1 uc001efv.1 uc021ose.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VANGL1
    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate VANGL1 (see all 129):
    hsa-miR-124* hsa-miR-199a-3p hsa-miR-106a hsa-miR-1245 hsa-miR-1260b hsa-miR-128 hsa-miR-3921 hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VANGL1 (see all 7)
    OriGene shRNA RFP: VANGL1
    OriGene siRNA: VANGL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VANGL1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VANGL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VANGL1

    Additional cDNA sequence: 

    AB057596.1 AB075805.1 AF481859.1 AK312087.1 BC000907.2 BC032773.1 BC065272.1 BC082967.1 

    7 DOTS entries:

    DT.97839634  DT.100022452  DT.91816078  DT.121455401  DT.410385  DT.109448  DT.86846279 

    24/140 AceView cDNA sequences (see all 140):

    BF515852 BC065272 AI468303 AA470465 AA312696 AW674666 AW675002 BU161285 
    AI685010 AI805666 BQ576155 AF481859 AI681740 BC000907 AI874246 BQ687241 
    NM_138959 AA911207 AW452302 AA682679 AA463627 AA989033 CR609810 BE670545 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VANGL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:              -                             -     -                           
    SP2:              -                             -     -                           
    SP3:                                            -     -                           
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for VANGL1

    Expression
    for VANGL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VANGL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCCCAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VANGL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VANGL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VANGL1

    SOURCE GeneReport for Unigene cluster: Hs.515130

    UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9
    Tissue specificity: According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed
    specifically in testis and ovary

        SABiosciences Custom PCR Arrays for VANGL1
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    In Situ
    Assay Products:     
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    Orthologs
    for VANGL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for VANGL1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves VANGL11 vang-like 1 (van gogh, Drosophila) 80.59(n)
    88.51(a)    		   418337  XM_001232440.2  XP_001232441.2 
    lizard
    (Anolis carolinensis)    		 Reptilia VANGL16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 2(82768703-82822065)
    zebrafish
    (Danio rerio)    		 Actinopterygii AY279079.12   -- 75.07(n)    AY279079.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Vang1 , 3 establishment and/or maintenance of cell
    polarity3
    Van Gogh1    		 47(a)3
    54.03(n)1
    49.1(a)1    		   359221  NM_057829.31  NP_477177.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0410.2a3
    vang-11    		 Protein VANG-11 34(a)
    (best of 2)3
    46.26(n)1
    36.65(a)1    		   X(2921174-2925603)3
    1805791  NM_076099.21  NP_508500.11 


    ENSEMBL Gene Tree for VANGL1 (if available)
    TreeFam Gene Tree for VANGL1 (if available) 

    Paralogs
    for VANGL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VANGL1 gene
    VANGL22  
    1 SIMAP similar gene for VANGL1 using alignment to 2 protein entries:     VANG1_HUMAN (see all proteins):
    VANGL2

    VANGL1 for paralogs           About GeneDecksing



    Genomic Variants
    for VANGL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1094 NCBI SNPs in VANGL1 are shown (see all 1094)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219182191,2
    		Cpathogenic116224993(+) CCAGCG/AAGCAG 6 /Q /R mis11Minor allele frequency- A:0.00NA 4550
    rs1899714271,2
    		--116182602(+) AGTCTC/TGTTTT 2 -- us2k10--------
    rs1807942571,2
    		--116182726(+) ACCACA/GCCTGG 2 -- us2k10--------
    rs92871711,2
    		C,F,A,H,--116182849(+) CAAGCT/GTCAGC 2 -- us2k17Minor allele frequency- G:0.48WA NA EA 366
    rs92871721,2
    		C,F,A,H,--116182851(+) AGCTTC/GAGCCA 2 -- us2k18Minor allele frequency- G:0.48WA NA CSA EA 367
    rs1424299111,2
    		--116182934(+) CTTTCC/TCACAA 2 -- us2k10--------
    rs1855067521,2
    		--116183042(+) CAGGTA/GCATGA 2 -- us2k10--------
    rs94283511,2
    		C,F,H,--116183127(+) TAATGT/CTCTAC 2 -- us2k19Minor allele frequency- C:0.11NS NA WA CSA 916
    rs570214021,2
    		C,--116183210(+) CAGCAA/GCATCT 2 -- us2k12Minor allele frequency- G:0.21WA 120
    rs2020747441,2
    		C--116183338(+) GGTGTC/TTTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for VANGL1 (116184574 - 116240845 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for VANGL1
         7 CNVs: 84483 74651 74650 64669 60873 2322 3306
    Human Gene Mutation Database (HGMD): VANGL1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for VANGL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VANGL1 for disorders           About GeneDecksing

    OMIM gene information: 610132   
    OMIM disorders: 600145  182940  
    UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9
  • Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The
    • most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida),
    which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open
    dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari
    type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a
    subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a
    mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental
    spinal dysgenesis)
  • Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form
    • of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive
    labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant

    17 diseases for VANGL1:    About MalaCards
    neural tube defect    sacral defect with anterior meningocele    strabismus    caudal regression syndrome
    meningocele    lipomyelomeningocele    spina bifida    myelomeningocele
    anencephaly    hyperopia    constipation    meningitis
    hepatocellular carcinoma    gastric cancer    colorectal cancer    carcinoma
    strabismus 1

    2 diseases from the University of Copenhagen DISEASES database for VANGL1:
    Hyperopia     Spina bifida
    Human Genome Epidemiology (HuGE) Navigator: VANGL1 (2 documents)

    Export disorders for VANGL1 gene to outside databases

    Publications
    for VANGL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VANGL1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with VANGL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of Strabismus 2 (STB2). (PubMed id 11956595)1, 2, 3, 9 Katoh M. (2002)
    2. Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. (PubMed id 12011995)1, 2, 3 Yagyu R....Nakamura Y. (2002)
    3. Novel mutations in VANGL1 in neural tube defects. (PubMed id 19319979)1, 2 Kibar Z.... Gros P. (2009)
    4. Mutations in VANGL1 associated with neural-tube defects. (PubMed id 17409324)1, 2 Kibar Z.... Gros P. (2007)
    5. Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients. (PubMed id 15952208)1, 2 Doudney K.... Stanier P. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A protein complex of SCRIB, NOS1AP and VANGL1 regulate s cell polarity and migration, and is associated with breast cancer progression. (PubMed id 22179838)1 Anastas J.N....Moon R.T. (2012)
    9. Transmembrane topology of mammalian planar cell polar ity protein Vangl1. (PubMed id 21291170)1 Iliescu A....Gros P. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for VANGL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing VANGL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81839 HGNC: 15512 AceView: VANGL1 Ensembl:ENSG00000173218 euGenes: HUgn81839
    ECgene: VANGL1 Kegg: 81839 H-InvDB: VANGL1

    Other Databases showing VANGL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VANGL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VANGL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VANGL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VANGL1 gene:
    Search GeneIP for patents involving VANGL1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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