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VANGL1 Gene

protein-coding GIFtS: 60

GC01P115986

vang-like 1 (van gogh, Drosophila)
(Previous names: vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LPP2 ^², ³
MGC5338 ^²
OTTHUMP00000013751 ^²
OTTHUMP00000013752 ^²
STB2 ^¹, ², ³
STBM2 ^², ⁵

Descriptions
Loop-tail protein 2 homolog ^³
Strabismus 2 ^³
Van Gogh-like protein 1 ^³
loop-tail protein 2 ^²
van gogh-like 1 ^²
vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 ^²
vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila) ^¹
vang-like 1 ^²
vang-like 1 (van gogh, Drosophila) ^²

External Ids
HGNC: 15512¹
Entrez Gene: 81839²
UniProtKB: Q8TAA9³
Ensembl: ENSG00000173218⁷

Search outside databases for aliases for VANGL1 gene

Previous GC identifers: GC01P116607 GC01P115067 GC01P115332 GC01P115531 GC01P115896

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VANGL1 gene

Entrez Gene cytogenetic band: 1p11-p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13.1

VANGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P115986: (about GC identifiers)

Start:	115,986,097 bp from pter
End:	116,042,368 bp from pter
Size:	56,272 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9 (See protein sequence)

Recommended Name: Vang-like protein 1

Size: 524 amino acids; 59975 Da

Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3.

The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q86WG8 Q8N559

Alternative splicing: 2 isoforms: Q8TAA9-1 Q8TAA9-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_620409.1

ENSEMBL proteins:

ENSP00000347672 ENSP00000358523 ENSP00000310800 ENSP00000358522

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VANGL1)
	Human Recombinant Proteins from Abnova (VANGL1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for VANGL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for VANGL1
	R&D Systems Antibodies for VANGL1 (Vang-like Protein 1/VANGL1)
	Antibodies from Abcam (VANGL1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (VANGL1)
	Novus Biologicals Antibodies for VANGL1

Assays for VANGL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8TAA9

ProtoNet protein and cluster: Q8TAA9

1 Blocks protein family: IPB009539 Strabismus

UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9

Similarity: Belongs to the Vang family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VANGL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138959

Applied Biosystems Silencer® siRNAs for VANGL1

Sigma-Aldrich siRNA and siRNA Panels for VANGL1

Sigma-Aldrich shRNA for VANGL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VANGL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_138959
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138959
untagged cDNA clones in CMV expression vector (see all 2): NM_138959

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_138959

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vangl1):

hearing/vestibular/ear

lethality-prenatal/perinatal

limbs/digits/tail

nervous system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15205336

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for VANGL1

5/45 Interacting proteins for VANGL1 (Q8TAA9¹ ENSP00000358522³) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD82	P27701¹, ENSP00000227155³	EBI-682393, EBI-682379 STRING (score=.783)
DVL1L1	ENSP00000368166³	STRING (score=.982)
DVL2	ENSP00000005340³	STRING (score=.982)
DVL3	ENSP00000316054³	STRING (score=.982)
PRICKLE2	ENSP00000295902³	STRING (score=.946)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VANGL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VANGL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138959

Sigma-Aldrich siRNA and siRNA Panels for VANGL1

Sigma-Aldrich shRNA for VANGL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_138959

REFSEQ mRNAs for VANGL1 gene:

NM_138959.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_138959

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138959
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138959
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_138959

Additional cDNA sequence:

AB057596.1 AB075805.1 AF481859.1 AK312087.1 BC000907.2 BC032773.1 BC065272.1 BC082967.1

CR609810.1

7 DOTS entries:

DT.97839634 DT.100022452 DT.91816078 DT.86846279 DT.121455401 DT.410385 DT.109448

24/140 AceView cDNA sequences (see all 140 ):

AW294459 BQ687241 BE670545 AA463627 NM_138959 AF481859 AB075805 AI026622

BF968983 AI805666 AI468303 AW675002 AA911207 BU161285 BF726413 CA419348

BC065272 AW452302 CR609810 AA989033 AW469963 BQ576155 AW674666 AA470465

highest scoring ESTs for VANGL1:

AA311661 AA603110 H27345 AA311917 AA336623 AA336635 AA336636 AA347877 AA463627 AA789332

Unigene Cluster for VANGL1:

Vang-like 1 (van gogh, Drosophila)

Hs.515130 [show with all ESTs]

Unigene Representative Sequence: NM_138959

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for VANGL1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10
SP1:					-										-		-
SP2:					-										-		-
SP3:															-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for VANGL1

4 Ensembl transcripts including schematic representations:

ENST00000355485 ENST00000369510 ENST00000310260 ENST00000369509

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VANGL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VANGL1

¹ / ² / ³

14 probe-sets matching VANGL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76954_at²^{, 3}	U95-E	1	1.00	1.00	0.92	0.90	R85437	0.40	1.00	0.76	1
46136_at²^{, 3}	U95-B	1	1.00	1.00	0.74	1.11	W68637	0.60	1.00	0.82	1
50855_at²^{, 3}	U95-B	1	1.00	1.00	0.77	0.56	AA789332	0.80	1.00	0.91	1
56095_at²^{, 3}	U95-B	1	1.00	1.00	0.82	0.94	AA603110	1.00	1.00	1.00	1
80582_at²^{, 3}	U95-D	1	0.94	1.00	-0.02	1.53	AA311661	1.00	1.00	1.00	1
80950_r_at²^{, 3}	U95-E	1	0.88	1.00	0.92	1.01	H27345	1.00	1.00	1.00	1
229492_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R85437	0.40	1.00	0.76	1
219330_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024062	0.20	1.00	0.72	1
229134_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF509230	0.40	1.00	0.76	1
229997_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AA789332	0.80	1.00	0.91	1
229492_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219330_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229134_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229997_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks VANGL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCCCCAAGG

SOURCE GeneReport for Unigene cluster: Hs.515130
UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9
Tissue specificity: Ubiquitous (PubMed:11956595). Expressed specifically in testis and ovary
(PubMed:12011995)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VANGL1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VANGL1¹	--	vang-like 1 (van gogh, Drosophila)	90.39(n) 96.56(a)	483133 XM_852285.1 XP_857378.1
chimpanzee (Pan troglodytes)	VANGL1¹	--	vang-like 1 (van gogh, Drosophila)	99.43(n) 99.62(a)	457149 XM_001148705.1 XP_001148705.1
cow (Bos taurus)	VANGL1¹	--	vang-like 1 (van gogh, Drosophila)	90.46(n) 96.18(a)	513056 XM_590678.3 XP_590678.3
rat (Rattus norvegicus)	Vangl1¹	--	vang-like 1 (van gogh, Drosophila)	88.74(n) 95.61(a)	690366 XM_001072392.1 XP_001072392.1
mouse (Mus musculus)	Vangl1^{1, 5}	3⁵	vang-like 1 (van gogh, Drosophila)^{1, 5}	88.61(n)¹ 95.23(a)¹	229658¹ NM_177545.3¹ NP_808213.1¹ AA387807⁵ AF481860⁵ (see all 12)

About this table Species with no ortholog for VANGL1

ENSEMBL Gene Tree for VANGL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VANGL1 gene

VANGL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/412 NCBI SNPs in VANGL1 are shown (see all 412 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 192)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3204955^1,2	A,C,F,H,O	116036800(+)	`AAACAC/TAGCTG`	1	--	ut3¹ ese³		12	MN NA EA EU WA	1096
	rs4348723^1,2	A,C,F,H	116041156(+)	`TGTGCT/GTATCT`	1	--	ut3¹		11	NA EU EA WA	980
	rs12121158^1,2	A,C,F,H	116037874(+)	`TTACTG/TTTGCA`	1	--	ut3¹		16	EA NA EU WA	1472
	rs10494179^1,2	A,C,F,H	116040891(+)	`AAAGAG/ACAGAT`	1	--	ut3¹		12	NS NA EU EA WA	664
	rs4839472^1,2	A,C,F,H	116039019(+)	`TGTCAT/ATGTGT`	1	--	ut3¹		11	NA EU EA WA	978
	rs6428677^1,2	A,C,F,H	116041549(+)	`TTTACG/AGTAGG`	1	--	ut3¹		7	NA EU EA WA	560
	rs6668400^1,2	A,C,F,H	116042444(+)	`ACTCTC/TGCATA`	1	--	ng3¹		6	NA EA WA	438
	rs10801933^1,2	A,C,F,H	116041274(+)	`GGACCA/GGAGAC`	1	--	ut3¹		7	NA EU EA WA	516
	rs10923204^1,2	A,C,F,H	116038546(+)	`GCCTGG/TGGCTT`	1	--	ut3¹		4	EU EA WA	408
	rs2999459^1,2	C,F,H,O	115985165(+)	`AGAAAA/GGTGCA`	1	--	ng5¹		4	EU EA WA	408

About this table

HapMap Linkage Disequilibrium images for VANGL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610132 disorders: 600145 182940

UniProtKB/Swiss-Prot: VANG1_HUMAN, Q8TAA9

Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are

congenital malformations. The most common forms of NTD are described as open defects (including

anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the

cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including

myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type

2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the

presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and

myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord

malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis)

Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM)

[MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic

later in life, usually because of obstructive labor in females, chronic constipation, or

meningitis. Inheritance is autosomal dominant

Human Gene Mutation Database: VANGL1
Human Genome Epidemiology Navigator: VANGL1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/15 PubMed articles for VANGL1 gene (see all 15 ):

Molecular cloning and characterization of Strabismus 2 (STB2). (PubMed id 11956595)^{1, 2, 3, 4} Katoh M. (2002)
Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. (PubMed id 12011995)^{2, 3, 4} Yagyu R....Nakamura Y. (2002)
Mutations in VANGL1 associated with neural-tube defects. (PubMed id 17409324)^{3, 4} Kibar Z.... Gros P. (2007)
Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients. (PubMed id 15952208)^{3, 4} Doudney K.... Stanier P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Novel Mutations in VANGL1 in Neural Tube Defects. (PubMed id 19319979)³ Kibar Z....Gros P. (2009)
KITENIN increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. (PubMed id 19166844)³ Lee J.K....Kim K.K. (2009)
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. (PubMed id 19249679)³ Wang L....Simeone D.M. (2009)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. (PubMed id 16410243)³ Kalabis J....Podolsky D.K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 81839	HGNC: 15512	AceView: VANGL1	Ensembl:ENSG00000173218	euGenes: HUgn81839
ECgene: VANGL1	H-InvDB: VANGL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for VANGL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VANGL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VANGL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VANGL1		Antibodies for VANGL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VANGL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VANGL1)
	Antibodies (VANGL1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (VANGL1)

Search OriGene for VANGL1

Search Tocris compounds for VANGL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for VANGL1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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VANGL1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for VANGL1

Summaries
for VANGL1

Genomic Location
for VANGL1

Proteins
for VANGL1

Protein Domains/
Families
for VANGL1

Gene Function
for VANGL1

Pathways & Interactions
for VANGL1

Drugs & Compounds
for VANGL1

Transcripts
for VANGL1

Expression
for VANGL1

Orthologs
for VANGL1

Paralogs
for VANGL1

SNPs/Variants
for VANGL1

Disorders & Mutations
for VANGL1

Medical News
for VANGL1

Publications
for VANGL1

Search for VANGL1

Genome Databases showing VANGL1

Other Databases showing VANGL1

Specialized Databases showing VANGL1

Licensable Technologies
for VANGL1

Services
for VANGL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VANGL1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor VANGL1

Summariesfor VANGL1

Genomic Locationfor VANGL1

Proteinsfor VANGL1

Protein Domains/Familiesfor VANGL1

Gene Functionfor VANGL1

Pathways & Interactionsfor VANGL1

Drugs & Compoundsfor VANGL1

Transcriptsfor VANGL1

Expression for VANGL1

Orthologsfor VANGL1

Paralogsfor VANGL1

SNPs/Variantsfor VANGL1

Disorders & Mutationsfor VANGL1

Medical Newsfor VANGL1

Publicationsfor VANGL1

Search for VANGL1

Genome Databases showing VANGL1

Other Databases showing VANGL1

Specialized Databases showing VANGL1

Licensable Technologiesfor VANGL1

Servicesfor VANGL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VANGL1

Summaries
for VANGL1

Genomic Location
for VANGL1

Proteins
for VANGL1

Protein Domains/
Families
for VANGL1

Gene Function
for VANGL1

Pathways & Interactions
for VANGL1

Drugs & Compounds
for VANGL1

Transcripts
for VANGL1

Expression
for VANGL1

Orthologs
for VANGL1

Paralogs
for VANGL1

SNPs/Variants
for VANGL1

Disorders & Mutations
for VANGL1

Medical News
for VANGL1

Publications
for VANGL1

Licensable Technologies
for VANGL1

Services
for VANGL1