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Aliases for VAMP8 Gene

Aliases for VAMP8 Gene

  • Vesicle-Associated Membrane Protein 8 2 3
  • Endobrevin 2 4
  • VAMP-8 3 4
  • EDB 3 4
  • Vesicle-Associated Membrane Protein 8 (Endobrevin) 3

External Ids for VAMP8 Gene

Previous GeneCards Identifiers for VAMP8 Gene

  • GC02P085700
  • GC02P086098
  • GC02P085779
  • GC02P085716
  • GC02P085658
  • GC02P085788
  • GC02P085701

Summaries for VAMP8 Gene

Entrez Gene Summary for VAMP8 Gene

  • This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

GeneCards Summary for VAMP8 Gene

VAMP8 (Vesicle-Associated Membrane Protein 8) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP8 Gene

  • SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.

Gene Wiki entry for VAMP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP8 Gene

Genomics for VAMP8 Gene

Regulatory Elements for VAMP8 Gene

Genomic Location for VAMP8 Gene

Start:
85,561,562 bp from pter
End:
85,582,033 bp from pter
Size:
20,472 bases
Orientation:
Plus strand

Genomic View for VAMP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP8 Gene

Proteins for VAMP8 Gene

  • Protein details for VAMP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV40-VAMP8_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 8
    Protein Accession:
    Q9BV40
    Secondary Accessions:
    • O60625
    • Q53SP9
    • Q6IB09

    Protein attributes for VAMP8 Gene

    Size:
    100 amino acids
    Molecular mass:
    11438 Da
    Quaternary structure:
    • Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome. Binds tightly to multiple syntaxins. Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B.

    Three dimensional structures from OCA and Proteopedia for VAMP8 Gene

neXtProt entry for VAMP8 Gene

Proteomics data for VAMP8 Gene at MOPED

Post-translational modifications for VAMP8 Gene

  • Ubiquitination at Lys24, Lys47, Lys59, and Lys64
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAMP8 (VAMP8)

No data available for DME Specific Peptides for VAMP8 Gene

Domains for VAMP8 Gene

Gene Families for VAMP8 Gene

HGNC:
  • VAMP :Vesicle-associated membrane proteins

Protein Domains for VAMP8 Gene

Suggested Antigen Peptide Sequences for VAMP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV40

UniProtKB/Swiss-Prot:

VAMP8_HUMAN :
  • Q9BV40
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP8: view

Function for VAMP8 Gene

Molecular function for VAMP8 Gene

GENATLAS Biochemistry: vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early endosome,involved in regulating membrane traffic
UniProtKB/Swiss-Prot Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.

Gene Ontology (GO) - Molecular Function for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 23217709
GO:0019869 chloride channel inhibitor activity IDA 18570918
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with VAMP8: view
genes like me logo Genes that share phenotypes with VAMP8: view

Animal Model Products

miRNA for VAMP8 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VAMP8 Gene

Localization for VAMP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP8 Gene

Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP8 Gene COMPARTMENTS Subcellular localization image for VAMP8 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 4
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18253931
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane IDA 23217709
GO:0005769 early endosome TAS 9614193
GO:0005829 cytosol IDA 22589474
genes like me logo Genes that share ontologies with VAMP8: view

Pathways for VAMP8 Gene

genes like me logo Genes that share pathways with VAMP8: view

Gene Ontology (GO) - Biological Process for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000046 autophagic vacuole fusion IMP 23217709
GO:0006461 protein complex assembly --
GO:0006887 exocytosis IBA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006897 endocytosis IBA --
genes like me logo Genes that share ontologies with VAMP8: view

Transcripts for VAMP8 Gene

mRNA/cDNA for VAMP8 Gene

Unigene Clusters for VAMP8 Gene

Vesicle-associated membrane protein 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAMP8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for VAMP8 Gene

GeneLoc Exon Structure for
VAMP8
ECgene alternative splicing isoforms for
VAMP8

Expression for VAMP8 Gene

mRNA expression in normal human tissues for VAMP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP8 Gene

SOURCE GeneReport for Unigene cluster for VAMP8 Gene Hs.714302

mRNA Expression by UniProt/SwissProt for VAMP8 Gene

Q9BV40-VAMP8_HUMAN
Tissue specificity: Platelets
genes like me logo Genes that share expressions with VAMP8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VAMP8 Gene

Orthologs for VAMP8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP8 35
  • 99.33 (n)
  • 100 (a)
VAMP8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP8 35
  • 87.41 (n)
  • 92.86 (a)
VAMP8 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAMP8 35
  • 91.33 (n)
  • 94 (a)
VAMP8 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp8 35
  • 84.67 (n)
  • 87 (a)
Vamp8 16
Vamp8 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAMP8 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp8 35
  • 84.01 (n)
  • 86.73 (a)
lizard
(Anolis carolinensis)
Reptilia VAMP8 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp8 35
  • 71 (n)
  • 70 (a)
zebrafish
(Danio rerio)
Actinopterygii vamp8 35
  • 67.41 (n)
  • 66.67 (a)
vamp8 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vamp-7 36
  • 13 (a)
OneToMany
vamp-8 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 21 (a)
ManyToMany
SNC2 36
  • 21 (a)
ManyToMany
Species with no ortholog for VAMP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP8 Gene

ENSEMBL:
Gene Tree for VAMP8 (if available)
TreeFam:
Gene Tree for VAMP8 (if available)

Paralogs for VAMP8 Gene

Paralogs for VAMP8 Gene

Selected SIMAP similar genes for VAMP8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VAMP8: view

Variants for VAMP8 Gene

Sequence variations from dbSNP and Humsavar for VAMP8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1009 -- 85,581,614(-) AATTT(C/T)CGAGC reference, synonymous-codon
rs1010 -- 85,581,859(-) ACAAC(A/C/G)TGGCA utr-variant-3-prime
rs1011 -- 85,581,613(-) TTTTT(C/T)GGAGC missense, reference
rs1058588 -- 85,581,748(+) CTTCT(C/T)TTCAG utr-variant-3-prime
rs1058615 -- 85,581,908(+) AAAAA(A/G)AGAGA utr-variant-3-prime

Relevant External Links for VAMP8 Gene

HapMap Linkage Disequilibrium report
VAMP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VAMP8 Gene

Disorders for VAMP8 Gene

Relevant External Links for VAMP8

Genetic Association Database (GAD)
VAMP8
Human Genome Epidemiology (HuGE) Navigator
VAMP8
genes like me logo Genes that share disorders with VAMP8: view

No data available for UniProtKB/Swiss-Prot for VAMP8 Gene

Publications for VAMP8 Gene

  1. Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PMID: 9614193) Wong S.H. … Hong W. (Mol. Biol. Cell 1998) 2 3 4 23
  2. Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PMID: 9878266) Bui T.D. … Hong W. (Genomics 1998) 2 3 23
  3. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PMID: 17255364) Lapierre L.A. … Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007) 3 23
  4. Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. (PMID: 16195891) Oishi Y. … Takuma T. (Histochem. Cell Biol. 2006) 3 23
  5. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. (PMID: 18253931) Sander L.E. … Lorentz A. (Eur. J. Immunol. 2008) 3 23

Products for VAMP8 Gene

Sources for VAMP8 Gene

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