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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VAMP8 Gene

protein-coding GIFtS: 63
GCID: GC02P085788

vesicle-associated membrane protein 8

Explore 11 diseases affiliated with
VAMP8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vesicle-Associated Membrane Protein 8¹ ²
EDB¹ ² ³
VAMP-8² ³
Vesicle-Associated Membrane Protein 8 (Endobrevin)²
Endobrevin³

External Ids:	HGNC: 12647¹	Entrez Gene: 8673²	Ensembl: ENSG00000118640⁷	OMIM: 603177⁵	UniProtKB: Q9BV40³

Export aliases for VAMP8 gene to outside databases

Previous GC identifers: GC02P085700 GC02P086098 GC02P085779 GC02P085716 GC02P085658 GC02P085701

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP8:

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein

subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is

involved in the fusion of synaptic vesicles with the presynaptic membrane.(provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40

Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for

dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved

in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in

the homotypic fusion of early and late endosomes (By similarity)

Gene Wiki entry for VAMP8 (Vesicle-associated membrane protein 8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VAMP8 gene promoter:
c-Fos AP-1 JunB FosB Olf-1 JunD E2F-1 E2F Msx-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VAMP8 promoter sequence

Search SABiosciences Chromatin IP Primers for VAMP8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12-p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p12-p11.2

VAMP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP8 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P085788: view genomic region (about GC identifiers)

Start:	85,788,685 bp from pter	End:	85,809,156 bp from pter
Size:	20,472 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40 (See protein sequence)

Recommended Name: Vesicle-associated membrane protein 8

Size: 100 amino acids; 11438 Da

Subunit: Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (By

similarity). Interacts with STX8 (By similarity)

Subcellular location: Membrane; Single-pass type IV membrane protein (Probable)

Secondary accessions: O60625 Q53SP9 Q6IB09

Explore the universe of human proteins at neXtProt for VAMP8: NX_Q9BV40

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BV40

VAMP8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003752.2

ENSEMBL proteins:

ENSP00000407984 ENSP00000263864 ENSP00000387094

Reactome Protein details: Q9BV40
Human Recombinant Protein Products:

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	Uscn Proteins for VAMP8

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005765	lysosomal membrane	IEA	--
GO:0005769	early endosome	TAS	9614193
GO:0005886	plasma membrane	TAS	--

VAMP8 for ontologies About GeneDecksing

VAMP8 Antibody Products:

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	Uscn ELISAs and CLIAs for VAMP8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VAMP8 for domains About GeneDecksing

2 InterPro domains/families:

IPR016444 Synaptobrevin_met/fun

IPR001388 Synaptobrevin

Graphical View of Domain Structure for InterPro Entry Q9BV40

ProtoNet protein and cluster: Q9BV40

1 Blocks protein family: IPB001388 Synaptobrevin

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40

Similarity: Belongs to the synaptobrevin family

Similarity: Contains 1 v-SNARE coiled-coil homology domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40

Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for

dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved

in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in

the homotypic fusion of early and late endosomes (By similarity)

Genatlas biochemistry entry for VAMP8:

vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N

ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early endosome,involved

in regulating membrane traffic

miRNA Products:		OriGene 3'-UTR Clone: VAMP8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP8
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP8 (see all 12):
		hsa-miR-15a hsa-miR-497 hsa-miR-1179 hsa-miR-455-3p hsa-miR-103a hsa-miR-424 hsa-miR-4310 hsa-miR-556-3p

		SwitchGear 3'UTR luciferase reporter plasmid: VAMP8 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VAMP8

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		Search LifeMap BioReagents cell lines for VAMP8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP8

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0019905	syntaxin binding	IEA	--

VAMP8 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for VAMP8:

G0/1 arrest

Increased G1 DNA content

Increased cell size

Animal Models:
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Vamp8):

behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	mortality/aging	renal/urinary system

VAMP8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Clathrin derived vesicle budding

	Clathrin derived vesicle budding	1.00			Golgi Associated Vesicle Biogenesis	0.89
	trans-Golgi Network Vesicle Budding	1.00			Lysosome Vesicle Biogenesis	0.39

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1.00

SNARE interactions in vesicular transport

0.40

Clathrin-dependent protein traffic

Transport_Clathrin-coated vesicle cycle

0.66

wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)

0.37

wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

1.00

Membrane Trafficking

Membrane Trafficking

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 GeneGo (Thomson Reuters) Pathways for VAMP8

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Transport Clathrin-coated vesicle cycle
	wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

5 Reactome Pathways for VAMP8

	Membrane Trafficking
	Clathrin derived vesicle budding
	Golgi Associated Vesicle Biogenesis
	trans-Golgi Network Vesicle Budding
	Lysosome Vesicle Biogenesis

1 PharmGKB Pathway for VAMP8

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1 Kegg Pathway (Kegg details for VAMP8):

SNARE interactions in vesicular transport

VAMP8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VAMP8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for VAMP8 (Q9BV40^{2, 3} ENSP00000263864⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STX8	Q9UNK0²^,³, ENSP00000305255⁴	MINT-7255609 I2D: score=2 STRING: ENSP00000305255
STX7	O15400²^,³, ENSP00000356918⁴	MINT-7255609 I2D: score=3 STRING: ENSP00000356918
STX6	O43752²^,³, ENSP00000258301⁴	MINT-7255609 I2D: score=1 STRING: ENSP00000258301
STX4	Q12846³, ENSP00000317714⁴	I2D: score=3 STRING: ENSP00000317714
VAMP2	P63027³, ENSP00000314214⁴	I2D: score=3 STRING: ENSP00000314214

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	IEA	--
GO:0006892	post-Golgi vesicle-mediated transport	TAS	--
GO:0006906	vesicle fusion	IEA	--
GO:0006944	cellular membrane fusion	--	--
GO:0016044	cellular membrane organization	TAS	--

VAMP8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VAMP8
Search CenterWatch for drugs/clinical trials and news about VAMP8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VAMP8 gene:

NM_003761.4

Unigene Cluster for VAMP8:

Vesicle-associated membrane protein 8

Hs.714302 [show with all ESTs]

Unigene Representative Sequence: BU199072

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000432071 ENST00000263864(uc002spt.4) ENST00000409760

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP8
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP8 (see all 12):
		hsa-miR-15a hsa-miR-497 hsa-miR-1179 hsa-miR-455-3p hsa-miR-103a hsa-miR-424 hsa-miR-4310 hsa-miR-556-3p

		SwitchGear 3'UTR luciferase reporter plasmid: VAMP8 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: VAMP8 (NM_003761)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP8

Additional cDNA sequence:

AF053233.1 BC001634.1 BT006700.1 CR456995.1

13 DOTS entries:

DT.75123759 DT.101963601 DT.100861790 DT.95201826 DT.91891588 DT.97780127 DT.121006292 DT.91732827

DT.92024796 DT.92431989 DT.95201827 DT.87011100 DT.92431991

24/316 AceView cDNA sequences (see all 316):

BI836255 BQ021316 BM707971 BM887680 AA176219 F27921 AI079353 D19625

AA836089 BM702226 CR594380 W80846 AA305331 AA361428 BQ675243 NM_006634

AA634593 AI568721 CD369345 BC017891 AF077197 CB108371 CR542215 CB156929

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP8 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:
SP2:											-
SP3:											-		-
SP4:

ECgene alternative splicing isoforms for VAMP8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VAMP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCTGGGAA

About this image

VAMP8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Podocytes

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

See VAMP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VAMP8

SOURCE GeneReport for Unigene cluster: Hs.714302

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40

Tissue specificity: Platelets

SABiosciences Custom PCR Arrays for VAMP8

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for VAMP8 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	VAMP8⁶	--	62(a)	1 ↔ 1	AAWZ02038425(2887-8111)
zebrafish (Danio rerio)	Actinopterygii	vamp8¹	vesicle-associated membrane protein 8 (endobrevin)	68.58(n) 68.97(a)		327007 NM_199759.1 NP_956053.1
worm (Caenorhabditis elegans)	Secernentea	B0513.9⁶ Y69A2AR.6⁶	--	30(a) 14(a)	1 ↔ many 1 ↔ many	IV(13860119-13865269) IV(2608047-2610210)
thale cress (Arabidopsis thaliana)	eudicotyledons	VAMP728⁶ ATVAMP726⁶ (see all 8)	vesicle-associated membrane protein 72 (see all 8)	17(a) 13(a) (see all 8)	possible ortholog possible ortholog (see all 8)	3(9097514-9098945) 1(1334760-1336070)
rice (Oryza sativa)	Liliopsida	-- -- (see all 6)	vesicle-associated membrane protein, putative, exp... vesicle-associated membrane protein, putative, exp... (see all 6)	15(a) 13(a) (see all 6)	possible ortholog possible ortholog (see all 6)	3(3550771-3553411) 7(5094639-5098513)

ENSEMBL Gene Tree for VAMP8 (if available)
TreeFam Gene Tree for VAMP8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VAMP8 gene

VAMP2² VAMP1² VAMP5² VAMP3² VAMP4² ENSG00000263620²

6 SIMAP similar genes for VAMP8 using alignment to 3 protein entries: VAMP8_HUMAN (see all proteins):

VAMP4 VAMP2 VAMP1 VAMP3 VAMP5 SYBL1

VAMP8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56359002^1,2	C,	--	85802660(+)	`AAAAGC/TTACAG`	1	--	us2k¹		3		WA NA	240
rs145475141^1,2		--	85802708(+)	`TGTGGC/TCGGGC`	1	--	us2k¹		0	--	--	--	--
rs147698609^1,2		--	85802709(+)	`GTGGCC/TGGGCG`	1	--	us2k¹		0	--	--	--	--
rs55892665^1,2		--	85802754(+)	`AGGCCA/GAGGCG`	1	--	us2k¹		0	--	--	--	--
rs150195109^1,2		--	85802906(+)	`AAAATC/TGCTTG`	1	--	us2k¹		0	--	--	--	--
rs145593867^1,2		--	85802950(+)	`TAGCGC/GCATTG`	1	--	us2k¹		0	--	--	--	--
rs200547246^1,2		--	85803072(+)	`GAGGA-/TTACTT`	1	--	us2k¹		0	--	--	--	--
rs148915755^1,2		--	85803165(+)	`ATGGCA/GGTTCG`	1	--	us2k¹		0	--	--	--	--
rs188890313^1,2		--	85803174(+)	`CGCACC/TTGTAG`	1	--	us2k¹		0	--	--	--	--
rs13425821^1,2	C,F,A,	--	85803242(+)	`tgcagG/Tgtgct`	1	--	us2k¹		6		WA NA CSA	246

HapMap Linkage Disequilibrium report for VAMP8 (85788685 - 85809156 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VAMP8: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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VAMP8 for disorders           About GeneDecksing

OMIM gene information: 603177    OMIM disorders: --

11 diseases for VAMP8:    About MalaCards

open-angle glaucoma primary open angle glaucoma glaucoma coronary heart disease

myocardial infarction kidney disease pancreatic cancer pancreatitis

hypertension melanoma malaria

Genetic Association Database (GAD): VAMP8
Human Genome Epidemiology (HuGE) Navigator: VAMP8 (12 documents)

Export disorders for VAMP8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for VAMP8 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with VAMP8)

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Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PubMed id 9614193)^{1, 2, 3, 9} Wong S.H.... Hong W. (1998)
Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PubMed id 9878266)^{1, 3, 9} Bui T.D....Hong W. (1998)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. (PubMed id 16110299)^{1, 4} Brinkman J.F....Bergen A.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. (PubMed id 12130530)^{1, 2} Polgar J.... Reed G.L. (2002)
VAMP8/endobrevin is overexpressed in hyperreactive hu man platelets: suggested role for platelet microRNA. (PubMed id 19943878)^{1, 9} Kondkar A.A....Bray P.F. (2010)
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. (PubMed id 18253931)^{1, 9} Sander L.E....Lorentz A. (2008)
Combinational soluble N-ethylmaleimide-sensitive fact or attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antim icrobial and canonical autophagosomes with lysosomes. (PubMed id 20089838)^{1, 9} Furuta N....Amano A. (2010)
Role of VAMP8/endobrevin in constitutive exocytotic p athway in HeLa cells. (PubMed id 19738360)^{1, 9} Okayama M....Takuma T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8673	HGNC: 12647	AceView: VAMP8andVAMP5	Ensembl:ENSG00000118640	euGenes: HUgn8673
ECgene: VAMP8	Kegg: 8673	H-InvDB: VAMP8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for VAMP8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VAMP8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VAMP8 gene:
Search GeneIP for patents involving VAMP8

GeneCards and IP:
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vesicle-associated membrane protein 8

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vesicle-associated membrane protein 8

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