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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP8 Gene

protein-coding   GIFtS: 62
GCID: GC02P085788

Vesicle-Associated Membrane Protein 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vesicle-Associated Membrane Protein 81 2
EDB2 3
VAMP-82 3
endobrevin1
Vesicle-Associated Membrane Protein 8 (Endobrevin)2
Endobrevin3

External Ids:    HGNC: 126471   Entrez Gene: 86732   Ensembl: ENSG000001186407   OMIM: 6031775   UniProtKB: Q9BV403   

Export aliases for VAMP8 gene to outside databases

Previous GC identifers: GC02P085700 GC02P086098 GC02P085779 GC02P085716 GC02P085658 GC02P085701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP8 Gene:
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane
protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded
protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.(provided by RefSeq, Jun
2010)

GeneCards Summary for VAMP8 Gene: 
VAMP8 (vesicle-associated membrane protein 8) is a protein-coding gene. Diseases associated with VAMP8 include primary open angle glaucoma, and open-angle glaucoma, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is VAMP2.

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40
Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in
autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required
for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar
cells. Involved in the abscission of the midbody during cell division, which leads to completely separate
daughter cells. Involved in the homotypic fusion of early and late endosomes

Gene Wiki entry for VAMP8 (Vesicle-associated membrane protein 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP8 gene promoter:
         c-Fos   AP-1   JunB   FosB   Olf-1   JunD   E2F-1   E2F   Msx-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12-p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p12-p11.2

VAMP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085788:  view genomic region     (about GC identifiers)

Start:
85,788,685 bp from pter      End:
85,809,156 bp from pter
Size:
20,472 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 8  
Size: 100 amino acids; 11438 Da
Subunit: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with
lysosome. Binds tightly to multiple syntaxins. Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25,
STX1A, STX4, STX7, STX8 and VTI1B
Subcellular location: Lysosome membrane; Single-pass type IV membrane protein (Probable). Late endosome membrane;
Single-pass type IV membrane protein (Probable). Note=Perinuclear vesicular structures of the early and late
endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody
region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical
but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By
similarity)
Secondary accessions: O60625 Q53SP9 Q6IB09

Explore the universe of human proteins at neXtProt for VAMP8: NX_Q9BV40

Explore proteomics data for VAMP8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BV40

  • VAMP8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VAMP8 Protein Expression
    REFSEQ proteins: NP_003752.2  
    ENSEMBL proteins: 
     ENSP00000407984   ENSP00000263864   ENSP00000387094  
    Reactome Protein details: Q9BV40
    Human Recombinant Protein Products for VAMP8: 
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    Cloud-Clone Corp. Proteins for VAMP8 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005765lysosomal membrane IDA--
    GO:0005769early endosome TAS9614193
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS9614193

    VAMP8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VAMP: Vesicle-associated membrane proteins

    2 InterPro protein domains:
     IPR016444 Synaptobrevin_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry Q9BV40

    ProtoNet protein and cluster: Q9BV40

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP8_HUMAN, Q9BV40
    Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
    for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
    an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in
    autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required
    for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar
    cells. Involved in the abscission of the midbody during cell division, which leads to completely separate
    daughter cells. Involved in the homotypic fusion of early and late endosomes

         Genatlas biochemistry entry for VAMP8:
    vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N
    ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early
    endosome,involved in regulating membrane traffic

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019905syntaxin binding IEA--
         
    VAMP8 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for VAMP8:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vamp8):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  renal/urinary system 

    VAMP8 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidVAMP8 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAMP8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    3Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    4Membrane Trafficking
    Membrane Trafficking0.32
    5wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for VAMP8
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Transport Clathrin-coated vesicle cycle
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

    5        Reactome Pathways for VAMP8
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding
    Lysosome Vesicle Biogenesis

    1 PharmGKB Pathway for VAMP8
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for VAMP8):
        SNARE interactions in vesicular transport


    VAMP8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for VAMP8 (Q9BV402, 3 ENSP000002638644) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX8Q9UNK02, 3, ENSP000003052554MINT-7255609 I2D: score=2 STRING: ENSP00000305255
    STX7O154002, 3, ENSP000003569184MINT-7255609 I2D: score=3 STRING: ENSP00000356918
    STX6O437522, 3, ENSP000002583014MINT-7255609 I2D: score=1 STRING: ENSP00000258301
    STX4Q128463, ENSP000003177144I2D: score=3 STRING: ENSP00000317714
    VAMP2P630273, ENSP000003142144I2D: score=3 STRING: ENSP00000314214
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000046autophagic vacuole fusion IMP--
    GO:0006461protein complex assembly IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006906vesicle fusion IEA--
    GO:0015031protein transport IEA--

    VAMP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAMP8

    Search CenterWatch for drugs/clinical trials and news about VAMP8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAMP8 gene: 
    NM_003761.4  

    Unigene Cluster for VAMP8:

    Vesicle-associated membrane protein 8
    Hs.714302  [show with all ESTs]
    Unigene Representative Sequence: BU199072
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432071 ENST00000263864(uc002spt.4) ENST00000409760
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF053233.1 BC001634.1 BT006700.1 CR456995.1 

    13 DOTS entries:

    DT.75123759  DT.101963601  DT.100861790  DT.95201826  DT.91891588  DT.97780127  DT.121006292  DT.91732827 
    DT.92024796  DT.92431989  DT.95201827  DT.87011100  DT.92431991 

    24/316 AceView cDNA sequences (see all 316):

    AI418592 BM761526 BM707971 CD369345 AA365845 BM767073 AI419209 BI836255 
    AF077197 AA371270 F27921 BM887680 W80846 CB156929 BQ227618 NM_006634 
    BX092149 N90862 BX113655 CR542215 CB108371 AI568721 AI079353 BM702226 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP8    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                                                            
    SP2:                                -                           
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for VAMP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP8 expression in normal human tissues (normalized intensities)      VAMP8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGGGAA
    VAMP8 Expression
    About this image


    VAMP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             hIPS1
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Presumptive Podocytes Podocyte Layer
             Human Renal Mesangial Cells (HRMC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem progenitor RP1-MV2-16
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial progenitor RP1-MV2-18
     
     Epithelium
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   

    See VAMP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAMP8

    SOURCE GeneReport for Unigene cluster: Hs.714302

    UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40
    Tissue specificity: Platelets

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP8 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp81 , 5 vesicle-associated membrane protein 81, 5 85.57(n)1
    89.69(a)1
      6 (32.27 cM)5
    223201  NM_016794.31  NP_058074.21 
     723852235 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP86
    Uncharacterized protein
    64(a)
    1 ↔ 1
    AAWZ02038425(2887-8111)
    zebrafish
    (Danio rerio)
    Actinopterygii vamp81 vesicle-associated membrane protein 8 (endobrevin) 68.58(n)
    68.97(a)
      327007  NM_199759.1  NP_956053.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vamp-86
    vamp-76
    Protein VAMP-7
    34(a)
    13(a)
    1 ↔ many
    1 ↔ many
    IV(13860144-13865294)
    IV(2608049-2610212)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNC16
    SNC26
    Vesicle membrane receptor protein (v-SNARE) involv...
    Vesicle membrane receptor protein (v-SNARE) involv...
    21(a)
    21(a)
    many ↔ many
    many ↔ many
    I(87286-87752)
    XV(930734-931081)


    ENSEMBL Gene Tree for VAMP8 (if available)
    TreeFam Gene Tree for VAMP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP8 gene
    VAMP22  VAMP12  VAMP32  VAMP42  ENSG000002636202  
    6 SIMAP similar genes for VAMP8 using alignment to 3 protein entries:     VAMP8_HUMAN (see all proteins):
    VAMP4    VAMP2    VAMP1    VAMP3    VAMP5    SYBL1

    VAMP8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 SNPs in VAMP8 are shown (see all 135)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563590021,2
    C,F--85666751(+) AAAAGC/TTACAG 1 -- us2k13Minor allele frequency- T:0.11WA NA 240
    rs1454751411,2
    --85666799(+) TGTGGC/TCGGGC 1 -- us2k10--------
    rs1476986091,2
    C--85666800(+) GTGGCC/TGGGCG 1 -- us2k10--------
    rs558926651,2
    C--85666845(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs1501951091,2
    C--85666997(+) AAAATC/TGCTTG 1 -- us2k10--------
    rs1455938671,2
    --85667041(+) TAGCGC/GCATTG 1 -- us2k10--------
    rs2005472461,2
    --85667163(+) GAGGA-/TTACTT 1 -- us2k10--------
    rs1489157551,2
    --85667256(+) ATGGCA/GGTTCG 1 -- us2k10--------
    rs1888903131,2
    --85667265(+) CGCACC/TTGTAG 1 -- us2k10--------
    rs134258211,2
    C,F,A--85667333(+) tgcagG/Tgtgct 1 -- us2k16Minor allele frequency- T:0.11WA NA CSA 246

    HapMap Linkage Disequilibrium report for VAMP8 (85788685 - 85809156 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VAMP8: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VAMP8
    DNA2.0 Custom Variant and Variant Library Synthesis for VAMP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603177    OMIM disorders: --

    13 diseases for VAMP8:    About MalaCards
    primary open angle glaucoma    open-angle glaucoma    glaucoma    coronary heart disease
    kidney disease    myocardial infarction    pancreatic cancer    hypertension
    pancreatitis    melanoma    prostate cancer    prostatitis
    neuronitis


    VAMP8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VAMP8
    Human Genome Epidemiology (HuGE) Navigator: VAMP8 (12 documents)

    Export disorders for VAMP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP8 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with VAMP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PubMed id 9614193)1, 2, 3, 9 Wong S.H.... Hong W. (1998)
    2. Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PubMed id 9878266)1, 3, 9 Bui T.D....Hong W. (1998)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. [Association of the polymorphism of synaptobrevins/ve sicle-associated membrane proteins 8 gene with coronary heart disease in Chines e Han population] (PubMed id 20533276)1, 4 Duan C.C....Chen Q. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    7. Polymorphisms associated with both noncardioembolic s troke and coronary heart disease: vienna stroke registry. (PubMed id 19752551)1, 4 Luke M.M....Mannhalter C. (2009)
    8. Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. (PubMed id 19282863)1, 4 Yoshida T....Yamada Y. (2009)
    9. Five common gene variants identify elevated genetic risk for coronary heart disease. (PubMed id 18073581)1, 4 Bare L.A....Boerwinkle E. (2007)
    10. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. (PubMed id 16690874)1, 4 Shiffman D....Devlin J.J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8673 HGNC: 12647 AceView: VAMP8andVAMP5 Ensembl:ENSG00000118640 euGenes: HUgn8673
    ECgene: VAMP8 Kegg: 8673 H-InvDB: VAMP8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAMP8 gene:
    Search GeneIP for patents involving VAMP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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