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Aliases & Descriptions for VAMP8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EDB 1, 2, 3 | | Endobrevin 3 | | VAMP-8 3 | | endobrevin 2 |
| | | Descriptions |
|---|
| vesicle-associated membrane protein 8 2 | | vesicle-associated membrane protein 8 (endobrevin) 2 |
|
| | Search outside databases for aliases for VAMP8 genePrevious GC identifers: GC02P085700 GC02P086098 GC02P085779 GC02P085716 |
Summaries for VAMP8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAMP8: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex. [provided by RefSeq] UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes (By similarity)Gene Wiki entry for VAMP8 (Vesicle-associated_membrane_protein_8) |
Genomic Location for VAMP8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAMP8 gene 
Entrez Gene cytogenetic band: 2p12-p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p12-p11.2VAMP8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P085658:
(about GC identifiers)
Start:
|
85,658,227 bp from pter |
End:
|
85,662,665 bp from pter |
Size:
|
4,439 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for VAMP8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40 (See
protein sequence)Recommended Name: Vesicle-associated membrane protein 8 Size: 100 amino acids; 11438 Da
Subunit: Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (By similarity). Interacts with STX8 (By similarity)
Subcellular location: Membrane; Single-pass type IV membrane protein (Probable)
Secondary accessions: O60625 Q53SP9 Q6IB09Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003752.2
ENSEMBL proteins: ENSP00000387094 ENSP00000263864
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VAMP8 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VAMP8: Assays for VAMP8: | Protein
Domains/ Families for VAMP8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BV40
ProtoNet protein and cluster: Q9BV40 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40Similarity: Belongs to the synaptobrevin familySimilarity: Contains 1 v-SNARE coiled-coil homology domain | Gene Function for VAMP8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003761
Applied Biosystems Silencer® siRNAs for VAMP8
Sigma-Aldrich siRNA for VAMP8  Sigma-Aldrich shRNA for VAMP8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003761                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003761                                  untagged cDNA clone in CMV expression vector: NM_003761 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003761
UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes (By similarity)Genatlas biochemistry entry for VAMP8:vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early endosome,involved in regulating membrane traffic7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vamp8):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for VAMP8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VAMP8 
5/40 Interacting proteins for VAMP8 (ENSP000002638643) via UniProtKB, MINT, and/or STRING (see all 40
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016192 | vesicle-mediated transport |
IEA | -- | About this table
|
Drugs & Compounds for VAMP8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAMP8
|
Transcripts for VAMP8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003761
Sigma-Aldrich siRNA for VAMP8  Sigma-Aldrich shRNA for VAMP8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003761 REFSEQ mRNAs for VAMP8 gene: NM_003761.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003761               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003761                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003761                                  untagged cDNA clone in CMV expression vector: NM_003761  Additional cDNA sequence: AF053233.1 BC001634.1 BT006700.1 CR456995.1 CR594380.1 13 DOTS entries: DT.75123759 DT.101963601 DT.100861790 DT.95201826 DT.91891588 DT.91732827 DT.97780127 DT.121006292 DT.92024796 DT.92431989 DT.95201827 DT.87011100 DT.92431991 24/316 AceView cDNA sequences (see all 316
):N90862 CR542215 AA361428 AA365845 W80846 AA309787 BM761526 AA371270 BM767073 AI419209 AA305331 BQ021316 AA634593 AA836089 BM702226 AI079353 NM_006634 BQ675243 BX092149 CR594380 BI836255 CB108371 BQ227618 BM887680
highest scoring ESTs for VAMP8:AF053233 AI087923 AA165027 AA299296 AA467782 AA469453 AA526368 AA577146 AA630775 AA677095 Unigene Cluster for VAMP8: Vesicle-associated membrane protein 8 (endobrevin) Hs.714302 [show with all ESTs]Unigene Representative Sequence: BU199072
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAMP8
2 Ensembl transcripts including schematic representations: ENST00000409760
ENST00000263864
|
Expression for VAMP8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAMP8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAMP8
1 / 2 / 3 4 probe-sets matching VAMP8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGCTGGGAA
SOURCE GeneReport for Unigene cluster: Hs.714302
Expression variation in blood from EXPOLDB for VAMP8 UniProtKB/Swiss-Prot: VAMP8_HUMAN, Q9BV40Tissue specificity: Platelets |
Orthologs for VAMP8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAMP8 gene from 5 species
About this table Species with no ortholog for VAMP8
ENSEMBL Gene Tree for VAMP8 | Paralogs for VAMP8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAMP8 gene
- VAMP52 VAMP42
|
SNPs/Variants for VAMP8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAMP8 (up to first 250kb)
|
Disorders & Mutations for VAMP8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603177
Genetic Association Database: VAMP8 Human Genome Epidemiology Navigator: VAMP8 (6 documents)
|
Medical News for VAMP8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAMP8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/41 PubMed articles for VAMP8 gene (see all 41
):- Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PubMed id 9614193)1, 2, 3, 4 Wong S.H....Hong W. (1998)
- Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PubMed id 9878266)1, 2, 3 Bui T.D....Hong W. (1998)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. (PubMed id 16110299)3, 6 Brinkman J.F....Bergen A.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. (PubMed id 12130530)3, 4 Polgar J.... Reed G.L. (2002)
- Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. (PubMed id 18253931)1, 3 Sander L.E....Lorentz A. (2008)
- Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PubMed id 18570918)1, 3 Bilan F....Thoreau V. (2008)
- Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. (PubMed id 16195891)1, 3 Oishi Y....Takuma T. (2006)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)3 Luke M.M....Psaty B.M. (2009)
|
Search for VAMP8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAMP8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAMP8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAMP8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAMP8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAMP8:

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Incremental update: 13 Oct 2009
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