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Aliases for VAMP8 Gene

Aliases for VAMP8 Gene

  • Vesicle Associated Membrane Protein 8 2 3 5
  • Endobrevin 2 4
  • VAMP-8 3 4
  • EDB 3 4
  • Vesicle-Associated Membrane Protein 8 (Endobrevin) 3

External Ids for VAMP8 Gene

Previous GeneCards Identifiers for VAMP8 Gene

  • GC02P085700
  • GC02P086098
  • GC02P085779
  • GC02P085716
  • GC02P085658
  • GC02P085788
  • GC02P085701

Summaries for VAMP8 Gene

Entrez Gene Summary for VAMP8 Gene

  • This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

GeneCards Summary for VAMP8 Gene

VAMP8 (Vesicle Associated Membrane Protein 8) is a Protein Coding gene. Among its related pathways are Platelet activation and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP8 Gene

  • SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).

Gene Wiki entry for VAMP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP8 Gene

Genomics for VAMP8 Gene

Regulatory Elements for VAMP8 Gene

Enhancers for VAMP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VAMP8 on UCSC Golden Path with GeneCards custom track

Promoters for VAMP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAMP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAMP8 Gene

Chromosome:
2
Start:
85,561,562 bp from pter
End:
85,582,033 bp from pter
Size:
20,472 bases
Orientation:
Plus strand

Genomic View for VAMP8 Gene

Genes around VAMP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP8 Gene

Proteins for VAMP8 Gene

  • Protein details for VAMP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV40-VAMP8_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 8
    Protein Accession:
    Q9BV40
    Secondary Accessions:
    • O60625
    • Q53SP9
    • Q6IB09

    Protein attributes for VAMP8 Gene

    Size:
    100 amino acids
    Molecular mass:
    11438 Da
    Quaternary structure:
    • Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:25686604). Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (PubMed:12130530).

    Three dimensional structures from OCA and Proteopedia for VAMP8 Gene

neXtProt entry for VAMP8 Gene

Proteomics data for VAMP8 Gene at MOPED

Post-translational modifications for VAMP8 Gene

  • Ubiquitination at Lys 24, Lys 59, and Lys 64
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAMP8 (VAMP8)

No data available for DME Specific Peptides for VAMP8 Gene

Domains & Families for VAMP8 Gene

Gene Families for VAMP8 Gene

Protein Domains for VAMP8 Gene

Suggested Antigen Peptide Sequences for VAMP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV40

UniProtKB/Swiss-Prot:

VAMP8_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP8: view

Function for VAMP8 Gene

Molecular function for VAMP8 Gene

GENATLAS Biochemistry:
vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early endosome,involved in regulating membrane traffic
UniProtKB/Swiss-Prot Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).

Gene Ontology (GO) - Molecular Function for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with VAMP8: view
genes like me logo Genes that share phenotypes with VAMP8: view

Animal Models for VAMP8 Gene

MGI Knock Outs for VAMP8:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP8 Gene

Localization for VAMP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP8 Gene

Lysosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250 UniProtKB:Q9WUF4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP8 Gene COMPARTMENTS Subcellular localization image for VAMP8 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
mitochondrion 3
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 23217709
GO:0005769 early endosome TAS 9614193
GO:0005829 cytosol IDA 22589474
GO:0005886 plasma membrane TAS --
GO:0031902 late endosome membrane IDA 23217709
genes like me logo Genes that share ontologies with VAMP8: view

Pathways & Interactions for VAMP8 Gene

genes like me logo Genes that share pathways with VAMP8: view

Gene Ontology (GO) - Biological Process for VAMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0046718 viral entry into host cell IMP 24550300
GO:0061024 membrane organization TAS --
GO:0070254 mucus secretion IMP 22144578
genes like me logo Genes that share ontologies with VAMP8: view

No data available for SIGNOR curated interactions for VAMP8 Gene

Drugs & Compounds for VAMP8 Gene

No Compound Related Data Available

Transcripts for VAMP8 Gene

mRNA/cDNA for VAMP8 Gene

Unigene Clusters for VAMP8 Gene

Vesicle-associated membrane protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for VAMP8 Gene

GeneLoc Exon Structure for
VAMP8
ECgene alternative splicing isoforms for
VAMP8

Expression for VAMP8 Gene

mRNA expression in normal human tissues for VAMP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAMP8 Gene

This gene is overexpressed in Nasal epithelium (17.5), Monocytes (8.0), Peripheral blood mononuclear cells (7.9), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP8 Gene



SOURCE GeneReport for Unigene cluster for VAMP8 Gene Hs.714302

mRNA Expression by UniProt/SwissProt for VAMP8 Gene

Q9BV40-VAMP8_HUMAN
Tissue specificity: Platelets.
genes like me logo Genes that share expression patterns with VAMP8: view

Protein tissue co-expression partners for VAMP8 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for VAMP8 Gene

Orthologs for VAMP8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAMP8 35
  • 87.41 (n)
  • 92.86 (a)
VAMP8 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAMP8 35
  • 91.33 (n)
  • 94 (a)
VAMP8 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp8 35
  • 84.67 (n)
  • 87 (a)
Vamp8 16
Vamp8 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP8 35
  • 99.33 (n)
  • 100 (a)
VAMP8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp8 35
  • 84.01 (n)
  • 86.73 (a)
oppossum
(Monodelphis domestica)
Mammalia VAMP8 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP8 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp8 35
  • 71 (n)
  • 70 (a)
zebrafish
(Danio rerio)
Actinopterygii vamp8 35
  • 67.41 (n)
  • 66.67 (a)
vamp8 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vamp-7 36
  • 13 (a)
OneToMany
vamp-8 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 21 (a)
ManyToMany
SNC2 36
  • 21 (a)
ManyToMany
Species with no ortholog for VAMP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP8 Gene

ENSEMBL:
Gene Tree for VAMP8 (if available)
TreeFam:
Gene Tree for VAMP8 (if available)

Paralogs for VAMP8 Gene

Paralogs for VAMP8 Gene

(6) SIMAP similar genes for VAMP8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VAMP8: view

Variants for VAMP8 Gene

Sequence variations from dbSNP and Humsavar for VAMP8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1972297 -- 85,581,450(-) ctgtc(A/G)ctcag intron-variant
rs1058588 -- 85,581,748(+) CTTCT(C/T)TTCAG utr-variant-3-prime
rs1058615 -- 85,581,908(+) AAAAA(A/G)AGAGA utr-variant-3-prime
rs3731827 -- 85,578,945(+) CCAGA(C/T)CTCTG intron-variant
rs3731828 -- 85,579,143(+) CGCAA(C/T)AAGAC reference, synonymous-codon

Variation tolerance for VAMP8 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for VAMP8 Gene

Disorders for VAMP8 Gene

Relevant External Links for VAMP8

Genetic Association Database (GAD)
VAMP8
Human Genome Epidemiology (HuGE) Navigator
VAMP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP8

No disorders were found for VAMP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAMP8 Gene

Publications for VAMP8 Gene

  1. Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PMID: 9614193) Wong S.H. … Hong W. (Mol. Biol. Cell 1998) 2 3 4 23 67
  2. Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PMID: 9878266) Bui T.D. … Hong W. (Genomics 1998) 2 3 23
  3. VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA. (PMID: 19943878) Kondkar A.A. … Bray P.F. (J. Thromb. Haemost. 2010) 3 23
  4. Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. (PMID: 20089838) Furuta N. … Amano A. (Mol. Biol. Cell 2010) 3 23
  5. Role of VAMP8/endobrevin in constitutive exocytotic pathway in HeLa cells. (PMID: 19738360) Okayama M. … Takuma T. (Cell Struct. Funct. 2009) 3 23

Products for VAMP8 Gene

Sources for VAMP8 Gene

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