Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VAMP7 Gene

Aliases for VAMP7 Gene

  • Vesicle-Associated Membrane Protein 7 2 3
  • SYBL1 3 4 6
  • Synaptobrevin-Like Protein 1 3 4
  • Tetanus-Insensitive VAMP 3 4
  • Synaptobrevin-Like 1 2 3
  • TI-VAMP 3 4
  • TIVAMP 3 6
  • VAMP-7 3 4
  • Tetanus Neurotoxin-Insensitive VAMP 3

External Ids for VAMP7 Gene

Previous HGNC Symbols for VAMP7 Gene

  • SYBL1

Previous GeneCards Identifiers for VAMP7 Gene

  • GC0XP154764
  • GC0XP155110
  • GC0XP143593

Summaries for VAMP7 Gene

Entrez Gene Summary for VAMP7 Gene

  • This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for VAMP7 Gene

VAMP7 (Vesicle-Associated Membrane Protein 7) is a Protein Coding gene. Diseases associated with VAMP7 include tetanus and 46,xy partial gonadal dysgenesis. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding.

UniProtKB/Swiss-Prot for VAMP7 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Gene Wiki entry for VAMP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP7 Gene

Genomics for VAMP7 Gene

Regulatory Elements for VAMP7 Gene

Genomic Location for VAMP7 Gene

Start:
155,881,280 bp from pter
End:
155,943,769 bp from pter
Size:
62,490 bases
Orientation:
Plus strand

Genomic View for VAMP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP7 Gene

Proteins for VAMP7 Gene

  • Protein details for VAMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51809-VAMP7_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 7
    Protein Accession:
    P51809
    Secondary Accessions:
    • Q53GY7
    • Q7Z409
    • Q9H4A7

    Protein attributes for VAMP7 Gene

    Size:
    220 amino acids
    Molecular mass:
    24935 Da
    Quaternary structure:
    • Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity).
    Miscellaneous:
    • Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells
    • The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes
    SequenceCaution:
    • Sequence=BI547528; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VAMP7 Gene

    Alternative splice isoforms for VAMP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAMP7 Gene

Proteomics data for VAMP7 Gene at MOPED

Post-translational modifications for VAMP7 Gene

  • Ubiquitination at Lys125, Lys137, Lys160, and Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP7 Gene

Domains for VAMP7 Gene

Gene Families for VAMP7 Gene

HGNC:
  • PAR2 :Pseudoautosomal regions / PAR2
  • VAMP :Vesicle-associated membrane proteins

Protein Domains for VAMP7 Gene

Suggested Antigen Peptide Sequences for VAMP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51809

UniProtKB/Swiss-Prot:

VAMP7_HUMAN :
  • P51809
Domain:
  • Contains 1 longin domain.
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP7: view

Function for VAMP7 Gene

Molecular function for VAMP7 Gene

UniProtKB/Swiss-Prot Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Gene Ontology (GO) - Molecular Function for VAMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 16354670
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with VAMP7: view

miRNA for VAMP7 Gene

miRTarBase miRNAs that target VAMP7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VAMP7 Gene

Localization for VAMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP7 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP7 Gene COMPARTMENTS Subcellular localization image for VAMP7 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 4
cytosol 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VAMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane TAS --
GO:0005789 endoplasmic reticulum membrane ISS 16495485
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IDA 19745841
genes like me logo Genes that share ontologies with VAMP7: view

Pathways for VAMP7 Gene

genes like me logo Genes that share pathways with VAMP7: view

Pathways by source for VAMP7 Gene

Gene Ontology (GO) - Biological Process for VAMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000046 NOT autophagic vacuole fusion IMP 23217709
GO:0006810 transport --
GO:0006887 exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport ISS 16495485
GO:0006892 post-Golgi vesicle-mediated transport TAS --
genes like me logo Genes that share ontologies with VAMP7: view

Compounds for VAMP7 Gene

(1) HMDB Compounds for VAMP7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for VAMP7 Gene

Compound -log(P) Hits PubMed IDs
sulfamethoxypyridazine 84.5 3
genes like me logo Genes that share compounds with VAMP7: view

Transcripts for VAMP7 Gene

Unigene Clusters for VAMP7 Gene

Vesicle-associated membrane protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for VAMP7 Gene

GeneLoc Exon Structure for
VAMP7
ECgene alternative splicing isoforms for
VAMP7

Expression for VAMP7 Gene

mRNA expression in normal human tissues for VAMP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP7 Gene

SOURCE GeneReport for Unigene cluster for VAMP7 Gene Hs.24167

mRNA Expression by UniProt/SwissProt for VAMP7 Gene

P51809-VAMP7_HUMAN
Tissue specificity: Detected in all tissues tested
genes like me logo Genes that share expressions with VAMP7: view

No data available for mRNA differential expression in normal tissues for VAMP7 Gene

Orthologs for VAMP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VAMP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP7 35
  • 94.04 (n)
  • 93.68 (a)
VAMP7 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP7 35
  • 94.85 (n)
  • 98.64 (a)
dog
(Canis familiaris)
Mammalia VAMP7 35
  • 95.61 (n)
  • 99.09 (a)
VAMP7 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp7 35
  • 92.88 (n)
  • 97.27 (a)
Vamp7 36
  • 68 (a)
OneToOne
MGI:1096399 16
oppossum
(Monodelphis domestica)
Mammalia VAMP7 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP7 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp7 35
  • 86.52 (n)
  • 95 (a)
chicken
(Gallus gallus)
Aves VAMP7 35
  • 84.7 (n)
  • 94.09 (a)
VAMP7 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP7 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9516 35
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp7 35
  • 78.48 (n)
  • 92.27 (a)
zebrafish
(Danio rerio)
Actinopterygii sybl1 35
  • 72.6 (n)
  • 85.62 (a)
sybl1 36
  • 60 (a)
OneToOne
zgc56506 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000700 35
  • 55.35 (n)
  • 52.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1599 35
  • 54.59 (n)
  • 52.29 (a)
CG1599 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons VAMP714 35
  • 51.61 (n)
  • 41.94 (a)
rice
(Oryza sativa)
Liliopsida Os10g0154000 35
  • 48.23 (n)
  • 41.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for VAMP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAMP7 Gene

ENSEMBL:
Gene Tree for VAMP7 (if available)
TreeFam:
Gene Tree for VAMP7 (if available)

Paralogs for VAMP7 Gene

Selected SIMAP similar genes for VAMP7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VAMP7: view

No data available for Paralogs for VAMP7 Gene

Variants for VAMP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for VAMP7 Gene

Variant ID Type Subtype PubMed ID
esv2657377 CNV Deletion 23128226
dgv1407e199 CNV Deletion 23128226
nsv10001 CNV Gain 18304495
nsv10043 CNV Gain 18304495

Relevant External Links for VAMP7 Gene

HapMap Linkage Disequilibrium report
VAMP7
Human Gene Mutation Database (HGMD)
VAMP7
Locus Specific Mutation Databases (LSDB)
VAMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for VAMP7 Gene

Disorders for VAMP7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for VAMP7 Gene including...

Search for VAMP7 Gene in MalaCards »

(2) Novoseek inferred disease relationships for VAMP7 Gene

Disease -log(P) Hits PubMed IDs
icf syndrome 82.4 1
tetanus 73.2 10

Relevant External Links for VAMP7

Human Genome Epidemiology (HuGE) Navigator
VAMP7
genes like me logo Genes that share disorders with VAMP7: view

No data available for UniProtKB/Swiss-Prot for VAMP7 Gene

Publications for VAMP7 Gene

  1. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. (PMID: 8640232) D'Esposito M. … D'Urso M. (Nat. Genet. 1996) 2 3 4
  2. A dual mechanism controlling the localization and function of exocytic v-SNARE. (PMID: 12853575) Martinez-Arca S. … Galli T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. (PMID: 11440841) Filippini F. … D'Esposito M. (Trends Biochem. Sci. 2001) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. (PMID: 16677249) Logan M.R. … Moqbel R. (Allergy 2006) 3 4

Products for VAMP7 Gene

  • Addgene plasmids for VAMP7

Sources for VAMP7 Gene

Back to Top

Content