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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP7 Gene

protein-coding   GIFtS: 63
GCID: GC0XP155110

Vesicle-Associated Membrane Protein 7

(Previous name: synaptobrevin-like 1)
(Previous symbol: SYBL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vesicle-Associated Membrane Protein 71 2     VAMP-72 3
SYBL11 2 3 5     TIVAMP2 5
Synaptobrevin-Like 11 2     TI-VAMP2
Synaptobrevin-Like Protein 12 3     Tetanus Neurotoxin-Insensitive VAMP2
Tetanus-Insensitive VAMP2 3     Ti-VAMP3

External Ids:    HGNC: 114861   Entrez Gene: 68452   Ensembl: ENSG000001243337   OMIM: 3000535   UniProtKB: P518093   
ORGUL members:         
NONCODE14:n409350      

Export aliases for VAMP7 gene to outside databases

Previous GC identifers: GC0XP154764 GC0XP143593


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP7 Gene:
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor
attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is
involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Jun 2010)

GeneCards Summary for VAMP7 Gene: 
VAMP7 (vesicle-associated membrane protein 7) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with VAMP7 include tetanus, and rett syndrome, and among its related super-pathways are Clathrin derived vesicle budding and Clathrin-dependent protein traffic. GO annotations related to this gene include protein binding and syntaxin binding.

UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport
of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with
lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the
export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators
during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for
focal exocytosis of late endocytic vesicles during phagosome formation

Gene Wiki entry for VAMP7 (SYBL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.2  NT_167198.1  NT_167206.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP7 gene promoter:
         AREB6   C/EBPbeta   Nkx2-5   Meis-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 and Yq12   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28 and Yq12

VAMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP155110:  view genomic region     (about GC identifiers)

Start:
155,110,943 bp from pter      End:
155,173,433 bp from pter
Size:
62,491 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 59,213,949-59,276,439     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 7  
Size: 220 amino acids; 24935 Da
Subunit: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal
exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for
heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein (By
similarity). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (By similarity).
Late endosome membrane; Single-pass type IV membrane protein (By similarity). Lysosome membrane; Single-pass type
IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity).
Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein (By similarity). Cell junction,
synapse, synaptosome (By similarity). Note=In immature neurons expression is localized in vesicular structures in
axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1
in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in
liver or kidney (By similarity)
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y
chromosomes
Miscellaneous: Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell
killing by natural killer cells
Sequence caution: Sequence=BI547528; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the
C-terminal part;
1 PDB 3D structure from and Proteopedia for VAMP7:
2DMW (3D)    
Secondary accessions: Q53GY7 Q7Z409 Q9H4A7
Alternative splicing: 3 isoforms:  P51809-1   P51809-2   P51809-3   

Explore the universe of human proteins at neXtProt for VAMP7: NX_P51809

Explore proteomics data for VAMP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51809

  • VAMP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VAMP7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138621.1  NP_001172112.1  NP_005629.1  

    ENSEMBL proteins: 
     ENSP00000286448   ENSP00000430039   ENSP00000262640   ENSP00000427822  
    Reactome Protein details: P51809
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    Cloud-Clone Corp. Proteins for VAMP7 

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005765lysosomal membrane TAS--
    GO:0005789endoplasmic reticulum membrane ISS16495485
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--

    VAMP7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PAR2: Pseudoautosomal regions / PAR2
    VAMP: Vesicle-associated membrane proteins

    3 InterPro protein domains:
     IPR010908 Longin_dom
     IPR001388 Synaptobrevin
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry P51809

    ProtoNet protein and cluster: P51809

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP7_HUMAN, P51809
    Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport
    of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with
    lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the
    export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators
    during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for
    focal exocytosis of late endocytic vesicles during phagosome formation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16354670
    GO:0019905syntaxin binding IEA--
         
    VAMP7 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAMP7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    2Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40
    4Membrane Trafficking
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for VAMP7
        Transport Clathrin-coated vesicle cycle

    5        Reactome Pathways for VAMP7
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding
    Lysosome Vesicle Biogenesis


    1         Kegg Pathway  (Kegg details for VAMP7):
        SNARE interactions in vesicular transport


    VAMP7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for VAMP7 (P518091, 2, 3 ENSP000002864484) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGFG1P525941, 3EBI-1052205,EBI-996560 I2D: score=1 
    STX7O154002, 3, ENSP000003569184MINT-7255549 I2D: score=2 STRING: ENSP00000356918
    ANKRD27Q96NW42, 3, ENSP000003042924MINT-7293235 I2D: score=1 STRING: ENSP00000304292
    AP3D1O146173, ENSP000003440554I2D: score=6 STRING: ENSP00000344055
    DNAJC13O751653, ENSP000002608184I2D: score=2 STRING: ENSP00000260818
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000046NOT autophagic vacuole fusion IMP--
    GO:0006810transport ----
    GO:0006888ER to Golgi vesicle-mediated transport ISS16495485
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006906vesicle fusion IDA10888671

    VAMP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAMP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for VAMP7

    1 HMDB Compound for VAMP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for VAMP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfamethoxypyridazine 84.5 7 15544955 (2), 18775314 (1)

    Search CenterWatch for drugs/clinical trials and news about VAMP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAMP7 gene (3 alternative transcripts): 
    NM_001145149.2  NM_001185183.1  NM_005638.5  

    Unigene Cluster for VAMP7:

    Vesicle-associated membrane protein 7
    Hs.24167  [show with all ESTs]
    Unigene Representative Sequence: BC056141
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286448(uc011naa.2 uc004fnr.3 uc011nab.2 uc004fnt.3 uc004fns.3 uc011nac.2)
    ENST00000479687 ENST00000488344 ENST00000463317 ENST00000262640 ENST00000460621

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AJ295938.1 AJ549301.2 AK222794.1 AK293525.1 AK295605.1 AK312658.1 BC056141.1 NR_033714.1 
    NR_033715.1 X92396.1 

    23 DOTS entries:

    DT.100650163  DT.416737  DT.97855551  DT.91661651  DT.121314006  DT.100725352  DT.120654130  DT.121314010 
    DT.121314011  DT.121314013  DT.92432660  DT.95123613  DT.100657127  DT.120654098  DT.100805541  DT.120654148 
    DT.121314001  DT.95112539  DT.97855552  DT.100641005  DT.100650162  DT.120654177  DT.121314000 

    24/231 AceView cDNA sequences (see all 231):

    CB266579 AA854952 BQ431803 CA867457 AA565995 BE893202 CA311686 BQ023051 
    BG292269 AJ549301 AI476446 AW673122 AI937505 AA187590 AI146794 AA622708 
    AI522002 AU131023 CK905692 BM750303 BM904257 CA867530 AA838476 BP341618 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                            
    SP2:                                      -                     


    ECgene alternative splicing isoforms for VAMP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP7 expression in normal human tissues (normalized intensities)      VAMP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCATTTTA
    VAMP7 Expression
    About this image


    VAMP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See VAMP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAMP7

    SOURCE GeneReport for Unigene cluster: Hs.24167

    UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
    Tissue specificity: Detected in all tissues tested

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VAMP7 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp71 vesicle-associated membrane protein 7 92.88(n)
    97.27(a)
      20955  NM_011515.4  NP_035645.1 
    chicken
    (Gallus gallus)
    Aves VAMP71 vesicle-associated membrane protein 7 84.7(n)
    94.09(a)
      422297  NM_001031121.1  NP_001026292.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP76
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343202.1(1804475-1809245)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.95162 Xenopus laevis transcribed sequence with strong similarity more 79.86(n)    BU916994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565062 similar to synaptobrevin-like 1 72.63(n)   393236  BC049034.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15991 CG1599 54.59(n)
    52.29(a)
      36015  NM_136680.3  NP_610524.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VAMP7141 vesicle-associated membrane protein 714 51.61(n)
    41.94(a)
      832297  NM_122141.4  NP_197628.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g01540001 hypothetical protein 48.23(n)
    41.01(a)
      4348130  NM_001070719.1  NP_001064184.1 


    ENSEMBL Gene Tree for VAMP7 (if available)
    TreeFam Gene Tree for VAMP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP7 gene
    2 SIMAP similar genes for VAMP7 using alignment to 2 protein entries:     VAMP7_HUMAN (see all proteins):
    SYBL1    VAMP4

    VAMP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VAMP7:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1407e199CNV Deletion23128226
    esv2657377CNV Deletion23128226
    nsv10001CNV Gain18304495
    nsv10043CNV Gain18304495


    Human Gene Mutation Database (HGMD): VAMP7

    Locus Specific Mutation Databases (LSDB): VAMP7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VAMP7
    DNA2.0 Custom Variant and Variant Library Synthesis for VAMP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300053    OMIM disorders: --

    9 diseases for VAMP7:    About MalaCards
    tetanus    rett syndrome    klinefelter's syndrome    chronic myeloid leukemia
    bipolar disorder    myeloid leukemia    melanoma    leukemia
    neuronitis


    VAMP7 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for VAMP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    icf syndrome 82.4 1 12444103 (1)
    tetanus 73.2 16 10811829 (2), 17335083 (1), 19576189 (1), 9614185 (1) (see all 9)

    Human Genome Epidemiology (HuGE) Navigator: VAMP7 (1 document)

    Export disorders for VAMP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP7 gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with VAMP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. (PubMed id 8640232)1, 2, 3 D'Esposito M.... D'Urso M. (1996)
    2. Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. (PubMed id 18042464)1, 2 Marcet-Palacios M.... Moqbel R. (2008)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A dual mechansim controlling the localization and function of exocytic v-SNARE. (PubMed id 12853575)1, 2 Martinez-Arca S.... Galli T. (2003)
    6. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. (PubMed id 11440841)1, 3 Filippini F....D'Esposito M. (2001)
    7. Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. (PubMed id 10888671)1, 2 Ward D.M.... Kaplan J. (2000)
    8. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (2000)
    9. Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements. (PubMed id 14672948)1, 9 Di Leva F....Franze A. (2004)
    10. VAMP-7 mediates vesicular transport from endosomes to lysosomes. (PubMed id 10459012)1, 9 Advani R.J....Scheller R.H. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6845 HGNC: 11486 AceView: SYBL1.1 Ensembl:ENSG00000124333 euGenes: HUgn6845
    ECgene: VAMP7 Kegg: 6845 H-InvDB: VAMP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAMP7 gene:
    Search GeneIP for patents involving VAMP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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