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VAMP7 Gene

protein-coding   GIFtS: 51

GC0XP154764
vesicle-associated membrane protein 7
(Previous name: synaptobrevin-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SYBL1)
Services    

Aliases &
Descriptions
for VAMP7

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000024259 2
SYBL1 2, 3
TI-VAMP 1, 2
Ti-VAMP 3
VAMP-7 1, 2, 3
Descriptions
Synaptobrevin-like protein 1 3
Tetanus-insensitive VAMP 3
synaptobrevin-like 1 1, 2
tetanus insensitive VAMP (Ti-VAMP) 2
vesicle-associated membrane protein 7 2
External Ids
HGNC: 114861
Entrez Gene: 68452
UniProtKB: P518093
Ensembl: ENSG000001243337
Search outside databases for aliases for VAMP7 gene

Summaries
for VAMP7

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane
during transport of proteins from the early endosome to the lysosome. Required for heterotypic
fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium
regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic
reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil
degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of
late endocytic vesicles during phagosome formation

Gene Wiki entry for VAMP7 (SYBL1)

Genomic Location
for VAMP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 and Yq12   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28 and Yq12

VAMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154764:     (about GC identifiers)

Start:
 154,764,207 bp from pter
End:
 154,826,614 bp from pter
Size:
 62,408 bases
Orientation:
 plus strand

1 alternative location:
ChrY+ 57,623,407-57,685,814     
RefSeq DNA sequence:
NC_000023.9  NC_000024.8  NT_011726.13  NT_113974.1  

Proteins
for VAMP7

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 7  
Size: 220 amino acids; 24935 Da
Subunit: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during
lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that
is required for heterotypic fusion of late endosomes with lysosomes in liver cells (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane
protein (By similarity). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV
membrane protein (By similarity). Late endosome membrane; Single-pass type IV membrane protein (By
similarity). Lysosome membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic
reticulum membrane; Single-pass type IV membrane protein (By similarity). Cytoplasmic vesicle,
phagosome membrane; Single-pass type IV membrane protein (By similarity)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2)
of X and Y chromosomes
Miscellaneous: Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release
and target cell killing by natural killer cells
PDB structure from and Proteopedia :
2DMW (3D)    2VX8 (3D)    
Secondary accessions: Q53GY7 Q7Z409 Q9H4A7
Alternative splicing: 3 isoforms:  P51809-1   P51809-2   P51809-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001138621.1  NP_005629.1  


    ENSEMBL proteins: 
    ENSP00000262640 ENSP00000358435 ENSP00000286448 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SYBL1)
    Human Recombinant Proteins from Abnova (VAMP7)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/12 Gene Ontology (GO) cellular component terms (links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765 lysosomal membrane ISS10459012
    GO:0005768 endosome IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane ISS16495485
    GO:0005794 Golgi apparatus IEA--
    About this table

    Antibodies for VAMP7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SYBL1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (VAMP7)
    Novus Biologicals Antibodies for VAMP7

    Assays for VAMP7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for VAMP7

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR010908 Longin
     IPR001388 Synaptobrevin


       GeneDecks  VAMP7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P51809

    ProtoNet protein and cluster: P51809

    1 Blocks protein family: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain
    Similarity: Contains 1 v-SNARE coiled-coil homology domain

    Gene Function
    for VAMP7

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (VAMP7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (VAMP7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145149

                  Applied Biosystems Silencer® siRNAs for VAMP7

                  Sigma-Aldrich siRNA for VAMP7  
                         Sigma-Aldrich shRNA for VAMP7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for VAMP7
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145149
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145149
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145149 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005638

    UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
    Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane
    during transport of proteins from the early endosome to the lysosome. Required for heterotypic
    fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium
    regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic
    reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil
    degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of
    late endocytic vesicles during phagosome formation

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding ISS14993220
    About this table

    Pathways & Interactions
    for VAMP7

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for VAMP7):
     hsa04130 SNARE interactions in vesicular transport

       GeneDecks  VAMP7 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  VAMP7 


    1 Interacting protein for VAMP7 (P518091) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGFG1P525941EBI-1052205, EBI-996560
    About this table

    5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888 ER to Golgi vesicle-mediated transport ISS16495485
    GO:0006906 vesicle fusion IDA10888671
    GO:0006911 phagocytosis, engulfment ISS15133481
    GO:0008333 endosome to lysosome transport IDA10888671
    GO:0015031 protein transport IEA--
    About this table

    Drugs & Compounds
    for VAMP7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VAMP7

    Transcripts
    for VAMP7

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (VAMP7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (VAMP7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145149

                  Sigma-Aldrich siRNA for VAMP7  
                         Sigma-Aldrich shRNA for VAMP7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005638  

    REFSEQ mRNAs for VAMP7 gene (2 alternative transcripts): 

    NM_001145149.1   NM_005638.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005638  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145149
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145149
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145149 

    Additional cDNA sequence: 

    AJ295938.1 AJ549301.2 AK222794.1 AK312658.1 BC056141.1 CR604175.1 CR609740.1 X92396.1 

    21 DOTS entries:

    DT.100650163  DT.416737  DT.97855551  DT.91661651  DT.121314006  DT.100725352  DT.120654130  DT.121314010 
    DT.121314011  DT.121314013  DT.92432660  DT.95123613  DT.100805541  DT.120654148  DT.121314001  DT.95112539 
    DT.97855552  DT.100641005  DT.100650162  DT.120654177  DT.121314000 

    24/231 AceView cDNA sequences (see all 231 ):

    BQ027412 CA311686 AI476446 AI522002 AW673122 BM783745 CA867457 AA565995 
    AW296334 CR604175 AI262079 AI202446 AJ549301 AA622708 CR609740 AA187590 
    AU135914 F07813 BQ921634 AW474256 AW292016 Z40908 BP341618 F05522 

    Unigene Cluster for VAMP7:

    Vesicle-associated membrane protein 7
    Hs.24167  [show with all ESTs]
    Unigene Representative Sequence: BC056141


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP7

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                            
    SP2:                                      -                     

    About this scheme

    ECgene alternative splicing isoforms for VAMP7

    3 Ensembl transcripts including schematic representations:
    ENST00000262640  ENST00000369427  ENST00000286448  

    Expression
    for VAMP7

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VAMP7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VAMP7

    1 / 2

    3 probe-sets matching VAMP7 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		34753_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

    		202829_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		202829_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCTCATTTTA

    SOURCE GeneReport for Unigene cluster: Hs.24167

    UniProtKB/Swiss-Prot: VAMP7_HUMAN, P51809
    Tissue specificity: Detected in all tissues tested

    Orthologs
    for VAMP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for VAMP7 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 VAMP71   -- vesicle-associated membrane protein 7 95.61(n)
    99.09(a)    		 612663  XM_850396.1  XP_855489.1 
    cow
    (Bos taurus)    		 VAMP71   -- vesicle-associated membrane protein 7 94.85(n)
    98.64(a)    		 613984  NM_001076302.1  NP_001069770.1 
    rat
    (Rattus norvegicus)    		 Vamp71   -- vesicle-associated membrane protein 7 86.52(n)
    95(a)    		 85491  NM_053531.1  NP_445983.1 
    mouse
    (Mus musculus)    		 Vamp71   -- vesicle-associated membrane protein 7 92.88(n)
    97.27(a)    		 20955  NM_011515.2  NP_035645.1 
    chicken
    (Gallus gallus)    		 SYBL11   -- synaptobrevin-like 1 85.03(n)
    95.81(a)    		 422297  XM_001233576.1  XP_001233577.1 
    About this table        Species with no ortholog for VAMP7

    ENSEMBL Gene Tree for VAMP7

    Paralogs
    for VAMP7

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for VAMP7

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for VAMP7

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 300053

    2 Novoseek disease relationships for VAMP7 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    icf syndrome 82.98 1 12444103 (1)
    tetanus 70.66 15 10811829 (2), 17335083 (1), 11356871 (1), 14517330 (1) (see all 8)
    About this table

    Human Genome Epidemiology Navigator: VAMP7 (1 document)

    Medical News
    for VAMP7

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for VAMP7

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/65 PubMed articles for VAMP7 gene (see all 65 ):

    Search for VAMP7

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VAMP7

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6845 HGNC: 11486 AceView: SYBL1.1 Ensembl:ENSG00000124333 euGenes: HUgn6845
    ECgene: VAMP7 H-InvDB: VAMP7

    Other Databases showing VAMP7

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing VAMP7

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for VAMP7

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for VAMP7

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VAMP7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VAMP7-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for VAMP7 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VAMP7 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (VAMP7)
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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (SYBL1)
     Antibodies (SYBL1)
     Search OriGene for VAMP7
     Search Tocris compounds for VAMP7




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for VAMP7

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