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Aliases for VAMP5 Gene

Aliases for VAMP5 Gene

  • Vesicle Associated Membrane Protein 5 2 3 5
  • Myobrevin 2 3 4
  • VAMP-5 3 4
  • Vesicle-Associated Membrane Protein 5 3

External Ids for VAMP5 Gene

Previous GeneCards Identifiers for VAMP5 Gene

  • GC02P085706
  • GC02P086105
  • GC02P085786
  • GC02P085723
  • GC02P085665
  • GC02P085811
  • GC02P085708

Summaries for VAMP5 Gene

Entrez Gene Summary for VAMP5 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP5 Gene

VAMP5 (Vesicle Associated Membrane Protein 5) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNARE binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for VAMP5 Gene

  • May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP5 Gene

Genomics for VAMP5 Gene

Regulatory Elements for VAMP5 Gene

Enhancers for VAMP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G085563 1.1 Ensembl ENCODE 12.4 -20.2 -20243 0.7 HDAC1 ATF1 CREB3L1 NFRKB ZNF766 IKZF2 CREM CAVIN1 NCOA1 JUNB TMEM150A USP39 VAMP5 MAT2A SH2D6 CAPG ELMOD3 RETSAT GC02M085574 RN7SL126P
GH02G085497 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -84.5 -84525 4.7 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 USP39 MAT2A SNORD94 LOC100996506 RNU7-64P RN7SL251P CAPG C2orf68 TCF7L1 TMEM150A
GH02G085502 1.4 Ensembl ENCODE dbSUPER 6.8 -79.3 -79258 5.7 SIN3A GATA2 FOS DEK ZNF263 SP5 ZNF623 ZNF592 MAFF SMARCA4 USP39 RN7SL251P RNU7-64P MAT2A TMEM150A SH2D6 CAPG ELMOD3 RETSAT VAMP5
GH02G085594 1.1 ENCODE 4.8 +11.5 11483 3.7 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A ZNF2 YY1 ZNF766 FOS USP39 VAMP8 GGCX RNF181 VAMP5 GC02M085595
GH02G085455 1.2 ENCODE dbSUPER 4.4 -126.8 -126836 4.7 HDGF ARID4B SIN3A YBX1 BRCA1 ZNF207 FOS MCM3 NFYC MIER2 CAPG SH2D6 MAT2A RETSAT ELMOD3 USP39 TGOLN2 VAMP5 GC02M085461 ENSG00000199936
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAMP5 on UCSC Golden Path with GeneCards custom track

Promoters for VAMP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119598 92 601 HNRNPUL1 MLX ZFP64 DMAP1 ZNF48 YY1 SLC30A9 PAF1 SP5 MXD4

Genomic Location for VAMP5 Gene

85,584,408 bp from pter
85,593,412 bp from pter
9,005 bases
Plus strand

Genomic View for VAMP5 Gene

Genes around VAMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP5 Gene

Proteins for VAMP5 Gene

  • Protein details for VAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-associated membrane protein 5
    Protein Accession:
    Secondary Accessions:
    • Q9P0T2

    Protein attributes for VAMP5 Gene

    116 amino acids
    Molecular mass:
    12805 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VAMP5 Gene

Post-translational modifications for VAMP5 Gene

  • Ubiquitination at isoforms=26 and Lys33
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP5 Gene

Domains & Families for VAMP5 Gene

Gene Families for VAMP5 Gene

Protein Domains for VAMP5 Gene


Suggested Antigen Peptide Sequences for VAMP5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptobrevin family.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP5: view

Function for VAMP5 Gene

Molecular function for VAMP5 Gene

UniProtKB/Swiss-Prot Function:
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
UniProtKB/Swiss-Prot Induction:
During myogenesis.

Gene Ontology (GO) - Molecular Function for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with VAMP5: view
genes like me logo Genes that share phenotypes with VAMP5: view

Animal Model Products

CRISPR Products

miRNA for VAMP5 Gene

miRTarBase miRNAs that target VAMP5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP5 Gene

Localization for VAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP5 Gene

Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAMP5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 4
cytosol 3
endosome 3
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome ISS,IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS 9725904
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 21151919
genes like me logo Genes that share ontologies with VAMP5: view

Pathways & Interactions for VAMP5 Gene

genes like me logo Genes that share pathways with VAMP5: view

Pathways by source for VAMP5 Gene

1 KEGG pathway for VAMP5 Gene

Gene Ontology (GO) - Biological Process for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0006906 vesicle fusion IBA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development TAS 9725904
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with VAMP5: view

No data available for SIGNOR curated interactions for VAMP5 Gene

Drugs & Compounds for VAMP5 Gene

No Compound Related Data Available

Transcripts for VAMP5 Gene

mRNA/cDNA for VAMP5 Gene

Unigene Clusters for VAMP5 Gene

Vesicle-associated membrane protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -

Relevant External Links for VAMP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VAMP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAMP5 Gene

This gene is overexpressed in Bone (18.0) and Liver (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAMP5 Gene

Protein tissue co-expression partners for VAMP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of VAMP5 Gene:


SOURCE GeneReport for Unigene cluster for VAMP5 Gene:


Evidence on tissue expression from TISSUES for VAMP5 Gene

  • Lung(4.4)
  • Blood(4.1)
  • Muscle(3)
genes like me logo Genes that share expression patterns with VAMP5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP5 Gene

Orthologs for VAMP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VAMP5 34 35
  • 99.14 (n)
(Canis familiaris)
Mammalia VAMP5 34 35
  • 83.77 (n)
(Bos Taurus)
Mammalia VAMP5 34 35
  • 82.9 (n)
(Mus musculus)
Mammalia Vamp5 34 16 35
  • 79.33 (n)
(Rattus norvegicus)
Mammalia Vamp5 34
  • 78 (n)
(Ornithorhynchus anatinus)
Mammalia VAMP5 35
  • 56 (a)
(Danio rerio)
Actinopterygii vamp5 35
  • 33 (a)
Species where no ortholog for VAMP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAMP5 Gene

Gene Tree for VAMP5 (if available)
Gene Tree for VAMP5 (if available)

Paralogs for VAMP5 Gene

(6) SIMAP similar genes for VAMP5 Gene using alignment to 2 proteins: Pseudogenes for VAMP5 Gene

genes like me logo Genes that share paralogs with VAMP5: view

No data available for Paralogs for VAMP5 Gene

Variants for VAMP5 Gene

Sequence variations from dbSNP and Humsavar for VAMP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000071228 -- 85,587,633(+) TAGCT(C/T)TTATT intron-variant
rs1000186252 -- 85,585,309(+) CTCCC(-/T)TTTCC intron-variant
rs1000494913 -- 85,592,527(+) GCCGG(A/G)CGCGG intron-variant
rs1000601908 -- 85,587,278(+) TTTGA(A/G)ACAGA intron-variant
rs1000640763 -- 85,593,553(+) GAGTG(C/T)GGATG intron-variant, upstream-variant-2KB

Variation tolerance for VAMP5 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VAMP5 Gene

Disorders for VAMP5 Gene

Relevant External Links for VAMP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VAMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAMP5 Gene

Publications for VAMP5 Gene

  1. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. (PMID: 9725904) Zeng Q. … Hong W. (Mol. Biol. Cell 1998) 2 3 4 22 64
  2. VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. (PMID: 16110299) Brinkman J.F. … Bergen A.A. (Mol. Vis. 2005) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for VAMP5 Gene

Sources for VAMP5 Gene

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