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Aliases for VAMP5 Gene

Aliases for VAMP5 Gene

  • Vesicle Associated Membrane Protein 5 2 3 5
  • Myobrevin 2 3 4
  • VAMP-5 3 4
  • Vesicle-Associated Membrane Protein 5 3

External Ids for VAMP5 Gene

Previous GeneCards Identifiers for VAMP5 Gene

  • GC02P085706
  • GC02P086105
  • GC02P085786
  • GC02P085723
  • GC02P085665
  • GC02P085811
  • GC02P085708

Summaries for VAMP5 Gene

Entrez Gene Summary for VAMP5 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP5 Gene

VAMP5 (Vesicle Associated Membrane Protein 5) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for VAMP5 Gene

  • May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

Additional gene information for VAMP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP5 Gene

Genomics for VAMP5 Gene

GeneHancer (GH) Regulatory Elements for VAMP5 Gene

Promoters and enhancers for VAMP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I085582 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.4 +0.4 424 3.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 VAMP5 VAMP8 GGCX CAPG SH2D6 MAT2A ELMOD3 RETSAT USP39 RNF181
GH02I085563 Enhancer 1 Ensembl ENCODE 12.4 -20.2 -20243 0.7 HDAC1 ATF1 NFRKB IRF4 ZNF766 E2F8 ATF7 IKZF2 CREM CAVIN1 TMEM150A USP39 VAMP5 MAT2A CAPG SH2D6 ELMOD3 RETSAT GC02M085574 RN7SL126P
GH02I085497 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -84.5 -84525 4.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 POLR2B ZNF766 CBX5 MAT2A USP39 ELMOD3 SNORD94 RN7SL251P RNU7-64P CAPG TCF7L1 TMEM150A SH2D6
GH02I085594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.8 +11.5 11482 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 RNF181 GC02M085595 USP39 VAMP8 GGCX VAMP5
GH02I085502 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.8 -79.3 -79258 5.7 SREBF2 KLF17 SIN3A RAD21 RFX5 SCRT2 FOS DEK SMARCC1 RXRA USP39 RN7SL251P RNU7-64P MAT2A TMEM150A CAPG SH2D6 ELMOD3 RETSAT VAMP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VAMP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VAMP5 gene promoter:

Genomic Locations for VAMP5 Gene

Genomic Locations for VAMP5 Gene
chr2:85,584,408-85,593,412
(GRCh38/hg38)
Size:
9,005 bases
Orientation:
Plus strand
chr2:85,811,531-85,820,535
(GRCh37/hg19)

Genomic View for VAMP5 Gene

Genes around VAMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP5 Gene

Proteins for VAMP5 Gene

  • Protein details for VAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95183-VAMP5_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 5
    Protein Accession:
    O95183
    Secondary Accessions:
    • Q9P0T2

    Protein attributes for VAMP5 Gene

    Size:
    116 amino acids
    Molecular mass:
    12805 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VAMP5 Gene

Post-translational modifications for VAMP5 Gene

  • Ubiquitination at posLast=2626 and isoforms=33

Other Protein References for VAMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP5 Gene

Domains & Families for VAMP5 Gene

Gene Families for VAMP5 Gene

Protein Domains for VAMP5 Gene

Suggested Antigen Peptide Sequences for VAMP5 Gene

Graphical View of Domain Structure for InterPro Entry

O95183

UniProtKB/Swiss-Prot:

VAMP5_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP5: view

Function for VAMP5 Gene

Molecular function for VAMP5 Gene

UniProtKB/Swiss-Prot Function:
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
UniProtKB/Swiss-Prot Induction:
During myogenesis.

Phenotypes From GWAS Catalog for VAMP5 Gene

Gene Ontology (GO) - Molecular Function for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with VAMP5: view
genes like me logo Genes that share phenotypes with VAMP5: view

Animal Model Products

miRNA for VAMP5 Gene

miRTarBase miRNAs that target VAMP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP5 Gene

Localization for VAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP5 Gene

Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAMP5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 4
cytosol 3
endosome 3
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome ISS,IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS 9725904
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 21151919
genes like me logo Genes that share ontologies with VAMP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP5 Gene

Pathways & Interactions for VAMP5 Gene

genes like me logo Genes that share pathways with VAMP5: view

Pathways by source for VAMP5 Gene

1 KEGG pathway for VAMP5 Gene

Gene Ontology (GO) - Biological Process for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0006906 vesicle fusion IBA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development TAS 9725904
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with VAMP5: view

No data available for SIGNOR curated interactions for VAMP5 Gene

Drugs & Compounds for VAMP5 Gene

No Compound Related Data Available

Transcripts for VAMP5 Gene

mRNA/cDNA for VAMP5 Gene

Unigene Clusters for VAMP5 Gene

Vesicle-associated membrane protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for VAMP5 Gene

GeneLoc Exon Structure for
VAMP5
ECgene alternative splicing isoforms for
VAMP5

Expression for VAMP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAMP5 Gene

This gene is overexpressed in Bone (18.0) and Liver (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAMP5 Gene



Protein tissue co-expression partners for VAMP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of VAMP5 Gene:

VAMP5

SOURCE GeneReport for Unigene cluster for VAMP5 Gene:

Hs.534373

Evidence on tissue expression from TISSUES for VAMP5 Gene

  • Lung(4.4)
  • Blood(4.1)
  • Muscle(3)
genes like me logo Genes that share expression patterns with VAMP5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP5 Gene

Orthologs for VAMP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP5 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia VAMP5 33 34
  • 83.77 (n)
cow
(Bos Taurus)
Mammalia VAMP5 33 34
  • 82.9 (n)
mouse
(Mus musculus)
Mammalia Vamp5 33 16 34
  • 79.33 (n)
rat
(Rattus norvegicus)
Mammalia Vamp5 33
  • 78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP5 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vamp5 34
  • 33 (a)
OneToOne
Species where no ortholog for VAMP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAMP5 Gene

ENSEMBL:
Gene Tree for VAMP5 (if available)
TreeFam:
Gene Tree for VAMP5 (if available)

Paralogs for VAMP5 Gene

(6) SIMAP similar genes for VAMP5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VAMP5 Gene

genes like me logo Genes that share paralogs with VAMP5: view

No data available for Paralogs for VAMP5 Gene

Variants for VAMP5 Gene

Sequence variations from dbSNP and Humsavar for VAMP5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000071228 -- 85,587,633(+) C/T intron_variant
rs1000186252 -- 85,585,310(+) TTT/TTTT intron_variant
rs1000494913 -- 85,592,527(+) G/A intron_variant
rs1000601908 -- 85,587,278(+) G/A intron_variant
rs1000640763 -- 85,593,553(+) T/C downstream_transcript_variant

Variation tolerance for VAMP5 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VAMP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VAMP5 Gene

Disorders for VAMP5 Gene

Additional Disease Information for VAMP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VAMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAMP5 Gene

Publications for VAMP5 Gene

  1. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. (PMID: 9725904) Zeng Q … Hong W (Molecular biology of the cell 1998) 2 3 4 22 58
  2. VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. (PMID: 16110299) Brinkman JF … Bergen AA (Molecular vision 2005) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 58

Products for VAMP5 Gene

Sources for VAMP5 Gene

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