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Aliases & Descriptions for VAMP5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Myobrevin 3 | | VAMP-5 3 | | myobrevin 2 |
| | | Descriptions |
|---|
| vesicle-associated membrane protein 5 2 | | vesicle-associated membrane protein 5 (myobrevin) 2 |
|
| | Search outside databases for aliases for VAMP5 genePrevious GC identifers: GC02P085706 GC02P086105 GC02P085786 GC02P085723 |
Summaries for VAMP5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAMP5: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: VAMP5_HUMAN, O95183Function: May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking |
Genomic Location for VAMP5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAMP5 gene 
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2VAMP5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P085665:
(about GC identifiers)
Start:
|
85,665,042 bp from pter |
End:
|
85,674,022 bp from pter |
Size:
|
8,981 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for VAMP5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAMP5_HUMAN, O95183 (See
protein sequence)Recommended Name: Vesicle-associated membrane protein 5 Size: 116 amino acids; 12805 Da
Subcellular location: Cell membrane; Single-pass type IV membrane protein (Probable). Endomembrane system; Single-pass type IV membrane protein (Probable). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity)
Secondary accessions: Q9P0T2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006625.1
ENSEMBL proteins: ENSP00000305647
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VAMP5: Assays for VAMP5: | Protein
Domains/ Families for VAMP5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95183
ProtoNet protein and cluster: O95183 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: VAMP5_HUMAN, O95183Similarity: Belongs to the synaptobrevin familySimilarity: Contains 1 v-SNARE coiled-coil homology domain | Gene Function for VAMP5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006634
Applied Biosystems Silencer® siRNAs for VAMP5
Sigma-Aldrich siRNA for VAMP5  Sigma-Aldrich shRNA for VAMP5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006634                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006634                                  untagged cDNA clone in CMV expression vector: NM_006634 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006634
UniProtKB/Swiss-Prot: VAMP5_HUMAN, O95183Function: May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 traffickingInduction: During myogenesis | Pathways & Interactions for VAMP5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VAMP5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAMP5
|
Transcripts for VAMP5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006634
Sigma-Aldrich siRNA for VAMP5  Sigma-Aldrich shRNA for VAMP5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006634 REFSEQ mRNAs for VAMP5 gene: NM_006634.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006634               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006634                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006634                                  untagged cDNA clone in CMV expression vector: NM_006634  Additional cDNA sequence: AF054825.1 AF077197.1 AF151025.1 AK292660.1 BC017891.1 CR542215.1 3 DOTS entries: DT.314218 DT.100748293 DT.92431991 24/316 AceView cDNA sequences (see all 316
):AA305331 W80846 BX092149 AA634593 BQ675243 BM707971 AA309787 AA371270 AA365845 AI079353 BM761526 CB156929 BM702226 AI418592 AI568721 F27921 BI836255 BM887680 BC017891 N90862 CB108371 CD369345 NM_006634 BQ021316
highest scoring ESTs for VAMP5:AF054825 AA056741 AA147362 AA301711 AA309787 AA341743 AA365845 AA521036 AA595920 AA641625 Unigene Cluster for VAMP5: Vesicle-associated membrane protein 5 (myobrevin) Hs.534373 [show with all ESTs]Unigene Representative Sequence: BG535701
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP5
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAMP5
1 Ensembl transcript including schematic representation: ENST00000306384
|
Expression for VAMP5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAMP5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAMP5
1 / 2 / 3 3 probe-sets matching VAMP5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGGGCCAGC
SOURCE GeneReport for Unigene cluster: Hs.534373
Expression variation in blood from EXPOLDB for VAMP5 |
Orthologs for VAMP5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAMP5 gene from 5 species
About this table Species with no ortholog for VAMP5
ENSEMBL Gene Tree for VAMP5 | Paralogs for VAMP5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAMP5 gene
- VAMP82 VAMP42
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for VAMP5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAMP5 (up to first 250kb)
|
Disorders & Mutations for VAMP5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607029
1 PharmGKB disease relationship for VAMP5 geneAbout this table
Genetic Association Database: VAMP5 Human Genome Epidemiology Navigator: VAMP5 (6 documents)
|
Medical News for VAMP5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAMP5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for VAMP5 gene:- A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. (PubMed id 9725904)1, 2, 3, 4 Zeng Q.... Hong W. (1998)
- VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. (PubMed id 16110299)3, 6 Brinkman J.F....Bergen A.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)3, 4 Zhang Q.H....Chen Z. (2000)
- The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. (PubMed id 12682051)3 Zeng Q....Hong W. (2003)
- Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)7 Yeoh E.J....Downing J.R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for VAMP5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAMP5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAMP5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAMP5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAMP5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAMP5:

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