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Aliases for VAMP5 Gene

Aliases for VAMP5 Gene

  • Vesicle Associated Membrane Protein 5 2 3 5
  • Myobrevin 2 3 4
  • VAMP-5 3 4

External Ids for VAMP5 Gene

Previous GeneCards Identifiers for VAMP5 Gene

  • GC02P085706
  • GC02P086105
  • GC02P085786
  • GC02P085723
  • GC02P085665
  • GC02P085811
  • GC02P085708

Summaries for VAMP5 Gene

Entrez Gene Summary for VAMP5 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP5 Gene

VAMP5 (Vesicle Associated Membrane Protein 5) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNARE binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for VAMP5 Gene

  • May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP5 Gene

Genomics for VAMP5 Gene

Regulatory Elements for VAMP5 Gene

Promoters for VAMP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAMP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAMP5 Gene

Chromosome:
2
Start:
85,584,408 bp from pter
End:
85,593,412 bp from pter
Size:
9,005 bases
Orientation:
Plus strand

Genomic View for VAMP5 Gene

Genes around VAMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP5 Gene

Proteins for VAMP5 Gene

  • Protein details for VAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95183-VAMP5_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 5
    Protein Accession:
    O95183
    Secondary Accessions:
    • Q9P0T2

    Protein attributes for VAMP5 Gene

    Size:
    116 amino acids
    Molecular mass:
    12805 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VAMP5 Gene

Proteomics data for VAMP5 Gene at MOPED

Post-translational modifications for VAMP5 Gene

  • Ubiquitination at Lys 26 and Lys 33
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VAMP5 Gene

Domains & Families for VAMP5 Gene

Gene Families for VAMP5 Gene

Protein Domains for VAMP5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VAMP5 Gene

Graphical View of Domain Structure for InterPro Entry

O95183

UniProtKB/Swiss-Prot:

VAMP5_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP5: view

Function for VAMP5 Gene

Molecular function for VAMP5 Gene

UniProtKB/Swiss-Prot Function:
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
UniProtKB/Swiss-Prot Induction:
During myogenesis.

Gene Ontology (GO) - Molecular Function for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with VAMP5: view
genes like me logo Genes that share phenotypes with VAMP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VAMP5

miRNA for VAMP5 Gene

miRTarBase miRNAs that target VAMP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP5 Gene

Localization for VAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP5 Gene

Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP5 Gene COMPARTMENTS Subcellular localization image for VAMP5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytosol 3
endosome 3
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 21151919
GO:0014704 intercalated disc IEA,ISS --
GO:0030659 cytoplasmic vesicle membrane IEA,ISS --
GO:0031201 SNARE complex IBA --
GO:0031301 integral component of organelle membrane IEA,ISS --
genes like me logo Genes that share ontologies with VAMP5: view

Pathways & Interactions for VAMP5 Gene

genes like me logo Genes that share pathways with VAMP5: view

Pathways by source for VAMP5 Gene

1 KEGG pathway for VAMP5 Gene

Gene Ontology (GO) - Biological Process for VAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with VAMP5: view

No data available for SIGNOR curated interactions for VAMP5 Gene

Drugs & Compounds for VAMP5 Gene

No Compound Related Data Available

Transcripts for VAMP5 Gene

mRNA/cDNA for VAMP5 Gene

Unigene Clusters for VAMP5 Gene

Vesicle-associated membrane protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for VAMP5 Gene

GeneLoc Exon Structure for
VAMP5
ECgene alternative splicing isoforms for
VAMP5

Expression for VAMP5 Gene

mRNA expression in normal human tissues for VAMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAMP5 Gene

This gene is overexpressed in Bone (18.0) and Liver (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP5 Gene



SOURCE GeneReport for Unigene cluster for VAMP5 Gene Hs.534373

genes like me logo Genes that share expression patterns with VAMP5: view

Protein tissue co-expression partners for VAMP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VAMP5 Gene

Orthologs for VAMP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAMP5 35
  • 82.9 (n)
  • 75.65 (a)
VAMP5 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAMP5 35
  • 83.77 (n)
  • 76.52 (a)
VAMP5 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp5 35
  • 79.33 (n)
  • 74 (a)
Vamp5 16
Vamp5 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP5 35
  • 99.14 (n)
  • 98.28 (a)
VAMP5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp5 35
  • 78 (n)
  • 72 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP5 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vamp5 36
  • 33 (a)
OneToOne
Species with no ortholog for VAMP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VAMP5 Gene

ENSEMBL:
Gene Tree for VAMP5 (if available)
TreeFam:
Gene Tree for VAMP5 (if available)

Paralogs for VAMP5 Gene

(6) SIMAP similar genes for VAMP5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VAMP5 Gene

genes like me logo Genes that share paralogs with VAMP5: view

No data available for Paralogs for VAMP5 Gene

Variants for VAMP5 Gene

Sequence variations from dbSNP and Humsavar for VAMP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11311 -- 85,584,469(+) GCGGG(C/T)GAGGC utr-variant-5-prime
rs14298 -- 85,593,199(+) CTGGC(C/T)GATTC utr-variant-3-prime
rs14976 -- 85,591,763(-) ACCTC(A/G)TTCGC reference, synonymous-codon
rs719023 -- 85,591,365(-) ACCCA(A/G)TCAAT intron-variant
rs1049359 -- 85,593,250(-) CTCAC(C/T)GGGGT utr-variant-3-prime

Variation tolerance for VAMP5 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP5 Gene

HapMap Linkage Disequilibrium report
VAMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VAMP5 Gene

Disorders for VAMP5 Gene

Relevant External Links for VAMP5

Genetic Association Database (GAD)
VAMP5
Human Genome Epidemiology (HuGE) Navigator
VAMP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP5

No disorders were found for VAMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAMP5 Gene

Publications for VAMP5 Gene

  1. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. (PMID: 9725904) Zeng Q. … Hong W. (Mol. Biol. Cell 1998) 2 3 4 23 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for VAMP5 Gene

Sources for VAMP5 Gene

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