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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VAMP4 Gene

protein-coding GIFtS: 64
GCID: GC01M171669

vesicle-associated membrane protein 4

Explore 2 diseases affiliated with
VAMP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vesicle-Associated Membrane Protein 4¹ ²
VAMP-4² ³
VAMP24² ⁵

External Ids:	HGNC: 12645¹	Entrez Gene: 8674²	Ensembl: ENSG00000117533⁷	OMIM: 606909⁵	UniProtKB: O75379³

ORGUL members:
	NONCODE:n409344

Export aliases for VAMP4 gene to outside databases

Previous GC identifers: GC01M169237 GC01M167298 GC01M168250 GC01M168908 GC01M168400 GC01M169935 GC01M142893

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP4:

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a

protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein

encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein

may play a role in trans-Golgi network-to-endosome transport. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379

Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered

exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for

remodeling the secretory response of granule

Gene Wiki entry for VAMP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VAMP4 gene promoter:
Pax-5 AP-1 ATF-2 RelA NF-kappaB FOXJ2 (long isoform) FOXJ2 c-Jun NF-kappaB1 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VAMP4 promoter sequence

Search SABiosciences Chromatin IP Primers for VAMP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24-q25 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24-q25

VAMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M171669: view genomic region (about GC identifiers)

Start:	171,669,296 bp from pter	End:	171,711,387 bp from pter
Size:	42,092 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379 (See protein sequence)

Recommended Name: Vesicle-associated membrane protein 4

Size: 141 amino acids; 16397 Da

Subunit: Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity)

Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable).

Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the

mature secretory organelles

Secondary accessions: A2IDD8 Q96IY9 Q96J20 Q9UEL7

Alternative splicing: 2 isoforms: O75379-1 O75379-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VAMP4: NX_O75379

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75379

VAMP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001172056.1 NP_003753.2

ENSEMBL proteins:

ENSP00000236192 ENSP00000435933 ENSP00000356714 ENSP00000415627

Human Recombinant Protein Products:

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	Novus Biologicals VAMP4 Proteins Novus Biologicals VAMP4 Lysate
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	ProSpec Recombinant Protein for VAMP4
	Uscn Proteins for VAMP4

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	9553086
GO:0005764	lysosome	TAS	9553086
GO:0005768	endosome	TAS	9553086
GO:0005802	trans-Golgi network	IEA	--
GO:0016021	integral to membrane	IEA	--

VAMP4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for VAMP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VAMP4 for domains About GeneDecksing

2 InterPro domains/families:

IPR016444 Synaptobrevin_met/fun

IPR001388 Synaptobrevin

Graphical View of Domain Structure for InterPro Entry O75379

ProtoNet protein and cluster: O75379

1 Blocks protein family: IPB001388 Synaptobrevin

UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379

Similarity: Belongs to the synaptobrevin family

Similarity: Contains 1 v-SNARE coiled-coil homology domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379

Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered

exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for

remodeling the secretory response of granule

miRNA Products:		OriGene 3'-UTR Clone: VAMP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP4
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP4 (see all 54):
		hsa-miR-2052 hsa-miR-579 hsa-miR-3194-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-miR-3616-5p hsa-miR-578

		SwitchGear 3'UTR luciferase reporter plasmid: VAMP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAMP4 (see all 7) OriGene shRNA RFP: VAMP4 OriGene siRNA: VAMP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAMP4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VAMP4

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAMP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VAMP4
		Search LifeMap BioReagents cell lines for VAMP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP4

Animal Models:
1 MGI phenotypic allele

for Vamp4 (no phenotypes)

VAMP4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1.00

SNARE interactions in vesicular transport

0.40

Clathrin-dependent protein traffic

Transport_Clathrin-coated vesicle cycle

0.66

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for VAMP4

Transport Clathrin-coated vesicle cycle

1 PharmGKB Pathway for VAMP4

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1 Kegg Pathway (Kegg details for VAMP4):

SNARE interactions in vesicular transport

VAMP4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VAMP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/27 Interacting proteins for VAMP4 (O75379^{2, 3} ENSP00000236192⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STX4	Q12846²^,³, ENSP00000317714⁴	MINT-66593 I2D: score=5 STRING: ENSP00000317714
STX6	O43752²^,³, ENSP00000258301⁴	MINT-7255483 MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=3 STRING: ENSP00000258301
VTI1A	Q96AJ9²^,³, ENSP00000376792⁴	MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=1 STRING: ENSP00000376792
STX12	Q86Y82²	MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351
STX16	O14662³, ENSP00000360183⁴	I2D: score=3 STRING: ENSP00000360183

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016192	vesicle-mediated transport	--	--
GO:0042996	regulation of Golgi to plasma membrane protein transport	IEA	--
GO:0043001	Golgi to plasma membrane protein transport	IEA	--

VAMP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VAMP4

1 HMDB Compound for VAMP4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about VAMP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VAMP4 gene (3 alternative transcripts):

NM_001185127.1 NM_003762.4 NM_201994.1

Unigene Cluster for VAMP4:

Vesicle-associated membrane protein 4

Hs.6651 [show with all ESTs]

Unigene Representative Sequence: NM_003762

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000236192(uc001ghv.2 uc001ghw.2 uc001ghx.2 uc001ghy.2)

ENST00000474047 ENST00000367740 ENST00000482519 ENST00000415773

miRNA Products:		OriGene 3'-UTR Clone: VAMP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP4
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP4 (see all 54):
		hsa-miR-2052 hsa-miR-579 hsa-miR-3194-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-miR-3616-5p hsa-miR-578

		SwitchGear 3'UTR luciferase reporter plasmid: VAMP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): VAMP4 (NM_003762)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAMP4
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAMP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP4

Additional cDNA sequence:

AF044310.1 AF052100.1 AK056124.1 AK123624.1 AK290441.1 AL035296.1 BC005974.1 BC007019.1

CR457011.1 NR_033704.1

12 DOTS entries:

DT.92420174 DT.315028 DT.97799210 DT.92420173 DT.95268191 DT.100655461 DT.100716530 DT.121348983

DT.121348988 DT.121348991 DT.92054278 DT.95081374

24/137 AceView cDNA sequences (see all 137):

AI382885 T16554 Z44493 AL035296 T16866 AI375646 AV649282 BU178915

BG283980 N75026 F10934 F05174 AL602755 AL701821 AI040504 AW269429

AK123624 CA447702 AA954039 AA455922 AL597489 AF052100 BQ423480 CB123535

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP4 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b
SP1:													-		-		-										-								-		-		-
SP2:													-		-		-										-
SP3:													-		-		-										-
SP4:													-
SP5:																									-		-

ECgene alternative splicing isoforms for VAMP4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VAMP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCCTGTTC

About this image

VAMP4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VAMP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VAMP4

SOURCE GeneReport for Unigene cluster: Hs.6651

SABiosciences Custom PCR Arrays for VAMP4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for VAMP4 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	VAMP4¹	vesicle-associated membrane protein 4	78.72(n) 90.78(a)		770513 XM_001233851.2 XP_001233852.2
lizard (Anolis carolinensis)	Reptilia	VAMP4⁶	--	93(a)	1 ↔ 1	GL343300.1(1199822-1203605)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12760²	Xenopus laevis transcribed sequence with moderate similarity more	76.8(n)		BI446492.1
zebrafish (Danio rerio)	Actinopterygii	zgc73166²	hypothetical protein MGC73166	78.35(n)		393708 BC059519.1
honey bee (Apis mellifera)	Insecta	--	--	22(a)	1 ↔ 1	Group4.5(619489-620700)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATVAMP722⁶ VAMP728⁶ (see all 8)	vesicle-associated membrane protein 728 (see all 8)	18(a) 18(a) (see all 8)	possible ortholog possible ortholog (see all 8)	2(14043459-14045544) 3(9097514-9098945)
rice (Oryza sativa)	Liliopsida	-- -- (see all 6)	vesicle-associated membrane protein, putative, exp... vesicle-associated membrane protein, putative, exp... (see all 6)	19(a) 18(a) (see all 6)	possible ortholog possible ortholog (see all 6)	3(3550771-3553411) 3(33499951-33503242)

ENSEMBL Gene Tree for VAMP4 (if available)
TreeFam Gene Tree for VAMP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VAMP4 gene

VAMP2² VAMP1² VAMP5² VAMP8² VAMP3² ENSG00000263620²

7 SIMAP similar genes for VAMP4 using alignment to 2 protein entries: VAMP4_HUMAN (see all proteins):

VAMP5 VAMP3 VAMP1 VAMP8 VAMP2 SYBL1

VAMP7

VAMP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12127026^1,2	A,	--	171668813(+)	`CTGAGA/GCTGCA`	3	--	ds500¹		4		NA WA EA	362
rs150228190^1,2	C,	--	171668863(+)	`AGAAC-/AAGAAGAT`	3	--	ds500¹		0	--	--	--	--
rs10913511^1,2	C,F,A,H,	--	171668951(+)	`TGGTTG/ACCTAA`	3	--	ds500¹		24		NS EA NA WA	2930
rs74845389^1,2	F,	--	171669182(+)	`CACTTT/CATTGG`	3	--	ds500¹		1		WA	118
rs145501920^1,2		--	171669228(+)	`AGATGC/TTATTG`	3	--	ds500¹		0	--	--	--	--
rs183459495^1,2		--	171669330(+)	`TTTCAC/TTGTTC`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs187742315^1,2		--	171669339(+)	`TCACTA/CTGGAG`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs192446691^1,2		--	171669423(+)	`ATTGAA/GAAGCT`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs114238145^1,2	F,	--	171669632(+)	`ATGTAA/TTCTAC`	3	--	ut3¹ nc-transcript-variant		1		WA	118
rs147301156^1,2		--	171669742(+)	`TACAGG/TAGAAG`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for VAMP4 (171669296 - 171711387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for VAMP4
2 CNVs: 70414 70415

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VAMP4

DNA2.0 Custom Variant and Variant Library Synthesis for VAMP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VAMP4 for disorders           About GeneDecksing

OMIM gene information: 606909    OMIM disorders: --

2 diseases for VAMP4:    About MalaCards

human granulocytic anaplasmosis malaria

1 disease from the University of Copenhagen DISEASES database for VAMP4:

Human granulocytic anaplasmosis

Genetic Association Database (GAD): VAMP4
Human Genome Epidemiology (HuGE) Navigator: VAMP4 (1 document)

Export disorders for VAMP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for VAMP4 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with VAMP4)

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Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PubMed id 9553086)^{1, 2, 3} Advani R.J.... Scheller R.H. (1998)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. (PubMed id 15896658)^{1, 4} Sabra M.M....Shuldiner A.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PubMed id 11839770)^{1, 9} Mallard F....Johannes L. (2002)
VAMP4 directs synaptic vesicles to a pool that selecti vely maintains asynchronous neurotransmission. (PubMed id 22406549)¹ Raingo J....Kavalali E.T. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
VAMP4- and VAMP7-expressing vesicles are both require d for cytotoxic granule exocytosis in NK cells. (PubMed id 21805468)¹ Krzewski K....Strominger J.L. (2011)
Ang2/fat-free is a conserved subunit of the Golgi-ass ociated retrograde protein complex. (PubMed id 20685960)¹ PAcrez-Victoria F.J....Bonifacino J.S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8674	HGNC: 12645	AceView: VAMP4	Ensembl:ENSG00000117533	euGenes: HUgn8674
ECgene: VAMP4	Kegg: 8674	H-InvDB: VAMP4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for VAMP4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VAMP4 gene
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Patent Information for VAMP4 gene:
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vesicle-associated membrane protein 4

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