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Aliases & Descriptions for VAMP4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| vesicle-associated membrane protein 4 2 |
|
| | Search outside databases for aliases for VAMP4 genePrevious GC identifers: GC01M169237 GC01M167298 GC01M168250 GC01M168908 GC01M168400 |
Summaries for VAMP4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAMP4: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq] UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granuleGene Wiki entry for VAMP4 |
Genomic Location for VAMP4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAMP4 gene 
Entrez Gene cytogenetic band: 1q24-q25 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24-q25VAMP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M169935:
(about GC identifiers)
Start:
|
169,935,923 bp from pter |
End:
|
169,977,837 bp from pter |
Size:
|
41,915 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for VAMP4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379 (See
protein sequence)Recommended Name: Vesicle-associated membrane protein 4 Size: 141 amino acids; 16397 Da
Subunit: Identified in a complex containing STX6, STX13, VAMP4 and VTI1A (By similarity)
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles
Secondary accessions: Q96IY9 Q96J20 Q9UEL7Alternative splicing: 2 isoforms: O75379-1 O75379-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003753.2
ENSEMBL proteins: ENSP00000386083 ENSP00000236192 ENSP00000356714
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for VAMP4: Assays for VAMP4: | Protein
Domains/ Families for VAMP4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75379
ProtoNet protein and cluster: O75379 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379Similarity: Belongs to the synaptobrevin familySimilarity: Contains 1 v-SNARE coiled-coil homology domain | Gene Function for VAMP4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003762
Applied Biosystems Silencer® siRNAs for VAMP4
Sigma-Aldrich siRNA for VAMP4  Sigma-Aldrich shRNA for VAMP4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003762                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003762                                  untagged cDNA clone in CMV expression vector: NM_003762 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003762
UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule1 MGI phenotypic allele for Vamp4 (no phenotypes)
| Pathways & Interactions for VAMP4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VAMP4 
5/18 Interacting proteins for VAMP4 (ENSP000003567143 O753792) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016192 | vesicle-mediated transport |
IEA | -- | About this table
|
Drugs & Compounds for VAMP4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAMP4
|
Transcripts for VAMP4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003762
Sigma-Aldrich siRNA for VAMP4  Sigma-Aldrich shRNA for VAMP4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003762 REFSEQ mRNAs for VAMP4 gene: NM_003762.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003762               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003762                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003762                                  untagged cDNA clone in CMV expression vector: NM_003762  Additional cDNA sequence: AF044310.1 AF052100.1 AK056124.1 AK123624.1 AK290441.1 AL035296.1 BC005974.1 BC007019.1 CR457011.1 12 DOTS entries: DT.92420174 DT.315028 DT.97799210 DT.92420173 DT.95268191 DT.100655461 DT.121348983 DT.95081374 DT.100716530 DT.121348988 DT.121348991 DT.92054278 24/137 AceView cDNA sequences (see all 137
):AW295713 AI801689 NM_003762 AI758204 BM927117 T16554 AA771953 AK056124 AW473740 AA299279 AL597489 BU156636 BG428093 AV649282 T16866 AA991347 AI472802 CB123535 BM763166 Z44493 AL035296 BU178915 AA954039 F05174
highest scoring ESTs for VAMP4:AL035296 AA400295 AF052100 AA374514 AA490730 AA774871 AF044310 AL597489 AL602755 AL701821 Unigene Cluster for VAMP4: Vesicle-associated membrane protein 4 Hs.6651 [show with all ESTs]Unigene Representative Sequence: AK123624
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP4 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAMP4
3 Ensembl transcripts including schematic representations: ENST00000401589
ENST00000236192
ENST00000367740
|
Expression for VAMP4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAMP4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAMP4
1 / 2 / 3 10 probe-sets matching VAMP4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCCCTGTTC
SOURCE GeneReport for Unigene cluster: Hs.6651
Expression variation in blood from EXPOLDB for VAMP4 |
Orthologs for VAMP4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAMP4 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VAMP4
ENSEMBL Gene Tree for VAMP4 | Paralogs for VAMP4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAMP4 gene
- VAMP82 VAMP52
|
SNPs/Variants for VAMP4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAMP4 (up to first 250kb)
|
Disorders & Mutations for VAMP4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606909
Genetic Association Database: VAMP4 Human Genome Epidemiology Navigator: VAMP4 (1 document)
|
Medical News for VAMP4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAMP4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for VAMP4 gene (see all 22
):- Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PubMed id 9553086)2, 3, 4 Advani R.J.... Scheller R.H. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. (PubMed id 15896658)3, 6 Sabra M.M....Shuldiner A.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PubMed id 11839770)1, 3 Mallard F....Johannes L. (2002)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)4 Han G.... Gu J. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for VAMP4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAMP4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAMP4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAMP4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAMP4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAMP4:

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Incremental update: 13 Oct 2009
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