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Aliases for VAMP4 Gene

Aliases for VAMP4 Gene

  • Vesicle Associated Membrane Protein 4 2 3 5
  • VAMP-4 3 4
  • VAMP24 3

External Ids for VAMP4 Gene

Previous GeneCards Identifiers for VAMP4 Gene

  • GC01M169237
  • GC01M167298
  • GC01M168250
  • GC01M168908
  • GC01M168400
  • GC01M169935
  • GC01M171669
  • GC01M142893

Summaries for VAMP4 Gene

Entrez Gene Summary for VAMP4 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP4 Gene

VAMP4 (Vesicle Associated Membrane Protein 4) is a Protein Coding gene. Diseases associated with VAMP4 include Mednik Syndrome. Among its related pathways are p53 Pathway (RnD) and Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP4 Gene

  • Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Gene Wiki entry for VAMP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP4 Gene

Genomics for VAMP4 Gene

Regulatory Elements for VAMP4 Gene

Enhancers for VAMP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VAMP4 on UCSC Golden Path with GeneCards custom track

Promoters for VAMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAMP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAMP4 Gene

Chromosome:
1
Start:
171,700,156 bp from pter
End:
171,742,247 bp from pter
Size:
42,092 bases
Orientation:
Minus strand

Genomic View for VAMP4 Gene

Genes around VAMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP4 Gene

Proteins for VAMP4 Gene

  • Protein details for VAMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75379-VAMP4_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 4
    Protein Accession:
    O75379
    Secondary Accessions:
    • A2IDD8
    • Q96IY9
    • Q96J20
    • Q9UEL7

    Protein attributes for VAMP4 Gene

    Size:
    141 amino acids
    Molecular mass:
    16397 Da
    Quaternary structure:
    • Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Alternative splice isoforms for VAMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAMP4 Gene

Proteomics data for VAMP4 Gene at MOPED

Post-translational modifications for VAMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP4 Gene

Antibody Products

  • Abcam antibodies for VAMP4

No data available for DME Specific Peptides for VAMP4 Gene

Domains & Families for VAMP4 Gene

Gene Families for VAMP4 Gene

Protein Domains for VAMP4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75379

UniProtKB/Swiss-Prot:

VAMP4_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP4: view

Function for VAMP4 Gene

Molecular function for VAMP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Gene Ontology (GO) - Molecular Function for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with VAMP4: view

Phenotypes for VAMP4 Gene

genes like me logo Genes that share phenotypes with VAMP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VAMP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP4 Gene

Localization for VAMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP4 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP4 Gene COMPARTMENTS Subcellular localization image for VAMP4 gene
Compartment Confidence
endosome 5
golgi apparatus 5
lysosome 4
vacuole 4
cytosol 3
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 9553086
GO:0009986 cell surface IDA 21151919
GO:0032588 trans-Golgi network membrane TAS --
genes like me logo Genes that share ontologies with VAMP4: view

Pathways & Interactions for VAMP4 Gene

genes like me logo Genes that share pathways with VAMP4: view

Pathways by source for VAMP4 Gene

1 GeneGo (Thomson Reuters) pathway for VAMP4 Gene
1 R&D Systems pathway for VAMP4 Gene

SIGNOR curated interactions for VAMP4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035493 SNARE complex assembly IDA 21151919
GO:0090161 Golgi ribbon formation IMP 23677696
genes like me logo Genes that share ontologies with VAMP4: view

Drugs & Compounds for VAMP4 Gene

(1) Drugs for VAMP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with VAMP4: view

Transcripts for VAMP4 Gene

Unigene Clusters for VAMP4 Gene

Vesicle-associated membrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for VAMP4 Gene

GeneLoc Exon Structure for
VAMP4
ECgene alternative splicing isoforms for
VAMP4

Expression for VAMP4 Gene

mRNA expression in normal human tissues for VAMP4 Gene

Protein differential expression in normal tissues from HIPED for VAMP4 Gene

This gene is overexpressed in Bone (26.9), Pancreas (7.2), Liver (6.5), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP4 Gene



SOURCE GeneReport for Unigene cluster for VAMP4 Gene Hs.6651

genes like me logo Genes that share expression patterns with VAMP4: view

Protein tissue co-expression partners for VAMP4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VAMP4 Gene

Orthologs for VAMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAMP4 35
  • 96.93 (n)
  • 98.58 (a)
VAMP4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp4 35
  • 94.72 (n)
  • 100 (a)
Vamp4 16
Vamp4 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP4 35
  • 100 (n)
  • 100 (a)
VAMP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp4 35
  • 94.17 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia VAMP4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAMP4 35
  • 78.72 (n)
  • 90.78 (a)
VAMP4 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP4 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp4 35
  • 77.07 (n)
  • 85.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12760 35
zebrafish
(Danio rerio)
Actinopterygii vamp4 35
  • 71.19 (n)
  • 78.57 (a)
zgc73166 35
vamp4 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snb-2 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 30 (a)
ManyToMany
SNC2 36
  • 30 (a)
ManyToMany
SNC2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5545 35
Species with no ortholog for VAMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP4 Gene

ENSEMBL:
Gene Tree for VAMP4 (if available)
TreeFam:
Gene Tree for VAMP4 (if available)

Paralogs for VAMP4 Gene

Paralogs for VAMP4 Gene

(7) SIMAP similar genes for VAMP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VAMP4: view

Variants for VAMP4 Gene

Sequence variations from dbSNP and Humsavar for VAMP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10903 -- 171,704,096(+) TTTCA(A/G)CATAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs15655 -- 171,704,132(+) TGACC(A/C)CCAGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs236894 -- 171,700,683(+) ACTGT(A/G)GAGTC nc-transcript-variant, utr-variant-3-prime
rs236895 -- 171,703,419(+) TGTGT(G/T)TGTGT intron-variant, utr-variant-3-prime
rs236896 -- 171,703,473(+) TACAC(A/C)TAGGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VAMP4 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
esv2719529 CNV Deletion 23290073
nsv3509 CNV Insertion 18451855

Variation tolerance for VAMP4 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VAMP4 Gene

Disorders for VAMP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VAMP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mednik syndrome
  • erythrokeratodermia variabilis 3
- elite association - COSMIC cancer census association via MalaCards
Search VAMP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAMP4

Genetic Association Database (GAD)
VAMP4
Human Genome Epidemiology (HuGE) Navigator
VAMP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP4
genes like me logo Genes that share disorders with VAMP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP4 Gene

Publications for VAMP4 Gene

  1. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PMID: 9553086) Advani R.J. … Scheller R.H. (J. Biol. Chem. 1998) 2 3 4 67
  2. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PMID: 11839770) Mallard F. … Johannes L. (J. Cell Biol. 2002) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). (PMID: 26359495) Kuster A. … Proux-Gillardeaux V. (J. Biol. Chem. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for VAMP4 Gene

Sources for VAMP4 Gene

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