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VAMP4 Gene

protein-coding   GIFtS: 61
GCID: GC01M171669

Vesicle-Associated Membrane Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vesicle-Associated Membrane Protein 41 2
VAMP-42 3
VAMP242 5

External Ids:    HGNC: 126451   Entrez Gene: 86742   Ensembl: ENSG000001175337   OMIM: 6069095   UniProtKB: O753793   

Export aliases for VAMP4 gene to outside databases

Previous GC identifers: GC01M169237 GC01M167298 GC01M168250 GC01M168908 GC01M168400 GC01M169935 GC01M142893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAMP4 Gene:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a
protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The
protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family.
This protein may play a role in trans-Golgi network-to-endosome transport. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAMP4 Gene:
VAMP4 (vesicle-associated membrane protein 4) is a protein-coding gene. Diseases associated with VAMP4 include human granulocytic anaplasmosis, and vesiculitis. An important paralog of this gene is VAMP2.

UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379
Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of
calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting
pathway that is critical for remodeling the secretory response of granule

Gene Wiki entry for VAMP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAMP4 gene promoter:
         Pax-5   AP-1   ATF-2   RelA   NF-kappaB   FOXJ2 (long isoform)   FOXJ2   c-Jun   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP4 promoter sequence
   Search Chromatin IP Primers for VAMP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAMP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24-q25   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24-q25

VAMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M171669:  view genomic region     (about GC identifiers)

Start:
171,669,296 bp from pter      End:
171,711,387 bp from pter
Size:
42,092 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for VAMP4

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 4  
Size: 141 amino acids; 16397 Da
Subunit: Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity)
Secondary accessions: A2IDD8 Q96IY9 Q96J20 Q9UEL7
Alternative splicing: 2 isoforms:  O75379-1   O75379-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VAMP4: NX_O75379

Explore proteomics data for VAMP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VAMP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001172056.1  NP_003753.2  

    ENSEMBL proteins: 
     ENSP00000236192   ENSP00000435933   ENSP00000356714   ENSP00000415627  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VAMP: Vesicle-associated membrane proteins

    2 InterPro protein domains:
     IPR016444 Synaptobrevin/VAMP_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry O75379

    ProtoNet protein and cluster: O75379

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP4_HUMAN, O75379
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP4_HUMAN, O75379
    Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of
    calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting
    pathway that is critical for remodeling the secretory response of granule

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
         
    VAMP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Vamp4 (no phenotypes)

    VAMP4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAMP4
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    miRNA
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    Block miRNA regulation of human, mouse, rat VAMP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAMP4 (see all 54):
    hsa-miR-2052 hsa-miR-579 hsa-miR-3194-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-miR-3616-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidVAMP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VAMP4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): VAMP4 (NM_003762)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VAMP4_HUMAN, O75379: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein
    (Probable). Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG).
    Not found on the mature secretory organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome4
    golgi apparatus4
    lysosome4
    vacuole4
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS9553086
    GO:0005764lysosome TAS9553086
    GO:0005768endosome TAS9553086
    GO:0005794Golgi apparatus ----
    GO:0005802trans-Golgi network IEA--

    VAMP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAMP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for VAMP4
        Transport Clathrin-coated vesicle cycle

    1 PharmGKB Pathway for VAMP4
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for VAMP4):
        SNARE interactions in vesicular transport


    VAMP4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VAMP4
    Interactions:

        GeneGlobe Interaction Network for VAMP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAMP4 (O753792, 3 ENSP000002361924) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX4Q128462, 3, ENSP000003177144MINT-66593 I2D: score=5 STRING: ENSP00000317714
    STX6O437522, 3, ENSP000002583014MINT-7255483 MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=3 STRING: ENSP00000258301
    VTI1AQ96AJ92, 3, ENSP000003767924MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=1 STRING: ENSP00000376792
    STX12Q86Y822MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351
    STX16O146623, ENSP000003601834I2D: score=3 STRING: ENSP00000360183
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IBA--
    GO:0006897endocytosis IBA--
    GO:0006906vesicle fusion IBA--
    GO:0016192vesicle-mediated transport ----
    GO:0042996regulation of Golgi to plasma membrane protein transport IEA--

    VAMP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAMP4

    1 HMDB Compound for VAMP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VAMP4 gene (3 alternative transcripts): 
    NM_001185127.1  NM_003762.4  NM_201994.1  

    Unigene Cluster for VAMP4:

    Vesicle-associated membrane protein 4
    Hs.6651  [show with all ESTs]
    Unigene Representative Sequence: NM_003762
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236192(uc001ghv.2 uc001ghw.2 uc001ghx.2 uc001ghy.2)
    ENST00000474047 ENST00000367740 ENST00000482519 ENST00000415773
    miRNA
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    Block miRNA regulation of human, mouse, rat VAMP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAMP4 (see all 54):
    hsa-miR-2052 hsa-miR-579 hsa-miR-3194-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-miR-3616-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidVAMP4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat VAMP4
      QuantiFast Probe-based Assays in human, mouse, rat VAMP4

    Additional mRNA sequence: 

    AF044310.1 AF052100.1 AK056124.1 AK123624.1 AK290441.1 AL035296.1 BC005974.1 BC007019.1 
    CR457011.1 NR_033704.1 

    12 DOTS entries:

    DT.92420174  DT.315028  DT.97799210  DT.92420173  DT.95268191  DT.100655461  DT.100716530  DT.121348983 
    DT.121348988  DT.121348991  DT.92054278  DT.95081374 

    Selected AceView cDNA sequences (see all 137):

    AF052100 AI040504 BU178915 AW295713 BQ423480 NM_201994 AI472802 F13519 
    F10934 BX480197 AA954039 AV649282 AI375646 CA447702 AK123624 AI382885 
    AL035296 BM763166 AA771953 T16554 AL701821 AL597489 T16866 BU156636 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAMP4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b
    SP1:                                      -     -     -                             -                       -     -     -               
    SP2:                                      -     -     -                             -                                                   
    SP3:                                      -     -     -                             -                                                   
    SP4:                                      -                                                                                             
    SP5:                                                                          -     -                                                   


    ECgene alternative splicing isoforms for VAMP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAMP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCTGTTC
    VAMP4 Expression
    About this image

    VAMP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAMP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6651
        Custom PCR Arrays for VAMP4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp41 , 5 vesicle-associated membrane protein 41, 5 94.72(n)1
    100(a)1
      1 (70.29 cM)5
    533301  NM_016796.31  NP_058076.21 
     1625705155 
    chicken
    (Gallus gallus)
    Aves VAMP41 vesicle-associated membrane protein 4 78.72(n)
    90.78(a)
      770513  XM_001233851.3  XP_001233852.2 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP46
    vesicle-associated membrane protein 4
    93(a)
    1 ↔ 1
    GL343300.1(1199822-1203605)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127602 Xenopus laevis transcribed sequence with moderate similarity more 76.8(n)    BI446492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731662 hypothetical protein MGC73166 78.35(n)   393708  BC059519.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snb-26
    Protein SNB-2 (snb-2) mRNA, complete cds
    28(a)
    many ↔ many
    V(12344186-12345919) WBGene00004898
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNC2(YOR327C)4 Vesicle membrane receptor protein (v-SNARE) involved more   --   15(931081-930734) 854505  NP_014972.1 


    ENSEMBL Gene Tree for VAMP4 (if available)
    TreeFam Gene Tree for VAMP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAMP4 gene
    VAMP22  VAMP12  VAMP82  VAMP32  ENSG000002636202  
    7 SIMAP similar genes for VAMP4 using alignment to 2 protein entries:     VAMP4_HUMAN (see all proteins):
    VAMP5    VAMP3    VAMP1    VAMP8    VAMP2    SYBL1
    VAMP7

    VAMP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAMP4 (see all 834)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121270261,2
    C,A--171668813(+) CTGAGA/GCTGCA 3 -- ds50014Minor allele frequency- G:0.16NA WA EA 362
    rs1502281901,2
    C--171668863(+) AGAAC-/AAGAAGAT 3 -- cds1 ds50010--------
    rs109135111,2
    C,F,A,H--171668951(+) TGGTTG/ACCTAA 3 -- ds500124Minor allele frequency- A:0.15NS EA NA WA 2930
    rs748453891,2
    C,F--171669182(+) CACTTT/CATTGG 3 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1455019201,2
    --171669228(+) AGATGC/TTATTG 3 -- ds50010--------
    rs1834594951,2
    --171669330(+) TTTCAC/TTGTTC 3 -- ut31 nc-transcript-variant0--------
    rs1877423151,2
    --171669339(+) TCACTA/CTGGAG 3 -- ut31 nc-transcript-variant0--------
    rs1924466911,2
    --171669423(+) ATTGAA/GAAGCT 3 -- ut31 nc-transcript-variant0--------
    rs1142381451,2
    C,F--171669632(+) ATGTAA/TTCTAC 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02WA 118
    rs1473011561,2
    C--171669742(+) TACAGG/TAGAAG 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for VAMP4 (171669296 - 171711387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VAMP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719529CNV Deletion23290073
    nsv3509CNV Insertion18451855
    esv28731CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606909    OMIM disorders: --

    4 diseases for VAMP4:    
    About MalaCards
    human granulocytic anaplasmosis    vesiculitis    ovarian cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for VAMP4:
    Human granulocytic anaplasmosis

    VAMP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VAMP4
    Human Genome Epidemiology (HuGE) Navigator: VAMP4 (1 document)

    Export disorders for VAMP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAMP4 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with VAMP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PubMed id 9553086)1, 2, 3 Advani R.J.... Scheller R.H. (J. Biol. Chem. 1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. (PubMed id 15896658)1, 4 Sabra M.M....Shuldiner A.R. (Mol. Genet. Metab. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PubMed id 11839770)1, 9 Mallard F....Johannes L. (J. Cell Biol. 2002)
    6. VAMP4 is required to maintain the ribbon structure of the Golgi apparatus. (PubMed id 23677696)1 Shitara A....Takuma T. (Mol. Cell. Biochem. 2013)
    7. Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation. (PubMed id 23741335)1 Sahlender D.A....Robinson M.S. (PLoS ONE 2013)
    8. Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion. (PubMed id 23798538)1 Kabeiseman E.J....Moore E.R. (Infect. Immun. 2013)
    9. ATP11B mediates platinum resistance in ovarian cancer. (PubMed id 23585472)1 Moreno-Smith M....Sood A.K. (J. Clin. Invest. 2013)
    10. VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. (PubMed id 22406549)1 Raingo J....Kavalali E.T. (Nat. Neurosci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8674 HGNC: 12645 AceView: VAMP4 Ensembl:ENSG00000117533 euGenes: HUgn8674
    ECgene: VAMP4 Kegg: 8674 H-InvDB: VAMP4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VAMP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VAMP4 gene:
    Search GeneIP for patents involving VAMP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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