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Aliases for VAMP4 Gene

Aliases for VAMP4 Gene

  • Vesicle-Associated Membrane Protein 4 2 3
  • VAMP-4 3 4
  • VAMP24 3

External Ids for VAMP4 Gene

Previous GeneCards Identifiers for VAMP4 Gene

  • GC01M169237
  • GC01M167298
  • GC01M168250
  • GC01M168908
  • GC01M168400
  • GC01M169935
  • GC01M171669
  • GC01M142893

Summaries for VAMP4 Gene

Entrez Gene Summary for VAMP4 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP4 Gene

VAMP4 (Vesicle-Associated Membrane Protein 4) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP4 Gene

  • Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule

Gene Wiki entry for VAMP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP4 Gene

Genomics for VAMP4 Gene

Regulatory Elements for VAMP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VAMP4 Gene

Chromosome:
1
Start:
171,700,156 bp from pter
End:
171,742,247 bp from pter
Size:
42,092 bases
Orientation:
Minus strand

Genomic View for VAMP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP4 Gene

Proteins for VAMP4 Gene

  • Protein details for VAMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75379-VAMP4_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 4
    Protein Accession:
    O75379
    Secondary Accessions:
    • A2IDD8
    • Q96IY9
    • Q96J20
    • Q9UEL7

    Protein attributes for VAMP4 Gene

    Size:
    141 amino acids
    Molecular mass:
    16397 Da
    Quaternary structure:
    • Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Alternative splice isoforms for VAMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAMP4 Gene

Proteomics data for VAMP4 Gene at MOPED

Post-translational modifications for VAMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP4 Gene

Antibody Products

No data available for DME Specific Peptides for VAMP4 Gene

Domains & Families for VAMP4 Gene

Gene Families for VAMP4 Gene

Protein Domains for VAMP4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75379

UniProtKB/Swiss-Prot:

VAMP4_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP4: view

Function for VAMP4 Gene

Molecular function for VAMP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule

Gene Ontology (GO) - Molecular Function for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with VAMP4: view

Phenotypes for VAMP4 Gene

GenomeRNAi human phenotypes for VAMP4:
genes like me logo Genes that share phenotypes with VAMP4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAMP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP4 Gene

Localization for VAMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP4 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP4 Gene COMPARTMENTS Subcellular localization image for VAMP4 gene
Compartment Confidence
golgi apparatus 5
endosome 4
lysosome 4
vacuole 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 9553086
GO:0005764 lysosome TAS 9553086
GO:0005768 endosome TAS 9553086
GO:0005794 Golgi apparatus IDA 23677696
GO:0005802 trans-Golgi network IEA --
genes like me logo Genes that share ontologies with VAMP4: view

Pathways & Interactions for VAMP4 Gene

genes like me logo Genes that share pathways with VAMP4: view

Pathways by source for VAMP4 Gene

1 KEGG pathway for VAMP4 Gene
1 GeneGo (Thomson Reuters) pathway for VAMP4 Gene

SIGNOR curated interactions for VAMP4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 23677696
GO:0006887 exocytosis IBA --
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP 23677696
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with VAMP4: view

Drugs & Compounds for VAMP4 Gene

(1) Drugs for VAMP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with VAMP4: view

Transcripts for VAMP4 Gene

Unigene Clusters for VAMP4 Gene

Vesicle-associated membrane protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAMP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for VAMP4 Gene

GeneLoc Exon Structure for
VAMP4
ECgene alternative splicing isoforms for
VAMP4

Expression for VAMP4 Gene

mRNA expression in normal human tissues for VAMP4 Gene

Protein differential expression in normal tissues from HIPED for VAMP4 Gene

This gene is overexpressed in Bone (26.9), Pancreas (7.2), Liver (6.5), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP4 Gene



SOURCE GeneReport for Unigene cluster for VAMP4 Gene Hs.6651

genes like me logo Genes that share expression patterns with VAMP4: view

Protein tissue co-expression partners for VAMP4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VAMP4 Gene

Orthologs for VAMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAMP4 35
  • 96.93 (n)
  • 98.58 (a)
VAMP4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp4 35
  • 94.72 (n)
  • 100 (a)
Vamp4 16
Vamp4 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP4 35
  • 100 (n)
  • 100 (a)
VAMP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp4 35
  • 94.17 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia VAMP4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAMP4 35
  • 78.72 (n)
  • 90.78 (a)
VAMP4 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP4 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp4 35
  • 77.07 (n)
  • 85.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12760 35
zebrafish
(Danio rerio)
Actinopterygii vamp4 35
  • 71.19 (n)
  • 78.57 (a)
zgc73166 35
vamp4 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snb-2 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 30 (a)
ManyToMany
SNC2 36
  • 30 (a)
ManyToMany
SNC2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5545 35
Species with no ortholog for VAMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP4 Gene

ENSEMBL:
Gene Tree for VAMP4 (if available)
TreeFam:
Gene Tree for VAMP4 (if available)

Paralogs for VAMP4 Gene

Paralogs for VAMP4 Gene

(7) SIMAP similar genes for VAMP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VAMP4: view

Variants for VAMP4 Gene

Sequence variations from dbSNP and Humsavar for VAMP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10903 -- 171,704,096(+) TTTCA(A/G)CATAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs15655 -- 171,704,132(+) TGACC(A/C)CCAGC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs236894 -- 171,700,683(+) ACTGT(A/G)GAGTC utr-variant-3-prime, nc-transcript-variant
rs236895 -- 171,703,419(+) TGTGT(G/T)TGTGT utr-variant-3-prime, intron-variant
rs236896 -- 171,703,473(+) TACAC(A/C)TAGGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAMP4 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
esv2719529 CNV Deletion 23290073
nsv3509 CNV Insertion 18451855

Variation tolerance for VAMP4 Gene

Residual Variation Intolerance Score: 51.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP4 Gene

HapMap Linkage Disequilibrium report
VAMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAMP4 Gene

Disorders for VAMP4 Gene

Relevant External Links for VAMP4

Genetic Association Database (GAD)
VAMP4
Human Genome Epidemiology (HuGE) Navigator
VAMP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP4
genes like me logo Genes that share disorders with VAMP4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VAMP4 Gene

Publications for VAMP4 Gene

  1. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PMID: 19620288) PAcrez-Victoria F.J. … Bonifacino J.S. (Mol. Cell. Biol. 2009) 23 67
  2. Docking of liposomes to planar surfaces mediated by trans-SNARE complexes. (PMID: 18424501) Vites O. … Jahn R. (Biophys. J. 2008) 23 67
  3. SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. (PMID: 17922004) BostrAPm P. … Olofsson S.O. (Nat. Cell Biol. 2007) 23 67
  4. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PMID: 11839770) Mallard F. … Johannes L. (J. Cell Biol. 2002) 23 67
  5. Biosynthesis and secretion of pituitary hormones: dynamics and regulation. (PMID: 11935396) Moore H.P. … Machen T.E. (Arch. Physiol. Biochem. 2002) 23 67

Products for VAMP4 Gene

Sources for VAMP4 Gene

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