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Aliases & Descriptions for VAMP3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CEB 1, 2, 3 | | Cellubrevin 3 | | OTTHUMP00000001361 2 | | SYB3 3 | | Synaptobrevin-3 3 | | VAMP-3 3 | | cellubrevin 2 | | synaptobrevin-3 2 |
| | | Descriptions |
|---|
| vesicle-associated membrane protein 3 2 | | vesicle-associated membrane protein 3 (cellubrevin) 2 |
|
| | Search outside databases for aliases for VAMP3 genePrevious GC identifers: GC01P007413 GC01P007640 GC01P007540 |
Summaries for VAMP3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VAMP3: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq] UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836Function: Trafficking protein from a constitutively recycling pathway (By similarity)Gene Wiki entry for VAMP3 |
Genomic Location for VAMP3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VAMP3 gene 
Entrez Gene cytogenetic band: 1p36.23 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.23VAMP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P007765:
(about GC identifiers)
Start:
|
7,753,916 bp from pter |
End:
|
7,770,120 bp from pter |
Size:
|
16,205 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_021937.18
| Proteins for VAMP3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836 (See
protein sequence)Recommended Name: Vesicle-associated membrane protein 3 Size: 100 amino acids; 11309 Da
Subcellular location: Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse, synaptosome (By similarity)Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004772.1
ENSEMBL proteins: ENSP00000054666 ENSP00000383702
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VAMP3: Assays for VAMP3: | Protein
Domains/ Families for VAMP3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15836
ProtoNet protein and cluster: Q15836 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836Similarity: Belongs to the synaptobrevin familySimilarity: Contains 1 v-SNARE coiled-coil homology domain | Gene Function for VAMP3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004781
Applied Biosystems Silencer® siRNAs for VAMP3
Sigma-Aldrich siRNA for VAMP3  Sigma-Aldrich shRNA for VAMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004781                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004781                                  untagged cDNA clone in CMV expression vector: NM_004781 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004781
UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836Function: Trafficking protein from a constitutively recycling pathway (By similarity)5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vamp3):
| Pathways & Interactions for VAMP3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for VAMP3 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for VAMP3 
5/30 Interacting proteins for VAMP3 (ENSP000000546663) via UniProtKB, MINT, and/or STRING (see all 30
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VAMP3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VAMP3 4 Novoseek chemical compound relationships for VAMP3 gene
About this table
|
Transcripts for VAMP3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004781
Sigma-Aldrich siRNA for VAMP3  Sigma-Aldrich shRNA for VAMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004781 REFSEQ mRNAs for VAMP3 gene: NM_004781.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004781               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004781                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004781                                  untagged cDNA clone in CMV expression vector: NM_004781  Additional cDNA sequence: AK316558.1 BC003570.1 BC005941.1 BC007050.1 BT007327.1 CR542145.1 CR542154.1 CR592566.1 CR608048.1 U64520.1 20 DOTS entries: DT.100669640 DT.418207 DT.121457264 DT.65284212 DT.92447521 DT.432301 DT.91638549 DT.100669638 DT.121457270 DT.121457287 DT.95250162 DT.101976203 DT.100669635 DT.121457275 DT.121457279 DT.121457300 DT.91725142 DT.92447525 DT.97859579 DT.121457267 24/422 AceView cDNA sequences (see all 422
):CB178674 BP337523 BP343779 BU622747 BM686501 CB123323 BI857932 AA599427 CR592566 BE786163 BM672733 AA255536 AW272871 BU629002 AA448635 AA564988 BQ066709 AL600765 BP360380 AI922222 BP354078 NM_004781 AU141864 BX502143
highest scoring ESTs for VAMP3:H93123 AA074764 AA074847 AA127319 AA127322 AA143196 AA143212 AA186537 AA195168 AA195268 Unigene Cluster for VAMP3: Vesicle-associated membrane protein 3 (cellubrevin) Hs.66708 [show with all ESTs]Unigene Representative Sequence: NM_004781
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | |   |
About this scheme
ECgene alternative splicing isoforms for VAMP3
2 Ensembl transcripts including schematic representations: ENST00000054666
ENST00000400911
|
Expression for VAMP3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VAMP3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VAMP3
1 / 2 / 3 8 probe-sets matching VAMP3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGAACCAGC
SOURCE GeneReport for Unigene cluster: Hs.66708
Expression variation in blood from EXPOLDB for VAMP3 |
Orthologs for VAMP3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VAMP3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for VAMP3
ENSEMBL Gene Tree for VAMP3 | Paralogs for VAMP3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VAMP3 gene
- VAMP22 VAMP12
|
SNPs/Variants for VAMP3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VAMP3 (up to first 250kb)
|
Disorders & Mutations for VAMP3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603657
2 Novoseek disease relationships for VAMP3 gene
About this table
Human Genome Epidemiology Navigator: VAMP3 (1 document)
|
Medical News for VAMP3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VAMP3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/90 PubMed articles for VAMP3 gene (see all 90
):- Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PubMed id 9885218)1, 2, 3, 4 Bernstein A.M. and Whiteheart S.W. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. (PubMed id 9396746)1, 3 Annaert W.G.... Jahn R. (1997)
- Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells. (PubMed id 11809765)1, 3 Poschet J.F....Deretic V. (2002)
- Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PubMed id 11839770)1, 3 Mallard F....Johannes L. (2002)
- A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (PubMed id 9614185)1, 3 Galli T....Louvard D. (1998)
- Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. (PubMed id 9701566)1, 3 Riento K....Olkkonen V.M. (1998)
- Silencing of VAMP3 inhibits cell migration and integrin-mediated adhesion. (PubMed id 19159614)3 Luftman K....Hu C. (2009)
|
Search for VAMP3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VAMP3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VAMP3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VAMP3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VAMP3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VAMP3:

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Incremental update: 13 Oct 2009
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