Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP3 Gene

protein-coding   GIFtS: 62
GCID: GC01P007765

Vesicle-Associated Membrane Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vesicle-Associated Membrane Protein 31 2     synaptobrevin-32
cellubrevin1 2     Cellubrevin3
CEB2 3     SYB33
VAMP-32 3     Synaptobrevin-33

External Ids:    HGNC: 126441   Entrez Gene: 93412   Ensembl: ENSG000000492457   OMIM: 6036575   UniProtKB: Q158363   

Export aliases for VAMP3 gene to outside databases

Previous GC identifers: GC01P007413 GC01P007640 GC01P007540 GC01P006979


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP3 Gene:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a
protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This
gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high
homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein
encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein
resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for VAMP3 Gene: 
VAMP3 (vesicle-associated membrane protein 3) is a protein-coding gene. Diseases associated with VAMP3 include tetanus, and tuberculosis, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein binding and syntaxin-1 binding. An important paralog of this gene is VAMP2.

UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836
Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

Gene Wiki entry for VAMP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP3 gene promoter:
         POU3F2 (N-Oct-5a)   CUTL1   Nkx2-5   POU3F2   NF-kappaB   FOXL1   POU2F1   POU2F1a   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

VAMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P007765:  view genomic region     (about GC identifiers)

Start:
7,831,329 bp from pter      End:
7,841,492 bp from pter
Size:
10,164 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 3  
Size: 100 amino acids; 11309 Da
Subunit: Interacts with BVES (via the C-terminus cytoplasmic tail) (By similarity)
Subcellular location: Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse,
synaptosome (By similarity)

Explore the universe of human proteins at neXtProt for VAMP3: NX_Q15836

Explore proteomics data for VAMP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15836

  • VAMP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VAMP3 Protein Expression
    REFSEQ proteins: NP_004772.1  
    ENSEMBL proteins: 
     ENSP00000054666   ENSP00000465820  

    Human Recombinant Protein Products for VAMP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for VAMP3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for VAMP3
    GenScript Custom Purified and Recombinant Proteins Services for VAMP3
    Novus Biologicals VAMP3 Proteins
    Novus Biologicals VAMP3 Lysate
    Sino Biological Recombinant Protein for VAMP3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for VAMP3
    Cloud-Clone Corp. Proteins for VAMP3 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030136clathrin-coated vesicle IDA19478182

    VAMP3 for ontologies           About GeneDecksing



    VAMP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VAMP3
    GenScript Custom Superior Antibodies Services for VAMP3
    Novus Biologicals VAMP3 Antibodies
    Abcam antibodies for VAMP3
    Cloud-Clone Corp. Antibodies for VAMP3 
    ThermoFisher Antibody for VAMP3
    LSBio Antibodies in human, mouse, rat for VAMP3 

    Assay Products for VAMP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VAMP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAMP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VAMP3 
    Cloud-Clone Corp. CLIAs for VAMP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VAMP: Vesicle-associated membrane proteins

    2 InterPro protein domains:
     IPR016444 Synaptobrevin_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry Q15836

    ProtoNet protein and cluster: Q15836

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP3_HUMAN, Q15836
    Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI19478182
    GO:0017075syntaxin-1 binding IEA--
         
    VAMP3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vamp3):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  normal 

    VAMP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vamp3tm1Jepn for VAMP3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VAMP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VAMP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAMP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAMP3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target VAMP3:
    hsa-mir-124 (MIRT002594), hsa-mir-155 (MIRT001487)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP3 (see all 40):
    hsa-miR-520f hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-3161 hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAMP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VAMP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAMP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VAMP3
    Sirion Biotech Customized adenovirus for overexpression of VAMP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VAMP3 (see all 7)
    OriGene ORF clones in mouse, rat for VAMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VAMP3 (NM_004781)
    Sino Biological Human cDNA Clone for VAMP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAMP3
    Sirion Biotech Customized lentivirus for stable overexpression of VAMP3 
                         Customized lentivirus expression plasmids for stable overexpression of VAMP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VAMP3
    Search LifeMap BioReagents cell lines for VAMP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAMP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Arf6 trafficking events
    Arf6 trafficking events
    4Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for VAMP3
        Epithelial Tight Junctions

    1 BioSystems Pathway for VAMP3
        Arf6 trafficking events


    1 PharmGKB Pathway for VAMP3
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2         Kegg Pathways  (Kegg details for VAMP3):
        SNARE interactions in vesicular transport
    Phagosome


    VAMP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for VAMP3 (Q158361, 2, 3 ENSP000000546664) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFEP186153, ENSP000003645784I2D: score=4 STRING: ENSP00000364578
    ENSG00000206268P186153I2D: score=4 
    ENSG00000206357P186153I2D: score=4 
    ENSG00000229363P186153I2D: score=4 
    ENSG00000231044P186153I2D: score=4 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001921positive regulation of receptor recycling ISS--
    GO:0006461protein complex assembly IEA--
    GO:0006887exocytosis TAS9885218
    GO:0006904vesicle docking involved in exocytosis TAS9885218
    GO:0016192vesicle-mediated transport ISS--

    VAMP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAMP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAMP3

    5 Novoseek inferred chemical compound relationships for VAMP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 28.9 1 9614185 (1)
    glucose 25.2 4 9153412 (2), 8862521 (1)
    phosphatidylinositol 3.93 1 12911814 (1)
    atp 0 1 8195285 (1)
    hydrogen 0 2 10807583 (2)

    Search CenterWatch for drugs/clinical trials and news about VAMP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAMP3 gene: 
    NM_004781.3  

    Unigene Cluster for VAMP3:

    Vesicle-associated membrane protein 3
    Hs.66708  [show with all ESTs]
    Unigene Representative Sequence: NM_004781
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000054666(uc001aol.3) ENST00000470357 ENST00000487194
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP3 (see all 40):
    hsa-miR-520f hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-3161 hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAMP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VAMP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAMP3
    Clone
    Products:
         
    OriGene clones in human, mouse for VAMP3 (see all 7)
    OriGene ORF clones in mouse, rat for VAMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VAMP3 (NM_004781)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAMP3
    Sirion Biotech Customized lentivirus for stable overexpression of VAMP3 
                         Customized lentivirus expression plasmids for stable overexpression of VAMP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VAMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for VAMP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAMP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAMP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP3

    Additional mRNA sequence: 

    AK316558.1 BC003570.1 BC005941.1 BC007050.1 BT007327.1 CR542145.1 CR542154.1 U64520.1 

    20 DOTS entries:

    DT.100669640  DT.418207  DT.121457264  DT.65284212  DT.92447521  DT.432301  DT.100669638  DT.121457270 
    DT.121457287  DT.91638549  DT.95250162  DT.101976203  DT.121457279  DT.100669635  DT.121457275  DT.121457300 
    DT.91725142  DT.92447525  DT.97859579  DT.121457267 

    24/422 AceView cDNA sequences (see all 422):

    BP348567 BM672733 BP356436 AU137465 NM_004781 BM457217 BQ066709 AU141864 
    BM699405 AU103688 BU622747 BC003570 CA435742 CB162873 CF138786 BG057129 
    AA448635 BP335731 AA143196 CD742937 CR542145 BM765660 AA600094 AA582812 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:                    -     -     -     -           -                                 
    SP2:                    -           -     -           -                                 
    SP3:                                -     -           -                                 
    SP4:                                                  -                                 
    SP5:                    -     -     -     -           -     -     -     -     -         


    ECgene alternative splicing isoforms for VAMP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAACCAGC
    VAMP3 Expression
    About this image


    See VAMP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAMP3

    SOURCE GeneReport for Unigene cluster: Hs.66708
        SABiosciences Expression via Pathway-Focused PCR Array including VAMP3: 
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VAMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for VAMP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VAMP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAMP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP3 gene from 8/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp31 , 5 vesicle-associated membrane protein 31, 5 85.91(n)1
    92.78(a)1
      4 (81.53 cM)5
    223191  NM_009498.41  NP_033524.11 
     1510473005 
    chicken
    (Gallus gallus)
    Aves VAMP31 vesicle-associated membrane protein 3 (cellubrevin) 78.89(n)
    92.22(a)
      419368  NM_001039489.1  NP_001034578.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP36
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL344178.1(48009-49839)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165072 Xenopus laevis transcribed sequence with moderate similarity more 78.65(n)    CF270539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vamp31 vesicle-associated membrane protein 3 (cellubrevin) 75.09(n)
    85.71(a)
      415163  NM_001002073.1  NP_001002073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syb6
    n-syb6
    n-synaptobrevin
    35(a)
    28(a)
    many ↔ many
    many ↔ many
    2R(6136940-6139914)
    3L(1630348-1637752)
    worm
    (Caenorhabditis elegans)
    Secernentea snb-11 Protein SNB-1 67.44(n)
    76.74(a)
      266648  NM_072287.3  NP_504688.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NYV1(YLR093C)4 v-SNARE component of the vacuolar SNARE complex involved more   --   12(327415-326513) 850782  NP_013194.2 


    ENSEMBL Gene Tree for VAMP3 (if available)
    TreeFam Gene Tree for VAMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP3 gene
    VAMP22  VAMP12  VAMP82  VAMP42  ENSG000002636202  
    6 SIMAP similar genes for VAMP3 using alignment to 4 protein entries:     VAMP3_HUMAN (see all proteins):
    VAMP1    VAMP2    VAMP4    VAMP8    VAMP5    SYBL1

    VAMP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 SNPs in VAMP3 are shown (see all 262)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728538881,2
    C,F--7830335(+) TTTTCA/CCTTGT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1893339221,2
    --7830393(+) CACTGC/TTGTCT 1 -- us2k10--------
    rs2017544051,2
    C--7830447(+) CCACT-/AGTACC 1 -- us2k10--------
    rs768419381,2
    C,F--7830850(+) AAAACA/GTGAGC 1 -- us2k12Minor allele frequency- G:0.02CSA WA 120
    rs1813925691,2
    --7830881(+) TGTGAC/TAAATA 1 -- us2k10--------
    rs7074571,2
    C,F,A,H--7831064(-) CACTGG/TCGAGG 1 -- us2k121Minor allele frequency- T:0.09MN NS EA NA WA 2530
    rs1154472281,2
    C,F--7831219(+) CGTCCG/CGGGAG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs728538891,2
    C,F--7831352(+) CGCCGA/C/TGCCGT 2 -- ut512WA EA 238
    rs1859232611,2
    --7831547(+) GGACGC/GAGGCC 1 -- int10--------
    rs115827991,2
    C,F,H--7832026(+) CTCTTC/TCACCT 1 -- int1 trp33Minor allele frequency- T:0.09CSA WA NA 240

    HapMap Linkage Disequilibrium report for VAMP3 (7831329 - 7841492 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VAMP3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VAMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for VAMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603657    OMIM disorders: --

    8 diseases for VAMP3:    About MalaCards
    tetanus    tuberculosis    crohn's disease    cystic fibrosis
    endotheliitis    melanoma    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for VAMP3:
    Tetanus

    VAMP3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for VAMP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 79.7 37 8195285 (4), 8360142 (4), 10807583 (3), 10888677 (2) (see all 20)
    tuberculosis 0 1 11825909 (1)

    Genetic Association Database (GAD): VAMP3
    Human Genome Epidemiology (HuGE) Navigator: VAMP3 (2 documents)

    Export disorders for VAMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP3 gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with VAMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PubMed id 9885218)1, 2, 3, 9 Bernstein A.M. and Whiteheart S.W. (1999)
    2. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    3. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2 Ganley I.G....Pfeffer S.R. (2008)
    4. Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (PubMed id 18628682)1, 4 Abou Jamra R....Schumacher J. (2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. (PubMed id 9396746)1, 9 Annaert W.G.... Jahn R. (1997)
    9. VAMP3, syntaxin-13 and SNAP23 are involved in secreti on of matrix metalloproteinases, degradation of the extracellular matrix and ce ll invasion. (PubMed id 19910495)1, 9 Kean M.J....Coppolino M.G. (2009)
    10. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE prot eins involved in specific steps of the autophagy/multivesicular body pathways. (PubMed id 19781582)1, 9 Fader C.M....Colombo M.I. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9341 HGNC: 12644 AceView: VAMP3 Ensembl:ENSG00000049245 euGenes: HUgn9341
    ECgene: VAMP3 Kegg: 9341 H-InvDB: VAMP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAMP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAMP3 gene:
    Search GeneIP for patents involving VAMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VAMP3  
     OriGene qPCR primer pairs and template standards for VAMP3   OriGene Protein Over-expression Lysate for VAMP3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VAMP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for VAMP3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for VAMP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VAMP3   OriGene Custom Protein Services for VAMP3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VAMP3
     QIAGEN SeqTarget long-range PCR primers for resequencing VAMP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAMP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VAMP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VAMP3
     GenScript Custom Purified and Recombinant Proteins Services for VAMP3 GenScript cDNA clones with any tag delivered in your preferred vector for VAMP3
     GenScript Custom Assay Services for VAMP3 GenScript Custom Superior Antibodies Services for VAMP3
     GenScript Custom overexpressing Cell Line Services for VAMP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VAMP3 promoter
     Search Chromatin IP Primers for VAMP3
     RT2 qPCR Primer Assay in human, mouse, rat VAMP3
     GNC Network for VAMP3
     SABiosciences PCR Arrays including human, mouse, rat VAMP3
     Search Tocris compounds for VAMP3
     Proteins and Antibodies for VAMP3
     Browse Sino Biological Cell Lysates
     cDNA Clones for VAMP3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VAMP3 antibodies
     VAMP3 proteins
     VAMP3 lysates
     Antibodies for VAMP3
     See all of Abcam's Antibodies, Kits and Proteins for VAMP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for VAMP3




     Proteins for VAMP3
     Antibodies for VAMP3
     ELISAs for VAMP3
     CLIAs for VAMP3
     Search LifeMap BioReagents cell lines for VAMP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP3
     SwitchGear 3'UTR luciferase reporter plasmids for VAMP3
     SwitchGear Promoter luciferase reporter plasmids for VAMP3
     ThermoFisher Antibody for VAMP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAMP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for VAMP3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VAMP3
    Customized:
     lentivirus for stable overexpression of VAMP3
     lentivirus expression plasmids for stable overexpression of VAMP3
     adenovirus for overexpression of VAMP3
     LSBio Antibodies in human, mouse, rat for VAMP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VAMP3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4