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VAMP3 Gene

protein-coding   GIFtS: 62
GCID: GC01P007765

Vesicle-Associated Membrane Protein 3

  See VAMP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vesicle-Associated Membrane Protein 31 2     synaptobrevin-32
cellubrevin1 2     Cellubrevin3
CEB2 3     SYB33
VAMP-32 3     Synaptobrevin-33

External Ids:    HGNC: 126441   Entrez Gene: 93412   Ensembl: ENSG000000492457   OMIM: 6036575   UniProtKB: Q158363   

Export aliases for VAMP3 gene to outside databases

Previous GC identifers: GC01P007413 GC01P007640 GC01P007540 GC01P006979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VAMP3 Gene:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a
protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This
gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high
homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein
encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein
resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for VAMP3 Gene:
VAMP3 (vesicle-associated membrane protein 3) is a protein-coding gene. Diseases associated with VAMP3 include tetanus. GO annotations related to this gene include syntaxin-1 binding. An important paralog of this gene is VAMP2.

UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836
Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

Gene Wiki entry for VAMP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAMP3 gene promoter:
         POU3F2 (N-Oct-5a)   CUTL1   Nkx2-5   POU3F2   NF-kappaB   FOXL1   POU2F1   POU2F1a   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP3 promoter sequence
   Search Chromatin IP Primers for VAMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

VAMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P007765:  view genomic region     (about GC identifiers)

Start:
7,831,329 bp from pter      End:
7,841,492 bp from pter
Size:
10,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 3  
Size: 100 amino acids; 11309 Da
Subunit: Interacts with BVES (via the C-terminus cytoplasmic tail) (By similarity)
Secondary accessions: Q9BRV4

Explore the universe of human proteins at neXtProt for VAMP3: NX_Q15836

Explore proteomics data for VAMP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys66, Lys68
  • Modification sites at PhosphoSitePlus

  • See VAMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004772.1  
    ENSEMBL proteins: 
     ENSP00000054666   ENSP00000465820  

    VAMP3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for VAMP3

     
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    antibodies-online proteins for VAMP3 (16 products) 

     
    antibodies-online peptides for VAMP3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VAMP: Vesicle-associated membrane proteins

    3 InterPro protein domains:
     IPR016444 Synaptobrevin/VAMP_met/fun
     IPR001388 Synaptobrevin
     IPR028706 VAMP3

    Graphical View of Domain Structure for InterPro Entry Q15836

    ProtoNet protein and cluster: Q15836

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP3_HUMAN, Q15836
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Find genes that share domains with VAMP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP3_HUMAN, Q15836
    Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding IPI19478182
    GO:0017075syntaxin-1 binding IEA--
         
    Find genes that share ontologies with VAMP3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vamp3):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  normal 

    Find genes that share phenotypes with VAMP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vamp3tm1Jepn for VAMP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAMP3
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    miRNA
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    miRTarBase miRNAs that target VAMP3:
    hsa-mir-19b-3p (MIRT031281), hsa-mir-98-5p (MIRT027733), hsa-mir-124-3p (MIRT002594), hsa-let-7b-5p (MIRT032396), hsa-mir-155-5p (MIRT001487), hsa-mir-30a-5p (MIRT028609)

    Block miRNA regulation of human, mouse, rat VAMP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VAMP3 (see all 40):
    hsa-miR-520f hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-3161 hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidVAMP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VAMP3_HUMAN, Q15836: Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse,
    synaptosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane4
    cytosol3
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0008021synaptic vesicle IBA--
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with VAMP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VAMP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Phagosome
    Phagosome
    4Arf6 trafficking events
    Arf6 trafficking events


    Find genes that share SuperPaths with VAMP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for VAMP3
        Epithelial Tight Junctions

    1 BioSystems Pathway for VAMP3
        Arf6 trafficking events


    1 PharmGKB Pathway for VAMP3
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for VAMP3):
        SNARE interactions in vesicular transport
    Phagosome

        Pathway & Disease-focused RT2 Profiler PCR Array including VAMP3: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VAMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAMP3 (Q158361, 2, 3 ENSP000000546664) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFEP186153, ENSP000003645784I2D: score=4 STRING: ENSP00000364578
    ENSG00000206268P186153I2D: score=4 
    ENSG00000206357P186153I2D: score=4 
    ENSG00000229363P186153I2D: score=4 
    ENSG00000231044P186153I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001921positive regulation of receptor recycling ISS--
    GO:0006461protein complex assembly IEA--
    GO:0006887exocytosis TAS9885218
    GO:0006904vesicle docking involved in exocytosis TAS9885218
    GO:0006906vesicle fusion IBA--

    Find genes that share ontologies with VAMP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAMP3

    5 Novoseek inferred chemical compound relationships for VAMP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 28.9 1 9614185 (1)
    glucose 25.2 4 9153412 (2), 8862521 (1)
    phosphatidylinositol 3.93 1 12911814 (1)
    atp 0 1 8195285 (1)
    hydrogen 0 2 10807583 (2)



    Find genes that share compounds with VAMP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VAMP3 gene: 
    NM_004781.3  

    Unigene Cluster for VAMP3:

    Vesicle-associated membrane protein 3
    Hs.66708  [show with all ESTs]
    Unigene Representative Sequence: NM_004781
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000054666(uc001aol.3) ENST00000470357 ENST00000487194
    miRNA
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    hsa-miR-520f hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-3161 hsa-miR-9 hsa-miR-30a
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    Additional mRNA sequence: 

    AK316558.1 BC003570.1 BC005941.1 BC007050.1 BT007327.1 CR542145.1 CR542154.1 U64520.1 

    20 DOTS entries:

    DT.100669640  DT.418207  DT.121457264  DT.65284212  DT.92447521  DT.432301  DT.100669638  DT.121457270 
    DT.121457287  DT.91638549  DT.95250162  DT.101976203  DT.121457279  DT.100669635  DT.121457275  DT.121457300 
    DT.91725142  DT.92447525  DT.97859579  DT.121457267 

    Selected AceView cDNA sequences (see all 422):

    AA668212 BM672733 BP336344 BM772043 BQ066709 CA420324 CD515764 BM829743 
    BP337038 BP360380 CB162873 BU629002 CB178674 BM834680 BM787883 AI579940 
    BQ029103 AU103697 AW469283 AU141864 BU622747 AA418516 BG057129 AW008154 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:                    -     -     -     -           -                                 
    SP2:                    -           -     -           -                                 
    SP3:                                -     -           -                                 
    SP4:                                                  -                                 
    SP5:                    -     -     -     -           -     -     -     -     -         


    ECgene alternative splicing isoforms for VAMP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VAMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAACCAGC
    VAMP3 Expression
    About this image

    VAMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.66708
        Pathway & Disease-focused RT2 Profiler PCR Array including VAMP3: 
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp31 , 5 vesicle-associated membrane protein 31, 5 86.18(n)1
    93.9(a)1
      4 (81.53 cM)5
    223191  NM_009498.41  NP_033524.11 
     1510473005 
    chicken
    (Gallus gallus)
    Aves VAMP31 vesicle-associated membrane protein 3 (cellubrevin) 82.41(n)
    98.61(a)
      419368  NM_001039489.1  NP_001034578.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP36
    vesicle-associated membrane protein 3
    82(a)
    1 ↔ 1
    GL344178.1(48009-49839)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165072 Xenopus laevis transcribed sequence with moderate similarity more 78.65(n)    CF270539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vamp31 vesicle-associated membrane protein 3 (cellubrevin) 76.32(n)
    90.79(a)
      415163  NM_001002073.1  NP_001002073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syb6
    n-syb6
    n-synaptobrevin
    36(a)
    28(a)
    many ↔ many
    many ↔ many
    2R(6136940-6139914)
    3L(1630348-1637752)
    worm
    (Caenorhabditis elegans)
    Secernentea snb-16
    Protein SNB-1 (snb-1) mRNA, complete cds
    61(a)
    1 → many
    V(6655551-6656501) WBGene00004897
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NYV1(YLR093C)4 v-SNARE component of the vacuolar SNARE complex involved more   --   12(327415-326513) 850782  NP_013194.2 


    ENSEMBL Gene Tree for VAMP3 (if available)
    TreeFam Gene Tree for VAMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VAMP3 gene
    VAMP22  VAMP12  VAMP82  VAMP42  ENSG000002636202  
    6 SIMAP similar genes for VAMP3 using alignment to 3 protein entries:     VAMP3_HUMAN (see all proteins):
    VAMP1    VAMP2    VAMP4    VAMP8    VAMP5    SYBL1

    Find genes that share paralogs with VAMP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VAMP3 (see all 262)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728538881,2
    C,F--7830335(+) TTTTCA/CCTTGT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1893339221,2
    --7830393(+) CACTGC/TTGTCT 1 -- us2k10--------
    rs2017544051,2
    C--7830447(+) CCACT-/AGTACC 1 -- us2k10--------
    rs768419381,2
    C,F--7830850(+) AAAACA/GTGAGC 1 -- us2k12Minor allele frequency- G:0.02CSA WA 120
    rs1813925691,2
    --7830881(+) TGTGAC/TAAATA 1 -- us2k10--------
    rs7074571,2
    C,F,A,H--7831064(-) CACTGG/TCGAGG 1 -- us2k121Minor allele frequency- T:0.09MN NS EA NA WA 2530
    rs1154472281,2
    C,F--7831219(+) CGTCCG/CGGGAG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs728538891,2
    C,F--7831352(+) CGCCGA/C/TGCCGT 2 -- ut512WA EA 238
    rs1859232611,2
    --7831547(+) GGACGC/GAGGCC 1 -- int10--------
    rs115827991,2
    C,F,H--7832026(+) CTCTTC/TCACCT 1 -- int1 trp33Minor allele frequency- T:0.09CSA WA NA 240

    HapMap Linkage Disequilibrium report for VAMP3 (7831329 - 7841492 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VAMP3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for VAMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603657    OMIM disorders: --

    1 disease for VAMP3:    
    About MalaCards
    tetanus

    1 disease from the University of Copenhagen DISEASES database for VAMP3:
    Tetanus

    Find genes that share disorders with VAMP3           About GenesLikeMe

    2 Novoseek inferred disease relationships for VAMP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 79.7 37 8195285 (4), 8360142 (4), 10807583 (3), 10888677 (2) (see all 20)
    tuberculosis 0 1 11825909 (1)

    Genetic Association Database (GAD): VAMP3
    Human Genome Epidemiology (HuGE) Navigator: VAMP3 (2 documents)

    Export disorders for VAMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VAMP3 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with VAMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PubMed id 9885218)1, 2, 3, 9 Bernstein A.M. and Whiteheart S.W. (Blood 1999)
    2. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    3. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2 Ganley I.G.... Pfeffer S.R. (J. Cell Biol. 2008)
    4. Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (PubMed id 18628682)1, 4 Abou Jamra R....Schumacher J. (Psychiatr. Genet. 2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. (PubMed id 9396746)1, 9 Annaert W.G.... Jahn R. (J. Cell Biol. 1997)
    9. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PubMed id 19910495)1, 9 Kean M.J....Coppolino M.G. (J. Cell. Sci. 2009)
    10. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. (PubMed id 19781582)1, 9 Fader C.M....Colombo M.I. (Biochim. Biophys. Acta 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9341 HGNC: 12644 AceView: VAMP3 Ensembl:ENSG00000049245 euGenes: HUgn9341
    ECgene: VAMP3 Kegg: 9341 H-InvDB: VAMP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VAMP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAMP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VAMP3 gene:
    Search GeneIP for patents involving VAMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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