Aliases for VAMP2 Gene
External Ids for VAMP2 Gene
Previous HGNC Symbols for VAMP2 Gene
Previous GeneCards Identifiers for VAMP2 Gene
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP2 Gene
VAMP2 (Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2)) is a Protein Coding gene. Diseases associated with VAMP2 include tetanus and botulism. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is VAMP3.
UniProtKB/Swiss-Prot for VAMP2 Gene
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.