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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP2 Gene

protein-coding   GIFtS: 68
GCID: GC17M008062

Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2)


(Previous symbol: SYB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2)1 2     synaptobrevin-22
SYB21 2 3 5     Vesicle Associated Membrane Protein 22
VAMP-22 3     Vesicle-Associated Membrane Protein 22
Synaptobrevin 22     Synaptobrevin-23

External Ids:    HGNC: 126431   Entrez Gene: 68442   Ensembl: ENSG000002202057   OMIM: 1858815   UniProtKB: P630273   

Export aliases for VAMP2 gene to outside databases

Previous GC identifers: GC17U990100 GC17M009150 GC17M008005 GC17M008263 GC17M007987 GC17M008054 GC17M007957


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP2 Gene:
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin
family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main
components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic
membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion.
The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It
also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia
(FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been
implicated in the pathogenesis of FIMG. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAMP2 Gene: 
VAMP2 (vesicle-associated membrane protein 2 (synaptobrevin 2)) is a protein-coding gene. Diseases associated with VAMP2 include tetanus, and botulism, and among its related super-pathways are Serotonin Neurotransmitter Release Cycle and Clathrin-dependent protein traffic. GO annotations related to this gene include protein binding. An important paralog of this gene is VAMP1.

UniProtKB/Swiss-Prot: VAMP2_HUMAN, P63027
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Wiki entry for VAMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP2 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   AP-1   ATF-2   E2F-2   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

VAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008062:  view genomic region     (about GC identifiers)

Start:
8,062,465 bp from pter      End:
8,066,864 bp from pter
Size:
4,400 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAMP2_HUMAN, P63027 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 2  
Size: 116 amino acids; 12663 Da
Subunit: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts
with BVES and STX4 (By similarity). Interacts with VAPA and VAPB
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV
membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles
5 PDB 3D structures from and Proteopedia for VAMP2:
3FIE (3D)        3FII (3D)        3RK2 (3D)        3RK3 (3D)        3RL0 (3D)    
Secondary accessions: P19065 Q9BUC2

Explore the universe of human proteins at neXtProt for VAMP2: NX_P63027

Explore proteomics data for VAMP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63027

  • VAMP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VAMP2 Protein Expression
    REFSEQ proteins: NP_055047.2  
    ENSEMBL proteins: 
     ENSP00000314214   ENSP00000466995   ENSP00000418572   ENSP00000467399  
    Reactome Protein details: P63027
    Human Recombinant Protein Products for VAMP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for VAMP2
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    Novus Biologicals VAMP2 Proteins
    Novus Biologicals VAMP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for VAMP2
    Cloud-Clone Corp. Proteins for VAMP2 

    Gene Ontology (GO): 5/25 cellular component terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802trans-Golgi network IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1976629
    GO:0008021synaptic vesicle ----
    GO:0016020membrane IDA--

    VAMP2 for ontologies           About GeneDecksing



    VAMP2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for VAMP2 

    Assay Products for VAMP2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VAMP: Vesicle-associated membrane proteins

    2 InterPro protein domains:
     IPR016444 Synaptobrevin_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry P63027

    ProtoNet protein and cluster: P63027

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP2_HUMAN, P63027
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP2_HUMAN, P63027
    Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

         Genatlas biochemistry entry for VAMP2:
    vesicule associated membrane protein 2,synaptobrevin 2,expressed in neurons forming a synaptic core complex with
    syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N
    ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI17196367
    GO:0005516calmodulin binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008022protein C-terminus binding IEA--
         
    VAMP2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vamp2):
     endocrine/exocrine gland  growth/size  hematopoietic system  immune system  mortality/aging 
     nervous system  normal 

    VAMP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vamp2tm1Sud for VAMP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VAMP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VAMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAMP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAMP2 

    miRNA
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    miRTarBase miRNAs that target VAMP2:
    hsa-mir-34a (MIRT001758)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VAMP2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate VAMP2 (see all 59):
    hsa-miR-330-5p hsa-miR-765 hsa-let-7a-2* hsa-miR-486-3p hsa-miR-628-3p hsa-miR-374a hsa-miR-449a hsa-miR-3923
    SwitchGear 3'UTR luciferase reporter plasmidVAMP2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAMP2 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Serotonin Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.60
    Acetylcholine Neurotransmitter Release Cycle0.53
    Dopamine Neurotransmitter Release Cycle0.60
    Glutamate Neurotransmitter Release Cycle0.44
    Norepinephrine Neurotransmitter Release Cycle0.60
    Effects of Botulinum toxin0.43
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    3Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    5Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for VAMP2
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for VAMP2
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for VAMP2
        Neuroscience

    4 GeneGo (Thomson Reuters) Pathways for VAMP2
        Normal wtCFTR traffic / Sorting endosome formation
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF
    Transport Clathrin-coated vesicle cycle

    5 BioSystems Pathways for VAMP2
        Insulin Signaling
    SIDS Susceptibility Pathways
    Synaptic Vesicle Pathway
    Effects of Botulinum toxin
    Insulin-mediated glucose transport


    5/25        Reactome Pathways for VAMP2 (see all 25)
        Proteolytic cleavage of SNARE complex proteins
    Membrane Trafficking
    Transmission across Chemical Synapses
    Clathrin derived vesicle budding
    Metabolism

    1 PharmGKB Pathway for VAMP2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    5         Kegg Pathways  (Kegg details for VAMP2):
        SNARE interactions in vesicular transport
    Synaptic vesicle cycle
    Insulin secretion
    Vasopressin-regulated water reabsorption
    Salivary secretion


    VAMP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/109 Interacting proteins for VAMP2 (P630271, 2, 3 ENSP000003142144) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKD3O948061, 3, ENSP000002341794EBI-520113,EBI-1255366 I2D: score=2 STRING: ENSP00000234179
    STX1BP612663, ENSP000002150954I2D: score=5 STRING: ENSP00000215095
    STX4Q128463, ENSP000003177144I2D: score=4 STRING: ENSP00000317714
    SYPL1Q165633, ENSP000000114734I2D: score=2 STRING: ENSP00000011473
    DNAJC5Q9H3Z43, ENSP000003541114I2D: score=1 STRING: ENSP00000354111
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006461protein complex assembly IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--

    VAMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAMP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAMP2

    1 DrugBank Compound for VAMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type BBotulinum neurotoxin type B precursor (see all 2)93384-44-2targetbinder11752352 14573702

    10/16 Novoseek inferred chemical compound relationships for VAMP2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 50.9 2 15256361 (1), 11522683 (1)
    glucose 38.9 13 15537656 (3), 8772493 (2), 10713150 (1), 11208137 (1) (see all 9)
    phosphatidylinositol 19.6 1 11297538 (1)
    phorbol 16.9 2 11162495 (1), 11263991 (1)
    glutamate 10.5 4 9765296 (1), 15028755 (1), 16018556 (1)
    calcium 3.9 4 15846778 (1), 18715899 (1), 17204559 (1), 15028755 (1)
    acetylcholine 2.47 3 8900203 (1), 10496269 (1), 16018556 (1)
    lipid 0 4 15073181 (1), 16439800 (1), 19812247 (1), 12376543 (1)
    tyrosine 0 1 16018556 (1)
    hydrogen 0 1 17311420 (1)

    Search CenterWatch for drugs/clinical trials and news about VAMP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAMP2 gene: 
    NM_014232.2  

    Unigene Cluster for VAMP2:

    Vesicle-associated membrane protein 2 (synaptobrevin 2)
    Hs.25348  [show with all ESTs]
    Unigene Representative Sequence: NM_014232
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316509(uc010cnt.1) ENST00000404970 ENST00000488857 ENST00000481878

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    Additional mRNA sequence: 

    AJ225044.1 AK021522.1 AK225777.1 AK289555.1 AL050223.1 BC002737.2 BC019608.1 BC033870.1 
    BC150138.1 

    15 DOTS entries:

    DT.40107989  DT.100794299  DT.448468  DT.91787682  DT.95353896  DT.65287860  DT.100794300  DT.100794301 
    DT.95149295  DT.98081774  DT.75161839  DT.75180389  DT.91766472  DT.92426527  DT.95170329 

    24/455 AceView cDNA sequences (see all 455):

    AW614390 H83576 F04440 H27871 CD514276 BM671785 BM668991 AI220523 
    BX508108 BP352132 BM709155 AA909154 CK819778 CB270623 CK819779 BU726580 
    AA416621 BE702581 AI538211 AK021522 H92470 BM666630 AA971398 BU949704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP2 expression in normal human tissues (normalized intensities)      VAMP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCAATTC
    VAMP2 Expression
    About this image


    VAMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See VAMP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VAMP2

    SOURCE GeneReport for Unigene cluster: Hs.25348

    UniProtKB/Swiss-Prot: VAMP2_HUMAN, P63027
    Tissue specificity: Nervous system and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp21 , 5 vesicle-associated membrane protein 21, 5 94.25(n)1
    99.14(a)1
      11 (42.36 cM)5
    223181  NM_009497.31  NP_033523.11 
     690884905 
    chicken
    (Gallus gallus)
    Aves VAMP21 vesicle-associated membrane protein 2 (synaptobrevin more 73.68(n)
    80.7(a)
      424827  XM_422640.3  XP_422640.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    97(a)
    79(a)
    1 ↔ many
    possible ortholog
    GL343400.1(482410-485981)
    3(27975761-27985819)
    African clawed frog
    (Xenopus laevis)
    Amphibia vamp2-B-prov2 vesicle-associated membrane protein 2 (synaptobrevin more 81.31(n)    AF035017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059687.12   -- 78.1(n)    BC059687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syb1 Synaptobrevin 72.53(n)
    72.53(a)
      36080  NM_001144161.1  NP_001137633.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snb-16
    snb-26
    Protein SNB-2
    65(a)
    43(a)
    many ↔ many
    many ↔ many
    V(6655551-6656501)
    V(12344186-12345919)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNC1(YAL030W)4 Vesicle membrane receptor protein (v-SNARE) involved more   --   1(87286-87752) 851203  NP_009372.1 


    ENSEMBL Gene Tree for VAMP2 (if available)
    TreeFam Gene Tree for VAMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP2 gene
    VAMP12  VAMP82  VAMP32  VAMP42  ENSG000002636202  
    6 SIMAP similar genes for VAMP2 using alignment to 4 protein entries:     VAMP2_HUMAN (see all proteins):
    VAMP1    VAMP3    VAMP8    VAMP4    VAMP5    SYBL1

    VAMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/144 SNPs in VAMP2 are shown (see all 144)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157141911,2
    C,F--8062092(+) CTGCAC/TGGGAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1479406811,2
    C--8062093(+) TGCACA/GGGAGC 1 -- ds50010--------
    rs22786371,2
    C,F,A,H--8062102(+) GCCACT/GGCAGA 1 -- ds500125Minor allele frequency- G:0.43EA NS NA WA CSA 3812
    rs1164049831,2
    C,F--8062125(+) TAAATC/AGAGGA 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1811892331,2
    --8062129(+) TCGAGA/GAGTAG 1 -- ds50010--------
    rs9593031,2
    C,F,A,H--8062199(+) GACCAT/CAGGGC 1 -- ds500127Minor allele frequency- C:0.42MN EA NS NA WA CSA 3834
    rs1401369811,2
    C--8062216(+) GGCTT-/AGAGACA 1 -- ds50010--------
    rs803496091,2
    F--8062239(+) TGACAC/GTTCCC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs796349901,2
    F--8062267(+) CCCCCC/GTGTGG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1851892931,2
    --8062299(+) GCCCTC/GCCCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for VAMP2 (8062465 - 8066864 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VAMP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1964CNV Insertion18451855
    nsv527475CNV Loss19592680
    nsv833353CNV Loss17160897
    nsv907658CNV Loss21882294
    dgv3056n71CNV Loss21882294
    nsv833352CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 185881    OMIM disorders: --

    14 diseases for VAMP2:    About MalaCards
    tetanus    botulism    vesiculitis    insulinoma
    type 1 diabetes    mental retardation    alcoholism    schizophrenia
    hypertension    myeloid leukemia    melanoma    neuronitis
    pancreatitis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for VAMP2:
    Tetanus     Botulism

    VAMP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for VAMP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 78.7 47 11068046 (3), 10888677 (2), 7560075 (2), 18511417 (2) (see all 31)
    insulinoma 11.9 2 12887316 (1), 11502551 (1)

    Genetic Association Database (GAD): VAMP2
    Human Genome Epidemiology (HuGE) Navigator: VAMP2 (6 documents)

    Export disorders for VAMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP2 gene, integrated from 9 sources (see all 275):
    (articles sorted by number of sources associating them with VAMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PubMed id 1976629)1, 2, 3, 9 Archer B.T. III... Suedhof T.C. (1990)
    2. Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (PubMed id 18628682)1, 4, 9 Abou Jamra R....Schumacher J. (2008)
    3. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. (PubMed id 18512733)1, 4, 9 Kawashima K....Iwata N. (2008)
    4. Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients. (PubMed id 17356306)1, 4, 9 Saito S....Ozaki N. (2006)
    5. De novo STXBP1 mutations in mental retardation and no nsyndromic epilepsy. (PubMed id 19557857)1, 4, 9 Hamdan F.F....Michaud J.L. (2009)
    6. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 2, 9 Jagadish M.N....Ward C.W. (1996)
    7. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. (PubMed id 7835332)1, 2 Kutay U.... Rapoport T.A. (1995)
    10. Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin. (PubMed id 18511417)1, 9 Chen S....Barbieri J.T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6844 HGNC: 12643 AceView: VAMP2 Ensembl:ENSG00000220205 euGenes: HUgn6844
    ECgene: VAMP2 Kegg: 6844 H-InvDB: VAMP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAMP2 gene:
    Search GeneIP for patents involving VAMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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