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Aliases for VAMP2 Gene

Aliases for VAMP2 Gene

  • Vesicle Associated Membrane Protein 2 2 3 5
  • Synaptobrevin 2 2 3
  • VAMP-2 3 4
  • SYB2 3 4
  • Vesicle-Associated Membrane Protein 2 3
  • Synaptobrevin-2 4

External Ids for VAMP2 Gene

Previous HGNC Symbols for VAMP2 Gene

  • SYB2

Previous GeneCards Identifiers for VAMP2 Gene

  • GC17U990100
  • GC17M009150
  • GC17M008005
  • GC17M008263
  • GC17M007987
  • GC17M008054
  • GC17M007957
  • GC17M008062
  • GC17M008165
  • GC17M008219
  • GC17M008270
  • GC17M008335
  • GC17M008366
  • GC17M008405

Summaries for VAMP2 Gene

Entrez Gene Summary for VAMP2 Gene

  • The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP2 Gene

VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Tetanus and Infant Botulism. Among its related pathways are Neurotransmitter Release Cycle and Metabolism. GO annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620.

UniProtKB/Swiss-Prot for VAMP2 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Gene Wiki entry for VAMP2 Gene

Additional gene information for VAMP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP2 Gene

Genomics for VAMP2 Gene

Regulatory Elements for VAMP2 Gene

Enhancers for VAMP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007833 1.9 FANTOM5 ENCODE dbSUPER 13.2 +323.8 323817 12.5 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC DVL2 PFAS CTC1 WRAP53 POLR2A CNTROB SNORD10 ENSG00000265749 NLGN2 KDM6B
GH17H008185 1.4 ENCODE dbSUPER 17 -24.8 -24838 5.8 MLX ZFP64 YY1 ZNF143 SP3 ZC3H11A NFYC ZFP41 SSRP1 GLIS1 DVL2 PFAS CNTROB WRAP53 ENSG00000265749 POLR2A NEURL4 SENP3 CTC1 LOC100996842
GH17H007233 1.5 ENCODE dbSUPER 13.1 +924.9 924866 11.3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC MEF2D DVL2 CNTROB SNORD10 SNORA48 WRAP53 POLR2A NEURL4 KCTD11 NLGN2 PLSCR3
GH17H008149 1.9 FANTOM5 ENCODE dbSUPER 10.2 +6.2 6228 16 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZNF610 ZNF585B DVL2 ENSG00000265749 CTC1 PER1 PFAS POLR2A CNTROB WRAP53 TP53 SNORD10
GH17H008117 1.4 ENCODE dbSUPER 13.3 +42.3 42279 7.7 FEZF1 YY1 ZNF143 SP3 ZFP41 SSRP1 ZNF610 GLIS1 RCOR2 NBN NEURL4 SENP3 DVL2 NLGN2 PFAS ENSG00000265749 HES7 LOC100996842 ZBTB4 CTC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VAMP2 on UCSC Golden Path with GeneCards custom track

Promoters for VAMP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090964 746 1201 HDGF SIN3A YY1 GLIS2 KLF7 RUNX3 SP3 YY2 ZHX2 REST

Genomic Locations for VAMP2 Gene

Genomic Locations for VAMP2 Gene
chr17:8,159,147-8,163,546
(GRCh38/hg38)
Size:
4,400 bases
Orientation:
Minus strand
chr17:8,062,465-8,066,864
(GRCh37/hg19)

Genomic View for VAMP2 Gene

Genes around VAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP2 Gene

Proteins for VAMP2 Gene

  • Protein details for VAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63027-VAMP2_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 2
    Protein Accession:
    P63027
    Secondary Accessions:
    • P19065
    • Q9BUC2

    Protein attributes for VAMP2 Gene

    Size:
    116 amino acids
    Molecular mass:
    12663 Da
    Quaternary structure:
    • Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB. Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651). Forms a complex with WDFY2 and PRKCZ (PubMed:17313651).

    Three dimensional structures from OCA and Proteopedia for VAMP2 Gene

neXtProt entry for VAMP2 Gene

Post-translational modifications for VAMP2 Gene

  • Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP2 Gene

No data available for DME Specific Peptides for VAMP2 Gene

Domains & Families for VAMP2 Gene

Gene Families for VAMP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for VAMP2 Gene

Suggested Antigen Peptide Sequences for VAMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63027

UniProtKB/Swiss-Prot:

VAMP2_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP2: view

Function for VAMP2 Gene

Molecular function for VAMP2 Gene

GENATLAS Biochemistry:
vesicule associated membrane protein 2,synaptobrevin 2,expressed in neurons forming a synaptic core complex with syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Phenotypes From GWAS Catalog for VAMP2 Gene

Gene Ontology (GO) - Molecular Function for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 9920726
GO:0005516 calmodulin binding ISS --
GO:0005543 phospholipid binding ISS --
genes like me logo Genes that share ontologies with VAMP2: view
genes like me logo Genes that share phenotypes with VAMP2: view

Animal Models for VAMP2 Gene

MGI Knock Outs for VAMP2:

miRNA for VAMP2 Gene

miRTarBase miRNAs that target VAMP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP2 Gene

Localization for VAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP2 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). {ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAMP2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 4
endosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS 1976629
GO:0008021 synaptic vesicle TAS 10099709
genes like me logo Genes that share ontologies with VAMP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP2 Gene

Pathways & Interactions for VAMP2 Gene

genes like me logo Genes that share pathways with VAMP2: view

Gene Ontology (GO) - Biological Process for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly ISS --
GO:0006887 exocytosis TAS 10099709
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA --
GO:0007269 neurotransmitter secretion TAS --
genes like me logo Genes that share ontologies with VAMP2: view

No data available for SIGNOR curated interactions for VAMP2 Gene

Drugs & Compounds for VAMP2 Gene

(11) Drugs for VAMP2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Botulinum Toxin Type B Approved Pharma binder, Target 0

(6) Additional Compounds for VAMP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VAMP2: view

Transcripts for VAMP2 Gene

Unigene Clusters for VAMP2 Gene

Vesicle-associated membrane protein 2 (synaptobrevin 2):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP2 Gene

No ASD Table

Relevant External Links for VAMP2 Gene

GeneLoc Exon Structure for
VAMP2
ECgene alternative splicing isoforms for
VAMP2

Expression for VAMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VAMP2 Gene

Protein differential expression in normal tissues from HIPED for VAMP2 Gene

This gene is overexpressed in Brain (45.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAMP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of VAMP2 Gene:

VAMP2

SOURCE GeneReport for Unigene cluster for VAMP2 Gene:

Hs.25348

mRNA Expression by UniProt/SwissProt for VAMP2 Gene:

P63027-VAMP2_HUMAN
Tissue specificity: Nervous system and skeletal muscle.

Evidence on tissue expression from TISSUES for VAMP2 Gene

  • Nervous system(5)
  • Blood(4.3)
  • Eye(3.3)
  • Adrenal gland(3)
  • Muscle(3)
  • Pancreas(3)
  • Kidney(2.6)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with VAMP2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP2 Gene

Orthologs for VAMP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP2 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia VAMP2 33
  • 96.26 (n)
cow
(Bos Taurus)
Mammalia VAMP2 33 34
  • 94.25 (n)
mouse
(Mus musculus)
Mammalia Vamp2 33 16 34
  • 94.25 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vamp2 33
  • 93.68 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 79 (a)
ManyToMany
VAMP2 33
  • 78.99 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp2 33
  • 83.33 (n)
MGC75977 33
African clawed frog
(Xenopus laevis)
Amphibia vamp2-B-prov 33
zebrafish
(Danio rerio)
Actinopterygii vamp2 33 34
  • 79.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta n-syb 33 34
  • 76.32 (n)
Syb 34
  • 44 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005507 33
  • 72.81 (n)
worm
(Caenorhabditis elegans)
Secernentea snb-1 34
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 34 36
  • 32 (a)
ManyToMany
SNC2 34
  • 30 (a)
ManyToMany
Species where no ortholog for VAMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP2 Gene

ENSEMBL:
Gene Tree for VAMP2 (if available)
TreeFam:
Gene Tree for VAMP2 (if available)

Paralogs for VAMP2 Gene

Paralogs for VAMP2 Gene

(6) SIMAP similar genes for VAMP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VAMP2: view

Variants for VAMP2 Gene

Sequence variations from dbSNP and Humsavar for VAMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000312665 -- 8,164,382(+) CTCCC(C/G)CACCC upstream-variant-2KB
rs1001101161 -- 8,162,659(+) GGAGG(G/T)GCAGG intron-variant, utr-variant-5-prime
rs1001201123 -- 8,163,277(+) ACACC(A/T)AACCC upstream-variant-2KB
rs1002560384 -- 8,162,656(+) CGGGG(A/G)GGGGC intron-variant, utr-variant-5-prime
rs1002614996 -- 8,159,498(+) CTGGG(A/C)TCAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VAMP2 Gene

Variant ID Type Subtype PubMed ID
nsv953826 CNV deletion 24416366
nsv833353 CNV loss 17160897
nsv833352 CNV loss 17160897
nsv574336 CNV loss 21841781
nsv527475 CNV loss 19592680
nsv1964 CNV insertion 18451855

Variation tolerance for VAMP2 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAMP2 Gene

Disorders for VAMP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for VAMP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
infant botulism
  • infant intestinal botulism
primary bacterial infectious disease
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search VAMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAMP2

Genetic Association Database (GAD)
VAMP2
Human Genome Epidemiology (HuGE) Navigator
VAMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP2
genes like me logo Genes that share disorders with VAMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP2 Gene

Publications for VAMP2 Gene

  1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PMID: 1976629) Archer BT … Südhof TC (The Journal of biological chemistry 1990) 2 3 4 22 60
  2. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. (PMID: 18512733) Kawashima K … Iwata N (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 45 60
  3. Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (PMID: 18628682) Abou Jamra R … Schumacher J (Psychiatric genetics 2008) 3 22 45 60
  4. WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. (PMID: 17313651) Fritzius T … Moelling K (The FEBS journal 2007) 3 4 22 60
  5. Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients. (PMID: 17356306) Saito S … Ozaki N (Neuropsychobiology 2006) 3 22 45 60

Products for VAMP2 Gene