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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP1 Gene

protein-coding   GIFtS: 63
GCID: GC12M006571

vesicle-associated membrane protein 1 (synaptobrevin 1)


(Previous symbol: SYB1)
 Explore 6 diseases affiliated with
VAMP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VAMP1    

Aliases
for VAMP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1)1 2     Synaptobrevin-13
SYB11 2 3 5     Vesicle-Associated Membrane Protein 12
VAMP-11 2 3     Synaptobrevin-13
Synaptobrevin 12     

External Ids:    HGNC: 126421   Entrez Gene: 68432   Ensembl: ENSG000001391907   OMIM: 1858805   UniProtKB: P237633   

Export aliases for VAMP1 gene to outside databases

Previous GC identifers: GC12M006426 GC12M006546 GC12M006441 GC12M006425


Summaries
for VAMP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VAMP1:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a
protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a
member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants
that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants
has not been defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Wiki entry for VAMP1


Genomic Views
for VAMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP1 gene promoter:
         AP-1   SREBP-1c   XBP-1   Tal-1beta   SREBP-1b   Max   SREBP-1a   Zic1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VAMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p

VAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006571:  view genomic region     (about GC identifiers)

Start:
 6,571,403 bp from pter      End:
 6,580,153 bp from pter
Size:
 8,751 bases      Orientation:
 minus strand

Proteins
for VAMP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 1  
Size: 118 amino acids; 12902 Da
Subunit: Interacts with VAPA and VAPB
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV
membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity)
Subcellular location: Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein (By similarity).
Cell junction, synapse, synaptosome (By similarity)
Subcellular location: Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein
Secondary accessions: A8MVP3 D3DUR3 O75468 Q15857 Q6FG94 Q8IVC9
Alternative splicing: 3 isoforms:  P23763-1   P23763-3   P23763-2   

Explore the universe of human proteins at neXtProt for VAMP1: NX_P23763

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23763

    • VAMP1 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (3 alternative transcripts): 
    NP_055046.1  NP_058439.1  NP_954740.1  

    ENSEMBL proteins: 
     ENSP00000383702   ENSP00000355122   ENSP00000444181   ENSP00000379602   ENSP00000442696  
    Reactome Protein details: P23763
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: VAMP1
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    Novus Biologicals VAMP1 Proteins
    Novus Biologicals VAMP1 Lysates
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    ProSpec Recombinant Protein for VAMP1
    Uscn Proteins for VAMP1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005887integral to plasma membrane TAS1976629
    GO:0016021integral to membrane ----
    GO:0019717synaptosome ----


    VAMP1 for ontologies           About GeneDecksing



    VAMP1 Antibody Products: 
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    Uscn ELISAs and CLIAs for VAMP1

    Protein Domains /
    Families
    for VAMP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VAMP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016444 Synaptobrevin_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry P23763

    ProtoNet protein and cluster: P23763

    1 Blocks protein family: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Function
    for VAMP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
    Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

         Genatlas biochemistry entry for VAMP1:
    vesicule associated membrane protein 1,synaptobrevin 1,expressed in neurons,forming a synaptic core complex with
    syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N
    ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: VAMP1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: VAMP1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VAMP1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAMP1 

    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9920726


    VAMP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VAMP1:
     Decreased viability of wild-ty 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vamp1):
     behavior/neurological  growth/size  mortality/aging 

    VAMP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VAMP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Botulinum neurotoxicity
    		Botulinum neurotoxicity1.00
    		Proteolytic cleavage of SNARE complex proteins0.89
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    3Disease
    		Disease1.00
    4BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin
    		BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for VAMP1
        Epithelial Tight Junctions

    5        Reactome Pathways for VAMP1
        Proteolytic cleavage of SNARE complex proteins
    BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for VAMP1
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for VAMP1):
        SNARE interactions in vesicular transport


    VAMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP1

    5/8 Interacting proteins for VAMP1 (P237633) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX1AQ166233I2D: score=4 
    VAPAQ9P0L03I2D: score=3 
    VAPBO952923I2D: score=3 
    SNAP23O001613I2D: score=2 
    BCAP31P515723I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0016192vesicle-mediated transport IEA--


    VAMP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VAMP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAMP1

    1 DrugBank Compound for VAMP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type BBotulinum neurotoxin type B precursor (see all 2)93384-44-2targetbinder11752352 17016423 17139284

    1 Novoseek chemical compound relationship for VAMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 3.02 1 16516346 (1)

    Search CenterWatch for drugs/clinical trials and news about VAMP1 

    Transcripts
    for VAMP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VAMP1 gene (3 alternative transcripts): 
    NM_014231.3  NM_016830.2  NM_199245.1  

    Unigene Cluster for VAMP1:

    Vesicle-associated membrane protein 1 (synaptobrevin 1)
    Hs.20021  [show with all ESTs]
    Unigene Representative Sequence: CR749485
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400911 ENST00000361716(uc001qok.3 uc001qoj.3 uc001qol.3)
    ENST00000544432 ENST00000535180 ENST00000396308 ENST00000538970 ENST00000535927
    ENST00000539047

    miRNA
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    hsa-miR-579 hsa-miR-300 hsa-miR-15a hsa-miR-875-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-766 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: VAMP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VAMP1 (see all 7)
    OriGene shRNA RFP: VAMP1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VAMP1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF060538.1 AK289498.1 AK296294.1 AK303137.1 AK309184.1 BC023286.1 CR542214.1 CR542231.1 
    CR749485.1 Z48924.1 

    10 DOTS entries:

    DT.40312062  DT.121214734  DT.97862728  DT.121214702  DT.92438464  DT.95334221  DT.97862736  DT.92438468 
    DT.95143541  DT.95334214 

    24/134 AceView cDNA sequences (see all 134):

    NM_199245 CR542214 AL046810 BU608755 AA764795 BM664607 AA666312 CR542231 
    NM_016830 NM_014231 AI247503 BU624945 AW136851 BC023286 BU626022 AF060538 
    AW629342 BV167306 BI822261 BI757102 AA779535 AA809273 BQ719283 R53068 

    GeneLoc Exon Structure


    Expression
    for VAMP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTCTGAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    Genevestigator expression for VAMP1

    SOURCE GeneReport for Unigene cluster: Hs.20021

    UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
    Tissue specificity: Nervous system, skeletal muscle and adipose tissue

        SABiosciences Expression via Pathway-Focused PCR Array including VAMP1: 
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for VAMP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VAMP1 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vamp11 , 5 vesicle-associated membrane protein 11, 5 93.5(n)1
    98.31(a)1    		   6 (59.32 cM)5
    223171  NM_009496.31  NP_033522.11 
     1252155515 
    chicken
    (Gallus gallus)    		 Aves VAMP11 vesicle-associated membrane protein 1 (synaptobrevin more 79.1(n)
    88.98(a)    		   418273  NM_001039486.1  NP_001034575.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VAMP16
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343381.1(549669-551858)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.197732 Transcribed sequence with moderate similarity to protein more 77.4(n)    CK396978.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta n-syb1 n-synaptobrevin 64.74(n)
    63.46(a)    		   38196  NM_057710.4  NP_477058.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea snb-16
    snb-26
    		 SyNaptoBrevin related family member (snb-2)
    		 62(a)
    44(a)
    		 many → 1
    possible ortholog
    		 V(6655534-6656484)
    V(12344167-12345900)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons VAMP7286
    ATVAMP7216
    (see all 8)    		 vesicle-associated membrane protein 721
    (see all 8)    		 16(a)
    13(a)
    (see all 8)    		 possible ortholog
    possible ortholog
    (see all 8)    		 3(9097514-9098945)
    1(1331466-1333567)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 6)    		 vesicle-associated membrane protein, putative, exp...
    vesicle-associated membrane protein, putative, exp...
    (see all 6)    		 13(a)
    13(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 7(8286841-8290221)
    7(5094639-5098513)


    ENSEMBL Gene Tree for VAMP1 (if available)
    TreeFam Gene Tree for VAMP1 (if available) 

    Paralogs
    for VAMP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP1 gene
    VAMP22  VAMP52  VAMP82  VAMP32  VAMP42  ENSG000002636202  
    5 SIMAP similar genes for VAMP1 using alignment to 3 protein entries:     VAMP1_HUMAN (see all proteins):
    VAMP2    VAMP3    VAMP4    VAMP8    VAMP5

    VAMP1 for paralogs           About GeneDecksing



    Genomic Variants
    for VAMP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/23 NCBI SNPs in VAMP1 are shown (see all 23)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1155266141,2
    		C,F,--6425858(+) ATGCAC/TATGGG 3 -- ut311Minor allele frequency- T:0.04WA 118
    rs1178366791,2
    		C,F,--6425905(+) NNNNGG/ATACAG 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs10455481,2
    		C,F,O,A,H,--6570966(-) TTGATC/TAGGCA 1 -- int133Minor allele frequency- T:0.32NA NS EA WA CSA 2921
    rs1427073631,2
    		--6571018(+) TGGGGA/GAAAGG 1 -- int10--------
    rs1123437071,2
    		C,--6571167(+) TGCCCC/ACGCAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1459961451,2
    		C,--6571169(+) CCCACA/GCAACT 1 -- int10--------
    rs2016071401,2
    		--6571324(+) AAAGCA/GACATG 1 -- ut310--------
    rs715848281,2
    		C,F,--6571347(+) AGAAAC/TGACAC 1 -- ut311Minor allele frequency- T:0.01EU 593
    rs1455318921,2
    		C,--6571409(+) TTAAT-/GGTAGG 1 -- ut310--------
    rs1392356121,2
    		--6571642(+) TCCCAC/GGGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for VAMP1 (6571403 - 6580153 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for VAMP1
         10 CNVs: 3872 8706 2967 9679 75922 8705 86171 75921 30577 37679
    Human Gene Mutation Database (HGMD): VAMP1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for VAMP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VAMP1 for disorders           About GeneDecksing

    OMIM gene information: 185880    OMIM disorders: --

    6 diseases for VAMP1:    About MalaCards
    glomerulopathy    tetanus    parkinson's disease    malaria
    neuronitis    vesiculitis

    1 disease from the University of Copenhagen DISEASES database for VAMP1:
    Tetanus
    Human Genome Epidemiology (HuGE) Navigator: VAMP1 (2 documents)

    Export disorders for VAMP1 gene to outside databases

    Publications
    for VAMP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with VAMP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PubMed id 1976629)1, 2, 3, 9 Archer B.T. III... Suedhof T.C. (1990)
    2. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. (PubMed id 9658161)1, 2, 9 Isenmann S.... Wattenberg B.W. (1998)
    3. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 9 Jagadish M.N....Ward C.W. (1996)
    4. VAMP1 mutation causes dominant hereditary spastic atax ia in Newfoundland families. (PubMed id 22958904)1 Bourassa C.V....Rouleau G.A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Structural and functional analysis of tomosyn identif ies domains important in exocytotic regulation. (PubMed id 21330375)1 Williams A.L....Stuenkel E.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    External Searches for VAMP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VAMP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6843 HGNC: 12642 AceView: VAMP1 Ensembl:ENSG00000139190 euGenes: HUgn6843
    ECgene: VAMP1 Kegg: 6843 H-InvDB: VAMP1

    Other Databases showing VAMP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VAMP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VAMP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VAMP1 gene:
    Search GeneIP for patents involving VAMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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