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Aliases for VAMP1 Gene

Aliases for VAMP1 Gene

  • Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) 2 3
  • SYB1 3 4 6
  • Synaptobrevin-1 3 4
  • VAMP-1 3 4
  • Vesicle-Associated Membrane Protein 1 3
  • Synaptobrevin 1 3
  • SPAX1 3

External Ids for VAMP1 Gene

Previous HGNC Symbols for VAMP1 Gene

  • SYB1

Previous GeneCards Identifiers for VAMP1 Gene

  • GC12M006426
  • GC12M006546
  • GC12M006441
  • GC12M006425
  • GC12M006571

Summaries for VAMP1 Gene

Entrez Gene Summary for VAMP1 Gene

  • Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

GeneCards Summary for VAMP1 Gene

VAMP1 (Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1)) is a Protein Coding gene. Diseases associated with VAMP1 include spastic ataxia 1, autosomal dominant. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP1 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Wiki entry for VAMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP1 Gene

Genomics for VAMP1 Gene

Regulatory Elements for VAMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VAMP1 Gene

Start:
6,462,237 bp from pter
End:
6,470,987 bp from pter
Size:
8,751 bases
Orientation:
Minus strand

Genomic View for VAMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP1 Gene

Proteins for VAMP1 Gene

  • Protein details for VAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23763-VAMP1_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 1
    Protein Accession:
    P23763
    Secondary Accessions:
    • A8MVP3
    • D3DUR3
    • O75468
    • Q15857
    • Q6FG94
    • Q8IVC9

    Protein attributes for VAMP1 Gene

    Size:
    118 amino acids
    Molecular mass:
    12902 Da
    Quaternary structure:
    • Interacts with VAPA and VAPB

    Alternative splice isoforms for VAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAMP1 Gene

Proteomics data for VAMP1 Gene at MOPED

Post-translational modifications for VAMP1 Gene

  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for VAMP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAMP1 (VAMP1)

No data available for DME Specific Peptides for VAMP1 Gene

Domains for VAMP1 Gene

Gene Families for VAMP1 Gene

HGNC:
  • VAMP :Vesicle-associated membrane proteins

Protein Domains for VAMP1 Gene

Suggested Antigen Peptide Sequences for VAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P23763

UniProtKB/Swiss-Prot:

VAMP1_HUMAN :
  • P23763
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP1: view

Function for VAMP1 Gene

Molecular function for VAMP1 Gene

GENATLAS Biochemistry:
vesicule associated membrane protein 1,synaptobrevin 1,expressed in neurons,forming a synaptic core complex with syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Ontology (GO) - Molecular Function for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with VAMP1: view
genes like me logo Genes that share phenotypes with VAMP1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VAMP1 Gene

Localization for VAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP1 Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP1 Gene COMPARTMENTS Subcellular localization image for VAMP1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 3
endosome 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005829 cytosol TAS --
GO:0005887 integral component of plasma membrane TAS 1976629
GO:0008021 synaptic vesicle IBA --
genes like me logo Genes that share ontologies with VAMP1: view

Pathways for VAMP1 Gene

genes like me logo Genes that share pathways with VAMP1: view

Pathways by source for VAMP1 Gene

1 Qiagen pathway for VAMP1 Gene
1 Cell Signaling Technology pathway for VAMP1 Gene
2 Reactome pathways for VAMP1 Gene
1 KEGG pathway for VAMP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0006906 vesicle fusion IBA --
GO:0007268 synaptic transmission --
GO:0007269 neurotransmitter secretion --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with VAMP1: view

Compounds for VAMP1 Gene

(1) Drugbank Compounds for VAMP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Botulinum Toxin Type B
  • Botulinum neurotoxin type B precursor
93384-44-2 target binder

(1) Novoseek inferred chemical compound relationships for VAMP1 Gene

Compound -log(P) Hits PubMed IDs
glucose 3.02 1
genes like me logo Genes that share compounds with VAMP1: view

Transcripts for VAMP1 Gene

Unigene Clusters for VAMP1 Gene

Vesicle-associated membrane protein 1 (synaptobrevin 1):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VAMP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP1 Gene

No ASD Table

Relevant External Links for VAMP1 Gene

GeneLoc Exon Structure for
VAMP1
ECgene alternative splicing isoforms for
VAMP1

Expression for VAMP1 Gene

mRNA expression in normal human tissues for VAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for VAMP1 Gene

This gene is overexpressed in Nasal epithelium (26.6), Frontal cortex (21.8), and Brain (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VAMP1 Gene

SOURCE GeneReport for Unigene cluster for VAMP1 Gene Hs.20021

mRNA Expression by UniProt/SwissProt for VAMP1 Gene

P23763-VAMP1_HUMAN
Tissue specificity: Nervous system, skeletal muscle and adipose tissue
genes like me logo Genes that share expressions with VAMP1: view

Expression partners for VAMP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VAMP1 Gene

Orthologs for VAMP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VAMP1 35
  • 92.37 (n)
  • 92.37 (a)
VAMP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp1 35
  • 93.5 (n)
  • 98.31 (a)
Vamp1 16
Vamp1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP1 35
  • 99.72 (n)
  • 100 (a)
VAMP1 36
  • 47 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAMP1 35
  • 79.1 (n)
  • 88.98 (a)
VAMP1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp1 35
  • 75.19 (n)
  • 78.89 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19773 35
vamp1 35
  • 75.85 (n)
  • 79.59 (a)
vamp1 36
  • 69 (a)
OneToMany
VAMP1 (2 of 2) 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10406 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007721 35
  • 64.13 (n)
  • 67.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syb 35
  • 59.22 (n)
  • 56.31 (a)
n-syb 36
  • 33 (a)
ManyToMany
Syb 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 35
  • 72.37 (n)
  • 80.26 (a)
snb-1 36
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 30 (a)
ManyToMany
SNC2 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14705 35
Species with no ortholog for VAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP1 Gene

ENSEMBL:
Gene Tree for VAMP1 (if available)
TreeFam:
Gene Tree for VAMP1 (if available)

Paralogs for VAMP1 Gene

Paralogs for VAMP1 Gene

Selected SIMAP similar genes for VAMP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VAMP1: view

Variants for VAMP1 Gene

Sequence variations from dbSNP and Humsavar for VAMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12964 -- 6,463,025(+) CTCTG(C/T)TCCCA intron-variant, utr-variant-3-prime
rs13842 -- 6,463,395(-) GCAAG(A/T)GGTTC intron-variant, utr-variant-3-prime
rs1017101 -- 6,465,135(+) TGTCT(G/T)TAGCT intron-variant
rs1034969 -- 6,464,690(+) AATGC(G/T)TTGCA intron-variant, utr-variant-3-prime
rs1045452 -- 6,462,882(-) TTTCC(C/T)TTCGC utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VAMP1 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv818881 CNV Gain 17921354
nsv442252 CNV CNV 18776908
nsv8894 CNV Gain 18304495
nsv525022 CNV Gain 19592680
esv2745471 CNV Deletion 23290073

Relevant External Links for VAMP1 Gene

HapMap Linkage Disequilibrium report
VAMP1
Human Gene Mutation Database (HGMD)
VAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAMP1 Gene

Disorders for VAMP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for VAMP1 Gene in MalaCards »

(1) Diseases for VAMP1 Gene including...

UniProtKB/Swiss-Prot

VAMP1_HUMAN
  • Spastic ataxia 1, autosomal dominant (SPAX1) [MIM:108600]: An autosomal dominant form of spastic ataxia, a progressive neurodegenerative disorder characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance. {ECO:0000269 PubMed:22958904}. Note=The disease is caused by mutations affecting the gene represented in this entry. A mutation affecting a critical donor site for the splicing of VAMP1 isoforms leads to the loss of neuron-specific isoform 1 and subsequently results in haploinsufficiency (PubMed:22958904). Therefore, there would be less neurotransmitter exocytosis in specific regions of the brain, causing the symptoms of SPAX1. {ECO:0000303 PubMed:22958904}.

(1) University of Copenhagen DISEASES for VAMP1 Gene

Relevant External Links for VAMP1

Genetic Association Database (GAD)
VAMP1
Human Genome Epidemiology (HuGE) Navigator
VAMP1
genes like me logo Genes that share disorders with VAMP1: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for VAMP1 Gene

Publications for VAMP1 Gene

  1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PMID: 1976629) Archer B.T. III … Suedhof T.C. (J. Biol. Chem. 1990) 2 3 4 23
  2. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. (PMID: 9658161) Isenmann S. … Wattenberg B.W. (Mol. Biol. Cell 1998) 3 4 23
  3. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish M.N. … Ward C.W. (Biochem. J. 1996) 3 23
  4. Intracellular localization of VAMP-1 protein in human neutrophils. (PMID: 11391393) Nabokina S.M. (Bull. Exp. Biol. Med. 2001) 3 23
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for VAMP1 Gene

Sources for VAMP1 Gene

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