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Aliases & Descriptions for VAMP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp686H12131 2 SYB1 2 , 3 , 5 Synaptobrevin-1 3 VAMP-1 1 , 2 , 3
Descriptions synaptobrevin 1 2 vesicle-associated membrane protein 1 2 vesicle-associated membrane protein 1 (synaptobrevin 1) 2
Search outside databases for aliases for VAMP1 genePrevious GC identifers: GC12M006426 GC12M006546 GC12M006441
Summaries for VAMP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for VAMP1 : Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the maincomponents of a protein complex involved in the docking and/or fusion of synaptic vesicles withthe presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein(VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins withalternative carboxy ends have been described, but the full-length nature of some variants has notbeen defined. [provided by RefSeq] UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 Function : Involved in the targeting and/or fusion of transport vesicles to their target membrane
Gene Wiki entry for VAMP1
Genomic Location for VAMP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the VAMP1 gene Entrez Gene cytogenetic band: 12p Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p VAMP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M006425:
(about GC identifiers )
Start:
6,440,603 bp from pter
End:
6,450,326 bp from pter
Size:
9,724 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_009759.15 Proteins for VAMP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 (See
protein sequence )Recommended Name: Vesicle-associated membrane protein 1 Size : 118 amino acids; 12902 Da
Subunit : Interacts with VAPA and VAPB
Subcellular location : Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane;Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (Bysimilarity)
Subcellular location : Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein(By similarity). Cell junction, synapse, synaptosome (By similarity)
Subcellular location : Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein
Secondary accessions : O75468 Q15857 Q6FG94 Q8IVC9Alternative splicing : 3 isoforms : P23763-1 P23763-3 P23763-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_055046.1 NP_058439.1 NP_954740.1 ENSEMBL proteins: ENSP00000355122 ENSP00000380148 ENSP00000347664 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9
):
About this table Antibodies for VAMP1: Assays for VAMP1:
Protein
Domains/ Families for VAMP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P23763 ProtoNet protein and cluster: P23763
1 Blocks protein family : IPB001388 Synaptobrevin UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 Similarity : Belongs to the synaptobrevin familySimilarity : Contains 1 v-SNARE coiled-coil homology domain
Gene Function for VAMP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016830 Applied Biosystems Silencer ® siRNAs for VAMP1 Sigma-Aldrich siRNA for VAMP1 Sigma-Aldrich shRNA for VAMP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014231                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014231                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_014231  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014231 UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 Function : Involved in the targeting and/or fusion of transport vesicles to their target membrane
Genatlas biochemistry entry for VAMP1 :vesicule associated membrane protein 1,synaptobrevin 1,expressed in neurons,forming a synaptic corecomplex with syntaxin and synaptosome associated proteins,playing a central role in neuralexocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vamp1) :1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for VAMP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for VAMP1 5/20 Interacting proteins for VAMP1 (ENSP00000355122 3 ) via UniProtKB, MINT, and/or STRING (see all 20
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016192 vesicle-mediated transport
IEA --
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Drugs & Compounds for VAMP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for VAMP1 1 Novoseek chemical compound relationship for VAMP1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
glucose
5.66
1
16516346 (1)
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Transcripts for VAMP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016830 Sigma-Aldrich siRNA for VAMP1 Sigma-Aldrich shRNA for VAMP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014231 NM_016830 NM_199245
REFSEQ mRNAs for VAMP1 gene (3 alternative transcripts): NM_014231.3 NM_016830.2 NM_199245.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014231 NM_016830 NM_199245
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014231                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014231                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_014231  
Additional cDNA sequence: AF060538.1 AK289498.1 AK296294.1 AK303137.1 AK309184.1 BC023286.1 CR542214.1 CR542231.1 CR749485.1 Z48924.1
11 DOTS entries : DT.40312062 DT.121214734 DT.97862728 DT.121214702 DT.92438464 DT.95334221 DT.97862736 DT.92438468 DT.95143541 DT.95334214 DT.95334215
24/134 AceView cDNA sequences (see all 134
):NM_014231 NM_016830 BU608755 CR542214 CR542231 AA764795 AA666312 BM664607 NM_199245 AL046810 CA455151 AI023407 AA478494 U25909 AA604792 BQ717992 BQ719283 BE673953 CK429429 AF060538 Z48924 AA809273 AI248737 BI752086
highest scoring ESTs for VAMP1 :AF060538 AU127669 AW504767 BC023286 BE246376 BE246448 BE246453 BG913279 BI752086 BI757102
Unigene Cluster for VAMP1: Vesicle-associated membrane protein 1 (synaptobrevin 1) Hs.20021 [show with all ESTs ] Unigene Representative Sequence: CR749485 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000361716
ENST00000396943
ENST00000355479
Expression for VAMP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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VAMP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for VAMP1 1 / 2 / 3
8 probe-sets matching VAMP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TATTCTGAACSOURCE GeneReport for Unigene cluster: Hs.20021 Expression variation in blood from EXPOLDB for VAMP1
UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 Tissue specificity : Nervous system, skeletal muscle and adipose tissue
Orthologs for VAMP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for VAMP1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for VAMP1 ENSEMBL Gene Tree for VAMP1 Paralogs for VAMP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for VAMP1 gene VAMP2 2 VAMP3 2
SNPs/Variants for VAMP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for VAMP1 (up to first 250kb)
Disorders & Mutations for VAMP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 185880
Medical News for VAMP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for VAMP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/38 PubMed articles for VAMP1 gene (see all 38
): Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PubMed id 1976629) 1, 2, 3, 4 Archer B.T. III... Suedhof T.C. (1990) A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. (PubMed id 9658161) 1, 3, 4 Isenmann S.... Wattenberg B.W. (1998) Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387) 1, 3 Jagadish M.N....Ward C.W. (1996) Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. (PubMed id 18457912) 3 Lu M....Branstrom R. (2008) The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005) 4 Bechtel S....Schupp I. (2007) Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296) 3 Kiel D.P....Karasik D. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004) Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157) 3 Imabayashi H.... Umezawa A. (2003) Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. (PubMed id 12093152) 3 Perez-Branguli F....Blasi J. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing VAMP1
(According to
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and/or
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Other Databases showing VAMP1
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Specialized Databases showing VAMP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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