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Aliases for VAMP1 Gene

Aliases for VAMP1 Gene

  • Vesicle Associated Membrane Protein 1 2 3 5
  • VAMP-1 3 4
  • SYB1 3 4
  • Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) 3
  • Synaptobrevin 1 2
  • Synaptobrevin-1 4
  • SPAX1 3

External Ids for VAMP1 Gene

Previous HGNC Symbols for VAMP1 Gene

  • SYB1

Previous GeneCards Identifiers for VAMP1 Gene

  • GC12M006426
  • GC12M006546
  • GC12M006441
  • GC12M006425
  • GC12M006571

Summaries for VAMP1 Gene

Entrez Gene Summary for VAMP1 Gene

  • Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

GeneCards Summary for VAMP1 Gene

VAMP1 (Vesicle Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with VAMP1 include spastic ataxia 1, autosomal dominant and spastic ataxia 1. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Neuroscience. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VAMP3.

UniProtKB/Swiss-Prot for VAMP1 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Gene Wiki entry for VAMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP1 Gene

Genomics for VAMP1 Gene

Regulatory Elements for VAMP1 Gene

Enhancers for VAMP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VAMP1 on UCSC Golden Path with GeneCards custom track

Promoters for VAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAMP1 Gene

Chromosome:
12
Start:
6,462,237 bp from pter
End:
6,470,987 bp from pter
Size:
8,751 bases
Orientation:
Minus strand

Genomic View for VAMP1 Gene

Genes around VAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP1 Gene

Proteins for VAMP1 Gene

  • Protein details for VAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23763-VAMP1_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 1
    Protein Accession:
    P23763
    Secondary Accessions:
    • A8MVP3
    • D3DUR3
    • O75468
    • Q15857
    • Q6FG94
    • Q8IVC9

    Protein attributes for VAMP1 Gene

    Size:
    118 amino acids
    Molecular mass:
    12902 Da
    Quaternary structure:
    • Interacts with VAPA and VAPB.

    Alternative splice isoforms for VAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAMP1 Gene

Proteomics data for VAMP1 Gene at MOPED

Post-translational modifications for VAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAMP1 (VAMP1)

No data available for DME Specific Peptides for VAMP1 Gene

Domains & Families for VAMP1 Gene

Gene Families for VAMP1 Gene

Protein Domains for VAMP1 Gene

Suggested Antigen Peptide Sequences for VAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P23763

UniProtKB/Swiss-Prot:

VAMP1_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP1: view

Function for VAMP1 Gene

Molecular function for VAMP1 Gene

GENATLAS Biochemistry:
vesicule associated membrane protein 1,synaptobrevin 1,expressed in neurons,forming a synaptic core complex with syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Gene Ontology (GO) - Molecular Function for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with VAMP1: view
genes like me logo Genes that share phenotypes with VAMP1: view

Human Phenotype Ontology for VAMP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VAMP1 Gene

Localization for VAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP1 Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP1 Gene COMPARTMENTS Subcellular localization image for VAMP1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
plasma membrane 5
endosome 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane TAS --
GO:0031201 SNARE complex IBA --
GO:0035577 NOT azurophil granule membrane IDA 11391393
genes like me logo Genes that share ontologies with VAMP1: view

Pathways & Interactions for VAMP1 Gene

genes like me logo Genes that share pathways with VAMP1: view

Pathways by source for VAMP1 Gene

1 KEGG pathway for VAMP1 Gene
1 Qiagen pathway for VAMP1 Gene

Gene Ontology (GO) - Biological Process for VAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035493 SNARE complex assembly IEA --
genes like me logo Genes that share ontologies with VAMP1: view

No data available for SIGNOR curated interactions for VAMP1 Gene

Drugs & Compounds for VAMP1 Gene

(1) Drugs for VAMP1 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Botulinum Toxin Type B Approved Pharma binder, Target 0

(1) Additional Compounds for VAMP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VAMP1: view

Transcripts for VAMP1 Gene

Unigene Clusters for VAMP1 Gene

Vesicle-associated membrane protein 1 (synaptobrevin 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP1 Gene

No ASD Table

Relevant External Links for VAMP1 Gene

GeneLoc Exon Structure for
VAMP1
ECgene alternative splicing isoforms for
VAMP1

Expression for VAMP1 Gene

mRNA expression in normal human tissues for VAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VAMP1 Gene

This gene is overexpressed in Nasal epithelium (26.6), Frontal cortex (21.8), and Brain (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VAMP1 Gene



SOURCE GeneReport for Unigene cluster for VAMP1 Gene Hs.20021

mRNA Expression by UniProt/SwissProt for VAMP1 Gene

P23763-VAMP1_HUMAN
Tissue specificity: Nervous system, skeletal muscle and adipose tissue.
genes like me logo Genes that share expression patterns with VAMP1: view

Protein tissue co-expression partners for VAMP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VAMP1 Gene

Orthologs for VAMP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VAMP1 35
  • 92.37 (n)
  • 92.37 (a)
VAMP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp1 35
  • 93.5 (n)
  • 98.31 (a)
Vamp1 16
Vamp1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP1 35
  • 99.72 (n)
  • 100 (a)
VAMP1 36
  • 47 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAMP1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves VAMP1 35
  • 79.1 (n)
  • 88.98 (a)
VAMP1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp1 35
  • 75.19 (n)
  • 78.89 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19773 35
vamp1 35
  • 75.85 (n)
  • 79.59 (a)
vamp1 36
  • 69 (a)
OneToMany
VAMP1 (2 of 2) 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10406 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007721 35
  • 64.13 (n)
  • 67.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syb 35
  • 59.22 (n)
  • 56.31 (a)
n-syb 36
  • 33 (a)
ManyToMany
Syb 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 35
  • 72.37 (n)
  • 80.26 (a)
snb-1 36
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 30 (a)
ManyToMany
SNC2 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14705 35
Species with no ortholog for VAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP1 Gene

ENSEMBL:
Gene Tree for VAMP1 (if available)
TreeFam:
Gene Tree for VAMP1 (if available)

Paralogs for VAMP1 Gene

Paralogs for VAMP1 Gene

(5) SIMAP similar genes for VAMP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VAMP1: view

Variants for VAMP1 Gene

Sequence variations from dbSNP and Humsavar for VAMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2058288 -- 6,469,706(+) TGTAT(C/T)AGACA intron-variant
rs2072376 -- 6,470,646(+) CCGAC(C/T)ACCCC nc-transcript-variant, utr-variant-5-prime
rs2072377 -- 6,471,062(+) CGCGC(A/T)TTCAG upstream-variant-2KB
rs2072378 -- 6,471,083(+) CGGCT(C/T)CCTGG upstream-variant-2KB
rs12964 -- 6,463,025(+) CTCTG(C/T)TCCCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VAMP1 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv818881 CNV Gain 17921354
nsv442252 CNV CNV 18776908
nsv8894 CNV Gain 18304495
nsv525022 CNV Gain 19592680
esv2745471 CNV Deletion 23290073

Variation tolerance for VAMP1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP1 Gene

HapMap Linkage Disequilibrium report
VAMP1
Human Gene Mutation Database (HGMD)
VAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAMP1 Gene

Disorders for VAMP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for VAMP1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spastic ataxia 1, autosomal dominant
  • autosomal dominant spastic ataxia type 1
spastic ataxia 1
  • spastic ataxia 1, autosomal dominant
spastic ataxia
botulism
  • foodborne botulism
- elite association - COSMIC cancer census association via MalaCards
Search VAMP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VAMP1_HUMAN
  • Spastic ataxia 1, autosomal dominant (SPAX1) [MIM:108600]: An autosomal dominant form of spastic ataxia, a progressive neurodegenerative disorder characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance. {ECO:0000269 PubMed:22958904}. Note=The disease is caused by mutations affecting the gene represented in this entry. A mutation affecting a critical donor site for the splicing of VAMP1 isoforms leads to the loss of neuron-specific isoform 1 and subsequently results in haploinsufficiency (PubMed:22958904). Therefore, there would be less neurotransmitter exocytosis in specific regions of the brain, causing the symptoms of SPAX1. {ECO:0000303 PubMed:22958904}.

Relevant External Links for VAMP1

Genetic Association Database (GAD)
VAMP1
Human Genome Epidemiology (HuGE) Navigator
VAMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP1
genes like me logo Genes that share disorders with VAMP1: view

No data available for Genatlas for VAMP1 Gene

Publications for VAMP1 Gene

  1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PMID: 1976629) Archer B.T. III … Suedhof T.C. (J. Biol. Chem. 1990) 2 3 4 23 67
  2. Intracellular localization of VAMP-1 protein in human neutrophils. (PMID: 11391393) Nabokina S.M. (Bull. Exp. Biol. Med. 2001) 3 23
  3. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. (PMID: 9658161) Isenmann S. … Wattenberg B.W. (Mol. Biol. Cell 1998) 3 23
  4. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish M.N. … Ward C.W. (Biochem. J. 1996) 3 23
  5. Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility. (PMID: 25881291) Sevlever D. … Belbin O. (Mol Neurodegener 2015) 3

Products for VAMP1 Gene

Sources for VAMP1 Gene

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