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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VAMP1 Gene

protein-coding   GIFtS: 63
GCID: GC12M006571

Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1)


(Previous symbol: SYB1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1)1 2     synaptobrevin-12
SYB11 2 3 5     Vesicle-Associated Membrane Protein 12
VAMP-12 3     Synaptobrevin-13
Synaptobrevin 12     

External Ids:    HGNC: 126421   Entrez Gene: 68432   Ensembl: ENSG000001391907   OMIM: 1858805   UniProtKB: P237633   

Export aliases for VAMP1 gene to outside databases

Previous GC identifers: GC12M006426 GC12M006546 GC12M006441 GC12M006425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAMP1 Gene:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a
protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1
is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice
variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of
some variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for VAMP1 Gene: 
VAMP1 (vesicle-associated membrane protein 1 (synaptobrevin 1)) is a protein-coding gene. Diseases associated with VAMP1 include autosomal dominant spastic ataxia 1, and vesiculitis, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Proteolytic cleavage of SNARE complex proteins. GO annotations related to this gene include protein binding. An important paralog of this gene is VAMP2.

UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

Gene Wiki entry for VAMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAMP1 gene promoter:
         AP-1   SREBP-1c   XBP-1   Tal-1beta   SREBP-1b   Max   SREBP-1a   Zic1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VAMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VAMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p

VAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAMP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006571:  view genomic region     (about GC identifiers)

Start:
6,571,403 bp from pter      End:
6,580,153 bp from pter
Size:
8,751 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763 (See protein sequence)
Recommended Name: Vesicle-associated membrane protein 1  
Size: 118 amino acids; 12902 Da
Subunit: Interacts with VAPA and VAPB
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass
type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity)
Subcellular location: Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein (By
similarity). Cell junction, synapse, synaptosome (By similarity)
Subcellular location: Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein
Secondary accessions: A8MVP3 D3DUR3 O75468 Q15857 Q6FG94 Q8IVC9
Alternative splicing: 3 isoforms:  P23763-1   P23763-3   P23763-2   

Explore the universe of human proteins at neXtProt for VAMP1: NX_P23763

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23763

  • VAMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_055046.1  NP_058439.1  NP_954740.1  

    ENSEMBL proteins: 
     ENSP00000383702   ENSP00000355122   ENSP00000444181   ENSP00000379602  
    Reactome Protein details: P23763
    Human Recombinant Protein Products for VAMP1: 
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    ProSpec Recombinant Protein for VAMP1
    Cloud-Clone Corp. Proteins for VAMP1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005887integral to plasma membrane TAS1976629
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--

    VAMP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VAMP: Vesicle-associated membrane proteins

    2 InterPro protein domains:
     IPR016444 Synaptobrevin_met/fun
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry P23763

    ProtoNet protein and cluster: P23763

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    VAMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAMP1_HUMAN, P23763
    Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane

         Genatlas biochemistry entry for VAMP1:
    vesicule associated membrane protein 1,synaptobrevin 1,expressed in neurons,forming a synaptic core complex with
    syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N
    ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9920726
         
    VAMP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VAMP1:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vamp1):
     behavior/neurological  growth/size  mortality/aging 

    VAMP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VAMP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAMP1 
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    SwitchGear 3'UTR luciferase reporter plasmidVAMP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VAMP1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Botulinum neurotoxicity
    Botulinum neurotoxicity0.89
    Proteolytic cleavage of SNARE complex proteins0.89
    3Transmission across Chemical Synapses
    Neuronal System0.67
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for VAMP1
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for VAMP1
        Neuroscience


    5        Reactome Pathways for VAMP1
        Proteolytic cleavage of SNARE complex proteins
    BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for VAMP1
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for VAMP1):
        SNARE interactions in vesicular transport


    VAMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAMP1

    5/8 Interacting proteins for VAMP1 (P237633) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX1AQ166233I2D: score=4 
    VAPAQ9P0L03I2D: score=3 
    VAPBO952923I2D: score=3 
    SNAP23O001613I2D: score=2 
    BCAP31P515723I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0016192vesicle-mediated transport IEA--

    VAMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VAMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for VAMP1

    1 DrugBank Compound for VAMP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type BBotulinum neurotoxin type B precursor (see all 2)93384-44-2targetbinder11752352 17016423 17139284

    1 Novoseek inferred chemical compound relationship for VAMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 3.02 1 16516346 (1)

    Search CenterWatch for drugs/clinical trials and news about VAMP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VAMP1 gene (3 alternative transcripts): 
    NM_014231.3  NM_016830.2  NM_199245.1  

    Unigene Cluster for VAMP1:

    Vesicle-associated membrane protein 1 (synaptobrevin 1)
    Hs.20021  [show with all ESTs]
    Unigene Representative Sequence: CR749485
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400911 ENST00000361716(uc001qok.3 uc001qoj.3 uc001qol.3)
    ENST00000544432 ENST00000535180 ENST00000396308 ENST00000538970 ENST00000535927
    ENST00000539047

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    Additional mRNA sequence: 

    AF060538.1 AK289498.1 AK296294.1 AK303137.1 AK309184.1 BC023286.1 CR542214.1 CR542231.1 
    CR749485.1 Z48924.1 

    10 DOTS entries:

    DT.40312062  DT.121214734  DT.97862728  DT.121214702  DT.92438464  DT.95334221  DT.97862736  DT.92438468 
    DT.95143541  DT.95334214 

    24/134 AceView cDNA sequences (see all 134):

    BM664607 AL046810 NM_014231 AA666312 NM_199245 NM_016830 CR542214 BU608755 
    AA764795 CR542231 AU279974 R53068 BI757102 AW504767 Z48924 AL041270 
    CR749485 BQ771980 BC023286 BM972448 AA830549 AA779535 BM709411 BQ718331 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VAMP1 expression in normal human tissues (normalized intensities)      VAMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCTGAAC
    VAMP1 Expression
    About this image


    VAMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Thalamus
             Ciliary Ganglion   
     
     Spinal Cord (Nervous System)
             Dorsal Root Ganglion   
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Thymus (Hematopoietic System)
     
     Blood (Hematopoietic System)

    Genevestigator expression for VAMP1

    SOURCE GeneReport for Unigene cluster: Hs.20021

    UniProtKB/Swiss-Prot: VAMP1_HUMAN, P23763
    Tissue specificity: Nervous system, skeletal muscle and adipose tissue

        SABiosciences Expression via Pathway-Focused PCR Array including VAMP1: 
              Parkinson's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VAMP1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vamp11 , 5 vesicle-associated membrane protein 11, 5 93.5(n)1
    98.31(a)1
      6 (59.32 cM)5
    223171  NM_009496.31  NP_033522.11 
     1252155515 
    chicken
    (Gallus gallus)
    Aves VAMP11 vesicle-associated membrane protein 1 (synaptobrevin more 79.1(n)
    88.98(a)
      418273  NM_001039486.1  NP_001034575.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAMP16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343381.1(508924-551858)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197732 Transcribed sequence with moderate similarity to protein more 77.4(n)    CK396978.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta n-syb1 n-synaptobrevin 64.74(n)
    63.46(a)
      38196  NM_057710.4  NP_477058.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snb-16
    snb-26
    Protein SNB-2
    61(a)
    38(a)
    many ↔ many
    many ↔ many
    V(6655551-6656501)
    V(12344186-12345919)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNC16
    SNC26
    Vesicle membrane receptor protein (v-SNARE) involv...
    Vesicle membrane receptor protein (v-SNARE) involv...
    26(a)
    24(a)
    many ↔ many
    many ↔ many
    I(87286-87752)
    XV(930734-931081)


    ENSEMBL Gene Tree for VAMP1 (if available)
    TreeFam Gene Tree for VAMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VAMP1 gene
    VAMP22  VAMP82  VAMP32  VAMP42  ENSG000002636202  
    5 SIMAP similar genes for VAMP1 using alignment to 2 protein entries:     VAMP1_HUMAN (see all proteins):
    VAMP2    VAMP3    VAMP4    VAMP8    VAMP5

    VAMP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 SNPs in VAMP1 are shown (see all 249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10455481,2
    C,F,O,A,H--6502222(-) TTGATC/TAGGCA 3 -- ds500133Minor allele frequency- T:0.32NA NS EA WA CSA 2921
    rs1427073631,2
    C--6502274(+) TGGGGA/GAAAGG 3 -- ds50010--------
    rs1123437071,2
    C--6502423(+) TGCCCC/ACGCAA 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1459961451,2
    C--6502425(+) CCCACA/GCAACT 3 -- ds50010--------
    rs1399381311,2
    C--6502506(+) CTTCCC/TGTGCT 3 -- ds50010--------
    rs1418381881,2
    C,F--6502543(+) AGACCG/ACACAG 3 -- ds50011Minor allele frequency- A:0.00NA 4552
    rs715848261,2
    C,F--6502550(+) ACAGCG/ACGTGT 3 -- ds50012Minor allele frequency- A:0.00NA EU 5855
    rs2016071401,2
    --6502580(+) AAAGCA/GACATG 3 -- ds50010--------
    rs715848281,2
    C,F--6502603(+) AGAAAC/TGACAC 3 -- ds50011Minor allele frequency- T:0.01EU 593
    rs1455318921,2
    C--6502665(+) TTAAT-/GGTAGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for VAMP1 (6571403 - 6580153 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for VAMP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745471CNV Deletion23290073
    nsv525022CNV Gain19592680
    nsv8894CNV Gain18304495
    esv34390CNV Gain17911159
    esv34325CNV Gain17911159
    nsv818881CNV Gain17921354
    essv12131CNV CNV17122850
    nsv442252CNV CNV18776908
    dgv453e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): VAMP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VAMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for VAMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 185880    OMIM disorders: --

    8 diseases for VAMP1:    About MalaCards
    autosomal dominant spastic ataxia 1    vesiculitis    tetanus    spasticity
    parkinson's disease    endotheliitis    gastric cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for VAMP1:
    Tetanus

    VAMP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): VAMP1
    Human Genome Epidemiology (HuGE) Navigator: VAMP1 (2 documents)

    Export disorders for VAMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VAMP1 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with VAMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (PubMed id 1976629)1, 2, 3, 9 Archer B.T. III... Suedhof T.C. (1990)
    2. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. (PubMed id 9658161)1, 2, 9 Isenmann S.... Wattenberg B.W. (1998)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)1, 4 Kiel D.P....Karasik D. (2007)
    5. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 9 Jagadish M.N....Ward C.W. (1996)
    6. VAMP1 mutation causes dominant hereditary spastic atax ia in Newfoundland families. (PubMed id 22958904)1 Bourassa C.V....Rouleau G.A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6843 HGNC: 12642 AceView: VAMP1 Ensembl:ENSG00000139190 euGenes: HUgn6843
    ECgene: VAMP1 Kegg: 6843 H-InvDB: VAMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VAMP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VAMP1 gene:
    Search GeneIP for patents involving VAMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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