Aliases for VAC14 Gene
Aliases for VAC14 Gene
External Ids for VAC14 Gene
- HGNC: 25507
- Entrez Gene: 55697
- Ensembl: ENSG00000103043
- OMIM: 604632
- UniProtKB: Q08AM6
Previous HGNC Symbols for VAC14 Gene
- TAX1BP2
Previous GeneCards Identifiers for VAC14 Gene
- GC16M069280
- GC16M070721
- GC16M056552
Summaries for VAC14 Gene
-
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
GeneCards Summary for VAC14 Gene
VAC14 (Vac14, PIKFYVE Complex Component) is a Protein Coding gene. Diseases associated with VAC14 include Striatonigral Degeneration, Childhood-Onset and Striatonigral Degeneration. Among its related pathways are HTLV-I infection and Metabolism. GO annotations related to this gene include binding and receptor activity.
UniProtKB/Swiss-Prot for VAC14 Gene
-
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAC14 Gene
Genomics for VAC14 Gene
Regulatory Elements for VAC14 Gene
Enhancers for VAC14 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around VAC14 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for VAC14 Gene
- Chromosome:
- 16
- Start:
- 70,687,439 bp from pter
- End:
- 70,801,166 bp from pter
- Size:
- 113,728 bases
- Orientation:
- Minus strand
Genomic View for VAC14 Gene
Genes around VAC14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.2 by Ensembl
- 16q22.1-q22.2 by Entrez Gene
- 16q22.1-q22.2 by HGNC
VAC14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VAC14 Gene
Proteins for VAC14 Gene
-
Protein details for VAC14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08AM6-VAC14_HUMAN
- Recommended name:
- Protein VAC14 homolog
- Protein Accession:
- Q08AM6
- B3KPJ5
- B3KSM8
- Q13174
- Q6IA12
- Q7L4Y1
- Q9BW96
- Q9H6V6
Protein attributes for VAC14 Gene
- Size:
- 782 amino acids
- Molecular mass:
- 87973 Da
- Quaternary structure:
-
- Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with NOS1. Interacts with HTLV-1 Tax.
- SequenceCaution:
-
- Sequence=AAB03813.1; Type=Miscellaneous discrepancy; Note=Unknown C-terminal region.; Evidence={ECO:0000305}; Sequence=BAB15145.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for VAC14 Gene
Post-translational modifications for VAC14 Gene
Other Protein References for VAC14 Gene
Antibody Products
- Novus Biologicals Antibodies for VAC14
- Invitrogen Antibodies for VAC14
- antibodies-online Antibodies for VAC14: See all 12
- Search GeneTex for Antibodies for VAC14
-
Santa Cruz Biotechnology (SCBT) Antibodies for VAC14
Protein Products
-
OriGene Purified Proteins for VAC14
- Search Origene for MassSpec and Protein Over-expression Lysates for VAC14
- Origene Custom Protein Services for VAC14
- antibodies-online Proteins for VAC14: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for VAC14
Assay Products
No data available for DME Specific Peptides for VAC14 Gene
Domains & Families for VAC14 Gene
Protein Domains for VAC14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VAC14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q08AM6UniProtKB/Swiss-Prot:
VAC14_HUMAN :- The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.
- Belongs to the VAC14 family.
- Contains 6 HEAT repeats.
- Domain:
-
- The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.
- Family:
-
- Belongs to the VAC14 family.
- Similarity:
-
- Contains 6 HEAT repeats.
No data available for Gene Families for VAC14 Gene
Function for VAC14 Gene
Molecular function for VAC14 Gene
- UniProtKB/Swiss-Prot Function:
- The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004872 | receptor activity | NAS | 8611628 |
| GO:0005515 | protein binding | IPI | 17161399 |
Phenotypes for VAC14 Gene
- MGI mutant phenotypes for VAC14:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for VAC14:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VAC14
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VAC14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VAC14 gene
- Search ViGene Biosciences for VAC14
CRISPR Products
-
OriGene CRISPR knockouts for VAC14
- GenScript: Design CRISPR guide RNA sequences for VAC14
miRNA for VAC14 Gene
- miRTarBase miRNAs that target VAC14
-
- hsa-mir-429 (MIRT016639)
- hsa-mir-200a-3p (MIRT020349)
- hsa-mir-200c-3p (MIRT021072)
- hsa-mir-141-3p (MIRT021651)
- hsa-mir-200b-3p (MIRT024128)
- hsa-mir-589-5p (MIRT037789)
- hsa-mir-423-5p (MIRT038068)
- hsa-mir-30c-2-3p (MIRT038701)
- hsa-mir-377-3p (MIRT439317)
- hsa-mir-3941 (MIRT542377)
- hsa-mir-381-3p (MIRT542378)
- hsa-mir-6768-5p (MIRT542379)
- hsa-mir-300 (MIRT542380)
- hsa-mir-603 (MIRT542381)
- hsa-mir-362-3p (MIRT542382)
- hsa-mir-8485 (MIRT542383)
- hsa-mir-329-3p (MIRT542384)
- hsa-mir-6882-5p (MIRT542385)
- hsa-mir-124-5p (MIRT611997)
- hsa-mir-5689 (MIRT675653)
miRNA Products
- Search ViGene Biosciences for VAC14
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VAC14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VAC14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for VAC14
-
ViGene Biosciences adenoviral particle packaged cDNA for VAC14 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VAC14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VAC14 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VAC14 Gene
Localization for VAC14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VAC14 Gene
- Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| golgi apparatus | 4 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0010008 | endosome membrane | IEA,IDA | 17556371 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for VAC14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI Metabolism |
.63
|
|
| 2 | Metabolism |
.37
|
|
| 3 | HTLV-I infection | ||
| 4 | Viral carcinogenesis | ||
| 5 | Glycerophospholipid biosynthesis | ||
Pathways by source for VAC14 Gene
7 Reactome pathways for VAC14 Gene
2 KEGG pathways for VAC14 Gene
Interacting Proteins for VAC14 Gene
Selected Interacting proteins:
Q08AM6-VAC14_HUMAN
ENSP00000261776
for VAC14 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0007165 | signal transduction | NAS | 8611628 |
| GO:0016032 | viral process | IEA | -- |
| GO:0043550 | regulation of lipid kinase activity | IEA | -- |
No data available for SIGNOR curated interactions for VAC14 Gene
Drugs & Compounds for VAC14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Docetaxel | Approved May 1996, Investigational | Pharma | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer | 1918 |
Transcripts for VAC14 Gene
mRNA/cDNA for VAC14 Gene
- (8) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (258) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VAC14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VAC14
- GenScript: Design CRISPR guide RNA sequences for VAC14
miRNA Products
- Search ViGene Biosciences for VAC14
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VAC14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VAC14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: |
Expression for VAC14 Gene
This gene is overexpressed in Bone (32.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VAC14 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of VAC14 Gene:
VAC14SOURCE GeneReport for Unigene cluster for VAC14 Gene:
Hs.445061mRNA Expression by UniProt/SwissProt for VAC14 Gene:
Q08AM6-VAC14_HUMAN
Tissue specificity:
Ubiquitously expressed.
Primer Products
-
OriGene qPCR primer pairs for VAC14
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VAC14 Gene
Orthologs for VAC14 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VAC14 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | VAC14 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | VAC14 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Vac14 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vac14 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | VAC14 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | VAC14 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VAC14 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VAC14 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vac14 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vac14 34 35 |
|
||
| wufb68e05 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000770 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5608 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | K04G2.6 34 |
|
||
| vacl-14 35 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER049W 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VAC14 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E05193g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G01690 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0223700 34 |
|
||
| Os.11686 34 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02409 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10719 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC25H2.03 34 |
|
- Species where no ortholog for VAC14 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VAC14 Gene
(1) SIMAP similar genes for VAC14 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for VAC14 Gene
No data available for Paralogs for VAC14 Gene
Variants for VAC14 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs762388639 | Striatonigral degeneration, childhood-onset (SNDC) [MIM:617054], Pathogenic | 70,762,915(+) | AGAGC(A/C)ACTTG | intron-variant, reference, missense | |
| VAR_077032 | Striatonigral degeneration, childhood-onset (SNDC) [MIM:617054] | ||||
| VAR_077033 | Striatonigral degeneration, childhood-onset (SNDC) [MIM:617054] | ||||
| rs749094914 | Pathogenic | 70,698,729(+) | CGAGG(C/T)GAACT | reference, missense | |
| rs879255555 | Pathogenic | 70,744,422(-) | CTCTG(A/G)TAAGT | splice-donor-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv7285 | OTHER | inversion | 18451855 |
| nsv572948 | CNV | loss | 21841781 |
| nsv572947 | CNV | loss | 21841781 |
| nsv572946 | CNV | loss | 21841781 |
| nsv572945 | CNV | gain | 21841781 |
| nsv517391 | CNV | loss | 19592680 |
| nsv475686 | CNV | novel sequence insertion | 20440878 |
| nsv471094 | CNV | loss | 18288195 |
| nsv1059226 | CNV | gain | 25217958 |
| esv3892881 | CNV | gain | 25118596 |
| esv2758653 | CNV | gain | 17122850 |
Residual Variation Intolerance Score:
6.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.21;
39.93% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for VAC14 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAC14 Gene
Disorders for VAC14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| striatonigral degeneration, childhood-onset |
|
|
| striatonigral degeneration |
|
|
| congenital hydrocephalus |
|
|
Search VAC14 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for VAC14
No data available for UniProtKB/Swiss-Prot and Genatlas for VAC14 Gene
Publications for VAC14 Gene
- A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. (PMID: 15542851) Sbrissa D. … Shisheva A. (Mol. Cell. Biol. 2004) 2 3 4 22 64
- Core protein machinery for mammalian phosphatidylinositol 3,5- bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. (PMID: 17556371) Sbrissa D. … Shisheva A. (J. Biol. Chem. 2007) 3 4 22 64
- Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif. (PMID: 17161399) Lemaire J.F. … McPherson P.S. (FEBS Lett. 2006) 3 4 22 64
- Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein. (PMID: 8611628) Mireskandari A. … Brady J.N. (Biochim. Biophys. Acta 1996) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
Products for VAC14 Gene
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- GenScript: Design CRISPR guide RNA sequences for VAC14
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- Novus Biologicals Antibodies for VAC14
- Novus Biologicals proteins and lysates for VAC14
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for VAC14: See all 12
- Search antibodies-online for kits
- antibodies-online Proteins for VAC14: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for VAC14
- Search GeneTex for Proteins for VAC14
- ViGene Biosciences adenoviral particle packaged cDNA for VAC14 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VAC14 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VAC14 gene
- Search ViGene Biosciences for VAC14
- Santa Cruz Biotechnology (SCBT) Antibodies for VAC14
- Search Santa Cruz Biotechnology (SCBT) for VAC14 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for VAC14 CRISPR
- Horizon Cell Lines for VAC14
- Cyagen custom Knockout/knockin (KOKI) mouse models for VAC14
- VectorBuilder custom plasmid, inducible vectors for VAC14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VAC14
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for VAC14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
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