Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VAC14 Gene

protein-coding   GIFtS: 59
GCID: GC16M070721

Vac14 Homolog (S. Cerevisiae)

(Previous name: Tax1 (human T-cell leukemia virus type I) binding protein...)
(Previous symbol: TAX1BP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Vac14 Homolog (S. Cerevisiae)1 2     Tax1-Binding Protein 22 3
TAX1BP21 2 3 5     ArPIKfyve2
TRX2 3 5     Protein VAC14 Homolog2
Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 21 2     Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 12

External Ids:    HGNC: 255071   Entrez Gene: 556972   Ensembl: ENSG000001030437   OMIM: 6046325   UniProtKB: Q08AM63   

Export aliases for VAC14 gene to outside databases

Previous GC identifers: GC16M069280 GC16M056552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for VAC14 Gene:
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically
with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of
a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are
the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390).
VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 (PubMed 17556371)).(supplied by OMIM, Feb 2010)

GeneCards Summary for VAC14 Gene:
VAC14 (Vac14 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VAC14 include communicating hydrocephalus, and t-cell leukemia. GO annotations related to this gene include receptor activity and kinase activator activity.

UniProtKB/Swiss-Prot: VAC14_HUMAN, Q08AM6
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol
3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to
maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate
(PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB)
transport intermediates from early endosomes

Gene Wiki entry for VAC14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VAC14 gene promoter:
         NF-1   Pbx1a   GCNF   Nkx2-5   CREB   GCNF-1   deltaCREB   ARP-1   GCNF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVAC14 promoter sequence
   Search Chromatin IP Primers for VAC14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAC14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.1

VAC14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAC14 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M070721:  view genomic region     (about GC identifiers)

Start:
70,721,342 bp from pter      End:
70,835,064 bp from pter
Size:
113,723 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: VAC14_HUMAN, Q08AM6 (See protein sequence)
Recommended Name: Protein VAC14 homolog  
Size: 782 amino acids; 87973 Da
Subunit: Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of
PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with
NOS1. Interacts with HTLV-1 Tax
Sequence caution: Sequence=AAB03813.1; Type=Miscellaneous discrepancy; Note=Unknown C-terminal region;
Sequence=BAB15145.1; Type=Erroneous initiation;
Secondary accessions: B3KPJ5 Q13174 Q6IA12 Q7L4Y1 Q9BW96 Q9H6V6

Explore the universe of human proteins at neXtProt for VAC14: NX_Q08AM6

Explore proteomics data for VAC14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VAC14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060522.3  
    ENSEMBL proteins: 
     ENSP00000463485   ENSP00000457809   ENSP00000261776   ENSP00000454650   ENSP00000439284  
     ENSP00000455731  
    Reactome Protein details: Q08AM6

    VAC14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VAC14
    OriGene Protein Over-expression Lysate for VAC14
    OriGene Custom MassSpec
    OriGene Custom Protein Services for VAC14
    GenScript Custom Purified and Recombinant Proteins Services for VAC14
    Novus Biologicals VAC14 Proteins
    Novus Biologicals VAC14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VAC14

    VAC14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VAC14
    Novus Biologicals VAC14 Antibodies
    Abcam antibodies for VAC14
    Cloud-Clone Corp. Antibodies for VAC14
    Search ThermoFisher Antibodies for VAC14
    LSBio Antibodies in human, mouse, rat for VAC14

    VAC14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VAC14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAC14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VAC14
    Cloud-Clone Corp. CLIAs for VAC14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021841 VAC14_Fig4p-bd
     IPR026825 Vac14
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q08AM6

    ProtoNet protein and cluster: Q08AM6

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: VAC14_HUMAN, Q08AM6
    Domain: The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the
    formation and maintenance of the PI(3,5)P2 regulatory complex
    Similarity: Belongs to the VAC14 family
    Similarity: Contains 6 HEAT repeats


    VAC14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VAC14_HUMAN, Q08AM6
    Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol
    3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to
    maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate
    (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB)
    transport intermediates from early endosomes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS8611628
    GO:0005488binding ----
    GO:0005515protein binding IPI17161399
    GO:0019209kinase activator activity ----
         
    VAC14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for VAC14:
     Decreased Wnt reporter activit  Increased HPV18 LCR reporter a 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vac14):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  integument 
     mortality/aging  nervous system  pigmentation 

    VAC14 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAC14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VAC14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VAC14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VAC14

    miRNA
    Products:
        
    miRTarBase miRNAs that target VAC14:
    hsa-mir-200b-3p (MIRT024128), hsa-mir-429 (MIRT016639), hsa-mir-30c-2-3p (MIRT038701), hsa-mir-200c-3p (MIRT021072), hsa-mir-200a-3p (MIRT020349), hsa-mir-423-5p (MIRT038068), hsa-mir-589-5p (MIRT037789), hsa-mir-141-3p (MIRT021651)

    Block miRNA regulation of human, mouse, rat VAC14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate VAC14:
    hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidVAC14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VAC14
    Predesigned siRNA for gene silencing in human, mouse, rat VAC14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VAC14

    Clone
    Products:
         
    OriGene clones in human, mouse for VAC14 (see all 7)
    OriGene ORF clones in mouse, rat for VAC14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VAC14 (NM_018052)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAC14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAC14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VAC14
    Browse ESI BIO Cell Lines and PureStem Progenitors for VAC14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAC14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    VAC14_HUMAN, Q08AM6: Endosome membrane. Microsome membrane (By similarity). Note=Mainly associated with membranes
    of the late endocytic pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus4
    cytosol3
    endoplasmic reticulum3
    lysosome2
    vacuole2
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005783endoplasmic reticulum IEA--
    GO:0010008endosome membrane IDA17556371
    GO:0031901early endosome membrane TAS--
    GO:0031902late endosome membrane TAS--

    VAC14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for VAC14 About    
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the Golgi membrane0.00
    Synthesis of PIPs at the late endosome membrane0.00
    Synthesis of PIPs at the early endosome membrane0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64
    4Viral carcinogenesis
    Viral carcinogenesis
    5HTLV-I infection
    HTLV-I infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for VAC14
        Synthesis of PIPs at the late endosome membrane
    Synthesis of PIPs at the early endosome membrane
    Synthesis of PIPs at the Golgi membrane


    2 Kegg Pathways  (Kegg details for VAC14):
        HTLV-I infection
    Viral carcinogenesis


    VAC14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VAC14
    Interactions:

        GeneGlobe Interaction Network for VAC14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VAC14 (Q08AM61, 2, 3 ENSP000002617764) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOS1P294751, 2, 3, ENSP000003207584EBI-2107455,EBI-7164065 MINT-3999924 MINT-3999953 MINT-3999982 MINT-3999902 MINT-3999876 I2D: score=3 STRING: ENSP00000320758
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    FIG4Q925622, 3, ENSP000002301244MINT-7277770 I2D: score=6 STRING: ENSP00000230124
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0007165signal transduction NAS8611628
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    VAC14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VAC14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VAC14 gene: 
    NM_018052.3  

    Unigene Cluster for VAC14:

    Vac14 homolog (S. cerevisiae)
    Hs.445061  [show with all ESTs]
    Unigene Representative Sequence: AK128439
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567648 ENST00000568886(uc002ezl.3) ENST00000261776(uc002ezm.3 uc010cfw.3 uc002ezn.3)
    ENST00000571759(uc002ezo.1) ENST00000568548 ENST00000536184 ENST00000564512
    ENST00000566416 ENST00000564685(uc010cfx.1) ENST00000561879 ENST00000563662
    ENST00000566655
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VAC14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate VAC14:
    hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidVAC14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VAC14
    Predesigned siRNA for gene silencing in human, mouse, rat VAC14
    Clone
    Products:
         
    OriGene clones in human, mouse for VAC14 (see all 7)
    OriGene ORF clones in mouse, rat for VAC14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VAC14 (NM_018052)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VAC14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAC14
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for VAC14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAC14
      QuantiTect SYBR Green Assays in human, mouse, rat VAC14
      QuantiFast Probe-based Assays in human, mouse, rat VAC14

    Additional mRNA sequence: 

    AK001167.1 AK025479.1 AK056433.1 AK090627.1 AK128439.1 AK297564.1 AK307766.1 AK310466.1 
    AL137396.1 BC000536.2 BC007214.1 BC110072.1 BC110852.1 BC125108.1 BC125109.1 CR457343.1 
    U25801.1 

    16 DOTS entries:

    DT.444549  DT.100025998  DT.99987608  DT.100794472  DT.402903  DT.120699564  DT.97809091  DT.102830706 
    DT.120699558  DT.91674240  DT.120699514  DT.87046896  DT.95326400  DT.97847456  DT.99963761  DT.75112160 

    Selected AceView cDNA sequences (see all 258):

    AK025479 BQ014101 BM472596 BU846407 AA813461 BM904117 CA307115 BQ010258 
    BQ677264 AW964160 CB105697 AI364652 BQ647708 AK056433 CA441225 BQ880812 
    CA425376 BM712224 CF272267 BM706439 CA389947 BC000536 BQ682774 BC007214 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VAC14 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -     -                     
    SP4:                                                                                                                                -     -           -         
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for VAC14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VAC14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGTGTG
    VAC14 Expression
    About this image

    VAC14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VAC14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445061

    UniProtKB/Swiss-Prot: VAC14_HUMAN, Q08AM6
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for VAC14
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for VAC14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAC14
    QuantiTect SYBR Green Assays in human, mouse, rat VAC14
    QuantiFast Probe-based Assays in human, mouse, rat VAC14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAC14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VAC14 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vac141 , 5 Vac14 homolog (S. cerevisiae)1, 5 89.5(n)1
    94.24(a)1
      8 (57.59 cM)5
    2347291  NM_146216.21  NP_666328.21 
     1106186385 
    chicken
    (Gallus gallus)
    Aves VAC141 Vac14 homolog (S. cerevisiae) 81.81(n)
    85.49(a)
      415678  NM_001030564.1  NP_001025735.1 
    lizard
    (Anolis carolinensis)
    Reptilia VAC146
    Vac14 homolog (S. cerevisiae)
    85(a)
    1 ↔ 1
    GL343539.1(165078-227497)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vac141 Vac14 homolog 73.28(n)
    81.97(a)
      100216224  NM_001142192.1  NP_001135664.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb68e052 Transcribed sequence with moderate similarity to protein more 79.37(n)    BQ480727.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56081 CG5608 55.84(n)
    51.66(a)
      41543  NM_141951.1  NP_650208.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K04G2.61 K04G2.6 47.71(n)
    41.79(a)
      172589  NM_059814.3  NP_492215.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VAC14(YLR386W)4
    VAC141
    Protein involved in regulated synthesis of PtdIns(3,5)P(2), more4
    VAC141
    47.26(n)1
    40.85(a)1
      12(893628-896270)4
    8511021, 4  NP_013490.31  NP_013490.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G016901 AT2G01690 52.07(n)
    47.72(a)
      814698  NM_201666.1  NP_973395.1 
    rice
    (Oryza sativa)
    Liliopsida Os.116862 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.9(n)    AK068416.1 


    ENSEMBL Gene Tree for VAC14 (if available)
    TreeFam Gene Tree for VAC14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for VAC14 gene
    1 SIMAP similar gene for VAC14 using alignment to 6 protein entries:     VAC14_HUMAN (see all proteins):
    DKFZp434J032

    VAC14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VAC14
    PGOHUM00000247753


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VAC14 (see all 2028)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118641861,2
    C,F,A,H--70722103(+) GGCCTG/CTGGGC 1 -- int17Minor allele frequency- C:0.22NS NA CSA WA 330
    rs1479520231,2
    C--70722134(+) CTCTT-/CCGTCA
    TGGCGGGC
    CCCAG
    1 -- int10--------
    rs1490795471,2
    --70722291(+) GTTTAC/TGAGTG 1 -- int10--------
    rs1431494291,2
    --70722362(+) ACAGGA/GTCTGG 1 -- int10--------
    rs1512199931,2
    --70722541(+) AATGCC/TGGTCT 1 -- int10--------
    rs284832991,2
    C,F--70722542(+) ATGCCG/AGTCTC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs49854161,2
    C,F,A,H--70722940(+) CCTTCA/CAGTTT 1 -- int127Minor allele frequency- C:0.38NS EA NA CSA WA 2770
    rs1889090111,2
    --70722979(+) GAAGGC/GGGGTG 1 -- int10--------
    rs735750391,2
    C,F--70722988(+) TGCAGG/ACACTG 1 -- int13Minor allele frequency- A:0.16WA 122
    rs1817158601,2
    --70723050(+) CCTAGC/TGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for VAC14 (70721342 - 70835064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VAC14 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517391CNV Loss19592680
    dgv2904n71CNV Loss21882294
    dgv2908n71CNV Loss21882294
    dgv2906n71CNV Loss21882294
    dgv2905n71CNV Loss21882294
    nsv906885CNV Loss21882294
    nsv906888CNV Loss21882294
    dgv2907n71CNV Loss21882294
    nsv471094CNV Loss18288195
    dgv897e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VAC14
    DNA2.0 Custom Variant and Variant Library Synthesis for VAC14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604632    OMIM disorders: --

    7 diseases for VAC14:    
    About MalaCards
    communicating hydrocephalus    t-cell leukemia    hydrocephalus    leukemia
    hepatocellular carcinoma    malaria    neuronitis


    VAC14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VAC14
    Human Genome Epidemiology (HuGE) Navigator: VAC14 (1 document)

    Export disorders for VAC14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VAC14 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with VAC14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. (PubMed id 15542851)1, 2, 3, 9 Sbrissa D.... Shisheva A. (Mol. Cell. Biol. 2004)
    2. Core protein machinery for mammalian phosphatidylinositol 3,5- bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. (PubMed id 17556371)1, 2, 9 Sbrissa D....Shisheva A. (J. Biol. Chem. 2007)
    3. Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif. (PubMed id 17161399)1, 2, 9 Lemaire J.F. and McPherson P.S. (FEBS Lett. 2006)
    4. Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein. (PubMed id 8611628)1, 2, 9 Mireskandari A....Brady J.N. (Biochim. Biophys. Acta 1996)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. (PubMed id 18950639)1, 2 Sbrissa D.... Shisheva A. (J. Mol. Biol. 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. (PubMed id 12719380)1, 3 Davy B.E. and Robinson M.L. (Hum. Mol. Genet. 2003)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55697 HGNC: 25507 AceView: FLJ10305 Ensembl:ENSG00000103043 euGenes: HUgn55697
    ECgene: VAC14 Kegg: 55697 H-InvDB: VAC14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VAC14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VAC14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VAC14 gene:
    Search GeneIP for patents involving VAC14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VAC14  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for VAC14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VAC14  
     OriGene qSTAR qPCR primer pairs in human, mouse for VAC14   OriGene Purified Protein for VAC14  
     OriGene ORF clones in mouse, rat for VAC14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VAC14   OriGene Custom Protein Services for VAC14  

     
     
     Block miRNA regulation of human, mouse, rat VAC14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VAC14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VAC14 Predesigned siRNA for gene silencing in human, mouse, rat VAC14
     QuantiFast Probe-based Assays in human, mouse, rat VAC14 QuantiTect SYBR Green Assays in human, mouse, rat VAC14
     Custom PCR Arrays for VAC14 Search Chromatin IP Primers for VAC14
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VAC14  GeneGlobe Interaction Network for VAC14
     Regulatory tfbs in VAC14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for VAC14 GenScript cDNA clones with any tag delivered in your preferred vector for VAC14
     GenScript Custom Assay Services for VAC14 GenScript Custom overexpressing Cell Line Services for VAC14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for VAC14
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VAC14 antibodies
     VAC14 proteins
     VAC14 lysates
     Antibodies for VAC14
     See all of Abcam's Antibodies, Kits and Proteins for VAC14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for VAC14
     Antibodies for VAC14
     ELISAs for VAC14
     CLIAs for VAC14



     Browse ESI BIO Cell Lines and PureStem Progenitors for VAC14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VAC14
     SwitchGear 3'UTR luciferase reporter plasmids for VAC14
     SwitchGear Promoter luciferase reporter plasmids for VAC14
     Search ThermoFisher Antibodies for VAC14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VAC14
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VAC14
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VAC14
     LSBio Antibodies in human, mouse, rat for VAC14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VAC14 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4