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Aliases for UBC Gene

Aliases for UBC Gene

  • Ubiquitin C 2 3 5
  • Polyubiquitin-C 2 3
  • HMG20 3

External Ids for UBC Gene

Previous GeneCards Identifiers for UBC Gene

  • GC12M124151
  • GC12M125142
  • GC12M123749
  • GC12M123921
  • GC12M125396
  • GC12M122360

Summaries for UBC Gene

Entrez Gene Summary for UBC Gene

  • This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBC Gene

UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Apocrine Adenoma and Congenital Granular Cell Tumor. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Ovarian tumor domain proteases. GO annotations related to this gene include poly(A) RNA binding and protease binding. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot for UBC Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Wiki entry for UBC Gene

Additional gene information for UBC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBC Gene

Genomics for UBC Gene

Regulatory Elements for UBC Gene

Enhancers for UBC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H124937 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -22.2 -22150 4 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A MEF2D DHX37 ENSG00000270130 ENSG00000269938 NCOR2 ENSG00000270061 ENSG00000269997 UBC BRI3BP RPL22P19 TRD-GTC2-10
GH12H124861 1.6 FANTOM5 ENCODE dbSUPER 11 +54.2 54221 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 UBC RFLNA LOC105370050 GC12P124823
GH12H124850 1.5 Ensembl ENCODE dbSUPER 11 +63.4 63385 6 FOXA2 MLX ARID4B DMAP1 YY1 FOS SP5 ZHX2 NFYC REST SCARB1 UBC RFLNA LOC105370050 GC12P124823
GH12H124913 2.2 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -1.8 -1815 12 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC NCOR2 DHX37 ENSG00000269938 ENSG00000270130 ENSG00000269997 ENSG00000270061 DNAH10OS LOC100131779 ENSG00000256814 SCARB1
GH12H124452 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +462.0 462014 6 HDGF PKNOX1 ZNF121 GLIS2 ZNF143 FOS ATF7 RUNX3 JUNB SMARCB1 UBC ZNF664 NCOR2 LOC105370047 ENSG00000255965
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBC on UCSC Golden Path with GeneCards custom track

Promoters for UBC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000270639 -232 801 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 NR2C1

Genomic Location for UBC Gene

Chromosome:
12
Start:
124,911,604 bp from pter
End:
124,917,368 bp from pter
Size:
5,765 bases
Orientation:
Minus strand

Genomic View for UBC Gene

Genes around UBC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBC Gene

Proteins for UBC Gene

  • Protein details for UBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG48-UBC_HUMAN
    Recommended name:
    Polyubiquitin-C
    Protein Accession:
    P0CG48
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for UBC Gene

    Size:
    685 amino acids
    Molecular mass:
    77039 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

    Three dimensional structures from OCA and Proteopedia for UBC Gene

neXtProt entry for UBC Gene

Post-translational modifications for UBC Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at Lys6, posLast=1111, Lys27, posLast=2929, posLast=3333, posLast=4848, and posLast=6363
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBC Gene

Domains & Families for UBC Gene

Gene Families for UBC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBC Gene

Graphical View of Domain Structure for InterPro Entry

P0CG48

UniProtKB/Swiss-Prot:

UBC_HUMAN :
  • Belongs to the ubiquitin family.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with UBC: view

Function for UBC Gene

Molecular function for UBC Gene

GENATLAS Biochemistry:
poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit
UniProtKB/Swiss-Prot Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Phenotypes From GWAS Catalog for UBC Gene

Gene Ontology (GO) - Molecular Function for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21185309
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 8570649
genes like me logo Genes that share ontologies with UBC: view
genes like me logo Genes that share phenotypes with UBC: view

Animal Models for UBC Gene

MGI Knock Outs for UBC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBC
  • Applied Biological Materials Clones for UBC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBC Gene

Localization for UBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBC gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
endosome 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA,IEA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with UBC: view

Pathways & Interactions for UBC Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Activated TLR4 signalling
4 HIV Life Cycle
.45
5 Signaling by NOTCH1
genes like me logo Genes that share pathways with UBC: view

Gene Ontology (GO) - Biological Process for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination TAS --
genes like me logo Genes that share ontologies with UBC: view

No data available for SIGNOR curated interactions for UBC Gene

Drugs & Compounds for UBC Gene

(3) Drugs for UBC Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Formylmethionine Experimental Pharma Target 0

(1) Additional Compounds for UBC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBC: view

Transcripts for UBC Gene

Unigene Clusters for UBC Gene

Ubiquitin C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBC
  • Applied Biological Materials Clones for UBC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3:

Relevant External Links for UBC Gene

GeneLoc Exon Structure for
UBC
ECgene alternative splicing isoforms for
UBC

Expression for UBC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBC Gene

mRNA differential expression in normal tissues according to GTEx for UBC Gene

This gene is overexpressed in Muscle - Skeletal (x4.6) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for UBC Gene

This gene is overexpressed in Heart (29.0), Brain (21.2), and Skin (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBC Gene



Protein tissue co-expression partners for UBC Gene

NURSA nuclear receptor signaling pathways regulating expression of UBC Gene:

UBC

SOURCE GeneReport for Unigene cluster for UBC Gene:

Hs.520348

Evidence on tissue expression from TISSUES for UBC Gene

  • Kidney(5)
  • Liver(5)
  • Lung(5)
  • Nervous system(5)
  • Blood(4.9)
  • Intestine(4.9)
  • Skin(4.9)
  • Spleen(4.9)
  • Heart(4.8)
  • Pancreas(4.6)
  • Stomach(4.6)
  • Eye(4.3)
  • Muscle(4.3)
  • Thyroid gland(3.9)
  • Bone(3.5)
  • Bone marrow(3.2)
  • Adrenal gland(3.1)
  • Lymph node(3)
  • Gall bladder(2.8)
genes like me logo Genes that share expression patterns with UBC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBC Gene

Orthologs for UBC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBC Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UBB 34
  • 99 (a)
ManyToMany
UBC 33
  • 94.01 (n)
cow
(Bos Taurus)
Mammalia UBC 33 34
  • 90.75 (n)
mouse
(Mus musculus)
Mammalia Ubc 33 16 34
  • 89.83 (n)
dog
(Canis familiaris)
Mammalia UBC 33
  • 89.76 (n)
rat
(Rattus norvegicus)
Mammalia Ubc 33
  • 88.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBB